Lawrence M. Sayre, PhD, University of California Berkeley, 1977 - Publications

Affiliations: 
Chemistry, Pathology, Environmental Health Sciences Case Western Reserve University, Cleveland Heights, OH, United States 
Website:
http://www.case.edu/artsci/chem/info/highlights/sayre_memorial.html

194 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Gao D, Sayre LM, Podrez EA. Analysis of relationship between oxidized phospholipid structure and interaction with the class B scavenger receptors. Methods in Molecular Biology (Clifton, N.J.). 1208: 29-48. PMID 25323497 DOI: 10.1007/978-1-4939-1441-8_3  1
2013 Perry EA, Castellani RJ, Moreira PI, Nunomura A, Lui Q, Harris PL, Sayre LM, Szweda PA, Szweda LI, Zhu X, Smith MA, Perry G. Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links. Free Radical Research. 47: 507-10. PMID 23566300 DOI: 10.3109/10715762.2013.794265  1
2012 Zhu X, Castellani RJ, Moreira PI, Aliev G, Shenk JC, Siedlak SL, Harris PL, Fujioka H, Sayre LM, Szweda PA, Szweda LI, Smith MA, Perry G. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover. Free Radical Biology & Medicine. 52: 699-704. PMID 22137893 DOI: 10.1016/j.freeradbiomed.2011.11.004  1
2011 Shibata T, Shimozu Y, Wakita C, Shibata N, Kobayashi M, Machida S, Kato R, Itabe H, Zhu X, Sayre LM, Uchida K. Lipid peroxidation modification of protein generates Nepsilon-(4-oxononanoyl)lysine as a pro-inflammatory ligand. The Journal of Biological Chemistry. 286: 19943-57. PMID 21471194 DOI: 10.1074/jbc.M110.187047  1
2011 Tang X, Sayre LM, Tochtrop GP. A mass spectrometric analysis of 4-hydroxy-2-(E)-nonenal modification of cytochrome c. Journal of Mass Spectrometry : Jms. 46: 290-7. PMID 21394845 DOI: 10.1002/jms.1890  1
2011 Ernberg K, Zhong B, Ko K, Miller L, Nguyen YH, Sayre LM, Guss JM, Lee I. Structural and enzyme activity studies demonstrate that aryl substituted 2,3-butadienamine analogs inactivate Arthrobacter globiformis amine oxidase (AGAO) by chemical derivatization of the 2,4,5-trihydroxyphenylalanine quinone (TPQ) cofactor. Biochimica Et Biophysica Acta. 1814: 638-46. PMID 21215824 DOI: 10.1016/j.bbapap.2010.12.016  1
2011 Liu Y, Zhang W, Sayre LM. An alternative total synthesis of pentosidine Journal of Heterocyclic Chemistry. 48: 426-433. DOI: 10.1002/jhet.611  1
2010 Zhu X, Tang X, Zhang J, Tochtrop GP, Anderson VE, Sayre LM. Mass spectrometric evidence for the existence of distinct modifications of different proteins by 2(E),4(E)-decadienal. Chemical Research in Toxicology. 23: 467-73. PMID 20070074 DOI: 10.1021/tx900379a  1
2010 Moreira PI, Sayre LM, Zhu X, Nunomura A, Smith MA, Perry G. Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease. Methods in Molecular Biology (Clifton, N.J.). 610: 419-34. PMID 20013193 DOI: 10.1007/978-1-60327-029-8_25  1
2010 Gao D, Ashraf MZ, Kar NS, Lin D, Sayre LM, Podrez EA. Structural basis for the recognition of oxidized phospholipids in oxidized low density lipoproteins by class B scavenger receptors CD36 and SR-BI. The Journal of Biological Chemistry. 285: 4447-54. PMID 19996318 DOI: 10.1074/jbc.M109.082800  1
2010 Liu Y, Zhang W, Sayre LM. A straightforward synthesis of pentosidine framework Journal of Heterocyclic Chemistry. 47: 683-686. DOI: 10.1002/jhet.374  1
2009 Zhang GF, Kombu RS, Kasumov T, Han Y, Sadhukhan S, Zhang J, Sayre LM, Ray D, Gibson KM, Anderson VA, Tochtrop GP, Brunengraber H. Catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs. The Journal of Biological Chemistry. 284: 33521-34. PMID 19759021 DOI: 10.1074/jbc.M109.055665  1
2009 Zhu X, Tang X, Anderson VE, Sayre LM. Mass spectrometric characterization of protein modification by the products of nonenzymatic oxidation of linoleic acid. Chemical Research in Toxicology. 22: 1386-97. PMID 19537826 DOI: 10.1021/tx9000072  1
2009 Zhu X, Anderson VE, Sayre LM. Charge-derivatized amino acids facilitate model studies on protein side-chain modifications by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 23: 2113-24. PMID 19517464 DOI: 10.1002/rcm.4116  1
2009 Zhu X, Gallogly MM, Mieyal JJ, Anderson VE, Sayre LM. Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal. Chemical Research in Toxicology. 22: 1050-9. PMID 19480392 DOI: 10.1021/tx9000144  1
2009 Lee HP, Zhu X, Zhu X, Skidmore SC, Perry G, Sayre LM, Smith MA, Lee HG. The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells. Journal of Neurochemistry. 108: 1434-41. PMID 19183271 DOI: 10.1111/j.1471-4159.2009.05883.x  1
2009 Ling KQ, Sayre LM. Discovery of a sensitive, selective, and tightly binding fluorogenic substrate of bovine plasma amine oxidase. The Journal of Organic Chemistry. 74: 339-50. PMID 19053593 DOI: 10.1021/jo8018945  1
2008 Ishino K, Shibata T, Ishii T, Liu YT, Toyokuni S, Zhu X, Sayre LM, Uchida K. Protein N-acylation: H2O2-mediated covalent modification of protein by lipid peroxidation-derived saturated aldehydes. Chemical Research in Toxicology. 21: 1261-70. PMID 18512967 DOI: 10.1021/tx800080x  1
2008 Ling KQ, Li WS, Sayre LM. Oxidations of N-(3-indoleethyl) cyclic aliphatic amines by horseradish peroxidase: the indole ring binds to the enzyme and mediates electron-transfer amine oxidation. Journal of the American Chemical Society. 130: 933-44. PMID 18163622 DOI: 10.1021/ja075905s  1
2008 Sayre LM, Perry G, Smith MA. Oxidative stress and neurotoxicity. Chemical Research in Toxicology. 21: 172-88. PMID 18052107 DOI: 10.1021/tx700210j  1
2007 Lin D, Zhang J, Sayre LM. Synthesis of six epoxyketooctadecenoic acid (EKODE) isomers, their generation from nonenzymatic oxidation of linoleic acid, and their reactivity with imidazole nucleophiles. The Journal of Organic Chemistry. 72: 9471-80. PMID 17979284 DOI: 10.1021/jo701373f  1
2007 Zhu X, Sayre LM. Long-lived 4-oxo-2-enal-derived apparent lysine michael adducts are actually the isomeric 4-ketoamides. Chemical Research in Toxicology. 20: 165-70. PMID 17305402 DOI: 10.1021/tx600295j  1
2007 Zhu X, Sayre LM. Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal. Redox Report : Communications in Free Radical Research. 12: 45-9. PMID 17263908 DOI: 10.1179/135100007X162176  1
2007 Yuan Q, Zhu X, Sayre LM. Chemical nature of stochastic generation of protein-based carbonyls: metal-catalyzed oxidation versus modification by products of lipid oxidation. Chemical Research in Toxicology. 20: 129-39. PMID 17226935 DOI: 10.1021/tx600270f  1
2007 Zhang Y, Ran C, Zhou G, Sayre LM. Highly potent 3-pyrroline mechanism-based inhibitors of bovine plasma amine oxidase and mass spectrometric confirmation of cofactor derivatization. Bioorganic & Medicinal Chemistry. 15: 1868-77. PMID 17150363 DOI: 10.1016/j.bmc.2006.11.025  1
2006 Sayre LM, Lin D, Yuan Q, Zhu X, Tang X. Protein adducts generated from products of lipid oxidation: focus on HNE and one. Drug Metabolism Reviews. 38: 651-75. PMID 17145694 DOI: 10.1080/03602530600959508  1
2006 Conklin DJ, Bhatnagar A, Cowley HR, Johnson GH, Wiechmann RJ, Sayre LM, Trent MB, Boor PJ. Acrolein generation stimulates hypercontraction in isolated human blood vessels. Toxicology and Applied Pharmacology. 217: 277-88. PMID 17095030 DOI: 10.1016/j.taap.2006.09.009  1
2006 Qiao C, Ling KQ, Shepard EM, Dooley DM, Sayre LM. Mechanism-based cofactor derivatization of a copper amine oxidase by a branched primary amine recruits the oxidase activity of the enzyme to turn inactivator into substrate. Journal of the American Chemical Society. 128: 6206-19. PMID 16669691 DOI: 10.1021/ja058838f  1
2006 Puttaiah S, Zhang Y, Pilch HA, Pfahler C, Oya-Ito T, Sayre LM, Nagaraj RH. Detection of dideoxyosone intermediates of glycation using a monoclonal antibody: characterization of major epitope structures. Archives of Biochemistry and Biophysics. 446: 186-96. PMID 16406213 DOI: 10.1016/j.abb.2005.12.002  1
2006 Kim J, Zhang Y, Ran C, Sayre LM. Inactivation of bovine plasma amine oxidase by haloallylamines. Bioorganic & Medicinal Chemistry. 14: 1444-53. PMID 16266805 DOI: 10.1016/j.bmc.2005.09.065  1
2006 Zhao S, Jeon HB, Nadkarni DV, Sayre LM. Acid-catalyzed rearrangement of 1-benzyl-2-methyl-3-piperidone to 1-benzyl-2-acetylpyrrolidine Tetrahedron. 62: 6361-6369. DOI: 10.1016/j.tet.2006.04.038  1
2005 Sayre LM, Moreira PI, Smith MA, Perry G. Metal ions and oxidative protein modification in neurological disease. Annali Dell'Istituto Superiore Di Sanità. 41: 143-64. PMID 16244388  1
2005 Lin D, Lee HG, Liu Q, Perry G, Smith MA, Sayre LM. 4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal. Chemical Research in Toxicology. 18: 1219-31. PMID 16097795 DOI: 10.1021/tx050080q  1
2005 Ling KQ, Sayre LM. Horseradish peroxidase-mediated aerobic and anaerobic oxidations of 3-alkylindoles. Bioorganic & Medicinal Chemistry. 13: 3543-51. PMID 15848767 DOI: 10.1016/j.bmc.2005.02.013  1
2005 Ling KQ, Sayre LM. A dopaquinone model that mimics the water addition step of cofactor biogenesis in copper amine oxidases. Journal of the American Chemical Society. 127: 4777-84. PMID 15796543 DOI: 10.1021/ja0455603  1
2005 Liu Q, Smith MA, Avilá J, DeBernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, ... ... Sayre LM, et al. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radical Biology & Medicine. 38: 746-54. PMID 15721985 DOI: 10.1016/j.freeradbiomed.2004.11.005  1
2005 Mandal S, Kazmi NH, Sayre LM. Ligand dependence in the copper-catalyzed oxidation of hydroquinones. Archives of Biochemistry and Biophysics. 435: 21-31. PMID 15680903 DOI: 10.1016/j.abb.2004.11.025  1
2005 Wu T, Ling KQ, Sayre LM, McIntire WS. Inhibition of murine N1-acetylated polyamine oxidase by an acetylenic amine and the allenic amine, MDL 72527. Biochemical and Biophysical Research Communications. 326: 483-90. PMID 15582603 DOI: 10.1016/j.bbrc.2004.11.054  1
2004 Sayre LM, Harris PL, Perry G, Smith MA. In situ localization of nonenzymatic peroxidase-like activity of tissue-bound transition metals. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. Unit17.4. PMID 23045100 DOI: 10.1002/0471140856.tx1704s20  1
2004 Lamplot Z, Sebela M, Malon M, Lenobel R, Lemr K, Havlis J, Pec P, Qiao C, Sayre LM. 1,5-diamino-2-pentyne is both a substrate and inactivator of plant copper amine oxidases. European Journal of Biochemistry / Febs. 271: 4696-708. PMID 15606757 DOI: 10.1111/j.1432-1033.2004.04434.x  1
2004 O'Connell KM, Langley DB, Shepard EM, Duff AP, Jeon HB, Sun G, Freeman HC, Guss JM, Sayre LM, Dooley DM. Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation. Biochemistry. 43: 10965-78. PMID 15323556 DOI: 10.1021/bi0492004  1
2004 Qiao C, Jeon HB, Sayre LM. Selective inhibition of bovine plasma amine oxidase by homopropargylamine, a new inactivator motif. Journal of the American Chemical Society. 126: 8038-45. PMID 15212554 DOI: 10.1021/ja049568o  1
2004 Liu Z, Minkler PE, Lin D, Sayre LM. Derivatization of amino acids with N,N-dimethyl-2,4-dinitro-5-fluorobenzylamine for liquid chromatography/electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 18: 1059-65. PMID 15150828 DOI: 10.1002/rcm.1443  1
2004 Shepard EM, Juda GA, Ling KQ, Sayre LM, Dooley DM. Cyanide as a copper and quinone-directed inhibitor of amine oxidases from pea seedlings ( Pisum sativum) and Arthrobacter globiformis: evidence for both copper coordination and cyanohydrin derivatization of the quinone cofactor. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 9: 256-68. PMID 14986071 DOI: 10.1007/s00775-004-0522-7  1
2004 Liu Y, Sun G, David A, Sayre LM. Model studies on the metal-catalyzed protein oxidation: structure of a possible His-Lys cross-link. Chemical Research in Toxicology. 17: 110-8. PMID 14727925 DOI: 10.1021/tx034167s  1
2004 Atwood CS, Perry G, Zeng H, Kato Y, Jones WD, Ling KQ, Huang X, Moir RD, Wang D, Sayre LM, Smith MA, Chen SG, Bush AI. Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta. Biochemistry. 43: 560-8. PMID 14717612 DOI: 10.1021/bi0358824  1
2004 Ran C, Zhang W, Sayre LM. Synthesis and protein reactivity of 2E,4E,6E-dodecatrienal Tetrahedron Letters. 45: 7851-7853. DOI: 10.1016/j.tetlet.2004.08.158  1
2004 Liu Z, Sayre LM. Synthesis of N,N-dimethyl-2,4-dinitro-5-fluorobenzylamine and its reactions with amino acids and peptides Tetrahedron. 60: 1601-1610. DOI: 10.1016/j.tet.2003.12.001  1
2003 Liu Y, Xu G, Sayre LM. Carnosine inhibits (E)-4-hydroxy-2-nonenal-induced protein cross-linking: structural characterization of carnosine-HNE adducts. Chemical Research in Toxicology. 16: 1589-97. PMID 14680373 DOI: 10.1021/tx034160a  1
2003 Jeon HB, Lee Y, Qiao C, Huang H, Sayre LM. Inhibition of bovine plasma amine oxidase by 1,4-diamino-2-butenes and -2-butynes. Bioorganic & Medicinal Chemistry. 11: 4631-41. PMID 14527560 DOI: 10.1016/S0968-0896(03)00521-2  1
2003 Liu Q, Raina AK, Smith MA, Sayre LM, Perry G. Hydroxynonenal, toxic carbonyls, and Alzheimer disease. Molecular Aspects of Medicine. 24: 305-13. PMID 12893008 DOI: 10.1016/S0098-2997(03)00025-6  1
2003 Liu Z, Minkler PE, Sayre LM. Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal. Chemical Research in Toxicology. 16: 901-11. PMID 12870893 DOI: 10.1021/tx0300030  1
2003 Jeon HB, Sayre LM. Highly potent propargylamine and allylamine inhibitors of bovine plasma amine oxidase. Biochemical and Biophysical Research Communications. 304: 788-94. PMID 12727226 DOI: 10.1016/S0006-291X(03)00681-8  1
2003 Zhang WH, Liu J, Xu G, Yuan Q, Sayre LM. Model studies on protein side chain modification by 4-oxo-2-nonenal. Chemical Research in Toxicology. 16: 512-23. PMID 12703968 DOI: 10.1021/tx020105a  1
2003 Jeon HB, Sun G, Sayre LM. Inactivation of bovine plasma amine oxidase by 4-aryloxy-2-butynamines and related analogs. Biochimica Et Biophysica Acta. 1647: 343-54. PMID 12686156 DOI: 10.1016/S1570-9639(03)00093-1  1
2003 Liu Z, Sayre LM. Model studies on the modification of proteins by lipoxidation-derived 2-hydroxyaldehydes. Chemical Research in Toxicology. 16: 232-41. PMID 12588195 DOI: 10.1021/tx020095d  1
2003 Ling KQ, Lee Y, Macikenas D, Protasiewicz JD, Sayre LM. Copper(II)-mediated autoxidation of tert-butylresorcinols. The Journal of Organic Chemistry. 68: 1358-66. PMID 12585875 DOI: 10.1021/jo020582y  1
2003 Tessier FJ, Monnier VM, Sayre LM, Kornfield JA. Triosidines: novel Maillard reaction products and cross-links from the reaction of triose sugars with lysine and arginine residues. The Biochemical Journal. 369: 705-19. PMID 12379150 DOI: 10.1042/BJ20020668  1
2002 Perry G, Nunomura A, Hirai K, Zhu X, Pérez M, Avila J, Castellani RJ, Atwood CS, Aliev G, Sayre LM, Takeda A, Smith MA. Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radical Biology & Medicine. 33: 1475-9. PMID 12446204 DOI: 10.1016/S0891-5849(02)01113-9  1
2002 Lee Y, Ling KQ, Lu X, Silverman RB, Shepard EM, Dooley DM, Sayre LM. 3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases. Journal of the American Chemical Society. 124: 12135-43. PMID 12371853 DOI: 10.1021/ja0205434  1
2002 Shepard EM, Smith J, Elmore BO, Kuchar JA, Sayre LM, Dooley DM. Towards the development of selective amine oxidase inhibitors. Mechanism-based inhibition of six copper containing amine oxidases. European Journal of Biochemistry / Febs. 269: 3645-58. PMID 12153561 DOI: 10.1046/j.1432-1033.2002.03035.x  1
2002 Perry G, Sayre LM, Atwood CS, Castellani RJ, Cash AD, Rottkamp CA, Smith MA. The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications. Cns Drugs. 16: 339-52. PMID 11994023  1
2002 Xu G, Sayre LM. Cross-linking of proteins by 3-(trifluoromethyl)-2,5-hexanedione. Model studies implicate an unexpected amine-dependent defluorinative substitution pathway competing with pyrrole formation. The Journal of Organic Chemistry. 67: 3007-14. PMID 11975560 DOI: 10.1021/jo011101y  1
2002 Smith MA, Drew KL, Nunomura A, Takeda A, Hirai K, Zhu X, Atwood CS, Raina AK, Rottkamp CA, Sayre LM, Friedland RP, Perry G. Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs? Neurochemistry International. 40: 527-31. PMID 11850109 DOI: 10.1016/S0197-0186(01)00123-1  1
2002 Castellani RJ, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J, Montine T, Sayre LM, Smith MA. Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans. Neuroscience Letters. 319: 25-8. PMID 11814645 DOI: 10.1016/S0304-3940(01)02514-9  1
2002 Wataya T, Nunomura A, Smith MA, Siedlak SL, Harris PL, Shimohama S, Szweda LI, Kaminski MA, Avila J, Price DL, Cleveland DW, Sayre LM, Perry G. High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. The Journal of Biological Chemistry. 277: 4644-8. PMID 11733539 DOI: 10.1074/jbc.M110913200  1
2002 Ling KQ, Ren T, Protasiewicz JD, Sayre LM. Structural correction of the 3-methylindole oxidatively-coupled dimer Tetrahedron Letters. 43: 6903-6905. DOI: 10.1016/S0040-4039(02)01623-4  1
2001 Ling KQ, Kim J, Sayre LM. Catalytic turnover of benzylamine by a model for the lysine tyrosylquinone (LTQ) cofactor of lysyl oxidase. Journal of the American Chemical Society. 123: 9606-11. PMID 11572681 DOI: 10.1021/ja011141j  1
2001 Campbell A, Smith MA, Sayre LM, Bondy SC, Perry G. Mechanisms by which metals promote events connected to neurodegenerative diseases. Brain Research Bulletin. 55: 125-32. PMID 11470308 DOI: 10.1016/S0361-9230(01)00455-5  1
2001 Castellani RJ, Harris PL, Sayre LM, Fujii J, Taniguchi N, Vitek MP, Founds H, Atwood CS, Perry G, Smith MA. Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine. Free Radical Biology & Medicine. 31: 175-80. PMID 11440829 DOI: 10.1016/S0891-5849(01)00570-6  1
2001 Sayre LM, Smith MA, Perry G. Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Current Medicinal Chemistry. 8: 721-38. PMID 11375746  1
2001 Lee Y, Jeon HB, Huang H, Sayre LM. Temporary inactivation of plasma amine oxidase by alkylhydrazines. A combined enzyme/model study implicates cofactor reduction/reoxidation but cofactor deoxygenation and subsequent reoxygenation in the case of hydrazine itself. The Journal of Organic Chemistry. 66: 1925-37. PMID 11300883 DOI: 10.1021/jo001115o  1
2001 Xu G, Singh MP, Gopal D, Sayre LM. Novel 2,5-hexanedione analogues. Substituent-induced control of the protein cross-linking potential and oxidation susceptibility of the resulting primary amine-derived pyrroles. Chemical Research in Toxicology. 14: 264-74. PMID 11258975 DOI: 10.1021/tx000169q  1
2001 Lee Y, Shepard E, Smith J, Dooley DM, Sayre LM. Catalytic turnover of substrate benzylamines by the quinone-dependent plasma amine oxidase leads to H2O2-dependent inactivation: evidence for generation of a cofactor-derived benzoxazole. Biochemistry. 40: 822-9. PMID 11170400 DOI: 10.1021/bi002118y  1
2001 VanOrman CA, Reddy KV, Sayre LM, Urbach FL. Dicopper(II) complexes with flexible binucleating ligands containing two tridentate coordination sites Polyhedron. 20: 541-549. DOI: 10.1016/S0277-5387(00)00660-4  1
2001 Li WS, Sayre LM. Reaction of amines with N1,N10-ethylene-bridged flavinium salts: The first NMR spectroscopic evidence of C10a tetrahedral amine adducts Tetrahedron. 57: 4523-4536. DOI: 10.1016/S0040-4020(01)00314-3  1
2001 Li WS, Zhang N, Sayre LM. N1,N10-Ethylene-bridged high-potential flavins: Synthesis, characterization, and reactivity Tetrahedron. 57: 4507-4522. DOI: 10.1016/S0040-4020(01)00313-1  1
2000 Rottkamp CA, Nunomura A, Hirai K, Sayre LM, Perry G, Smith MA. Will antioxidants fulfill their expectations for the treatment of Alzheimer disease? Mechanisms of Ageing and Development. 116: 169-79. PMID 10996017 DOI: 10.1016/S0047-6374(00)00124-X  1
2000 Podrez EA, Hoppe G, O'Neil J, Sayre LM, Sheibani N, Hoff HF. Macrophage receptors responsible for distinct recognition of low density lipoprotein containing pyrrole or pyridinium adducts: models of oxidized low density lipoprotein. Journal of Lipid Research. 41: 1455-63. PMID 10974053  1
2000 Mandal S, Macikenas D, Protasiewicz JD, Sayre LM. Novel tert-butyl migration in copper-mediated phenol ortho-oxygenation implicates a mechanism involving conversion of a 6-hydroperoxy-2,4-cyclohexadienone directly to an o-quinone The Journal of Organic Chemistry. 65: 4804-9. PMID 10956455 DOI: 10.1021/jo991625m  1
2000 Takeda A, Smith MA, Avilá J, Nunomura A, Siedlak SL, Zhu X, Perry G, Sayre LM. In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification. Journal of Neurochemistry. 75: 1234-41. PMID 10936206 DOI: 10.1046/j.1471-4159.2000.0751234.x  1
2000 Chun J, Kent UM, Moss RM, Sayre LM, Hollenberg PF. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 28: 905-11. PMID 10901699  1
2000 Salomon RG, Kaur K, Podrez E, Hoff HF, Krushinsky AV, Sayre LM. HNE-derived 2-pentylpyrroles are generated during oxidation of LDL, are more prevalent in blood plasma from patients with renal disease or atherosclerosis, and are present in atherosclerotic plaques. Chemical Research in Toxicology. 13: 557-64. PMID 10898587 DOI: 10.1021/tx000007u  1
2000 Sayre LM, Perry G, Atwood CS, Smith MA. The role of metals in neurodegenerative diseases. Cellular and Molecular Biology (Noisy-Le-Grand, France). 46: 731-41. PMID 10875436  1
2000 Rottkamp CA, Nunomura A, Raina AK, Sayre LM, Perry G, Smith MA. Oxidative stress, antioxidants, and Alzheimer disease. Alzheimer Disease and Associated Disorders. 14: S62-6. PMID 10850732 DOI: 10.1097/00002093-200000001-00010  1
2000 Raina AK, Perry G, Nunomura A, Sayre LM, Smith MA. Histochemical and immunocytochemical approaches to the study of oxidative stress. Clinical Chemistry and Laboratory Medicine : Cclm / Fescc. 38: 93-7. PMID 10834395 DOI: 10.1515/CCLM.2000.015  1
2000 Xu G, Liu Y, Sayre LM. Polyclonal antibodies to a fluorescent 4-hydroxy-2-nonenal (HNE)-derived lysine-lysine cross-link: characterization and application to HNE-treated protein and in vitro oxidized low-density lipoprotein. Chemical Research in Toxicology. 13: 406-13. PMID 10813658 DOI: 10.1021/tx990200s  1
2000 Perry G, Raina AK, Nunomura A, Wataya T, Sayre LM, Smith MA. How important is oxidative damage? Lessons from Alzheimer's disease. Free Radical Biology & Medicine. 28: 831-4. PMID 10754280 DOI: 10.1016/S0891-5849(00)00158-1  1
2000 Sayre LM, Perry G, Harris PL, Liu Y, Schubert KA, Smith MA. In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals. Journal of Neurochemistry. 74: 270-9. PMID 10617129 DOI: 10.1046/j.1471-4159.2000.0740270.x  1
2000 Mandal S, Lee Y, Purdy MM, Sayre LM. Chemical simulation of biogenesis of the 2,4,5-trihydroxyphenylalanine quinone cofactor of copper amine oxidases: Mechanistic distinctions point toward a unique role of the active site in the o-quinone water addition step Journal of the American Chemical Society. 122: 3574-3584. DOI: 10.1021/ja992886g  1
1999 Kean EL, Wei Z, Anderson VE, Zhang N, Sayre LM. Regulation of the biosynthesis of N-acetylglucosaminylpyrophosphoryldolichol, feedback and product inhibition. The Journal of Biological Chemistry. 274: 34072-82. PMID 10567375 DOI: 10.1074/jbc.274.48.34072  1
1999 Sayre LM, Perry G, Smith MA. In situ methods for detection and localization of markers of oxidative stress: application in neurodegenerative disorders. Methods in Enzymology. 309: 133-52. PMID 10507022 DOI: 10.1016/S0076-6879(99)09012-6  1
1999 Xu G, Sayre LM. Structural elucidation of a 2:2 4-ketoaldehyde-amine adduct as a model for lysine-directed cross-linking of proteins by 4-ketoaldehydes. Chemical Research in Toxicology. 12: 862-8. PMID 10490509 DOI: 10.1021/tx9900573  1
1999 Xu G, Liu Y, Kansal MM, Sayre LM. Rapid cross-linking of proteins by 4-ketoaldehydes and 4-hydroxy-2-alkenals does not arise from the lysine-derived monoalkylpyrroles. Chemical Research in Toxicology. 12: 855-61. PMID 10490508 DOI: 10.1021/tx990056a  1
1999 Sayre LM, Perry G, Smith MA. Redox metals and neurodegenerative disease. Current Opinion in Chemical Biology. 3: 220-5. PMID 10226049 DOI: 10.1016/S1367-5931(99)80035-0  1
1999 Xu G, Liu Y, Sayre LM. Independent synthesis, solution behavior, and studies on the mechanism of formation of a primary amine-derived fluorophore representing cross- linking of proteins by (E)-4-hydroxy-2-nonenal Journal of Organic Chemistry. 64: 5732-5745. DOI: 10.1021/jo982523j  1
1998 Kalaria RN, Premkumar DR, Lin CW, Kroon SN, Bae JY, Sayre LM, LaManna JC. Identification and expression of the Na+/H+ exchanger in mammalian cerebrovascular and choroidal tissues: characterization by amiloride-sensitive [3H]MIA binding and RT-PCR analysis. Brain Research. Molecular Brain Research. 58: 178-87. PMID 9685633 DOI: 10.1016/S0169-328X(98)00108-9  1
1998 Lee Y, Sayre LM. Reaffirmation that metabolism of polyamines by bovine plasma amine oxidase occurs strictly at the primary amino termini. The Journal of Biological Chemistry. 273: 19490-4. PMID 9677370 DOI: 10.1074/jbc.273.31.19490  1
1998 Smith MA, Sayre LM, Anderson VE, Harris PL, Beal MF, Kowall N, Perry G. Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 46: 731-5. PMID 9603784  1
1998 Xu G, Sayre LM. Structural characterization of a 4-hydroxy-2-alkenal-derived fluorophore that contributes to lipoperoxidation-dependent protein cross-linking in aging and degenerative disease. Chemical Research in Toxicology. 11: 247-51. PMID 9548794 DOI: 10.1021/tx980003d  1
1998 Castellani RJ, Perry G, Harris PL, Cohen ML, Sayre LM, Salomon RG, Smith MA. Advanced lipid peroxidation end-products in Alexander's disease. Brain Research. 787: 15-8. PMID 9518535 DOI: 10.1016/S0006-8993(97)01224-9  1
1998 Gopal D, Nadkarni DV, Sayre LM. A novel monoalkylation of symmetrical α-diones Tetrahedron Letters. 39: 1877-1880. DOI: 10.1016/S0040-4039(98)00306-2  1
1997 Hoppe G, O'Neil J, Sayre LM, Hoff HF. Non-conventional modification of low density lipoproteins: chemical models for macrophage recognition of oxidized LDL. Biochimica Et Biophysica Acta. 1362: 103-8. PMID 9540840 DOI: 10.1016/S0925-4439(97)00091-4  1
1997 Gopal D, Macikenas D, Sayre LM, Protasiewicz JD. Structural determination of a dimeric side-product accompanying dihydropyrazine preparation. Acta Chemica Scandinavica (Copenhagen, Denmark : 1989). 51: 938-41. PMID 9276917  1
1997 Smith MA, Harris PL, Sayre LM, Perry G. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proceedings of the National Academy of Sciences of the United States of America. 94: 9866-8. PMID 9275217 DOI: 10.1073/pnas.94.18.9866  1
1997 Sayre LM, Engelhart DA, Nadkarni DV, Manoj Babu MK, Flammang AM, McCoy GD. The role of iminium-enamine species in the toxication and detoxication of cyclic tertiary amines. Nida Research Monograph. 173: 106-27. PMID 9260186  1
1997 Nace CG, Genter MB, Sayre LM, Crofton KM. Effect of methimazole, an FMO substrate and competitive inhibitor, on the neurotoxicity of 3,3'-iminodipropionitrile in male rats. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 37: 131-40. PMID 9242586 DOI: 10.1006/faat.1997.2307  1
1997 Sayre LM, Gambetti P. Mechanistic importance of axonal atrophy and swelling in gamma-diketone axonopathy: commentary on forum position paper. Neurotoxicology. 18: 31-2; discussion 37-. PMID 9215984  1
1997 O'Neil J, Hoppe G, Sayre LM, Hoff HF. Inactivation of cathepsin B by oxidized LDL involves complex formation induced by binding of putative reactive sites exposed at low pH to thiols on the enzyme. Free Radical Biology & Medicine. 23: 215-25. PMID 9199883 DOI: 10.1016/S0891-5849(96)00612-0  1
1997 Sayre LM, Zagorski MG, Surewicz WK, Krafft GA, Perry G. Mechanisms of neurotoxicity associated with amyloid beta deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: a critical appraisal. Chemical Research in Toxicology. 10: 518-26. PMID 9168248 DOI: 10.1021/tx970009n  1
1997 Sayre LM, Zelasko DA, Harris PL, Perry G, Salomon RG, Smith MA. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. Journal of Neurochemistry. 68: 2092-7. PMID 9109537  1
1997 Smith MA, Richey Harris PL, Sayre LM, Beckman JS, Perry G. Widespread peroxynitrite-mediated damage in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 2653-7. PMID 9092586  1
1997 Nace CG, Genter MB, Sayre LM, Crofton KM. Effect of methimazole, an FMO substrate and competitive inhibitor, on the neurotoxicity of 3,3′-iminodipropionitrile in male rats Toxicological Sciences. 37: 131-140.  1
1996 Sayre LM. Alzheimer's precursor protein and the use of bathocuproine for determining reduction of copper(II) Science (New York, N.Y.). 274: 1933-4. PMID 8984650 DOI: 10.1126/science.274.5294.1933  1
1996 Sayre LM, Sha W, Xu G, Kaur K, Nadkarni D, Subbanagounder G, Salomon RG. Immunochemical evidence supporting 2-pentylpyrrole formation on proteins exposed to 4-hydroxy-2-nonenal. Chemical Research in Toxicology. 9: 1194-201. PMID 8902276 DOI: 10.1021/tx960094j  1
1996 Lin CW, Kalaria RN, Kroon SN, Bae JY, Sayre LM, LaManna JC. The amiloride-sensitive Na+/H+ exchange antiporter and control of intracellular pH in hippocampal brain slices. Brain Research. 731: 108-13. PMID 8883860 DOI: 10.1016/S0006-8993(96)00512-4  1
1996 Smith MA, Sayre LM, Monnier VM, Perry G. Oxidative posttranslational modifications in Alzheimer disease. A possible pathogenic role in the formation of senile plaques and neurofibrillary tangles. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 28: 41-8. PMID 8871940 DOI: 10.1007/BF02815203  1
1996 Sayre LM, Naismith RT, Bada MA, Li WS, Klein ME, Tennant MD. trans-2-phenylcyclopropylamine is a substrate for and inactivator of horseradish peroxidase. Biochimica Et Biophysica Acta. 1296: 250-6. PMID 8814233 DOI: 10.1016/0167-4838(96)00084-2  1
1996 Crofton KM, Zhao X, Sayre LM, Genter MB. Characterization of the effects of N-hydroxy-IDPN on the auditory, vestibular, and olfactory systems in rats. Neurotoxicology and Teratology. 18: 297-303. PMID 8725642 DOI: 10.1016/S0892-0362(96)90031-8  1
1996 Smith MA, Perry G, Richey PL, Sayre LM, Anderson VE, Beal MF, Kowall N. Oxidative damage in Alzheimer's. Nature. 382: 120-1. PMID 8700201 DOI: 10.1038/382120b0  1
1996 Smith MA, Sayre LM, Perry G. Diabetes mellitus and Alzheimer's disease: glycation as a biochemical link. Diabetologia. 39: 247. PMID 8635681 DOI: 10.1007/BF00403972  1
1996 Lee Y, Huang H, Sayre LM. Model studies support pyrrolylation of the topaquinone cofactor to explain inactivation of bovine plasma amine oxidase by 3-pyrrolines. Unusual processing of a secondary amine Journal of the American Chemical Society. 118: 7241-7242. DOI: 10.1021/ja9543210  1
1995 Smith MA, Monnier VM, Sayre LM, Perry G. Amyloidosis, advanced glycation end products and Alzheimer disease. Neuroreport. 6: 1595-6. PMID 8527721  1
1995 Sayre LM, Lee Y. Catalytic aerobic deamination of activated primary amines by a model for the quinone cofactor of mammalian copper amine oxidases. Methods in Enzymology. 258: 53-69. PMID 8524164 DOI: 10.1016/0076-6879(95)58037-9  1
1995 Smith MA, Sayre LM, Vitek MP, Monnier VM, Perry G. Early AGEing and Alzheimer's. Nature. 374: 316. PMID 7885469 DOI: 10.1038/374316b0  1
1995 Smith MA, Sayre LM, Monnier VM, Perry G. Radical AGEing in Alzheimer's disease. Trends in Neurosciences. 18: 172-6. PMID 7778188 DOI: 10.1016/0166-2236(95)93897-7  1
1995 Nadkarni DV, Sayre LM. Structural definition of early lysine and histidine adduction chemistry of 4-hydroxynonenal. Chemical Research in Toxicology. 8: 284-91. PMID 7766813  1
1995 Smith MA, Rudnicka-Nawrot M, Richey PL, Praprotnik D, Mulvihill P, Miller CA, Sayre LM, Perry G. Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease. Journal of Neurochemistry. 64: 2660-6. PMID 7539057  1
1995 He Z, Nadkarni DV, Sayre LM, Greenaway FT. Mechanism-based inactivation of porcine kidney diamine oxidase by 1,4-diamino-2-butene. Biochimica Et Biophysica Acta. 1253: 117-27. PMID 7492592 DOI: 10.1016/0167-4838(95)00158-Q  1
1995 Sayre LM, Engelhart DA, Nadkarni DV, Babu MK, Klein ME, McCoy G. Haemoprotein-mediated metabolism of enamines and the possible involvement of one-electron oxidations. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 25: 769-75. PMID 7483673 DOI: 10.3109/00498259509061892  1
1995 Smith MA, Monnier VM, Sayre LM, Perry G. Reply Trends in Neurosciences. 18: 342. DOI: 10.1016/0166-2236(95)90041-1  1
1995 Lee Y, Sayre LM. Model studies on the quinone-containing copper amine oxidases. Unambiguous demonstration of a transamination mechanism Journal of the American Chemical Society. 117: X-11827.  1
1995 Lee Y, Sayre LM. Model reactions for the quinone-containing copper amine oxidases. Anaerobic reaction pathways and catalytic aerobic deamination of activated amines in buffered aqueous acetonitrile Journal of the American Chemical Society. 117: 3096-3105.  1
1994 Smith MA, Taneda S, Richey PL, Miyata S, Yan SD, Stern D, Sayre LM, Monnier VM, Perry G. Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proceedings of the National Academy of Sciences of the United States of America. 91: 5710-4. PMID 8202552 DOI: 10.1073/pnas.91.12.5710  1
1994 Talafous J, Sayre LM, Mieyal JJ, Klopman G. META. 2. A dictionary model of mammalian xenobiotic metabolism. Journal of Chemical Information and Computer Sciences. 34: 1326-33. PMID 7989398  0.36
1994 Smith MA, Richey PL, Taneda S, Kutty RK, Sayre LM, Monnier VM, Perry G. Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease. Annals of the New York Academy of Sciences. 738: 447-54. PMID 7832455  1
1994 Bacci B, Cochran E, Nunzi MG, Izeki E, Mizutani T, Patton A, Hite S, Sayre LM, Autilio-Gambetti L, Gambetti P. Amyloid beta precursor protein and ubiquitin epitopes in human and experimental dystrophic axons. Ultrastructural localization. The American Journal of Pathology. 144: 702-10. PMID 7512790  1
1994 Wang F, Bae JY, Jacobson AR, Lee Y, Sayre LM. Synthesis and characterization of models for the 2,4,5-trihydroxyphenylalanine (TOPA)-derived cofactor of mammalian copper amine oxidases, and initial amine reactivity studies Journal of Organic Chemistry. 59: 2409-2417.  1
1994 Sayre LM, Nadkarni DV. Direct conversion of phenols to o-quinones by copper(I) dioxygen. Questions regarding the monophenolase activity of tyrosinase mimics Journal of the American Chemical Society. 116: 3157-3158.  1
1993 Berridge MS, Sayre LM, Arora PK, Terris AH, Riachi NJ, Harik SI. Design and synthesis of 18F-labeled neurotoxic analogs of MPTP. Journal of Medicinal Chemistry. 36: 1284-90. PMID 8487266  1
1993 Sayre LM, Arora PK, Iyer RS, Salomon RG. Pyrrole formation from 4-hydroxynonenal and primary amines. Chemical Research in Toxicology. 6: 19-22. PMID 8448343  1
1993 Harik SI, Riachi NJ, Hritz MA, Berridge MS, Sayre LM. Development of fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs with potent nigrostriatal toxicity for potential use in positron emission tomography studies. The Journal of Pharmacology and Experimental Therapeutics. 266: 790-5. PMID 8355208  1
1993 Tang W, Sayre LM. Divalent metal ion catalyzed hydrolysis of N-methyl-4′-nitro-6-carboxypicolinanilide. pH-Rate profile transitions and buffer inhibition Inorganic Chemistry. 32: 5785-5791.  1
1992 Wang F, Sayre LM. Kinetics and mechanism of aliphatic amine oxidation by aqueous (batho)2CuII Journal of the American Chemical Society. 114: 248-255.  1
1992 Sayre LM, Reddy KV, Jacobson AR, Tang W. Metal ion catalysis of amide hydrolysis. Very large rate enhancements by copper(II) in the hydrolysis of simple ligand-functionalized tertiary amides Inorganic Chemistry. 31: 935-937.  1
1992 Wang F, Venkataraman B, Klein ME, Sayre LM. Transaminative desilylation of (aminomethyl)trimethylsilane and transitory inactivation of plasma amine oxidase Journal of Organic Chemistry. 57: 6687-6689.  1
1991 Sayre LM, Wang FJ, Arora PK, Riachi NJ, Harik SI, Hoppel CL. Dopaminergic neurotoxicity in vivo and inhibition of mitochondrial respiration in vitro by possible endogenous pyridinium-like substances. Journal of Neurochemistry. 57: 2106-15. PMID 1940917  1
1991 Sayre LM, Engelhart DA, Venkataraman B, Babu MK, McCoy GD. Generation and fate of enamines in the microsomal metabolism of cyclic tertiary amines. Biochemical and Biophysical Research Communications. 179: 1368-76. PMID 1930182 DOI: 10.1016/0006-291X(91)91724-Q  1
1991 Singh MP, Wang FJ, Hoppel CL, Sayre LM. Inhibition of mitochondrial respiration by neutral, monocationic, and dicationic bis-pyridines related to the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium cation (MPP+). Archives of Biochemistry and Biophysics. 286: 138-46. PMID 1897943 DOI: 10.1016/0003-9861(91)90019-F  1
1991 Jacobson AR, Tam SW, Sayre LM. Modification of the enkephalin "message" with an artificial polycationic C-terminus. Journal of Medicinal Chemistry. 34: 2816-21. PMID 1895300  1
1991 Arora PK, Sayre LM. Copper-ammonia mediated oxidation of carbonyl compounds Tetrahedron Letters. 32: 1007-1010. DOI: 10.1016/S0040-4039(00)74473-X  1
1991 Veera Reddy K, Jacobson AR, Kung JI, Sayre LM. Divalent metal ion catalyzed hydrolysis of picolinanilides Inorganic Chemistry. 30: 3520-3525.  1
1991 Sayre LM, Singh MP, Kokil PB, Wang F. Non-electron-transfer quinone-mediated oxidative cleavage of cyclopropylamines. Implications regarding their utility as probes of enzyme mechanism Journal of Organic Chemistry. 56: 1353-1355.  1
1990 Sayre LM, Singh MP, Arora PK, Wang F, McPeak RJ, Hoppel CL. Inhibition of mitochondrial respiration by analogues of the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium: structural requirements for accumulation-dependent enhanced inhibitory potency on intact mitochondria. Archives of Biochemistry and Biophysics. 280: 274-83. PMID 2369119 DOI: 10.1016/0003-9861(90)90330-2  1
1990 Arora PK, Riachi NJ, Fiedler GC, Singh MP, Abdallah F, Harik SI, Sayre LM. Structure-neurotoxicity trends of analogues of 1-methyl-4-phenylpyridinium (MPP+), the cytotoxic metabolite of the dopaminergic neurotoxin MPTP. Life Sciences. 46: 379-90. PMID 2304377 DOI: 10.1016/0024-3205(90)90018-M  1
1990 Monaco S, Wongmongkolrit T, Shearson CM, Patton A, Schaetzle B, Autilio-Gambetti L, Gambetti P, Sayre LM. Giant axonopathy characterized by intermediate location of axonal enlargements and acceleration of neurofilament transport. Brain Research. 519: 73-81. PMID 2118823 DOI: 10.1016/0006-8993(90)90062-G  1
1990 Jin SJ, Arora PK, Sayre LM. Copper-mediated oxygenation of aldehydes and internal cannizzaro-like rearrangement of phenylglyoxal Journal of Organic Chemistry. 55: 3011-3018.  1
1990 Reddy KV, Jin SJ, Arora PK, Sfeir DS, Maloney SCF, Urbach FL, Sayre LM. Copper-mediated oxidative C-terminal N-dealkylation of peptide-derived ligands. A possible model for enzymatic generation of desglycine peptide amides Journal of the American Chemical Society. 112: 2332-2340.  1
1989 Sayre LM, Wang F, Hoppel CL. Tetraphenylborate potentiates the respiratory inhibition by the dopaminergic neurotoxin MPP+ in both electron transport particles and intact mitochondria. Biochemical and Biophysical Research Communications. 161: 809-18. PMID 2786720 DOI: 10.1016/0006-291X(89)92672-7  1
1989 Jacobson AR, Gintzler AR, Sayre LM. Minimum-structure enkephalin analogues incorporating L-tyrosine, D(or L)-phenylalanine, and a diamine spacer. Journal of Medicinal Chemistry. 32: 1708-17. PMID 2754695  1
1989 Sayre LM. Biochemical mechanism of action of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Toxicology Letters. 48: 121-49. PMID 2672418 DOI: 10.1016/0378-4274(89)90168-9  1
1989 Hiebert CK, Sayre LM, Silverman RB. Inactivation of monoamine oxidase by 3,3-dimethyl analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-2,3-dihydropyridinium ion. Dramatic effect of beta-mercaptoethanol on substrate turnover and enzyme inactivation. The Journal of Biological Chemistry. 264: 21516-21. PMID 2600079  1
1989 Wang F, Sayre LM. Oxidation of tertiary amine buffers by copper(II) [1] Inorganic Chemistry. 28: 169-170.  1
1988 Arora PK, Riachi NJ, Harik SI, Sayre LM. Chemical oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its in vivo metabolism in rat brain and liver. Biochemical and Biophysical Research Communications. 152: 1339-47. PMID 3259874 DOI: 10.1016/S0006-291X(88)80432-7  1
1988 Riachi NJ, Harik SI, Kalaria RN, Sayre LM. On the mechanisms underlying 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. II. Susceptibility among mammalian species correlates with the toxin's metabolic patterns in brain microvessels and liver. The Journal of Pharmacology and Experimental Therapeutics. 244: 443-8. PMID 3258032  1
1988 Riachi NJ, Arora PK, Sayre LM, Harik SI. Potent neurotoxic fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs as potential probes in models of Parkinson disease. Journal of Neurochemistry. 50: 1319-21. PMID 3258018  1
1988 Ehrlich BE, Jacobson AR, Hinrichsen R, Sayre LM, Forte MA. Paramecium calcium channels are blocked by a family of calmodulin antagonists. Proceedings of the National Academy of Sciences of the United States of America. 85: 5718-22. PMID 2456578  1
1987 Njoroge FG, Sayre LM, Monnier VM. Detection of D-glucose-derived pyrrole compounds during Maillard reaction under physiological conditions. Carbohydrate Research. 167: 211-20. PMID 3690569 DOI: 10.1016/0008-6215(87)80280-X  1
1987 Hoppel CL, Grinblatt D, Kwok HC, Arora PK, Singh MP, Sayre LM, Greenblatt D. Inhibition of mitochondrial respiration by analogs of 4-phenylpyridine and 1-methyl-4-phenylpyridinium cation (MPP+), the neurotoxic metabolite of MPTP. Biochemical and Biophysical Research Communications. 148: 684-93. PMID 3500717 DOI: 10.1016/0006-291X(87)90931-4  1
1987 Frank DM, Arora PK, Blumer JL, Sayre LM. Model study on the bioreduction of paraquat, MPP+, and analogs. Evidence against a "redox cycling" mechanism in MPTP neurotoxicity. Biochemical and Biophysical Research Communications. 147: 1095-104. PMID 3499150 DOI: 10.1016/S0006-291X(87)80183-3  1
1987 Jacobson AR, Coffin SH, Shearson CM, Sayre LM. beta,beta'-Iminodipropionitrile (IDPN) neurotoxicity: a mechanistic hypothesis for toxic activation. Molecular Toxicology. 1: 17-34. PMID 3449749  1
1987 Morandi A, Gambetti P, Arora PK, Sayre LM. Mechanism of neurotoxic action of beta,beta'-iminodipropionitrile (IDPN): N-hydroxylation enhances neurotoxic potency. Brain Research. 437: 69-76. PMID 3427483 DOI: 10.1016/0006-8993(87)91527-7  1
1987 Harik SI, Schmidley JW, Iacofano LA, Blue P, Arora PK, Sayre LM. On the mechanisms underlying 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: the effect of perinigral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, its metabolite and their analogs in the rat. The Journal of Pharmacology and Experimental Therapeutics. 241: 669-76. PMID 2437293  1
1987 Jacobson AR, Makris AN, Sayre LM. Monoacylation of symmetrical diamines Journal of Organic Chemistry. 52: 2592-2594.  1
1986 Sayre LM, Arora PK, Feke SC, Urbach FL. Mechanism of induction of Parkinson's disease by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Chemical and electrochemical characterization of a geminal-dimethyl-blocked analog of a postulated toxic metabolite. Journal of the American Chemical Society. 108: 2464-6. PMID 22175612 DOI: 10.1021/ja00269a065  0.76
1986 Sayre LM, Shearson CM, Wongmongkolrit T, Medori R, Gambetti P. Structural basis of gamma-diketone neurotoxicity: non-neurotoxicity of 3,3-dimethyl-2,5-hexanedione, a gamma-diketone incapable of pyrrole formation. Toxicology and Applied Pharmacology. 84: 36-44. PMID 3715867 DOI: 10.1016/0041-008X(86)90414-X  1
1986 Sayre LM, Arora PK, Iacofano LA, Harik SI. Comparative toxicity of MPTP, MPP+ and 3,3-dimethyl-MPDP+ to dopaminergic neurons of the rat substantia nigra. European Journal of Pharmacology. 124: 171-4. PMID 3487462 DOI: 10.1016/0014-2999(86)90139-1  1
1986 Portoghese PS, Larson DL, Sayre LM, Yim CB, Ronsisvalle G, Tam SW, Takemori AE. Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors. Journal of Medicinal Chemistry. 29: 1855-61. PMID 3020244  1
1986 Sayre LM, Arora PK, Feke SC, Urbach FL. Mechanism of induction of Parkinson's disease by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Chemical and electrochemical characterization of a geminal-dimethyl-blocked analogue of a postulated toxic metabolite Journal of the American Chemical Society. 108: 2464-2466.  1
1985 Portoghese PS, Larson DL, Yim CB, Sayre LM, Ronsisvalle G, Lipkowski AW, Takemori AE, Rice KC, Tam SW. Stereostructure-activity relationship of opioid agonist and antagonist bivalent ligands. Evidence for bridging between vicinal opioid receptors. Journal of Medicinal Chemistry. 28: 1140-1. PMID 2993609  1
1985 Sayre LM, Autilio-Gambetti L, Gambetti P. Pathogenesis of experimental giant neurofilamentous axonopathies: a unified hypothesis based on chemical modification of neurofilaments. Brain Research. 357: 69-83. PMID 2412663 DOI: 10.1016/0165-0173(85)90008-6  1
1984 Sayre LM, Larson DL, Takemori AE, Portoghese PS. Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different mu receptor subtypes in different tissues. Journal of Medicinal Chemistry. 27: 1325-35. PMID 6090663  1
1984 Sayre LM, Jin SJ. Mechanism of copper-catalyzed oxygenation of ketones Journal of Organic Chemistry. 49: 3498-3503.  1
1983 Sayre LM, Larson DL, Fries DS, Takemori AE, Portoghese PS. Importance of C-6 chirality in conferring irreversible opioid antagonism to naltrexone-derived affinity labels. Journal of Medicinal Chemistry. 26: 1229-35. PMID 6310111  1
1983 Sayre LM, Portoghese PS, Takemori AE. Difference between mu-receptors in the guinea pig ileum and the mouse vas deferens. European Journal of Pharmacology. 90: 159-60. PMID 6307720 DOI: 10.1016/0014-2999(83)90232-7  1
1983 Sayre LM, Takemori AE, Portoghese PS. Alkylation of opioid receptor subtypes by alpha-chlornaltrexamine produces concurrent irreversible agonistic and irreversible antagonistic activities. Journal of Medicinal Chemistry. 26: 503-6. PMID 6300401  1
1982 Portoghese PS, Ronsisvalle G, Larson DL, Yim CB, Sayre LM, Takemori AE. Opioid agonist and antagonist bivalent ligands as receptor probes. Life Sciences. 31: 1283-6. PMID 6292615 DOI: 10.1016/0024-3205(82)90362-9  1
1981 Moe GR, Sayre LM, Portoghese PS. An explanation for the failure of aminomethanesulfonic acid to form sulfonamides. Acyl chloride-promoted generation of α-carboxamidoalkylating electrophiles Tetrahedron Letters. 22: 537-540. DOI: 10.1016/S0040-4039(01)90148-0  1
1980 Portoghese PS, Larson DL, Sayre LM, Fries DS, Takemori AE. A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities. Journal of Medicinal Chemistry. 23: 233-4. PMID 6245210  1
1980 Sayre LM, Portoghese PS. Stereospecific synthesis of the 6α- and 6β-amino derivatives of naltrexone and oxymorphone Journal of Organic Chemistry. 45: 3366-3368.  1
1979 Sayre LM, Jensen FR. A rate sequence for SE2 retention with large steric and large electronic effects [17] Journal of the American Chemical Society. 101: 1900-1901.  1
1979 Sayre LM, Jensen FR. Mechanism in electrophilic aliphatic substitution: A kinetic and stereochemical study of bromodemercuration with bromide ion catalysis Journal of the American Chemical Society. 101: 6001-6008.  1
1979 Sayre LM, Jensen FR. Reduction of organomercurials by sodium dithionite Journal of Organic Chemistry. 44: 228-231.  1
1978 Sayre LM, Jensen FR. Novel decarboxylative oxidation of α-hydroxy-β-keto (or -β-imino) acid salts of mercury (II) Journal of Organic Chemistry. 43: 4700-4705.  1
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