Brian R. Keppler, Ph.D.

Michael B. Jarstfer	grad student	2006	UNC Chapel Hill
(Human telomerase holoenzyme assemblage as an anticancer drug target.)

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Soares J, Keppler BR, Wang X, et al. (2011) ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide. Bioorganic & Medicinal Chemistry Letters. 21: 7474-8
Fu YT, Keppler BR, Soares J, et al. (2009) BRACO19 analog dimers with improved inhibition of telomerase and hPot 1. Bioorganic & Medicinal Chemistry. 17: 2030-7
FouchÃ© N, Moon IK, Keppler BR, et al. (2006) Electron microscopic visualization of telomerase from Euplotes aediculatus bound to a model telomere DNA. Biochemistry. 45: 9624-31
Keppler BR, Grady AT, Jarstfer MB. (2006) The biochemical role of the heat shock protein 90 chaperone complex in establishing human telomerase activity. The Journal of Biological Chemistry. 281: 19840-8
Keppler BR, Jarstfer MB. (2006) A high-throughput assay for a human telomerase protein-human telomerase RNA interaction. Analytical Biochemistry. 353: 75-82
Dominick PK, Keppler BR, Legassie JD, et al. (2004) Nucleic acid-binding ligands identify new mechanisms to inhibit telomerase. Bioorganic & Medicinal Chemistry Letters. 14: 3467-71
Keppler BR, Jarstfer MB. (2004) Inhibition of telomerase activity by preventing proper assemblage. Biochemistry. 43: 334-43