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High-probability grants
According to our matching algorithm, Tatjana Piotrowski is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2005 — 2008 |
Piotrowski, Tatjana |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Zebrafish as a Model to Study Glia and Neuron Development
Tatjana Piotrowski No.0519462 Zebrafish as a model to study glia and neuron development
The goal of the laboratory is to identify cell-cell interactions during sensory organ formation using zebrafish. As an experimental system, the lateral line of the zebrafish was chosen based on (1) the accessibility of the sensory organs to direct observation and manipulation; (2) the similarity between lateral line hair cells and hair cells in the inner ear; and (3) the genetic tools available in zebrafish to identify genes involved in sensory organ formation. So far, 20 mutants affecting different aspects of lateral line development have been identified. Several mutants are particularly interesting because they possess 'extra' sensory organs on their trunk, and lack glia along the posterior lateral line nerve. Historically, glial cells have been thought to be merely support cells for neurons, but recent studies have shown that glia play a much more important role in nervous system development. Analyses of one of these mutants allowed the PI to make a fundamentally new observation relevant to glia-neuron interactions: the identification of a key role for glia in controlling hair cell differentiation. The goals of this study are to reinvestigate normal lateral line development and to characterize the other lateral line mutants that possess extra neuromasts (sensory organs) to determine how glia and neurons interact in sensory organ formation. Results from these experiments are likely to reveal genetic interactions important for sensory organ formation. The genetic interactions discovered in the zebrafish lateral line are very likely to be applicable to basic developmental processes involved in the formation of other organs, in zebrafish as well as in other vertebrates. This project involves training opportunities for graduate and undergraduate students. The systematic analyses of the cell labeling experiments will be a good entry point for novice researchers to learn how to design, perform and critically evaluate experiments. Thus, it is expected that students will be able to generate data of sufficient significance to merit presentations of their work in seminars, conferences, and publications.
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2009 — 2010 |
Piotrowski, Tatjana Sanchez Alvarado, Alejandro (co-PI) [⬀] |
RC1Activity Code Description: NIH Challenge Grants in Health and Science Research |
Analysis of Hair Cell Regeneration in Zebrafish
DESCRIPTION (provided by applicant): A prominent cause of deafness is loss of hair cells due to age, noise or antibiotic treatments. In contrast to mammalian hair cells, fish, bird and amphibian hair cells are constantly turning over and regenerate following hair cell death. The aim is to take advantage of the lateral line of zebrafish to define and characterize the molecular and cellular interactions occurring during hair cell regeneration with the long-term goal of activating these pathways in mammals. To uncover the mechanisms driving hair cell regeneration, the lateral line of the zebrafish was chosen as an experimental paradigm because of 1) the ability of zebrafish support cells to regenerate hair cells;2) the functional and morphological similarity between the lateral line hair cells and the hair cells of the inner ear;3) its accessibility to direct observation and manipulation throughout development;and 4) the ability to rapidly and cost-effectively isolate specific cell types involved in hair cell regeneration, experiments that are difficult to perform in the classical model systems, e.g., mouse and chick. The two laboratories are pursuing the following strategy to identify the earliest genes that are transcribed in support cells subsequent to hair cell death. First, the location and population dynamics of stem cells and surrounding niche cells in normal and regenerating neuromasts will be determined, which is essential for determining the signals required for stem cell maintenance and activation. Secondly, the transcriptome of purified support cells will be defined using microarray analyses. To systematically analyze all candidate genes identified, a novel and powerful bioinformatics approach will be employed to identify genes co-regulated by the same transcription factors. Identifying these important transcription factors will be crucial for our understanding of how regeneration is triggered in lower vertebrates. Combined, these two approaches will discover key hair cell regeneration genes and set the stage for a systematic dissection of this complex problem to inform the development of therapeutics to regenerate hair cells in mammals. PUBLIC HEALTH RELEVANCE: Stem cells are crucial for adult tissue homeostasis and regeneration. The zebrafish lateral line is an excellent model to elucidate the genetic pathways controlling stem cells and sensory hair cell regeneration. Results from our studies will aid in the identification of stem cells in the mammalian ear and in the development of therapeutic strategies to regenerate hair cells in mammals.
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