| Year |
Citation |
Score |
| 2021 |
Chen WLK, Suter E, Miyazaki H, Velazquez J, Lauffenburger DA, Griffith LG, Carrier RL. Synergistic Action of Diclofenac with Endotoxin-Mediated Inflammation Exacerbates Intestinal Injury . Acs Infectious Diseases. PMID 33745271 DOI: 10.1021/acsinfecdis.0c00762 |
0.504 |
|
| 2021 |
Trapecar M, Wogram E, Svoboda D, Communal C, Omer A, Lungjangwa T, Sphabmixay P, Velazquez J, Schneider K, Wright CW, Mildrum S, Hendricks A, Levine S, Muffat J, Lee MJ, ... Lauffenburger DA, et al. Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases. Science Advances. 7. PMID 33514545 DOI: 10.1126/sciadv.abd1707 |
0.46 |
|
| 2020 |
Kester JC, Brubaker DK, Velazquez J, Wright C, Lauffenburger DA, Griffith LG. -associated antibiotics alter human mucosal barrier functions by microbiome-independent mechanisms. Antimicrobial Agents and Chemotherapy. PMID 31988098 DOI: 10.1128/Aac.01404-19 |
0.465 |
|
| 2019 |
Dalin S, Sullivan MR, Lau AN, Grauman-Boss B, Mueller HS, Kreidl E, Fenoglio S, Luengo A, Lees JA, Vander Heiden MG, Lauffenburger DA, Hemann MT. Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance. Cancer Research. PMID 31484670 DOI: 10.1158/0008-5472.Can-19-0960 |
0.785 |
|
| 2019 |
Ahrens CC, Chiswick EL, Ravindra KC, Miller MA, Ramseier J, Isaacson KB, Lauffenburger DA, Griffith LG. Development and Application of the Metalloprotease Activity Multi-plexed Bead-based Immunoassay (MAMBI). Biochemistry. PMID 31474112 DOI: 10.1021/Acs.Biochem.9B00584 |
0.484 |
|
| 2019 |
Kinney MA, Vo LT, Frame JM, Barragan J, Conway AJ, Li S, Wong KK, Collins JJ, Cahan P, North TE, Lauffenburger DA, Daley GQ. Author Correction: A systems biology pipeline identifies regulatory networks for stem cell engineering. Nature Biotechnology. PMID 31312048 DOI: 10.1038/S41587-019-0212-1 |
0.683 |
|
| 2019 |
Kinney MA, Vo LT, Frame JM, Barragan J, Conway AJ, Li S, Wong KK, Collins JJ, Cahan P, North TE, Lauffenburger DA, Daley GQ. A systems biology pipeline identifies regulatory networks for stem cell engineering. Nature Biotechnology. 37: 810-818. PMID 31267104 DOI: 10.1038/S41587-019-0159-2 |
0.746 |
|
| 2019 |
Chang MM, Gaidukov L, Jung G, Tseng WA, Scarcelli JJ, Cornell R, Marshall JK, Lyles JL, Sakorafas P, Chu AA, Cote K, Tzvetkova B, Dolatshahi S, Sumit M, Mulukutla BC, ... Lauffenburger DA, et al. Small-molecule control of antibody N-glycosylation in engineered mammalian cells. Nature Chemical Biology. PMID 31110306 DOI: 10.1038/S41589-019-0288-4 |
0.762 |
|
| 2019 |
Sumit M, Dolatshahi S, Chu AA, Cote K, Scarcelli JJ, Marshall JK, Cornell RJ, Weiss R, Lauffenburger DA, Mulukutla BC, Figueroa B. Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses. Iscience. 12: 102-120. PMID 30682623 DOI: 10.1016/J.Isci.2019.01.006 |
0.768 |
|
| 2018 |
Yoneyama T, Gorry M, Sobo-Vujanovic A, Lin Y, Vujanovic L, Gaither-Davis A, Moss ML, Miller MA, Griffith LG, Lauffenburger DA, Stabile LP, Herman J, Vujanovic NL. ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker. Journal of Cancer. 9: 2559-2570. PMID 30026855 DOI: 10.7150/Jca.24601 |
0.481 |
|
| 2018 |
Edington CD, Chen WLK, Geishecker E, Kassis T, Soenksen LR, Bhushan BM, Freake D, Kirschner J, Maass C, Tsamandouras N, Valdez J, Cook CD, Parent T, Snyder S, Yu J, ... ... Lauffenburger DA, et al. Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies. Scientific Reports. 8: 4530. PMID 29540740 DOI: 10.1038/S41598-018-22749-0 |
0.48 |
|
| 2018 |
Clark AM, Kumar M, Wheeler S, Young C, Venkataramanan R, Stolz D, Griffith L, Lauffenburger DA, Wells A. A model of dormant-emergent metastatic breast cancer progression enabling exploration of biomarker signatures. Molecular & Cellular Proteomics : McP. PMID 29353230 DOI: 10.1074/Mcp.Ra117.000370 |
0.665 |
|
| 2018 |
Wright KD, Chadwick E, Rota C, Brown A, Stockdale L, Kieran MW, Ligon K, Goumnerova L, Lauffenburger D, Griffith L, Segal R. PCLN-07. A 3D HYDROGEL CULTURE SYSTEM FACILITATES STUDY OF PRIMARY PEDIATRIC LOW-GRADE GLIOMA CELLS IN VITRO Neuro-Oncology. 20: i156-i156. DOI: 10.1093/Neuonc/Noy059.576 |
0.458 |
|
| 2017 |
Yoneyama T, Gorry M, Miller MA, Gaither-Davis A, Lin Y, Moss ML, Griffith LG, Lauffenburger DA, Stabile LP, Herman JG, Vujanovic NL. Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates. Journal of Cancer. 8: 3916-3932. PMID 29187866 DOI: 10.7150/jca.20779 |
0.502 |
|
| 2017 |
Chen WLK, Edington C, Suter E, Yu J, Velazquez JJ, Velazquez JG, Shockley M, Large EM, Venkataramanan R, Hughes DJ, Stokes CL, Trumper DL, Carrier RL, Cirit M, Griffith LG, ... Lauffenburger DA, et al. Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter-Tissue Crosstalk. Biotechnology and Bioengineering. PMID 28667746 DOI: 10.1002/Bit.26370 |
0.472 |
|
| 2017 |
Janes KA, Chandran PL, Ford RM, Lazzara MJ, Papin JA, Peirce SM, Saucerman JJ, Lauffenburger DA. An engineering design approach to systems biology. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 28590470 DOI: 10.1039/C7Ib00014F |
0.636 |
|
| 2017 |
Sarkar U, Ravindra KC, Large E, Young CL, Rivera-Burgos D, Yu J, Cirit M, Hughes DJ, Wishnok JS, Lauffenburger DA, Griffith LG, Tannenbaum SR. Integrated assessment of diclofenac biotransformation, pharmacokinetics, and omics-based toxicity in a 3D human liver-immunocompetent co-culture system. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 28450578 DOI: 10.1124/Dmd.116.074005 |
0.631 |
|
| 2017 |
Jørgensen H, Hill AS, Beste MT, Kumar MP, Chiswick E, Fedorcsak P, Isaacson KB, Lauffenburger DA, Griffith LG, Qvigstad E. Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility. Fertility and Sterility. PMID 28433374 DOI: 10.1016/J.Fertnstert.2017.03.013 |
0.737 |
|
| 2017 |
Valdez J, Cook CD, Ahrens CC, Wang AJ, Brown A, Kumar M, Stockdale L, Rothenberg D, Renggli K, Gordon E, Lauffenburger D, White F, Griffith L. On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks. Biomaterials. 130: 90-103. PMID 28371736 DOI: 10.1016/J.Biomaterials.2017.03.030 |
0.541 |
|
| 2017 |
Cook CD, Hill AS, Guo M, Stockdale L, Papps JP, Isaacson KB, Lauffenburger DA, Griffith LG. Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 28317948 DOI: 10.1039/c6ib00245e |
0.547 |
|
| 2017 |
Moynihan KD, Opel C, Szeto G, Tzeng A, Eric Z, Engreitz J, Robert W, Rakhra K, Zhang M, Rothschilds A, Kumari S, Kelly RL, Kwan B, Abraham W, Hu K, ... ... Lauffenburger DA, et al. Abstract A52: Eradication of large established tumors with combination immunotherapy engaging innate and adaptive immunity Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-A52 |
0.77 |
|
| 2017 |
Clark AM, Wheeler SE, Young CL, Neiman JS, Pillai V, Stockdale L, Stolz D, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A. Abstract A01: Mechanical properties of matrices strongly influence spontaneous tumor dormancy and responses to chemotherapy in a 3D model of metastasis Cancer Research. 77. DOI: 10.1158/1538-7445.Epso16-A01 |
0.563 |
|
| 2016 |
Sun D, Dalin S, Hemann MT, Lauffenburger DA, Zhao B. Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations. Scientific Reports. 6: 36198. PMID 27819268 DOI: 10.1038/Srep36198 |
0.768 |
|
| 2016 |
Moynihan KD, Opel CF, Szeto GL, Tzeng A, Zhu EF, Engreitz JM, Williams RT, Rakhra K, Zhang MH, Rothschilds AM, Kumari S, Kelly RL, Kwan BH, Abraham W, Hu K, ... ... Lauffenburger DA, et al. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nature Medicine. PMID 27775706 DOI: 10.1038/Nm.4200 |
0.782 |
|
| 2016 |
Oudin MJ, Miller MA, Klazen JA, Kosciuk T, Lussiez A, Hughes SK, Tadros J, Bear JE, Lauffenburger DA, Gertler FB. MenaINV mediates synergistic crosstalk between signaling pathways driving chemotaxis and haptotaxis. Molecular Biology of the Cell. PMID 27559126 DOI: 10.1091/Mbc.E16-04-0212 |
0.311 |
|
| 2016 |
Wilson JL, Dalin S, Gosline S, Hemann M, Fraenkel E, Lauffenburger DA. Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 27315426 DOI: 10.1039/C6Ib00040A |
0.784 |
|
| 2016 |
Chitforoushzadeh Z, Ye Z, Sheng Z, LaRue S, Fry RC, Lauffenburger DA, Janes KA. TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors. Science Signaling. 9: ra59. PMID 27273097 DOI: 10.1126/Scisignal.Aad3373 |
0.767 |
|
| 2016 |
Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA. Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance. Cancer Discovery. PMID 26984351 DOI: 10.1158/2159-8290.Cd-15-0933 |
0.503 |
|
| 2016 |
Zhao B, Sedlak JC, Srinivas R, Creixell P, Pritchard JR, Tidor B, Lauffenburger DA, Hemann MT. Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution. Cell. PMID 26924578 DOI: 10.1016/J.Cell.2016.01.045 |
0.545 |
|
| 2016 |
Oudin MJ, Jonas O, Kosciuk T, Broye LC, Guido BC, Wyckoff J, Riquelme D, Lamar JM, Asokan SB, Whittaker C, Ma D, Langer R, Cima MJ, Wisinski KB, Hynes RO, ... Lauffenburger DA, et al. Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression. Cancer Discovery. PMID 26811325 DOI: 10.1158/2159-8290.Cd-15-1183 |
0.356 |
|
| 2016 |
Oudin MJ, Jonas O, Kosciuk T, Broye L, Wyckoff J, Klazen J, Lamar J, Asokan S, Whittaker C, Langer R, Cima M, Wisinski K, Hynes R, Lauffenburger D, Keely P, et al. Abstract PR15: Haptotaxis and direct remodeling of the extracellular matrix by tumor cells is important for metastasis Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-Pr15 |
0.384 |
|
| 2016 |
Clark AM, Wheeler SE, Young CL, Pillai VC, Stolz DB, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A. Abstract PR11: Elucidating candidate biomarkers of breast cancer progression and dormancy using a 3D model of metastasis Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-Pr11 |
0.553 |
|
| 2016 |
Zhao B, Hemann MT, Lauffenburger DA. Modeling tumor clonal evolution for drug combinations design Trends in Cancer. 2: 144-158. DOI: 10.1016/j.trecan.2016.02.001 |
0.507 |
|
| 2016 |
Cirit M, Griffith L, Lauffenburger D, Tannenbaum S, Hughes D, Rohatgi G. Human physiome on a chip: A platform for drug discovery and development Toxicology Letters. 258: S191-S192. DOI: 10.1016/J.Toxlet.2016.06.1703 |
0.426 |
|
| 2015 |
Yu J, Cilfone NA, Large EM, Sarkar U, Wishnok JS, Tannenbaum SR, Hughes DJ, Lauffenburger DA, Griffith LG, Stokes CL, Cirit M. Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration. Cpt: Pharmacometrics & Systems Pharmacology. 4: 585-94. PMID 26535159 DOI: 10.1002/psp4.12010 |
0.481 |
|
| 2015 |
Arnold KB, Szeto GL, Alter G, Irvine DJ, Lauffenburger DA. CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals. Science Signaling. 8: ra104. PMID 26486173 DOI: 10.1126/Scisignal.Aab0808 |
0.727 |
|
| 2015 |
Miller MA, Moss ML, Powell G, Petrovich R, Edwards L, Meyer AS, Griffith LG, Lauffenburger DA. Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain. Scientific Reports. 5: 15150. PMID 26477568 DOI: 10.1038/srep15150 |
0.51 |
|
| 2015 |
Zhao B, Hemann MT, Lauffenburger DA. Abstract A31: Combination therapies guided by evolution of tumor heterogeneity. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-A31 |
0.556 |
|
| 2014 |
Zhao B, Hemann MT, Lauffenburger DA. Reply to Azuaje: Predicting effective combined therapies for heterogeneous tumors. Proceedings of the National Academy of Sciences of the United States of America. 111: E4288. PMID 25253893 DOI: 10.1073/Pnas.1415737111 |
0.538 |
|
| 2014 |
Zhao B, Hemann MT, Lauffenburger DA. Intratumor heterogeneity alters most effective drugs in designed combinations. Proceedings of the National Academy of Sciences of the United States of America. 111: 10773-8. PMID 25002493 DOI: 10.1073/Pnas.1323934111 |
0.522 |
|
| 2014 |
Clark AM, Wheeler SE, Taylor DP, Pillai VC, Young CL, Prantil-Baun R, Nguyen T, Stolz DB, Borenstein JT, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A. A microphysiological system model of therapy for liver micrometastases. Experimental Biology and Medicine (Maywood, N.J.). 239: 1170-9. PMID 24821820 DOI: 10.1177/1535370214532596 |
0.666 |
|
| 2014 |
Ebrahimkhani MR, Young CL, Lauffenburger DA, Griffith LG, Borenstein JT. Approaches to in vitro tissue regeneration with application for human disease modeling and drug development. Drug Discovery Today. 19: 754-62. PMID 24793141 DOI: 10.1016/J.Drudis.2014.04.017 |
0.636 |
|
| 2014 |
Beste MT, Pfäffle-Doyle N, Prentice EA, Morris SN, Lauffenburger DA, Isaacson KB, Griffith LG. Molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation. Science Translational Medicine. 6: 222ra16. PMID 24500404 DOI: 10.1126/Scitranslmed.3007988 |
0.767 |
|
| 2014 |
Zhao B, Pritchard JR, Lauffenburger DA, Hemann MT. Addressing genetic tumor heterogeneity through computationally predictive combination therapy. Cancer Discovery. 4: 166-74. PMID 24318931 DOI: 10.1158/2159-8290.Cd-13-0465 |
0.534 |
|
| 2014 |
Young CL, Griffith LG, Lauffenburger DA. Evaluation of biomolecular metrics in microphysiological systems: Technical challenges associated with multiplex arrays Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2014. DOI: 10.1109/NEBEC.2014.6972992 |
0.588 |
|
| 2013 |
Wheeler SE, Borenstein JT, Clark AM, Ebrahimkhani MR, Fox IJ, Griffith L, Inman W, Lauffenburger D, Nguyen T, Pillai VC, Prantil-Baun R, Stolz DB, Taylor D, Ulrich T, Venkataramanan R, et al. All-human microphysical model of metastasis therapy. Stem Cell Research & Therapy. 4: S11. PMID 24565274 DOI: 10.1186/Scrt372 |
0.643 |
|
| 2013 |
Wilson JL, Hemann MT, Fraenkel E, Lauffenburger DA. Integrated network analyses for functional genomic studies in cancer. Seminars in Cancer Biology. 23: 213-8. PMID 23811269 DOI: 10.1016/J.Semcancer.2013.06.004 |
0.535 |
|
| 2013 |
Janes KA, Lauffenburger DA. Models of signalling networks - what cell biologists can gain from them and give to them. Journal of Cell Science. 126: 1913-21. PMID 23720376 DOI: 10.1242/jcs.112045 |
0.566 |
|
| 2013 |
Miller MA, Meyer AS, Beste MT, Lasisi Z, Reddy S, Jeng KW, Chen CH, Han J, Isaacson K, Griffith LG, Lauffenburger DA. ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: E2074-83. PMID 23674691 DOI: 10.1073/Pnas.1222387110 |
0.803 |
|
| 2013 |
Pritchard JR, Bruno PM, Hemann MT, Lauffenburger DA. Predicting cancer drug mechanisms of action using molecular network signatures. Molecular Biosystems. 9: 1604-19. PMID 23287973 DOI: 10.1039/C2Mb25459J |
0.554 |
|
| 2013 |
Pritchard JR, Bruno PM, Gilbert LA, Capron KL, Lauffenburger DA, Hemann MT. Defining principles of combination drug mechanisms of action. Proceedings of the National Academy of Sciences of the United States of America. 110: E170-9. PMID 23251029 DOI: 10.1073/Pnas.1210419110 |
0.515 |
|
| 2013 |
Chen CH, Miller MA, Sarkar A, Beste MT, Isaacson KB, Lauffenburger DA, Griffith LG, Han J. Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis. Journal of the American Chemical Society. 135: 1645-8. PMID 23157326 DOI: 10.1021/Ja307866Z |
0.754 |
|
| 2013 |
Oudin MJ, Hughes-Alford SK, Miller M, Asokan SB, Bear JE, Lauffenburger DA, Gertler FB. Abstract C41: MenaINVdysregulation of receptor tyrosine kinase signaling Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-C41 |
0.401 |
|
| 2013 |
Lauffenburger DA, Zhao B, Pritchard JR, Hemann MT. Abstract IA10: Targeting intratumoral genetic heterogeneity through rationally designed combination therapy Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-Ia10 |
0.529 |
|
| 2012 |
Yamanaka YJ, Szeto GL, Gierahn TM, Forcier TL, Benedict KF, Brefo MS, Lauffenburger DA, Irvine DJ, Love JC. Cellular barcodes for efficiently profiling single-cell secretory responses by microengraving. Analytical Chemistry. 84: 10531-6. PMID 23205933 DOI: 10.1021/Ac302264Q |
0.753 |
|
| 2012 |
Pritchard JR, Lauffenburger DA, Hemann MT. Understanding resistance to combination chemotherapy. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 15: 249-57. PMID 23164555 DOI: 10.1016/J.Drup.2012.10.003 |
0.531 |
|
| 2012 |
Kolitz SE, Lauffenburger DA. Measurement and modeling of signaling at the single-cell level. Biochemistry. 51: 7433-43. PMID 22954137 DOI: 10.1021/bi300846p |
0.314 |
|
| 2012 |
Stains CI, Tedford NC, Walkup TC, Lukovi? E, Goguen BN, Griffith LG, Lauffenburger DA, Imperiali B. Interrogating signaling nodes involved in cellular transformations using kinase activity probes. Chemistry & Biology. 19: 210-7. PMID 22365604 DOI: 10.1016/J.Chembiol.2011.11.012 |
0.476 |
|
| 2012 |
Han Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA, Love JC. Polyfunctional responses by human T cells result from sequential release of cytokines. Proceedings of the National Academy of Sciences of the United States of America. 109: 1607-12. PMID 22160692 DOI: 10.1073/Pnas.1117194109 |
0.535 |
|
| 2012 |
Hang TC, Lauffenburger DA, Griffith LG, Stolz DB. Lipids promote survival, proliferation, and maintenance of differentiation of rat liver sinusoidal endothelial cells in vitro. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G375-88. PMID 22075778 DOI: 10.1152/ajpgi.00288.2011 |
0.496 |
|
| 2012 |
Lauffenburger DA, Pritchard JR, Hemann MT. Abstract SY22-02: Mammalian functional genetic signatures identify efficacy landscapes of combination chemotherapy Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Sy22-02 |
0.526 |
|
| 2012 |
Chen CH, Miller MA, Sarkar A, Beste MT, Lauffenburger DA, Griffith LG, Han J. High-throughput mutiplexed protease activity measurement using a droplet based microfluidic platform with picoinjector Proceedings of the 16th International Conference On Miniaturized Systems For Chemistry and Life Sciences, Microtas 2012. 1504-1506. |
0.695 |
|
| 2011 |
Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, ... ... Lauffenburger DA, et al. ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein. The Journal of Biological Chemistry. 286: 40443-51. PMID 21956108 DOI: 10.1074/Jbc.M111.280495 |
0.49 |
|
| 2011 |
Pritchard JR, Gilbert LA, Meacham CE, Ricks JL, Jiang H, Lauffenburger DA, Hemann MT. Bcl-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response. Cancer Research. 71: 5850-8. PMID 21784872 DOI: 10.1158/0008-5472.Can-11-1014 |
0.578 |
|
| 2011 |
Wu S, Wells A, Griffith LG, Lauffenburger DA. Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling. Biomaterials. 32: 7524-31. PMID 21782235 DOI: 10.1016/J.Biomaterials.2011.06.050 |
0.546 |
|
| 2011 |
Chen CH, Sarkar A, Song YA, Miller MA, Kim SJ, Griffith LG, Lauffenburger DA, Han J. Enhancing protease activity assay in droplet-based microfluidics using a biomolecule concentrator. Journal of the American Chemical Society. 133: 10368-71. PMID 21671557 DOI: 10.1021/Ja2036628 |
0.444 |
|
| 2011 |
Peyton SR, Kalcioglu ZI, Cohen JC, Runkle AP, Van Vliet KJ, Lauffenburger DA, Griffith LG. Marrow-derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness. Biotechnology and Bioengineering. 108: 1181-93. PMID 21449030 DOI: 10.1002/Bit.23027 |
0.708 |
|
| 2011 |
Bagheri N, Shiina M, Lauffenburger DA, Korn WM. A dynamical systems model for combinatorial cancer therapy enhances oncolytic adenovirus efficacy by MEK-inhibition. Plos Computational Biology. 7: e1001085. PMID 21379332 DOI: 10.1371/Journal.Pcbi.1001085 |
0.53 |
|
| 2011 |
Palmer MJ, Mahajan VS, Chen J, Irvine DJ, Lauffenburger DA. Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells. Immunology and Cell Biology. 89: 581-94. PMID 21339767 DOI: 10.1038/Icb.2011.5 |
0.448 |
|
| 2011 |
Jiang H, Pritchard JR, Williams RT, Lauffenburger DA, Hemann MT. A mammalian functional-genetic approach to characterizing cancer therapeutics. Nature Chemical Biology. 7: 92-100. PMID 21186347 DOI: 10.1038/Nchembio.503 |
0.55 |
|
| 2011 |
Miller MA, Barkal L, Jeng K, Herrlich A, Moss M, Griffith LG, Lauffenburger DA. Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 422-38. PMID 21180771 DOI: 10.1039/c0ib00083c |
0.477 |
|
| 2010 |
Spangler JB, Neil JR, Abramovitch S, Yarden Y, White FM, Lauffenburger DA, Wittrup KD. Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling. Proceedings of the National Academy of Sciences of the United States of America. 107: 13252-7. PMID 20616078 DOI: 10.1073/Pnas.0913476107 |
0.528 |
|
| 2010 |
Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA. Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation. Molecular Biosystems. 6: 1195-206. PMID 20361094 DOI: 10.1039/B926287C |
0.51 |
|
| 2010 |
Ciaccio MF, Wagner JP, Chuu CP, Lauffenburger DA, Jones RB. Systems analysis of EGF receptor signaling dynamics with microwestern arrays. Nature Methods. 7: 148-55. PMID 20101245 DOI: 10.1038/Nmeth.1418 |
0.784 |
|
| 2010 |
Shiina M, Bagheri N, Lauffenburger D, Korn WM. Abstract 3494: Experimentally validated modeling for optimizing therapeutic combinations of oncolytic adenoviruses and MEK inhibitor Cancer Research. 70: 3494-3494. DOI: 10.1158/1538-7445.Am10-3494 |
0.528 |
|
| 2010 |
Das A, Lauffenburger D, Asada H, Kamm R. Determining Cell Fate Transition Probabilities to VEGF/Ang 1 Levels: Relating Computational Modeling to Microfluidic Angiogenesis Studies Cellular and Molecular Bioengineering. 3: 345-360. DOI: 10.1007/S12195-010-0146-7 |
0.322 |
|
| 2009 |
Cosgrove BD, Alexopoulos LG, Saez-Rodriguez J, Griffith LG, Lauffenburger DA. A multipathway phosphoproteomic signaling network model of idiosyncratic drug- and inflammatory cytokine-induced toxicity in human hepatocytes. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 5452-5. PMID 19964679 DOI: 10.1109/IEMBS.2009.5334019 |
0.516 |
|
| 2009 |
Platt MO, Wilder CL, Wells A, Griffith LG, Lauffenburger DA. Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells. Stem Cells (Dayton, Ohio). 27: 2804-14. PMID 19750537 DOI: 10.1002/Stem.215 |
0.559 |
|
| 2009 |
Pritchard JR, Cosgrove BD, Hemann MT, Griffith LG, Wands JR, Lauffenburger DA. Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death. Molecular Cancer Therapeutics. 8: 2183-92. PMID 19671754 DOI: 10.1158/1535-7163.Mct-08-1203 |
0.682 |
|
| 2009 |
Platt MO, Roman AJ, Wells A, Lauffenburger DA, Griffith LG. Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells. Journal of Cellular Physiology. 221: 306-17. PMID 19544388 DOI: 10.1002/Jcp.21854 |
0.525 |
|
| 2009 |
Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. Toxicology and Applied Pharmacology. 237: 317-30. PMID 19362101 DOI: 10.1016/J.Taap.2009.04.002 |
0.475 |
|
| 2008 |
Cosgrove BD, Cheng C, Pritchard JR, Stolz DB, Lauffenburger DA, Griffith LG. An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha. Hepatology (Baltimore, Md.). 48: 276-88. PMID 18536058 DOI: 10.1002/hep.22335 |
0.452 |
|
| 2008 |
Palmer MJ, Mahajan VS, Trajman LC, Irvine DJ, Lauffenburger DA, Chen J. Interleukin-7 receptor signaling network: an integrated systems perspective. Cellular & Molecular Immunology. 5: 79-89. PMID 18445337 DOI: 10.1038/Cmi.2008.10 |
0.48 |
|
| 2008 |
Cosgrove BD, Griffith LG, Lauffenburger DA. Fusing Tissue Engineering and Systems Biology Toward Fulfilling Their Promise Cellular and Molecular Bioengineering. 1: 33-41. DOI: 10.1007/S12195-008-0007-9 |
0.416 |
|
| 2008 |
Miller-Jensen K, Lauffenburger DA, Schaffer DV. Systems biology approaches to studying intracellular signaling interactions between virus and host Aiche Annual Meeting, Conference Proceedings. |
0.43 |
|
| 2007 |
Zugates GT, Tedford NC, Zumbuehl A, Jhunjhunwala S, Kang CS, Griffith LG, Lauffenburger DA, Langer R, Anderson DG. Gene delivery properties of end-modified poly(beta-amino ester)s. Bioconjugate Chemistry. 18: 1887-96. PMID 17929884 DOI: 10.1021/Bc7002082 |
0.492 |
|
| 2007 |
Miller-Jensen K, Janes KA, Brugge JS, Lauffenburger DA. Common effector processing mediates cell-specific responses to stimuli. Nature. 448: 604-8. PMID 17637676 DOI: 10.1038/Nature06001 |
0.634 |
|
| 2007 |
Wille L, Kemp ML, Sandy P, Lewis CL, Lauffenburger DA. Epi-allelic Erk1 and Erk2 knockdown series for quantitative analysis of T cell Erk regulation and IL-2 production. Molecular Immunology. 44: 3085-91. PMID 17418417 DOI: 10.1016/J.Molimm.2007.02.008 |
0.611 |
|
| 2007 |
Kharait S, Hautaniemi S, Wu S, Iwabu A, Lauffenburger DA, Wells A. Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility. Bmc Systems Biology. 1: 9. PMID 17408516 DOI: 10.1186/1752-0509-1-9 |
0.313 |
|
| 2007 |
Kemp ML, Wille L, Lewis CL, Nicholson LB, Lauffenburger DA. Quantitative network signal combinations downstream of TCR activation can predict IL-2 production response. Journal of Immunology (Baltimore, Md. : 1950). 178: 4984-92. PMID 17404280 DOI: 10.4049/Jimmunol.178.8.4984 |
0.645 |
|
| 2007 |
Kumar N, Wolf-Yadlin A, White FM, Lauffenburger DA. Modeling HER2 effects on cell behavior from mass spectrometry phosphotyrosine data. Plos Computational Biology. 3: e4. PMID 17206861 DOI: 10.1371/Journal.Pcbi.0030004 |
0.345 |
|
| 2007 |
Green J, Zugates G, Tedford N, Huang Y, Griffith L, Lauffenburger D, Sawicki J, Langer R, Anderson D. Inside Front Cover: Combinatorial Modification of Degradable Polymers Enables Transfection of Human Cells Comparable to Adenovirus (Adv. Mater. 19/2007) Advanced Materials. 19: NA-NA. DOI: 10.1002/Adma.200790075 |
0.458 |
|
| 2007 |
Green JJ, Zugates GT, Tedford NC, Huang YH, Griffith LG, Lauffenburger DA, Sawicki JA, Langer R, Anderson DG. Combinatorial modification of degradable polymers enables transfection of human cells comparable to adenovirus Advanced Materials. 19: 2836-2842. DOI: 10.1002/Adma.200700371 |
0.526 |
|
| 2006 |
Wolf-Yadlin A, Kumar N, Zhang Y, Hautaniemi S, Zaman M, Kim HD, Grantcharova V, Lauffenburger DA, White FM. Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Molecular Systems Biology. 2: 54. PMID 17016520 DOI: 10.1038/Msb4100094 |
0.323 |
|
| 2006 |
Miller-Jensen K, Janes KA, Wong YL, Griffith LG, Lauffenburger DA. Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis. Journal of Cell Science. 119: 3788-98. PMID 16940353 DOI: 10.1242/Jcs.03102 |
0.684 |
|
| 2006 |
Kumar N, Hendriks BS, Janes KA, de Graaf D, Lauffenburger DA. Applying computational modeling to drug discovery and development. Drug Discovery Today. 11: 806-11. PMID 16935748 DOI: 10.1016/j.drudis.2006.07.010 |
0.538 |
|
| 2006 |
Wells A, Harms B, Iwabu A, Koo L, Smith K, Griffith L, Lauffenburger DA. Motility signaled from the EGF receptor and related systems Methods in Molecular Biology (Clifton, N.J.). 327: 159-177. PMID 16780220 DOI: 10.1385/1-59745-012-X:159 |
0.52 |
|
| 2006 |
Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK. The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell. 124: 1225-39. PMID 16564013 DOI: 10.1016/j.cell.2006.01.041 |
0.566 |
|
| 2006 |
Janes KA, Lauffenburger DA. A biological approach to computational models of proteomic networks. Current Opinion in Chemical Biology. 10: 73-80. PMID 16406679 DOI: 10.1016/j.cbpa.2005.12.016 |
0.526 |
|
| 2006 |
Tedford N, Fang J, Domansky K, Griffith LG, Lauffenburger DA. 396. Quantitative Analysis of Non-Viral Gene Therapy in a Three-Dimensional Liver Bioreactor Molecular Therapy. 13: S151-S152. DOI: 10.1016/j.ymthe.2006.08.458 |
0.414 |
|
| 2005 |
Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science (New York, N.Y.). 310: 1646-53. PMID 16339439 DOI: 10.1126/Science.1116598 |
0.58 |
|
| 2005 |
Rao BM, Driver I, Lauffenburger DA, Wittrup KD. High-affinity CD25-binding IL-2 mutants potently stimulate persistent T cell growth. Biochemistry. 44: 10696-701. PMID 16060678 DOI: 10.1021/Bi050436X |
0.458 |
|
| 2005 |
Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK. A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Molecular & Cellular Proteomics : McP. 4: 1569-90. PMID 16030008 DOI: 10.1074/mcp.M500158-MCP200 |
0.607 |
|
| 2005 |
Viswanathan S, Davey RE, Cheng D, Raghu RC, Lauffenburger DA, Zandstra PW. Clonal evolution of stem and differentiated cells can be predicted by integrating cell-intrinsic and -extrinsic parameters. Biotechnology and Applied Biochemistry. 42: 119-31. PMID 15882145 DOI: 10.1042/Ba20040207 |
0.68 |
|
| 2005 |
Varga CM, Tedford NC, Thomas M, Klibanov AM, Griffith LG, Lauffenburger DA. Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes. Gene Therapy. 12: 1023-32. PMID 15815703 DOI: 10.1038/Sj.Gt.3302495 |
0.48 |
|
| 2005 |
Shults MD, Janes KA, Lauffenburger DA, Imperiali B. A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates. Nature Methods. 2: 277-83. PMID 15782220 DOI: 10.1038/Nmeth747 |
0.532 |
|
| 2005 |
Rao BM, Lauffenburger DA, Wittrup KD. Integrating cell-level kinetic modeling into the design of engineered protein therapeutics. Nature Biotechnology. 23: 191-4. PMID 15696150 DOI: 10.1038/Nbt1064 |
0.499 |
|
| 2005 |
Monine MI, Berezhkovskii AM, Joslin EJ, Wiley HS, Lauffenburger DA, Shvartsman SY. Ligand accumulation in autocrine cell cultures. Biophysical Journal. 88: 2384-90. PMID 15653719 DOI: 10.1529/Biophysj.104.051425 |
0.784 |
|
| 2005 |
Woolf PJ, Prudhomme W, Daheron L, Daley GQ, Lauffenburger DA. Bayesian analysis of signaling networks governing embryonic stem cell fate decisions. Bioinformatics (Oxford, England). 21: 741-53. PMID 15479714 DOI: 10.1093/Bioinformatics/Bti056 |
0.743 |
|
| 2004 |
Janes KA, Kelly JR, Gaudet S, Albeck JG, Sorger PK, Lauffenburger DA. Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 11: 544-61. PMID 15579231 DOI: 10.1089/1066527041887258 |
0.603 |
|
| 2004 |
Rao BM, Driver I, Lauffenburger DA, Wittrup KD. Interleukin 2 (IL-2) variants engineered for increased IL-2 receptor alpha-subunit affinity exhibit increased potency arising from a cell surface ligand reservoir effect. Molecular Pharmacology. 66: 864-9. PMID 15385640 DOI: 10.1124/Mol.66.4.864 |
0.485 |
|
| 2004 |
Lu H, Koo LY, Wang WM, Lauffenburger DA, Griffith LG, Jensen KF. Microfluidic shear devices for quantitative analysis of cell adhesion. Analytical Chemistry. 76: 5257-64. PMID 15362881 DOI: 10.1021/Ac049837T |
0.52 |
|
| 2004 |
Prudhomme W, Daley GQ, Zandstra P, Lauffenburger DA. Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling. Proceedings of the National Academy of Sciences of the United States of America. 101: 2900-5. PMID 14978270 DOI: 10.1073/Pnas.0308768101 |
0.673 |
|
| 2004 |
Shvartsman SY, Wiley HS, Lauffenburger DA. Epidermal growth factor receptor signaling in tissues Ieee Control Systems Magazine. 24: 53-61. DOI: 10.1109/Mcs.2004.1316653 |
0.523 |
|
| 2004 |
Janes KA, Albeck JG, Gaudet S, Nielsen UB, Sorger PK, Lauffenburger DA, Yaffe MB. MULTIVARIATE APPROACHES FOR REVEALING BIOLOGICAL SIGNAL-RESPONSE RELATIONSHIPS RELEVANT TO SEPSIS Shock. 21: 3. DOI: 10.1097/00024382-200403001-00009 |
0.532 |
|
| 2003 |
Rao BM, Girvin AT, Ciardelli T, Lauffenburger DA, Wittrup KD. Interleukin-2 mutants with enhanced alpha-receptor subunit binding affinity. Protein Engineering. 16: 1081-7. PMID 14983090 DOI: 10.1093/Protein/Gzg111 |
0.458 |
|
| 2003 |
Viswanathan S, Benatar T, Mileikovsky M, Lauffenburger DA, Nagy A, Zandstra PW. Supplementation-dependent differences in the rates of embryonic stem cell self-renewal, differentiation, and apoptosis. Biotechnology and Bioengineering. 84: 505-17. PMID 14574685 DOI: 10.1002/Bit.10799 |
0.675 |
|
| 2003 |
Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Molecular & Cellular Proteomics : McP. 2: 463-73. PMID 12832460 DOI: 10.1074/Mcp.M300045-Mcp200 |
0.581 |
|
| 2003 |
Sarkar CA, Lowenhaupt K, Wang PJ, Horan T, Lauffenburger DA. Parsing the effects of binding, signaling, and trafficking on the mitogenic potencies of granulocyte colony-stimulating factor analogues. Biotechnology Progress. 19: 955-64. PMID 12790662 DOI: 10.1021/Bp020017G |
0.69 |
|
| 2003 |
Ricci MS, Sarkar CA, Fallon EM, Lauffenburger DA, Brems DN. pH Dependence of structural stability of interleukin-2 and granulocyte colony-stimulating factor. Protein Science : a Publication of the Protein Society. 12: 1030-8. PMID 12717025 DOI: 10.1110/Ps.0230103 |
0.642 |
|
| 2003 |
Sarkar CA, Lauffenburger DA. Cell-level pharmacokinetic model of granulocyte colony-stimulating factor: implications for ligand lifetime and potency in vivo. Molecular Pharmacology. 63: 147-58. PMID 12488547 DOI: 10.1124/Mol.63.1.147 |
0.688 |
|
| 2003 |
Wiley HS, Shvartsman SY, Lauffenburger DA. Computational modeling of the EGF-receptor system: a paradigm for systems biology. Trends in Cell Biology. 13: 43-50. PMID 12480339 DOI: 10.1016/S0962-8924(02)00009-0 |
0.52 |
|
| 2002 |
Sarkar CA, Lowenhaupt K, Horan T, Boone TC, Tidor B, Lauffenburger DA. Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching" Nature Biotechnology. 20: 908-913. PMID 12161759 DOI: 10.1038/Nbt725 |
0.663 |
|
| 2002 |
Shvartsman SY, Muratov CB, Lauffenburger DA. Modeling and computational analysis of EGF receptor-mediated cell communication in Drosophila oogenesis. Development (Cambridge, England). 129: 2577-89. PMID 12015287 |
0.546 |
|
| 2002 |
Viswanathan S, Benatar T, Rose-John S, Lauffenburger DA, Zandstra PW. Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6. Stem Cells (Dayton, Ohio). 20: 119-38. PMID 11897869 DOI: 10.1634/Stemcells.20-2-119 |
0.714 |
|
| 2002 |
Koo LY, Irvine DJ, Mayes AM, Lauffenburger DA, Griffith LG. Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus. Journal of Cell Science. 115: 1423-33. PMID 11896190 |
0.633 |
|
| 2002 |
Shvartsman SY, Hagan MP, Yacoub A, Dent P, Wiley HS, Lauffenburger DA. Autocrine loops with positive feedback enable context-dependent cell signaling. American Journal of Physiology. Cell Physiology. 282: C545-59. PMID 11832340 DOI: 10.1152/Ajpcell.00260.2001 |
0.579 |
|
| 2001 |
Shvartsman SY, Wiley HS, Deen WM, Lauffenburger DA. Spatial range of autocrine signaling: modeling and computational analysis. Biophysical Journal. 81: 1854-67. PMID 11566760 DOI: 10.1016/S0006-3495(01)75837-7 |
0.558 |
|
| 2001 |
Orsello CE, Lauffenburger DA, Hammer DA. Molecular properties in cell adhesion: a physical and engineering perspective. Trends in Biotechnology. 19: 310-6. PMID 11451473 DOI: 10.1016/S0167-7799(01)01692-4 |
0.499 |
|
| 2001 |
Asthagiri AR, Lauffenburger DA. A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (MAPK) pathway model. Biotechnology Progress. 17: 227-39. PMID 11312698 DOI: 10.1021/Bp010009K |
0.62 |
|
| 2001 |
Lauffenburger DA, Griffith LG. Who's got pull around here? Cell organization in development and tissue engineering. Proceedings of the National Academy of Sciences of the United States of America. 98: 4282-4. PMID 11296276 DOI: 10.1073/pnas.081083698 |
0.451 |
|
| 2000 |
Asthagiri AR, Lauffenburger DA. Bioengineering models of cell signaling. Annual Review of Biomedical Engineering. 2: 31-53. PMID 11701506 DOI: 10.1146/Annurev.Bioeng.2.1.31 |
0.642 |
|
| 2000 |
Schaffer DV, Lauffenburger DA. Targeted synthetic gene delivery vectors. Current Opinion in Molecular Therapeutics. 2: 155-61. PMID 11249636 |
0.451 |
|
| 2000 |
Haugh JM, Wells A, Lauffenburger DA. Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: mechanistic insights and predictions for molecular interventions. Biotechnology and Bioengineering. 70: 225-38. PMID 10972934 DOI: 10.1002/1097-0290(20001020)70:2<225::Aid-Bit12>3.0.Co;2-S |
0.642 |
|
| 2000 |
Zandstra PW, Lauffenburger DA, Eaves CJ. A ligand-receptor signaling threshold model of stem cell differentiation control: A biologically conserved mechanism applicable to hematopoiesis Blood. 96: 1215-1222. PMID 10942360 DOI: 10.1182/Blood.V96.4.1215.H8001215_1215_1222 |
0.656 |
|
| 2000 |
Zandstra PW, Le HV, Daley GQ, Griffith LG, Lauffenburger DA. Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation. Biotechnology and Bioengineering. 69: 607-17. PMID 10918135 DOI: 10.1002/1097-0290(20000920)69:6<607::Aid-Bit4>3.0.Co;2-F |
0.735 |
|
| 2000 |
Maheshwari G, Brown G, Lauffenburger DA, Wells A, Griffith LG. Cell adhesion and motility depend on nanoscale RGD clustering. Journal of Cell Science. 113: 1677-86. PMID 10769199 |
0.533 |
|
| 2000 |
Schaffer DV, Fidelman NA, Dan N, Lauffenburger DA. Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. Biotechnology and Bioengineering. 67: 598-606. PMID 10649234 DOI: 10.1002/(Sici)1097-0290(20000305)67:5<598::Aid-Bit10>3.0.Co;2-G |
0.455 |
|
| 1999 |
Wells A, Ware MF, Allen FD, Lauffenburger DA. Shaping up for shipping out: PLC? signaling of morphology changes in EGF-stimulated fibroblast migration Cytoskeleton. 44: 227-233. PMID 10602252 DOI: 10.1002/(Sici)1097-0169(199912)44:4<227::Aid-Cm1>3.0.Co;2-B |
0.303 |
|
| 1999 |
Haugh JM, Huang AC, Wiley HS, Wells A, Lauffenburger DA. Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts. The Journal of Biological Chemistry. 274: 34350-60. PMID 10567412 DOI: 10.1074/Jbc.274.48.34350 |
0.607 |
|
| 1999 |
Asthagiri AR, Nelson CM, Horwitz AF, Lauffenburger DA. Quantitative relationship among integrin-ligand binding, adhesion, and signaling via focal adhesion kinase and extracellular signal-regulated kinase 2. The Journal of Biological Chemistry. 274: 27119-27. PMID 10480927 DOI: 10.1074/Jbc.274.38.27119 |
0.628 |
|
| 1999 |
Zhang S, Yan L, Altman M, Lässle M, Nugent H, Frankel F, Lauffenburger DA, Whitesides GM, Rich A. Biological surface engineering: a simple system for cell pattern formation. Biomaterials. 20: 1213-20. PMID 10395390 DOI: 10.1016/S0142-9612(99)00014-9 |
0.368 |
|
| 1999 |
Lauffenburger DA, Schaffer DV. The matrix delivers. Nature Medicine. 5: 733-4. PMID 10395312 DOI: 10.1038/10451 |
0.382 |
|
| 1999 |
Maheshwari G, Wells A, Griffith LG, Lauffenburger DA. Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration. Biophysical Journal. 76: 2814-23. PMID 10233097 DOI: 10.1016/S0006-3495(99)77435-7 |
0.524 |
|
| 1999 |
Asthagiri AR, Horwitz AF, Lauffenburger DA. A rapid and sensitive quantitative kinase activity assay using a convenient 96-well format. Analytical Biochemistry. 269: 342-7. PMID 10222008 DOI: 10.1006/Abio.1999.4055 |
0.617 |
|
| 1999 |
Palecek SP, Horwitz AF, Lauffenburger DA. Kinetic Model for Integrin-mediated Adhesion Release during Cell Migration Annals of Biomedical Engineering. 27: 219-235. PMID 10199699 |
0.564 |
|
| 1999 |
Haugh JM, Schooler K, Wells A, Wiley HS, Lauffenburger DA. Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway. The Journal of Biological Chemistry. 274: 8958-65. PMID 10085141 DOI: 10.1074/Jbc.274.13.8958 |
0.627 |
|
| 1999 |
Palecek SP, Cox EA, Huttenlocher A, Lauffenburger DA, Horwitz AF. Integrin Adhesion in Cell Migration Advances in Molecular and Cell Biology. 28: 367-388. DOI: 10.1016/S1569-2558(08)60054-5 |
0.549 |
|
| 1998 |
Haugh JM, Lauffenburger DA. Analysis of receptor internalization as a mechanism for modulating signal transduction. Journal of Theoretical Biology. 195: 187-218. PMID 9822563 DOI: 10.1006/Jtbi.1998.0791 |
0.63 |
|
| 1998 |
Lauffenburger DA, Fallon EM, Haugh JM. Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics. Chemistry & Biology. 5: R257-63. PMID 9818145 DOI: 10.1016/S1074-5521(98)90110-7 |
0.613 |
|
| 1998 |
Schaffer DV, Lauffenburger DA. Optimization of cell surface binding enhances efficiency and specificity of molecular conjugate gene delivery. The Journal of Biological Chemistry. 273: 28004-9. PMID 9774415 DOI: 10.1074/Jbc.273.43.28004 |
0.463 |
|
| 1997 |
Huttenlocher A, Palecek SP, Lu Q, Zhang W, Mellgren RL, Lauffenburger DA, Ginsberg MH, Horwitz AF. Regulation of cell migration by the calcium-dependent protease calpain Journal of Biological Chemistry. 272: 32719-32722. PMID 9407041 DOI: 10.1074/Jbc.272.52.32719 |
0.564 |
|
| 1997 |
Kuo SC, Hammer DA, Lauffenburger DA. Simulation of detachment of specifically bound particles from surfaces by shear flow. Biophysical Journal. 73: 517-31. PMID 9199814 DOI: 10.1016/S0006-3495(97)78090-1 |
0.448 |
|
| 1997 |
Haugh JM, Lauffenburger DA. Physical modulation of intracellular signaling processes by locational regulation. Biophysical Journal. 72: 2014-31. PMID 9129805 DOI: 10.1016/S0006-3495(97)78846-5 |
0.635 |
|
| 1997 |
Palecek SP, Loftust JC, Ginsberg MH, Lauffenburger DA, Horwitz AF. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness Nature. 385: 537-540. PMID 9020360 DOI: 10.1038/385537A0 |
0.55 |
|
| 1997 |
Schaffer DV, Neve RL, Lauffenburger DA. Use of the green fluorescent protein as a quantitative reporter of epidermal growth factor receptor-mediated gene delivery Tissue Engineering. 3: 53-63. DOI: 10.1089/Ten.1997.3.53 |
0.473 |
|
| 1997 |
Palecek SP, Loftus JC, Ginsberg MH, Lauffenburger DA, Horwitz AF. Erratum: Integrin–ligand binding properties govern cell migration speed through cell–substratum adhesiveness Nature. 388: 210-210. DOI: 10.1038/40687 |
0.518 |
|
| 1996 |
Robinson AS, Lauffenburger DA. Model for ER chaperone dynamics and secretory protein interactions Aiche Journal. 42: 1443-1453. DOI: 10.1002/Aic.690420525 |
0.524 |
|
| 1994 |
Schmidt CE, Chen T, Lauffenburger DA. Simulation of integrin-cytoskeletal interactions in migrating fibroblasts Biophysical Journal. 67: 461-474. PMID 7522599 DOI: 10.1016/S0006-3495(94)80502-8 |
0.485 |
|
| 1994 |
Linderman JJ, Mahama PA, Forsten KE, Lauffenburger DA. Diffusion and Probability in Receptor Binding and Signaling Advances in Chemical Engineering. 19: 51-127. DOI: 10.1016/S0065-2377(08)60213-6 |
0.511 |
|
| 1993 |
DiMilla PA, Stone JA, Quinn JA, Albelda SM, Lauffenburger DA. Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength. The Journal of Cell Biology. 122: 729-37. PMID 8335696 DOI: 10.1083/Jcb.122.3.729 |
0.762 |
|
| 1993 |
Schmidt CE, Horwitz AF, Lauffenburger DA, Sheetz MP. Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated Journal of Cell Biology. 123: 977-991. PMID 8227153 DOI: 10.1083/Jcb.123.4.977 |
0.527 |
|
| 1992 |
Ford RM, Lauffenburger DA. A simple expression for quantifying bacterial chemotaxis using capillary assay data: application to the analysis of enhanced chemotactic responses from growth-limited cultures. Mathematical Biosciences. 109: 127-49. PMID 1600283 DOI: 10.1016/0025-5564(92)90042-U |
0.553 |
|
| 1992 |
DiMilla PA, Quinn JA, Albelda SM, Lauffenburger DA. Measurement of individual cell migration parameters for human tissue cells Aiche Journal. 38: 1092-1104. DOI: 10.1002/Aic.690380712 |
0.775 |
|
| 1991 |
Ford RM, Phillips BR, Quinn JA, Lauffenburger DA. Stopped-flow chamber and image analysis system for quantitative characterization of bacterial population migration: Motility and chemotaxis ofEscherichia coli K12 to fucose. Microbial Ecology. 22: 127-38. PMID 24194332 DOI: 10.1007/Bf02540219 |
0.626 |
|
| 1991 |
Ford RM, Lauffenburger DA. Measurement of bacterial random motility and chemotaxis coefficients: II. Application of single-cell-based mathematical model. Biotechnology and Bioengineering. 37: 661-72. PMID 18600657 DOI: 10.1002/bit.260370708 |
0.525 |
|
| 1991 |
Ford RM, Phillips BR, Quinn JA, Lauffenburger DA. Measurement of bacterial random motility and chemotaxis coefficients: I. Stopped-flow diffusion chamber assay. Biotechnology and Bioengineering. 37: 647-60. PMID 18600656 DOI: 10.1002/Bit.260370707 |
0.636 |
|
| 1991 |
Ford RM, Lauffenburger DA. Analysis of chemotactic bacterial distributions in population migration assays using a mathematical model applicable to steep or shallow attractant gradients. Bulletin of Mathematical Biology. 53: 721-49. PMID 1933037 DOI: 10.1007/BF02461551 |
0.516 |
|
| 1991 |
DiMilla PA, Barbee K, Lauffenburger DA. Mathematical model for the effects of adhesion and mechanics on cell migration speed. Biophysical Journal. 60: 15-37. PMID 1883934 DOI: 10.1016/S0006-3495(91)82027-6 |
0.743 |
|
| 1991 |
DiMilla PA, Stone JA, Albelda SM, Lauffenburger DA, Quinn JA. Measurement of Cell Adhesion and Migration on Protein-Coated Surfaces Mrs Proceedings. 252. DOI: 10.1557/Proc-252-205 |
0.766 |
|
| 1991 |
FORD R, LAUFFENBURGER D. Analysis of chemotactic bacterial distributions in population migration assays using a mathematical model applicable to steep or shallow attractant gradients Bulletin of Mathematical Biology. 53: 721-749. DOI: 10.1016/S0092-8240(05)80230-7 |
0.467 |
|
| 1990 |
Cozens-Roberts C, Quinn JA, Lauffenburger DA. Receptor-mediated cell attachment and detachment kinetics. II. Experimental model studies with the radial-flow detachment assay. Biophysical Journal. 58: 857-72. PMID 2174272 DOI: 10.1016/S0006-3495(90)82431-0 |
0.501 |
|
| 1990 |
Cozens-Roberts C, Lauffenburger DA, Quinn JA. Receptor-mediated cell attachment and detachment kinetics. I. Probabilistic model and analysis. Biophysical Journal. 58: 841-56. PMID 2174271 DOI: 10.1016/S0006-3495(90)82430-9 |
0.52 |
|
| 1989 |
Buettner HM, Lauffenburger DA, Zigmond SH. Measurement of leukocyte motility and chemotaxis parameters with the Millipore filter assay. Journal of Immunological Methods. 123: 25-37. PMID 2794528 DOI: 10.1016/0022-1759(89)90026-4 |
0.645 |
|
| 1989 |
Hammer DA, Lauffenburger DA. A dynamical model for receptor-mediated cell adhesion to surfaces in viscous shear flow. Cell Biophysics. 14: 139-73. PMID 2472206 DOI: 10.1007/BF02797131 |
0.485 |
|
| 1989 |
Tranquillo RT, Fisher ES, Farrell BE, Lauffenburger DA. A stochastic model for chemosensory cell movement: application to neutrophil and macrophage persistence and orientation Mathematical and Computer Modelling. 12: 1179. DOI: 10.1016/0025-5564(88)90071-5 |
0.519 |
|
| 1989 |
Rivero MA, Tranquillo RT, Buettner HM, Lauffenburger DA. Transport models for chemotactic cell populations based on individual cell behavior Chemical Engineering Science. 44: 2881-2897. DOI: 10.1016/0009-2509(89)85098-5 |
0.734 |
|
| 1989 |
Buettner HM, Lauffenburger DA, Zigmond SH. Cell transport in the millipore filter assay Aiche Journal. 35: 459-465. DOI: 10.1002/aic.690350314 |
0.593 |
|
| 1988 |
Tranquillo RT, Lauffenburger DA, Zigmond SH. A stochastic model for leukocyte random motility and chemotaxis based on receptor binding fluctuations. The Journal of Cell Biology. 106: 303-9. PMID 3339093 DOI: 10.1083/Jcb.106.2.303 |
0.574 |
|
| 1988 |
Lauffenburger DA, Tranquillo RT, Zigmond SH. Concentration gradients of chemotactic factors in chemotaxis assays. Methods in Enzymology. 162: 85-101. PMID 3226329 DOI: 10.1016/0076-6879(88)62067-2 |
0.529 |
|
| 1988 |
Tranquillo RT, Zigmond SH, Lauffenburger DA. Measurement of the chemotaxis coefficient for human neutrophils in the under-agarose migration assay. Cell Motility and the Cytoskeleton. 11: 1-15. PMID 3208295 DOI: 10.1002/Cm.970110102 |
0.587 |
|
| 1988 |
Linderman JJ, Lauffenburger DA. Analysis of intracellular receptor/ligand sorting in endosomes. Journal of Theoretical Biology. 132: 203-45. PMID 2850411 DOI: 10.1016/S0022-5193(88)80157-7 |
0.538 |
|
| 1987 |
Tranquillo RT, Lauffenburger DA. Stochastic model of leukocyte chemosensory movement Journal of Mathematical Biology. 25: 229-262. PMID 3625051 DOI: 10.1007/Bf00276435 |
0.556 |
|
| 1987 |
Lauffenburger DA, Rivero M, Kelly F, Ford R, DiRIENZO J. Bacterial chemotaxis: cell flux model, parameter measurement, population dynamics, and genetic manipulation Annals of the New York Academy of Sciences. 506: 281-295. PMID 3324858 DOI: 10.1111/J.1749-6632.1987.Tb23827.X |
0.516 |
|
| 1987 |
Lauffenburger DA, Linderman J, Berkowitz L. Analysis of mammalian cell growth factor receptor dynamics. Annals of the New York Academy of Sciences. 506: 147-62. PMID 3324852 DOI: 10.1111/j.1749-6632.1987.tb23816.x |
0.56 |
|
| 1987 |
Hammer DA, Lauffenburger DA. A dynamical model for receptor-mediated cell adhesion to surfaces. Biophysical Journal. 52: 475-87. PMID 2820521 DOI: 10.1016/S0006-3495(87)83236-8 |
0.49 |
|
| 1987 |
Hammer DA, Lauffenburger DA. Effects of Nonspecific Cell/Surface Interactions on Cell Affinity Chromatographic Separations Mrs Proceedings. 110. DOI: 10.1557/Proc-110-739 |
0.505 |
|
| 1987 |
Staffeld PO, Lauffenburger DA, Quinn J. Mathematical analysis of cell transport phenomena: Bacterial chemotaxis in the capillary assay Chemical Engineering Communications. 58: 339-351. DOI: 10.1080/00986448708911975 |
0.442 |
|
| 1987 |
TRANQUILLO R, LAUFFENBURGER D. A unifying hypothesis for leukocyte random motility and chemotaxis based on stochastic cell-receptor sensing Cell Biology International Reports. 11: 259. DOI: 10.1016/0309-1651(87)90073-7 |
0.549 |
|
| 1987 |
TRANQUILLO R, LAUFFENBURGER D. Measurement of the random motility and chemotaxis coefficients appearing in cell population migration theory for human PMN in the linear under-agarose assay Cell Biology International Reports. 11: 240. DOI: 10.1016/0309-1651(87)90054-3 |
0.516 |
|
| 1987 |
Hammer DA, Linderman JJ, Graves DJ, Lauffenburger DA. Affinity Chromatography for Cell Separation: Mathematical Model and Experimental Analysis Biotechnology Progress. 3: 189-204. DOI: 10.1002/Btpr.5420030310 |
0.67 |
|
| 1986 |
Linderman JJ, Lauffenburger DA. Analysis of intracellular receptor/ligand sorting. Calculation of mean surface and bulk diffusion times within a sphere. Biophysical Journal. 50: 295-305. PMID 3741985 |
0.528 |
|
| 1986 |
Tranquillo RT, Lauffenburger DA. Consequences of chemosensory phenomena for leukocyte chemotactic orientation Cell Biophysics. 8: 1-46. PMID 2421906 DOI: 10.1007/BF02788459 |
0.556 |
|
| 1984 |
LAUFFENBURGER D, KENNEDY C, ARIS R. Traveling bands of chemotactic bacteria in the context of population growth Bulletin of Mathematical Biology. 46: 19-40. DOI: 10.1016/S0092-8240(84)80033-6 |
0.397 |
|
| 1984 |
Lauffenburger D, Grady M, Keller KH. An hypothesis for approaching swarms of myxobacteria Journal of Theoretical Biology. 110: 257-274. DOI: 10.1016/S0022-5193(84)80058-2 |
0.632 |
|
| 1984 |
Lauffenburger D, Kennedy CR, Aris R. Traveling bands of chemotactic bacteria in the context of population growth Bulletin of Mathematical Biology. 46: 19-40. DOI: 10.1007/bf02463721 |
0.397 |
|
| 1982 |
Lauffenburger D, Aris R, Keller K. Effects of cell motility and chemotaxis on microbial population growth. Biophysical Journal. 40: 209-19. PMID 7183335 DOI: 10.1016/S0006-3495(82)84476-7 |
0.707 |
|
| 1981 |
Lauffenburger D, Aris R, Keller KH. Effects of random motility on growth of bacterial populations. Microbial Ecology. 7: 207-27. PMID 24227496 DOI: 10.1007/Bf02010304 |
0.696 |
|
| 1979 |
Lauffenburger D, Keller KH. Effects of leukocyte random motility and chemotaxis in tissue inflammatory response. Journal of Theoretical Biology. 81: 475-503. PMID 395370 DOI: 10.1016/0022-5193(79)90047-X |
0.633 |
|
| 1979 |
Lauffenburger D, Aris R. Measurement of leukocyte motility and chemotaxis parameters using a quantitative analysis of the under-agarose migration assay Mathematical Biosciences. 44: 121-138. DOI: 10.1016/0025-5564(79)90032-4 |
0.42 |
|
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