Dorothee Kern, Ph.D.
Affiliations: | Biochemistry | Brandeis University, Waltham, MA, United States |
Area:
enzymology, NMRGoogle:
"Dorothee Kern"Cross-listing: Chemistry Tree
Parents
Sign in to add mentorGunter S. Fischer | grad student | 1989-1994 | Brandeis (Chemistry Tree) |
David E. Wemmer | post-doc | 1995-1998 | UC Berkeley (Chemistry Tree) |
Children
Sign in to add traineeDaryl A. Bosco | grad student | 2004 | Brandeis (Chemistry Tree) |
Alexandra K. Gardino | grad student | 2005 | Brandeis |
Vu T. Thai | grad student | 2007 | Brandeis |
Wladimir Labeikovsky | grad student | 2008 | Brandeis |
Janice Velos | grad student | 2009 | Brandeis |
S. J. Kerns | grad student | 2010 | Brandeis |
Dimitar V. Pachov | grad student | 2010 | Brandeis |
Aleksandr Milshteyn | grad student | 2011 | Brandeis |
Katherine Henzler-Wildman | post-doc | 2003-2008 | Brandeis (Chemistry Tree) |
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Publications
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Stiller JB, Otten R, Häussinger D, et al. (2022) Structure determination of high-energy states in a dynamic protein ensemble. Nature. 603: 528-535 |
Otten R, Pádua RAP, Bunzel HA, et al. (2020) How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science (New York, N.Y.) |
Hoemberger M, Pitsawong W, Kern D. (2020) Cumulative mechanism of several major imatinib-resistant mutations in Abl kinase. Proceedings of the National Academy of Sciences of the United States of America |
Hadzipasic A, Wilson C, Nguyen V, et al. (2020) Ancient origins of allosteric activation in a Ser-Thr kinase. Science (New York, N.Y.). 367: 912-917 |
Stiller JB, Kerns SJ, Hoemberger M, et al. (2019) Probing the Transition State in Enzyme Catalysis by High-Pressure NMR Dynamics. Nature Catalysis. 2: 726-734 |
Zorba A, Nguyen V, Koide A, et al. (2019) Allosteric modulation of a human protein kinase with monobodies. Proceedings of the National Academy of Sciences of the United States of America |
Pádua RAP, Sun Y, Marko I, et al. (2018) Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nature Communications. 9: 4507 |
Pitsawong W, Buosi V, Otten R, et al. (2018) Dynamics of human protein kinase Aurora A linked to drug selectivity. Elife. 7 |
Otten R, Liu L, Kenner LR, et al. (2018) Rescue of conformational dynamics in enzyme catalysis by directed evolution. Nature Communications. 9: 1314 |
Pitsawong W, Buosi V, Otten R, et al. (2018) Author response: Dynamics of human protein kinase Aurora A linked to drug selectivity Elife |