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Zhihong Chen - Publications

Affiliations: 
Emory University, Atlanta, GA 
Area:
Neuroinflammation
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48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Chomyk A, Kucinski R, Kim J, Christie E, Cyncynatus K, Gossman Z, Chen Z, Richardson B, Cameron M, Turner T, Dutta R, Trapp B. Transcript Profiles of Microglia/Macrophage Cells at the Borders of Chronic Active and Subpial Gray Matter Lesions in Multiple Sclerosis. Annals of Neurology. PMID 38345145 DOI: 10.1002/ana.26877  0.47
2023 Chen Z, Giotti B, Kaluzova M, Puigdelloses Vallcorba M, Rawat K, Price G, Herting CJ, Piñero G, Cristea S, Ross JL, Ackley J, Maximov V, Szulzewsky F, Thomason W, Marquez-Ropero M, et al. A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression. The Journal of Clinical Investigation. PMID 37733448 DOI: 10.1172/JCI163802  0.597
2023 Sattiraju A, Kang S, Giotti B, Chen Z, Marallano VJ, Brusco C, Ramakrishnan A, Shen L, Tsankov AM, Hambardzumyan D, Friedel RH, Zou H. Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression. Immunity. PMID 37451265 DOI: 10.1016/j.immuni.2023.06.017  0.639
2023 Chen Z, Soni N, Pinero G, Giotti B, Eddins DJ, Lindblad KE, Ross JL, Puigdelloses Vallcorba M, Joshi T, Angione A, Thomason W, Keane A, Tsankova NM, Gutmann DH, Lira SA, et al. Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma. Nature Communications. 14: 1839. PMID 37012245 DOI: 10.1038/s41467-023-37361-8  0.657
2023 Wang Y, Chu Y, Cao F, Chen Z, Xu H, Wang S, Ma J. The emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumor. Central-European Journal of Immunology. 47: 373-381. PMID 36817396 DOI: 10.5114/ceji.2022.124387  0.371
2023 Chen Z, Hu W, Mendez MJ, Gossman ZC, Chomyk A, Boylan BT, Kidd GJ, Phares TW, Bergmann CC, Trapp BD. Neuroprotection by Preconditioning in Mice is Dependent on MyD88-Mediated CXCL10 Expression in Endothelial Cells. Asn Neuro. 15: 17590914221146365. PMID 36591943 DOI: 10.1177/17590914221146365  0.696
2021 Puigdelloses M, Garcia-Moure M, Labiano S, Laspidea V, Gonzalez-Huarriz M, Zalacain M, Marrodan L, Martinez-Velez N, De la Nava D, Ausejo I, Hervás-Stubbs S, Herrador G, Chen Z, Hambardzumyan D, Patino Garcia A, et al. CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models. Journal For Immunotherapy of Cancer. 9. PMID 34281988 DOI: 10.1136/jitc-2021-002644  0.622
2021 Chen Z, Hambardzumyan D. Macrophage-tumor cell intertwine drives the transition into a mesenchymal-like cellular state of glioblastoma. Cancer Cell. PMID 34087163 DOI: 10.1016/j.ccell.2021.05.003  0.617
2021 Zhang S, Jiang VC, Han G, Hao D, Lian J, Liu Y, Zhang R, McIntosh J, Wang R, Dang M, Dai E, Wang Y, Santos D, Badillo M, Leeming A, ... Chen Z, et al. Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma. Nature Communications. 12: 2877. PMID 34001881 DOI: 10.1038/s41467-021-22872-z  0.352
2020 Ross JL, Chen Z, Herting CJ, Grabovska Y, Szulzewsky F, Puigdelloses M, Monterroza L, Switchenko J, Wadhwani NR, Cimino PJ, Mackay A, Jones C, Read RD, MacDonald TJ, Schniederjan M, et al. Platelet-derived growth factor beta is a potent inflammatory driver in paediatric high-grade glioma. Brain : a Journal of Neurology. PMID 33300045 DOI: 10.1093/brain/awaa382  0.62
2020 Chen Z, Herting CJ, Ross JL, Gabanic B, Puigdelloses Vallcorba M, Szulzewsky F, Wojciechowicz ML, Cimino PJ, Ezhilarasan R, Sulman EP, Ying M, Ma'ayan A, Read RD, Hambardzumyan D. Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade. Glia. PMID 32639068 DOI: 10.1002/Glia.23883  0.661
2020 Alexander J, LaPlant QC, Pattwell SS, Szulzewsky F, Cimino PJ, Caruso FP, Pugliese P, Chen Z, Chardon F, Hill AJ, Spurrell C, Ahrendsen D, Pietras A, Starita LM, Hambardzumyan D, et al. Multimodal single-cell analysis reveals distinct radioresistant stem-like and progenitor cell populations in murine glioma. Glia. PMID 32621641 DOI: 10.1002/Glia.23866  0.621
2020 Haage V, Semtner M, Vidal RO, Hernandez DP, Pong WW, Chen Z, Hambardzumyan D, Magrini V, Ly A, Walker J, Mardis E, Mertins P, Sauer S, Kettenmann H, Gutmann DH. Correction to: Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma. Acta Neuropathologica Communications. 8: 1. PMID 31915069 DOI: 10.1186/S40478-019-0875-3  0.569
2019 Herting CJ, Chen Z, Maximov V, Duffy A, Szulzewsky F, Shayakhmetov DM, Hambardzumyan D. Tumour-associated macrophage-derived interleukin-1 mediates glioblastoma-associated cerebral oedema. Brain : a Journal of Neurology. PMID 31665239 DOI: 10.1093/Brain/Awz331  0.655
2019 Kaffes I, Szulzewsky F, Chen Z, Herting CJ, Gabanic B, Velázquez Vega JE, Shelton J, Switchenko JM, Ross JL, McSwain LF, Huse JT, Westermark B, Nelander S, Forsberg-Nilsson K, Uhrbom L, et al. Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors. Oncoimmunology. 8: e1655360. PMID 31646100 DOI: 10.1080/2162402X.2019.1655360  0.704
2019 Chen Z, Ross JL, Hambardzumyan D. Intravital 2-photon imaging reveals distinct morphology and infiltrative properties of glioblastoma-associated macrophages. Proceedings of the National Academy of Sciences of the United States of America. PMID 31235603 DOI: 10.1073/Pnas.1902366116  0.682
2019 Maximov V, Chen Z, Wei Y, Robinson MH, Herting CJ, Shanmugam NS, Rudneva VA, Goldsmith KC, MacDonald TJ, Northcott PA, Hambardzumyan D, Kenney AM. Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma. Nature Communications. 10: 2410. PMID 31160587 DOI: 10.1038/S41467-019-10458-9  0.624
2019 Haage V, Semtner M, Vidal RO, Hernandez DP, Pong WW, Chen Z, Hambardzumyan D, Magrini V, Ly A, Walker J, Mardis E, Mertins P, Sauer S, Kettenmann H, Gutmann DH. Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma. Acta Neuropathologica Communications. 7: 20. PMID 30764877 DOI: 10.1186/S40478-019-0665-Y  0.65
2019 Chen Z, Hurting CJ, Gabanic B, Murukuti J, Hambardzumyan D. Abstract 1100: Genetic driver-mutations define composition and properties of tumor-associated myeloid cells in glioblastoma Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-1100  0.637
2019 Ross J, Chen Z, Herting C, Szulzewsky F, Becher O, MacDonald T, Schniederjan M, Hambardzumyan D. PDTM-11. GAINING INSIGHTS INTO THE INFLAMMATORY MICROENVIRONMENT OF PEDIATRIC HIGH-GRADE GLIOMAS USING GEMMs AND PATIENT SAMPLES Neuro-Oncology. 21: vi189-vi189. DOI: 10.1093/Neuonc/Noz175.787  0.696
2019 Ross J, Chen Z, Szulzewsky F, Monterroza L, Schniederjan M, Becher O, Hambardzumyan D. TMOD-09. TUMOR ASSOCIATED MACROPHAGE DYNAMICS IN PEDIATRIC HIGH-GRADE GLIOMAS Neuro-Oncology. 21: ii123-ii123. DOI: 10.1093/Neuonc/Noz036.247  0.654
2018 Chen Z, Hambardzumyan D. Immune Microenvironment in Glioblastoma Subtypes. Frontiers in Immunology. 9: 1004. PMID 29867979 DOI: 10.3389/Fimmu.2018.01004  0.695
2018 Sadahiro H, Kang KD, Gibson JT, Minata M, Yu H, Shi J, Chhipa RR, Chen Z, Lu S, Simoni Y, Furuta T, Sabit H, Zhang S, Bastola S, Yamaguchi S, et al. Activation of the receptor tyrosine kinase AXL regulates the immune microenvironment in glioblastoma. Cancer Research. PMID 29531161 DOI: 10.1158/0008-5472.Can-17-2433  0.672
2018 Ross J, Chen Z, Szulzewsky F, Schniederjan M, Becher O, Hambardzumyan D. PDTM-43. THE ROLE OF TUMOR ASSOCIATED MACROPHAGES IN PEDIATRIC HIGH-GRADE GLIOMA Neuro-Oncology. 20: vi213-vi213. DOI: 10.1093/Neuonc/Noy148.882  0.668
2018 Chen Z, Murukuti J, Hambardzumyan D. TMIC-31. GENETIC DRIVER-MUTATIONS DEFINE COMPOSITION AND PROPERTIES OF TUMOR-ASSOCIATED MYELOID CELLS IN GLIOBLASTOMA Neuro-Oncology. 20: vi262-vi263. DOI: 10.1093/Neuonc/Noy148.1090  0.639
2018 Ghosh S, Sadahiro H, Kang K, Gibson JT, Minata M, Yu H, Shi J, Chhipa R, Chen Z, Lu S, Simoni Y, Furuta T, Sabit H, Zhang S, Bastola S, et al. ACTR-20. A SMALL MOLECULE AXL INHIBITOR, BGB324 – FIRST-IN-HUMAN GBM SURGICAL PK TRIAL FOR RECURRENT TUMORS Neuro-Oncology. 20: vi15-vi15. DOI: 10.1093/Neuonc/Noy148.054  0.597
2017 Herting CJ, Chen Z, Pitter KL, Szulzewsky F, Kaffes I, Kaluzova M, Park JC, Cimino PJ, Brennan C, Wang B, Hambardzumyan D. Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas. Glia. PMID 28836293 DOI: 10.1002/Glia.23203  0.683
2017 Meller J, Chen Z, Dudiki T, Cull RM, Murtazina R, Bal SK, Pluskota E, Stefl S, Plow EF, Trapp BD, Byzova TV. Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages. Jci Insight. 2. PMID 28570266 DOI: 10.1172/Jci.Insight.93002  0.573
2017 Chen Z, Feng X, Herting CJ, Alvarez Garcia V, Nie K, Pong WW, Rasmussen R, Dwivedi B, Seby S, Wolf SA, Gutmann DH, Hambardzumyan D. Cellular and molecular identity of tumor-associated macrophages in glioblastoma. Cancer Research. PMID 28235764 DOI: 10.1158/0008-5472.Can-16-2310  0.703
2017 Chen Z, Hambardzumyan D. TMIC-02. GENETIC DRIVER-MUTATIONS DEFINE THE TUMORS ASSOCIATED MACROPHAGE COMPOSITION AND FUNCTION IN GLIOBLASTOMA Neuro-Oncology. 19: vi243-vi243. DOI: 10.1093/Neuonc/Nox168.992  0.644
2017 Maximov V, Chen Z, Wei Y, Robinson MH, Hambardzumyan D, Kenney A. TMIC-17. THE ROLE OF TUMOR-ASSOCIATED MACROPHAGES IN A MURINE SONIC HEDGEHOG MEDULLOBLASTOMA MODEL Neuro-Oncology. 19: vi246-vi247. DOI: 10.1093/Neuonc/Nox168.1007  0.665
2016 Chen Z, Feng X, Nie K, Pong WW, Rasmussen R, Gutmann D, Hambardzumyan D. TMIC-06. IDENTITY AND GENE PROFILE OF TUMOR-ASSOCIATED MACROPHAGES IN GLIOBLASTOMA Neuro-Oncology. 18: vi200-vi201. DOI: 10.1093/Neuonc/Now212.846  0.648
2015 Feng X, Szulzewsky F, Yerevanian A, Chen Z, Heinzmann D, Rasmussen RD, Alvarez-Garcia V, Kim Y, Wang B, Tamagno I, Zhou H, Li X, Kettenmann H, Ransohoff RM, Hambardzumyan D. Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis. Oncotarget. 6: 15077-94. PMID 25987130 DOI: 10.18632/Oncotarget.3730  0.693
2015 Savarin C, Hinton DR, Valentin-Torres A, Chen Z, Trapp BD, Bergmann CC, Stohlman SA. Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis. Journal of Neuroinflammation. 12: 79. PMID 25896970 DOI: 10.1186/S12974-015-0293-9  0.507
2015 Chen Z, Chen JT, Johnson M, Gossman ZC, Hendrickson M, Sakaie K, Martinez-Rubio C, Gale JT, Trapp BD. Cuprizone does not induce CNS demyelination in nonhuman primates. Annals of Clinical and Translational Neurology. 2: 208-13. PMID 25750925 DOI: 10.1002/Acn3.159  0.497
2015 Chen Z, Trapp BD. Microglia and neuroprotection. Journal of Neurochemistry. PMID 25693054 DOI: 10.1111/Jnc.13062  0.575
2014 Chen Z, Jalabi W, Hu W, Park HJ, Gale JT, Kidd GJ, Bernatowicz R, Gossman ZC, Chen JT, Dutta R, Trapp BD. Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain. Nature Communications. 5: 4486. PMID 25047355 DOI: 10.1038/Ncomms5486  0.676
2014 Liu C, Ma Z, Xu S, Hou J, Hu Y, Yu Y, Liu R, Chen Z, Lu Y. Activation of the germ-cell potential of human bone marrow-derived cells by a chemical carcinogen. Scientific Reports. 4: 5564. PMID 24998261 DOI: 10.1038/srep05564  0.308
2014 Cooperrider J, Furmaga H, Plow E, Park HJ, Chen Z, Kidd G, Baker KB, Gale JT, Machado AG. Chronic deep cerebellar stimulation promotes long-term potentiation, microstructural plasticity, and reorganization of perilesional cortical representation in a rodent model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 9040-50. PMID 24990924 DOI: 10.1523/Jneurosci.0953-14.2014  0.597
2014 Chen Z, Forman LW, Williams RM, Faller DV. Protein kinase C-δ inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo. Bmc Cancer. 14: 90. PMID 24528676 DOI: 10.1186/1471-2407-14-90  0.3
2013 Nikolakopoulou AM, Dutta R, Chen Z, Miller RH, Trapp BD. Activated microglia enhance neurogenesis via trypsinogen secretion. Proceedings of the National Academy of Sciences of the United States of America. 110: 8714-9. PMID 23650361 DOI: 10.1073/Pnas.1218856110  0.557
2012 Chen Z, Jalabi W, Shpargel KB, Farabaugh KT, Dutta R, Yin X, Kidd GJ, Bergmann CC, Stohlman SA, Trapp BD. Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11706-15. PMID 22915113 DOI: 10.1523/Jneurosci.0730-12.2012  0.7
2011 Chen Z, Freedman MS. γδ T cells and multiple sclerosis: Friends, foes, or both? Autoimmunity Reviews. 10: 364-7. PMID 21195807 DOI: 10.1016/J.Autrev.2010.12.005  0.52
2008 Darlington PJ, Podjaski C, Horn KE, Costantino S, Blain M, Saikali P, Chen Z, Baker KA, Newcombe J, Freedman M, Wiseman PW, Bar-Or A, Kennedy TE, Antel JP. Innate immune-mediated neuronal injury consequent to loss of astrocytes. Journal of Neuropathology and Experimental Neurology. 67: 590-9. PMID 18520777 DOI: 10.1097/Nen.0B013E3181772Cf6  0.529
2008 Chen Z, Freedman MS. CD16+ gammadelta T cells mediate antibody dependent cellular cytotoxicity: potential mechanism in the pathogenesis of multiple sclerosis. Clinical Immunology (Orlando, Fla.). 128: 219-27. PMID 18501678 DOI: 10.1016/J.Clim.2008.03.513  0.534
2008 Chen Z, Freedman MS. Correlation of specialized CD16(+) gammadelta T cells with disease course and severity in multiple sclerosis. Journal of Neuroimmunology. 194: 147-52. PMID 18155780 DOI: 10.1016/J.Jneuroim.2007.11.010  0.528
2007 Saikali P, Antel JP, Newcombe J, Chen Z, Freedman M, Blain M, Cayrol R, Prat A, Hall JA, Arbour N. NKG2D-mediated cytotoxicity toward oligodendrocytes suggests a mechanism for tissue injury in multiple sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1220-8. PMID 17267578 DOI: 10.1523/Jneurosci.4402-06.2007  0.57
2006 Liu C, Chen Z, Chen Z, Zhang T, Lu Y. Multiple tumor types may originate from bone marrow-derived cells. Neoplasia (New York, N.Y.). 8: 716-24. PMID 16984729 DOI: 10.1593/neo.06253  0.318
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