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William D. Shipe, Ph.D. - Publications

Affiliations: 
2004 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
complex chemical synthesis
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9 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Forster AB, Abeywickrema P, Bunda J, Cox CD, Cabalu TD, Egbertson M, Fay J, Getty K, Hall D, Kornienko M, Lu J, Parthasarathy G, Reid J, Sharma S, Shipe WD, et al. The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design. Bioorganic & Medicinal Chemistry Letters. PMID 29113762 DOI: 10.1016/J.Bmcl.2017.10.054  0.342
2015 Raheem IT, Schreier JD, Fuerst J, Gantert L, Hostetler ED, Huszar S, Joshi A, Kandebo M, Kim SH, Li J, Ma B, McGaughey G, Sharma S, Shipe WD, Uslaner J, et al. Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorganic & Medicinal Chemistry Letters. PMID 26602277 DOI: 10.1016/J.Bmcl.2015.11.013  0.31
2015 Shipe WD, Sharik SS, Barrow JC, McGaughey GB, Theberge CR, Uslaner JM, Yan Y, Renger JJ, Smith SM, Coleman PJ, Cox CD. Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis. Journal of Medicinal Chemistry. PMID 26378882 DOI: 10.1021/Acs.Jmedchem.5B00983  0.36
2010 Yang FV, Shipe WD, Bunda JL, Nolt MB, Wisnoski DD, Zhao Z, Barrow JC, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Hartman GD, Lindsley CW. Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 20: 531-6. PMID 20004574 DOI: 10.1016/J.Bmcl.2009.11.100  0.328
2008 Yang ZQ, Barrow JC, Shipe WD, Schlegel KA, Shu Y, Yang FV, Lindsley CW, Rittle KE, Bock MG, Hartman GD, Uebele VN, Nuss CE, Fox SV, Kraus RL, Doran SM, et al. Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels. Journal of Medicinal Chemistry. 51: 6471-7. PMID 18817368 DOI: 10.1021/Jm800830N  0.328
2007 Shipe WD, Yang F, Zhao Z, Wolkenberg SE, Nolt MB, Lindsley CW. Convenient and General Microwave-Assisted Protocols for the Expedient Synthesis of Heterocycles Cheminform. 38. DOI: 10.3987/Rev-06-Sr(W)1  0.337
2006 Sorensen E, Shipe W. Syntheses of Guanacastepene E Synfacts. 2006: 1197-1197. DOI: 10.1055/s-2006-955593  0.361
2005 Shipe WD, Wolkenberg SE, Lindsley CW. Accelerating lead development by microwave-enhanced medicinal chemistry. Drug Discovery Today. Technologies. 2: 155-61. PMID 24981843 DOI: 10.1016/J.Ddtec.2005.05.002  0.325
2002 Shipe WD, Sorensen EJ. A Convergent Synthesis of the Tricyclic Architecture of the Guanacastepenes Featuring a Selective Ring Fragmentation Organic Letters. 4: 2063-2066. PMID 12049518 DOI: 10.1021/Ol0259342  0.426
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