Donald E. Schmechel, MD - Publications

Affiliations: 
Neurology Duke University, Durham, NC 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=127
Website:
http://toxicology.geneimprint.com/people/index.php?name=Schmechel.D

89 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Schmechel DE, Edwards CL. Fibromyalgia, mood disorders, and intense creative energy: A1AT polymorphisms are not always silent. Neurotoxicology. 33: 1454-72. PMID 22414631 DOI: 10.1016/J.Neuro.2012.03.001  0.301
2010 Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette CM, Schmechel D, Reiman EM, Rogers J, Stephan DA. Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology. Neurobiology of Aging. 31: 549-66. PMID 18572275 DOI: 10.1016/J.Neurobiolaging.2008.05.013  0.42
2008 Züchner S, Gilbert JR, Martin ER, Leon-Guerrero CR, Xu PT, Browning C, Bronson PG, Whitehead P, Schmechel DE, Haines JL, Pericak-Vance MA. Linkage and association study of late-onset Alzheimer disease families linked to 9p21.3. Annals of Human Genetics. 72: 725-31. PMID 18761660 DOI: 10.1111/J.1469-1809.2008.00474.X  0.378
2008 Sullivan PM, Mace BE, Estrada JC, Schmechel DE, Alberts MJ. Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. 17: 303-11. PMID 18755411 DOI: 10.1016/J.Jstrokecerebrovasdis.2008.03.011  0.352
2008 Carney RM, Slifer MA, Lin PI, Gaskell PC, Scott WK, Potocky CF, Hulette CM, Welsh-Bohmer KA, Schmechel DE, Vance JM, Pericak-Vance MA. Longitudinal follow-up of late-onset Alzheimer disease families. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 147: 571-8. PMID 18361431 DOI: 10.1002/Ajmg.B.30590  0.319
2008 Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Grover A, Niedzielko TL, Schneider LE, Mastroeni D, Caselli R, Kukull W, Morris JC, Hulette CM, Schmechel D, Rogers J, et al. Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. Proceedings of the National Academy of Sciences of the United States of America. 105: 4441-6. PMID 18332434 DOI: 10.1073/Pnas.0709259105  0.389
2008 Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette CM, Schmechel D, Reiman EM, Rogers J, Stephan DA. Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set. Physiological Genomics. 33: 240-56. PMID 18270320 DOI: 10.1152/Physiolgenomics.00242.2007  0.429
2007 Xu PT, Li YJ, Qin XJ, Kroner C, Green-Odlum A, Xu H, Wang TY, Schmechel DE, Hulette CM, Ervin J, Hauser M, Haines J, Pericak-Vance MA, Gilbert JR. A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. Molecular and Cellular Neurosciences. 36: 313-31. PMID 17822919 DOI: 10.1016/J.Mcn.2007.06.009  0.416
2007 Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Walker DG, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette C, Schmechel D, Alexander GE, Reiman EM, Rogers J, et al. Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. Physiological Genomics. 28: 311-22. PMID 17077275 DOI: 10.1152/Physiolgenomics.00208.2006  0.405
2006 Lin PI, Martin ER, Bronson PG, Browning-Large C, Small GW, Schmechel DE, Welsh-Bohmer KA, Haines JL, Gilbert JR, Pericak-Vance MA. Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease. Neurology. 67: 64-8. PMID 16832079 DOI: 10.1212/01.Wnl.0000223438.90113.4E  0.333
2006 Lin PI, Martin ER, Browning-Large CA, Schmechel DE, Welsh-Bohmer KA, Doraiswamy PM, Gilbert JR, Haines JL, Pericak-Vance MA. Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis. Neurogenetics. 7: 157-65. PMID 16770605 DOI: 10.1007/S10048-006-0047-Z  0.316
2006 Dunckley T, Beach TG, Ramsey KE, Grover A, Mastroeni D, Walker DG, LaFleur BJ, Coon KD, Brown KM, Caselli R, Kukull W, Higdon R, McKeel D, Morris JC, Hulette C, ... Schmechel D, et al. Gene expression correlates of neurofibrillary tangles in Alzheimer's disease. Neurobiology of Aging. 27: 1359-71. PMID 16242812 DOI: 10.1016/J.Neurobiolaging.2005.08.013  0.424
2006 Xu PT, Li YJ, Qin XJ, Scherzer CR, Xu H, Schmechel DE, Hulette CM, Ervin J, Gullans SR, Haines J, Pericak-Vance MA, Gilbert JR. Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. Neurobiology of Disease. 21: 256-75. PMID 16198584 DOI: 10.1016/J.Nbd.2005.07.004  0.412
2006 Bronson PG, Wall NN, Haines JL, Schmechel DE, Gilbert JR, Pericak-Vance MA, Martin ER. P1-345: Evidence for association between late-onset Alzheimer's disease and MTHFR on chromosome 1 Alzheimer's & Dementia. 2: S198-S198. DOI: 10.1016/J.Jalz.2006.05.723  0.353
2005 Martin ER, Bronson PG, Li YJ, Wall N, Chung RH, Schmechel DE, Small G, Xu PT, Bartlett J, Schnetz-Boutaud N, Haines JL, Gilbert JR, Pericak-Vance MA. Interaction between the alpha-T catenin gene (VR22) and APOE in Alzheimer's disease. Journal of Medical Genetics. 42: 787-92. PMID 16199552 DOI: 10.1136/Jmg.2004.029553  0.395
2005 Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, Rickman DW, Toth CA, Sullivan PM, Bowes Rickman C. Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 102: 11900-5. PMID 16079201 DOI: 10.1016/J.Ajo.2006.01.010  0.332
2005 Corder EH, Ervin JF, Lockhart E, Szymanski MH, Schmechel DE, Hulette CM. Cardiovascular damage in Alzheimer disease: autopsy findings from the Bryan ADRC. Journal of Biomedicine & Biotechnology. 2005: 189-97. PMID 16046825 DOI: 10.1155/Jbb.2005.189  0.386
2005 Mott RT, Dickson DW, Trojanowski JQ, Zhukareva V, Lee VM, Forman M, Van Deerlin V, Ervin JF, Wang DS, Schmechel DE, Hulette CM. Neuropathologic, biochemical, and molecular characterization of the frontotemporal dementias. Journal of Neuropathology and Experimental Neurology. 64: 420-8. PMID 15892300 DOI: 10.1093/Jnen/64.5.420  0.326
2005 Wang C, Wilson WA, Moore SD, Mace BE, Maeda N, Schmechel DE, Sullivan PM. Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. Neurobiology of Disease. 18: 390-8. PMID 15686968 DOI: 10.1016/J.Nbd.2004.10.013  0.378
2004 Nicodemus KK, Stenger JE, Schmechel DE, Welsh-Bohmer KA, Saunders AM, Roses AD, Gilbert JR, Vance JM, Haines JL, Pericak-Vance MA, Martin ER. Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease. Neurogenetics. 5: 201-8. PMID 15455263 DOI: 10.1007/S10048-004-0189-9  0.381
2004 Ervin JF, Pannell C, Szymanski M, Welsh-Bohmer K, Schmechel DE, Hulette CM. Vascular smooth muscle actin is reduced in Alzheimer disease brain: a quantitative analysis. Journal of Neuropathology and Experimental Neurology. 63: 735-41. PMID 15290898 DOI: 10.1093/Jnen/63.7.735  0.384
2004 van der Walt JM, Dementieva YA, Martin ER, Scott WK, Nicodemus KK, Kroner CC, Welsh-Bohmer KA, Saunders AM, Roses AD, Small GW, Schmechel DE, Murali Doraiswamy P, Gilbert JR, Haines JL, Vance JM, et al. Analysis of European mitochondrial haplogroups with Alzheimer disease risk. Neuroscience Letters. 365: 28-32. PMID 15234467 DOI: 10.1016/J.Neulet.2004.04.051  0.37
2004 Sullivan PM, Mace BE, Maeda N, Schmechel DE. Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice. Neuroscience. 124: 725-33. PMID 15026113 DOI: 10.1016/J.Neuroscience.2003.10.011  0.36
2004 Colton CA, Needham LK, Brown C, Cook D, Rasheed K, Burke JR, Strittmatter WJ, Schmechel DE, Vitek MP. APOE genotype-specific differences in human and mouse macrophage nitric oxide production. Journal of Neuroimmunology. 147: 62-7. PMID 14741429 DOI: 10.1016/J.Jneuroim.2003.10.015  0.379
2004 Quan H, Haines JL, Sanchez-Boutard N, Small G, Roses A, Schmechel D, Welsh-Bohmer K, Xu P, Li Y, Gilbert JR, Vance JM, Pericak-Vance MA. P4-138 Genomic convergence on chromosome 12 in Alzheimer's disease Neurobiology of Aging. 25: S514. DOI: 10.1016/S0197-4580(04)81696-8  0.313
2004 Martin E, Bronson P, Jiang L, Welsh-Bohmer K, Schmechel D, Small G, Haines J, Gilbert J, Pericak-Vance M, Moore J. P4-134 A multilocus association analysis of APOE, LRP1 and A2M in Alzheimer disease Neurobiology of Aging. 25: S513. DOI: 10.1016/S0197-4580(04)81692-0  0.38
2004 Gilbert JR, Xu P, Li Y, Qin X, Schmechel D, Hulette C, McLaurin A, Scherzer C, Gullans SR, Haines JL, Pericak-Vance MA. P4-103 APOE allele specific gene expression in Alzheimer's and control hippocampus Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81661-0  0.368
2004 Li Y, Oliveira SA, Qin X, Roses AD, Schmechel D, Welsh-Bohmer KA, Haines JL, Pericak-Vance MA, Vance JM. P4-088 Association analysis of interleukin 1 (IL-1) polymorphisms with age-at-onset and risk of Alzheimer disease Neurobiology of Aging. 25: S499. DOI: 10.1016/S0197-4580(04)81646-4  0.31
2004 Pericak-Vance MA, Bronson P, Martin ER, Browning C, Rayner M, Xu P, Small GW, Roses AD, Schmechel DE, Doraiswamy PM, Welsh-Bohmer KA, Haines JL, Gilbert JR. P4-080 Genetic studies of Alzheimer disease on chromosome 9P Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81638-5  0.318
2004 Browning C, Vance DD, Bronson PG, Schmechel D, Welsh-Bohmer K, Scott W, Haines JL, Vance JM, Pericak-Vance MA. P4-072 Follow-up analysis of chromosome 2 linkage in early-onset Alzheimer disease Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81630-0  0.343
2004 Xu P, Hulette C, Hauser M, Schmechel DE, Pericak-Vance MA, Gilbert JR. O1-03-06 Transcription analysis of APOE specific hippocampus in Alzheimer's disease (AD) using serial analysis of gene expression (SAGE) and long-SAGE Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80049-6  0.373
2003 Kulasingam SL, Samsa GP, Zarin DA, Rutschmann OT, Patwardhan MB, McCrory DC, Schmechel DE, Matchar DB. When should functional neuroimaging techniques be used in the diagnosis and management of Alzheimer's dementia? A decision analysis. Value in Health : the Journal of the International Society For Pharmacoeconomics and Outcomes Research. 6: 542-50. PMID 14627060 DOI: 10.1046/J.1524-4733.2003.65248.X  0.334
2003 Li YJ, Oliveira SA, Xu P, Martin ER, Stenger JE, Scherzer CR, Hauser MA, Scott WK, Small GW, Nance MA, Watts RL, Hubble JP, Koller WC, Pahwa R, Stern MB, ... ... Schmechel DE, et al. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Human Molecular Genetics. 12: 3259-67. PMID 14570706 DOI: 10.1093/Hmg/Ddg357  0.394
2003 Scott WK, Hauser ER, Schmechel DE, Welsh-Bohmer KA, Small GW, Roses AD, Saunders AM, Gilbert JR, Vance JM, Haines JL, Pericak-Vance MA. Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22. American Journal of Human Genetics. 73: 1041-51. PMID 14564669 DOI: 10.1086/379083  0.335
2003 Oliveira SA, Martin ER, Scott WK, Nicodemus KK, Small GW, Schmechel DE, Doraiswamy PM, Roses AD, Saunders AM, Gilbert JR, Haines JL, Vance JM, Pericak-Vance MA. The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease. Neuroscience Letters. 347: 143-6. PMID 12875906 DOI: 10.1016/S0304-3940(03)00670-0  0.403
2003 Trembath Y, Rosenberg C, Ervin JF, Schmechel DE, Gaskell P, Pericak-Vance M, Vance J, Hulette CM. Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease. Acta Neuropathologica. 105: 484-8. PMID 12677449 DOI: 10.1007/S00401-003-0670-9  0.334
2002 Colton CA, Brown CM, Cook D, Needham LK, Xu Q, Czapiga M, Saunders AM, Schmechel DE, Rasheed K, Vitek MP. APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. Neurobiology of Aging. 23: 777-85. PMID 12392781 DOI: 10.1016/S0197-4580(02)00016-7  0.344
2002 Li YJ, Scott WK, Hedges DJ, Zhang F, Gaskell PC, Nance MA, Watts RL, Hubble JP, Koller WC, Pahwa R, Stern MB, Hiner BC, Jankovic J, Allen FA, Goetz CG, ... ... Schmechel DE, et al. Age at onset in two common neurodegenerative diseases is genetically controlled. American Journal of Human Genetics. 70: 985-93. PMID 11875758 DOI: 10.1086/339815  0.36
2001 Sullivan P, Schmechel D, Hulette C, Ange R, Alberts MJ. Apolipoprotein E Transgenic Mouse Model of Cerebral Amyloid Angiopathy Stroke. 32: 329-329. DOI: 10.1161/01.Str.32.Suppl_1.329-C  0.35
2000 Martin ER, Lai EH, Gilbert JR, Rogala AR, Afshari AJ, Riley J, Finch KL, Stevens JF, Livak KJ, Slotterbeck BD, Slifer SH, Warren LL, Conneally PM, Schmechel DE, Purvis I, et al. SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. American Journal of Human Genetics. 67: 383-94. PMID 10869235 DOI: 10.1086/303003  0.365
2000 Martin ER, Gilbert JR, Lai EH, Riley J, Rogala AR, Slotterbeck BD, Sipe CA, Grubber JM, Warren LL, Conneally PM, Saunders AM, Schmechel DE, Purvis I, Pericak-Vance MA, Roses AD, et al. Analysis of association at single nucleotide polymorphisms in the APOE region. Genomics. 63: 7-12. PMID 10662539 DOI: 10.1006/Geno.1999.6057  0.319
2000 Hulette CM, Pannell C, Ervin JF, Rosenberg CK, Saunders AM, Strittmatter WJ, Schmechel DE. Vascular abnormalities in APOE4,4 and APOE3,3 Alzheimer's disease Neurobiology of Aging. 21: 271. DOI: 10.1016/S0197-4580(00)83173-5  0.352
2000 Sullivan PM, Mace BE, Schmechel DE. Targeted human apoE replacement mice provide a model for studying the role of apoE in Alzheimer's disease Neurobiology of Aging. 21: 18. DOI: 10.1016/S0197-4580(00)82756-6  0.356
1999 Hulette CM, Pericak-Vance MA, Roses AD, Schmechel DE, Yamaoka LH, Gaskell PC, Welsh-Bohmer KA, Crowther RA, Spillantini MG. Neuropathological features of frontotemporal dementia and parkinsonism linked to chromosome 17q21-22 (FTDP-17): Duke Family 1684. Journal of Neuropathology and Experimental Neurology. 58: 859-66. PMID 10446810 DOI: 10.1097/00005072-199908000-00008  0.383
1999 Rogaeva EA, Premkumar S, Grubber J, Serneels L, Scott WK, Kawarai T, Song Y, Hill DL, Abou-Donia SM, Martin ER, Vance JJ, Yu G, Orlacchio A, Pei Y, Nishimura M, ... ... Schmechel D, et al. An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease. Nature Genetics. 22: 19-22. PMID 10319855 DOI: 10.1038/8729  0.393
1999 Xu PT, Schmechel D, Qiu HL, Herbstreith M, Rothrock-Christian T, Eyster M, Roses AD, Gilbert JR. Sialylated human apolipoprotein E (apoEs) is preferentially associated with neuron-enriched cultures from APOE transgenic mice. Neurobiology of Disease. 6: 63-75. PMID 10078974 DOI: 10.1006/Nbdi.1998.0213  0.391
1999 Xu PT, Gilbert JR, Qiu HL, Ervin J, Rothrock-Christian TR, Hulette C, Schmechel DE. Specific regional transcription of apolipoprotein E in human brain neurons. The American Journal of Pathology. 154: 601-11. PMID 10027417 DOI: 10.1016/S0002-9440(10)65305-9  0.413
1998 Einstein G, Patel V, Bautista P, Kenna M, Melone L, Fader R, Karson K, Mann S, Saunders AM, Hulette C, Mash D, Roses AD, Schmechel DE. Intraneuronal ApoE in human visual cortical areas reflects the staging of Alzheimer disease pathology. Journal of Neuropathology and Experimental Neurology. 57: 1190-201. PMID 9862642 DOI: 10.1097/00005072-199812000-00011  0.433
1998 Xu PT, Gilbert JR, Qiu HL, Rothrock-Christian T, Settles DL, Roses AD, Schmechel DE. Regionally specific neuronal expression of human APOE gene in transgenic mice. Neuroscience Letters. 246: 65-8. PMID 9627181 DOI: 10.1016/S0304-3940(98)00247-X  0.439
1998 Roses AD, Gilbert J, Xu PT, Sullivan P, Popko B, Burkhart DS, Christian-Rothrock T, Saunders AM, Maeda N, Schmechel DE. Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice. Neurobiology of Aging. 19: S53-8. PMID 9562469 DOI: 10.1016/S0197-4580(98)00030-X  0.398
1998 Laskowitz DT, Matthew WD, Bennett ER, Schmechel D, Herbstreith MH, Goel S, McMillian MK. Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production. Neuroreport. 9: 615-8. PMID 9559926 DOI: 10.1097/00001756-199803090-00010  0.342
1998 Sheng H, Laskowitz DT, Bennett E, Schmechel DE, Bart RD, Saunders AM, Pearlstein RD, Roses AD, Warner DS. Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 18: 361-6. PMID 9538900 DOI: 10.1097/00004647-199804000-00003  0.338
1997 Piantadosi CA, Zhang J, Levin ED, Folz RJ, Schmechel DE. Apoptosis and delayed neuronal damage after carbon monoxide poisoning in the rat. Experimental Neurology. 147: 103-14. PMID 9294407 DOI: 10.1006/Exnr.1997.6584  0.305
1996 Xu PT, Schmechel D, Rothrock-Christian T, Burkhart DS, Qiu HL, Popko B, Sullivan P, Maeda N, Saunders AM, Roses AD, Gilbert JR. Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. Neurobiology of Disease. 3: 229-45. PMID 8980023 DOI: 10.1006/Nbdi.1996.0023  0.384
1996 Lane SC, Jolly RD, Schmechel DE, Alroy J, Boustany RM. Apoptosis as the mechanism of neurodegeneration in Batten's disease. Journal of Neurochemistry. 67: 677-83. PMID 8764595 DOI: 10.1046/J.1471-4159.1996.67020677.X  0.346
1996 Saunders AM, Hulette O, Welsh-Bohmer KA, Schmechel DE, Crain B, Burke JR, Alberts MJ, Strittmatter WJ, Breitner JC, Rosenberg C. Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease. Lancet (London, England). 348: 90-3. PMID 8676723 DOI: 10.1016/S0140-6736(96)01251-2  0.382
1996 Roses AD, Einstein G, Gilbert J, Goedert M, Han SH, Huang D, Hulette C, Masliah E, Pericak-Vance MA, Saunders AM, Schmechel DE, Strittmatter WJ, Weisgraber KH, Xi PT. Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. Annals of the New York Academy of Sciences. 777: 146-57. PMID 8624078 DOI: 10.1111/J.1749-6632.1996.Tb34413.X  0.419
1996 Stopa E, Vitek M, Rubin B, Schmechel D, Kuo-Leblanc. V, Wei Y, Song P, King J, Boteva K, Mitsuda N, Gilbert J, Roses A. 67 In-situ localization of S182 mRNA in sporadic Alzheimer's disease (AD) Neurobiology of Aging. 17: S17. DOI: 10.1016/S0197-4580(96)80069-8  0.362
1996 Roses A, Saunders A, Pericak-Vance M, Einstein G, Hulette C, Schmechel D, Huang D, Strittmatter W. Apolipoprotein is a susceptibility genetic locus that affects the expression of late-onset familial and sporadic Alzheimer's disease Biological Psychiatry. 39: 562. DOI: 10.1016/0006-3223(96)84162-X  0.352
1995 Roses AD, Saunders AM, Alberts MA, Strittmatter WJ, Schmechel D, Gorder E, Pericak-Vance MA. Apolipoprotein E E4 allele and risk of dementia. Jama. 273: 374-5; author reply . PMID 7823377 DOI: 10.1001/Jama.1995.03520290026015  0.376
1994 Roses AD, Pericak-Vance MA, Saunders AM, Schmechel D, Goldgaber D, Strittmatter W. Complex genetic disease: can genetic strategies in Alzheimer's disease and new genetic mechanisms be applied to epilepsy? Epilepsia. 35: S20-8. PMID 8293721 DOI: 10.1111/J.1528-1157.1994.Tb05925.X  0.334
1994 Han SH, Einstein G, Weisgraber KH, Strittmatter WJ, Saunders AM, Pericak-Vance M, Roses AD, Schmechel DE. Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study. Journal of Neuropathology and Experimental Neurology. 53: 535-44. PMID 8083695 DOI: 10.1097/00005072-199409000-00013  0.413
1994 Han SH, Hulette C, Saunders AM, Einstein G, Pericak-Vance M, Strittmatter WJ, Roses AD, Schmechel DE. Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. Experimental Neurology. 128: 13-26. PMID 8070517 DOI: 10.1006/Exnr.1994.1108  0.454
1994 Strittmatter WJ, Saunders AM, Goedert M, Weisgraber KH, Dong LM, Jakes R, Huang DY, Pericak-Vance M, Schmechel D, Roses AD. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 91: 11183-6. PMID 7972031 DOI: 10.1073/Pnas.91.23.11183  0.366
1994 Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskell PC, Rimmler JB, Locke PA, Conneally PM, Schmader KE. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nature Genetics. 7: 180-4. PMID 7920638 DOI: 10.1038/Ng0694-180  0.404
1994 Huang DY, Goedert M, Jakes R, Weisgraber KH, Garner CC, Saunders AM, Pericak-Vance MA, Schmechel DE, Roses AD, Strittmatter WJ. Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. Neuroscience Letters. 182: 55-8. PMID 7891887 DOI: 10.1016/0304-3940(94)90204-6  0.374
1994 Roses A, Saunders A, Corder E, Risch N, Haines J, Pericak-Vance M, Han S, Einstein G, Hulette C, Schmechel D, Goedert M, Jakes R, Dong L, Weisgraber K, Holsti M, et al. Apolipoprotein E-e4 and apolipoprotein E-e2 are susceptibility genes that affect the rate of disease expressivity of late-onset familial and sporadic Alzheimer disease Journal of the Neurological Sciences. 127: 2. DOI: 10.1016/0022-510X(94)90109-0  0.325
1993 Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 90: 1977-81. PMID 8446617 DOI: 10.1073/Pnas.90.5.1977  0.397
1993 Schmechel DE, Saunders AM, Strittmatter WJ, Crain BJ, Hulette CM, Joo SH, Pericak-Vance MA, Goldgaber D, Roses AD. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 90: 9649-53. PMID 8415756 DOI: 10.1073/Pnas.90.20.9649  0.382
1993 Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 43: 1467-72. PMID 8350998 DOI: 10.1212/Wnl.43.8.1467  0.42
1993 Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science (New York, N.Y.). 261: 921-3. PMID 8346443 DOI: 10.1126/Science.8346443  0.406
1988 Schmechel DE, Goldgaber D, Burkhart DS, Gilbert JR, Gajdusek DC, Roses AD. Cellular localization of messenger RNA encoding amyloid-beta-protein in normal tissue and in Alzheimer disease. Alzheimer Disease and Associated Disorders. 2: 96-111. PMID 3063300 DOI: 10.1097/00002093-198802020-00002  0.413
1987 Fitzpatrick D, Lund JS, Schmechel DE, Towles AC. Distribution of GABAergic neurons and axon terminals in the macaque striate cortex. The Journal of Comparative Neurology. 264: 73-91. PMID 3680625 DOI: 10.1002/Cne.902640107  0.309
1987 Schmechel DE, Marangos PJ, Martin BM, Winfield S, Burkhart DS, Roses AD, Ginns EI. Localization of neuron-specific enolase (NSE) mRNA in human brain. Neuroscience Letters. 76: 233-8. PMID 3587757 DOI: 10.1016/0304-3940(87)90721-X  0.377
1986 Lin CS, Lu SM, Schmechel DE. Glutamic acid decarboxylase and somatostatin immunoreactivities in rat visual cortex. The Journal of Comparative Neurology. 244: 369-83. PMID 2870090 DOI: 10.1002/Cne.902440309  0.319
1985 Walker LC, Kitt CA, Struble RG, Schmechel DE, Oertel WH, Cork LC, Price DL. Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques. Neuroscience Letters. 59: 165-9. PMID 2997667 DOI: 10.1016/0304-3940(85)90194-6  0.331
1984 Fitzpatrick D, Penny GR, Schmechel DE. Glutamic acid decarboxylase-immunoreactive neurons and terminals in the lateral geniculate nucleus of the cat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 4: 1809-29. PMID 6376726 DOI: 10.1523/Jneurosci.04-07-01809.1984  0.32
1984 Elde R, Seybold V, Sorenson RL, Cummings S, Holets V, Onstott D, Sasek C, Schmechel DE, Oertel WH. Peptidergic regulation in neuroendocrine and autonomic systems. Peptides. 5: 101-7. PMID 6148735 DOI: 10.1016/0196-9781(84)90269-9  0.316
1984 Schmechel DE, Vickrey BG, Fitzpatrick D, Elde RP. GABAergic neurons of mammalian cerebral cortex: widespread subclass defined by somatostatin content. Neuroscience Letters. 47: 227-32. PMID 6147798 DOI: 10.1016/0304-3940(84)90518-4  0.31
1983 Penny GR, Fitzpatrick D, Schmechel DE, Diamond IT. Glutamic acid decarboxylase-immunoreactive neurons and horseradish peroxidase-labeled projection neurons in the ventral posterior nucleus of the cat and Galago senegalensis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 3: 1868-87. PMID 6886749 DOI: 10.1523/Jneurosci.03-09-01868.1983  0.322
1983 Kirino T, Brightman MW, Oertel WH, Schmechel DE, Marangos PJ. Neuron-specific enolase as an index of neuronal regeneration and reinnervation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 3: 915-23. PMID 6842284 DOI: 10.1523/Jneurosci.03-05-00915.1983  0.306
1983 Oertel WH, Riethmüller G, Mugnaini E, Schmechel DE, Weindl A, Gramsch C, Herz A. Opioid peptide-like immunoreactivity localized in GABAErgic neurons of rat neostriatum and central amygdaloid nucleus. Life Sciences. 33: 73-6. PMID 6664248 DOI: 10.1016/0024-3205(83)90447-2  0.324
1981 Oertel WH, Schmechel DE, Mugnaini E, Tappaz ML, Kopin IJ. Immunocytochemical localization of glutamate decarboxylase in rat cerebellum with a new antiserum. Neuroscience. 6: 2715-35. PMID 7033824 DOI: 10.1016/0306-4522(81)90115-9  0.314
1980 Schmechel DE, Brightman MW, Barker JL. Localization of neuron-specific enolase in mouse spinal neurons grown in tissue culture. Brain Research. 181: 391-400. PMID 6985809 DOI: 10.1016/0006-8993(80)90621-6  0.309
1980 Schmechel DE, Brightman MW, Marangos PJ. Neurons switch from non-neuronal enolase to neuron-specific enolase during differentiation. Brain Research. 190: 195-214. PMID 6769533 DOI: 10.1016/0006-8993(80)91169-5  0.333
1980 Marangos PJ, Schmechel DE, Parma AM, Goodwin FK. Developmental profile of neuron-specific (NSE) and non-neuronal (NNE) enolase. Brain Research. 190: 185-93. PMID 6769532 DOI: 10.1016/0006-8993(80)91168-3  0.333
1979 Marangos PJ, Schmechel D, Parma AM, Clark RL, Goodwin FK. Measurement of neuron-specific (NSE) and non-neuronal (NNE) isoenzymes of enolase in rat, monkey and human nervous tissue. Journal of Neurochemistry. 33: 319-29. PMID 110910 DOI: 10.1111/J.1471-4159.1979.Tb11735.X  0.341
1978 Schmechel D, Marangos PJ, Zis AP, Brightman M, Goodwin FK. Brain endolases as specific markers of neuronal and glial cells. Science (New York, N.Y.). 199: 313-5. PMID 339349 DOI: 10.1126/Science.339349  0.333
1978 Schmechel D, Marangos PJ, Brightman M. Neurone-specific enolase is a molecular marker for peripheral and central neuroendocrine cells. Nature. 276: 834-6. PMID 31568 DOI: 10.1038/276834A0  0.353
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