Wendy Noble, PhD - Publications

Affiliations: 
Department or Neuroscience King's College London, London, UK 
Area:
Alzheimer's disease, tau

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Howard R, Zubko O, Bradley R, Harper E, Pank L, O'Brien J, Fox C, Tabet N, Livingston G, Bentham P, McShane R, Burns A, Ritchie C, Reeves S, Lovestone S, ... ... Noble W, et al. Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial. Jama Neurology. PMID 31738372 DOI: 10.1001/jamaneurol.2019.3762  0.32
2019 Noble W, Jimenez-Sanchez M, Perez-Nievas BG, Hanger DP. Considerations for future tau-targeted therapeutics: can they deliver? Expert Opinion On Drug Discovery. 1-3. PMID 31661994 DOI: 10.1080/17460441.2020.1685977  0.88
2019 Mauricio R, Benn C, Davis J, Dawson G, Dawson LA, Evans A, Fox N, Gallacher J, Hutton M, Isaac J, Jones DNC, Jones L, Lalli G, Libri V, Lovestone S, ... ... Noble W, et al. Tackling gaps in developing life-changing treatments for dementia. Alzheimer's & Dementia (New York, N. Y.). 5: 241-253. PMID 31297438 DOI: 10.1016/j.trci.2019.05.001  0.32
2019 Mórotz GM, Glennon EB, Gomez-Suaga P, Lau DHW, Robinson ED, Sedlák É, Vagnoni A, Noble W, Miller CCJ. LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains. Acta Neuropathologica Communications. 7: 73. PMID 31068217 DOI: 10.1186/s40478-019-0715-5  0.48
2019 Gómez-Suaga P, Pérez-Nievas BG, Glennon EB, Lau DHW, Paillusson S, Mórotz GM, Calì T, Pizzo P, Noble W, Miller CCJ. The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity. Acta Neuropathologica Communications. 7: 35. PMID 30841933 DOI: 10.1186/s40478-019-0688-4  0.48
2019 Guo T, Dakkak D, Rodriguez-Martin T, Noble W, Hanger DP. A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response. Acta Neuropathologica Communications. 7: 2. PMID 30606258 DOI: 10.1186/s40478-018-0651-9  0.88
2018 Lionnet A, Wade MA, Corbillé AG, Prigent A, Paillusson S, Tasselli M, Gonzales J, Durieu E, Rolli-Derkinderen M, Coron E, Duchalais E, Neunlist M, Perkinton MS, Hanger DP, Noble W, et al. Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy. Acta Neuropathologica Communications. 6: 65. PMID 30037345 DOI: 10.1186/s40478-018-0568-3  0.88
2018 Croft CL, Noble W. Preparation of organotypic brain slice cultures for the study of Alzheimer's disease. F1000research. 7: 592. PMID 29904599 DOI: 10.12688/f1000research.14500.1  0.52
2018 Giacomini C, Koo CY, Yankova N, Tavares IA, Wray S, Noble W, Hanger DP, Morris JDH. A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies. Acta Neuropathologica Communications. 6: 37. PMID 29730992 DOI: 10.1186/s40478-018-0539-8  0.92
2017 Croft CL, Kurbatskaya K, Hanger DP, Noble W. Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer's disease. Scientific Reports. 7: 7434. PMID 28785087 DOI: 10.1038/s41598-017-07906-1  0.88
2017 Guo T, Noble W, Hanger DP. Roles of tau protein in health and disease. Acta Neuropathologica. PMID 28386764 DOI: 10.1007/s00401-017-1707-9  0.88
2017 Paillusson S, Gomez-Suaga P, Stoica R, Little D, Gissen P, Devine MJ, Noble W, Hanger DP, Miller CC. α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca(2+) homeostasis and mitochondrial ATP production. Acta Neuropathologica. PMID 28337542 DOI: 10.1007/s00401-017-1704-z  0.88
2017 Croft CL, Wade MA, Kurbatskaya K, Mastrandreas P, Hughes MM, Phillips EC, Pooler AM, Perkinton MS, Hanger DP, Noble W. Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures. Cell Death & Disease. 8: e2671. PMID 28300838 DOI: 10.1038/cddis.2017.97  0.88
2017 Gomez-Suaga P, Paillusson S, Stoica R, Noble W, Hanger DP, Miller CC. The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy. Current Biology : Cb. PMID 28132811 DOI: 10.1016/j.cub.2016.12.038  0.88
2016 Stoica R, Paillusson S, Gomez-Suaga P, Mitchell JC, Lau DH, Gray EH, Sancho RM, Vizcay-Barrena G, De Vos KJ, Shaw CE, Hanger DP, Noble W, Miller CC. ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations. Embo Reports. PMID 27418313 DOI: 10.15252/embr.201541726  0.92
2016 Bondulich MK, Guo T, Meehan C, Manion J, Rodriguez Martin T, Mitchell JC, Hortobagyi T, Yankova N, Stygelbout V, Brion JP, Noble W, Hanger DP. Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate. Brain : a Journal of Neurology. PMID 27297240 DOI: 10.1093/brain/aww137  0.92
2016 Lau DH, Hogseth M, Phillips EC, O'Neill MJ, Pooler AM, Noble W, Hanger DP. Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease. Acta Neuropathologica Communications. 4: 49. PMID 27193083 DOI: 10.1186/s40478-016-0317-4  0.88
2016 Kurbatskaya K, Phillips EC, Croft CL, Dentoni G, Hughes MM, Wade MA, Al-Sarraj S, Troakes C, O'Neill MJ, Perez-Nievas BG, Hanger DP, Noble W. Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain. Acta Neuropathologica Communications. 4: 34. PMID 27036949 DOI: 10.1186/s40478-016-0299-2  0.88
2014 Phillips EC, Croft CL, Kurbatskaya K, O'Neill MJ, Hutton ML, Hanger DP, Garwood CJ, Noble W. Astrocytes and neuroinflammation in Alzheimer's disease. Biochemical Society Transactions. 42: 1321-5. PMID 25233410 DOI: 10.1042/BST20140155  0.92
2014 Hanger DP, Lau DH, Phillips EC, Bondulich MK, Guo T, Woodward BW, Pooler AM, Noble W. Intracellular and extracellular roles for tau in neurodegenerative disease. Journal of Alzheimer's Disease : Jad. 40: S37-45. PMID 24595196 DOI: 10.3233/JAD-132054  0.92
2014 Pooler AM, Noble W, Hanger DP. A role for tau at the synapse in Alzheimer's disease pathogenesis. Neuropharmacology. 76: 1-8. PMID 24076336 DOI: 10.1016/j.neuropharm.2013.09.018  0.92
2014 Atherton J, Kurbatskaya K, Bondulich M, Croft CL, Garwood CJ, Chhabra R, Wray S, Jeromin A, Hanger DP, Noble W. Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease. Aging Cell. 13: 49-59. PMID 23919677 DOI: 10.1111/acel.12148  0.92
2014 Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, Lin K, Breen G, Wroe R, To AW, Leroy K, ... ... Noble W, et al. Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Molecular Psychiatry. 19: 88-98. PMID 23164821 DOI: 10.1038/mp.2012.163  0.92
2013 Noble W, Hanger DP, Miller CC, Lovestone S. The importance of tau phosphorylation for neurodegenerative diseases. Frontiers in Neurology. 4: 83. PMID 23847585 DOI: 10.3389/fneur.2013.00083  0.92
2013 Vagnoni A, Glennon EB, Perkinton MS, Gray EH, Noble W, Miller CC. Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production. Human Molecular Genetics. 22: 4646-52. PMID 23825109 DOI: 10.1093/hmg/ddt313  0.92
2013 Rodríguez-Martín T, Cuchillo-Ibáñez I, Noble W, Nyenya F, Anderton BH, Hanger DP. Tau phosphorylation affects its axonal transport and degradation. Neurobiology of Aging. 34: 2146-57. PMID 23601672 DOI: 10.1016/j.neurobiolaging.2013.03.015  0.92
2013 Tavares IA, Touma D, Lynham S, Troakes C, Schober M, Causevic M, Garg R, Noble W, Killick R, Bodi I, Hanger DP, Morris JD. Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease. The Journal of Biological Chemistry. 288: 15418-29. PMID 23585562 DOI: 10.1074/jbc.M112.448183  0.92
2013 Pooler AM, Phillips EC, Lau DH, Noble W, Hanger DP. Physiological release of endogenous tau is stimulated by neuronal activity. Embo Reports. 14: 389-94. PMID 23412472 DOI: 10.1038/embor.2013.15  0.92
2012 Johnson R, Noble W, Tartaglia GG, Buckley NJ. Neurodegeneration as an RNA disorder. Progress in Neurobiology. 99: 293-315. PMID 23063563 DOI: 10.1016/j.pneurobio.2012.09.006  0.92
2012 Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC. Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production. Human Molecular Genetics. 21: 2845-54. PMID 22434822 DOI: 10.1093/hmg/dds109  0.92
2012 Pooler AM, Usardi A, Evans CJ, Philpott KL, Noble W, Hanger DP. Dynamic association of tau with neuronal membranes is regulated by phosphorylation. Neurobiology of Aging. 33: 431.e27-38. PMID 21388709 DOI: 10.1016/j.neurobiolaging.2011.01.005  0.92
2011 Noble W, Pooler AM, Hanger DP. Advances in tau-based drug discovery. Expert Opinion On Drug Discovery. 6: 797-810. PMID 22003359 DOI: 10.1517/17460441.2011.586690  0.92
2011 Hanger DP, Noble W. Functional implications of glycogen synthase kinase-3-mediated tau phosphorylation. International Journal of Alzheimer's Disease. 2011: 352805. PMID 21776376 DOI: 10.4061/2011/352805  0.92
2011 Usardi A, Pooler AM, Seereeram A, Reynolds CH, Derkinderen P, Anderton B, Hanger DP, Noble W, Williamson R. Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau. The Febs Journal. 278: 2927-37. PMID 21692989 DOI: 10.1111/j.1742-4658.2011.08218.x  0.92
2011 Garwood CJ, Pooler AM, Atherton J, Hanger DP, Noble W. Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture. Cell Death & Disease. 2: e167. PMID 21633390 DOI: 10.1038/cddis.2011.50  0.92
2010 Garwood CJ, Cooper JD, Hanger DP, Noble W. Anti-inflammatory impact of minocycline in a mouse model of tauopathy. Frontiers in Psychiatry. 1: 136. PMID 21423446 DOI: 10.3389/fpsyt.2010.00136  0.92
2010 Noble W, Burns MP. Challenges in neurodegeneration research. Frontiers in Psychiatry. 1: 7. PMID 21423419 DOI: 10.3389/fpsyt.2010.00007  0.92
2010 Noble W, Hanger DP, Gallo JM. Transgenic mouse models of tauopathy in drug discovery. Cns & Neurological Disorders Drug Targets. 9: 403-28. PMID 20522014  0.92
2009 Hanger DP, Seereeram A, Noble W. Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease. Expert Review of Neurotherapeutics. 9: 1647-66. PMID 19903024 DOI: 10.1586/ern.09.104  0.92
2009 Wray S, Noble W. Linking amyloid and tau pathology in Alzheimer's disease: the role of membrane cholesterol in Abeta-mediated tau toxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9665-7. PMID 19657019 DOI: 10.1523/JNEUROSCI.2234-09.2009  0.92
2009 Lebouvier T, Scales TM, Williamson R, Noble W, Duyckaerts C, Hanger DP, Reynolds CH, Anderton BH, Derkinderen P. The microtubule-associated protein tau is also phosphorylated on tyrosine. Journal of Alzheimer's Disease : Jad. 18: 1-9. PMID 19542604 DOI: 10.3233/JAD-2009-1116  0.92
2009 Noble W, Garwood CJ, Hanger DP. Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding. Prion. 3: 78-83. PMID 19458490  0.92
2009 Hanger DP, Anderton BH, Noble W. Tau phosphorylation: the therapeutic challenge for neurodegenerative disease. Trends in Molecular Medicine. 15: 112-9. PMID 19246243 DOI: 10.1016/j.molmed.2009.01.003  0.92
2009 Noble W, Garwood C, Stephenson J, Kinsey AM, Hanger DP, Anderton BH. Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 739-50. PMID 19001528 DOI: 10.1096/fj.08-113795  0.92
2007 Kelleher I, Garwood C, Hanger DP, Anderton BH, Noble W. Kinase activities increase during the development of tauopathy in htau mice. Journal of Neurochemistry. 103: 2256-67. PMID 17908241 DOI: 10.1111/j.1471-4159.2007.04930.x  0.92
2007 Cole AR, Noble W, van Aalten L, Plattner F, Meimaridou R, Hogan D, Taylor M, LaFrancois J, Gunn-Moore F, Verkhratsky A, Oddo S, LaFerla F, Giese KP, Dineley KT, Duff K, et al. Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. Journal of Neurochemistry. 103: 1132-44. PMID 17683481 DOI: 10.1111/j.1471-4159.2007.04829.x  0.92
2007 Gallo JM, Noble W, Martin TR. RNA and protein-dependent mechanisms in tauopathies: Consequences for therapeutic strategies Cellular and Molecular Life Sciences. 64: 1701-1714. PMID 17453144 DOI: 10.1007/s00018-007-6513-4  0.92
2005 Utton MA, Noble WJ, Hill JE, Anderton BH, Hanger DP. Molecular motors implicated in the axonal transport of tau and alpha-synuclein. Journal of Cell Science. 118: 4645-54. PMID 16176937 DOI: 10.1242/jcs.02558  0.92
2005 Derkinderen P, Scales TM, Hanger DP, Leung KY, Byers HL, Ward MA, Lenz C, Price C, Bird IN, Perera T, Kellie S, Williamson R, Noble W, Van Etten RA, Leroy K, et al. Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6584-93. PMID 16014719 DOI: 10.1523/JNEUROSCI.1487-05.2005  0.92
2005 Noble W, Planel E, Zehr C, Olm V, Meyerson J, Suleman F, Gaynor K, Wang L, LaFrancois J, Feinstein B, Burns M, Krishnamurthy P, Wen Y, Bhat R, Lewis J, et al. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 6990-5. PMID 15867159 DOI: 10.1073/pnas.0500466102  0.92
2003 Burns M, Gaynor K, Olm V, Mercken M, LaFrancois J, Wang L, Mathews PM, Noble W, Matsuoka Y, Duff K. Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5645-9. PMID 12843267  0.92
2003 Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J, Wang L, Kondo T, Davies P, Burns M, Veeranna, Nixon R, Dickson D, et al. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron. 38: 555-65. PMID 12765608 DOI: 10.1016/S0896-6273(03)00259-9  0.92
2003 Burns MP, Noble WJ, Olm V, Gaynor K, Casey E, LaFrancois J, Wang L, Duff K. Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques. Brain Research. Molecular Brain Research. 110: 119-25. PMID 12573540 DOI: 10.1016/S0169-328X(02)00647-2  0.92
2002 Duff K, Noble W, Gaynor K, Matsuoka Y. Organotypic slice cultures from transgenic mice as disease model systems. Journal of Molecular Neuroscience : Mn. 19: 317-20. PMID 12540058 DOI: 10.1385/JMN:19:3:317  0.92
2000 Nouri-Aria KT, O'Brien F, Noble W, Jabcobson MR, Rajakulasingam K, Durham SR. Cytokine expression during allergen-induced late nasal responses: IL-4 and IL-5 mRNA is expressed early (at 6 h) predominantly by eosinophils Clinical and Experimental Allergy. 30: 1709-1716. PMID 11122208 DOI: 10.1046/j.1365-2222.2000.00998.x  0.92
1999 Durham SR, Walker SM, Varga EM, Jacobson MR, O'Brien F, Noble W, Till SJ, Hamid QA, Nouri-Aria KT. Long-term clinical efficacy of grass-pollen immunotherapy. The New England Journal of Medicine. 341: 468-75. PMID 10441602 DOI: 10.1056/NEJM199908123410702  0.92
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