Joshua W. Little, Ph.D.

2011 Anatomy Saint Louis University, St. Louis, MO, United States 
Neuroscience Biology, Behavioral Sciences Psychology, Pharmacology
"Joshua Little"


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Daniela Salvemini grad student 2011 Saint Louis University
 (The key role of peroxynitrite in supraspinal nociceptive modulation during pathophysiological pain.)
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Stockstill K, Doyle TM, Yan X, et al. (2018) Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain. The Journal of Experimental Medicine
Touchette JC, Little JW, Wilken GH, et al. (2018) The neurotoxin DSP-4 induces hyperalgesia in rats that is accompanied by spinal oxidative stress and cytokine production. Neuroscience
Wahlman C, Doyle TM, Little JW, et al. (2018) Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels via astrocyte-dependent mechanisms. Pain
Reed WR, Cranston JT, Onifer SM, et al. (2017) Decreased spontaneous activity and altered evoked nociceptive response of rat thalamic submedius neurons to lumbar vertebra thrust. Experimental Brain Research
Reed WR, Pickar JG, Sozio RS, et al. (2017) Characteristics of Paraspinal Muscle Spindle Response to Mechanically Assisted Spinal Manipulation: A Preliminary Report. Journal of Manipulative and Physiological Therapeutics
Little JW, Grieve TJ, Cramer GD, et al. (2015) Grading Osteoarthritic Changes of the Zygapophyseal Joints from Radiographs: A Reliability Study. Journal of Manipulative and Physiological Therapeutics. 38: 344-51
Ford A, Castonguay A, Cottet M, et al. (2015) Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6057-67
Little JW, Ford A, Symons-Liguori AM, et al. (2015) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain : a Journal of Neurology. 138: 28-35
Janes K, Wahlman C, Little JW, et al. (2015) Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy. Brain, Behavior, and Immunity. 44: 91-9
Janes K, Little JW, Li C, et al. (2014) The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. The Journal of Biological Chemistry. 289: 21082-97
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