| Year |
Citation |
Score |
| 2023 |
Hasan M, Panda D, Mann G, Brik A. De novo Semi-synthetic Platform for Monitoring Protein degradation in Live Cells. Chembiochem : a European Journal of Chemical Biology. e202300731. PMID 38031893 DOI: 10.1002/cbic.202300731 |
0.311 |
|
| 2023 |
Lemma B, Zhang D, Vamisetti GB, Wentz BG, Suga H, Brik A, Lubkowski J, Fushman D. Mechanism of selective recognition of Lys48-linked polyubiquitin by macrocyclic peptide inhibitors of proteasomal degradation. Nature Communications. 14: 7212. PMID 37938554 DOI: 10.1038/s41467-023-43025-4 |
0.316 |
|
| 2023 |
Kriegesmann J, Brik A. Synthesis of ubiquitinated proteins for biochemical and functional analysis. Chemical Science. 14: 10025-10040. PMID 37772107 DOI: 10.1039/d3sc03664b |
0.381 |
|
| 2023 |
Parisis N, Dans PD, Jbara M, Singh B, Schausi-Tiffoche D, Molina-Serrano D, Brun-Heath I, Hendrychová D, Maity SK, Buitrago D, Lema R, Nait Achour T, Giunta S, Girardot M, Talarek N, ... ... Brik A, et al. Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair. Nature Communications. 14: 5104. PMID 37607906 DOI: 10.1038/s41467-023-40843-4 |
0.693 |
|
| 2023 |
Saha A, Suga H, Brik A. Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes. Accounts of Chemical Research. PMID 37312234 DOI: 10.1021/acs.accounts.3c00178 |
0.432 |
|
| 2022 |
Vamisetti GB, Saha A, Huang YJ, Vanjari R, Mann G, Gutbrod J, Ayoub N, Suga H, Brik A. Selective macrocyclic peptide modulators of Lys63-linked ubiquitin chains disrupt DNA damage repair. Nature Communications. 13: 6174. PMID 36257952 DOI: 10.1038/s41467-022-33808-6 |
0.355 |
|
| 2022 |
Mann G, Sulkshane P, Sadhu P, Ziv T, Glickman MH, Brik A. Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1. Molecules (Basel, Switzerland). 27. PMID 35956818 DOI: 10.3390/molecules27154867 |
0.302 |
|
| 2022 |
Mann G, Sadhu P, Brik A. Synthetic Proteins behind the Plasma Barrier: Molecular Spies. Accounts of Chemical Research. 55: 2055-2067. PMID 35833291 DOI: 10.1021/acs.accounts.2c00236 |
0.414 |
|
| 2022 |
Vanjari R, Panda D, Mandal S, Vamisetti GB, Brik A. Gold(I)-Mediated Rapid Cyclization of Propargylated Peptides via Imine Formation. Journal of the American Chemical Society. 144: 4966-4976. PMID 35258952 DOI: 10.1021/jacs.1c12906 |
0.32 |
|
| 2022 |
Mann G, Sadhu P, Brik A. Multiplexed Delivery of Synthetic (Un)Conjugatable Ubiquitin and SUMO2 Enables Simultaneous Monitoring of Their Localization and Function in Live Cells. Chembiochem : a European Journal of Chemical Biology. e202200122. PMID 35235714 DOI: 10.1002/cbic.202200122 |
0.334 |
|
| 2021 |
Sahu I, Mali SM, Sulkshane P, Xu C, Rozenberg A, Morag R, Sahoo MP, Singh SK, Ding Z, Wang Y, Day S, Cong Y, Kleifeld O, Brik A, Glickman MH. The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag. Nature Communications. 12: 6173. PMID 34702852 DOI: 10.1038/s41467-021-26427-0 |
0.306 |
|
| 2021 |
Mann G, Satish G, Sulkshane P, Mandal S, Glickman MH, Brik A. Synthesis and delivery of a stable phosphorylated ubiquitin probe to study ubiquitin conjugation in mitophagy. Chemical Communications (Cambridge, England). 57: 9438-9441. PMID 34528945 DOI: 10.1039/d1cc04045f |
0.312 |
|
| 2021 |
Mandal S, Mann G, Satish G, Brik A. Enhanced Live-Cell Delivery of Synthetic Proteins Assisted by Cell-Penetrating Peptides Fused to DABCYL. Angewandte Chemie (International Ed. in English). PMID 33615660 DOI: 10.1002/anie.202016208 |
0.336 |
|
| 2021 |
Laps S, Atamleh F, Kamnesky G, Sun H, Brik A. General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins. Nature Communications. 12: 870. PMID 33558523 DOI: 10.1038/s41467-021-21209-0 |
0.356 |
|
| 2021 |
Laps S, Satish G, Brik A. Harnessing the power of transition metals in solid-phase peptide synthesis and key steps in the (semi)synthesis of proteins. Chemical Society Reviews. PMID 33432943 DOI: 10.1039/d0cs01156h |
0.344 |
|
| 2020 |
Brik A, Vamisetti GB, Meledin R, Nawatha M, Suga H. Development of fluorescence-based competitive assay enabled the discovery of dimeric cyclicpeptide modulators of ubiquitin chains. Angewandte Chemie (International Ed. in English). PMID 33326152 DOI: 10.1002/anie.202013392 |
0.314 |
|
| 2020 |
Vamisetti GB, Satish G, Sulkshane P, Mann G, Glickman MH, Brik A. On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins. Journal of the American Chemical Society. PMID 33136379 DOI: 10.1021/jacs.0c07663 |
0.441 |
|
| 2020 |
Msallam M, Sun H, Meledin R, Franz P, Brik A. Examining the role of phosphorylation of p19 in its stability and ubiquitination using chemical protein synthesis. Chemical Science. 11: 5526-5531. PMID 32874495 DOI: 10.1039/C9Sc06300E |
0.382 |
|
| 2020 |
Jbara M, Eid E, Brik A. Gold(I)-Mediated Decaging or Cleavage of Propargylated Peptide Bond in Aqueous Conditions for Protein Synthesis and Manipulation. Journal of the American Chemical Society. PMID 32290655 DOI: 10.1021/Jacs.9B13216 |
0.807 |
|
| 2020 |
Suga H, Brik A, Huang Y, Nawatha M. Affinity Maturation of Macrocyclic Peptide Modulators of Lys48-linked Diubiquitin by a Twofold Strategy. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32105365 DOI: 10.1002/Chem.202000273 |
0.373 |
|
| 2020 |
Eid E, Boross GN, Sun H, Msallam M, Singh SK, Brik A. Total Chemical Synthesis of ISGylated-Ubiquitin Hybrid Chain Assisted by Acetamidomethyl Derivatives with Dual Functions. Bioconjugate Chemistry. PMID 32069038 DOI: 10.1021/Acs.Bioconjchem.0C00026 |
0.431 |
|
| 2019 |
Sun H, Brik A. The Journey for the Total Chemical Synthesis of a 53 kDa Protein. Accounts of Chemical Research. PMID 31536331 DOI: 10.1021/Acs.Accounts.9B00372 |
0.564 |
|
| 2019 |
Mann G, Satish G, Meledin R, Vamisetti GB, Brik A. Palladium-Mediated Cleavage of Proteins with Thiazolidine-Modified Backbone in Live Cells. Angewandte Chemie (International Ed. in English). 58: 13540-13549. PMID 31402546 DOI: 10.1002/Anie.201906545 |
0.491 |
|
| 2019 |
Nawatha M, Rogers JM, Bonn SM, Livneh I, Lemma B, Mali SM, Vamisetti GB, Sun H, Bercovich B, Huang Y, Ciechanover A, Fushman D, Suga H, Brik A. De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains. Nature Chemistry. PMID 31182821 DOI: 10.1038/S41557-019-0278-X |
0.442 |
|
| 2019 |
Meledin R, Brik A. Mirroring Life's Building Blocks. Cell Chemical Biology. 26: 616-619. PMID 31100259 DOI: 10.1016/J.Chembiol.2019.04.013 |
0.358 |
|
| 2019 |
Sun H, Mali SM, Singh SK, Meledin R, Brik A, Kwon YT, Kravtsova-Ivantsiv Y, Bercovich B, Ciechanover A. Diverse fate of ubiquitin chain moieties: The proximal is degraded with the target, and the distal protects the proximal from removal and recycles. Proceedings of the National Academy of Sciences of the United States of America. PMID 30867293 DOI: 10.1073/Pnas.1822148116 |
0.362 |
|
| 2019 |
Morgan M, Jbara M, Brik A, Wolberger C. Semisynthesis of ubiquitinated histone H2B with a native or nonhydrolyzable linkage. Methods in Enzymology. 618: 1-27. PMID 30850047 DOI: 10.1016/Bs.Mie.2019.01.003 |
0.814 |
|
| 2019 |
Brik A, Laps S, Sun H, Kamnesky G. Palladium Mediated Direct Disulfide Bond Formation in Proteins Containing S-Acetamidomethyl-Cysteine under Aqueous Conditions. Angewandte Chemie (International Ed. in English). PMID 30828918 DOI: 10.1002/Anie.201900988 |
0.444 |
|
| 2019 |
Nune M, Morgan MT, Connell Z, McCullough L, Jbara M, Sun H, Brik A, Formosa T, Wolberger C. FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics. Elife. 8. PMID 30681413 DOI: 10.7554/Elife.40988 |
0.779 |
|
| 2019 |
Vamisetti GB, Meledin R, Gopinath P, Brik A. Halogen Substituents in the Isoquinoline Scaffold Switches the Selectivity of Inhibition between USP2 and USP7. Chembiochem : a European Journal of Chemical Biology. 20: 282-286. PMID 30474907 DOI: 10.1002/Cbic.201800612 |
0.323 |
|
| 2019 |
Jbara M, Maity SK, Brik A. Examining Several Strategies for the Chemical Synthesis of Phosphorylated Histone H3 Reveals the Effectiveness of the Convergent Approach European Journal of Organic Chemistry. 2020: 3128-3132. DOI: 10.1002/Ejoc.201900257 |
0.748 |
|
| 2018 |
Jbara M, Laps S, Morgan M, Kamnesky G, Mann G, Wolberger C, Brik A. Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins. Nature Communications. 9: 3154. PMID 30089783 DOI: 10.1038/S41467-018-05628-0 |
0.839 |
|
| 2018 |
Jbara M, Eid E, Brik A. Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites. Organic & Biomolecular Chemistry. PMID 29766191 DOI: 10.1039/C8Ob00890F |
0.784 |
|
| 2018 |
Sun H, Meledin R, Mali SM, Brik A. Total chemical synthesis of ester-linked ubiquitinated proteins unravels their behavior with deubiquitinases. Chemical Science. 9: 1661-1665. PMID 29675213 DOI: 10.1039/C7Sc04518B |
0.49 |
|
| 2018 |
Brik A, Meledin R, Mali S, Kleifeld O. Activity-Based Probes Developed by Applying Sequential Dehydroalanine Strategy on Expressed Proteins Reveal a Potential α-globin Modulating Deubiquitinase. Angewandte Chemie (International Ed. in English). PMID 29527788 DOI: 10.1002/Anie.201800032 |
0.349 |
|
| 2018 |
Jbara M, Sun H, Kamnesky G, Brik A. Chemical chromatin ubiquitylation. Current Opinion in Chemical Biology. 45: 18-26. PMID 29459258 DOI: 10.1016/J.Cbpa.2018.02.001 |
0.819 |
|
| 2018 |
Nune M, Morgan MT, Connell Z, McCullough L, Jbara M, Sun H, Brik A, Formosa T, Wolberger C. Author response: FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics Elife. DOI: 10.7554/Elife.40988.022 |
0.67 |
|
| 2017 |
Maity SK, Jbara M, Mann G, Kamnesky G, Brik A. Total chemical synthesis of histones and their analogs, assisted by native chemical ligation and palladium complexes. Nature Protocols. 12: 2293-2322. PMID 28981125 DOI: 10.1038/Nprot.2017.049 |
0.825 |
|
| 2017 |
Bondalapati S, Eid E, Mali SM, Wolberger C, Brik A. Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags. Chemical Science. 8: 4027-4034. PMID 28580118 DOI: 10.1039/C7Sc00488E |
0.455 |
|
| 2017 |
Jbara M, Guttmann-Raviv N, Maity SK, Ayoub N, Brik A. Total chemical synthesis of methylated analogues of histone 3 revealed KDM4D as a potential regulator of H3K79me3. Bioorganic & Medicinal Chemistry. PMID 28434780 DOI: 10.1016/J.Bmc.2017.04.015 |
0.793 |
|
| 2017 |
Brik A, Maity SK, Jbara M. Palladium in Chemical Protein Synthesis and Modifications. Angewandte Chemie (International Ed. in English). PMID 28383786 DOI: 10.1002/Anie.201702370 |
0.822 |
|
| 2017 |
Mali SM, Singh SK, Eid E, Brik A. Ubiquitin Signalling: Chemistry Comes to Rescue. Journal of the American Chemical Society. PMID 28328208 DOI: 10.1021/Jacs.7B00089 |
0.444 |
|
| 2017 |
Jbara M, Maity SK, Brik A. Palladium in der chemischen Synthese und Modifizierung von Proteinen Angewandte Chemie. 129: 10780-10792. DOI: 10.1002/Ange.201702370 |
0.78 |
|
| 2016 |
Singh SK, Sahu I, Mali SM, Hemantha HP, Kleifeld O, Glickman MH, Brik A. Synthetic Uncleavable Ubiquitinated Proteins Dissect Proteasome Deubiquitination and Degradation, and Highlight Distinctive Fate of Tetraubiquitin. Journal of the American Chemical Society. 138: 16004-16015. PMID 27960333 DOI: 10.1021/Jacs.6B09611 |
0.387 |
|
| 2016 |
Jbara M, Laps S, Maity SK, Brik A. Palladium-Assisted Cleavage of Peptides and Proteins Containing a Backbone with Thiazolidine Linkage. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27550063 DOI: 10.1002/Chem.201603676 |
0.815 |
|
| 2016 |
Maity SK, Mann G, Jbara M, Laps S, Kamnesky G, Brik A. Palladium-Assisted Removal of a Solubilizing Tag from a Cys Side Chain To Facilitate Peptide and Protein Synthesis. Organic Letters. PMID 27268382 DOI: 10.1021/Acs.Orglett.6B01442 |
0.828 |
|
| 2016 |
Meledin R, Mali SM, Singh SK, Brik A. Protein ubiquitination via dehydroalanine: development and insights into the diastereoselective 1,4-addition step. Organic & Biomolecular Chemistry. PMID 27143624 DOI: 10.1039/C6Ob00882H |
0.526 |
|
| 2016 |
Maity SK, Jbara M, Laps S, Brik A. Efficient Palladium-Assisted One-Pot Deprotection of (Acetamidomethyl)Cysteine Following Native Chemical Ligation and/or Desulfurization To Expedite Chemical Protein Synthesis. Angewandte Chemie (International Ed. in English). PMID 27126503 DOI: 10.1002/Anie.201603169 |
0.833 |
|
| 2016 |
Bondalapati S, Jbara M, Brik A. Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins. Nature Chemistry. 8: 407-18. PMID 27102674 DOI: 10.1038/Nchem.2476 |
0.83 |
|
| 2016 |
Gopinath P, Ohayon S, Nawatha M, Brik A. Chemical and semisynthetic approaches to study and target deubiquitinases. Chemical Society Reviews. PMID 27049734 DOI: 10.1039/C6Cs00083E |
0.454 |
|
| 2016 |
Jbara M, Maity SK, Seenaiah M, Brik A. Palladium Mediated Rapid Deprotection of N-Terminal Cysteine under Native Chemical Ligation Conditions for the Efficient Preparation of Synthetically Challenging Proteins. Journal of the American Chemical Society. 138: 5069-75. PMID 27023072 DOI: 10.1021/Jacs.5B13580 |
0.827 |
|
| 2016 |
Jbara M, Maity SK, Morgan M, Wolberger C, Brik A. Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module. Angewandte Chemie (International Ed. in English). PMID 26960207 DOI: 10.1002/Anie.201600638 |
0.806 |
|
| 2016 |
Morgan MT, Haj-Yahya M, Ringel AE, Bandi P, Brik A, Wolberger C. Structural basis for histone H2B deubiquitination by the SAGA DUB module. Science (New York, N.Y.). 351: 725-8. PMID 26912860 DOI: 10.1126/Science.Aac5681 |
0.401 |
|
| 2016 |
Maity SK, Jbara M, Brik A. Chemical and semisynthesis of modified histones. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 26778211 DOI: 10.1002/Psc.2848 |
0.82 |
|
| 2016 |
Meledin R, Mali SM, Brik A. Pushing the Boundaries of Chemical Protein Synthesis: The Case of Ubiquitin Chains and Polyubiquitinated Peptides and Proteins. Chemical Record (New York, N.Y.). 16: 509-19. PMID 26477936 DOI: 10.1002/Tcr.201500209 |
0.51 |
|
| 2016 |
Meledin R, Mali SM, Brik A. Pushing the Boundaries of Chemical Protein Synthesis: The Case of Ubiquitin Chains and Polyubiquitinated Peptides and Proteins Chemical Record. 16: 509-519. DOI: 10.1002/tcr.201500209 |
0.419 |
|
| 2015 |
Hemantha HP, Bondalapati S, Singh SK, Brik A. Chemical Synthesis of Ubiquitin Chains. Current Protocols in Chemical Biology. 7: 229-48. PMID 26629614 DOI: 10.1002/9780470559277.Ch150099 |
0.532 |
|
| 2015 |
Ohayon S, Refua M, Brik A. Rapid optimization of labeled ubiquitinated peptides for monitoring deubiquitinases activities. Organic & Biomolecular Chemistry. 13: 8182-6. PMID 26160015 DOI: 10.1039/C5Ob01142F |
0.494 |
|
| 2015 |
Maity SK, Ohayon S, Brik A. Synthesis of N-Hydroxy Isopeptide Containing Proteins. Organic Letters. 17: 3438-41. PMID 26111051 DOI: 10.1021/Acs.Orglett.5B01443 |
0.369 |
|
| 2015 |
Seenaiah M, Jbara M, Mali SM, Brik A. Convergent versus sequential protein synthesis: the case of ubiquitinated and glycosylated H2B. Angewandte Chemie (International Ed. in English). 54: 12374-8. PMID 26079184 DOI: 10.1002/Anie.201503309 |
0.831 |
|
| 2015 |
Kravtsova-Ivantsiv Y, Shomer I, Cohen-Kaplan V, Snijder B, Superti-Furga G, Gonen H, Sommer T, Ziv T, Admon A, Naroditsky I, Jbara M, Brik A, Pikarsky E, Kwon YT, Doweck I, et al. KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth. Cell. 161: 333-47. PMID 25860612 DOI: 10.1016/J.Cell.2015.03.001 |
0.748 |
|
| 2015 |
Bondalapati S, Mansour W, Nakasone MA, Maity SK, Glickman MH, Brik A. Chemical synthesis of phosphorylated ubiquitin and diubiquitin exposes positional sensitivities of e1-e2 enzymes and deubiquitinases. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 7360-4. PMID 25829361 DOI: 10.1002/Chem.201500540 |
0.339 |
|
| 2015 |
Ohayon S, Refua M, Hendler A, Aharoni A, Brik A. Harnessing the oxidation susceptibility of deubiquitinases for inhibition with small molecules. Angewandte Chemie (International Ed. in English). 54: 599-603. PMID 25327786 DOI: 10.1002/Anie.201408411 |
0.314 |
|
| 2015 |
Seenaiah M, Jbara M, Mali SM, Brik A. Convergent Versus Sequential Protein Synthesis: The Case of Ubiquitinated and Glycosylated H2B Angewandte Chemie - International Edition. 54: 12374-12378. DOI: 10.1002/anie.201503309 |
0.784 |
|
| 2014 |
Becker CF, Brik A, Dawson P, Hackenberger CP. Chemical protein synthesis. Journal of Peptide Science : An Official Publication of the European Peptide Society. 20: 63. PMID 25975419 DOI: 10.1002/Psc.2607 |
0.491 |
|
| 2014 |
Bondalapati S, Ruvinov E, Kryukov O, Cohen S, Brik A. Rapid End-Group Modification of Polysaccharides for Biomaterial Applications in Regenerative Medicine. Macromolecular Rapid Communications. PMID 25220432 DOI: 10.1002/Marc.201400354 |
0.373 |
|
| 2014 |
Jbara M, Seenaiah M, Brik A. Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein Chemical Communications. 50: 12534-12537. PMID 25196573 DOI: 10.1039/C4Cc06499B |
0.822 |
|
| 2014 |
Krutauz D, Reis N, Nakasone MA, Siman P, Zhang D, Kirkpatrick DS, Gygi SP, Brik A, Fushman D, Glickman MH. Extended ubiquitin species are protein-based DUB inhibitors. Nature Chemical Biology. 10: 664-70. PMID 24997605 DOI: 10.1038/Nchembio.1574 |
0.405 |
|
| 2014 |
Long L, Thelen JP, Furgason M, Haj-Yahya M, Brik A, Cheng D, Peng J, Yao T. The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination. The Journal of Biological Chemistry. 289: 8916-30. PMID 24526689 DOI: 10.1074/Jbc.M114.551754 |
0.428 |
|
| 2014 |
Hemantha HP, Bavikar SN, Herman-Bachinsky Y, Haj-Yahya N, Bondalapati S, Ciechanover A, Brik A. Nonenzymatic polyubiquitination of expressed proteins. Journal of the American Chemical Society. 136: 2665-73. PMID 24437386 DOI: 10.1021/Ja412594D |
0.46 |
|
| 2014 |
Haj-Yahya N, Hemantha HP, Meledin R, Bondalapati S, Seenaiah M, Brik A. Dehydroalanine-based diubiquitin activity probes Organic Letters. 16: 540-543. PMID 24364494 DOI: 10.1021/Ol403416W |
0.342 |
|
| 2013 |
Haj-Yahya M, Fauvet B, Herman-Bachinsky Y, Hejjaoui M, Bavikar SN, Karthikeyan SV, Ciechanover A, Lashuel HA, Brik A. Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology. Proceedings of the National Academy of Sciences of the United States of America. 110: 17726-31. PMID 24043770 DOI: 10.1073/Pnas.1315654110 |
0.376 |
|
| 2013 |
Haj-Yahya N, Haj-Yahya M, Castañeda CA, Spasser L, Hemantha HP, Jbara M, Penner M, Ciechanover A, Fushman D, Brik A. Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins. Angewandte Chemie (International Ed. in English). 52: 11149-53. PMID 24006204 DOI: 10.1002/Anie.201306118 |
0.791 |
|
| 2013 |
Fauvet B, Butterfield SM, Fuks J, Brik A, Lashuel HA. One-pot total chemical synthesis of human α-synuclein. Chemical Communications (Cambridge, England). 49: 9254-6. PMID 23995579 DOI: 10.1039/C3Cc45353G |
0.453 |
|
| 2013 |
Shema-Yaacoby E, Nikolov M, Haj-Yahya M, Siman P, Allemand E, Yamaguchi Y, Muchardt C, Urlaub H, Brik A, Oren M, Fischle W. Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription. Cell Reports. 4: 601-8. PMID 23933260 DOI: 10.1016/J.Celrep.2013.07.014 |
0.45 |
|
| 2013 |
Siman P, Karthikeyan SV, Nikolov M, Fischle W, Brik A. Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34. Angewandte Chemie (International Ed. in English). 52: 8059-63. PMID 23794525 DOI: 10.1002/Anie.201303844 |
0.52 |
|
| 2013 |
Brik A. Chemistry and biology of peptides, proteins and beyond Bioorganic and Medicinal Chemistry. 21: 3398-3399. PMID 23706510 DOI: 10.1016/J.Bmc.2013.05.020 |
0.442 |
|
| 2013 |
Hemantha HP, Brik A. Non-enzymatic synthesis of ubiquitin chains: Where chemistry makes a difference Bioorganic and Medicinal Chemistry. 21: 3411-3420. PMID 23465437 DOI: 10.1016/J.Bmc.2013.02.004 |
0.449 |
|
| 2013 |
Meledin R, Brik A, Aharoni A. Dissecting the Roles of the N- and C-Flanking Residues of Acetyllysine Substrates for SIRT1 Activity Chembiochem. 14: 577-581. PMID 23426869 DOI: 10.1002/Cbic.201200727 |
0.399 |
|
| 2013 |
Moyal T, Hemantha HP, Siman P, Refua M, Brik A. Highly efficient one-pot ligation and desulfurization Chemical Science. 4: 2496-2501. DOI: 10.1039/C3Sc50239B |
0.518 |
|
| 2012 |
Moyal T, Bavikar SN, Karthikeyan SV, Hemantha HP, Brik A. Polymerization behavior of a bifunctional ubiquitin monomer as a function of the nucleophile site and folding conditions. Journal of the American Chemical Society. 134: 16085-92. PMID 22963682 DOI: 10.1021/Ja3078736 |
0.445 |
|
| 2012 |
Shabek N, Herman-Bachinsky Y, Buchsbaum S, Lewinson O, Haj-Yahya M, Hejjaoui M, Lashuel HA, Sommer T, Brik A, Ciechanover A. The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation. Molecular Cell. 48: 87-97. PMID 22902562 DOI: 10.1016/J.Molcel.2012.07.011 |
0.398 |
|
| 2012 |
Spasser L, Brik A. Chemistry and biology of the ubiquitin signal Angewandte Chemie - International Edition. 51: 6840-6862. PMID 22696461 DOI: 10.1002/Anie.201200020 |
0.376 |
|
| 2012 |
Fuchs G, Shema E, Vesterman R, Kotler E, Wolchinsky Z, Wilder S, Golomb L, Pribluda A, Zhang F, Haj-Yahya M, Feldmesser E, Brik A, Yu X, Hanna J, Aberdam D, et al. RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. Molecular Cell. 46: 662-73. PMID 22681888 DOI: 10.1016/J.Molcel.2012.05.023 |
0.337 |
|
| 2012 |
Siman P, Brik A. Chemical and semisynthesis of posttranslationally modified proteins Organic and Biomolecular Chemistry. 10: 5684-5697. PMID 22527305 DOI: 10.1039/C2Ob25149C |
0.504 |
|
| 2012 |
Siman P, Karthikeyan SV, Brik A. Native chemical ligation at glutamine. Organic Letters. 14: 1520-3. PMID 22360701 DOI: 10.1021/Ol300254Y |
0.462 |
|
| 2012 |
Ohayon S, Spasser L, Aharoni A, Brik A. Targeting deubiquitinases enabled by chemical synthesis of proteins. Journal of the American Chemical Society. 134: 3281-9. PMID 22279964 DOI: 10.1021/Ja2116712 |
0.456 |
|
| 2012 |
Bavikar SN, Spasser L, Haj-Yahya M, Karthikeyan SV, Moyal T, Kumar KS, Brik A. Chemical synthesis of ubiquitinated peptides with varying lengths and types of ubiquitin chains to explore the activity of deubiquitinases. Angewandte Chemie (International Ed. in English). 51: 758-63. PMID 22131237 DOI: 10.1002/Anie.201106430 |
0.4 |
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| 2011 |
Castañeda CA, Spasser L, Bavikar SN, Brik A, Fushman D. Segmental isotopic labeling of ubiquitin chains to unravel monomer-specific molecular behavior. Angewandte Chemie (International Ed. in English). 50: 11210-4. PMID 21957015 DOI: 10.1002/Anie.201104649 |
0.365 |
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| 2011 |
Zeytuni N, Ozyamak E, Ben-Harush K, Davidov G, Levin M, Gat Y, Moyal T, Brik A, Komeili A, Zarivach R. Self-recognition mechanism of MamA, a magnetosome-associated TPR-containing protein, promotes complex assembly. Proceedings of the National Academy of Sciences of the United States of America. 108: E480-7. PMID 21784982 DOI: 10.1073/Pnas.1103367108 |
0.415 |
|
| 2011 |
Kumar KS, Bavikar SN, Spasser L, Moyal T, Ohayon S, Brik A. Total chemical synthesis of a 304 amino acid K48-linked tetraubiquitin protein. Angewandte Chemie (International Ed. in English). 50: 6137-41. PMID 21591043 DOI: 10.1002/Anie.201101920 |
0.385 |
|
| 2011 |
Siman P, Blatt O, Moyal T, Danieli T, Lebendiker M, Lashuel HA, Friedler A, Brik A. Chemical synthesis and expression of the HIV-1 Rev protein. Chembiochem : a European Journal of Chemical Biology. 12: 1097-104. PMID 21488138 DOI: 10.1002/Cbic.201100033 |
0.436 |
|
| 2011 |
Spasser L, Ajish Kumar KS, Brik A. Scope and limitation of side-chain assisted ligation Journal of Peptide Science. 17: 252-255. PMID 21391285 DOI: 10.1002/Psc.1336 |
0.375 |
|
| 2011 |
Kumar KS, Spasser L, Ohayon S, Erlich LA, Brik A. Expeditious chemical synthesis of ubiquitinated peptides employing orthogonal protection and native chemical ligation. Bioconjugate Chemistry. 22: 137-43. PMID 21235224 DOI: 10.1021/Bc1004735 |
0.53 |
|
| 2011 |
Brik A, Dawson PE, Kent SBH. Guest editorial: Chemical protein synthesis Israel Journal of Chemistry. 51: 852-853. DOI: 10.1002/Ijch.201100087 |
0.493 |
|
| 2011 |
Kumar KSA, Brik A. δ-mercaptolysine assisted ubiquitination Israel Journal of Chemistry. 51: 900-907. DOI: 10.1002/Ijch.201100073 |
0.487 |
|
| 2010 |
Kumar KSA, Brik A. Accessing posttranslationally modified proteins through thiol positioning Journal of Peptide Science. 16: 524-529. PMID 20862719 DOI: 10.1002/Psc.1229 |
0.531 |
|
| 2010 |
Kumar KSA, Spasser L, Erlich LA, Bavikar SN, Brik A. Total chemical synthesis of di-ubiquitin chains Angewandte Chemie - International Edition. 49: 9126-9131. PMID 20815002 DOI: 10.1002/Anie.201003763 |
0.353 |
|
| 2010 |
Haj-Yahya M, Ajish Kumar KS, Erlich LA, Brik A. Protecting group variations of delta-mercaptolysine useful in chemical ubiquitylation Biopolymers. 94: 504-510. PMID 20564006 DOI: 10.1002/Bip.21384 |
0.44 |
|
| 2010 |
Erlich LA, Kumar KS, Haj-Yahya M, Dawson PE, Brik A. N-methylcysteine-mediated total chemical synthesis of ubiquitin thioester. Organic & Biomolecular Chemistry. 8: 2392-6. PMID 20448897 DOI: 10.1039/C000332H |
0.514 |
|
| 2010 |
Harpaz Z, Siman P, Ajish Kumar KS, Brik A. Protein synthesis assisted by native chemical ligation at leucine Chembiochem. 11: 1232-1235+1158. PMID 20437446 DOI: 10.1002/Cbic.201000168 |
0.484 |
|
| 2009 |
Ajish Kumar KS, Haj-Yahya M, Olschewski D, Lashuel HA, Brik A. Highly efficient and chemoselective peptide ubiquitylation. Angewandte Chemie (International Ed. in English). 48: 8090-4. PMID 19780082 DOI: 10.1002/Anie.200902936 |
0.45 |
|
| 2009 |
Ajish Kumar KS, Harpaz Z, Haj-Yahya M, Brik A. Side-chain assisted ligation in protein synthesis Bioorganic and Medicinal Chemistry Letters. 19: 3870-3874. PMID 19376701 DOI: 10.1016/J.Bmcl.2009.03.156 |
0.438 |
|
| 2008 |
Nepomniaschiy N, Grimminger V, Cohen A, DiGiovanni S, Lashuel HA, Brik A. Switch peptide via Staudinger reaction. Organic Letters. 10: 5243-6. PMID 18959426 DOI: 10.1021/Ol802268E |
0.352 |
|
| 2008 |
Bennett CS, Dean SM, Payne RJ, Ficht S, Brik A, Wong CH. Sugar-assisted glycopeptide ligation with complex oligosaccharides: scope and limitations. Journal of the American Chemical Society. 130: 11945-52. PMID 18698778 DOI: 10.1021/Ja8010513 |
0.347 |
|
| 2008 |
Lutsky MY, Nepomniaschiy N, Brik A. Peptide ligation via side-chain auxiliary Chemical Communications. 1229-1231. PMID 18309426 DOI: 10.1039/B718945A |
0.358 |
|
| 2008 |
Brik A. Metathesis in peptides and peptidomimetics Advanced Synthesis and Catalysis. 350: 1161-1675. DOI: 10.1002/Adsc.200800149 |
0.411 |
|
| 2007 |
Payne RJ, Ficht S, Tang S, Brik A, Yang YY, Case DA, Wong CH. Extended sugar-assisted glycopeptide ligations: development, scope, and applications. Journal of the American Chemical Society. 129: 13527-36. PMID 17935327 DOI: 10.1021/Ja073653P |
0.397 |
|
| 2007 |
Ficht S, Payne RJ, Brik A, Wong CH. Second-generation sugar-assisted ligation: a method for the synthesis of cysteine-containing glycopeptides. Angewandte Chemie (International Ed. in English). 46: 5975-9. PMID 17607677 DOI: 10.1002/Anie.200700546 |
0.36 |
|
| 2007 |
Yang YY, Ficht S, Brik A, Wong CH. Sugar-assisted ligation in glycoprotein synthesis Journal of the American Chemical Society. 129: 7690-7701. PMID 17523644 DOI: 10.1021/Ja0708971 |
0.412 |
|
| 2007 |
Brik A, Wong CH. Sugar-assisted ligation for the synthesis of glycopeptides Chemistry - a European Journal. 13: 5670-5675. PMID 17508364 DOI: 10.1002/Chem.200700330 |
0.444 |
|
| 2006 |
Brik A, Ficht S, Yang YY, Bennett CS, Wong CH. Sugar-assisted ligation of N-linked glycopeptides with broad sequence tolerance at the ligation junction. Journal of the American Chemical Society. 128: 15026-33. PMID 17105315 DOI: 10.1021/Ja065601Q |
0.418 |
|
| 2006 |
Brik A, Ficht S, Wong CH. Strategies for the preparation of homogenous glycoproteins Current Opinion in Chemical Biology. 10: 638-644. PMID 17046315 DOI: 10.1016/J.Cbpa.2006.10.003 |
0.413 |
|
| 2006 |
Brik A, Yang YY, Ficht S, Wong CH. Sugar-assisted glycopeptide ligation. Journal of the American Chemical Society. 128: 5626-7. PMID 16637616 DOI: 10.1021/Ja061165W |
0.457 |
|
| 2006 |
Brik A, Wu CY, Wong CH. Microtiter plate based chemistry and in situ screening: A useful approach for rapid inhibitor discovery Organic and Biomolecular Chemistry. 4: 1446-1457. PMID 16604207 DOI: 10.1039/B600055J |
0.343 |
|
| 2006 |
Liang FS, Brik A, Lin YC, Elder JH, Wong CH. Epoxide opening in water and screening in situ for rapid discovery of enzyme inhibitors in microtiter plates. Bioorganic & Medicinal Chemistry. 14: 1058-62. PMID 16275107 DOI: 10.1016/J.Bmc.2005.09.026 |
0.349 |
|
| 2005 |
Wu CY, Brik A, Wang SK, Chen YH, Wong CH. Tetrabutylammonium fluoride-mediated rapid alkylation reaction in microtiter plates for the discovery of enzyme inhibitors in situ Chembiochem. 6: 2176-2180. PMID 16270365 DOI: 10.1002/Cbic.200500295 |
0.33 |
|
| 2005 |
Brik A, Wu CY, Best MD, Wong CH. Tetrabutylammonium fluoride-assisted rapid N9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ Bioorganic and Medicinal Chemistry. 13: 4622-4626. PMID 15953729 DOI: 10.1016/J.Bmc.2005.02.066 |
0.37 |
|
| 2005 |
Brik A, Alexandratos J, Lin YC, Elder JH, Olson AJ, Wlodawer A, Goodsell DS, Wong CH. 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors. Chembiochem : a European Journal of Chemical Biology. 6: 1167-9. PMID 15934050 DOI: 10.1002/Cbic.200500101 |
0.344 |
|
| 2005 |
Brik A, Alexandratos J, Lin Y, Elder JH, Olson AJ, Wlodawer A, Goodsell DS, Wong C. Cover Picture: 1,2,3-Triazole as a Peptide Surrogate in the Rapid Synthesis of HIV-1 Protease Inhibitors (ChemBioChem 7/2005) Chembiochem. 6: 1137-1137. DOI: 10.1002/Cbic.200590021 |
0.338 |
|
| 2003 |
Brik A, Muldoon J, Lin YC, Elder JH, Goodsell DS, Olson AJ, Fokin VV, Sharpless KB, Wong CH. Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors. Chembiochem : a European Journal of Chemical Biology. 4: 1246-8. PMID 14613121 DOI: 10.1002/Cbic.200300724 |
0.342 |
|
| 2002 |
Brik A, Dawson PE, Keinan E. The product of the natural reaction catalyzed by 4-oxalocrotonate tautomerase becomes an affinity label of its mutant. Bioorganic & Medicinal Chemistry. 10: 3891-7. PMID 12413840 DOI: 10.1016/S0968-0896(02)00385-1 |
0.337 |
|
| 2002 |
Brik A, D'Souza LJ, Keinan E, Grynszpan F, Dawson PE. Mutants of 4-oxalocrotonate tautomerase catalyze the decarboxylation of oxaloacetate through an imine mechanism. Chembiochem : a European Journal of Chemical Biology. 3: 845-51. PMID 12210985 DOI: 10.1002/1439-7633(20020902)3:9<845::Aid-Cbic845>3.0.Co;2-2 |
0.303 |
|
| 2002 |
Brik A, Lin YC, Elder J, Wong CH. A quick diversity-oriented amide-forming reaction to optimize p-subsite residues of HIV protease inhibitors Chemistry and Biology. 9: 891-896. PMID 12204688 DOI: 10.1016/S1074-5521(02)00184-9 |
0.333 |
|
| 2002 |
Brik A, D'Souza LJ, Keinan E, Grynszpan F, Dawson PE. Cover Picture: ChemBioChem 9/2002 Chembiochem. 3: 799-799. DOI: 10.1002/1439-7633(20020902)3:9<799::Aid-Cbic799>3.0.Co;2-7 |
0.323 |
|
| 2000 |
Brik A, Keinan E, Dawson PE. Protein synthesis by solid-phase chemical ligation using a safety catch linker Journal of Organic Chemistry. 65: 3829-3835. PMID 10864771 DOI: 10.1021/Jo000346S |
0.535 |
|
| 1997 |
Haddad N, Brik A, Grishko M. Studies towards total synthesis of borrelidin, regioselective methylation of bis-epoxides and structure determination Tetrahedron Letters. 38: 6079-6082. DOI: 10.1016/S0040-4039(97)01372-5 |
0.317 |
|
| 1997 |
Haddad N, Grishko M, Brik A. Studies towards total synthesis of borrelidin, stereoselective synthesis of the polysubstituted macrolidic part Tetrahedron Letters. 38: 6075-6078. DOI: 10.1016/S0040-4039(97)01371-3 |
0.367 |
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