Juan C. Troncoso, MD - Related publications

Affiliations: 
Pathology Johns Hopkins University School of Medicine, Baltimore, MD, United States 
Area:
human neurodegenerative disorders, in particular Alzheimer's disease
Website:
http://www.alzresearch.org/team.cfm?ID=2
NOTE: We are testing a new system for identifying relevant work based on semantic analysis that identifies similarities between recently published papers and the current author's publications. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches.
50 most relevant papers in past 60 days:
Year Citation  Score
2020 d'Abramo C, D'Adamio L, Giliberto L. Significance of Blood and Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: Sensitivity, Specificity and Potential for Clinical Use. Journal of Personalized Medicine. 10. PMID 32911755 DOI: 10.3390/jpm10030116   
2020 Edler MK, Munger EL, Meindl RS, Hopkins WD, Ely JJ, Erwin JM, Mufson EJ, Hof PR, Sherwood CC, Raghanti MA. Neuron loss associated with age but not Alzheimer's disease pathology in the chimpanzee brain. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 375: 20190619. PMID 32951541 DOI: 10.1098/rstb.2019.0619   
2020 Narayanan SE, Sekhar N, Rajamma RG, Marathakam A, Al Mamun A, Uddin MS, Mathew B. Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer's Disease. Current Protein & Peptide Science. PMID 32957903 DOI: 10.2174/1389203721666200921152246   
2020 Garcia-Leon JA, Caceres-Palomo L, Sanchez-Mejias E, Mejias-Ortega M, Nuñez-Diaz C, Fernandez-Valenzuela JJ, Sanchez-Varo R, Davila JC, Vitorica J, Gutierrez A. Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32962164 DOI: 10.3390/ijms21186867   
2020 Bowerman M. Recent Advances and Future Perspectives in the Development of Therapeutic Approaches for Neurodegenerative Diseases. Brain Sciences. 10. PMID 32932920 DOI: 10.3390/brainsci10090633   
2020 Shen XN, Li JQ, Wang HF, Li HQ, Huang YY, Yang YX, Tan L, Dong Q, Yu JT, . Plasma amyloid, tau, and neurodegeneration biomarker profiles predict Alzheimer's disease pathology and clinical progression in older adults without dementia. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12104. PMID 33005724 DOI: 10.1002/dad2.12104   
2020 Shen XN, Li JQ, Wang HF, Li HQ, Huang YY, Yang YX, Tan L, Dong Q, Yu JT, . Plasma amyloid, tau, and neurodegeneration biomarker profiles predict Alzheimer's disease pathology and clinical progression in older adults without dementia. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12104. PMID 33005724 DOI: 10.1002/dad2.12104   
2020 Perea JR, Bolós M, Avila J. Microglia in Alzheimer's Disease in the Context of Tau Pathology. Biomolecules. 10. PMID 33066368 DOI: 10.3390/biom10101439   
2020 Low CYB, Lee JH, Lim FTW, Lee C, Ballard C, Francis PT, Lai MKP, Tan MGK. Isoform-specific upregulation of FynT kinase expression is associated with tauopathy and glial activation in Alzheimer's disease and Lewy body dementias. Brain Pathology (Zurich, Switzerland). e12917. PMID 33128789 DOI: 10.1111/bpa.12917   
2020 Alam J. Vitamins: a nutritional intervention to modulate the Alzheimer's disease progression. Nutritional Neuroscience. 1-18. PMID 32998670 DOI: 10.1080/1028415X.2020.1826762   
2020 Zamudio F, Loon AR, Smeltzer S, Benyamine K, Navalpur Shanmugam NK, Stewart NJF, Lee DC, Nash K, Selenica MB. TDP-43 mediated blood-brain barrier permeability and leukocyte infiltration promote neurodegeneration in a low-grade systemic inflammation mouse model. Journal of Neuroinflammation. 17: 283. PMID 32979923 DOI: 10.1186/s12974-020-01952-9   
2020 Ma WH, Chen AF, Xie XY, Huang YS. Sigma ligands as potent inhibitors of Aβ and AβOs in neurons and promising therapeutic agents of Alzheimer's disease. Neuropharmacology. 108342. PMID 33045243 DOI: 10.1016/j.neuropharm.2020.108342   
2020 Scholes HM, Cryar A, Kerr F, Sutherland D, Gethings LA, Vissers JPC, Lees JG, Orengo CA, Partridge L, Thalassinos K. Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila. Scientific Reports. 10: 18517. PMID 33116184 DOI: 10.1038/s41598-020-74748-9   
2020 Josephs KA, Martin PR, Weigand SD, Tosakulwong N, Buciuc M, Murray ME, Petrucelli L, Senjem ML, Spychalla AJ, Knopman DS, Boeve BF, Petersen RC, Parisi JE, Dickson DW, Jack CR, et al. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a Journal of Neurology. PMID 33150361 DOI: 10.1093/brain/awaa299   
2020 Corsetti V, Borreca A, Latina V, Giacovazzo G, Pignataro A, Krashia P, Natale F, Cocco S, Rinaudo M, Malerba F, Florio R, Ciarapica R, Coccurello R, D'Amelio M, Ammassari-Teule M, et al. Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer's disease models. Brain Communications. 2: fcaa039. PMID 32954296 DOI: 10.1093/braincomms/fcaa039   
2020 Barman NC, Khan NM, Islam M, Nain Z, Roy RK, Haque A, Barman SK. CRISPR-Cas9: A Promising Genome Editing Therapeutic Tool for Alzheimer's Disease-A Narrative Review. Neurology and Therapy. PMID 33089409 DOI: 10.1007/s40120-020-00218-z   
2020 Zhu F, Li C, Chu F, Tian X, Zhu J. Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer's Disease. Frontiers in Aging Neuroscience. 12: 544235. PMID 33132894 DOI: 10.3389/fnagi.2020.544235   
2020 Peng SY, Wu X, Lu T, Cui G, Chen G. Research progress of hydrogen sulfide in Alzheimer's disease from laboratory to hospital: a narrative review. Medical Gas Research. 10: 125-129. PMID 33004710 DOI: 10.4103/2045-9912.296043   
2020 Peng SY, Wu X, Lu T, Cui G, Chen G. Research progress of hydrogen sulfide in Alzheimer's disease from laboratory to hospital: a narrative review. Medical Gas Research. 10: 125-129. PMID 33004710 DOI: 10.4103/2045-9912.296043   
2020 Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC. Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32975365 DOI: 10.1002/alz.12185   
2020 Lin G, Ji K, Li S, Ma W, Pan X. The Genetics Analysis of Molecular Pathogenesis for Alzheimer's Disease. European Neurology. 1-10. PMID 33027797 DOI: 10.1159/000509799   
2020 Alcalà-Vida R, Awada A, Boutillier AL, Merienne K. Epigenetic mechanisms underlying enhancer modulation of neuronal identity, neuronal activity and neurodegeneration. Neurobiology of Disease. 147: 105155. PMID 33127472 DOI: 10.1016/j.nbd.2020.105155   
2020 Poon CH, Wang Y, Fung ML, Zhang C, Lim LW. Rodent Models of Amyloid-Beta Feature of Alzheimer's Disease: Development and Potential Treatment Implications. Aging and Disease. 11: 1235-1259. PMID 33014535 DOI: 10.14336/AD.2019.1026   
2020 Caldwell KA, Willicott CW, Caldwell GA. Modeling neurodegeneration in . Disease Models & Mechanisms. 13. PMID 33106318 DOI: 10.1242/dmm.046110   
2020 Dadar M, Camicioli R, Duchesne S, Collins DL, . The temporal relationships between white matter hyperintensities, neurodegeneration, amyloid beta, and cognition. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12091. PMID 33083512 DOI: 10.1002/dad2.12091   
2020 Siano G, Varisco M, Scarlatti A, Caiazza MC, Dunville K, Cremisi F, Costa M, Pancrazi L, Di Primio C, Cattaneo A. Gene expression of disease-related genes in Alzheimer's disease is impaired by Tau aggregation. Journal of Molecular Biology. PMID 33058882 DOI: 10.1016/j.jmb.2020.10.009   
2020 Qu X, Guan P, Han L, Wang Z, Huang X. Levistolide A Attenuates Alzheimer's Pathology Through Activation of the PPARγ Pathway. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33034847 DOI: 10.1007/s13311-020-00943-1   
2020 Li S, Wang C, Wang W, Tan J. Trait anxiety, a personality risk factor associated with Alzheimer's Disease. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 110124. PMID 33035604 DOI: 10.1016/j.pnpbp.2020.110124   
2020 Bell BJ, Malvankar MM, Tallon C, Slusher BS. Sowing the Seeds of Discovery: Tau-Propagation Models of Alzheimer's Disease. Acs Chemical Neuroscience. PMID 33050700 DOI: 10.1021/acschemneuro.0c00531   
2020 O'Connor A, Weston PSJ, Pavisic IM, Ryan NS, Collins JD, Lu K, Crutch SJ, Alexander DC, Fox NC, Oxtoby NP. Quantitative detection and staging of presymptomatic cognitive decline in familial Alzheimer's disease: a retrospective cohort analysis. Alzheimer's Research & Therapy. 12: 126. PMID 33023653 DOI: 10.1186/s13195-020-00695-2   
2020 Dong CM, Guo AS, To A, Chan KWY, Chow ASF, Bian L, Leong ATL, Wu EX. Early Detection of Amyloid β Pathology in Alzheimer's Disease by Molecular MRI. Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference. 2020: 1100-1103. PMID 33018178 DOI: 10.1109/EMBC44109.2020.9176013   
2020 Moynier F, Borgne ML, Laoud E, Mahan B, Mouton-Ligier F, Hugon J, Paquet C. Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12112. PMID 33102682 DOI: 10.1002/dad2.12112   
2020 Malarte ML, Nordberg A, Lemoine L. Characterization of MK6240, a tau PET tracer, in autopsy brain tissue from Alzheimer's disease cases. European Journal of Nuclear Medicine and Molecular Imaging. PMID 32970217 DOI: 10.1007/s00259-020-05035-y   
2020 Rafii MS, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Lai F, Rosas HD, Zaman S, Petersen ME, Strydom A, et al. The AT(N) framework for Alzheimer's disease in adults with Down syndrome. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12062. PMID 33134477 DOI: 10.1002/dad2.12062   
2020 Sun BL, Chen Y, Fan DY, Zhu C, Zeng F, Wang YJ. Critical thinking on amyloid-beta-targeted therapy: challenges and perspectives. Science China. Life Sciences. PMID 33106917 DOI: 10.1007/s11427-020-1810-y   
2020 Stevenson R, Samokhina E, Rossetti I, Morley JW, Buskila Y. Neuromodulation of Glial Function During Neurodegeneration. Frontiers in Cellular Neuroscience. 14: 278. PMID 32973460 DOI: 10.3389/fncel.2020.00278   
2020 Nunes MA, Toricelli M, Schöwe NM, Malerba HN, Dong-Creste KE, Farah DMAT, De Angelis K, Irigoyen MC, Gobeil F, Araujo Viel T, Buck HS. Kinin B2 Receptor Activation Prevents the Evolution of Alzheimer's Disease Pathological Characteristics in a Transgenic Mouse Model. Pharmaceuticals (Basel, Switzerland). 13. PMID 33019732 DOI: 10.3390/ph13100288   
2020 Rubinski A, Franzmeier N, Neitzel J, Ewers M, . FDG-PET hypermetabolism is associated with higher tau-PET in mild cognitive impairment at low amyloid-PET levels. Alzheimer's Research & Therapy. 12: 133. PMID 33076977 DOI: 10.1186/s13195-020-00702-6   
2020 Osama A, Zhang J, Yao J, Yao X, Fang J. Nrf2: a dark horse in Alzheimer's disease treatment. Ageing Research Reviews. 101206. PMID 33144124 DOI: 10.1016/j.arr.2020.101206   
2020 Mo D, Li X, Raabe CA, Rozhdestvensky TS, Skryabin BV, Brosius J. Circular RNA Encoded Amyloid Beta peptides-A Novel Putative Player in Alzheimer's Disease. Cells. 9. PMID 33003364 DOI: 10.3390/cells9102196   
2020 Ma Y, McClatchy DB, Martínez-Bartolomé S, Bamberger C, Yates JR. Temporal Quantitative Profiling of Newly Synthesized Proteins during Aβ Accumulation. Journal of Proteome Research. PMID 33147027 DOI: 10.1021/acs.jproteome.0c00645   
2020 Ju Y, Chakravarty H, Tam KY. An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease. Acs Chemical Neuroscience. PMID 33001625 DOI: 10.1021/acschemneuro.0c00464   
2020 Tan MS, Yang YX, Wang HF, Xu W, Tan CC, Zuo CT, Dong Q, Tan L, Yu JT, . PET Amyloid and Tau Status Are Differently Affected by Patient Features. Journal of Alzheimer's Disease : Jad. PMID 33104024 DOI: 10.3233/JAD-200124   
2020 Goedert M. Tau proteinopathies and the prion concept. Progress in Molecular Biology and Translational Science. 175: 239-259. PMID 32958235 DOI: 10.1016/bs.pmbts.2020.08.003   
2020 Wang L, Bharti, Kumar R, Pavlov PF, Winblad B. Small molecule therapeutics for tauopathy in Alzheimer's disease: Walking on the path of most resistance. European Journal of Medicinal Chemistry. 112915. PMID 33139110 DOI: 10.1016/j.ejmech.2020.112915   
2020 Ravona-Springer R, Sharvit-Ginon I, Ganmore I, Greenbaum L, Bendlin BB, Sternberg SA, Livny A, Domachevsky L, Sandler I, Ben Haim S, Golan S, Ben-Ami L, Lesman-Segev O, Manzali S, Heymann A, et al. The Israel Registry for Alzheimer's Prevention (IRAP) Study: Design and Baseline Characteristics. Journal of Alzheimer's Disease : Jad. PMID 33044181 DOI: 10.3233/JAD-200623   
2020 Darwich NF, Phan JM, Kim B, Suh E, Papatriantafyllou JD, Changolkar L, Nguyen AT, O'Rourke CM, He Z, Porta S, Gibbons GS, Luk KC, Papageorgiou SG, Grossman M, Massimo L, et al. Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. Science (New York, N.Y.). PMID 33004675 DOI: 10.1126/science.aay8826   
2020 Calvo-Rodriguez M, García-Rodríguez C, Villalobos C, Núñez L. Role of Toll Like Receptor 4 in Alzheimer's Disease. Frontiers in Immunology. 11: 1588. PMID 32983082 DOI: 10.3389/fimmu.2020.01588   
2020 Knopman DS, Lundt ES, Therneau TM, Albertson SM, Gunter JL, Senjem ML, Schwarz CG, Mielke MM, Machulda MM, Boeve BF, Jones DT, Graff-Radford J, Vemuri P, Kantarci K, Lowe VJ, ... , et al. Association of Initial β-Amyloid Levels With Subsequent Flortaucipir Positron Emission Tomography Changes in Persons Without Cognitive Impairment. Jama Neurology. PMID 33074304 DOI: 10.1001/jamaneurol.2020.3921   
2020 Albrecht D, Isenberg AL, Stradford J, Monreal T, Sagare A, Pachicano M, Sweeney M, Toga A, Zlokovic B, Chui H, Joe E, Schneider L, Conti P, Jann K, Pa J, , et al. Associations between vascular function and tau PET are associated with global cognition and amyloid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33046556 DOI: 10.1523/JNEUROSCI.1230-20.2020