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Jeanne A. Hardy, Ph.D. - Publications

Affiliations: 
1994-2000 Chemistry University of California, Berkeley, Berkeley, CA, United States 
 2005- Chemistry University of Massachusetts, Amherst, Amherst, MA 
Area:
structural biology, with a major emphasis on electron microscopy
Website:
https://hardylab.chem.umass.edu/people/
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49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Cruz KG, Hill Eron M, Makhaik S, Savinov S, Hardy JA. A Non-Active-Site Inhibitor with Selectivity for Zika Virus NS2B-NS3 Protease. Acs Infectious Diseases. PMID 38265226 DOI: 10.1021/acsinfecdis.3c00330  0.33
2021 Araya LE, Soni IV, Hardy JA, Julien O. Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling. Acs Chemical Biology. PMID 34553588 DOI: 10.1021/acschembio.1c00456  0.518
2021 Soni IV, Hardy JA. Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence. Biochemistry. PMID 34472839 DOI: 10.1021/acs.biochem.1c00459  0.414
2021 Anson F, Thayumanavan S, Hardy JA. Exogenous Introduction of Initiator and Executioner Caspases Results in Different Apoptotic Outcomes. Jacs Au. 1: 1240-1256. PMID 34467362 DOI: 10.1021/jacsau.1c00261  0.468
2020 Arias-Arias JL, MacPherson DJ, Hill ME, Hardy JA, Mora-Rodríguez R. A fluorescence activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques. The Journal of Biological Chemistry. PMID 31919100 DOI: 10.1074/Jbc.Ra119.011319  0.777
2020 Hardy J. Targeting Rare Conformational States to Achieve Selective Caspase Protease Inhibition Biophysical Journal. 118: 160a-161a. DOI: 10.1016/J.Bpj.2019.11.993  0.411
2019 Pham B, Eron SJ, Hill ME, Li X, Fahie MA, Hardy JA, Chen M. A Nanopore Approach for Analysis of Caspase-7 Activity in Cell Lysates. Biophysical Journal. PMID 31427065 DOI: 10.1016/J.Bpj.2019.07.045  0.833
2019 Okerberg ES, Dagbay KB, Green JL, Soni I, Aban A, Nomanbhoy TK, Savinov SN, Hardy JA, Kozarich JW. Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP-Binding Site at the Dimer Interface of Procaspase-6. Biochemistry. PMID 31095371 DOI: 10.1021/Acs.Biochem.9B00290  0.802
2018 Hill ME, Yildiz M, Hardy JA. Cysteine Disulfide Traps Reveal Distinct Conformational Ensembles in Dengue Virus NS2B-NS3 Protease. Biochemistry. PMID 30472839 DOI: 10.1021/Acs.Biochem.8B00978  0.78
2018 MacPherson DJ, Mills CL, Ondrechen MJ, Hardy JA. Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis. The Journal of Biological Chemistry. PMID 30420425 DOI: 10.1074/Jbc.Ra118.005914  0.774
2018 Hardy JA. Fighting Kinase Drug Resistance with Caspase Activators. Cell Chemical Biology. 25: 927-928. PMID 30118670 DOI: 10.1016/J.Chembiol.2018.08.001  0.333
2018 Hill ME, Kumar A, Wells JA, Hobman TC, Julien O, Hardy JA. The unique cofactor region of Zika virus NS2B-NS3 protease facilitates cleavage of key host proteins. Acs Chemical Biology. PMID 30080377 DOI: 10.1021/Acschembio.8B00508  0.724
2018 Tubeleviciute-Aydin A, Zhou L, Sharma G, Soni IV, Savinov SN, Hardy JA, LeBlanc AC. Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity. Scientific Reports. 8: 4428. PMID 29535332 DOI: 10.1038/S41598-018-22283-Z  0.486
2018 Huber KL, Serrano BP, Hardy JA. Caspase-9 CARD: core domain interactions require a properly formed active site. The Biochemical Journal. PMID 29500231 DOI: 10.1042/Bcj20170913  0.822
2018 Eron SJ, MacPherson DJ, Dagbay KB, Hardy JA. Multiple mechanisms of zinc-mediated inhibition for the apoptotic caspases -3, -6, -7, & -8. Acs Chemical Biology. PMID 29364645 DOI: 10.1021/Acschembio.8B00064  0.824
2018 Serrano BP, Hardy JA. Phosphorylation by protein kinase A disassembles the caspase-9 core. Cell Death and Differentiation. PMID 29352269 DOI: 10.1038/S41418-017-0052-9  0.837
2017 Serrano BP, Szydlo HS, Alfandari DR, Hardy JA. Active-site adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9. The Journal of Biological Chemistry. PMID 29066624 DOI: 10.1074/Jbc.M117.811976  0.824
2017 Raghupathi K, Eron SJ, Anson F, Hardy JA, Thayumanavan S. Utilizing Inverse Emulsion Polymerization to Generate Responsive Nanogels for Cytosolic Protein Delivery. Molecular Pharmaceutics. PMID 29053277 DOI: 10.1021/Acs.Molpharmaceut.7B00643  0.784
2017 Dagbay KB, Hardy JA. Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions. Proceedings of the National Academy of Sciences of the United States of America. PMID 28864531 DOI: 10.1073/Pnas.1704640114  0.816
2017 Dagbay KB, Hill ME, Barrett E, Hardy JA. Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency. Biochemistry. PMID 28726391 DOI: 10.1021/Acs.Biochem.7B00357  0.812
2017 Dagbay KB, Bolik-Coulon N, Savinov SN, Hardy JA. Caspase-6 Undergoes a Distinct Helix-Strand Interconversion Upon Substrate Binding. The Journal of Biological Chemistry. PMID 28154009 DOI: 10.1074/Jbc.M116.773499  0.852
2016 Eron SJ, Raghupathi K, Hardy JA. Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms. Structure (London, England : 1993). PMID 27889207 DOI: 10.1016/J.Str.2016.11.001  0.849
2016 Hill ME, MacPherson DJ, Wu P, Julien O, Wells JA, Hardy JA. Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chemical Biology. PMID 27032039 DOI: 10.1021/Acschembio.5B00971  0.854
2015 Wu Y, Lindblad JL, Garnett J, Kamber Kaya HE, Xu D, Zhao Y, Flores ER, Hardy J, Bergmann A. Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila. Cell Death and Differentiation. PMID 26542461 DOI: 10.1038/Cdd.2015.144  0.446
2015 Ventura J, Eron SJ, Gonzalez-Toro DC, Raghupathi K, Wang F, Hardy JA, Thayumanavan S. Reactive Self-Assembly of Polymers and Proteins to Reversibly Silence a Killer Protein. Biomacromolecules. PMID 26331939 DOI: 10.1021/Acs.Biomac.5B00779  0.811
2015 Kim CS, Mout R, Zhao Y, Yeh YC, Tang R, Jeong Y, Duncan B, Hardy JA, Rotello VM. Co-delivery of protein and small molecule therapeutics using nanoparticle-stabilized nanocapsules. Bioconjugate Chemistry. 26: 950-4. PMID 25894332 DOI: 10.1021/Acs.Bioconjchem.5B00146  0.308
2015 Hardy JA. A Multi-Pronged Approach for Uncovering Allosteric Networks in Caspases Biophysical Journal. 108: 381a. DOI: 10.1016/J.Bpj.2014.11.2087  0.605
2014 Dagbay K, Eron SJ, Serrano BP, Velázquez-Delgado EM, Zhao Y, Lin D, Vaidya S, Hardy JA. A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases. Methods in Enzymology. 544: 215-49. PMID 24974292 DOI: 10.1016/B978-0-12-417158-9.00009-1  0.762
2013 Yildiz M, Ghosh S, Bell JA, Sherman W, Hardy JA. Allosteric inhibition of the NS2B-NS3 protease from dengue virus. Acs Chemical Biology. 8: 2744-52. PMID 24164286 DOI: 10.1021/Cb400612H  0.798
2013 Tang R, Kim CS, Solfiell DJ, Rana S, Mout R, Velázquez-Delgado EM, Chompoosor A, Jeong Y, Yan B, Zhu ZJ, Kim C, Hardy JA, Rotello VM. Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules. Acs Nano. 7: 6667-73. PMID 23815280 DOI: 10.1021/Nn402753Y  0.771
2013 Wu P, Nicholls SB, Hardy JA. A tunable, modular approach to fluorescent protease-activated reporters. Biophysical Journal. 104: 1605-14. PMID 23561537 DOI: 10.1016/J.Bpj.2013.01.058  0.798
2013 Nicholls SB, Hardy JA. Structural basis of fluorescence quenching in caspase activatable-GFP. Protein Science : a Publication of the Protein Society. 22: 247-57. PMID 23139158 DOI: 10.1002/Pro.2188  0.783
2012 Huber KL, Ghosh S, Hardy JA. Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface. Biopolymers. 98: 451-65. PMID 23203690 DOI: 10.1002/Bip.22080  0.812
2012 Jabaiah AM, Getz JA, Witkowski WA, Hardy JA, Daugherty PS. Identification of protease exosite-interacting peptides that enhance substrate cleavage kinetics. Biological Chemistry. 393: 933-41. PMID 22944693 DOI: 10.1515/Hsz-2012-0162  0.804
2012 Velázquez-Delgado EM, Hardy JA. Zinc-mediated allosteric inhibition of caspase-6. The Journal of Biological Chemistry. 287: 36000-11. PMID 22891250 DOI: 10.1074/Jbc.M112.397752  0.839
2012 Huber KL, Hardy JA. Mechanism of zinc-mediated inhibition of caspase-9. Protein Science : a Publication of the Protein Society. 21: 1056-65. PMID 22573662 DOI: 10.1002/Pro.2090  0.83
2012 Velázquez-Delgado EM, Hardy JA. Phosphorylation regulates assembly of the caspase-6 substrate-binding groove. Structure (London, England : 1993). 20: 742-51. PMID 22483120 DOI: 10.1016/J.Str.2012.02.003  0.848
2012 López GE, Colón-Díaz I, Cruz A, Ghosh S, Nicholls SB, Viswanathan U, Hardy JA, Auerbach SM. Modeling nonaqueous proton wires built from helical peptides: biased proton transfer driven by helical dipoles. The Journal of Physical Chemistry. A. 116: 1283-8. PMID 22188565 DOI: 10.1021/Jp210208M  0.733
2011 Witkowski WA, Hardy JA. A designed redox-controlled caspase. Protein Science : a Publication of the Protein Society. 20: 1421-31. PMID 21674661 DOI: 10.1002/Pro.673  0.851
2011 Nicholls SB, Chu J, Abbruzzese G, Tremblay KD, Hardy JA. Mechanism of a genetically encoded dark-to-bright reporter for caspase activity. The Journal of Biological Chemistry. 286: 24977-86. PMID 21558267 DOI: 10.1074/Jbc.M111.221648  0.779
2011 Vaidya S, Hardy JA. Caspase-6 latent state stability relies on helical propensity. Biochemistry. 50: 3282-7. PMID 21381717 DOI: 10.1021/Bi2001664  0.741
2011 Vaidya S, Velázquez-Delgado EM, Abbruzzese G, Hardy JA. Substrate-induced conformational changes occur in all cleaved forms of caspase-6. Journal of Molecular Biology. 406: 75-91. PMID 21111746 DOI: 10.1016/J.Jmb.2010.11.031  0.835
2009 Hardy JA, Wells JA. Dissecting an allosteric switch in caspase-7 using chemical and mutational probes. The Journal of Biological Chemistry. 284: 26063-9. PMID 19581639 DOI: 10.1074/Jbc.M109.001826  0.522
2009 Witkowski WA, Hardy JA. L2' loop is critical for caspase-7 active site formation. Protein Science : a Publication of the Protein Society. 18: 1459-68. PMID 19530232 DOI: 10.1002/Pro.151  0.818
2009 Huber KL, Olson KD, Hardy JA. Robust production of a peptide library using methodological synchronization. Protein Expression and Purification. 67: 139-47. PMID 19457455 DOI: 10.1016/J.Pep.2009.05.006  0.719
2006 Hardy J. Discovery and exploitation of allosteric sites for control of protein function Nanomedicine: Nanotechnology, Biology and Medicine. 2: 291. DOI: 10.1016/J.Nano.2006.10.074  0.345
2004 Hardy JA, Wells JA. Searching for new allosteric sites in enzymes. Current Opinion in Structural Biology. 14: 706-15. PMID 15582395 DOI: 10.1016/J.Sbi.2004.10.009  0.398
2004 Hardy JA, Lam J, Nguyen JT, O'Brien T, Wells JA. Discovery of an allosteric site in the caspases. Proceedings of the National Academy of Sciences of the United States of America. 101: 12461-6. PMID 15314233 DOI: 10.1073/Pnas.0404781101  0.497
2001 Cicero MP, Hubl ST, Harrison CJ, Littlefield O, Hardy JA, Nelson HC. The wing in yeast heat shock transcription factor (HSF) DNA-binding domain is required for full activity. Nucleic Acids Research. 29: 1715-23. PMID 11292844 DOI: 10.1093/Nar/29.8.1715  0.307
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