Paul Marshall Mathews - Publications

Affiliations: 
Psychiatry New York University School of Medicine, New York, NY, United States 
Area:
Alzheimer's disease, APP metabolism, endocytosis
Website:
http://www.med.nyu.edu/people/mathep01.html

117 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Novy MJ, Newbury SF, Liemisa B, Morales-Corraliza J, Alldred MJ, Ginsberg SD, Mathews PM. Expression and proteolytic processing of the amyloid precursor protein is unaffected by the expression of the three human apolipoprotein E alleles in the brains of mice. Neurobiology of Aging. 110: 73-76. PMID 34875506 DOI: 10.1016/j.neurobiolaging.2021.10.015  0.396
2019 Mathews PM, Levy E. Exosome Production Is Key to Neuronal Endosomal Pathway Integrity in Neurodegenerative Diseases. Frontiers in Neuroscience. 13: 1347. PMID 31911768 DOI: 10.3389/Fnins.2019.01347  0.43
2019 Saadipour K, Tiberi A, Lomardo S, Grajales E, Montroull L, Mañucat-Tan NB, LaFrancois J, Cammer M, Mathews PM, Scharfman HE, Liao FF, Friedman WJ, Zhou XF, Tesco G, Chao MV. Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor. Molecular and Cellular Neurosciences. 103395. PMID 31422108 DOI: 10.1016/J.Mcn.2019.103395  0.35
2018 Peng KY, Pérez-González R, Alldred MJ, Goulbourne CN, Morales-Corraliza J, Saito M, Saito M, Ginsberg SD, Mathews PM, Levy E. Apolipoprotein E4 genotype compromises brain exosome production. Brain : a Journal of Neurology. PMID 30496349 DOI: 10.1093/Brain/Awy289  0.424
2018 Ross JA, Mathews PM, Van Bockstaele EJ. High resolution approaches for the identification of amyloid fragments in brain. Journal of Neuroscience Methods. PMID 30367888 DOI: 10.1016/J.Jneumeth.2018.10.032  0.514
2018 East BS, Fleming G, Peng K, Olofsson JK, Levy E, Mathews PM, Wilson DA. Human apolipoprotein E genotype differentially affects olfactory behavior and sensory physiology in mice. Neuroscience. PMID 29678753 DOI: 10.1016/J.Neuroscience.2018.04.009  0.353
2017 Nuriel T, Peng KY, Ashok A, Dillman AA, Figueroa HY, Apuzzo J, Ambat J, Levy E, Cookson MR, Mathews PM, Duff KE. The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo. Frontiers in Neuroscience. 11: 702. PMID 29311783 DOI: 10.3389/Fnins.2017.00702  0.479
2017 Cabrera E, Mathews P, Mezhericher E, Beach TG, Deng J, Neubert TA, Rostagno A, Ghiso J. Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition. Biochimica Et Biophysica Acta. PMID 28711595 DOI: 10.1016/J.Bbadis.2017.07.005  0.507
2016 Peng KY, Mathews PM, Levy E, Wilson DA. Apolipoprotein E4 causes early olfactory network abnormalities and short-term olfactory memory impairments. Neuroscience. PMID 28003161 DOI: 10.1016/J.Neuroscience.2016.12.004  0.344
2016 Mathews PM, Levy E. Cystatin C in aging and in Alzheimer's disease. Ageing Research Reviews. PMID 27333827 DOI: 10.1016/J.Arr.2016.06.003  0.447
2016 Morales-Corraliza J, Wong H, Mazzella MJ, Che S, Lee SH, Petkova E, Wagner JD, Hemby SE, Ginsberg SD, Mathews PM. Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 4248-58. PMID 27076423 DOI: 10.1523/Jneurosci.4640-14.2016  0.434
2016 Jiang Y, Rigoglioso A, Peterhoff CM, Pawlik M, Sato Y, Bleiwas C, Stavrides P, Smiley JF, Ginsberg SD, Mathews PM, Levy E, Nixon RA. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. Neurobiology of Aging. 39: 90-98. PMID 26923405 DOI: 10.1016/J.Neurobiolaging.2015.11.013  0.677
2015 Brautigam H, Moreno CL, Steele JW, Bogush A, Dickstein DL, Kwok JB, Schofield PR, Thinakaran G, Mathews PM, Hof PR, Gandy S, Ehrlich ME. Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin. Scientific Reports. 5: 17042. PMID 26608390 DOI: 10.1038/Srep17042  0.46
2015 Mahler J, Morales-Corraliza J, Stolz J, Skodras A, Radde R, Duma CC, Eisele YS, Mazzella MJ, Wong H, Klunk WE, Nilsson KP, Staufenbiel M, Mathews PM, Jucker M, Wegenast-Braun BM. Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice. Neurobiology of Aging. 36: 2241-7. PMID 25911278 DOI: 10.1016/J.Neurobiolaging.2015.03.011  0.542
2015 Schafer MJ, Alldred MJ, Lee SH, Calhoun ME, Petkova E, Mathews PM, Ginsberg SD. Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice. Neurobiology of Aging. 36: 1293-302. PMID 25556162 DOI: 10.1016/J.Neurobiolaging.2014.10.043  0.486
2015 Duffy AM, Morales-Corraliza J, Bermudez-Hernandez KM, Schaner MJ, Magagna-Poveda A, Mathews PM, Scharfman HE. Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age. Neurobiology of Aging. 36: 134-48. PMID 25109765 DOI: 10.1016/J.Neurobiolaging.2014.07.001  0.444
2013 Jeon AH, Böhm C, Chen F, Huo H, Ruan X, Ren CH, Ho K, Qamar S, Mathews PM, Fraser PE, Mount HT, St George-Hyslop P, Schmitt-Ulms G. Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2. The Journal of Biological Chemistry. 288: 15352-66. PMID 23589300 DOI: 10.1074/Jbc.M112.441840  0.455
2013 Choi JH, Kaur G, Mazzella MJ, Morales-Corraliza J, Levy E, Mathews PM. Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-β protein precursor transgenic mice. Journal of Alzheimer's Disease : Jad. 34: 691-700. PMID 23254640 DOI: 10.3233/Jad-122143  0.418
2013 Wesson DW, Morales-Corraliza J, Mazzella MJ, Wilson DA, Mathews PM. Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model. Behavioural Brain Research. 237: 96-102. PMID 23000537 DOI: 10.1016/J.Bbr.2012.09.019  0.392
2013 Papon MA, El Khoury NB, Marcouiller F, Julien C, Morin F, Bretteville A, Petry FR, Gaudreau S, Amrani A, Mathews PM, Hébert SS, Planel E. Deregulation of protein phosphatase 2A and hyperphosphorylation of Ï„ protein following onset of diabetes in NOD mice. Diabetes. 62: 609-17. PMID 22961084 DOI: 10.2337/Db12-0187  0.386
2013 Morales-Corraliza J, Schmidt SD, Mazzella MJ, Berger JD, Wilson DA, Wesson DW, Jucker M, Levy E, Nixon RA, Mathews PM. Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model. Neurobiology of Aging. 34: 137-45. PMID 22608241 DOI: 10.1016/J.Neurobiolaging.2012.04.007  0.668
2012 Schmidt SD, Mazzella MJ, Nixon RA, Mathews PM. Aβ measurement by enzyme-linked immunosorbent assay. Methods in Molecular Biology (Clifton, N.J.). 849: 507-27. PMID 22528112 DOI: 10.1007/978-1-61779-551-0_34  0.638
2012 Schmidt SD, Nixon RA, Mathews PM. Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including Aβ. Methods in Molecular Biology (Clifton, N.J.). 849: 493-506. PMID 22528111 DOI: 10.1007/978-1-61779-551-0_33  0.579
2012 Morales-Corraliza J, Berger JD, Mazzella MJ, Veeranna, Neubert TA, Ghiso J, Rao MV, Staufenbiel M, Nixon RA, Mathews PM. Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice. Neurobiology of Aging. 33: 1125.e9-18. PMID 22206846 DOI: 10.1016/J.Neurobiolaging.2011.11.023  0.647
2012 Morales-Corraliza J, Schmidt S, Mazzella M, Berger JD, Wilson D, Wesson D, Jucker M, Levy E, Nixon R, Mathews P. Immunization targeting a minor plaque constituent clears Aβ and rescues behavioral deficits in an Alzheimer's disease mouse model Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.1667  0.607
2011 Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, ... ... Mathews PM, et al. Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis. Autophagy. 7: 788-9. PMID 21464620 DOI: 10.4161/Auto.7.7.15596  0.661
2011 Tamboli IY, Hampel H, Tien NT, Tolksdorf K, Breiden B, Mathews PM, Saftig P, Sandhoff K, Walter J. Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1837-49. PMID 21289194 DOI: 10.1523/Jneurosci.2954-10.2011  0.571
2011 Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, ... ... Mathews PM, et al. Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain : a Journal of Neurology. 134: 258-77. PMID 21186265 DOI: 10.1093/Brain/Awq341  0.68
2011 Delay C, Calon F, Mathews P, Hébert SS. Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function Molecular Neurodegeneration. 6. DOI: 10.1186/1750-1326-6-70  0.379
2010 Coomaraswamy J, Kilger E, Wölfing H, Schäfer C, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, et al. Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 107: 7969-74. PMID 20385796 DOI: 10.1073/Pnas.1001056107  0.553
2010 Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, Nixon RA. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proceedings of the National Academy of Sciences of the United States of America. 107: 1630-5. PMID 20080541 DOI: 10.1073/Pnas.0908953107  0.686
2010 Krishnamurthy PK, Deng Y, Mathews PM, Sigurdsson EM. P1-355: Mechanistic studies of antibody mediated clearance of tau aggregates using an ex vivo brain slice model Alzheimer's & Dementia. 6: S276-S276. DOI: 10.1016/J.Jalz.2010.05.909  0.382
2010 Choi JH, Boyer-Boiteau A, Morales-Corraliza J, Ginsberg SD, Levy E, Mathews PM. P1-051: Dietary fat and cholesterol causes neuronal endosomal abnormalities and basal forebrain cholinergic neurodegeneration in wild-type mice Alzheimer's & Dementia. 6: S188-S188. DOI: 10.1016/J.Jalz.2010.05.599  0.316
2010 Coomaraswamy J, Kilger E, Woelfing H, Schaefer C, Kaeser SA, Wegenast-Braun B, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, et al. Modeling familial danish dementia: Implications for the amyloid hypothesis of Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.492  0.456
2010 Morales-Corraliza J, Mazzella MJ, Berger JD, Diaz NS, Choi JHK, Levy E, Matsuoka Y, Planel E, Mathews PM. In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: Greater stability of sAPP in the β-amyloid-depositing mice Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.477  0.441
2010 McIntee FL, Blais S, Neubert T, Mathews P, Rostagno A, Ghiso J. P3-212: Catabolism of Alzheimer's amyloid-β: Implications for brain clearance and plaque deposition Alzheimer's & Dementia. 6: S513-S513. DOI: 10.1016/J.Jalz.2010.05.1711  0.494
2010 Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, et al. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia Neuroforum. 16: 164-167.  0.423
2009 Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, et al. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nature Neuroscience. 12: 1361-3. PMID 19838177 DOI: 10.1515/Nf-2010-0107  0.553
2009 Morales-Corraliza J, Mazzella MJ, Berger JD, Diaz NS, Choi JH, Levy E, Matsuoka Y, Planel E, Mathews PM. In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice. Plos One. 4: e7134. PMID 19771166 DOI: 10.1371/Journal.Pone.0007134  0.553
2009 Choi JH, Berger JD, Mazzella MJ, Morales-Corraliza J, Cataldo AM, Nixon RA, Ginsberg SD, Levy E, Mathews PM. Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model. Journal of Neurochemistry. 110: 1818-27. PMID 19619138 DOI: 10.1111/J.1471-4159.2009.06277.X  0.646
2009 Mi W, Jung SS, Yu H, Schmidt SD, Nixon RA, Mathews PM, Tagliavini F, Levy E. Complexes of amyloid-beta and cystatin C in the human central nervous system. Journal of Alzheimer's Disease : Jad. 18: 273-80. PMID 19584436 DOI: 10.3233/Jad-2009-1147  0.681
2009 Bernardo A, Harrison FE, McCord M, Zhao J, Bruchey A, Davies SS, Jackson Roberts L, Mathews PM, Matsuoka Y, Ariga T, Yu RK, Thompson R, McDonald MP. Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice. Neurobiology of Aging. 30: 1777-91. PMID 18258340 DOI: 10.1016/J.Neurobiolaging.2007.12.022  0.513
2009 Puzzo D, Privitera L, Leznik E, Fa’ M, Staniszewsky A, Hashimoto G, Aziz F, Sakurai M, Ribe EM, Mathews PM, Troy CM, Mercken M, Jung SS, Palmeri A, Arancio O. O4-03-05: Amyloid-beta peptide is required for synaptic plasticity and memory Alzheimer's & Dementia. 5: P155-P155. DOI: 10.1016/J.Jalz.2009.05.535  0.343
2009 Grathwohl S, Kälin R, Bolmont T, Radde R, Odenthal J, Mazzella M, Käser S, Mathews PM, Eldh T, Wolburg H, Kohsaka S, Heppner FL, Jucker M. Formation and maintenance of β-amyloid plaques in the absence of microglia Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.04.899  0.399
2008 Trinchese F, Fa' M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. The Journal of Clinical Investigation. 118: 2796-807. PMID 18596919 DOI: 10.1172/Jci34254  0.574
2008 Cataldo AM, Mathews PM, Boiteau AB, Hassinger LC, Peterhoff CM, Jiang Y, Mullaney K, Neve RL, Gruenberg J, Nixon RA. Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects. The American Journal of Pathology. 173: 370-84. PMID 18535180 DOI: 10.2353/Ajpath.2008.071053  0.627
2008 Bai Y, Markham K, Chen F, Weerasekera R, Watts J, Horne P, Wakutani Y, Bagshaw R, Mathews PM, Fraser PE, Westaway D, St George-Hyslop P, Schmitt-Ulms G. The in vivo brain interactome of the amyloid precursor protein. Molecular & Cellular Proteomics : McP. 7: 15-34. PMID 17934213 DOI: 10.1074/Mcp.M700077-Mcp200  0.422
2008 Morales-Corraliza J, Berger JD, Mazzella MJ, Staufenbiel M, Rao MV, Nixon RA, Mathews PM. P1-079: Calpain inhibition by calpastatin overexpression reduces β-amyloid deposition in an APP transgenic mouse Alzheimer's & Dementia. 4: T229-T229. DOI: 10.1016/J.Jalz.2008.05.665  0.612
2008 Yang D, Stavrides P, Mohan P, Kumar A, Schmidt SD, Pawlik M, Bandyopadhyay U, Mathews PM, Levy E, Cuervo AM, Nixon RA. P1-059: Cystatin B deletion in a mouse model of Alzheimer's disease, TgCRND8, ameliorates both autophagic-lysosomal and amyloid pathologies Alzheimer's & Dementia. 4: T223-T223. DOI: 10.1016/J.Jalz.2008.05.645  0.642
2008 Choi JH, Diaz NS, Mazzella MJ, Ginsberg SD, Levy E, Nixon RA, Mathews PM. P1-011: Dysregulation of amyloid precursor protein levels, but not Aβ levels in Ts65Dn mouse brain Alzheimer's & Dementia. 4: T208-T209. DOI: 10.1016/J.Jalz.2008.05.596  0.628
2008 Mathews PM, Garcia-Osta A, Mazzella MJ, Alberini CM. O2-02-01: Endogenous Aβ enhances memory retention in the rat Alzheimer's & Dementia. 4: T133-T133. DOI: 10.1016/J.Jalz.2008.05.313  0.363
2008 Guénette SY, Wang L, Eckman EA, Robak A, Eckman CB, Mathews PM, Tanzi RE. O1-03-03: Reduced β-amyloid deposition in amyloid precursor protein transgenic mice lacking the insulin-degrading enzyme Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.231  0.421
2007 Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy E. Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nature Genetics. 39: 1440-2. PMID 18026100 DOI: 10.1038/Ng.2007.29  0.651
2007 Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao FF, Mathews PM, Xu H, Ehrlich ME. Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. Journal of Neurochemistry. 102: 619-26. PMID 17630980 DOI: 10.1111/J.1471-4159.2007.04587.X  0.658
2007 Elder GA, Cho JY, English DF, Franciosi S, Schmeidler J, Sosa MA, Gasperi RD, Fisher EA, Mathews PM, Haroutunian V, Buxbaum JD. Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor. Journal of Neurochemistry. 102: 1220-31. PMID 17472705 DOI: 10.1111/J.1471-4159.2007.04614.X  0.46
2007 Dorval V, Mazzella MJ, Mathews PM, Hay RT, Fraser PE. Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins. The Biochemical Journal. 404: 309-16. PMID 17346237 DOI: 10.1042/Bj20061451  0.526
2007 Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao F, Mathews PM, Xu H, Ehrlich ME. Erratum: Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo (Journal of Neurochemistry (2007) 102, (619-626)) Journal of Neurochemistry. 103. DOI: 10.1111/J.1471-4159.2007.04950.X  0.592
2007 Franciosi S, English D, Cho J, Buxbaum AR, Schmidt SD, Perez G, Mathews PM, De Gasperi R, Sosa MAG, Haroutunian V, Elder GA, Buxbaum JD. P-161: Amyloid beta (Aβ) is unaltered with highly elevated peripheral cholesterol in mice lacking the low-density lipoprotein receptor Alzheimer's & Dementia. 3: S150-S150. DOI: 10.1016/J.Jalz.2007.04.124  0.416
2006 Sano Y, Nakaya T, Pedrini S, Takeda S, Iijima-Ando K, Iijima K, Mathews PM, Itohara S, Gandy S, Suzuki T. Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP. Plos One. 1: e51. PMID 17183681 DOI: 10.1371/Journal.Pone.0000051  0.531
2006 Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, Lin AH, Crews L, Tremblay P, Mathews P, Mucke L, Masliah E, Wyss-Coray T. Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. The Journal of Clinical Investigation. 116: 3060-9. PMID 17080199 DOI: 10.1172/Jci27341  0.414
2006 Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, et al. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science (New York, N.Y.). 313: 1781-4. PMID 16990547 DOI: 10.1126/Science.1131864  0.529
2006 Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jäggi F, Wolburg H, Gengler S, Haass C, Ghetti B, Czech C, Hölscher C, Mathews PM, et al. Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. Embo Reports. 7: 940-6. PMID 16906128 DOI: 10.1038/Sj.Embor.7400784  0.514
2006 Tate BA, Mathews PM. Targeting the role of the endosome in the pathophysiology of Alzheimer's disease: a strategy for treatment. Science of Aging Knowledge Environment : Sage Ke. 2006: re2. PMID 16807486 DOI: 10.1126/sageke.2006.10.re2  0.44
2006 Jiang Y, Mullaney KA, Che S, Schmidt SD, Mathews PM, Cataldo AM, Ginsberg SD, Nixon RA. P2-061: APP expression modulates AD-related endosomal trafficking abnormalities in Down syndrome fibroblasts Alzheimer's & Dementia. 2: S250-S250. DOI: 10.1016/J.Jalz.2006.05.898  0.576
2006 Cataldo AM, Boyer-Boiteau A, Hassinger LC, Peterhoff CM, Jiang Y, Mathews PM, Neve RL, Nixon RA. P2-028 Alzheimer's & Dementia. 2: S240. DOI: 10.1016/J.Jalz.2006.05.865  0.45
2006 Choi JH, Diaz NS, Mazzella MJ, Peterson JN, Cataldo AM, Ginsberg SD, Levy E, Nixon RA, Mathews PM. P2-014: Dysregulation of brain APP in the Ts65Dn Down syndrome mouse Alzheimer's & Dementia. 2: S236-S236. DOI: 10.1016/J.Jalz.2006.05.851  0.536
2006 Mazzella MJ, Diaz NS, Berger J, Mathews PM. P2-002: Levels and turnover of endogenous APP metabolites in the wild-type mouse brain Alzheimer's & Dementia. 2: S232-S232. DOI: 10.1016/J.Jalz.2006.05.839  0.369
2006 Mastrangelo P, Arslanova D, Mazzella MJ, Strome R, Fraser PE, Boone C, Mathews PM, George-Hyslop PS, Westaway D. P1-079: Human gamma-secretase reconstituted in yeast via co-expression of presenilin, nicastrin, APH1A and PEN2 deviates from the prototype and implies the existence of auxiliary components Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.454  0.305
2006 Lee S, Paitel E, Drisaldi B, Petit A, Schmidt S, Mathews PM, Chen F, Fraser PE, George-Hyslop PS, Meijer L, Westaway D. P4-282: Effects of indirubin, a GSK3/CDK5 inhibitor, on the Aβ and tau pathways of Alzheimer’s Disease Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.2021  0.428
2006 Franciosi S, English D, Cho J, Buxbaum AR, Schmidt SD, Perez G, Mathews PM, DeGasperi R, Gama-Sosa M, Haroutunian V, Elder GA, Buxbaum JD. P4-081: Highly elevated peripheral cholesterol does not regulate brain cholesterol or levels of soluble amyloid beta (Aβ) Alzheimer's & Dementia. 2: S537-S537. DOI: 10.1016/J.Jalz.2006.05.1819  0.44
2005 Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Näslund J, Mathews PM, et al. Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. The Journal of Cell Biology. 171: 87-98. PMID 16203860 DOI: 10.1083/Jcb.200505082  0.761
2005 Schmidt SD, Nixon RA, Mathews PM. ELISA method for measurement of amyloid-beta levels. Methods in Molecular Biology (Clifton, N.J.). 299: 279-97. PMID 15980612 DOI: 10.1385/1-59259-874-9:279  0.679
2005 Schmidt SD, Jiang Y, Nixon RA, Mathews PM. Tissue processing prior to protein analysis and amyloid-beta quantitation. Methods in Molecular Biology (Clifton, N.J.). 299: 267-78. PMID 15980611 DOI: 10.1385/1-59259-874-9:267  0.603
2005 Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, et al. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proceedings of the National Academy of Sciences of the United States of America. 102: 8972-7. PMID 15951428 DOI: 10.1073/Pnas.0500940102  0.642
2004 Carter TL, Verdile G, Groth D, Bogush A, Thomas S, Shen P, Fraser PE, Mathews P, Nixon RA, Ehrlich ME, Kwok JB, St George-Hyslop P, Schofield P, Li Y, Yang A, et al. Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer Disease and Associated Disorders. 18: 261-3. PMID 15592142  0.591
2004 Sadowski M, Pankiewicz J, Scholtzova H, Ripellino JA, Li Y, Schmidt SD, Mathews PM, Fryer JD, Holtzman DM, Sigurdsson EM, Wisniewski T. A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice. The American Journal of Pathology. 165: 937-48. PMID 15331417 DOI: 10.1016/S0002-9440(10)63355-X  0.552
2004 Cataldo AM, Peterhoff CM, Schmidt SD, Terio NB, Duff K, Beard M, Mathews PM, Nixon RA. Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. Journal of Neuropathology and Experimental Neurology. 63: 821-30. PMID 15330337 DOI: 10.1093/Jnen/63.8.821  0.653
2004 Hasegawa H, Sanjo N, Chen F, Gu YJ, Shier C, Petit A, Kawarai T, Katayama T, Schmidt SD, Mathews PM, Schmitt-Ulms G, Fraser PE, St George-Hyslop P. Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes. The Journal of Biological Chemistry. 279: 46455-63. PMID 15322109 DOI: 10.1074/Jbc.M406289200  0.326
2004 Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Stürchler-Pierrat C, Bürki K, van Duinen SG, Maat-Schieman ML, Staufenbiel M, Mathews PM, Jucker M. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nature Neuroscience. 7: 954-60. PMID 15311281 DOI: 10.1038/Nn1302  0.567
2004 Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD, Parker CA, Callahan MJ, Lipinski WJ, Bisgaier CL, Turner BA, Nixon RA, Martins RN, Ouimet C, Smith JD, Davies P, ... ... Mathews PM, et al. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. Journal of Neurochemistry. 90: 1011-8. PMID 15287908 DOI: 10.1111/J.1471-4159.2004.02532.X  0.644
2004 Lacombe P, Mathews PM, Schmidt SD, Breidert T, Heneka MT, Landreth GE, Feinstein DL, Galea E. Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised. Journal of Neuroinflammation. 1: 11. PMID 15285804 DOI: 10.1186/1742-2094-1-11  0.424
2004 Sastre M, Calero M, Pawlik M, Mathews PM, Kumar A, Danilov V, Schmidt SD, Nixon RA, Frangione B, Levy E. Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation. Neurobiology of Aging. 25: 1033-43. PMID 15212828 DOI: 10.1016/J.Neurobiolaging.2003.11.006  0.639
2004 Trinchese F, Liu S, Battaglia F, Walter S, Mathews PM, Arancio O. Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice. Annals of Neurology. 55: 801-14. PMID 15174014 DOI: 10.1002/Ana.20101  0.485
2004 Pastorino L, Ikin AF, Lamprianou S, Vacaresse N, Revelli JP, Platt K, Paganetti P, Mathews PM, Harroch S, Buxbaum JD. BACE (beta-secretase) modulates the processing of APLP2 in vivo. Molecular and Cellular Neurosciences. 25: 642-9. PMID 15080893 DOI: 10.1016/J.Mcn.2003.12.013  0.505
2004 Laudon H, Karlström H, Mathews PM, Farmery MR, Gandy SE, Lundkvist J, Lendahl U, Näslund J. Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis. The Journal of Biological Chemistry. 279: 23925-32. PMID 15051718 DOI: 10.1074/Jbc.M401277200  0.435
2004 Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein. Journal of Neurochemistry. 89: 44-53. PMID 15030388 DOI: 10.1046/J.1471-4159.2003.02298.X  0.58
2004 Verdile G, Groth D, Mathews PM, St George-Hyslop P, Fraser PE, Ramabhadran TV, Kwok JB, Schofield PR, Carter T, Gandy S, Martins RN. Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells. Molecular Psychiatry. 9: 594-602. PMID 14993906 DOI: 10.1038/Sj.Mp.4001458  0.501
2004 Pawlik M, Sastre M, Calero M, Mathews PM, Schmidt SD, Nixon RA, Levy E. Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide. Journal of Molecular Neuroscience : Mn. 22: 13-8. PMID 14742906 DOI: 10.1385/Jmn:22:1-2:13  0.672
2004 Wisniewski T, Pankiewicz J, Scholtzova H, Schmidt SD, Mathews PM, Sigurdsson EM, Sadowski M. P4-381 Reduction of β-amyloid load in Alzheimer's disease transgenic mice by competitive blocking of β-amyloid binding to apolipoprotein E Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81939-0  0.448
2004 Verdile G, Groth D, Mathews P, George-Hyslop PS, Fraser P, Ramabhadran T, Kwok J, Schofield P, Carter T, Gandy S, Martins R. P4-265 Baculoviral expressionof the presenilin mutation lacking exon 9 increase levels of an amyloid beta — like protein in SF9insect cells Neurobiology of Aging. 25: S550-S551. DOI: 10.1016/S0197-4580(04)81823-2  0.412
2004 Zheng P, Jiang Y, Mohan PS, Mathews PM, Nixon RA. P3-292 AD-related cathepsin D overexpression promotes mitochondrial-dependent apoptosis Neurobiology of Aging. 25: S438. DOI: 10.1016/S0197-4580(04)81442-8  0.521
2004 Mastrangelo P, Mathews P, Chishti MA, Rozmahel R, Mercken M, Yang EJ, Mezzella M, Rogaev E, Schmidt S, Strome R, Ebeling C, Jiang Y, Nixon RA, Fraser P, Carlson G, et al. P2-100 Divergent effects of PS1 and PS2 upon gamma-40 and gamma-42-secretase activities of the mouse CNS Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80847-9  0.325
2004 Pawlik M, Sastre M, Calero M, Mathews PM, Kumar A, Schmidt SD, Nixon RA, Levy E. P2-061 Binding of cystatin C to amyloid beta inhibits amyloid fibril formation Neurobiology of Aging. 25: S241. DOI: 10.1016/S0197-4580(04)80808-X  0.603
2004 Cataldo AM, Mathews PM, Grbovic OM, Peterhoff CM, Jiang Y, Nixon RA. S5-02-03 Endosomal pathology in early stage Alzheimer's disease Neurobiology of Aging. 25: S90. DOI: 10.1016/S0197-4580(04)80305-1  0.561
2004 Nixon RA, Yu WH, Cuervo AM, Cataldo AM, Mathews PM, Yang D, Zheng P, Peterhoff CM, Kumar A, Jiang Y, Peterson J, Schmidt SD, Mohan P, Duff K, Hassinger L, et al. S4-03-04 Autophagy in Alzheimer's disease pathogenesis Neurobiology of Aging. 25: S70-S71. DOI: 10.1016/S0197-4580(04)80240-9  0.569
2004 Jucker M, Staufenbiel M, Mathews P. S3-01-06 Cerebral amyloid angiopathy in transgenic mouse models Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80156-8  0.464
2003 Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Chishti MA, Cox DW, Mathews PM, Nixon RA, Carlson GA, et al. In vivo reduction of amyloid-beta by a mutant copper transporter. Proceedings of the National Academy of Sciences of the United States of America. 100: 14193-8. PMID 14617772 DOI: 10.1073/Pnas.2332851100  0.646
2003 Mathews PM, Nixon RA. Setback for an Alzheimer's disease vaccine: lessons learned. Neurology. 61: 7-8. PMID 12847147 DOI: 10.1212/Wnl.61.1.7  0.639
2003 Burns M, Gaynor K, Olm V, Mercken M, LaFrancois J, Wang L, Mathews PM, Noble W, Matsuoka Y, Duff K. Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5645-9. PMID 12843267  0.429
2003 Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinakar R, Summers-Terio NB, Ceresa BP, Nixon RA, Cataldo AM. Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production. The Journal of Biological Chemistry. 278: 31261-8. PMID 12761223 DOI: 10.1074/Jbc.M304122200  0.691
2003 Meyer-Luehmann M, Stalder M, Herzig MC, Kaeser SA, Kohler E, Pfeifer M, Boncristiano S, Mathews PM, Mercken M, Abramowski D, Staufenbiel M, Jucker M. Extracellular amyloid formation and associated pathology in neural grafts. Nature Neuroscience. 6: 370-7. PMID 12598899 DOI: 10.1038/Nn1022  0.517
2003 Hasegawa H, Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti M, Horne P, Helsin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, et al. Aβ vaccination of a genetic model of Alzheimer's disease International Congress Series. 1252: 405-409. DOI: 10.1016/S0531-5131(03)00046-3  0.511
2002 Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M, Mathews PM, Jucker M. Cerebral hemorrhage after passive anti-Abeta immunotherapy. Science (New York, N.Y.). 298: 1379. PMID 12434053 DOI: 10.1126/Science.1078259  0.522
2002 Rozmahel R, Mount HT, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song YQ, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, et al. Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype. Proceedings of the National Academy of Sciences of the United States of America. 99: 14452-7. PMID 12388777 DOI: 10.1073/Pnas.222413999  0.609
2002 Mathews PM, Jiang Y, Schmidt SD, Grbovic OM, Mercken M, Nixon RA. Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments. The Journal of Biological Chemistry. 277: 36415-24. PMID 12087104 DOI: 10.1074/jbc.M205208200  0.546
2002 Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt SD, Ramabhadran TV, Nixon RA, Mathews PM, Gandy SE, Mount HT, St George-Hyslop P, et al. Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. The Journal of Biological Chemistry. 277: 28135-42. PMID 12032140 DOI: 10.1074/Jbc.M110871200  0.587
2002 Rozmahel R, Huang J, Chen F, Liang Y, Nguyen V, Ikeda M, Levesque G, Yu G, Nishimura M, Mathews P, Schmidt SD, Mercken M, Bergeron C, Westaway D, St George-Hyslop P. Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP. Neurobiology of Aging. 23: 187-94. PMID 11804702 DOI: 10.1016/S0197-4580(01)00267-6  0.392
2002 Mathews PM, Guerra CB, Jiang Y, Grbovic OM, Kao BH, Schmidt SD, Dinakar R, Mercken M, Hille-Rehfeld A, Rohrer J, Mehta P, Cataldo AM, Nixon RA. Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis. The Journal of Biological Chemistry. 277: 5299-307. PMID 11551970 DOI: 10.1074/Jbc.M108161200  0.559
2002 Westaway D, Janus C, Johnson H, Chishti MA, McLaurin J, Mathews P, Jiang Y, Schmidt SD, Horne P, French J, Nixon RA, Mercken M, Fraser PE, Bergeron C, Carlson GA, et al. Aβ-immunization reduces learning impairment and amyloid plaque burden in an animal model of Alzheimer's disease European Neuropsychopharmacology. 12: 98. DOI: 10.1016/S0924-977X(02)80030-X  0.471
2001 Nixon RA, Mathews PM, Cataldo AM. The neuronal endosomal-lysosomal system in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 3: 97-107. PMID 12214078 DOI: 10.3233/Jad-2001-3114  0.609
2000 Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 408: 979-82. PMID 11140685 DOI: 10.1038/35050110  0.624
2000 Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Lévesque L, et al. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease. Molecular Medicine (Cambridge, Mass.). 6: 878-91. PMID 11126202 DOI: 10.1007/Bf03401825  0.586
2000 Nixon RA, Cataldo AM, Mathews PM. The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review. Neurochemical Research. 25: 1161-72. PMID 11059790 DOI: 10.1023/A:1007675508413  0.626
2000 Mathews PM, Jiang Y, Guerra CB, Schmidt SD, Peterhoff CM, Cataldo AM, Nixon RA. Accelerated Aβ generation in AD models of lysosomal system upregulation Neurobiology of Aging. 21: 206. DOI: 10.1016/S0197-4580(00)83256-X  0.606
2000 Nixon RA, Cataldo AM, Mathews PM, Duff K, Guerra CB, Mohan P, Jiang Y, Peterhoff C. Endosomal-lysosomal mechanisms in amyloido-genesis and neurodegeneration: Animal models Neurobiology of Aging. 21: 72. DOI: 10.1016/S0197-4580(00)82543-9  0.477
1999 Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1. Molecular Medicine (Cambridge, Mass.). 5: 542-54. PMID 10501657 DOI: 10.1007/Bf03401981  0.578
1997 Capell A, Saffrich R, Olivo JC, Meyn L, Walter J, Grünberg J, Mathews P, Nixon R, Dotti C, Haass C. Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation. Journal of Neurochemistry. 69: 2432-40. PMID 9375676 DOI: 10.1046/J.1471-4159.1997.69062432.X  0.502
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