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Charalampos (Babis) Rallis, PhD

Affiliations: 
2020- School of Life Sciences University of Essex (United Kingdom) 
Area:
Cellular ageing, nutrient signalling
Website:
www.rallislab.org
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"Charalampos Rallis"
Bio:

The Rallis Lab uses Systems Biology approaches in fission yeast and human tissue culture systems to investigate the molecular basis of cellular fitness, cancer and ageing with a focus on the nutrient-responsive signalling pathway Target of Rapamycin (TOR). The aim is to elucidate the molecular mechanisms and principles behind senescence and lifespan and apply this knowledge for the amelioration of age-related diseases.

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Jurg Bahler post-doc

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Publications

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Gal C, Cochrane GA, Morgan BA, et al. (2023) The longevity and reversibility of quiescence in are dependent upon the HIRA histone chaperone. Cell Cycle (Georgetown, Tex.). 1-16
Islam RA, Rallis C. (2023) Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging. Epigenomes. 7
Legon L, Rallis C. (2021) Genome-wide screens in yeast models towards understanding chronological lifespan regulation. Briefings in Functional Genomics
Rallis C, Mülleder M, Smith G, et al. (2020) Amino acids whose intracellular levels change most during aging alter chronological lifespan of fission yeast. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences
Rodríguez-López M, Gonzalez S, Hillson O, et al. (2020) The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1. Cell Reports. 30: 3240-3249.e4
Pai CC, Hsu KF, Durley SC, et al. (2019) An essential role for dNTP homeostasis following CDK-induced replication stress. Journal of Cell Science
Ellis DA, Mustonen V, Rodríguez-López M, et al. (2018) Uncovering Natural Longevity Alleles from Intercrossed Pools of Aging Fission Yeast Cells. Genetics
Atkinson S, Marguerat S, Bitton D, et al. (2018) Long non-coding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease and RNAi in fission yeast. Rna (New York, N.Y.)
Hoyos-Manchado R, Reyes-Martín F, Rallis C, et al. (2017) RNA metabolism is the primary target of formamide in vivo. Scientific Reports. 7: 15895
Rallis C, Townsend S, Bähler J. (2017) Corrigendum: Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Scientific Reports. 7: 46857
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