Raymond Chuen-Chung Chang, PhD - Related publications

Anatomy The University of Hong Kong, San Francisco, Hong Kong Island, Hong Kong 
Neuroscience, neuroimmunology, neurodegeneration, Alzheimer's disease, Parkinson's disease, glaucoma, herbal medicine, depression, neuroinflammation
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Ai J, Wang H, Chu P, Shopit A, Niu M, Ahmad N, Tesfaldet T, Wang FH, Fang JN, Li X, Tang SJ, Qing Ju Han, Han G, Peng J, Tang Z. The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro. Free Radical Biology & Medicine. PMID 33131696 DOI: 10.1016/j.freeradbiomed.2020.10.003   
2020 Calvo-Rodriguez M, García-Rodríguez C, Villalobos C, Núñez L. Role of Toll Like Receptor 4 in Alzheimer's Disease. Frontiers in Immunology. 11: 1588. PMID 32983082 DOI: 10.3389/fimmu.2020.01588   
2020 Saleh SR, Abdelhady SA, Khattab AR, El-Hadidy WF. Dual Prophylactic/Therapeutic Potential of Date Seed, and Nigella and Olive Oils-based Nutraceutical Formulation in Rats with Experimentally-Induced Alzheimer's Disease: A Mechanistic Insight. Journal of Chemical Neuroanatomy. 101878. PMID 33144183 DOI: 10.1016/j.jchemneu.2020.101878   
2020 Chen WT, Kuo YY, Lin GB, Lu CH, Hsu HP, Sun YK, Chao CY. Thermal cycling protects SH-SY5Y cells against hydrogen peroxide and β-amyloid-induced cell injury through stress response mechanisms involving Akt pathway. Plos One. 15: e0240022. PMID 33002038 DOI: 10.1371/journal.pone.0240022   
2020 Akter R, Chowdhury MAR, Habib Ur Rahman M. Antioxidant as Talented Drug Applicants for the Treatment of Alzheimer's Disease and their Molecular Mechanism Insights. Current Pharmaceutical Design. PMID 33138754 DOI: 10.2174/1381612826666201102102810   
2020 Tagai N, Tanaka A, Sato A, Uchiumi F, Tanuma SI. Low Levels of Brain-Derived Neurotrophic Factor Trigger Self-aggregated Amyloid β-Induced Neuronal Cell Death in an Alzheimer's Cell Model. Biological & Pharmaceutical Bulletin. 43: 1073-1080. PMID 32612070 DOI: 10.1248/bpb.b20-00082   
2020 Krishnan S, Shrestha Y, Jayatunga DPW, Rea S, Martins R, Bharadwaj P. Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32937909 DOI: 10.3390/ijms21186739   
2020 Qu X, Guan P, Han L, Wang Z, Huang X. Levistolide A Attenuates Alzheimer's Pathology Through Activation of the PPARγ Pathway. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33034847 DOI: 10.1007/s13311-020-00943-1   
2020 Du Y, Luo M, Du Y, Xu M, Yao Q, Wang K, He G. Liquiritigenin Decreases Aβ Levels and Ameliorates Cognitive Decline by Regulating Microglia M1/M2 Transformation in AD Mice. Neurotoxicity Research. PMID 32990912 DOI: 10.1007/s12640-020-00284-z   
2020 Perea JR, Bolós M, Avila J. Microglia in Alzheimer's Disease in the Context of Tau Pathology. Biomolecules. 10. PMID 33066368 DOI: 10.3390/biom10101439   
2020 Huang L, McClatchy DB, Maher P, Liang Z, Diedrich JK, Soriano-Castell D, Goldberg J, Shokhirev M, Yates JR, Schubert D, Currais A. Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death. Cell Death & Disease. 11: 828. PMID 33024077 DOI: 10.1038/s41419-020-03020-9   
2020 Ahmad R, Khan A, Lee HJ, Ur Rehman I, Khan I, Alam SI, Kim MO. Lupeol, a Plant-Derived Flavonoid, Protects Mice Brains against Aβ-Induced Oxidative Stress and Neurodegeneration. Biomedicines. 8. PMID 32993092 DOI: 10.3390/biomedicines8100380   
2020 Rajendran K, Chellappan DR, Sankaranarayanan S, Ramakrishnan V, Krishnan UM. Investigations on a polyherbal formulation for treatment of cognitive impairment in a cholinergic dysfunctional rodent model. Neurochemistry International. 141: 104890. PMID 33122033 DOI: 10.1016/j.neuint.2020.104890   
2020 Ma WH, Chen AF, Xie XY, Huang YS. Sigma ligands as potent inhibitors of Aβ and AβOs in neurons and promising therapeutic agents of Alzheimer's disease. Neuropharmacology. 108342. PMID 33045243 DOI: 10.1016/j.neuropharm.2020.108342   
2020 Poon CH, Wang Y, Fung ML, Zhang C, Lim LW. Rodent Models of Amyloid-Beta Feature of Alzheimer's Disease: Development and Potential Treatment Implications. Aging and Disease. 11: 1235-1259. PMID 33014535 DOI: 10.14336/AD.2019.1026   
2020 Ju Y, Chakravarty H, Tam KY. An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease. Acs Chemical Neuroscience. PMID 33001625 DOI: 10.1021/acschemneuro.0c00464   
2020 Yang H, Mu W, Wei D, Zhang Y, Duan Y, Gao JX, Gong XQ, Wang HJ, Wu XL, Tao H, Chang J. A Novel Targeted and High-Efficiency Nanosystem for Combinational Therapy for Alzheimer's Disease. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 7: 1902906. PMID 33042734 DOI: 10.1002/advs.201902906   
2020 Luo F, Sandhu AF, Rungratanawanich W, Williams GE, Akbar M, Zhou S, Song BJ, Wang X. Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases. International Journal of Molecular Sciences. 21. PMID 32998479 DOI: 10.3390/ijms21197174   
2020 Alam J. Vitamins: a nutritional intervention to modulate the Alzheimer's disease progression. Nutritional Neuroscience. 1-18. PMID 32998670 DOI: 10.1080/1028415X.2020.1826762   
2020 Osama A, Zhang J, Yao J, Yao X, Fang J. Nrf2: a dark horse in Alzheimer's disease treatment. Ageing Research Reviews. 101206. PMID 33144124 DOI: 10.1016/j.arr.2020.101206   
2020 Doustar J, Rentsendorj A, Torbati T, Regis GC, Fuchs DT, Sheyn J, Mirzaei N, Graham SL, Shah PK, Mastali M, Van Eyk JE, Black KL, Gupta VK, Mirzaei M, Koronyo Y, et al. Parallels between retinal and brain pathology and response to immunotherapy in old, late-stage Alzheimer's disease mouse models. Aging Cell. e13246. PMID 33090673 DOI: 10.1111/acel.13246   
2020 Garcia-Leon JA, Caceres-Palomo L, Sanchez-Mejias E, Mejias-Ortega M, Nuñez-Diaz C, Fernandez-Valenzuela JJ, Sanchez-Varo R, Davila JC, Vitorica J, Gutierrez A. Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32962164 DOI: 10.3390/ijms21186867   
2020 Hao F, Feng Y. Cannabidiol (CBD) enhanced the hippocampal immune response and autophagy of APP/PS1 Alzheimer's mice uncovered by RNA-seq. Life Sciences. 118624. PMID 33096116 DOI: 10.1016/j.lfs.2020.118624   
2020 Scholes HM, Cryar A, Kerr F, Sutherland D, Gethings LA, Vissers JPC, Lees JG, Orengo CA, Partridge L, Thalassinos K. Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila. Scientific Reports. 10: 18517. PMID 33116184 DOI: 10.1038/s41598-020-74748-9   
2020 Ma Y, McClatchy DB, Martínez-Bartolomé S, Bamberger C, Yates JR. Temporal Quantitative Profiling of Newly Synthesized Proteins during Aβ Accumulation. Journal of Proteome Research. PMID 33147027 DOI: 10.1021/acs.jproteome.0c00645   
2020 Edler MK, Munger EL, Meindl RS, Hopkins WD, Ely JJ, Erwin JM, Mufson EJ, Hof PR, Sherwood CC, Raghanti MA. Neuron loss associated with age but not Alzheimer's disease pathology in the chimpanzee brain. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 375: 20190619. PMID 32951541 DOI: 10.1098/rstb.2019.0619   
2020 Lewcock JW, Schlepckow K, Di Paolo G, Tahirovic S, Monroe KM, Haass C. Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease. Neuron. PMID 33096024 DOI: 10.1016/j.neuron.2020.09.029   
2020 Caldwell KA, Willicott CW, Caldwell GA. Modeling neurodegeneration in . Disease Models & Mechanisms. 13. PMID 33106318 DOI: 10.1242/dmm.046110   
2020 Dhanwani R, Pham J, Premlal ALR, Frazier A, Kumar A, Pero ME, Bartolini F, Dutra JR, Marder KS, Peters B, Sulzer D, Sette A, Lindestam Arlehamn CS. T Cell Responses to Neural Autoantigens Are Similar in Alzheimer's Disease Patients and Age-Matched Healthy Controls. Frontiers in Neuroscience. 14: 874. PMID 32982670 DOI: 10.3389/fnins.2020.00874   
2020 Lau SF, Cao H, Fu AKY, Ip NY. Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 32989152 DOI: 10.1073/pnas.2008762117   
2020 Han F, Bi J, Qiao L, Arancio O. Stem Cell Therapy for Alzheimer's Disease. Advances in Experimental Medicine and Biology. 1266: 39-55. PMID 33105494 DOI: 10.1007/978-981-15-4370-8_4   
2020 Silva A, Pereira M, Carrascal MA, Brites G, Neves B, Moreira P, Resende R, Silva MM, Santos AE, Pereira C, Cruz MT. Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer's Disease Cellular Models. International Journal of Molecular Sciences. 21. PMID 33096789 DOI: 10.3390/ijms21207791   
2020 Broderick TL, Rasool S, Li R, Zhang Y, Anderson M, Al-Nakkash L, Plochocki JH, Geetha T, Babu JR. Neuroprotective Effects of Chronic Resveratrol Treatment and Exercise Training in the 3xTg-AD Mouse Model of Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 33020412 DOI: 10.3390/ijms21197337   
2020 Ashok A, Singh N, Chaudhary S, Bellamkonda V, Kritikos AE, Wise AS, Rana N, McDonald D, Ayyagari R. Retinal Degeneration and Alzheimer's Disease: An Evolving Link. International Journal of Molecular Sciences. 21. PMID 33023198 DOI: 10.3390/ijms21197290   
2020 Ashok A, Singh N, Chaudhary S, Bellamkonda V, Kritikos AE, Wise AS, Rana N, McDonald D, Ayyagari R. Retinal Degeneration and Alzheimer's Disease: An Evolving Link. International Journal of Molecular Sciences. 21. PMID 33023198 DOI: 10.3390/ijms21197290   
2020 Al Mamun A, Rahman MM, Zaman S, Munira MS, Uddin MS, Rauf A, Banu N, Ashraf GM. Molecular Insight into the Crosstalk of UPS Components and Alzheimer's Disease. Current Protein & Peptide Science. PMID 32964822 DOI: 10.2174/1389203721666200923153406   
2020 Shen Y, Hua L, Yeh CK, Shen L, Ying M, Zhang Z, Liu G, Li S, Chen S, Chen X, Yang X. Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease. Theranostics. 10: 11794-11819. PMID 33052247 DOI: 10.7150/thno.44152   
2020 Peng SY, Wu X, Lu T, Cui G, Chen G. Research progress of hydrogen sulfide in Alzheimer's disease from laboratory to hospital: a narrative review. Medical Gas Research. 10: 125-129. PMID 33004710 DOI: 10.4103/2045-9912.296043   
2020 Peng SY, Wu X, Lu T, Cui G, Chen G. Research progress of hydrogen sulfide in Alzheimer's disease from laboratory to hospital: a narrative review. Medical Gas Research. 10: 125-129. PMID 33004710 DOI: 10.4103/2045-9912.296043   
2020 Tan X, Liang Z, Li Y, Zhi Y, Yi L, Bai S, Forest KH, Nichols RA, Dong Y, Li QX. Isoorientin, a GSK-3β inhibitor, rescues synaptic dysfunction, spatial memory deficits and attenuates pathological progression in APP/PS1 model mice. Behavioural Brain Research. 112968. PMID 33069740 DOI: 10.1016/j.bbr.2020.112968   
2020 Von Schulze AT, Deng F, Morris JK, Geiger PC. Heat therapy: possible benefits for cognitive function and the aging brain. Journal of Applied Physiology (Bethesda, Md. : 1985). PMID 32969779 DOI: 10.1152/japplphysiol.00168.2020   
2020 Postu PA, Gorgan DL, Cioanca O, Russ M, Mikkat S, Glocker MO, Hritcu L. Memory-Enhancing Effects of Essential Oil in an Alzheimer's Amyloid beta1-42 Rat Model: A Molecular and Behavioral Study. Antioxidants (Basel, Switzerland). 9. PMID 32993114 DOI: 10.3390/antiox9100919   
2020 Gu H, Territo PR, Persohn SA, Bedwell AA, Eldridge K, Speedy R, Chen Z, Zheng W, Du Y. Evaluation of chronic lead effects in the blood brain barrier system by DCE-CT. Journal of Trace Elements in Medicine and Biology : Organ of the Society For Minerals and Trace Elements (Gms). 62: 126648. PMID 32980769 DOI: 10.1016/j.jtemb.2020.126648   
2020 Duggan MR, Torkzaban B, Ahooyi TM, Khalili K. Potential Role for Herpesviruses in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 33074235 DOI: 10.3233/JAD-200814   
2020 Fan YG, Pang ZQ, Wu TY, Zhang YH, Xuan WQ, Wang Z, Yu X, Li YC, Guo C, Wang ZY. Vitamin D deficiency exacerbates Alzheimer-like pathologies by reducing antioxidant capacity. Free Radical Biology & Medicine. PMID 33068737 DOI: 10.1016/j.freeradbiomed.2020.10.007   
2020 Dare LR, Garcia A, Soares CB, Lopes L, Neves BS, Dias DV, Mello-Carpes PB. The Reversal of Memory Deficits in an Alzheimer's Disease Model Using Physical and Cognitive Exercise. Frontiers in Behavioral Neuroscience. 14: 152. PMID 32973471 DOI: 10.3389/fnbeh.2020.00152   
2020 Shinohara M, Kanekiyo T, Tachibana M, Kurti A, Shinohara M, Fu Y, Zhao J, Han X, Sullivan PM, Rebeck GW, Fryer JD, Heckman MG, Bu G. is associated with longevity independent of Alzheimer's disease. Elife. 9. PMID 33074098 DOI: 10.7554/eLife.62199   
2020 de Matos AM, Blázquez-Sánchez MT, Bento-Oliveira A, de Almeida R, Nunes RS, LOpes P, Machuqueiro M, Cristovão J, Gomes CM, Souza CS, El Idrissi IG, Colabufo NA, Diniz A, Marcelo F, Oliveira MC, et al. Glucosylpolyphenols as inhibitors of Aβ-induced Fyn kinase activation and Tau phosphorylation: synthesis, membrane permeability, and exploratory target assessment within the scope of type 2 diabetes and Alzheimer's disease. Journal of Medicinal Chemistry. PMID 32959649 DOI: 10.1021/acs.jmedchem.0c00841   
2020 Ding Y, Liu H, Cen M, Tao Y, Lai C, Tang Z. Rapamycin Ameliorates Cognitive Impairments and Alzheimer's Disease-Like Pathology with Restoring Mitochondrial Abnormality in the Hippocampus of Streptozotocin-Induced Diabetic Mice. Neurochemical Research. PMID 33140268 DOI: 10.1007/s11064-020-03160-6   
2020 Alcalà-Vida R, Awada A, Boutillier AL, Merienne K. Epigenetic mechanisms underlying enhancer modulation of neuronal identity, neuronal activity and neurodegeneration. Neurobiology of Disease. 147: 105155. PMID 33127472 DOI: 10.1016/j.nbd.2020.105155