Euan Robert Brown, BSc, PhD.
Affiliations: | 2012- | Institute of Biological Chemistry, Biophysics and Bioengineering | Heriot-Watt University, Edinburgh, Scotland, UK |
Area:
Ion channels, Invertebrates, Vertebrates, Neurons, Glia,Website:
https://pureapps2.hw.ac.uk/portal/en/persons/euan-r-brown%2818f02f0b-5072-4813-b9ce-a9c1cddc3119%29.htmlGoogle:
"http://scholar.google.co.uk/citations?user=zEk5V20AAAAJ&hl=en"Bio:
Dr Euan Brown works on the biophysics of membrane ion channels. These tiny proteins are nanoscale molecular machines that permit membrane based signals such as secretion, neurotransmission and electrical conduction to occur. His projects have involved the study of ion channels in glial- neuronal interactions, EC coupling and neural network function. He has worked at the Marine Biological Association UK, Leicester University, UK , and most recently at the Stazione Zoologica Anton Dohrn, Naples, Italy.
During this time he has contributed to understanding the evolution of ion channels not just at the molecular, but also at the system level. He has developed both single cell and system techniques to study their real-time activity using voltage clamp and single channel measurement systems. Now he is now developing approaches/technologies to use them both as medium throughput biosensors in drug screening/toxicology and as real-time systems to study cellular function.
Children
Sign in to add trainee| Saverio Gentile | grad student | Stazione Zoologica | |
| Mohammed Mohammed Idris | grad student | Stazione Zoologica | |
| Marina Langella | grad student | Stazione Zoologica | |
| Pedro A. Lima | grad student | 1998-2002 | University of Lisbon, Portugal |
| Matt Euston | grad student | 2014-2018 | Heriot-Watt University |
| Kyriakos Michael | grad student | 2016-2020 | Heriot-Watt University |
| Mario Alvarez Martinez | grad student | 2019-2022 | Heriot-Watt University |
| Candida Rogers | post-doc | Marine Biological Association of the UK | |
| Irina Vinogradova | post-doc | Marine Biological Association of the UK | |
| Stefania Piscopo | research scientist | Stazione Zoologica |
Publications
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| Berghoff SA, Spieth L, Sun T, et al. (2021) Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice. Cell Reports. 37: 109889 |
| Bijland S, Thomson G, Euston M, et al. (2019) An in vitro model for studying CNS white matter: functional properties and experimental approaches. F1000research. 8: 117 |
| Piscopo S, Brown ER. (2018) Zinc Oxide Nanoparticles and Voltage-Gated Human K11.1 Potassium Channels Interact through a Novel Mechanism. Small (Weinheim An Der Bergstrasse, Germany) |
| Kriplani N, Hermida MA, Brown ER, et al. (2015) Class I PI 3-kinases: Function and evolution. Advances in Biological Regulation. 59: 53-64 |
| Johnston H, Brown DM, Kanase N, et al. (2015) Mechanism of neutrophil activation and toxicity elicited by engineered nanomaterials. Toxicology in Vitro : An International Journal Published in Association With Bibra. 29: 1172-84 |
| Kriplani N, Hermida MA, Brown ER, et al. (2015) Class I PI 3-kinases: Function and evolution Advances in Biological Regulation |
| Kavanagh DM, Smyth AM, Martin KJ, et al. (2014) A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion. Nature Communications. 5: 5774 |
| Hiersemenzel K, Brown ER, Duncan RR. (2013) Imaging large cohorts of single ion channels and their activity. Frontiers in Endocrinology. 4: 114 |
| Idris MM, Thorndyke MC, Brown ER. (2013) Evidence for dynamic and multiple roles for huntingtin in Ciona intestinalis. Invertebrate Neuroscience : In. 13: 151-65 |
| Brown ER, Piscopo S. (2013) Synaptic plasticity in cephalopods; more than just learning and memory? Invertebrate Neuroscience : In. 13: 35-44 |