Joshua J. Higgin, Ph.D.
Affiliations: | 2004 | University of Wisconsin, Madison, Madison, WI |
Area:
Chemical biology, protein design and engineering, enzymology, biofuelsGoogle:
"Joshua Higgin"Parents
Sign in to add mentor| Ronald T. Raines | grad student | 2004 | UW Madison | |
| (Small -molecule enzyme inhibitors utilizing active-site metal chelation: Prolyl 4 -hydroxylase and microbial ribonucleases) | ||||
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Publications
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| Vasta JD, Higgin JJ, Kersteen EA, et al. (2013) Bioavailable affinity label for collagen prolyl 4-hydroxylase. Bioorganic & Medicinal Chemistry. 21: 3597-601 |
| Smith BD, Higgin JJ, Raines RT. (2011) Site-specific folate conjugation to a cytotoxic protein. Bioorganic & Medicinal Chemistry Letters. 21: 5029-32 |
| Kersteen EA, Higgin JJ, Raines RT. (2004) Production of human prolyl 4-hydroxylase in Escherichia coli. Protein Expression and Purification. 38: 279-91 |
| Makarov AA, Yakovlev GI, Mitkevich VA, et al. (2004) Zinc(II)-mediated inhibition of ribonuclease Sa by an N-hydroxyurea nucleotide and its basis. Biochemical and Biophysical Research Communications. 319: 152-6 |
| Wright G, Higgin JJ, Raines RT, et al. (2003) Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes. The Journal of Biological Chemistry. 278: 20235-9 |
| Higgin JJ, Yakovlev GI, Mitkevich VA, et al. (2003) Zinc(II)-mediated inhibition of a ribonuclease by an N-hydroxyurea nucleotide. Bioorganic & Medicinal Chemistry Letters. 13: 409-12 |
| Friedman L, Higgin JJ, Moulder G, et al. (2000) Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 97: 4736-41 |