Paul J. Lucassen - Publications

SILS-CNS University of Amsterdam, Amsterdam, Netherlands 
Neurogenesis, stress, depression, Alzheimer

169 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Zhang L, Verwer RWH, van Heerikhuize J, Lucassen PJ, Nathanielsz PW, Hol EM, Aronica E, Dhillo WS, Meynen G, Swaab DF. Progesterone receptor distribution in the human hypothalamus and its association with suicide. Acta Neuropathologica Communications. 12: 16. PMID 38263257 DOI: 10.1186/s40478-024-01733-y  0.719
2022 Kaiser A, Reneman L, Solleveld MM, Coolen BF, Scherder EJA, Knutsson L, Bjørnerud A, van Osch MJP, Wijnen JP, Lucassen PJ, Schrantee A. A Randomized Controlled Trial on the Effects of a 12-Week High- vs. Low-Intensity Exercise Intervention on Hippocampal Structure and Function in Healthy, Young Adults. Frontiers in Psychiatry. 12: 780095. PMID 35126199 DOI: 10.3389/fpsyt.2021.780095  0.763
2021 Zhang L, Lucassen PJ, Salta E, Verhaert PDEM, Swaab DF. Hippocampal neuropathology in suicide: Gaps in our knowledge and opportunities for a breakthrough. Neuroscience and Biobehavioral Reviews. 132: 542-552. PMID 34906612 DOI: 10.1016/j.neubiorev.2021.12.023  0.337
2021 Zhang L, Verwer RWH, Zhao J, Huitinga I, Lucassen PJ, Swaab DF. Changes in glial gene expression in the prefrontal cortex in relation to major depressive disorder, suicide and psychotic features. Journal of Affective Disorders. 295: 893-903. PMID 34706460 DOI: 10.1016/j.jad.2021.08.098  0.387
2021 Kaiser A, Reneman L, Lucassen PJ, de Vries TJ, Schrantee A, Kaag AM. Targeting working memory to modify emotional reactivity in adult attention deficit hyperactivity disorder: a functional magnetic resonance imaging study. Brain Imaging and Behavior. PMID 34524649 DOI: 10.1007/s11682-021-00532-6  0.762
2021 Homberg JR, Adan RAH, Alenina N, Asiminas A, Bader M, Beckers T, Begg DP, Blokland A, Burger ME, van Dijk G, Eisel ULM, Elgersma Y, Englitz B, Fernandez-Ruiz A, Fitzsimons CP, ... ... Lucassen PJ, et al. The continued need for animals to advance brain research. Neuron. 109: 2374-2379. PMID 34352213 DOI: 10.1016/j.neuron.2021.07.015  0.418
2021 Swaab DF, Buijs RM, Kreier F, Lucassen PJ, Salehi A. Preface. Handbook of Clinical Neurology. 182: ix-xi. PMID 34266616 DOI: 10.1016/B978-0-12-819973-2.09997-4  0.464
2021 Swaab DF, Buijs RM, Kreier F, Lucassen PJ, Salehi A. Introduction: The human hypothalamus and neuropsychiatric disorders. Handbook of Clinical Neurology. 182: 1-5. PMID 34266586 DOI: 10.1016/B978-0-12-819973-2.00001-0  0.519
2021 Swaab DF, Buijs RM, Lucassen PJ, Salehi A, Kreier F. Introduction: The human hypothalamus and neuroendocrine disorders. Handbook of Clinical Neurology. 181: 1-5. PMID 34238450 DOI: 10.1016/B978-0-12-820683-6.00001-4  0.52
2021 Swaab DF, Kreier F, Lucassen PJ, Salehi A, Buijs RM. Preface. Handbook of Clinical Neurology. 179: ix-xi. PMID 34225988 DOI: 10.1016/B978-0-12-819975-6.09987-8  0.464
2021 Swaab DF, Buijs RM, Kreier F, Lucassen PJ, Salehi A. Introduction: The anterior hypothalamus. Handbook of Clinical Neurology. 179: 3-5. PMID 34225970 DOI: 10.1016/B978-0-12-819975-6.00014-5  0.5
2021 Swaab DF, Kreier F, Lucassen PJ, Salehi A, Buijs RM. Introduction: The middle and posterior hypothalamus. Handbook of Clinical Neurology. 180: 1-4. PMID 34225923 DOI: 10.1016/B978-0-12-820107-7.00001-X  0.502
2020 Hu P, Maita I, Phan ML, Gu E, Kwok C, Dieterich A, Gergues MM, Yohn CN, Wang Y, Zhou JN, Qi XR, Swaab DF, Pang ZP, Lucassen PJ, Roepke TA, et al. Early-life stress alters affective behaviors in adult mice through persistent activation of CRH-BDNF signaling in the oval bed nucleus of the stria terminalis. Translational Psychiatry. 10: 396. PMID 33177511 DOI: 10.1038/s41398-020-01070-3  0.628
2020 Genzel L, Adan R, Berns A, van den Beucken JJJP, Blokland A, Boddeke EHWGM, Bogers WM, Bontrop R, Bulthuis R, Bousema T, Clevers H, Coenen TCJJ, van Dam AM, Deen PMT, van Dijk KW, ... ... Lucassen PJ, et al. How the COVID-19 pandemic highlights the necessity of animal research. Current Biology : Cb. 30: 4328. PMID 33142090 DOI: 10.1016/j.cub.2020.10.033  0.631
2020 Genzel L, Adan R, Berns A, van den Beucken J, Blokland A, Boddeke EHWGM, Bogers WM, Bontrop R, Bulthuis R, Bousema T, Clevers H, Coenen TCJJ, Dam AV, Deen PMT, van Dijk KW, ... ... Lucassen PJ, et al. How the COVID-19 pandemic highlights the necessity of animal research. Current Biology : Cb. 30: R1014-R1018. PMID 32961149 DOI: 10.1016/J.Cub.2020.08.030  0.67
2020 D'Alessio L, Mesarosova L, Anink JJ, Kochen S, Solís P, Oddo S, Konopka H, Iyer AM, Mühlebner A, Lucassen PJ, Aronica E, van Vliet EA. Reduced expression of the glucocorticoid receptor in the hippocampus of patients with drug-resistant temporal lobe epilepsy and comorbid depression. Epilepsia. PMID 32652588 DOI: 10.1111/Epi.16598  0.305
2020 Solleveld MM, Schrantee A, Homberg JR, Lucassen PJ, Reneman L. The influence of age-of-onset of antidepressant use on the acute CBF response to a citalopram challenge; a pharmacological MRI study. Psychiatry Research. Neuroimaging. 303: 111126. PMID 32592855 DOI: 10.1016/J.Pscychresns.2020.111126  0.579
2020 Zhang L, Verwer RWH, Lucassen PJ, Huitinga I, Swaab DF. Sex difference in glia gene expression in the dorsolateral prefrontal cortex in bipolar disorder: Relation to psychotic features. Journal of Psychiatric Research. 125: 66-74. PMID 32208195 DOI: 10.1016/J.Jpsychires.2020.03.003  0.439
2020 Solleveld MM, Schrantee A, Baek HK, Bottelier MA, Tamminga HGH, Bouziane C, Stoffelsen R, Lucassen PJ, Van Someren EJW, Rijsman RM, Reneman L. Effects of 16 Weeks of Methylphenidate Treatment on Actigraph-Assessed Sleep Measures in Medication-Naive Children With ADHD. Frontiers in Psychiatry. 11: 82. PMID 32184743 DOI: 10.3389/Fpsyt.2020.00082  0.53
2020 Hu P, van Dam AM, Wang Y, Lucassen PJ, Zhou JN. Retinoic Acid and Depressive Disorders: Evidence and Possible Neurobiological Mechanisms. Neuroscience and Biobehavioral Reviews. PMID 32070693 DOI: 10.1016/J.Neubiorev.2020.02.013  0.569
2020 Hu P, Liu J, Maita I, Kwok C, Gu E, Gergues MM, Kelada F, Phan M, Zhou JN, Swaab DF, Pang Z, Lucassen PJ, Roepke TA, Samuels BA. Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32054675 DOI: 10.1523/Jneurosci.2410-19.2020  0.637
2020 Kaiser A, Reneman L, Lucassen P, Kaag A, Van der Zwaag W, Jurhar T, Kirschbaum C, Van den Heuvel O, Hermans E, Tan H. P.192 The association between stress-induced changes in prefrontal GABA levels and heart rate variability: a 7T 1H-MRS study European Neuropsychopharmacology. 40: S111-S112. DOI: 10.1016/j.euroneuro.2020.09.147  0.751
2020 Maletic-Savatic M, Li Y, Young D, Elvsåshagen T, Loo C, Reneman L, Lucassen PJ, Calarge C, Valenzuela M. Fatty Acids as Biomarkers of Neurogenesis and New Targets for Treatment of Depression Biological Psychiatry. 87: S59. DOI: 10.1016/J.Biopsych.2020.02.174  0.534
2019 Lucassen PJ, Fitzsimons CP, Salta E, Maletic-Savatic M. Adult neurogenesis, human after all (again): classic, optimized, and future approaches. Behavioural Brain Research. 112458. PMID 31899214 DOI: 10.1016/J.Bbr.2019.112458  0.347
2019 Zhang L, Verwer RWH, Lucassen PJ, Huitinga I, Swaab DF. Prefrontal cortex alterations in glia gene expression in schizophrenia with and without suicide. Journal of Psychiatric Research. 121: 31-38. PMID 31739114 DOI: 10.1016/J.Jpsychires.2019.11.002  0.415
2019 Lesuis SL, Lucassen PJ, Krugers HJ. Early life stress amplifies fear responses and hippocampal synaptic potentiation in the APPswe/PS1dE9 Alzheimer mouse model. Neuroscience. PMID 31302265 DOI: 10.1016/J.Neuroscience.2019.07.012  0.314
2019 Zhao J, Lucassen PJ, Swaab DF. Suicide Is a Confounder in Postmortem Studies on Depression. Biological Psychiatry. PMID 31227102 DOI: 10.1016/J.Biopsych.2019.04.015  0.425
2019 Schouten M, Bielefeld P, Garcia-Corzo L, Passchier EMJ, Gradari S, Jungenitz T, Pons-Espinal M, Gebara E, Martín-Suárez S, Lucassen PJ, De Vries HE, Trejo JL, Schwarzacher SW, De Pietri Tonelli D, Toni N, et al. Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain. Molecular Psychiatry. PMID 31222184 DOI: 10.1038/S41380-019-0440-2  0.327
2019 Bielefeld P, Durá I, Danielewicz J, Lucassen PJ, Baekelandt V, Abrous DN, Encinas JM, Fitzsimons CP. Insult-induced aberrant hippocampal neurogenesis: Functional consequences and possible therapeutic strategies. Behavioural Brain Research. 372: 112032. PMID 31199935 DOI: 10.1016/J.Bbr.2019.112032  0.348
2019 Schrantee A, Solleveld MM, Schwantje H, Bruin WB, Mutsaerts HM, Adriaanse SM, Lucassen P, Booij J, Reneman L. Dose-dependent effects of the selective serotonin reuptake inhibitor citalopram: A combined SPECT and phMRI study. Journal of Psychopharmacology (Oxford, England). 269881119836229. PMID 30887865 DOI: 10.1177/0269881119836229  0.514
2019 Lesuis SL, Kaplick P, Lucassen PJ, Krugers HJ. Treatment with the glutamate modulator riluzole prevents early life stress-induced cognitive deficits and impairments in synaptic plasticity in APPswe/PS1dE9 mice. Neuropharmacology. PMID 30794835 DOI: 10.1016/J.Neuropharm.2019.02.023  0.335
2019 Lucassen PJ, Toni N, Kempermann G, Frisen J, Gage FH, Swaab DF. Limits to human neurogenesis-really? Molecular Psychiatry. PMID 30617274 DOI: 10.1038/S41380-018-0337-5  0.426
2019 Kaiser A, Reneman L, Lucassen P, De Vries T, Kaag A, Schrantee A. P.3.07 Targeting emotional dysregulation in adult attention-deficit hyperactivity disorder European Neuropsychopharmacology. 29: S683-S684. DOI: 10.1016/J.Euroneuro.2019.01.069  0.755
2018 Gao S, Zhang T, Jin L, Liang D, Fan G, Song Y, Lucassen PJ, Yu R, Swaab DF. CAPON Is a Critical Protein in Synaptic Molecular Networks in the Prefrontal Cortex of Mood Disorder Patients and Contributes to Depression-Like Behavior in a Mouse Model. Cerebral Cortex (New York, N.Y. : 1991). PMID 30307500 DOI: 10.1093/Cercor/Bhy254  0.479
2018 Lesuis SL, Hoeijmakers L, Korosi A, de Rooij SR, Swaab DF, Kessels HW, Lucassen PJ, Krugers HJ. Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve. Alzheimer's Research & Therapy. 10: 95. PMID 30227888 DOI: 10.1186/S13195-018-0422-7  0.472
2018 Schrantee A, Lucassen PJ, Booij J, Reneman L. Serotonin transporter occupancy by the SSRI citalopram predicts default-mode network connectivity. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 30082141 DOI: 10.1016/J.Euroneuro.2018.07.099  0.548
2018 Hoeijmakers L, Lesuis SL, Krugers H, Lucassen PJ, Korosi A. A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress. Neurobiology of Stress. 8: 172-185. PMID 29888312 DOI: 10.1016/J.Ynstr.2018.02.003  0.34
2018 Zhao J, Verwer RWH, Gao SF, Qi XR, Lucassen PJ, Kessels HW, Swaab DF. Prefrontal alterations in GABAergic and glutamatergic gene expression in relation to depression and suicide. Journal of Psychiatric Research. 102: 261-274. PMID 29753198 DOI: 10.1016/J.Jpsychires.2018.04.020  0.462
2018 Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, ... ... Lucassen PJ, et al. Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell. PMID 29681514 DOI: 10.1016/J.Stem.2018.04.004  0.322
2018 Hoeijmakers L, Amelianchik A, Verhaag F, Kotah J, Lucassen PJ, Korosi A. Early-Life Stress Does Not Aggravate Spatial Memory or the Process of Hippocampal Neurogenesis in Adult and Middle-Aged APP/PS1 Mice. Frontiers in Aging Neuroscience. 10: 61. PMID 29563870 DOI: 10.3389/Fnagi.2018.00061  0.319
2018 Lesuis SL, Weggen S, Baches S, Lucassen PJ, Krugers HJ. Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice. Translational Psychiatry. 8: 53. PMID 29491368 DOI: 10.1038/S41398-018-0101-2  0.331
2018 van Campen JS, Hessel EVS, Bohmbach K, Rizzi G, Lucassen PJ, Lakshmi Turimella S, Umeoka EHL, Meerhoff GF, Braun KPJ, de Graan PNE, Joëls M. Stress and Corticosteroids Aggravate Morphological Changes in the Dentate Gyrus after Early-Life Experimental Febrile Seizures in Mice. Frontiers in Endocrinology. 9: 3. PMID 29434572 DOI: 10.3389/Fendo.2018.00003  0.301
2018 Schrantee A, Wijnen JP, Solleveld MM, Nederveen AJ, Dumoulin S, Klomp DW, Reneman L, Lucassen PJ. F153. The Effect of a 12-Week Aerobic Exercise Intervention on Neurometabolites in Young Healthy Adults Using 7T Magnetic Resonance Spectroscopy Biological Psychiatry. 83: S297-S298. DOI: 10.1016/J.Biopsych.2018.02.767  0.525
2018 Schrantee A, Lucassen PJ, Reneman L, Booij J. T138. Serotonin Transporter Occupancy Predicts Default-Mode Network Connectivity: A SPECT and Resting-State fMRI Study Biological Psychiatry. 83: S182. DOI: 10.1016/J.Biopsych.2018.02.475  0.502
2017 Hoeijmakers L, Meerhoff GF, de Vries JW, Ruigrok SR, van Dam AM, van Leuven F, Korosi A, Lucassen PJ. The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis. Neurobiology of Aging. 61: 112-123. PMID 29059594 DOI: 10.1016/J.Neurobiolaging.2017.09.013  0.309
2017 Yam KY, Ruigrok SR, Ziko I, De Luca SN, Lucassen PJ, Spencer SJ, Korosi A. Ghrelin and hypothalamic NPY/AgRP expression in mice are affected by chronic early-life stress exposure in a sex-specific manner. Psychoneuroendocrinology. 86: 73-77. PMID 28917185 DOI: 10.1016/J.Psyneuen.2017.09.006  0.31
2017 Solleveld MM, Schrantee A, Puts NAJ, Reneman L, Lucassen PJ. Age-dependent, lasting effects of methylphenidate on the GABAergic system of ADHD patients. Neuroimage. Clinical. 15: 812-818. PMID 28725548 DOI: 10.1016/J.Nicl.2017.06.003  0.565
2017 Walker CD, Bath KG, Joels M, Korosi A, Larauche M, Lucassen PJ, Morris MJ, Raineki C, Roth TL, Sullivan RM, Taché Y, Baram TZ. Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential. Stress (Amsterdam, Netherlands). 1-63. PMID 28617197 DOI: 10.1080/10253890.2017.1343296  0.325
2017 Lesuis SL, van Hoek BACE, Lucassen PJ, Krugers HJ. Early postnatal handling reduces hippocampal amyloid plaque formation and enhances cognitive performance in APPswe/PS1dE9 mice at middle age. Neurobiology of Learning and Memory. 144: 27-35. PMID 28579367 DOI: 10.1016/J.Nlm.2017.05.016  0.317
2017 Abbink MR, Naninck EFG, Lucassen PJ, Korosi A. Early-life stress diminishes the increase in neurogenesis after exercise in adult female mice. Hippocampus. 27: 839-844. PMID 28558121 DOI: 10.1002/Hipo.22745  0.311
2017 Schrantee A, Tremoleda JL, Wylezinska-Arridge M, Bouet V, Hesseling P, Meerhoff GF, de Bruin KM, Koeleman J, Freret T, Boulouard M, Desfosses E, Galineau L, Gozzi A, Dauphin F, Gsell W, ... ... Lucassen PJ, et al. Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate. Plos One. 12: e0172776. PMID 28241065 DOI: 10.1371/Journal.Pone.0172776  0.561
2017 Krugers HJ, Arp JM, Xiong H, Kanatsou S, Lesuis SL, Korosi A, Joels M, Lucassen PJ. Early life adversity: Lasting consequences for emotional learning. Neurobiology of Stress. 6: 14-21. PMID 28229105 DOI: 10.1016/J.Ynstr.2016.11.005  0.313
2017 Solleveld M, Schrantee A, Baek H, Bottelier M, Lucassen P, Van Someren E, Rijsman R, Reneman L. Enduring effects of methylphenidate on sleep in children with attention-deficit/hyperactivity disorder: a double-blind randomized controlled trial European Neuropsychopharmacology. 27: S1111-S1112. DOI: 10.1016/S0924-977X(17)31927-2  0.526
2017 Kaiser A, Schrantee A, Solleveld M, Reneman L, Lucassen P. Effects of cardiovascular fitness on hippocampal volume and vasculature in young adults European Neuropsychopharmacology. 27: S720-S721. DOI: 10.1016/S0924-977X(17)31327-5  0.76
2017 Schrantee A, Lucassen P, Booij J, Reneman L. Non-invasive magnetic resonance imaging of human serotonin function: dose-dependent effects of citalopram European Neuropsychopharmacology. 27: S707-S708. DOI: 10.1016/S0924-977X(17)31308-1  0.521
2016 Hoeijmakers L, Ruigrok SR, Amelianchik A, Ivan D, Dam AV, Lucassen PJ, Korosi A. Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model. Brain, Behavior, and Immunity. PMID 28027926 DOI: 10.1016/J.Bbi.2016.12.023  0.32
2016 Reemst K, Noctor SC, Lucassen PJ, Hol EM. The Indispensable Roles of Microglia and Astrocytes during Brain Development. Frontiers in Human Neuroscience. 10: 566. PMID 27877121 DOI: 10.3389/Fnhum.2016.00566  0.549
2016 Naninck EF, Oosterink JE, Yam KY, de Vries LP, Schierbeek H, van Goudoever JB, Verkaik-Schakel RN, Plantinga JA, Plosch T, Lucassen PJ, Korosi A. Early micronutrient supplementation protects against early stress-induced cognitive impairments. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27770020 DOI: 10.1096/Fj.201600834R  0.306
2016 Hoeijmakers L, Heinen Y, van Dam AM, Lucassen PJ, Korosi A. Microglial Priming and Alzheimer's Disease: A Possible Role for (Early) Immune Challenges and Epigenetics? Frontiers in Human Neuroscience. 10: 398. PMID 27555812 DOI: 10.3389/Fnhum.2016.00398  0.321
2016 Schouten M, Bielefeld P, Fratantoni SA, Hubens CJ, Piersma SR, Pham TV, Voskuyl RA, Lucassen PJ, Jimenez CR, Fitzsimons CP. Multi-omics profile of the mouse dentate gyrus after kainic acid-induced status epilepticus. Scientific Data. 3: 160068. PMID 27529540 DOI: 10.1038/Sdata.2016.68  0.318
2016 Kandola A, Hendrikse J, Lucassen PJ, Yücel M. Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment. Frontiers in Human Neuroscience. 10: 373. PMID 27524962 DOI: 10.3389/Fnhum.2016.00373  0.318
2016 Schrantee A, Tamminga HG, Bouziane C, Bottelier MA, Bron EE, Mutsaerts HM, Zwinderman AH, Groote IR, Rombouts SA, Lindauer RJ, Klein S, Niessen WJ, Opmeer BC, Boer F, Lucassen PJ, et al. Age-Dependent Effects of Methylphenidate on the Human Dopaminergic System in Young vs Adult Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial. Jama Psychiatry. PMID 27487479 DOI: 10.1001/Jamapsychiatry.2016.1572  0.561
2016 Zhao J, Verwer RW, van Wamelen DJ, Qi XR, Gao SF, Lucassen PJ, Swaab DF. Prefrontal changes in the glutamate-glutamine cycle and neuronal/glial glutamate transporters in depression with and without suicide. Journal of Psychiatric Research. 82: 8-15. PMID 27450072 DOI: 10.1016/J.Jpsychires.2016.06.017  0.453
2016 Lesuis SL, Maurin H, Borghgraef P, Lucassen PJ, Van Leuven F, Krugers HJ. Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease. Oncotarget. PMID 27259247 DOI: 10.18632/Oncotarget.9776  0.322
2016 Fitzsimons CP, Herbert J, Schouten M, Meijer OC, Lucassen PJ, Lightman S. Circadian and Ultradian Glucocorticoid Rhythmicity: Implications for the Effects of Glucocorticoids on Neural Stem Cells and Adult Hippocampal Neurogenesis. Frontiers in Neuroendocrinology. PMID 27234350 DOI: 10.1016/J.Yfrne.2016.05.001  0.319
2016 Hu P, Wang Y, Liu J, Meng FT, Qi XR, Chen L, van Dam AM, Joëls M, Lucassen PJ, Zhou JN. Chronic retinoic acid treatment suppresses adult hippocampal neurogenesis, in close correlation with depressive-like behavior. Hippocampus. PMID 26860546 DOI: 10.1002/Hipo.22574  0.579
2016 Lucassen PJ, Oomen CA. Stress, hippocampal neurogenesis and cognition: functional correlations Frontiers in Biology. 11: 182-192. DOI: 10.1007/S11515-016-1412-4  0.362
2015 Herbert J, Lucassen PJ. Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines and neurogenesis - what do we need to know? Frontiers in Neuroendocrinology. PMID 26746105 DOI: 10.1016/J.Yfrne.2015.12.001  0.315
2015 Kanatsou S, Fearey BC, Kuil LE, Lucassen PJ, Harris AP, Seckl JR, Krugers H, Joels M. Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity. Plos One. 10: e0142012. PMID 26600250 DOI: 10.1371/Journal.Pone.0142012  0.321
2015 Lucassen PJ, Oomen CA, Naninck EF, Fitzsimons CP, van Dam AM, Czeh B, Korosi A. Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation. Cold Spring Harbor Perspectives in Biology. 7. PMID 26330520 DOI: 10.1101/Cshperspect.A021303  0.341
2015 Loi M, Mossink JC, Meerhoff GF, Den Blaauwen JL, Lucassen PJ, Joëls M. Effects of early-life stress on cognitive function and hippocampal structure in female rodents. Neuroscience. PMID 26297897 DOI: 10.1016/J.Neuroscience.2015.08.024  0.327
2015 Klomp A, Václavů L, Meerhoff GF, Reneman L, Lucassen PJ. Correction: Effects of Chronic Fluoxetine Treatment on Neurogenesis and Tryptophan Hydroxylase Expression in Adolescent and Adult Rats. Plos One. 10: e0135876. PMID 26295703 DOI: 10.1371/journal.pone.0135876  0.5
2015 van der Marel K, Bouet V, Meerhoff GF, Freret T, Boulouard M, Dauphin F, Klomp A, Lucassen PJ, Homberg JR, Dijkhuizen RM, Reneman L. Effects of long-term methylphenidate treatment in adolescent and adult rats on hippocampal shape, functional connectivity and adult neurogenesis. Neuroscience. PMID 25934041 DOI: 10.1016/J.Neuroscience.2015.04.044  0.594
2015 Schrantee A, Václav? L, Heijtel DF, Caan MW, Gsell W, Lucassen PJ, Nederveen AJ, Booij J, Reneman L. Dopaminergic system dysfunction in recreational dexamphetamine users. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1172-80. PMID 25394786 DOI: 10.1038/Npp.2014.301  0.546
2015 Naninck EF, Hoeijmakers L, Kakava-Georgiadou N, Meesters A, Lazic SE, Lucassen PJ, Korosi A. Chronic early life stress alters developmental and adult neurogenesis and impairs cognitive function in mice. Hippocampus. 25: 309-28. PMID 25269685 DOI: 10.1002/Hipo.22374  0.343
2014 Hoeijmakers L, Lucassen PJ, Korosi A. The interplay of early-life stress, nutrition, and immune activation programs adult hippocampal structure and function. Frontiers in Molecular Neuroscience. 7: 103. PMID 25620909 DOI: 10.3389/Fnmol.2014.00103  0.303
2014 Kuipers SD, Bramham CR, Cameron HA, Fitzsimons CP, Korosi A, Lucassen PJ. Environmental control of adult neurogenesis: from hippocampal homeostasis to behavior and disease. Neural Plasticity. 2014: 808643. PMID 25580306 DOI: 10.1155/2014/808643  0.331
2014 Marlatt MW, Bauer J, Aronica E, van Haastert ES, Hoozemans JJ, Joels M, Lucassen PJ. Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. Neural Plasticity. 2014: 693851. PMID 25215243 DOI: 10.1155/2014/693851  0.324
2014 Fitzsimons CP, van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, van den Hurk M, Boks MP, Biojone C, Joca S, Steinbusch HW, Lunnon K, Mastroeni DF, Mill J, Lucassen PJ, et al. Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease. Molecular Neurodegeneration. 9: 25. PMID 24964731 DOI: 10.1186/1750-1326-9-25  0.341
2014 Boekhoorn K, van Dis V, Goedknegt E, Sobel A, Lucassen PJ, Hoogenraad CC. The microtubule destabilizing protein stathmin controls the transition from dividing neuronal precursors to postmitotic neurons during adult hippocampal neurogenesis. Developmental Neurobiology. 74: 1226-42. PMID 24909416 DOI: 10.1002/Dneu.22200  0.343
2014 Klomp A, Václav? L, Meerhoff GF, Reneman L, Lucassen PJ. Effects of chronic fluoxetine treatment on neurogenesis and tryptophan hydroxylase expression in adolescent and adult rats. Plos One. 9: e97603. PMID 24827731 DOI: 10.1371/Journal.Pone.0097603  0.582
2014 Hoeijmakers L, Harbich D, Schmid B, Lucassen PJ, Wagner KV, Schmidt MV, Hartmann J. Depletion of FKBP51 in female mice shapes HPA axis activity. Plos One. 9: e95796. PMID 24759731 DOI: 10.1371/Journal.Pone.0095796  0.31
2014 Loi M, Koricka S, Lucassen PJ, Joëls M. Age- and sex-dependent effects of early life stress on hippocampal neurogenesis. Frontiers in Endocrinology. 5: 13. PMID 24600436 DOI: 10.3389/Fendo.2014.00013  0.343
2014 Lucassen PJ, Pruessner J, Sousa N, Almeida OF, Van Dam AM, Rajkowska G, Swaab DF, Czéh B. Neuropathology of stress. Acta Neuropathologica. 127: 109-35. PMID 24318124 DOI: 10.1007/S00401-013-1223-5  0.484
2014 van der Marel K, Klomp A, Meerhoff GF, Schipper P, Lucassen PJ, Homberg JR, Dijkhuizen RM, Reneman L. Long-term oral methylphenidate treatment in adolescent and adult rats: differential effects on brain morphology and function. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 263-73. PMID 23851400 DOI: 10.1038/Npp.2013.169  0.577
2014 Wang Q, Verweij EW, Krugers HJ, Joels M, Swaab DF, Lucassen PJ. Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients. Brain Structure & Function. 219: 1615-26. PMID 23748930 DOI: 10.1007/S00429-013-0589-4  0.505
2013 Lucassen PJ, Naninck EF, van Goudoever JB, Fitzsimons C, Joels M, Korosi A. Perinatal programming of adult hippocampal structure and function; emerging roles of stress, nutrition and epigenetics. Trends in Neurosciences. 36: 621-31. PMID 23998452 DOI: 10.1016/J.Tins.2013.08.002  0.326
2013 Marlatt MW, Potter MC, Bayer TA, van Praag H, Lucassen PJ. Prolonged running, not fluoxetine treatment, increases neurogenesis, but does not alter neuropathology, in the 3xTg mouse model of Alzheimer's disease. Current Topics in Behavioral Neurosciences. 15: 313-40. PMID 23670818 DOI: 10.1007/7854_2012_237  0.33
2013 Zalachoras I, Houtman R, Atucha E, Devos R, Tijssen AM, Hu P, Lockey PM, Datson NA, Belanoff JK, Lucassen PJ, Joëls M, de Kloet ER, Roozendaal B, Hunt H, Meijer OC. Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator. Proceedings of the National Academy of Sciences of the United States of America. 110: 7910-5. PMID 23613579 DOI: 10.1073/Pnas.1219411110  0.314
2013 Wang Q, Van Heerikhuize J, Aronica E, Kawata M, Seress L, Joels M, Swaab DF, Lucassen PJ. Glucocorticoid receptor protein expression in human hippocampus; stability with age. Neurobiology of Aging. 34: 1662-73. PMID 23290588 DOI: 10.1016/J.Neurobiolaging.2012.11.019  0.485
2013 Qi XR, Kamphuis W, Wang S, Wang Q, Lucassen PJ, Zhou JN, Swaab DF. Aberrant stress hormone receptor balance in the human prefrontal cortex and hypothalamic paraventricular nucleus of depressed patients. Psychoneuroendocrinology. 38: 863-70. PMID 23137715 DOI: 10.1016/J.Psyneuen.2012.09.014  0.643
2013 Fitzsimons CP, van Hooijdonk LW, Schouten M, Zalachoras I, Brinks V, Zheng T, Schouten TG, Saaltink DJ, Dijkmans T, Steindler DA, Verhaagen J, Verbeek FJ, Lucassen PJ, de Kloet ER, Meijer OC, et al. Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior. Molecular Psychiatry. 18: 993-1005. PMID 22925833 DOI: 10.1038/Mp.2012.123  0.35
2013 Lucassen PJ, Fitzsimons CP, Korosi A, Joels M, Belzung C, Abrous DN. Stressing new neurons into depression? Molecular Psychiatry. 18: 396-7. PMID 22547116 DOI: 10.1038/Mp.2012.39  0.338
2012 Hu P, Oomen C, van Dam AM, Wester J, Zhou JN, Joëls M, Lucassen PJ. A single-day treatment with mifepristone is sufficient to normalize chronic glucocorticoid induced suppression of hippocampal cell proliferation. Plos One. 7: e46224. PMID 23049985 DOI: 10.1371/Journal.Pone.0046224  0.556
2012 Claessens SE, Belanoff JK, Kanatsou S, Lucassen PJ, Champagne DL, de Kloet ER. Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: towards a rescue strategy. Brain Research. 1482: 1-12. PMID 22985498 DOI: 10.1016/J.Brainres.2012.08.017  0.319
2012 Saaltink DJ, HÃ¥vik B, Verissimo CS, Lucassen PJ, Vreugdenhil E. Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis. The Journal of Comparative Neurology. 520: 2805-23. PMID 22605579 DOI: 10.1002/Cne.23144  0.331
2012 Schouten M, Buijink MR, Lucassen PJ, Fitzsimons CP. New Neurons in Aging Brains: Molecular Control by Small Non-Coding RNAs. Frontiers in Neuroscience. 6: 25. PMID 22363255 DOI: 10.3389/Fnins.2012.00025  0.332
2012 Marlatt MW, Potter MC, Lucassen PJ, van Praag H. Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice. Developmental Neurobiology. 72: 943-52. PMID 22252978 DOI: 10.1002/Dneu.22009  0.307
2012 Wang Q, Joels M, Swaab DF, Lucassen PJ. Hippocampal GR expression is increased in elderly depressed females. Neuropharmacology. 62: 527-33. PMID 21945289 DOI: 10.1016/J.Neuropharm.2011.09.014  0.475
2012 Korosi A, Naninck EF, Oomen CA, Schouten M, Krugers H, Fitzsimons C, Lucassen PJ. Early-life stress mediated modulation of adult neurogenesis and behavior. Behavioural Brain Research. 227: 400-9. PMID 21821065 DOI: 10.1016/J.Bbr.2011.07.037  0.329
2012 Datson NA, Speksnijder N, Mayer JL, Steenbergen PJ, Korobko O, Goeman J, de Kloet ER, Joëls M, Lucassen PJ. The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus. Hippocampus. 22: 359-71. PMID 21184481 DOI: 10.1002/Hipo.20905  0.339
2011 Novati A, Hulshof HJ, Koolhaas JM, Lucassen PJ, Meerlo P. Chronic sleep restriction causes a decrease in hippocampal volume in adolescent rats, which is not explained by changes in glucocorticoid levels or neurogenesis. Neuroscience. 190: 145-55. PMID 21718758 DOI: 10.1016/J.Neuroscience.2011.06.027  0.315
2011 Marlatt MW, Philippens I, Manders E, Czéh B, Joels M, Krugers H, Lucassen PJ. Distinct structural plasticity in the hippocampus and amygdala of the middle-aged common marmoset (Callithrix jacchus). Experimental Neurology. 230: 291-301. PMID 21605555 DOI: 10.1016/J.Expneurol.2011.05.008  0.362
2011 Van Bokhoven P, Oomen CA, Hoogendijk WJ, Smit AB, Lucassen PJ, Spijker S. Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment. The European Journal of Neuroscience. 33: 1833-40. PMID 21488984 DOI: 10.1111/J.1460-9568.2011.07668.X  0.6
2011 Lemmens MA, Sierksma AS, Rutten BP, Dennissen F, Steinbusch HW, Lucassen PJ, Schmitz C. Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer's disease. Brain Structure & Function. 216: 227-37. PMID 21409417 DOI: 10.1007/S00429-011-0305-1  0.321
2011 Bruel-Jungerman E, Lucassen PJ, Francis F. Cholinergic influences on cortical development and adult neurogenesis. Behavioural Brain Research. 221: 379-88. PMID 21272598 DOI: 10.1016/J.Bbr.2011.01.021  0.323
2011 van Tijn P, Kamphuis W, Marlatt MW, Hol EM, Lucassen PJ. Presenilin mouse and zebrafish models for dementia: focus on neurogenesis. Progress in Neurobiology. 93: 149-64. PMID 21056616 DOI: 10.1016/J.Pneurobio.2010.10.008  0.541
2011 Oomen CA, Soeters H, Audureau N, Vermunt L, van Hasselt FN, Manders EM, Joëls M, Krugers H, Lucassen PJ. Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats. Psychopharmacology. 214: 249-60. PMID 20589492 DOI: 10.1007/S00213-010-1922-8  0.378
2010 Krugers HJ, Lucassen PJ, Karst H, Joëls M. Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by anti-glucocorticoid treatment. Frontiers in Synaptic Neuroscience. 2: 24. PMID 21423510 DOI: 10.3389/Fnsyn.2010.00024  0.329
2010 Oomen CA, Soeters H, Audureau N, Vermunt L, van Hasselt FN, Manders EM, Joëls M, Lucassen PJ, Krugers H. Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 6635-45. PMID 20463226 DOI: 10.1523/Jneurosci.0247-10.2010  0.331
2010 Lucassen PJ, Stumpel MW, Wang Q, Aronica E. Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients. Neuropharmacology. 58: 940-9. PMID 20138063 DOI: 10.1016/J.Neuropharm.2010.01.012  0.33
2010 Marlatt MW, Lucassen PJ. Neurogenesis and Alzheimer's disease: Biology and pathophysiology in mice and men. Current Alzheimer Research. 7: 113-25. PMID 19860727 DOI: 10.2174/156720510790691362  0.35
2010 Lucassen PJ, Meerlo P, Naylor AS, van Dam AM, Dayer AG, Fuchs E, Oomen CA, Czéh B. Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 20: 1-17. PMID 19748235 DOI: 10.1016/J.Euroneuro.2009.08.003  0.389
2009 Boer K, Lucassen PJ, Spliet WG, Vreugdenhil E, van Rijen PC, Troost D, Jansen FE, Aronica E. Doublecortin-like (DCL) expression in focal cortical dysplasia and cortical tubers. Epilepsia. 50: 2629-37. PMID 19583781 DOI: 10.1111/J.1528-1167.2009.02191.X  0.536
2009 Lucassen PJ, Scheper W, Van Someren EJ. Adult neurogenesis and the unfolded protein response; new cellular and molecular avenues in sleep research. Sleep Medicine Reviews. 13: 183-6. PMID 19345123 DOI: 10.1016/J.Smrv.2008.12.004  0.529
2009 Joëls M, Krugers HJ, Lucassen PJ, Karst H. Corticosteroid effects on cellular physiology of limbic cells. Brain Research. 1293: 91-100. PMID 19332034 DOI: 10.1016/J.Brainres.2009.03.036  0.34
2009 Oomen CA, Girardi CE, Cahyadi R, Verbeek EC, Krugers H, Joëls M, Lucassen PJ. Opposite effects of early maternal deprivation on neurogenesis in male versus female rats. Plos One. 4: e3675. PMID 19180242 DOI: 10.1371/Journal.Pone.0003675  0.36
2009 Joosen MJ, Jousma E, van den Boom TM, Kuijpers WC, Smit AB, Lucassen PJ, van Helden HP. Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning. Neurotoxicology. 30: 72-80. PMID 19100287 DOI: 10.1016/J.Neuro.2008.11.010  0.307
2009 Lucassen PJ, Bosch OJ, Jousma E, Krömer SA, Andrew R, Seckl JR, Neumann ID. Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11beta-hydroxysteroid dehydrogenase type 2. The European Journal of Neuroscience. 29: 97-103. PMID 19032587 DOI: 10.1111/J.1460-9568.2008.06543.X  0.31
2009 Marlatt MW, Hoozemans JJ, Veerhuis R, Lucassen PJ. Alzheimer’s disease and adult neurogenesis—Are endogenous stem cells part of the solution? Us Neurology. 5: 12-14. DOI: 10.17925/Usn.2009.05.01.12  0.371
2008 Marlatt MW, Lucassen PJ, Perry G, Smith MA, Zhu X. Alzheimer's disease: cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies. Journal of Alzheimer's Disease : Jad. 15: 199-210. PMID 18953109 DOI: 10.3233/Jad-2008-15206  0.3
2008 Thompson A, Boekhoorn K, Van Dam AM, Lucassen PJ. Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence? Genes, Brain, and Behavior. 7: 28-42. PMID 18184368 DOI: 10.1111/J.1601-183X.2007.00379.X  0.334
2008 Lucassen PJ, Oomen CA, Dam Av, Czéh B. 18 Regulation of Hippocampal Neurogenesis by Systemic Factors Including Stress, Glucocorticoids, Sleep, and Inflammation Cold Spring Harbor Monograph Archive. 52: 363-395. DOI: 10.1101/087969784.52.363  0.314
2008 Lucassen P, Marlatt M, Krugers H, Joels M, Van Leuven F, Swaab D, Verwer R, Boekhoorn K. S.16.01 Neurogenesis in relation to aging and dementia European Neuropsychopharmacology. 18: S178. DOI: 10.1016/S0924-977X(08)70173-1  0.431
2007 Verwer RW, Sluiter AA, Balesar RA, Baayen JC, Noske DP, Dirven CM, Wouda J, van Dam AM, Lucassen PJ, Swaab DF. Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin. Brain : a Journal of Neurology. 130: 3321-35. PMID 18055496 DOI: 10.1093/Brain/Awm264  0.497
2007 Oomen CA, Mayer JL, de Kloet ER, Joëls M, Lucassen PJ. Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress. The European Journal of Neuroscience. 26: 3395-401. PMID 18052970 DOI: 10.1111/J.1460-9568.2007.05972.X  0.338
2007 Kuhn HG, Cooper-Kuhn CM, Boekhoorn K, Lucassen PJ. Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant? European Archives of Psychiatry and Clinical Neuroscience. 257: 281-9. PMID 17639447 DOI: 10.1007/S00406-007-0732-4  0.36
2007 Joëls M, Karst H, Krugers HJ, Lucassen PJ. Chronic stress: implications for neuronal morphology, function and neurogenesis. Frontiers in Neuroendocrinology. 28: 72-96. PMID 17544065 DOI: 10.1016/J.Yfrne.2007.04.001  0.346
2007 Czéh B, Lucassen PJ. What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated? European Archives of Psychiatry and Clinical Neuroscience. 257: 250-60. PMID 17401728 DOI: 10.1007/S00406-007-0728-0  0.363
2007 Sennvik K, Boekhoorn K, Lasrado R, Terwel D, Verhaeghe S, Korr H, Schmitz C, Tomiyama T, Mori H, Krugers H, Joels M, Ramakers GJ, Lucassen PJ, Van Leuven F. Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2149-61. PMID 17341679 DOI: 10.1096/Fj.06-7735Com  0.308
2006 Lucassen PJ, Heine VM, Muller MB, van der Beek EM, Wiegant VM, De Kloet ER, Joels M, Fuchs E, Swaab DF, Czeh B. Stress, depression and hippocampal apoptosis. Cns & Neurological Disorders Drug Targets. 5: 531-46. PMID 17073656 DOI: 10.2174/187152706778559273  0.491
2006 Mayer JL, Klumpers L, Maslam S, de Kloet ER, Joëls M, Lucassen PJ. Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis. Journal of Neuroendocrinology. 18: 629-31. PMID 16867184 DOI: 10.1111/J.1365-2826.2006.01455.X  0.335
2006 Boekhoorn K, Joels M, Lucassen PJ. Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus. Neurobiology of Disease. 24: 1-14. PMID 16814555 DOI: 10.1016/J.Nbd.2006.04.017  0.333
2005 Swaab DF, Bao AM, Lucassen PJ. The stress system in the human brain in depression and neurodegeneration. Ageing Research Reviews. 4: 141-94. PMID 15996533 DOI: 10.1016/J.Arr.2005.03.003  0.706
2005 Heine VM, Zareno J, Maslam S, Joëls M, Lucassen PJ. Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expression. The European Journal of Neuroscience. 21: 1304-14. PMID 15813940 DOI: 10.1111/J.1460-9568.2005.03951.X  0.301
2004 Joëls M, Karst H, Alfarez D, Heine VM, Qin Y, van Riel E, Verkuyl M, Lucassen PJ, Krugers HJ. Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus. Stress (Amsterdam, Netherlands). 7: 221-31. PMID 16019587 DOI: 10.1080/10253890500070005  0.387
2004 Fuchs E, Czéh B, Kole MH, Michaelis T, Lucassen PJ. Alterations of neuroplasticity in depression: the hippocampus and beyond. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 14: S481-90. PMID 15550346 DOI: 10.1016/J.Euroneuro.2004.09.002  0.364
2004 Heine VM, Maslam S, Joëls M, Lucassen PJ. Increased P27KIP1 protein expression in the dentate gyrus of chronically stressed rats indicates G1 arrest involvement. Neuroscience. 129: 593-601. PMID 15541881 DOI: 10.1016/J.Neuroscience.2004.07.048  0.309
2004 van der Beek EM, Wiegant VM, Schouten WG, van Eerdenburg FJ, Loijens LW, van der Plas C, Benning MA, de Vries H, de Kloet ER, Lucassen PJ. Neuronal number, volume, and apoptosis of the left dentate gyrus of chronically stressed pigs correlate negatively with basal saliva cortisol levels. Hippocampus. 14: 688-700. PMID 15318328 DOI: 10.1002/Hipo.10213  0.347
2004 Heine VM, Maslam S, Joëls M, Lucassen PJ. Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activation. Neurobiology of Aging. 25: 361-75. PMID 15123342 DOI: 10.1016/S0197-4580(03)00090-3  0.324
2004 Lucassen PJ, Fuchs E, Czéh B. Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex. Biological Psychiatry. 55: 789-96. PMID 15050859 DOI: 10.1016/J.Biopsych.2003.12.014  0.355
2004 Heine VM, Maslam S, Zareno J, Joëls M, Lucassen PJ. Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible. The European Journal of Neuroscience. 19: 131-44. PMID 14750971 DOI: 10.1046/J.1460-9568.2003.03100.X  0.307
2003 DeRijk RH, Schaaf M, Stam FJ, de Jong IE, Swaab DF, Ravid R, Vreugdenhil E, Cidlowski JA, de Kloet ER, Lucassen PJ. Very low levels of the glucocorticoid receptor beta isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistry. Brain Research. Molecular Brain Research. 116: 17-26. PMID 12941457 DOI: 10.1016/S0169-328X(03)00209-2  0.484
2001 Müller MB, Lucassen PJ, Yassouridis A, Hoogendijk WJ, Holsboer F, Swaab DF. Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus. The European Journal of Neuroscience. 14: 1603-12. PMID 11860455 DOI: 10.1046/J.0953-816X.2001.01784.X  0.674
2001 Lucassen PJ, Vollmann-Honsdorf GK, Gleisberg M, Czéh B, De Kloet ER, Fuchs E. Chronic psychosocial stress differentially affects apoptosis in hippocampal subregions and cortex of the adult tree shrew. The European Journal of Neuroscience. 14: 161-6. PMID 11488960 DOI: 10.1046/J.0953-816X.2001.01629.X  0.343
2001 Fuchs E, Flügge G, Ohl F, Lucassen P, Vollmann-Honsdorf GK, Michaelis T. Psychosocial stress, glucocorticoids, and structural alterations in the tree shrew hippocampus. Physiology & Behavior. 73: 285-91. PMID 11438353 DOI: 10.1016/S0031-9384(01)00497-8  0.333
2001 Lucassen PJ, Müller MB, Holsboer F, Bauer J, Holtrop A, Wouda J, Hoogendijk WJ, De Kloet ER, Swaab DF. Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure. The American Journal of Pathology. 158: 453-68. PMID 11159183 DOI: 10.1016/S0002-9440(10)63988-0  0.651
2000 Simic G, Lucassen PJ, Krsnik Z, Kruslin B, Kostovic I, Winblad B, Bogdanovi. nNOS expression in reactive astrocytes correlates with increased cell death related DNA damage in the hippocampus and entorhinal cortex in Alzheimer's disease. Experimental Neurology. 165: 12-26. PMID 10964481 DOI: 10.1006/Exnr.2000.7448  0.309
1999 Vincent VA, De Groot CJ, Lucassen PJ, Portegies P, Troost D, Tilders FJ, Van Dam AM. Nitric oxide synthase expression and apoptotic cell death in brains of AIDS and AIDS dementia patients. Aids (London, England). 13: 317-26. PMID 10199221 DOI: 10.1097/00002030-199902250-00003  0.474
1998 Swaab DF, Lucassen PJ, Salehi A, Scherder EJ, van Someren EJ, Verwer RW. Reduced neuronal activity and reactivation in Alzheimer's disease. Progress in Brain Research. 117: 343-77. PMID 9932420 DOI: 10.1016/S0079-6123(08)64027-3  0.748
1998 Lucassen PJ, van Someren EJ, Swaab DF. [Are active neurons a better defense against aging in Alzheimer's disease?]. Tijdschrift Voor Gerontologie En Geriatrie. 29: 177-84. PMID 9746932  0.612
1998 Müller M, Lucassen P, Yassouridis A, Hoogendijk W, Holsboert F, Swaab D. No major pathology in the human hippocampus in major depression or following administration of glucocorticoids. A study on human post-mortem tissue European Neuropsychopharmacology. 8: S201. DOI: 10.1016/S0924-977X(98)80307-6  0.641
1997 Lucassen PJ, Tilders FJ, Salehi A, Swaab DF. Neuropeptides vasopressin (AVP), oxytocin (OXT) and corticotropin-releasing hormone (CRH) in the human hypothalamus: activity changes in aging, Alzheimer's disease and depression. Aging (Milan, Italy). 9: 48-50. PMID 9358882 DOI: 10.1007/Bf03339703  0.598
1997 Lucassen PJ, Chung WC, Kamphorst W, Swaab DF. DNA damage distribution in the human brain as shown by in situ end labeling; area-specific differences in aging and Alzheimer disease in the absence of apoptotic morphology. Journal of Neuropathology and Experimental Neurology. 56: 887-900. PMID 9258259 DOI: 10.1097/00005072-199708000-00007  0.716
1997 Lucassen PJ, Van Heerikhuize JJ, Guldenaar SE, Pool CW, Hofman MA, Swaab DF. Unchanged amounts of vasopressin mRNA in the supraoptic and paraventricular nucleus during aging and in Alzheimer's disease. Journal of Neuroendocrinology. 9: 297-305. PMID 9147293 DOI: 10.1046/J.1365-2826.1997.T01-1-00583.X  0.472
1996 Te Koppele JM, Lucassen PJ, Sakkee AN, Van Asten JG, Ravid R, Swaab DF, Van Bezooijen CF. 8OHdG levels in brain do not indicate oxidative DNA damage in Alzheimer's disease. Neurobiology of Aging. 17: 819-26. PMID 9363791 DOI: 10.1016/S0197-4580(96)00165-0  0.461
1996 Hoogendijk WJ, van Someren EJ, Mirmiran M, Hofman MA, Lucassen PJ, Zhou JN, Swaab DF. Circadian rhythm-related behavioral disturbances and structural hypothalamic changes in Alzheimer's disease. International Psychogeriatrics / Ipa. 8: 245-52; discussion 2. PMID 9154571 DOI: 10.1017/S1041610297003426  0.753
1996 Lucassen PJ, Goudsmit E, Pool CW, Mengod G, Palacios JM, Raadsheer FC, Guldenaar SE, Swaab DF. In situ hybridization for vasopressin mRNA in the human supraoptic and paraventricular nucleus; quantitative aspects of formalin-fixed paraffin-embedded tissue sections as compared to cryostat sections. Journal of Neuroscience Methods. 64: 133. PMID 8869492  0.35
1996 Swaab D, Raadsheer F, Lucassen P, Hoogendijk W, Tilders F. The activity of corticotropin releasing hormone (CRH) neurons in the human hypothalmus in relation to aging, Alzheimer's disease and depression European Psychiatry. 11: 194s. DOI: 10.1016/0924-9338(96)88552-X  0.625
1995 Lucassen PJ, Hofman MA, Swaab DF. Increased light intensity prevents the age related loss of vasopressin-expressing neurons in the rat suprachiasmatic nucleus. Brain Research. 693: 261-6. PMID 8653418 DOI: 10.1016/0006-8993(95)00933-H  0.453
1995 Raadsheer FC, van Heerikhuize JJ, Lucassen PJ, Hoogendijk WJ, Tilders FJ, Swaab DF. Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression. The American Journal of Psychiatry. 152: 1372-6. PMID 7653697 DOI: 10.1176/Ajp.152.9.1372  0.66
1995 Lucassen PJ, Goudsmit E, Pool CW, Mengod G, Palacios JM, Raadsheer FC, Guldenaar SE, Swaab DF. In situ hybridization for vasopressin mRNA in the human supraoptic and paraventricular nucleus; quantitative aspects of formalin-fixed paraffin-embedded tissue sections as compared to cryostat sections. Journal of Neuroscience Methods. 57: 221-30. PMID 7609586 DOI: 10.1016/0165-0270(94)00152-7  0.431
1995 Lucassen PJ, Chung WC, Vermeulen JP, Van Lookeren Campagne M, Van Dierendonck JH, Swaab DF. Microwave-enhanced in situ end-labeling of fragmented DNA: parametric studies in relation to postmortem delay and fixation of rat and human brain. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 43: 1163-71. PMID 7560899 DOI: 10.1177/43.11.7560899  0.712
1994 Salehi A, Lucassen PJ, Pool CW, Gonatas NK, Ravid R, Swaab DF. Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus. Neuroscience. 59: 871-80. PMID 8058125 DOI: 10.1016/0306-4522(94)90291-7  0.593
1994 Swaab DF, Hofman MA, Lucassen PJ, Salehi A, Uylings HB. Neuronal atrophy, not cell death, is the main hallmark of Alzheimer's disease. Neurobiology of Aging. 15: 369-71; discussion 3. PMID 7936066 DOI: 10.1016/0197-4580(94)90037-X  0.581
1994 Lucassen PJ, Salehi A, Pool CW, Gonatas NK, Swaab DF. Activation of vasopressin neurons in aging and Alzheimer's disease. Journal of Neuroendocrinology. 6: 673-9. PMID 7894470 DOI: 10.1111/J.1365-2826.1994.Tb00634.X  0.603
1993 Swaab DF, Hofman MA, Lucassen PJ, Purba JS, Raadsheer FC, Van de Nes JA. Functional neuroanatomy and neuropathology of the human hypothalamus. Anatomy and Embryology. 187: 317-30. PMID 8512084 DOI: 10.1007/Bf00185889  0.496
1993 Lucassen PJ, Ravid R, Gonatas NK, Swaab DF. Activation of the human supraoptic and paraventricular nucleus neurons with aging and in Alzheimer's disease as judged from increasing size of the Golgi apparatus. Brain Research. 632: 105-13. PMID 8149218 DOI: 10.1016/0006-8993(93)91144-H  0.477
1992 Swaab D, Grundke-Iqbal I, Iqbal K, Lucassen P, Raadsheer F, Ravid R, Van de Nes J. The human hypothalamus and Alzheimer symptoms Neurobiology of Aging. 13: S44. DOI: 10.1016/0197-4580(92)90299-D  0.427
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