Heung B. Jeon, Ph.D. - Publications

2000 Case Western Reserve University, Cleveland Heights, OH, United States 

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 You SY, Park YS, Jeon HJ, Cho DH, Jeon HB, Kim SH, Chang JW, Kim JS, Oh JS. Beclin-1 knockdown shows abscission failure but not autophagy defect during oocyte meiotic maturation. Cell Cycle (Georgetown, Tex.). 0. PMID 27149384 DOI: 10.1080/15384101.2016.1181235  0.32
2016 Jin HJ, Kwon JH, Kim M, Bae YK, Choi SJ, Oh W, Yang YS, Jeon HB. Downregulation of Melanoma Cell Adhesion Molecule (MCAM/CD146) Accelerates Cellular Senescence in Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells. Stem Cells Translational Medicine. PMID 26941359 DOI: 10.5966/sctm.2015-0109  0.32
2016 Lee JB, Kim JE, Bae MS, Park SA, Balikov DA, Sung HJ, Jeon HB, Park HK, Um SH, Lee KS, Kwon IK. Development of poly(ε-Caprolactone) scaffold loaded with simvastatin and beta-cyclodextrin modified hydroxyapatite inclusion complex for bone tissue engineering Polymers. 8. DOI: 10.3390/polym8020049  0.36
2016 Hamer P, Frey A, Abdesselam A, Adachi I, Aihara H, Al Said S, Arinstein K, Asner DM, Aushev T, Ayad R, Babu V, Badhrees I, Bakich AM, Barberio E, Bhuyan B, ... ... Jeon HB, et al. Search for B0 →π-τ+ντ with hadronic tagging at Belle Physical Review D - Particles, Fields, Gravitation and Cosmology. 93. DOI: 10.1103/PhysRevD.93.032007  0.32
2016 Glattauer R, Schwanda C, Abdesselam A, Adachi I, Adamczyk K, Aihara H, Al Said S, Asner DM, Aushev T, Ayad R, Aziz T, Badhrees I, Bakich AM, Bansal V, Barberio E, ... ... Jeon HB, et al. Measurement of the decay B →dℓνℓ in fully reconstructed events and determination of the Cabibbo-Kobayashi-Maskawa matrix element |Vcb | Physical Review D - Particles, Fields, Gravitation and Cosmology. 93. DOI: 10.1103/PhysRevD.93.032006  0.32
2015 Jeong SY, Ha J, Lee M, Jin HJ, Kim DH, Choi SJ, Oh W, Yang YS, Kim JS, Kim BG, Chang JH, Cho DH, Jeon HB. Autocrine Action of Thrombospondin-2 Determines the Chondrogenic Differentiation Potential and Suppresses Hypertrophic Maturation of Human Umbilical Cord Blood-derived Mesenchymal Stem Cells. Stem Cells (Dayton, Ohio). PMID 26235673 DOI: 10.1002/stem.2120  0.32
2015 Kim ES, Jeon HB, Lim H, Shin JH, Park SJ, Jo YK, Oh W, Yang YS, Cho DH, Kim JY. Conditioned Media from Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Inhibits Melanogenesis by Promoting Proteasomal Degradation of MITF. Plos One. 10: e0128078. PMID 26024475 DOI: 10.1371/journal.pone.0128078  0.32
2015 Ko WK, Heo DN, Moon HJ, Lee SJ, Bae MS, Lee JB, Sun IC, Jeon HB, Park HK, Kwon IK. The effect of gold nanoparticle size on osteogenic differentiation of adipose-derived stem cells. Journal of Colloid and Interface Science. 438: 68-76. PMID 25454427 DOI: 10.1016/j.jcis.2014.08.058  0.36
2015 Lee N, Kim I, Park S, Han D, Ha S, Kwon M, Kim J, Byun SH, Oh W, Jeon HB, Kweon DH, Cho JY, Yoon K. Creatine inhibits adipogenesis by downregulating insulin-induced activation of the phosphatidylinositol 3-kinase signaling pathway. Stem Cells and Development. 24: 983-94. PMID 25428599 DOI: 10.1089/scd.2014.0130  0.32
2015 Min BS, Jeon HB, Jeong TU, Kim SY. Energetic polymeric networks prepared via a solvent- and catalyst-free thermal cycloaddition of azide-bearing polymers with alkynes and hydroxyl-isocyanate addition reactions Polymer Chemistry. 6: 7913-7920. DOI: 10.1039/c5py01276g  1
2015 Baek JY, Kwon HW, Myung SJ, Park JJ, Kim MY, Rathwell DCK, Jeon HB, Seeberger PH, Kim KS. Directing effect by remote electron-withdrawing protecting groups at O-3 or O-4 position of donors in glucosylations and galactosylations Tetrahedron. 71: 5315-5320. DOI: 10.1016/j.tet.2015.06.014  1
2015 Kwon OW, Lee K, Roh YH, Huang JX, Choi SK, Kim YK, Jeon HB, Oh YR, Lee YK, Kang BO, Chung E, Park JG, Lee Y. Genietutor: A computer-assisted second-language learning system based on spoken language understanding Natural Language Dialog Systems and Intelligent Assistants. 257-262. DOI: 10.1007/978-3-319-19291-8_26  0.6
2014 Kim ES, Park SJ, Goh MJ, Na YJ, Jo DS, Jo YK, Shin JH, Choi ES, Lee HK, Kim JY, Jeon HB, Kim JC, Cho DH. Mitochondrial dynamics regulate melanogenesis through proteasomal degradation of MITF via ROS-ERK activation. Pigment Cell & Melanoma Research. 27: 1051-62. PMID 25065405 DOI: 10.1111/pcmr.12298  0.32
2014 Lee M, Jeong SY, Ha J, Kim M, Jin HJ, Kwon SJ, Chang JW, Choi SJ, Oh W, Yang YS, Kim JS, Jeon HB. Low immunogenicity of allogeneic human umbilical cord blood-derived mesenchymal stem cells in vitro and in vivo. Biochemical and Biophysical Research Communications. 446: 983-9. PMID 24657442 DOI: 10.1016/j.bbrc.2014.03.051  0.32
2014 Jeong J, Kim K, Lee R, Lee S, Kim H, Jung H, Kadir MA, Jang Y, Jeon HB, Matyjaszewski K, Chang T, Paik HJ. Preparation and analysis of bicyclic polystyrene Macromolecules. 47: 3791-3796. DOI: 10.1021/ma500391z  1
2014 Jeon HB, Kim KT, Kim SH. Selective oxidation of sulfides to sulfoxides with cyanuric chloride and urea-hydrogen peroxide adduct Tetrahedron Letters. 55: 3905-3908. DOI: 10.1016/j.tetlet.2014.05.080  1
2014 Jeong J, Kim H, Lee S, Choi H, Jeon HB, Paik Hj. Improved synthesis of bicyclic polystyrenes by ATRP and "click" reaction Polymer (United Kingdom). DOI: 10.1016/j.polymer.2015.04.004  1
2014 Lee DH, Kim KT, Jung H, Kim SH, Park S, Jeon HB, Paik Hj, Min BS, Kim W. Characterization of 1,2,3-triazole crosslinked polymers based on azide chain-ends prepolymers and a dipolarophile curing agent as propellant binders: The effect of a plasticizer Journal of the Taiwan Institute of Chemical Engineers. DOI: 10.1016/j.jtice.2014.08.002  1
2014 Park SW, Lee D, Choi YS, Jeon HB, Lee CH, Moon JH, Kwon IK. Mesoporous TiO2 implants for loading high dosage of antibacterial agent Applied Surface Science. 303: 140-146. DOI: 10.1016/j.apsusc.2014.02.111  0.36
2014 Lee DH, Kim KT, Jang Y, Lee S, Jeon HB, Paik HJ, Min BS, Kim W. 1,2,3-triazole crosslinked polymers as binders for solid rocket propellants Journal of Applied Polymer Science. 131. DOI: 10.1002/app.40594  1
2013 Jin HJ, Bae YK, Kim M, Kwon SJ, Jeon HB, Choi SJ, Kim SW, Yang YS, Oh W, Chang JW. Comparative analysis of human mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord blood as sources of cell therapy. International Journal of Molecular Sciences. 14: 17986-8001. PMID 24005862 DOI: 10.3390/ijms140917986  0.32
2013 Jeong SY, Kim DH, Ha J, Jin HJ, Kwon SJ, Chang JW, Choi SJ, Oh W, Yang YS, Kim G, Kim JS, Yoon JR, Cho DH, Jeon HB. Thrombospondin-2 secreted by human umbilical cord blood-derived mesenchymal stem cells promotes chondrogenic differentiation. Stem Cells (Dayton, Ohio). 31: 2136-48. PMID 23843355 DOI: 10.1002/stem.1471  0.32
2013 Jang Y, Kim KT, Jeon HB. Deoxygenation of sulfoxides to sulfides with thionyl chloride and triphenylphosphine: competition with the pummerer reaction. The Journal of Organic Chemistry. 78: 6328-31. PMID 23724848 DOI: 10.1021/jo4008157  1
2013 Kim SH, Jeong GH, Choi D, Yoon S, Jeon HB, Lee SM, Kim SW. Synthesis of noble metal/graphene nanocomposites without surfactants by one-step reduction of metal salt and graphene oxide. Journal of Colloid and Interface Science. 389: 85-90. PMID 23026300 DOI: 10.1016/j.jcis.2012.08.064  1
2013 Kim KH, Jung DY, Lee D, Lee HJ, Park SY, Koo MW, Kim JH, Park Js, Jeon HB, Lee YK. Implementation of a large-scale language model adaptation in a cloud environment Multimedia Tools and Applications. 1-17. DOI: 10.1007/s11042-013-1787-z  0.32
2013 Jung DY, Lee HJ, Park SY, Koo MW, Kim JH, Park JS, Jeon HB, Lee YK. Implementation of a large-scale language model in a cloud environment for human-robot interaction Lecture Notes in Electrical Engineering. 253: 957-965. DOI: 10.1007/978-94-007-6996-0-101  0.32
2012 Kim JY, Kim DH, Kim JH, Lee D, Jeon HB, Kwon SJ, Kim SM, Yoo YJ, Lee EH, Choi SJ, Seo SW, Lee JI, Na DL, Yang YS, Oh W, et al. Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid-β plaques. Cell Death and Differentiation. 19: 680-91. PMID 22015609 DOI: 10.1038/cdd.2011.140  0.32
2012 Lim SS, Sarker S, Yoon S, Nath NCD, Kim YJ, Jeon HB, Lee JJ. A series of N-Alkylimidazolium propylhexanamide iodide for dye-sensitized solar cells Bulletin of the Korean Chemical Society. 33: 1480-1484. DOI: 10.5012/bkcs.2012.33.5.1480  1
2012 Kwon M, Jang Y, Yoon S, Yang D, Jeon HB. Unusual Cu(I)-catalyzed 1,3-dipolar cycloaddition of acetylenic amides: Formation of bistriazoles Tetrahedron Letters. 53: 1606-1609. DOI: 10.1016/j.tetlet.2012.01.069  1
2011 Kim SM, Kim DS, Jeong CH, Kim DH, Kim JH, Jeon HB, Kwon SJ, Jeun SS, Yang YS, Oh W, Chang JW. CXC chemokine receptor 1 enhances the ability of human umbilical cord blood-derived mesenchymal stem cells to migrate toward gliomas. Biochemical and Biophysical Research Communications. 407: 741-6. PMID 21439934 DOI: 10.1016/j.bbrc.2011.03.093  0.32
2011 Park S, Yang D, Kim KT, Jeon HB. Synthesis of 2-arylacrylic esters from aryl methyl ketones via Wittig reaction/singlet oxygen ene reaction Tetrahedron Letters. 52: 6578-6580. DOI: 10.1016/j.tetlet.2011.09.127  1
2010 Kim JY, Jeon HB, Yang YS, Oh W, Chang JW. Application of human umbilical cord blood-derived mesenchymal stem cells in disease models. World Journal of Stem Cells. 2: 34-8. PMID 21607114 DOI: 10.4252/wjsc.v2.i2.34  0.32
2010 Jeon HB, Jang Y. Reversible inactivation of bovine plasma amine oxidase by cysteamine and related analogs. Biochemical and Biophysical Research Communications. 403: 442-6. PMID 21094148 DOI: 10.1016/j.bbrc.2010.11.052  1
2010 Oh KB, Jeon HB, Han YR, Lee YJ, Park J, Lee SH, Yang D, Kwon M, Shin J, Lee HS. Bromophenols as Candida albicans isocitrate lyase inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 6644-8. PMID 20888765 DOI: 10.1016/j.bmcl.2010.09.015  1
2010 Kim JY, Kim DH, Kim DS, Kim JH, Jeong SY, Jeon HB, Lee EH, Yang YS, Oh W, Chang JW. Galectin-3 secreted by human umbilical cord blood-derived mesenchymal stem cells reduces amyloid-beta42 neurotoxicity in vitro. Febs Letters. 584: 3601-8. PMID 20655311 DOI: 10.1016/j.febslet.2010.07.028  0.32
2010 Yang D, Jeon HB. Convenient N-formylation of amines in dimethylformamide with methyl benzoate under microwave irradiation Bulletin of the Korean Chemical Society. 31: 1424-1426. DOI: 10.5012/bkcs.2010.31.5.1424  1
2010 Yang D, Kwon M, Jang Y, Jeon HB. A convenient and efficient synthesis of C-carbamoyl-1,2,3-triazoles from alkyl bromide by a one-pot sequential addition: Conversion of ester to amide using Zr(Ot-Bu)4 Tetrahedron Letters. 51: 3691-3695. DOI: 10.1016/j.tetlet.2010.05.046  1
2009 Oh KB, Lee JH, Lee JW, Yoon KM, Chung SC, Jeon HB, Shin J, Lee HS. Synthesis and antimicrobial activities of halogenated bis(hydroxyphenyl)methanes. Bioorganic & Medicinal Chemistry Letters. 19: 945-8. PMID 19097894 DOI: 10.1016/j.bmcl.2008.11.089  1
2009 Jeon HB, Posner GH. New A-ring analogs of the hormone 1α,25-dihydroxyvitamin D3: (2′-hydroxymethyl)tetrahydrofuro[1,2-a]-25-hydroxyvitamin D3 Tetrahedron. 65: 1235-1240. DOI: 10.1016/j.tet.2008.12.034  1
2008 Kim KS, Fulse DB, Baek JY, Lee BY, Jeon HB. Stereoselective direct glycosylation with anomeric hydroxy sugars by activation with phthalic anhydride and trifluoromethanesulfonic anhydride involving glycosyl phthalate intermediates. Journal of the American Chemical Society. 130: 8537-47. PMID 18528988 DOI: 10.1021/ja710935z  0.32
2008 Kim KS, Jeon HB. Lactonization-mediated glycosylations and their application to oligosaccharide synthesis. Chemical Record (New York, N.Y.). 8: 46-65. PMID 18302265 DOI: 10.1002/tcr.20138  1
2008 Kwon JS, Jeon HB, Yang SI, Oh JJ, Joo SW. Adsorption of (S)-(+)-O-acetylmandelic acid on gold nanoparticle surfaces investigated by surface-enhanced Raman scattering Chemical Physics Letters. 467: 136-139. DOI: 10.1016/j.cplett.2008.11.003  1
2008 Kim KS, Jeon HB. Glycoside Synthesis from 1-Oxygen Substituted Glycosyl Donors: Anomeric Transglycosylation Handbook of Chemical Glycosylation: Advances in Stereoselectivity and Therapeutic Relevance. 185-223. DOI: 10.1002/9783527621644.ch3c  1
2007 Fulse DB, Jeon HB, Kim KS. Synthesis of tri-, hexa-, and nonasaccharide subunits of the atypical O-antigen polysaccharide of the lipopolysaccharide from Danish Helicobacter pylori strains. The Journal of Organic Chemistry. 72: 9963-72. PMID 18004867 DOI: 10.1021/jo701531x  0.32
2007 Jeon HB, Choi ES, Yoon JH, Hwang JH, Chang JW, Lee EK, Choi HW, Park ZY, Yoo YJ. A proteomics approach to identify the ubiquitinated proteins in mouse heart. Biochemical and Biophysical Research Communications. 357: 731-6. PMID 17451654 DOI: 10.1016/j.bbrc.2007.04.015  0.32
2007 Kim KS, Jeon HB. 2′-Carboxybenzyl glycosides: A novel type of glycosyl donors and their application to oligosaccharide synthesis Acs Symposium Series. 960: 134-149.  1
2006 Baek JY, Choi TJ, Jeon HB, Kim KS. A highly reactive and stereoselective beta-mannopyranosylation system: mannosyl 4-pentenoate/PhSeOTf. Angewandte Chemie (International Ed. in English). 45: 7436-40. PMID 17039555 DOI: 10.1002/anie.200602642  1
2006 Lee YJ, Lee BY, Jeon HB, Kim KS. Total synthesis of agelagalastatin. Organic Letters. 8: 3971-4. PMID 16928051 DOI: 10.1021/ol061444o  1
2006 Sinishtaj S, Jeon HB, Dolan P, Kensler TW, Posner GH. Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1α,25-dihydroxyvitamin D3 Bioorganic and Medicinal Chemistry. 14: 6341-6348. PMID 16765598 DOI: 10.1016/j.bmc.2006.05.050  1
2006 Lee YJ, Baek JY, Lee BY, Kang SS, Park HS, Jeon HB, Kim KS. 2'-Carboxybenzyl glycosides: glycosyl donors for C-glycosylation and conversion into other glycosyl donors. Carbohydrate Research. 341: 1708-16. PMID 16616900 DOI: 10.1016/j.carres.2006.03.014  1
2006 Lee BR, Jeon JM, Jung JH, Jeon HB, Kim KS. Synthesis of the tetrasaccharide repeat unit of the O-antigen polysaccharide from Escherichia coli O77 employing the 2′-carboxybenzyl glycoside Canadian Journal of Chemistry. 84: 506-515. DOI: 10.1139/V06-030  1
2006 Choi TJ, Baek JY, Jeon HB, Kim KS. A new efficient glycosylation method employing glycosyl pentenoates and PhSeOTf Tetrahedron Letters. 47: 9191-9194. DOI: 10.1016/j.tetlet.2006.10.158  1
2006 Lee BY, Park SR, Jeon HB, Kim KS. A new solvent system for efficient synthesis of 1,2,3-triazoles Tetrahedron Letters. 47: 5105-5109. DOI: 10.1016/j.tetlet.2006.05.079  1
2006 Zhao S, Jeon HB, Nadkarni DV, Sayre LM. Acid-catalyzed rearrangement of 1-benzyl-2-methyl-3-piperidone to 1-benzyl-2-acetylpyrrolidine Tetrahedron. 62: 6361-6369. DOI: 10.1016/j.tet.2006.04.038  1
2005 Lee YJ, Lee K, Jung EH, Jeon HB, Kim KS. Acceptor-dependent stereoselective glycosylation: 2'-CB glycoside-mediated direct beta-D-arabinofuranosylation and efficient synthesis of the octaarabinofuranoside in mycobacterial cell wall. Organic Letters. 7: 3263-6. PMID 16018636 DOI: 10.1021/ol0510668  0.32
2005 Chang YK, Lee BY, Kim DJ, Lee GS, Jeon HB, Kim KS. An efficient synthesis of valienamine via ring-closing metathesis. The Journal of Organic Chemistry. 70: 3299-302. PMID 15823000 DOI: 10.1021/jo047735x  0.32
2005 Cho BH, Kim JH, Jeon HB, Kim KS. A new efficient and practical synthesis of 2-deoxy-L-ribose Tetrahedron. 61: 4341-4346. DOI: 10.1016/j.tet.2005.03.001  1
2005 Lee YJ, Lee K, Jung SI, Jeon HB, Kim KS. Synthesis of enantiopure cyclitols from (±)-3-bromocyclohexene mediated by intramolecular oxyselenenylation employing (S,S)-hydrobenzoin and (S)-mandelic acid as chiral sources Tetrahedron. 61: 1987-2001. DOI: 10.1016/j.tet.2005.01.003  1
2005 Kwon SY, Lee BY, Jeon HB, Kim KS. Glycosylation with glycosyl p-bromophenyl phthalates as new efficient glycosyl donors Bulletin of the Korean Chemical Society. 26: 815-818.  1
2004 Posner GH, Jeon HB, Sarjeant A, Riccio ES, Doppalapudi RS, Kapetanovic IM, Saha U, Dolan P, Kensler TW. Low-calcemic, efficacious, 1α,25-dihydroxyvitamin D 3 analog QW-1624F 2-2: Calcemic dose-response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry Steroids. 69: 757-762. PMID 15579327 DOI: 10.1016/j.steroids.2004.09.004  1
2004 O'Connell KM, Langley DB, Shepard EM, Duff AP, Jeon HB, Sun G, Freeman HC, Guss JM, Sayre LM, Dooley DM. Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation. Biochemistry. 43: 10965-78. PMID 15323556 DOI: 10.1021/bi0492004  1
2004 Posner GH, Crawford KR, Yang HW, Kahraman M, Jeon HB, Li H, Lee JK, Suh BC, Hatcher MA, Labonte T, Usera A, Dolan PM, Kensler TW, Peleg S, Jones G, et al. Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-Sulfone analogs of the hormone 1α,25-dihydroxyvitamin D3 Journal of Steroid Biochemistry and Molecular Biology. 89: 5-12. PMID 15225738 DOI: 10.1016/j.jsbmb.2004.03.044  1
2004 Qiao C, Jeon HB, Sayre LM. Selective inhibition of bovine plasma amine oxidase by homopropargylamine, a new inactivator motif. Journal of the American Chemical Society. 126: 8038-45. PMID 15212554 DOI: 10.1021/ja049568o  1
2004 Suh BC, Jeon H, Posner GH, Silverman SM. Vitamin D side chain triazole analogs via cycloaddition 'click' chemistry Tetrahedron Letters. 45: 4623-4625. DOI: 10.1016/j.tetlet.2004.04.118  1
2003 Jeon HB, Lee Y, Qiao C, Huang H, Sayre LM. Inhibition of bovine plasma amine oxidase by 1,4-diamino-2-butenes and -2-butynes. Bioorganic & Medicinal Chemistry. 11: 4631-41. PMID 14527560 DOI: 10.1016/S0968-0896(03)00521-2  1
2003 Jeon HB, Sayre LM. Highly potent propargylamine and allylamine inhibitors of bovine plasma amine oxidase. Biochemical and Biophysical Research Communications. 304: 788-94. PMID 12727226 DOI: 10.1016/S0006-291X(03)00681-8  1
2003 Jeon HB, Sun G, Sayre LM. Inactivation of bovine plasma amine oxidase by 4-aryloxy-2-butynamines and related analogs. Biochimica Et Biophysica Acta. 1647: 343-54. PMID 12686156 DOI: 10.1016/S1570-9639(03)00093-1  1
2002 Posner GH, Jeon HB, Ploypradith P, Paik IH, Borstnik K, Xie S, Shapiro TA. Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents. Journal of Medicinal Chemistry. 45: 3824-8. PMID 12190305 DOI: 10.1021/jm020210h  1
2001 Chang JW, Jeon HB, Lee JH, Yoo JS, Chun JS, Kim JH, Yoo YJ. Augmented expression of peroxiredoxin I in lung cancer. Biochemical and Biophysical Research Communications. 289: 507-12. PMID 11716502 DOI: 10.1006/bbrc.2001.5989  0.32
2001 Lee Y, Jeon HB, Huang H, Sayre LM. Temporary inactivation of plasma amine oxidase by alkylhydrazines. A combined enzyme/model study implicates cofactor reduction/reoxidation but cofactor deoxygenation and subsequent reoxygenation in the case of hydrazine itself. The Journal of Organic Chemistry. 66: 1925-37. PMID 11300883 DOI: 10.1021/jo001115o  1
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