| Year |
Citation |
Score |
| 2023 |
Zhou Y, Mowlazadeh Haghighi S, Sawyer JR, Hruby VJ, Cai M. Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH Lead to Potent and Selective Agonists at hMC1R and hMC4R. Journal of Medicinal Chemistry. 66: 6715-6724. PMID 37133411 DOI: 10.1021/acs.jmedchem.2c01794 |
0.631 |
|
| 2022 |
Tomassi S, Dimmito MP, Cai M, D'Aniello A, Del Bene A, Messere A, Liu Z, Zhu T, Hruby VJ, Stefanucci A, Cosconati S, Mollica A, Di Maro S. CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists. Journal of Medicinal Chemistry. PMID 35188390 DOI: 10.1021/acs.jmedchem.1c01848 |
0.585 |
|
| 2021 |
Zhou Y, Chawla MK, Rios-Monterrosa JL, Wang L, Zempare MA, Hruby VJ, Barnes CA, Cai M. Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions. Molecules (Basel, Switzerland). 26. PMID 34684847 DOI: 10.3390/molecules26206266 |
0.369 |
|
| 2021 |
Kondrashov M, Svensson SPS, Ström P, Westermark A, Jacobson-Ingemyr H, Takano A, Tari L, Tóth M, Cai M, Hruby VJ, Schou M. Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma. Bioconjugate Chemistry. PMID 33576604 DOI: 10.1021/acs.bioconjchem.0c00671 |
0.379 |
|
| 2020 |
Zhou Y, Mowlazadeh Haghighi S, Liu Z, Wang L, Hruby VJ, Cai M. Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor. Acs Pharmacology & Translational Science. 3: 921-930. PMID 33073191 DOI: 10.1021/acsptsci.0c00072 |
0.407 |
|
| 2020 |
Kadiri JJ, Thapa K, Kaipio K, Cai M, Hruby VJ, Rinne P. Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice. European Journal of Pharmacology. 173186. PMID 32416182 DOI: 10.1016/J.Ejphar.2020.173186 |
0.482 |
|
| 2019 |
Zhou Y, Banday AH, Hruby VJ, Cai M. Development of -Acetylated Dipalmitoyl--Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists. Molecules (Basel, Switzerland). 24. PMID 31569697 DOI: 10.3390/Molecules24193512 |
0.356 |
|
| 2018 |
Zhou Y, Mowlazadeh Haghighi S, Zoi I, Sawyer JR, Hruby VJ, Cai M. Correction to Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation. Journal of Medicinal Chemistry. PMID 30252463 DOI: 10.1021/Acs.Jmedchem.8B01423 |
0.417 |
|
| 2018 |
Eerola K, Virtanen S, Vähätalo L, Ailanen L, Cai M, Hruby V, Savontaus M, Savontaus E. Hypothalamic γ-melanocyte stimulating hormone gene delivery reduces fat mass in male mice. The Journal of Endocrinology. PMID 30006340 DOI: 10.1530/Joe-18-0009 |
0.331 |
|
| 2018 |
Mowlazadeh Haghighi S, Zhou Y, Dai J, Sawyer JR, Hruby VJ, Cai M. Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH, leads to hMC1R selectivity and pigmentation. European Journal of Medicinal Chemistry. 151: 815-823. PMID 29679901 DOI: 10.1016/J.Ejmech.2018.04.021 |
0.529 |
|
| 2018 |
Merlino F, Zhou Y, Cai M, Carotenuto A, Yousif AM, Brancaccio D, Di Maro S, Zappavigna S, Limatola A, Novellino E, Grieco P, Hruby VJ. Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors. Journal of Medicinal Chemistry. PMID 29660981 DOI: 10.1021/Acs.Jmedchem.8B00488 |
0.579 |
|
| 2018 |
Durek T, Cromm PM, White AM, Schroeder CI, Kaas Q, Weidmann J, Ahmad Fuaad A, Cheneval O, Harvey PJ, Daly NL, Zhou Y, Dellsén A, Österlund T, Larsson N, Knerr L, ... Cai M, et al. Development of novel melanocortin receptor agonists based on the cyclic peptide framework of sunflower trypsin inhibitor-1. Journal of Medicinal Chemistry. PMID 29605997 DOI: 10.1021/Acs.Jmedchem.8B00170 |
0.53 |
|
| 2017 |
Zhou Y, Mowlazadeh Haghighi S, Zoi I, Sawyer JR, Hruby VJ, Cai M. Design of MC1R selective γ-MSH analogues with canonical amino acids leads to potency and pigmentation. Journal of Medicinal Chemistry. PMID 29094944 DOI: 10.1021/Acs.Jmedchem.7B01295 |
0.589 |
|
| 2017 |
Cai M, Marelli UK, Mertz B, Beck JG, Opperer F, Rechenmacher F, Kessler H, Hruby VJ. Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists. Biochemistry. PMID 28715181 DOI: 10.1021/Acs.Biochem.7B00407 |
0.638 |
|
| 2017 |
Zhou Y, Cai M. Novel approaches to the design of bioavailable melanotropins. Expert Opinion On Drug Discovery. 1-8. PMID 28699792 DOI: 10.1080/17460441.2017.1351940 |
0.332 |
|
| 2017 |
Rinne P, Rami M, Nuutinen SL, Santovito D, van der Vorst EPC, Guillamat-Prats R, Lyytikäinen LP, Raitoharju E, Oksala N, Ring L, Cai M, Hruby VJ, Lehtimäki TJ, Weber C, Steffens S. Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages. Circulation. PMID 28450348 DOI: 10.1161/Circulationaha.116.025889 |
0.345 |
|
| 2016 |
Cai M, Hruby VJ. Design of Cyclized Selective Melanotropins. Biopolymers. PMID 27561155 DOI: 10.1002/Bip.22976 |
0.543 |
|
| 2016 |
Cai M, Hruby VJ. The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases. Current Protein & Peptide Science. PMID 26916163 DOI: 10.2174/1389203717666160226145330 |
0.659 |
|
| 2015 |
Carotenuto A, Merlino F, Cai M, Brancaccio D, Yousif AM, Novellino E, Hruby VJ, Grieco P. Discovery of Novel Potent and Selective Agonists at the Melanocortin‑3 Receptor. Journal of Medicinal Chemistry. PMID 26599352 DOI: 10.1021/Acs.Jmedchem.5B01285 |
0.644 |
|
| 2015 |
Wei JH, Haddad A, Wu KJ, Zhao HW, Kapur P, Zhang ZL, Zhao LY, Chen ZH, Zhou YY, Zhou JC, Wang B, Yu YH, Cai MY, Xie D, Liao B, et al. A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma. Nature Communications. 6: 8699. PMID 26515236 DOI: 10.1038/ncomms9699 |
0.351 |
|
| 2015 |
Shukla C, Koch LG, Britton SL, Cai M, Hruby VJ, Bednarek M, Novak CM. Contribution of regional brain melanocortin receptor subtypes to elevated activity energy expenditure in lean, active rats. Neuroscience. PMID 26404873 DOI: 10.1016/J.Neuroscience.2015.09.035 |
0.461 |
|
| 2015 |
Cai M, Marelli UK, Bao J, Beck JG, Opperer F, Rechenmacher F, McLeod KR, Zingsheim MR, Doedens L, Kessler H, Hruby VJ. Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors. Journal of Medicinal Chemistry. 58: 6359-67. PMID 26218460 DOI: 10.1021/Acs.Jmedchem.5B00102 |
0.619 |
|
| 2015 |
Van der Poorten O, Fehér K, Buysse K, Feytens D, Zoi I, Schwartz SD, Martins JC, Tourwé D, Cai M, Hruby VJ, Ballet S. Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist. Acs Medicinal Chemistry Letters. 6: 192-7. PMID 25699148 DOI: 10.1021/Ml500436S |
0.582 |
|
| 2015 |
Cai M, Marelli UK, Bao J, Beck JG, Opperer F, Rechenmacher F, McLeod KR, Zingsheim MR, Doedens L, Kessler H, Hruby VJ. Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors Journal of Medicinal Chemistry. 58: 6359-6367. DOI: 10.1021/acs.jmedchem.5b00102 |
0.559 |
|
| 2013 |
Hruby VJ, Cai M. Design of peptide and peptidomimetic ligands with novel pharmacological activity profiles. Annual Review of Pharmacology and Toxicology. 53: 557-80. PMID 23294313 DOI: 10.1146/Annurev-Pharmtox-010510-100456 |
0.512 |
|
| 2013 |
Cai M, Stankova M, Muthu D, Mayorov A, Yang Z, Trivedi D, Cabello C, Hruby VJ. An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells. Biochemistry. 52: 752-64. PMID 23276279 DOI: 10.1021/Bi300723F |
0.823 |
|
| 2013 |
Rinne P, Nordlund W, Heinonen I, Penttinen AM, Saraste A, Ruohonen ST, Mäkelä S, Vähätalo L, Kaipio K, Cai M, Hruby VJ, Ruohonen S, Savontaus E. α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction. Cardiovascular Research. 97: 360-8. PMID 23131503 DOI: 10.1093/Cvr/Cvs335 |
0.354 |
|
| 2011 |
Hruby VJ, Cai M, Nyberg J, Muthu D. Approaches to the rational design of selective melanocortin receptor antagonists. Expert Opinion On Drug Discovery. 6: 543-57. PMID 22646078 DOI: 10.1517/17460441.2011.565743 |
0.848 |
|
| 2011 |
Mayorov AV, Cai M, Palmer ES, Tanaka DK, Cain JP, Dedek MM, Tan B, Trivedi D, Hruby VJ. Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 21: 3099-102. PMID 21486697 DOI: 10.1016/J.Bmcl.2011.03.019 |
0.826 |
|
| 2011 |
Cai M, Liu Z, Qu H, Fan H, Zheng Z, Hruby VJ. Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma. European Journal of Pharmacology. 660: 188-93. PMID 21315067 DOI: 10.1016/J.Ejphar.2011.01.032 |
0.613 |
|
| 2011 |
Hruby VJ, Cai M, Cain J, Nyberg J, Trivedi D. Design of novel melanocortin receptor ligands: multiple receptors, complex pharmacology, the challenge. European Journal of Pharmacology. 660: 88-93. PMID 21208601 DOI: 10.1016/J.Ejphar.2010.10.109 |
0.84 |
|
| 2010 |
Mayorov AV, Cai M, Palmer ES, Liu Z, Cain JP, Vagner J, Trivedi D, Hruby VJ. Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors. Peptides. 31: 1894-905. PMID 20688117 DOI: 10.1016/J.Peptides.2010.06.026 |
0.822 |
|
| 2010 |
Doedens L, Opperer F, Cai M, Beck JG, Dedek M, Palmer E, Hruby VJ, Kessler H. Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies. Journal of the American Chemical Society. 132: 8115-28. PMID 20496895 DOI: 10.1021/Ja101428M |
0.52 |
|
| 2010 |
Juni A, Cai M, Stankova M, Waxman AR, Arout C, Klein G, Dahan A, Hruby VJ, Mogil JS, Kest B. Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor. Anesthesiology. 112: 181-8. PMID 19996949 DOI: 10.1097/Aln.0B013E3181C53849 |
0.644 |
|
| 2009 |
Yang Y, Hruby VJ, Chen M, Crasto C, Cai M, Harmon CM. Novel binding motif of ACTH analogues at the melanocortin receptors. Biochemistry. 48: 9775-84. PMID 19743876 DOI: 10.1021/Bi900634E |
0.55 |
|
| 2009 |
Cai M, Nyberg J, Hruby VJ. Melanotropins as drugs for the treatment of obesity and other feeding disorders: potential and problems. Current Topics in Medicinal Chemistry. 9: 554-63. PMID 19689365 DOI: 10.2174/156802609788897817 |
0.821 |
|
| 2009 |
Qu H, Cai M, Mayorov AV, Grieco P, Zingsheim M, Trivedi D, Hruby VJ. Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor. Journal of Medicinal Chemistry. 52: 3627-35. PMID 19473029 DOI: 10.1021/Jm801300C |
0.827 |
|
| 2009 |
Salamon Z, Fitch J, Cai M, Tumati S, Navratilova E, Tollin G. Plasmon-waveguide resonance studies of ligand binding to integral proteins in membrane fragments derived from bacterial and mammalian cells. Analytical Biochemistry. 387: 95-101. PMID 19454250 DOI: 10.1016/J.Ab.2009.01.019 |
0.411 |
|
| 2009 |
Hruby VJ, Cai M, Dedek M, Qu H, Palmer E, Mayorov A, Trivedi D, Tsaprailis G, Yang Y. Peptide and non-peptide mimetics utilize different pathways for signal transduction. Advances in Experimental Medicine and Biology. 611: 305-7. PMID 19400204 DOI: 10.1007/978-0-387-73657-0_137 |
0.791 |
|
| 2009 |
Min BJ, Mayorov AV, Cai M, Palmer E, Hruby VJ. Design and parallel synthesis of new bicyclic small molecules for targeting the melanocortin receptors. Advances in Experimental Medicine and Biology. 611: 187-8. PMID 19400153 DOI: 10.1007/978-0-387-73657-0_86 |
0.732 |
|
| 2009 |
Yang Y, Cai M, Chen M, Qu H, McPherson D, Hruby V, Harmon CM. Key amino acid residues in the melanocortin-4 receptor for nonpeptide THIQ specific binding and signaling. Regulatory Peptides. 155: 46-54. PMID 19303903 DOI: 10.1016/J.Regpep.2009.03.006 |
0.658 |
|
| 2009 |
Chen M, Cai M, McPherson D, Hruby V, Harmon CM, Yang Y. Contribution of the transmembrane domain 6 of melanocortin-4 receptor to peptide [Pro5, DNal (2')8]-gamma-MSH selectivity. Biochemical Pharmacology. 77: 114-24. PMID 18930713 DOI: 10.1016/J.Bcp.2008.09.023 |
0.601 |
|
| 2008 |
Grieco P, Cai M, Liu L, Mayorov A, Chandler K, Trivedi D, Lin G, Campiglia P, Novellino E, Hruby VJ. Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists. Journal of Medicinal Chemistry. 51: 2701-7. PMID 18412316 DOI: 10.1021/Jm701181N |
0.815 |
|
| 2008 |
Lee M, Kim A, Conwell IM, Hruby V, Mayorov A, Cai M, Wardlaw SL. Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression. Peptides. 29: 440-7. PMID 18155809 DOI: 10.1016/J.Peptides.2007.11.005 |
0.692 |
|
| 2008 |
Mayorov AV, Cai M, Palmer ES, Dedek MM, Cain JP, Van Scoy AR, Tan B, Vagner J, Trivedi D, Hruby VJ. Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor. Journal of Medicinal Chemistry. 51: 187-95. PMID 18088090 DOI: 10.1021/Jm070461W |
0.803 |
|
| 2008 |
Lee YS, Agnes RS, Cain JP, Kulkarni V, Cai M, Salibay C, Ciano K, Petrov R, Mayorov A, Vagner J, Trivedi D, Davis P, Ma SW, Lai J, Porreca F, et al. Opioid and melanocortin receptors: do they have overlapping pharmacophores? Biopolymers. 90: 433-8. PMID 17657709 DOI: 10.1002/Bip.20814 |
0.806 |
|
| 2007 |
Hruby VJ, Cai M, Cain JP, Mayorov AV, Dedek MM, Trivedi D. Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor. Current Topics in Medicinal Chemistry. 7: 1107-19. PMID 17584128 DOI: 10.2174/156802607780906645 |
0.783 |
|
| 2007 |
Chen M, Cai M, Aprahamian CJ, Georgeson KE, Hruby V, Harmon CM, Yang Y. Contribution of the conserved amino acids of the melanocortin-4 receptor in [corrected] [Nle4,D-Phe7]-alpha-melanocyte-stimulating [corrected] hormone binding and signaling. The Journal of Biological Chemistry. 282: 21712-9. PMID 17545153 DOI: 10.1074/Jbc.M702285200 |
0.473 |
|
| 2007 |
Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 28: 1191-6. PMID 17482720 DOI: 10.1016/J.Peptides.2007.02.012 |
0.765 |
|
| 2007 |
Ballet S, Mayorov AV, Cai M, Tymecka D, Chandler KB, Palmer ES, Rompaey KV, Misicka A, Tourwé D, Hruby VJ. Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold. Bioorganic & Medicinal Chemistry Letters. 17: 2492-8. PMID 17314042 DOI: 10.1016/J.Bmcl.2007.02.020 |
0.765 |
|
| 2006 |
Ying J, Gu X, Cai M, Dedek M, Vagner J, Trivedi DB, Hruby VJ. Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor. Journal of Medicinal Chemistry. 49: 6888-96. PMID 17154518 DOI: 10.1021/Jm060768F |
0.826 |
|
| 2006 |
Cai M, Varga EV, Stankova M, Mayorov A, Perry JW, Yamamura HI, Trivedi D, Hruby VJ. Cell signaling and trafficking of human melanocortin receptors in real time using two-photon fluorescence and confocal laser microscopy: differentiation of agonists and antagonists. Chemical Biology & Drug Design. 68: 183-93. PMID 17105482 DOI: 10.1111/J.1747-0285.2006.00432.X |
0.806 |
|
| 2006 |
Hruby VJ, Porreca F, Yamamura HI, Tollin G, Agnes RS, Lee YS, Cai M, Alves I, Cowell S, Varga E, Davis P, Salamon Z, Roeske W, Vanderah T, Lai J. New paradigms and tools in drug design for pain and addiction. The Aaps Journal. 8: E450-60. PMID 17025262 DOI: 10.1208/Aapsj080353 |
0.799 |
|
| 2006 |
Cain JP, Mayorov AV, Cai M, Wang H, Tan B, Chandler K, Lee Y, Petrov RR, Trivedi D, Hruby VJ. Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 16: 5462-7. PMID 16931008 DOI: 10.1016/J.Bmcl.2006.07.015 |
0.837 |
|
| 2006 |
Mayorov AV, Han SY, Cai M, Hammer MR, Trivedi D, Hruby VJ. Effects of macrocycle size and rigidity on melanocortin receptor-1 and -5 selectivity in cyclic lactam alpha-melanocyte-stimulating hormone analogs. Chemical Biology & Drug Design. 67: 329-35. PMID 16784457 DOI: 10.1111/J.1747-0285.2006.00383.X |
0.79 |
|
| 2006 |
Mayorov AV, Cai M, Chandler KB, Petrov RR, Van Scoy AR, Yu Z, Tanaka DK, Trivedi D, Hruby VJ. Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. Journal of Medicinal Chemistry. 49: 1946-52. PMID 16539382 DOI: 10.1021/Jm0510326 |
0.852 |
|
| 2006 |
Grieco P, Cai M, Mayorov AV, Trivedi D, Hruby VJ. Structure-activity studies of new melanocortin peptides containing an aromatic amino acid at the N-terminal position. Peptides. 27: 472-81. PMID 16303211 DOI: 10.1016/J.Peptides.2005.01.032 |
0.768 |
|
| 2005 |
Cai M, Mayorov AV, Ying J, Stankova M, Trivedi D, Cabello C, Hruby VJ. Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors. Peptides. 26: 1481-5. PMID 15876475 DOI: 10.1016/J.Peptides.2005.03.020 |
0.849 |
|
| 2005 |
Cai M, Mayorov AV, Cabello C, Stankova M, Trivedi D, Hruby VJ. Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues. Journal of Medicinal Chemistry. 48: 1839-48. PMID 15771429 DOI: 10.1021/Jm049579S |
0.795 |
|
| 2004 |
Cai M, Stankova M, Pond SJ, Mayorov AV, Perry JW, Yamamura HI, Trivedi D, Hruby VJ. Real time differentiation of G-protein coupled receptor (GPCR) agonist and antagonist by two photon fluorescence laser microscopy. Journal of the American Chemical Society. 126: 7160-1. PMID 15186137 DOI: 10.1021/Ja049473M |
0.826 |
|
| 2004 |
Cai M, Cai C, Mayorov AV, Xiong C, Cabello CM, Soloshonok VA, Swift JR, Trivedi D, Hruby VJ. Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity. The Journal of Peptide Research : Official Journal of the American Peptide Society. 63: 116-31. PMID 15009533 DOI: 10.1111/J.1399-3011.2003.00105.X |
0.84 |
|
| 2003 |
Balse-Srinivasan P, Grieco P, Cai M, Trivedi D, Hruby VJ. Structure-activity relationships of gamma-MSH analogues at the human melanocortin MC3, MC4, and MC5 receptors. Discovery of highly selective hMC3R, hMC4R, and hMC5R analogues. Journal of Medicinal Chemistry. 46: 4965-73. PMID 14584947 DOI: 10.1021/Jm030119T |
0.582 |
|
| 2003 |
Balse-Srinivasan P, Grieco P, Cai M, Trivedi D, Hruby VJ. Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R. Journal of Medicinal Chemistry. 46: 3728-33. PMID 12904077 DOI: 10.1021/Jm030111J |
0.564 |
|
| 2003 |
Hruby VJ, Cai M, Grieco P, Han G, Kavarana M, Trivedi D. Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors. Annals of the New York Academy of Sciences. 994: 12-20. PMID 12851293 DOI: 10.1111/J.1749-6632.2003.Tb03157.X |
0.751 |
|
| 2003 |
Wang W, Cai M, Xiong C, Zhang J, Trivedi D, Hruby VJ. Design and Synthesis of Novel χ2-Constrained Phenylalanine, Naphthylalanine, and Tryptophan Analogues and Their Use in Biologically Active Melanotropin Peptides. Cheminform. 34. DOI: 10.1016/S0040-4020(02)00588-4 |
0.723 |
|
| 2002 |
Grieco P, Lavecchia A, Cai M, Trivedi D, Weinberg D, MacNeil T, Van der Ploeg LH, Hruby VJ. Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors. Journal of Medicinal Chemistry. 45: 5287-94. PMID 12431055 DOI: 10.1021/Jm0202526 |
0.608 |
|
| 2002 |
Kavarana MJ, Trivedi D, Cai M, Ying J, Hammer M, Cabello C, Grieco P, Han G, Hruby VJ. Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors. Journal of Medicinal Chemistry. 45: 2644-50. PMID 12036373 DOI: 10.1021/Jm020021Z |
0.815 |
|
| 2002 |
Wang W, Cai M, Xiong C, Zhang J, Trivedi D, Hruby VJ. Design and synthesis of novel χ2-constrained phenylalanine, naphthylalanine, and tryptophan analogues and their use in biologically active melanotropin peptides Tetrahedron. 58: 7365-7374. DOI: 10.1016/S0040-4020(02)00588-4 |
0.703 |
|
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