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Timothy Y. Huang, Ph.D. - Publications

Affiliations: 
2004 University of Calgary, Calgary, Alberta, Canada 
Area:
Molecular Biology
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Zhang D, Zhang W, Ming C, Gao X, Yuan H, Lin X, Mao X, Wang C, Guo X, Du Y, Shao L, Yang R, Lin Z, Wu X, Huang TY, et al. P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy. Neuron. PMID 38513667 DOI: 10.1016/j.neuron.2024.02.017  0.58
2023 Cui Q, Liang S, Li H, Guo Y, Lv J, Wang X, Qin P, Xu H, Huang TY, Lu Y, Tian Q, Zhang T. SNX17 Mediates Dendritic Spine Maturation via p140Cap. Molecular Neurobiology. PMID 37704928 DOI: 10.1007/s12035-023-03620-4  0.512
2023 Zhao Y, Zheng Q, Hong Y, Gao Y, Hu J, Lang M, Zhang H, Zhou Y, Luo H, Zhang X, Sun H, Yan XX, Huang TY, Wang YJ, Xu H, et al. β-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice. Nature Neuroscience. PMID 37264159 DOI: 10.1038/s41593-023-01352-1  0.591
2023 Gao Y, Hong Y, Huang L, Zheng S, Zhang H, Wang S, Yao Y, Zhao Y, Zhu L, Xu Q, Chai X, Zeng Y, Zeng Y, Zheng L, Zhou Y, ... ... Huang TY, et al. β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function. Cell. 186: 1026-1038.e20. PMID 36868208 DOI: 10.1016/j.cell.2023.01.021  0.459
2022 Zhu B, Liu Y, Hwang S, Archuleta K, Huang H, Campos A, Murad R, Piña-Crespo J, Xu H, Huang TY. Trem2 deletion enhances tau dispersion and pathology through microglia exosomes. Molecular Neurodegeneration. 17: 58. PMID 36056435 DOI: 10.1186/s13024-022-00562-8  0.589
2022 Zhao P, Xu Y, Jiang LL, Fan X, Ku Z, Li L, Liu X, Deng M, Arase H, Zhu JJ, Huang TY, Zhao Y, Zhang C, Xu H, Tong Q, et al. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Molecular Neurodegeneration. 17: 44. PMID 35717259 DOI: 10.1186/s13024-022-00550-y  0.713
2022 Zheng Q, Song B, Li G, Cai F, Wu M, Zhao Y, Jiang L, Guo T, Shen M, Hou H, Zhou Y, Zhao Y, Di A, Zhang L, Zeng F, ... ... Huang TY, et al. USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Aβ generation. The Journal of Clinical Investigation. 132. PMID 35229730 DOI: 10.1172/JCI152170  0.729
2021 Xu P, Chang JC, Zhou X, Wang W, Bamkole M, Wong E, Bettayeb K, Jiang LL, Huang T, Luo W, Xu H, Nairn AC, Flajolet M, Ip NY, Li YM, et al. GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. The Journal of Experimental Medicine. 218. PMID 34156424 DOI: 10.1084/jem.20202446  0.749
2020 Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li X, Jiang L, Hodges AP, Rosenthal SB, Zhou L, Yancey J, McQuade A, Blurton-Jones M, Tanzi RE, Huang TY, et al. Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE. The Journal of Experimental Medicine. 217. PMID 32941599 DOI: 10.1084/Jem.20200474  0.741
2020 Zhao D, Zhou Y, Huo Y, Meng J, Xiao X, Han L, Zhang X, Luo H, Can D, Sun H, Huang TY, Wang X, Zhang J, Liu FR, Xu H, et al. RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation. Cell Death and Differentiation. PMID 32908202 DOI: 10.1038/S41418-020-00620-Y  0.53
2020 Guo T, Zhang D, Zeng Y, Huang TY, Xu H, Zhao Y. Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease. Molecular Neurodegeneration. 15: 40. PMID 32677986 DOI: 10.1186/S13024-020-00391-7  0.592
2020 Stupack J, Xiong XP, Jiang LL, Zhang T, Zhou L, Campos A, Ranscht B, Mobley W, Pasquale EB, Xu H, Huang TY. Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32601248 DOI: 10.1523/Jneurosci.0723-20.2020  0.621
2019 Zhou J, Chow HM, Liu Y, Wu D, Shi M, Li J, Wen L, Gao Y, Chen G, Zhuang K, Lin H, Zhang G, Xie W, Li H, Leng L, ... ... Huang TY, et al. Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover. Biological Psychiatry. PMID 31955914 DOI: 10.1016/J.Biopsych.2019.11.013  0.53
2019 Zeng F, Ma X, Zhu L, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, ... ... Huang T, et al. The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability. Plos Biology. 17: e3000525. PMID 31841517 DOI: 10.1371/Journal.Pbio.3000525  0.504
2019 Zhang C, Tan Z, Xie Y, Zhao Y, Huang TY, Lu Z, Luo H, Can D, Xu H, Zhang YW, Zhang X. Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway. Frontiers in Aging Neuroscience. 11: 243. PMID 31551758 DOI: 10.3389/Fnagi.2019.00243  0.484
2019 Xie Y, Niu M, Ji C, Huang TY, Zhang C, Tian Y, Shi Z, Wang C, Zhao Y, Luo H, Can D, Xu H, Zhang YW, Zhang X. SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse. Frontiers in Cellular Neuroscience. 13: 410. PMID 31551717 DOI: 10.3389/Fncel.2019.00410  0.605
2019 Huang TY, Xu H. Bringing Order out of Chaos: Establishing an Epistatic Relationship between CD33 and TREM2. Neuron. 103: 747-749. PMID 31487521 DOI: 10.1016/J.Neuron.2019.08.019  0.47
2019 Jiang LL, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez MJ, Yu H, Cleveland DW, Ravits J, Da Cruz S, Long T, Huang TY, et al. Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment. The Journal of Clinical Investigation. 130. PMID 31112137 DOI: 10.1172/Jci127695  0.676
2018 Li H, Liu CC, Zheng H, Huang TY. Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer's disease -conformist, nonconformist, and realistic prospects for AD pathogenesis. Translational Neurodegeneration. 7: 34. PMID 30603085 DOI: 10.1186/s40035-018-0139-3  0.347
2018 Zhao D, Meng J, Zhao Y, Huo Y, Liu Y, Zheng N, Zhang M, Gao Y, Chen Z, Sun H, Wang X, Jing C, Zhang T, Zhang X, Luo H, ... ... Huang TY, et al. RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits. Biological Psychiatry. PMID 30292394 DOI: 10.1016/J.Biopsych.2018.08.009  0.531
2018 Zhang X, Huang TY, Yancey J, Luo H, Zhang Y. The Role of Rab GTPases in Alzheimer's Disease. Acs Chemical Neuroscience. PMID 30261139 DOI: 10.1021/Acschemneuro.8B00387  0.446
2018 Leng L, Zhuang K, Liu Z, Huang C, Gao Y, Chen G, Lin H, Hu Y, Wu D, Shi M, Xie W, Sun H, Shao Z, Li H, Zhang K, ... ... Huang TY, et al. Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation. Neuron. PMID 30220511 DOI: 10.1016/J.Neuron.2018.08.031  0.438
2018 Zhuang K, Huang C, Leng L, Zheng H, Gao Y, Chen G, Ji Z, Sun H, Hu Y, Wu D, Shi M, Li H, Zhao Y, Zhang Y, Xue M, ... ... Huang TY, et al. Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression. Cell Reports. 24: 701-712. PMID 30021166 DOI: 10.1016/J.Celrep.2018.06.055  0.468
2018 Du Y, Zhao Y, Li C, Zheng Q, Tian J, Li Z, Huang TY, Zhang W, Xu H. Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes. The Journal of Experimental Medicine. PMID 29739836 DOI: 10.1084/Jem.20171193  0.626
2018 Zhang H, Huang T, Hong Y, Yang W, Zhang X, Luo H, Xu H, Wang X. The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases. Frontiers in Aging Neuroscience. 10: 79. PMID 29632483 DOI: 10.3389/Fnagi.2018.00079  0.591
2018 Zhao Y, Wu X, Li X, Jiang LL, Gui X, Liu Y, Sun Y, Zhu B, Piña-Crespo JC, Zhang M, Zhang N, Chen X, Bu G, An Z, Huang TY, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 97: 1023-1031.e7. PMID 29518356 DOI: 10.1016/J.Neuron.2018.01.031  0.772
2017 Zhao Y, Li X, Huang T, Jiang LL, Tan Z, Zhang M, Cheng IH, Wang X, Bu G, Zhang YW, Wang Q, Xu H. Intracellular trafficking of TREM2 is regulated by presenilin 1. Experimental & Molecular Medicine. 49: e405. PMID 29611543 DOI: 10.1038/Emm.2017.200  0.764
2017 Zhu B, Jiang L, Huang T, Zhao Y, Liu T, Zhong Y, Li X, Campos A, Pomeroy K, Masliah E, Zhang D, Xu H. ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating γ-secretase activity. Nature Communications. 8: 1472. PMID 29133892 DOI: 10.1038/S41467-017-01799-4  0.76
2017 Huang TY, Zhao Y, Jiang LL, Li X, Liu Y, Sun Y, Piña-Crespo JC, Zhu B, Masliah E, Willnow TE, Pasquale EB, Xu H. SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration. The Journal of Experimental Medicine. PMID 29114064 DOI: 10.1084/Jem.20171413  0.783
2016 Zheng Q, Huang T, Zhang L, Zhou Y, Luo H, Xu H, Wang X. Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases. Frontiers in Aging Neuroscience. 8: 303. PMID 28018215 DOI: 10.3389/Fnagi.2016.00303  0.496
2016 Wang X, Zhou Y, Wang J, Tseng IC, Huang T, Zhao Y, Zheng Q, Gao Y, Luo H, Zhang X, Bu G, Hong W, Xu H. SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 12586-12597. PMID 27974614 DOI: 10.1523/Jneurosci.1620-16.2016  0.499
2016 Huang TY, Zhao Y, Li X, Wang X, Tseng IC, Thompson R, Tu S, Willnow TE, Zhang YW, Xu H. SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7996-8011. PMID 27466343 DOI: 10.1523/Jneurosci.0206-16.2016  0.662
2016 Yan L, Chen Y, Li W, Huang X, Badie H, Jian F, Huang T, Zhao Y, Cohen SN, Li L, Zhang YW, Luo H, Tu S, Xu H. RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits. Scientific Reports. 6: 18668. PMID 26733416 DOI: 10.1038/Srep18668  0.583
2015 Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, et al. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 87: 963-75. PMID 26335643 DOI: 10.1016/J.Neuron.2015.08.020  0.532
2014 Wang X, Huang T, Zhao Y, Zheng Q, Thompson RC, Bu G, Zhang YW, Hong W, Xu H. Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity. Cell Reports. 9: 1023-33. PMID 25437557 DOI: 10.1016/J.Celrep.2014.09.037  0.626
2014 Wang X, Huang T, Bu G, Xu H. Dysregulation of protein trafficking in neurodegeneration. Molecular Neurodegeneration. 9: 31. PMID 25152012 DOI: 10.1186/1750-1326-9-31  0.595
2013 Huang TY, Michael S, Xu T, Sarkeshik A, Moresco JJ, Yates JR, Masliah E, Bokoch GM, DerMardirossian C. A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation. Molecular Biology of the Cell. 24: 194-209. PMID 23223568 DOI: 10.1091/Mbc.E12-07-0565  0.331
2005 Huang TY, Renaud-Young M, Young D. Nak1 interacts with Hob1 and Wsp1 to regulate cell growth and polarity in Schizosaccharomyces pombe. Journal of Cell Science. 118: 199-210. PMID 15615784 DOI: 10.1242/Jcs.01608  0.686
2003 Huang TY, Markley NA, Young D. Nak1, an essential germinal center (GC) kinase regulates cell morphology and growth in Schizosaccharomyces pombe. The Journal of Biological Chemistry. 278: 991-7. PMID 12427731 DOI: 10.1074/Jbc.M208993200  0.709
2002 Meijer M, Karimi-Busheri F, Huang TY, Weinfeld M, Young D. Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombe. The Journal of Biological Chemistry. 277: 4050-5. PMID 11729194 DOI: 10.1074/jbc.M109383200  0.658
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