Jeremy J. Lambert, PhD - Publications

Affiliations: 
Neuroscience University of Dundee, Dundee, Scotland, United Kingdom 
Website:
http://medicine.dundee.ac.uk/staff-member/professor-jeremy-j-lambert

131 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Belelli D, Hales TG, Lambert JJ, Luscher B, Olsen R, Peters JA, Rudolph U, Sieghart W. GABA receptors in GtoPdb v.2021.3. Iuphar/Bps Guide to Pharmacology Cite. 2021. PMID 35005623 DOI: 10.2218/gtopdb/F72/2021.3  0.347
2020 Belelli D, Hogenkamp D, Gee KW, Lambert JJ. Realising the therapeutic potential of neuroactive steroid modulators of the GABA receptor. Neurobiology of Stress. 12: 100207. PMID 32435660 DOI: 10.1016/J.Ynstr.2019.100207  0.417
2019 Dixon CI, Walker SE, Swinny J, Belelli D, Lambert JJ, King SL, Stephens DN. Early-life stress influences acute and sensitized responses of adult mice to cocaine by interacting with GABAA α2 receptor expression. Behavioural Pharmacology. PMID 30724801 DOI: 10.1097/Fbp.0000000000000466  0.31
2018 Arnoux I, Willam M, Griesche N, Krummeich J, Watari H, Offermann N, Weber S, Narayan Dey P, Chen C, Monteiro O, Buettner S, Meyer K, Bano D, Radyushkin K, Langston R, ... Lambert JJ, et al. Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease. Elife. 7. PMID 30179155 DOI: 10.7554/Elife.38744  0.698
2018 Mitchell SJ, Maguire EP, Cunningham L, Gunn BG, Linke M, Zechner U, Dixon CI, King SL, Stephens DN, Swinny JD, Belelli D, Lambert JJ. Early-life adversity selectively impairs α2-GABA receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine. Neuropharmacology. PMID 30138693 DOI: 10.1016/J.Neuropharm.2018.08.021  0.336
2018 Sharp S, Mitchell SJ, Vallée M, Kuzmanova E, Cooper M, Belelli D, Lambert JJ, Huang JT. An isotope dilution based-targeted and non-targeted carbonyl neurosteroid/steroid profiling. Analytical Chemistry. PMID 29561593 DOI: 10.1021/Acs.Analchem.8B00055  0.302
2018 Monteiro O, Chen C, Bingham R, Argyrou A, Buxton R, Jönsson CP, Jones E, Bridges A, Gatfield K, Krauß S, Lambert J, Langston R, Schweiger S, Uings I. Pharmacological disruption of the MID1/a4 interaction reduces mutant Huntingtin levels in primary neuronal cultures. Neuroscience Letters. PMID 29499308 DOI: 10.1016/J.Neulet.2018.02.061  0.697
2018 Arnoux I, Willam M, Griesche N, Krummeich J, Watari H, Offermann N, Weber S, Dey PN, Chen C, Monteiro O, Buettner S, Meyer K, Bano D, Radyushkin K, Langston R, ... Lambert JJ, et al. Author response: Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease Elife. DOI: 10.7554/Elife.38744.032  0.685
2017 Weir CJ, Mitchell SJ, Lambert JJ. Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics. British Journal of Anaesthesia. 119: i167-i175. PMID 29161398 DOI: 10.1093/Bja/Aex369  0.407
2017 Belelli D, Brown AR, Mitchell SJ, Gunn BG, Herd MB, Phillips G, Seifi M, Swinny JD, Lambert JJ. Endogenous neurosteroids influence synaptic GABAA receptors during post-natal development. Journal of Neuroendocrinology. PMID 28905487 DOI: 10.1111/Jne.12537  0.392
2017 Etherington LA, Mihalik B, Pálvölgyi A, Ling I, Pallagi K, Kertész S, Varga P, Gunn BG, Brown AR, Livesey MR, Monteiro O, Belelli D, Barkóczy J, Spedding M, Gacsályi I, ... ... Lambert JJ, et al. Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent. Neuropharmacology. PMID 28807671 DOI: 10.1016/J.Neuropharm.2017.08.012  0.413
2016 Kumar N, Fagart J, Liere P, Mitchell SJ, Knibb AR, Petit-Topin I, Rame M, El-Etr M, Schumacher M, Lambert JJ, Rafestin-Oblin ME, Sitruk-Ware R. Nestorone® (NES) a Novel Progestin for Non-oral Contraception: Structure-activity Relationships and Brain Metabolism Studies. Endocrinology. en20161426. PMID 27824503 DOI: 10.1210/En.2016-1426  0.367
2016 Stephens DN, King SL, Lambert JJ, Belelli D, Duka T. GABAA Receptor Subtype Involvement in Addictive Behaviour. Genes, Brain, and Behavior. PMID 27539865 DOI: 10.1111/Gbb.12321  0.396
2015 Brown AR, Mitchell SJ, Peden DR, Herd MB, Seifi M, Swinny JD, Belelli D, Lambert JJ. During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons. Neuropharmacology. PMID 26626485 DOI: 10.1016/J.Neuropharm.2015.11.019  0.386
2015 Ling I, Mihalik B, Etherington LA, Kapus G, Pálvölgyi A, Gigler G, Kertész S, Gaál A, Pallagi K, Kiricsi P, Szabó É, Szénási G, Papp L, Hársing LG, Lévay G, ... ... Lambert JJ, et al. A novel GABAA alpha 5 receptor inhibitor with therapeutic potential. European Journal of Pharmacology. 764: 497-507. PMID 26169564 DOI: 10.1016/J.Ejphar.2015.07.005  0.421
2015 Brown AR, Herd MB, Belelli D, Lambert JJ. Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones. The Journal of Physiology. 593: 267-84. PMID 25556800 DOI: 10.1113/Jphysiol.2014.280263  0.424
2014 Seifi M, Brown JF, Mills J, Bhandari P, Belelli D, Lambert JJ, Rudolph U, Swinny JD. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 10361-78. PMID 25080596 DOI: 10.1523/Jneurosci.0441-14.2014  0.398
2014 Corteen NL, Carter JA, Rudolph U, Belelli D, Lambert JJ, Swinny JD. Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus. Brain Structure & Function. PMID 24973971 DOI: 10.1007/S00429-014-0824-7  0.417
2014 Herd MB, Lambert JJ, Belelli D. The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABAA receptor-mediated inhibition. The European Journal of Neuroscience. 40: 2487-501. PMID 24773078 DOI: 10.1111/Ejn.12601  0.386
2014 Golovko T, Min R, Lozovaya N, Falconer C, Yatsenko N, Tsintsadze T, Tsintsadze V, Ledent C, Harvey RJ, Belelli D, Lambert JJ, Rozov A, Burnashev N. Control of Inhibition by the Direct Action of Cannabinoids on GABAA Receptors. Cerebral Cortex (New York, N.Y. : 1991). PMID 24646614 DOI: 10.1093/Cercor/Bhu045  0.405
2014 Maguire EP, Macpherson T, Swinny JD, Dixon CI, Herd MB, Belelli D, Stephens DN, King SL, Lambert JJ. Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 823-38. PMID 24431441 DOI: 10.1523/Jneurosci.3232-13.2014  0.339
2014 Maguire EP, Mitchell EA, Greig SJ, Corteen N, Balfour DJ, Swinny JD, Lambert JJ, Belelli D. Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1232-44. PMID 24264816 DOI: 10.1038/Npp.2013.326  0.38
2013 Gunn BG, Cunningham L, Cooper MA, Corteen NL, Seifi M, Swinny JD, Lambert JJ, Belelli D. Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19534-54. PMID 24336719 DOI: 10.1523/Jneurosci.1337-13.2013  0.351
2013 Carland JE, Cooper MA, Livesey MR, Hales TG, Peters JA, Lambert JJ. Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor. The Journal of Biological Chemistry. 288: 31592-601. PMID 24030822 DOI: 10.1074/Jbc.M113.503300  0.408
2013 Herd MB, Brown AR, Lambert JJ, Belelli D. Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 14850-68. PMID 24027285 DOI: 10.1523/Jneurosci.1174-13.2013  0.423
2013 Baptista-Hon DT, Deeb TZ, Lambert JJ, Peters JA, Hales TG. The minimum M3-M4 loop length of neurotransmitter-activated pentameric receptors is critical for the structural integrity of cytoplasmic portals. The Journal of Biological Chemistry. 288: 21558-68. PMID 23740249 DOI: 10.1074/Jbc.M113.481689  0.334
2013 Newman AS, Batis N, Grafton G, Caputo F, Brady CA, Lambert JJ, Peters JA, Gordon J, Brain KL, Powell AD, Barnes NM. 5-Chloroindole: a potent allosteric modulator of the 5-HT₃ receptor. British Journal of Pharmacology. 169: 1228-38. PMID 23594147 DOI: 10.1111/Bph.12213  0.392
2013 Wlodarczyk AI, Sylantyev S, Herd MB, Kersanté F, Lambert JJ, Rusakov DA, Linthorst AC, Semyanov A, Belelli D, Pavlov I, Walker MC. GABA-independent GABAA receptor openings maintain tonic currents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 3905-14. PMID 23447601 DOI: 10.1523/Jneurosci.4193-12.2013  0.396
2013 Jensen ML, Wafford KA, Brown AR, Belelli D, Lambert JJ, Mirza NR. A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors. British Journal of Pharmacology. 168: 1118-32. PMID 23061935 DOI: 10.1111/Bph.12001  0.449
2013 Lambert J, Maguire E, Cunningham L, Mitchell S, Gunn B, Walker S, Claire D, King S, Jerome SS, Stephens D, Belelli D. S.6.3 - STRESS EXPOSURE DURING EARLY DEVELOPMENT ALTERS ACCUMBENS GABAA RECEPTOR FUNCTION IN ADULTHOOD AND RESULTS IN SENSITIZED RESPONSES TO COCAINE Behavioural Pharmacology. 24: e7. DOI: 10.1097/01.Fbp.0000434706.84012.1B  0.304
2011 Gunn BG, Brown AR, Lambert JJ, Belelli D. Neurosteroids and GABA(A) Receptor Interactions: A Focus on Stress. Frontiers in Neuroscience. 5: 131. PMID 22164129 DOI: 10.3389/Fnins.2011.00131  0.383
2011 Panzanelli P, Gunn BG, Schlatter MC, Benke D, Tyagarajan SK, Scheiffele P, Belelli D, Lambert JJ, Rudolph U, Fritschy JM. Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells. The Journal of Physiology. 589: 4959-80. PMID 21825022 DOI: 10.1113/Jphysiol.2011.216028  0.377
2011 Livesey MR, Cooper MA, Lambert JJ, Peters JA. Rings of charge within the extracellular vestibule influence ion permeation of the 5-HT3A receptor. The Journal of Biological Chemistry. 286: 16008-17. PMID 21454663 DOI: 10.1074/Jbc.M111.219618  0.332
2010 Dixon CI, Morris HV, Breen G, Desrivieres S, Jugurnauth S, Steiner RC, Vallada H, Guindalini C, Laranjeira R, Messas G, Rosahl TW, Atack JR, Peden DR, Belelli D, Lambert JJ, et al. Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors. Proceedings of the National Academy of Sciences of the United States of America. 107: 2289-94. PMID 20133874 DOI: 10.1073/Pnas.0910117107  0.435
2010 Peters JA, Cooper MA, Carland JE, Livesey MR, Hales TG, Lambert JJ. Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors. The Journal of Physiology. 588: 587-96. PMID 19933751 DOI: 10.1113/Jphysiol.2009.183137  0.33
2009 Lambert JJ, Cooper MA, Simmons RD, Weir CJ, Belelli D. Neurosteroids: endogenous allosteric modulators of GABA(A) receptors. Psychoneuroendocrinology. 34: S48-58. PMID 19758761 DOI: 10.1016/J.Psyneuen.2009.08.009  0.453
2009 Herd MB, Foister N, Chandra D, Peden DR, Homanics GE, Brown VJ, Balfour DJ, Lambert JJ, Belelli D. Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors. The European Journal of Neuroscience. 29: 1177-87. PMID 19302153 DOI: 10.1111/J.1460-9568.2009.06680.X  0.413
2009 Solovyova N, Moult PR, Milojkovic B, Lambert JJ, Harvey J. Bi-directional modulation of fast inhibitory synaptic transmission by leptin. Journal of Neurochemistry. 108: 190-201. PMID 19094063 DOI: 10.1111/J.1471-4159.2008.05751.X  0.359
2009 Carland JE, Cooper MA, Sugiharto S, Jeong HJ, Lewis TM, Barry PH, Peters JA, Lambert JJ, Moorhouse AJ. Characterization of the effects of charged residues in the intracellular loop on ion permeation in alpha1 glycine receptor channels. The Journal of Biological Chemistry. 284: 2023-30. PMID 19049967 DOI: 10.1074/Jbc.M806618200  0.401
2009 Wafford KA, van Niel MB, Ma QP, Horridge E, Herd MB, Peden DR, Belelli D, Lambert JJ. Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus. Neuropharmacology. 56: 182-9. PMID 18762200 DOI: 10.1016/J.Neuropharm.2008.08.004  0.471
2009 Stephens DN, Belelli D, Lambert JJ, Thomas H, King SL. Gaba(A) receptor subunits: their contribution to ethanol and other addictive behaviours in mice Alcoholism: Clinical and Experimental Research. 33. DOI: 10.1111/J.1530-0277.2009.00948.X  0.369
2008 Ahrens J, Leuwer M, Stachura S, Krampfl K, Belelli D, Lambert JJ, Haeseler G. A transmembrane residue influences the interaction of propofol with the strychnine-sensitive glycine alpha1 and alpha1beta receptor. Anesthesia and Analgesia. 107: 1875-83. PMID 19020133 DOI: 10.1213/Ane.0B013E3181875A31  0.446
2008 Livesey MR, Cooper MA, Deeb TZ, Carland JE, Kozuska J, Hales TG, Lambert JJ, Peters JA. Structural determinants of Ca2+ permeability and conduction in the human 5-hydroxytryptamine type 3A receptor. The Journal of Biological Chemistry. 283: 19301-13. PMID 18474595 DOI: 10.1074/Jbc.M802406200  0.34
2008 Herd MB, Haythornthwaite AR, Rosahl TW, Wafford KA, Homanics GE, Lambert JJ, Belelli D. The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells. The Journal of Physiology. 586: 989-1004. PMID 18079158 DOI: 10.1113/Jphysiol.2007.146746  0.397
2008 Peden DR, Petitjean CM, Herd MB, Durakoglugil MS, Rosahl TW, Wafford K, Homanics GE, Belelli D, Fritschy JM, Lambert JJ. Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones. The Journal of Physiology. 586: 965-87. PMID 18063661 DOI: 10.1113/Jphysiol.2007.145375  0.434
2008 Mitchell EA, Herd MB, Gunn BG, Lambert JJ, Belelli D. Neurosteroid modulation of GABAA receptors: molecular determinants and significance in health and disease. Neurochemistry International. 52: 588-95. PMID 18055067 DOI: 10.1016/J.Neuint.2007.10.007  0.466
2008 Simmons DR, Gillespie J, Weir CJ, Belelli D, Lambert JJ, Cooper M. A transmembrane amino acid determines neurosteroid modulation of strychnine-sensitive glycine receptors Bja: British Journal of Anaesthesia. 100. DOI: 10.1093/Bja/Aem397  0.362
2007 Deniau G, Slawin AM, Lebl T, Chorki F, Issberner JP, van Mourik T, Heygate JM, Lambert JJ, Etherington LA, Sillar KT, O'Hagan D. Synthesis, conformation and biological evaluation of the enantiomers of 3-fluoro-gamma-aminobutyric acid ((R)- and (S)-3F-GABA): an analogue of the neurotransmitter GABA. Chembiochem : a European Journal of Chemical Biology. 8: 2265-74. PMID 17990263 DOI: 10.1002/Cbic.200700371  0.353
2007 Herd MB, Belelli D, Lambert JJ. Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors. Pharmacology & Therapeutics. 116: 20-34. PMID 17531325 DOI: 10.1016/J.Pharmthera.2007.03.007  0.47
2007 Deeb TZ, Carland JE, Cooper MA, Livesey MR, Lambert JJ, Peters JA, Hales TG. Dynamic modification of a mutant cytoplasmic cysteine residue modulates the conductance of the human 5-HT3A receptor. The Journal of Biological Chemistry. 282: 6172-82. PMID 17200121 DOI: 10.1074/Jbc.M607698200  0.368
2006 Peters JA, Carland JE, Cooper MA, Livesey MR, Deeb TZ, Hales TG, Lambert JJ. Novel structural determinants of single-channel conductance in nicotinic acetylcholine and 5-hydroxytryptamine type-3 receptors. Biochemical Society Transactions. 34: 882-6. PMID 17052220 DOI: 10.1042/Bst0340882  0.404
2006 Magnaghi V, Ballabio M, Consoli A, Lambert JJ, Roglio I, Melcangi RC. GABA receptor-mediated effects in the peripheral nervous system: A cross-interaction with neuroactive steroids. Journal of Molecular Neuroscience : Mn. 28: 89-102. PMID 16632878 DOI: 10.1385/Jmn:28:1:89  0.426
2006 Hales TG, Dunlop JI, Deeb TZ, Carland JE, Kelley SP, Lambert JJ, Peters JA. Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 281: 8062-71. PMID 16407231 DOI: 10.1074/Jbc.M513222200  0.37
2006 Belelli D, Herd MB, Mitchell EA, Peden DR, Vardy AW, Gentet L, Lambert JJ. Neuroactive steroids and inhibitory neurotransmission: mechanisms of action and physiological relevance. Neuroscience. 138: 821-9. PMID 16310966 DOI: 10.1016/J.Neuroscience.2005.07.021  0.485
2006 Borghese CM, Stórustovu Sí, Ebert B, Herd MB, Belelli D, Lambert JJ, Marshall G, Wafford KA, Harris RA. The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol. The Journal of Pharmacology and Experimental Therapeutics. 316: 1360-8. PMID 16272217 DOI: 10.1124/Jpet.105.092452  0.373
2005 Belelli D, Peden DR, Rosahl TW, Wafford KA, Lambert JJ. Extrasynaptic GABAA receptors of thalamocortical neurons: a molecular target for hypnotics. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11513-20. PMID 16354909 DOI: 10.1523/Jneurosci.2679-05.2005  0.397
2005 Eisensamer B, Uhr M, Meyr S, Gimpl G, Deiml T, Rammes G, Lambert JJ, Zieglgänsberger W, Holsboer F, Rupprecht R. Antidepressants and antipsychotic drugs colocalize with 5-HT3 receptors in raft-like domains. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10198-206. PMID 16267227 DOI: 10.1523/Jneurosci.2460-05.2005  0.409
2005 Peters JA, Hales TG, Lambert JJ. Molecular determinants of single-channel conductance and ion selectivity in the Cys-loop family: insights from the 5-HT3 receptor. Trends in Pharmacological Sciences. 26: 587-94. PMID 16194573 DOI: 10.1016/J.Tips.2005.09.011  0.34
2005 Belelli D, Lambert JJ. Neurosteroids: endogenous regulators of the GABA(A) receptor. Nature Reviews. Neuroscience. 6: 565-75. PMID 15959466 DOI: 10.1038/Nrn1703  0.454
2004 Spruce BA, Campbell LA, McTavish N, Cooper MA, Appleyard MV, O'Neill M, Howie J, Samson J, Watt S, Murray K, McLean D, Leslie NR, Safrany ST, Ferguson MJ, Peters JA, ... ... Lambert JJ, et al. Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Research. 64: 4875-86. PMID 15256458 DOI: 10.1158/0008-5472.Can-03-3180  0.322
2004 Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ. The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance. Biochemical Society Transactions. 32: 547-52. PMID 15157181 DOI: 10.1042/Bst0320547  0.379
2004 Magnaghi V, Ballabio M, Cavarretta IT, Froestl W, Lambert JJ, Zucchi I, Melcangi RC. GABAB receptors in Schwann cells influence proliferation and myelin protein expression. The European Journal of Neuroscience. 19: 2641-9. PMID 15147298 DOI: 10.1111/J.0953-816X.2004.03368.X  0.399
2004 Weir CJ, Ling AT, Belelli D, Wildsmith JA, Peters JA, Lambert JJ. The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors. British Journal of Anaesthesia. 92: 704-11. PMID 15033889 DOI: 10.1093/Bja/Aeh125  0.461
2004 Caraiscos VB, Elliott EM, You-Ten KE, Cheng VY, Belelli D, Newell JG, Jackson MF, Lambert JJ, Rosahl TW, Wafford KA, MacDonald JF, Orser BA. Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proceedings of the National Academy of Sciences of the United States of America. 101: 3662-7. PMID 14993607 DOI: 10.1073/Pnas.0307231101  0.428
2003 Pau D, Belelli D, Callachan H, Peden DR, Dunlop JI, Peters JA, Guitart X, Gutierrez B, Lambert JJ. GABAA receptor modulation by the novel intravenous general anaesthetic E-6375. Neuropharmacology. 45: 1029-40. PMID 14614946 DOI: 10.1016/S0028-3908(03)00299-5  0.447
2003 Lambert JJ, Belelli D, Peden DR, Vardy AW, Peters JA. Neurosteroid modulation of GABAA receptors. Progress in Neurobiology. 71: 67-80. PMID 14611869 DOI: 10.1016/J.Pneurobio.2003.09.001  0.439
2003 Harney SC, Frenguelli BG, Lambert JJ. Phosphorylation influences neurosteroid modulation of synaptic GABAA receptors in rat CA1 and dentate gyrus neurones. Neuropharmacology. 45: 873-83. PMID 14529725 DOI: 10.1016/S0028-3908(03)00251-X  0.347
2003 Reynolds DS, Rosahl TW, Cirone J, O'Meara GF, Haythornthwaite A, Newman RJ, Myers J, Sur C, Howell O, Rutter AR, Atack J, Macaulay AJ, Hadingham KL, Hutson PH, Belelli D, ... Lambert JJ, et al. Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8608-17. PMID 13679430 DOI: 10.1523/Jneurosci.23-24-08608.2003  0.373
2003 Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA. A cytoplasmic region determines single-channel conductance in 5-HT3 receptors. Nature. 424: 321-4. PMID 12867984 DOI: 10.1038/Nature01788  0.375
2003 Belelli D, Muntoni AL, Merrywest SD, Gentet LJ, Casula A, Callachan H, Madau P, Gemmell DK, Hamilton NM, Lambert JJ, Sillar KT, Peters JA. The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia. Neuropharmacology. 45: 57-71. PMID 12814659 DOI: 10.1016/S0028-3908(03)00144-8  0.45
2002 Belelli D, Casula A, Ling A, Lambert JJ. The influence of subunit composition on the interaction of neurosteroids with GABA(A) receptors. Neuropharmacology. 43: 651-61. PMID 12367610 DOI: 10.1016/S0028-3908(02)00172-7  0.368
2002 Boyd GW, Low P, Dunlop JI, Robertson LA, Vardy A, Lambert JJ, Peters JA, Connolly CN. Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins. Molecular and Cellular Neurosciences. 21: 38-50. PMID 12359150 DOI: 10.1006/Mcne.2002.1160  0.406
2002 Lambert JJ, Belelli D. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors: commentary on Brown et al. British Journal of Pharmacology. 136: 957-9. PMID 12145094 DOI: 10.1038/Sj.Bjp.0704796  0.421
2001 Lambert JJ, Belelli D, Harney SC, Peters JA, Frenguelli BG. Modulation of native and recombinant GABA(A) receptors by endogenous and synthetic neuroactive steroids. Brain Research. Brain Research Reviews. 37: 68-80. PMID 11744075 DOI: 10.1016/S0165-0173(01)00124-2  0.467
2001 Anderson A, Belelli D, Bennett DJ, Buchanan KI, Casula A, Cooke A, Feilden H, Gemmell DK, Hamilton NM, Hutchinson EJ, Lambert JJ, Maidment MS, McGuire R, McPhail P, Miller S, et al. Alpha-amino acid phenolic ester derivatives: novel water-soluble general anesthetic agents which allosterically modulate GABA(A) receptors. Journal of Medicinal Chemistry. 44: 3582-91. PMID 11606122 DOI: 10.1021/Jm010903I  0.389
2001 Lambert JJ, Harney SC, Belelli D, Peters JA. Neurosteroid modulation of recombinant and synaptic GABAA receptors. International Review of Neurobiology. 46: 177-205. PMID 11599300 DOI: 10.1016/S0074-7742(01)46063-6  0.457
2001 Rego AC, Lambert JJ, Nicholls DG. Developmental profile of excitatory GABA(A) responses in cultured rat cerebellar granule cells. Neuroreport. 12: 477-82. PMID 11234749 DOI: 10.1097/00001756-200103050-00011  0.397
2001 Lambert JJ, Peters JA, Harney SC, Belelli D. Steroid Modulation of GABAA Receptors Handbook of Experimental Pharmacology. 150: 117-140. DOI: 10.1007/978-3-642-56833-6_4  0.337
2000 Gunthorpe MJ, Peters JA, Gill CH, Lambert JJ, Lummis SC. The 4'lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-HT3A receptors. The Journal of Physiology. 522: 187-98. PMID 10639097 DOI: 10.1111/J.1469-7793.2000.00187.X  0.431
1999 Belelli D, Pistis M, Peters JA, Lambert JJ. General anaesthetic action at transmitter-gated inhibitory amino acid receptors. Trends in Pharmacological Sciences. 20: 496-502. PMID 10603492 DOI: 10.1016/S0165-6147(99)01405-4  0.413
1999 Belelli D, Pau D, Cabras G, Peters JA, Lambert JJ. A single amino acid confers barbiturate sensitivity upon the GABA rho 1 receptor. British Journal of Pharmacology. 127: 601-4. PMID 10401548 DOI: 10.1038/Sj.Bjp.0702611  0.476
1999 Belelli D, Pistis M, Peters JA, Lambert JJ. The interaction of general anaesthetics and neurosteroids with GABA(A) and glycine receptors. Neurochemistry International. 34: 447-52. PMID 10397373 DOI: 10.1016/S0197-0186(99)00037-6  0.447
1999 Hope AG, Belelli D, Mair ID, Lambert JJ, Peters JA. Molecular determinants of (+)-tubocurarine binding at recombinant 5-hydroxytryptamine3A receptor subunits. Molecular Pharmacology. 55: 1037-43. PMID 10347245 DOI: 10.1124/Mol.55.6.1037  0.41
1999 Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF. The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature. 397: 359-63. PMID 9950429 DOI: 10.1038/16941  0.426
1999 Pistis M, Belelli D, McGurk K, Peters JA, Lambert JJ. Complementary regulation of anaesthetic activation of human (alpha6beta3gamma2L) and Drosophila (RDL) GABA receptors by a single amino acid residue. The Journal of Physiology. 515: 3-18. PMID 9925873 DOI: 10.1111/J.1469-7793.1999.003Ad.X  0.465
1998 Mair ID, Lambert JJ, Yang J, Dempster J, Peters JA. Pharmacological characterization of a rat 5-hydroxytryptamine type3 receptor subunit (r5-HT3A(b)) expressed in Xenopus laevis oocytes. British Journal of Pharmacology. 124: 1667-74. PMID 9756382 DOI: 10.1038/Sj.Bjp.0702037  0.333
1998 McGurk KA, Pistis M, Belelli D, Hope AG, Lambert JJ. The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor. British Journal of Pharmacology. 124: 13-20. PMID 9630337 DOI: 10.1038/Sj.Bjp.0701787  0.441
1998 Brown AM, Hope AG, Lambert JJ, Peters JA. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). The Journal of Physiology. 507: 653-65. PMID 9508827 DOI: 10.1111/J.1469-7793.1998.653Bs.X  0.337
1997 Pistis M, Belelli D, Peters JA, Lambert JJ. The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study. British Journal of Pharmacology. 122: 1707-19. PMID 9422818 DOI: 10.1038/Sj.Bjp.0701563  0.422
1997 Belelli D, Lambert JJ, Peters JA, Wafford K, Whiting PJ. The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid. Proceedings of the National Academy of Sciences of the United States of America. 94: 11031-6. PMID 9380754 DOI: 10.1073/Pnas.94.20.11031  0.393
1997 Anderson A, Boyd AC, Byford A, Campbell AC, Gemmell DK, Hamilton NM, Hill DR, Hill-Venning C, Lambert JJ, Maidment MS, May V, Marshall RJ, Peters JA, Rees DC, Stevenson D, et al. Anesthetic activity of novel water-soluble 2 beta-morpholinyl steroids and their modulatory effects at GABAA receptors. Journal of Medicinal Chemistry. 40: 1668-81. PMID 9171876 DOI: 10.1021/Jm960733N  0.311
1997 Hill-Venning C, Belelli D, Peters JA, Lambert JJ. Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor. British Journal of Pharmacology. 120: 749-56. PMID 9138677 DOI: 10.1038/Sj.Bjp.0700927  0.42
1996 Belelli D, Lambert JJ, Peters JA, Gee KW, Lan NC. Modulation of human recombinant GABAA receptors by pregnanediols. Neuropharmacology. 35: 1223-31. PMID 9014137 DOI: 10.1016/S0028-3908(96)00066-4  0.319
1996 Hill-Venning C, Peters JA, Callachan H, Lambert JJ, Gemmell DK, Anderson A, Byford A, Hamilton N, Hill DR, Marshall RJ, Campbell AC. The anaesthetic action and modulation of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology. 35: 1209-22. PMID 9014136 DOI: 10.1016/S0028-3908(96)00069-X  0.443
1996 Hope AG, Peters JA, Brown AM, Lambert JJ, Blackburn TP. Characterization of a human 5-hydroxytryptamine3 receptor type A (h5-HT3R-AS) subunit stably expressed in HEK 293 cells. British Journal of Pharmacology. 118: 1237-45. PMID 8818349 DOI: 10.1111/J.1476-5381.1996.Tb15529.X  0.401
1996 Belelli D, Callachan H, Hill-Venning C, Peters JA, Lambert JJ. Interaction of positive allosteric modulators with human and Drosophila recombinant GABA receptors expressed in Xenopus laevis oocytes. British Journal of Pharmacology. 118: 563-76. PMID 8762079 DOI: 10.1111/J.1476-5381.1996.Tb15439.X  0.434
1996 Lambert JJ, Belelli D, Hill-Venning C, Callachan H, Peters JA. Neurosteroid modulation of native and recombinant GABAA receptors. Cellular and Molecular Neurobiology. 16: 155-74. PMID 8743967 DOI: 10.1007/Bf02088174  0.342
1995 Belelli D, Balcarek JM, Hope AG, Peters JA, Lambert JJ, Blackburn TP. Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit. Molecular Pharmacology. 48: 1054-62. PMID 8848005  0.301
1995 Halliwell RF, Davey PG, Lambert JJ. A patch clamp study of the effects of ciprofloxacin and biphenyl acetic acid on rat hippocampal neurone GABAA and ionotropic glutamate receptors. Neuropharmacology. 34: 1615-24. PMID 8788959 DOI: 10.1016/0028-3908(95)00106-9  0.322
1995 Gill CH, Peters JA, Lambert JJ. An electrophysiological investigation of the properties of a murine recombinant 5-HT3 receptor stably expressed in HEK 293 cells. British Journal of Pharmacology. 114: 1211-21. PMID 7620711 DOI: 10.1111/J.1476-5381.1995.Tb13335.X  0.357
1995 Downie DL, Hope AG, Belelli D, Lambert JJ, Peters JA, Bentley KR, Steward LJ, Chen CY, Barnes NM. The interaction of trichloroethanol with murine recombinant 5-HT3 receptors. British Journal of Pharmacology. 114: 1641-51. PMID 7541281 DOI: 10.1111/J.1476-5381.1995.Tb14952.X  0.368
1995 Lambert JJ, Belelli D, Hill-Venning C, Peters JA. Neurosteroids and GABAA receptor function. Trends in Pharmacological Sciences. 16: 295-303. PMID 7482994 DOI: 10.1016/S0165-6147(00)89058-6  0.448
1995 Hope AG, Brawn AM, Peters JA, Lambert JJ, Balcarek JM, Blackburn TP. Characterization of a cloned human 5-hydroxytryptamine-type 3 receptor subunit stably expressed in HEK 293 cells: 30.3 Behavioural Pharmacology. 6: 147. DOI: 10.1097/00008877-199505001-00175  0.369
1995 Belelli D, Hope AG, Peters JA, Lambert JJ, Blackburn TP, Balcarek JM. Functional properties of a human recombinant 5-hydroxytryptamine-type 3 receptor expressed in Xenopus laevis oocytes Behavioural Pharmacology. 6: 145. DOI: 10.1097/00008877-199505001-00173  0.345
1994 Chen R, Belelli D, Lambert JJ, Peters JA, Reyes A, Lan NC. Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor. Proceedings of the National Academy of Sciences of the United States of America. 91: 6069-73. PMID 8016117 DOI: 10.1073/Pnas.91.13.6069  0.444
1994 Downie DL, Hope AG, Lambert JJ, Peters JA, Blackburn TP, Jones BJ. Pharmacological characterization of the apparent splice variants of the murine 5-HT3 R-A subunit expressed in Xenopus laevis oocytes. Neuropharmacology. 33: 473-82. PMID 7984286 DOI: 10.1016/0028-3908(94)90078-7  0.35
1993 Peters JA, Malone HM, Lambert JJ. An electrophysiological investigation of the properties of 5-HT3 receptors of rabbit nodose ganglion neurones in culture. British Journal of Pharmacology. 110: 665-76. PMID 7694755 DOI: 10.1111/J.1476-5381.1993.Tb13863.X  0.318
1993 Hope AG, Downie DL, Sutherland L, Lambert JJ, Peters JA, Burchell B. Cloning and functional expression of an apparent splice variant of the murine 5-HT3 receptor A subunit. European Journal of Pharmacology. 245: 187-92. PMID 7683998 DOI: 10.1016/0922-4106(93)90128-V  0.392
1992 Nooney JM, Lambert JJ, Chiappinelli VA. The interaction of kappa-bungarotoxin with the nicotinic receptor of bovine chromaffin cells. Brain Research. 573: 77-82. PMID 1576536 DOI: 10.1016/0006-8993(92)90115-P  0.339
1992 Peters JA, Malone HM, Lambert JJ. Recent advances in the electrophysiological characterization of 5-HT3 receptors. Trends in Pharmacological Sciences. 13: 391-7. PMID 1413088 DOI: 10.1016/0165-6147(92)90119-Q  0.393
1992 Hales TG, Lambert JJ. Modulation of GABAA and glycine receptors by chlormethiazole. European Journal of Pharmacology. 210: 239-46. PMID 1319334 DOI: 10.1016/0014-2999(92)90410-6  0.441
1992 Nooney JM, Peters JA, Lambert JJ. A patch clamp study of the nicotinic acetylcholine receptor of bovine adrenomedullary chromaffin cells in culture. The Journal of Physiology. 455: 503-27. PMID 1282932 DOI: 10.1113/Jphysiol.1992.Sp019314  0.34
1991 Peters JA, Malone HM, Lambert JJ. Ketamine potentiates 5-HT3 receptor-mediated currents in rabbit nodose ganglion neurones. British Journal of Pharmacology. 103: 1623-5. PMID 1718520 DOI: 10.1111/J.1476-5381.1991.Tb09837.X  0.39
1991 Malone HM, Peters JA, Lambert JJ. Physiological and pharmacological properties of 5-HT3 receptors--a patch clamp-study. Neuropeptides. 19: 25-30. PMID 1715528 DOI: 10.1016/0143-4179(91)90080-3  0.363
1991 Hales TG, Lambert JJ. The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones. British Journal of Pharmacology. 104: 619-28. PMID 1665745 DOI: 10.1111/J.1476-5381.1991.Tb12479.X  0.417
1991 Halliwell RF, Davey PG, Lambert JJ. The effects of quinolones and NSAIDs upon GABA-evoked currents recorded from rat dorsal root ganglion neurones. The Journal of Antimicrobial Chemotherapy. 27: 209-18. PMID 1647389 DOI: 10.1093/jac/27.2.209  0.313
1991 Hales TG, Lambert JJ. MODULATION OF THE GABAA RECEPTOR BY PROPOFOL Anesthesiology. 75: A587. DOI: 10.1097/00000542-199109001-00586  0.407
1990 Courtney MJ, Lambert JJ, Nicholls DG. Glutamate-receptor-mediated regulation of the cytoplasmic free calcium level in cultured cerebellar granule cells. Biochemical Society Transactions. 18: 420-1. PMID 2164986 DOI: 10.1042/Bst0180420  0.363
1990 Courtney MJ, Lambert JJ, Nicholls DG. The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 3873-9. PMID 1980131 DOI: 10.1523/Jneurosci.10-12-03873.1990  0.345
1990 Lambert JJ, Peters JA, Sturgess NC, Hales TG. Steroid modulation of the GABAA receptor complex: electrophysiological studies. Ciba Foundation Symposium. 153: 56-71; discussion 71. PMID 1963400 DOI: 10.1002/9780470513989.ch4  0.365
1990 Peters JA, Malone HM, Lambert JJ. Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neuroscience Letters. 110: 107-12. PMID 1691468 DOI: 10.1016/0304-3940(90)90796-C  0.355
1990 Peters JA, Malone HM, Lambert JJ. 5-Hydroxytryptamine3 receptor mediated responses on adult rabbit nodose ganglion neurones in cell culture European Journal of Pharmacology. 183: 1112. DOI: 10.1016/0014-2999(90)92980-W  0.349
1989 Lambert JJ, Peters JA, Hales TG, Dempster J. The properties of 5-HT3 receptors in clonal cell lines studied by patch-clamp techniques. British Journal of Pharmacology. 97: 27-40. PMID 2720311 DOI: 10.1111/J.1476-5381.1989.Tb11920.X  0.319
1989 Peters JA, Lambert JJ. Electrophysiology of 5-HT3 receptors in neuronal cell lines. Trends in Pharmacological Sciences. 10: 172-5. PMID 2667222 DOI: 10.1016/0165-6147(89)90230-7  0.364
1989 Halliwell RF, Peters JA, Lambert JJ. The mechanism of action and pharmacological specificity of the anticonvulsant NMDA antagonist MK-801: a voltage clamp study on neuronal cells in culture. British Journal of Pharmacology. 96: 480-94. PMID 2647206 DOI: 10.1111/J.1476-5381.1989.Tb11841.X  0.378
1989 Peters JA, Lambert JJ, Cottrell GA. An electrophysiological investigation of the characteristics and function of GABAA receptors on bovine adrenomedullary chromaffin cells. Pflã¼Gers Archiv : European Journal of Physiology. 415: 95-103. PMID 2560166 DOI: 10.1007/Bf00373146  0.447
1988 Peters JA, Kirkness EF, Callachan H, Lambert JJ, Turner AJ. Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids. British Journal of Pharmacology. 94: 1257-69. PMID 2850060 DOI: 10.1111/J.1476-5381.1988.Tb11646.X  0.388
1988 Peters JA, Hales TG, Lambert JJ. Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells. European Journal of Pharmacology. 151: 491-5. PMID 2463926 DOI: 10.1016/0014-2999(88)90550-X  0.366
1987 Cottrell GA, Lambert JJ, Peters JA. Modulation of GABAA receptor activity by alphaxalone. British Journal of Pharmacology. 90: 491-500. PMID 3032320 DOI: 10.1111/J.1476-5381.1987.Tb11198.X  0.414
1987 Callachan H, Cottrell GA, Hather NY, Lambert JJ, Nooney JM, Peters JA. Modulation of the GABAA receptor by progesterone metabolites. Proceedings of the Royal Society of London. Series B, Biological Sciences. 231: 359-69. PMID 2888123 DOI: 10.1098/Rspb.1987.0049  0.406
1987 Lambert JJ, Peters JA, Cottrell GA. Actions of synthetic and endogenous steroids on the GABAA receptor Trends in Pharmacological Sciences. 8: 224-227. DOI: 10.1016/0165-6147(87)90067-8  0.44
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