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David Y. Huang - Related publications

University of North Carolina, Chapel Hill, Chapel Hill, NC 
Stroke, Alzheimer's disease, neurodegeneration
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Das M, Devi KP. Dihydroactinidiolide regulates Nrf2/HO-1 expression and inhibits caspase-3/Bax pathway to protect SH-SY5Y human neuroblastoma cells from oxidative stress induced neuronal apoptosis. Neurotoxicology. PMID 33617922 DOI: 10.1016/j.neuro.2021.02.006   
2021 Jonathan MC, Adrián SH, Gonzalo A. Type II nuclear receptors with potential role in Alzheimer disease. Molecular Aspects of Medicine. 100940. PMID 33397589 DOI: 10.1016/j.mam.2020.100940   
2021 Wang H, Yue Y, Zhao H, Wu H, Jiang K, Li S, Zhao M, Lin F. Neuroprotective Effects of 2-Substituted 1, 3-Selenazole Amide Derivatives on Amyloid-Beta-Induced Toxicity in a Transgenic Caenorhabditis Elegans Model of Alzheimer's Disease. Neurotoxicity Research. PMID 33400180 DOI: 10.1007/s12640-020-00321-x   
2021 Wang YY, Huang ZT, Yuan MH, Jing F, Cai RL, Zou Q, Pu YS, Wang SY, Chen F, Yi WM, Zhang HJ, Cai ZY. Role of Hypoxia Inducible Factor-1α in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 33612545 DOI: 10.3233/JAD-201448   
2021 Ali M, Saleem U, Anwar F, Imran M, Nadeem H, Ahmad B, Ali T, Atta-Ur-Rehman, Ismail T. Screening of Synthetic Isoxazolone Derivative Role in Alzheimer's Disease: Computational and Pharmacological Approach. Neurochemical Research. PMID 33486698 DOI: 10.1007/s11064-021-03229-w   
2021 Yi S, Chen S, Xiang J, Tan J, Huang K, Zhang H, Wang Y, Wu H. Genistein exerts a cell-protective effect via Nrf2/HO-1/PI3K signaling in Aβ25-35-induced Alzheimer's disease models in vitro. Folia Histochemica Et Cytobiologica. PMID 33605427 DOI: 10.5603/FHC.a2021.0006   
2021 Pal D, Mukherjee S, Song IH, Nimse SB. GSK-3 Inhibitors: A new class of drugs for Alzheimer's Disease Treatment. Current Drug Targets. PMID 33459229 DOI: 10.2174/1389450122666210114095307   
2021 Alausa A, Ogundepo S, Olaleke B, Adeyemi R, Olatinwo M, Ismail A. Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies. Chinese Medicine. 16: 1. PMID 33407732 DOI: 10.1186/s13020-020-00418-7   
2021 He P, Schulz P, Sierks MR. A conformation specific antibody against Oligomeric β-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease. The Journal of Biological Chemistry. 100241. PMID 33428939 DOI: 10.1074/jbc.RA120.015327   
2021 Xie QQ, Feng X, Huang YΥ, Fang N, Yi H, Wang ZJ, Cao QΥ, Lou GF, Pan JP, Hu Y, Li FC, Zheng Q, Xiao F. Nogo‑66 promotes β‑amyloid protein secretion via NgR/ROCK‑dependent BACE1 activation. Molecular Medicine Reports. 23. PMID 33495810 DOI: 10.3892/mmr.2021.11827   
2021 Robinson M, Lou J, Mehrazma B, Rauk A, Beazely M, Leonenko Z. Pseudopeptide Amyloid Aggregation Inhibitors: In Silico, Single Molecule and Cell Viability Studies. International Journal of Molecular Sciences. 22. PMID 33494369 DOI: 10.3390/ijms22031051   
2021 Franco ML, García-Carpio I, Comaposada-Baró R, Escribano-Saiz JJ, Chávez-Gutiérrez L, Vilar M. TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition. Life Science Alliance. 4. PMID 33536237 DOI: 10.26508/lsa.202000844   
2021 Owens LV, Benedetto A, Dawson N, Gaffney CJ, Parkin ET. Gene therapy-mediated enhancement of protective protein expression for the treatment of Alzheimer's disease. Brain Research. 147264. PMID 33422539 DOI: 10.1016/j.brainres.2020.147264   
2021 Duan W, Zou J, Chen X, Xiao C, Jiang W. Biglycan Expression Promotes β-Amyloid-Induced Microglial Activation via TLR2 in Mouse Cell Culture Model. Clinical Laboratory. 67. PMID 33491410 DOI: 10.7754/Clin.Lab.2020.200252   
2021 Hashimoto Y, Kusakari S, Nawa M, Okamoto K, Toyama Y, Matsuoka M. Restoration of the reduced CLSP activity alleviates memory impairment in Alzheimer disease. Translational Psychiatry. 11: 44. PMID 33441550 DOI: 10.1038/s41398-020-01168-8   
2021 Akhter R, Shao Y, Formica S, Khrestian M, Bekris LM. TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ in HMC3 cells. Molecular Immunology. PMID 33461764 DOI: 10.1016/j.molimm.2020.12.035   
2021 Wang P, Ye Y. Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex. Nature Communications. 12: 95. PMID 33398028 DOI: 10.1038/s41467-020-20322-w   
2021 Suresh P, Phasuk S, Liu IY. Modulation of microglia activation and Alzheimer's disease: CX3 chemokine ligand 1/CX3CR and P2XR signaling. Tzu Chi Medical Journal. 33: 1-6. PMID 33505871 DOI: 10.4103/tcmj.tcmj_144_20   
2021 Di J, Siddique I, Li Z, Malki G, Hornung S, Dutta S, Hurst I, Ishaaya E, Wang A, Tu S, Boghos A, Ericsson I, Klärner FG, Schrader T, Bitan G. The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice. Alzheimer's Research & Therapy. 13: 6. PMID 33397489 DOI: 10.1186/s13195-020-00743-x   
2021 Kabir MT, Uddin MS, Zaman S, Rahman MS, Behl T, Ahmad A, Hafeez A, Perveen A, Ashraf GM. Exploring the Anti-Neuroinflammatory Potential of Steroid and Terpenoid-Derived Phytochemicals to Combat Alzheimer's Disease. Current Pharmaceutical Design. PMID 33463452 DOI: 10.2174/1381612826666210101152352   
2021 Park G, Moon BC, Ryu SM, Kim WJ, Lim HS. Cicadidae Periostracum Attenuates Atopic Dermatitis Symptoms and Pathology via the Regulation of NLRP3 Inflammasome Activation. Oxidative Medicine and Cellular Longevity. 2021: 8878153. PMID 33520088 DOI: 10.1155/2021/8878153   
2021 Lim KH, Kim SH, Yang S, Chun S, Joo JY. Advances in multiplex PCR for Alzheimer's disease diagnostics targeting CDK genes. Neuroscience Letters. 135715. PMID 33600906 DOI: 10.1016/j.neulet.2021.135715   
2021 Ding Q, Shults NV, Gychka SG, Harris BT, Suzuki YJ. Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains with Alzheimer's Disease. International Journal of Molecular Sciences. 22. PMID 33567524 DOI: 10.3390/ijms22041687   
2021 Patrick E, Olah M, Taga M, Klein HU, Xu J, White CC, Felsky D, Agrawal S, Gaiteri C, Chibnik LB, Mostafavi S, Schneider JA, Bennett DA, Bradshaw EM, De Jager PL. A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies. Translational Psychiatry. 11: 50. PMID 33446646 DOI: 10.1038/s41398-020-01175-9   
2021 Fonar G, Polis B, Sams DS, Levi A, Malka A, Bal N, Maltsev A, Elliott E, Samson AO. Modified Snake α-Neurotoxin Averts β-Amyloid Binding to α7 Nicotinic Acetylcholine Receptor and Reverses Cognitive Deficits in Alzheimer's Disease Mice. Molecular Neurobiology. PMID 33417228 DOI: 10.1007/s12035-020-02270-0   
2021 Liu M, Beckett T, Am Thomason L, Dorr A, Stefanovic B, McLaurin J. Covert strokes prior to Alzheimer's disease onset accelerate peri-lesional pathology but not cognitive deficits in an inducible APP mouse model. Brain Research. 147233. PMID 33412147 DOI: 10.1016/j.brainres.2020.147233   
2021 Sharma VK, Singh TG. CREB: A Multifaceted Target for Alzheimer's Disease. Current Alzheimer Research. PMID 33602089 DOI: 10.2174/1567205018666210218152253   
2021 Lee SB, Park A, Ma CT, Kim YH, Yang HO. 3'-O-Acetyl-24-Epi-7,8-Didehydrocimigenol-3-O-β-D-Xylopryranoside Decreases Amyloid Beta Production in Amyloid Precursor Protein-Transfected HeLa Cells. Biomolecules & Therapeutics. PMID 33619237 DOI: 10.4062/biomolther.2020.195   
2021 Patnaik D, Pao PC, Zhao WN, Silva MC, Hylton NK, Chindavong PS, Pan L, Tsai LH, Haggarty SJ. Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration. Acs Chemical Neuroscience. PMID 33417763 DOI: 10.1021/acschemneuro.0c00308   
2021 Chiang MC, Nicol CJB, Lin CH, Chen SJ, Yen C, Huang RN. Nanogold induces anti-inflammation against oxidative stress induced in human neural stem cells exposed to Amyloid-beta peptide. Neurochemistry International. 104992. PMID 33609598 DOI: 10.1016/j.neuint.2021.104992   
2021 Turkez H, Cacciatore I, Marinelli L, Fornasari E, Aslan ME, Cadirci K, Kahraman CY, Caglar O, Tatar A, Di Biase G, Hacimuftuoglu A, Di Stefano A, Mardinoglu A. Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer's Disease. Biomolecules. 11. PMID 33478054 DOI: 10.3390/biom11010126   
2021 Chakraborty S, Rakshit J, Bandyopadhyay J, Basu S. Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: Implication in Alzheimer's disease therapeutics. International Journal of Biological Macromolecules. PMID 33581209 DOI: 10.1016/j.ijbiomac.2021.02.073   
2021 Choi YB, Dunn-Meynell AA, Marchese M, Blumberg BM, Gaindh D, Dowling PC, Lu W. Erythropoietin-derived peptide treatment reduced neurological deficit and neuropathological changes in a mouse model of tauopathy. Alzheimer's Research & Therapy. 13: 32. PMID 33504364 DOI: 10.1186/s13195-020-00766-4   
2021 Xu Y, Chen S, Chen J. Profiling transcriptomic changes and signaling pathways in atopic dermatitis by integrative analyses on multiple databases. Molecular Genetics and Genomics : Mgg. PMID 33438050 DOI: 10.1007/s00438-020-01754-x   
2021 Schrott L, Yi P, Jackson K, Jackson GS, Webb C, Minagar A, Yun WJ, Purdum G, Rios DJ, Tyler TA, Vizcanio MI, Castor JL, Castor T, Alexander JS. Nanoparticle-Encapsulated Bryostatin-1 Activates α-Secretase and PKC Isoforms In vitro and Facilitates Acquisition and Retention of Spatial Learning in an Alzheimer's Disease Mouse Model. Current Alzheimer Research. PMID 33602091 DOI: 10.2174/1567205018666210218155835   
2021 Remya C, Dileep KV, Variyar EJ, Zhang KYJ, Omkumar RV, Sadasivan C. Chemical similarity assisted search for acetylcholinesterase inhibitors: Molecular modeling and evaluation of their neuroprotective properties. International Journal of Biological Macromolecules. PMID 33497692 DOI: 10.1016/j.ijbiomac.2021.01.148   
2021 Campora M, Canale C, Gatta E, Tasso B, Laurini E, Relini A, Pricl S, Catto M, Tonelli M. Multitarget Biological Profiling of New Naphthoquinone and Anthraquinone-Based Derivatives for the Treatment of Alzheimer's Disease. Acs Chemical Neuroscience. PMID 33428389 DOI: 10.1021/acschemneuro.0c00624   
2021 Park J, Choi H, Kim YD, Kim SH, Kim Y, Gwon Y, Lee DY, Park SH, Heo WD, Jung YK. Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation. Molecular Psychiatry. PMID 33452442 DOI: 10.1038/s41380-020-01003-y   
2021 Syeda T, Cannon JR. Environmental exposures and the etiopathogenesis of Alzheimer's disease: The potential role of BACE1 as a critical neurotoxic target. Journal of Biochemical and Molecular Toxicology. e22694. PMID 33393683 DOI: 10.1002/jbt.22694   
2021 Setti SE, Raymick J, Hanig J, Sarkar S. In vivo demonstration of Congo Red labeled amyloid plaques via perfusion in the Alzheimer disease rat model. Journal of Neuroscience Methods. 109082. PMID 33508413 DOI: 10.1016/j.jneumeth.2021.109082   
2021 Hellerhoff I, King JA, Tam FI, Pauligk S, Seidel M, Geisler D, Bahnsen K, Kretschmann N, Akgün K, Roessner V, Ziemssen T, Ehrlich S. Differential longitudinal changes of neuronal and glial damage markers in anorexia nervosa after partial weight restoration. Translational Psychiatry. 11: 86. PMID 33558486 DOI: 10.1038/s41398-021-01209-w   
2021 Wani A, Al Rihani SB, Sharma A, Weadick B, Govindarajan R, Khan SU, Sharma PR, Dogra A, Nandi U, Reddy CN, Bharate SS, Singh G, Bharate SB, Vishwakarma RA, Kaddoumi A, et al. Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway. Autophagy. PMID 33404280 DOI: 10.1080/15548627.2021.1872187   
2021 Li B, Xie PJ, Hao YW, Guo Y, Yu JR, Gong DY, Guo J, Zeng JH, Zhang Y. Yuan‑zhi‑san inhibits tau protein aggregation in an Aβ‑induced Alzheimer's disease rat model via the ubiquitin‑proteasome system. Molecular Medicine Reports. 23. PMID 33604685 DOI: 10.3892/mmr.2021.11918   
2021 Schmidt MF, Gan ZY, Komander D, Dewson G. Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities. Cell Death and Differentiation. PMID 33414510 DOI: 10.1038/s41418-020-00706-7   
2021 Kushwaha P, Singh V, Somvanshi P, Bhardwaj T, Barreto GE, Ashraf GM, Mishra BN, Chundawat RS, Haque S. Identification of new BACE1 inhibitors for treating Alzheimer's disease. Journal of Molecular Modeling. 27: 58. PMID 33517514 DOI: 10.1007/s00894-021-04679-3   
2021 Liu L, Cao J, Huang C, Yuan E, Ren J. Analysis the alteration of systemic inflammation in old and young APP/PS1 mouse. Experimental Gerontology. 111274. PMID 33561502 DOI: 10.1016/j.exger.2021.111274   
2021 Lee ZF, Huang TH, Chen SP, Cheng IH. Altered nociception in Alzheimer's disease is associated with STEP signaling. Pain. PMID 33433143 DOI: 10.1097/j.pain.0000000000002180   
2021 Gomes GN, Levine ZA. Defining the Neuropathological Aggresome across , , and Experiments. The Journal of Physical Chemistry. B. PMID 33464098 DOI: 10.1021/acs.jpcb.0c09193   
2021 Perez FP, Maloney B, Chopra N, Morisaki JJ, Lahiri DK. Repeated electromagnetic field stimulation lowers amyloid-β peptide levels in primary human mixed brain tissue cultures. Scientific Reports. 11: 621. PMID 33436686 DOI: 10.1038/s41598-020-77808-2   
2021 Bartling CRO, Jensen TMT, Henry SM, Colliander AL, Sereikaite V, Wenzler M, Jain P, Maric HM, Harpsøe K, Pedersen SW, Clemmensen LS, Haugaard-Kedström LM, Gloriam DE, Ho A, Strømgaard K. Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation. Journal of the American Chemical Society. PMID 33398998 DOI: 10.1021/jacs.0c10696