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Fraser A. Hof, Ph.D. - Publications

Affiliations: 
1998-2003 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
 2005- Chemistry University of Victoria, Victoria, British Columbia, Canada 
Area:
molecular recognition and self-assembling systems
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62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 King D, Wilson CR, Herron L, Deng CL, Mehdi S, Tiwary P, Hof F, Isaacs L. Molecular recognition of methylated amino acids and peptides by Pillar[6]MaxQ. Organic & Biomolecular Chemistry. PMID 36097881 DOI: 10.1039/d2ob01487d  0.51
2021 Warmerdam Z, Kamba BE, Le MH, Schrader T, Isaacs L, Bayer P, Hof F. Binding Methylarginines and Methyllysines as Free Amino Acids: A Comparative Study of Multiple Host Classes. Chembiochem : a European Journal of Chemical Biology. 23: e202100502. PMID 34758178 DOI: 10.1002/cbic.202100502  0.561
2021 Shaurya A, Garnett GAE, Starke MJ, Grasdal MC, Dewar CC, Kliuchynskyi AY, Hof F. An easily accessible, lower rim substituted calix[4]arene selectively binds ,-dimethyllysine. Organic & Biomolecular Chemistry. 19: 4691-4696. PMID 33978657 DOI: 10.1039/d1ob00524c  0.777
2021 Beatty MA, Hof F. Host-guest binding in water, salty water, and biofluids: general lessons for synthetic, bio-targeted molecular recognition. Chemical Society Reviews. PMID 33651047 DOI: 10.1039/d0cs00495b  0.598
2019 Milosevich N, McFarlane J, Gignac MC, Li J, Brown TM, Wilson CR, Devorkin L, Croft CS, Hof R, Paci I, Lum JJ, Hof F. Pan-specific and partially selective dye-labeled peptidic inhibitors of the polycomb paralog proteins. Bioorganic & Medicinal Chemistry. 115176. PMID 31753799 DOI: 10.1016/J.Bmc.2019.115176  0.376
2019 Beatty MA, Selinger AJ, Li Y, Hof F. Parallel Synthesis and Screening of Supramolecular Chemosensors that Achieve Fluorescent Turn-On Detection of Drugs in Saliva. Journal of the American Chemical Society. PMID 31577900 DOI: 10.1021/Jacs.9B07073  0.604
2019 Simhadri C, Daze KD, Douglas SF, Milosevich N, Monjas L, Dev A, Brown TM, Hirsch AKH, Wulff JE, Hof F. Rational adaptation of L3MBTL1 inhibitors to create small-molecule Cbx7 antagonists. Chemmedchem. PMID 31254321 DOI: 10.1002/Cmdc.201900021  0.357
2019 Beatty MA, Pye AT, Shaurya A, Kim B, Selinger AJ, Hof F. Using reversible non-covalent and covalent bonds to create assemblies and equilibrating molecular networks that survive 5 molar urea. Organic & Biomolecular Chemistry. PMID 30698579 DOI: 10.1039/C8Ob02909A  0.76
2019 Beatty MA, Busmann JA, Fagen NG, Garnett GAE, Hof F. A clip-like host that undergoes self-assembly and competitive guest-induced disassembly in water Supramolecular Chemistry. 31: 101-107. DOI: 10.1080/10610278.2018.1494275  0.356
2018 Beatty MA, Borges-González J, Sinclair NJ, Pye AT, Hof F. Analyte-driven disassembly and turn-on fluorescent sensing in competitive biological media. Journal of the American Chemical Society. PMID 29461821 DOI: 10.1021/Jacs.7B13298  0.646
2017 Traoré M, Gignac M, Doan ND, Hof F, Lubell WD. Aza-amino acid scanning of chromobox homolog 7 (CBX7) ligands. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 28220557 DOI: 10.1002/Psc.2982  0.321
2016 Milosevich N, Warmerdam Z, Hof F. Structural aspects of small-molecule inhibition of methyllysine reader proteins. Future Medicinal Chemistry. 8: 1681-1702. PMID 27577975 DOI: 10.4155/Fmc-2016-0082  0.358
2016 Hof F. Host–guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents Chemical Communications. 52: 10093-10108. PMID 27374270 DOI: 10.1039/C6Cc04771H  0.378
2016 Milosevich N, Gignac MC, McFarlane J, Simhadri C, Horvath S, Daze KD, Croft CS, Dheri A, Quon TT, Douglas SF, Wulff JE, Paci I, Hof F. Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family. Acs Medicinal Chemistry Letters. 7: 139-44. PMID 26985288 DOI: 10.1021/Acsmedchemlett.5B00378  0.374
2016 Garnett GA, Starke MJ, Shaurya A, Li J, Hof F. Supramolecular Affinity Chromatography for Methylation-Targeted Proteomics. Analytical Chemistry. 88: 3697-703. PMID 26973166 DOI: 10.1021/Acs.Analchem.5B04508  0.759
2016 Garnett GA, Daze KD, Peña Diaz JA, Fagen N, Shaurya A, Ma MC, Collins MS, Johnson DW, Zakharov LN, Hof F. Attraction by repulsion: compounds with like charges undergo self-assembly in water that improves in high salt and persists in real biological fluids. Chemical Communications (Cambridge, England). PMID 26762538 DOI: 10.1039/C5Cc10527G  0.76
2015 Ali M, Daze KD, Strongin DE, Rothbart SB, Rincon-Arano H, Allen HF, Li J, Strahl BD, Hof F, Kutateladze TG. Molecular insight into inhibition of the methylated histone-plant homeodomain complexes by calixarenes. The Journal of Biological Chemistry. PMID 26229108 DOI: 10.1074/Jbc.M115.669333  0.347
2015 McGovern RE, Snarr BD, Lyons JA, McFarlane J, Whiting AL, Paci I, Hof F, Crowley PB. Structural study of a small molecule receptor bound to dimethyllysine in lysozyme. Chemical Science (Royal Society of Chemistry : 2010). 6: 442-449. PMID 25530835 DOI: 10.1039/C4Sc02383H  0.786
2014 Simhadri C, Daze KD, Douglas SF, Quon TT, Dev A, Gignac MC, Peng F, Heller M, Boulanger MJ, Wulff JE, Hof F. Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7). Journal of Medicinal Chemistry. 57: 2874-83. PMID 24625057 DOI: 10.1021/Jm401487X  0.362
2014 Allen HF, Daze KD, Shimbo T, Lai A, Musselman CA, Sims JK, Wade PA, Hof F, Kutateladze TG. Inhibition of histone binding by supramolecular hosts. The Biochemical Journal. 459: 505-12. PMID 24576085 DOI: 10.1042/Bj20140145  0.371
2014 Wang X, Post J, Hore DK, Hof F. Minimalist synthetic host with stacked guanidinium ions mimics the weakened hydration shells of protein-protein interaction interfaces. The Journal of Organic Chemistry. 79: 34-40. PMID 24328280 DOI: 10.1021/Jo401949S  0.429
2014 Shaurya A, Dubicki KI, Hof F. Chemical agents for binding post-translationally methylated lysines and arginines Supramolecular Chemistry. 26: 583-590. DOI: 10.1080/10610278.2013.872786  0.762
2013 Tabet S, Douglas SF, Daze KD, Garnett GA, Allen KJ, Abrioux EM, Quon TT, Wulff JE, Hof F. Synthetic trimethyllysine receptors that bind histone 3, trimethyllysine 27 (H3K27me3) and disrupt its interaction with the epigenetic reader protein CBX7. Bioorganic & Medicinal Chemistry. 21: 7004-10. PMID 24100156 DOI: 10.1016/J.Bmc.2013.09.024  0.374
2013 Pinter T, Simhadri C, Hof F. Dissecting the complex recognition interfaces of potent tetrazole- and pyrrole-based anion binders. Journal of Organic Chemistry. 78: 4642-4648. PMID 23631741 DOI: 10.1021/Jo400372C  0.424
2013 Daze KD, Hof F. The cation-π interaction at protein-protein interaction interfaces: developing and learning from synthetic mimics of proteins that bind methylated lysines. Accounts of Chemical Research. 46: 937-945. PMID 22724379 DOI: 10.1021/Ar300072G  0.343
2013 Whiting AL, Dubicki KI, Hof F. Synthesis of Versatile Nonsymmetric Amine‐ and Boron‐Functionalized Tröger's Base Derivatives, Including a Tröger's Base Amino Acid European Journal of Organic Chemistry. 2013: 6802-6810. DOI: 10.1002/Ejoc.201300992  0.751
2012 Whiting AL, Hof F. Binding trimethyllysine and other cationic guests in water with a series of indole-derived hosts: large differences in affinity from subtle changes in structure. Organic & Biomolecular Chemistry. 10: 6885-92. PMID 22828995 DOI: 10.1039/C2Ob25882J  0.782
2012 Murray JI, Tonkin ML, Whiting AL, Peng F, Farnell B, Cullen JT, Hof F, Boulanger MJ. Structural characterization of S100A15 reveals a novel zinc coordination site among S100 proteins and altered surface chemistry with functional implications for receptor binding. Bmc Structural Biology. 12: 16. PMID 22747601 DOI: 10.1186/1472-6807-12-16  0.757
2012 Wang X, Hof F. (How) does 1,3,5-triethylbenzene scaffolding work? Analyzing the abilities of 1,3,5-triethylbenzene- and 1,3,5-trimethylbenzene-based scaffolds to preorganize the binding elements of supramolecular hosts and to improve binding of targets. Beilstein Journal of Organic Chemistry. 8: 1-10. PMID 22423267 DOI: 10.3762/Bjoc.8.1  0.372
2012 Daze KD, Ma MCF, Pineux F, Hof F. Synthesis of new trisulfonated calix[4]arenes functionalized at the upper rim, and their complexation with the trimethyllysine epigenetic mark. Organic Letters. 14: 1512-1515. PMID 22397706 DOI: 10.1021/Ol300243B  0.395
2012 Jana S, Whiting AL, Hazra A, Sen S, Goswami S, Mehta G, Fun H, Hof F. Anion recognition by a family of quinoline-functionalised bis-amide hosts in solid state and in solution Supramolecular Chemistry. 24: 385-391. DOI: 10.1080/10610278.2012.676179  0.787
2012 Daze KD, Pinter T, Beshara CS, Ibraheem A, Minaker SA, Ma MCF, Courtemanche RJM, Campbell RE, Hof F. Supramolecular hosts that recognize methyllysines and disrupt the interaction between a modified histone tail and its epigenetic reader protein Chemical Science. 3: 2695-2699. DOI: 10.1039/C2Sc20583A  0.39
2011 Courtemanche RJ, Pinter T, Hof F. Just add tetrazole: 5-(2-pyrrolo)tetrazoles are simple, highly potent anion recognition elements. Chemical Communications (Cambridge, England). 47: 12688-90. PMID 22038194 DOI: 10.1039/C1Cc15875A  0.352
2011 Pinter T, Jana S, Courtemanche RJ, Hof F. Recognition properties of carboxylic acid bioisosteres: anion binding by tetrazoles, aryl sulfonamides, and acyl sulfonamides on a calix[4]arene scaffold. The Journal of Organic Chemistry. 76: 3733-41. PMID 21462934 DOI: 10.1021/Jo200031U  0.39
2010 Beshara CS, Jones CE, Daze KD, Lilgert BJ, Hof F. A simple calixarene recognizes post-translationally methylated lysine. Chembiochem : a European Journal of Chemical Biology. 11: 63-6. PMID 19937593 DOI: 10.1002/Cbic.200900633  0.301
2009 West NR, Farnell B, Murray JI, Hof F, Watson PH, Boulanger MJ. Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding. Protein Science : a Publication of the Protein Society. 18: 2615-23. PMID 19844956 DOI: 10.1002/Pro.274  0.328
2009 León R, Murray JI, Cragg G, Farnell B, West NR, Pace TC, Watson PH, Bohne C, Boulanger MJ, Hof F. Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways. Biochemistry. 48: 10591-600. PMID 19810752 DOI: 10.1021/Bi901330G  0.378
2009 Whiting AL, Neufeld NM, Hof F. A tryptophan-analog host whose interactions with ammonium ions in water are dominated by the hydrophobic effect Tetrahedron Letters. 50: 7035-7037. DOI: 10.1016/J.Tetlet.2009.09.161  0.776
2009 Zürcher M, Hof F, Barandun L, Schütz A, Schweizer WB, Meyer S, Bur D, Diederich F. Synthesis ofexo-3-Amino-7-azabicyclo[2.2.1]heptanes as a Class of Malarial Aspartic Protease Inhibitors: Exploration of Two Binding Pockets European Journal of Organic Chemistry. 2009: 1707-1719. DOI: 10.1002/Ejoc.200801184  0.484
2008 McKie AH, Friedland S, Hof F. Tetrazoles are potent anion recognition elements that emulate the disfavored anti conformations of carboxylic acids. Organic Letters. 10: 4653-4655. PMID 18816055 DOI: 10.1021/Ol801943U  0.375
2008 McQuinn K, McIndoe JS, Hof F. Insights into the post-translational methylation of arginine from studies of guanidinium-water nanodroplets. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 6483-9. PMID 18546445 DOI: 10.1002/Chem.200800101  0.331
2008 Wang X, Sarycheva OV, Koivisto BD, McKie AH, Hof F. A terphenyl scaffold for pi-stacked guanidinium recognition elements. Organic Letters. 10: 297-300. PMID 18092794 DOI: 10.1021/Ol7027042  0.381
2007 Mahnke DJ, McDonald R, Hof F. A shape-dependent hydrophobic effect for tetrazoles Chemical Communications. 3738-3740. PMID 17851612 DOI: 10.1039/B705256A  0.336
2006 Hof F, Schütz A, Fäh C, Meyer S, Bur D, Liu J, Goldberg DE, Diederich F. Starving the malaria parasite: inhibitors active against the aspartic proteases plasmepsins I, II, and IV. Angewandte Chemie (International Ed. in English). 45: 2138-41. PMID 16502446 DOI: 10.1002/Anie.200504119  0.391
2006 Berryman OB, Hof F, Hynes MJ, Johnson DW. Anion-pi interaction augments halide binding in solution. Chemical Communications (Cambridge, England). 506-8. PMID 16432564 DOI: 10.1039/B511570A  0.72
2006 Hof F, Schütz A, Fäh C, Meyer S, Bur D, Liu J, Goldberg DE, Diederich F. Aushungern des Malaria-Erregers: Hemmer der Aspartylproteasen Plasmepsin I, II und IV Angewandte Chemie. 118: 2193-2196. DOI: 10.1002/Ange.200504119  0.368
2005 Hof F, Scofield DM, Schweizer WB, Diederich F. A weak attractive interaction between organic fluorine and an amide group. Angewandte Chemie (International Ed. in English). 43: 5056-9. PMID 15384111 DOI: 10.1002/Anie.200460781  0.422
2005 Hof F, Schär M, Scofield DM, Fischer F, Diederich F, Sergeyev S. Preparation of Tröger base derivatives by cross-coupling methodologies Helvetica Chimica Acta. 88: 2333-2344. DOI: 10.1002/Hlca.200590168  0.615
2004 Biros SM, Ullrich EC, Hof F, Trembleau L, Rebek J. Kinetically stable complexes in water: the role of hydration and hydrophobicity. Journal of the American Chemical Society. 126: 2870-6. PMID 14995204 DOI: 10.1021/Ja038823M  0.689
2004 Hof F, Diederich F. Medicinal chemistry in academia: molecular recognition with biological receptors. Chemical Communications (Cambridge, England). 477-80. PMID 14973570 DOI: 10.1039/B314081B  0.404
2003 Johnson DW, Hof F, Palmer LC, Martín T, Obst U, Rebek J. Glycoluril ribbons tethered by complementary hydrogen bonds. Chemical Communications (Cambridge, England). 1638-9. PMID 12877479 DOI: 10.1039/B303508E  0.757
2002 Hof F, Craig SL, Nuckolls C, Rebek J. Molecular encapsulation. Angewandte Chemie (International Ed. in English). 41: 1488-508. PMID 19750648 DOI: 10.1002/1521-3773(20020503)41:9<1488::AID-ANIE1488>3.0.CO;2-G  0.617
2002 Johnson DW, Palmer LC, Hof F, Iovine PM, Rebek J. New supramolecular organization for a glycoluril: chiral hydrogen-bonded ribbons. Chemical Communications (Cambridge, England). 2228-9. PMID 12397991 DOI: 10.1039/B206648C  0.766
2002 Johnson DW, Hof F, Iovine PM, Nuckolls C, Rebek J. Solid-state and solution studies of a tetrameric capsule and its guests. Angewandte Chemie (International Ed. in English). 41: 3793-6. PMID 12386850 DOI: 10.1002/1521-3773(20021018)41:20<3793::Aid-Anie3793>3.0.Co;2-A  0.627
2002 Hof F, Rebek J. Molecules within molecules: Recognition through self-assembly Proceedings of the National Academy of Sciences of the United States of America. 99: 4775-4777. PMID 11880604 DOI: 10.1073/Pnas.042663699  0.334
2002 Hof F, Craig SL, Nuckolls C, Rebek Jr. J. Cover Picture: Angew. Chem. Int. Ed. 9/2002 Angewandte Chemie International Edition. 41: 1447-1447. DOI: 10.1002/1521-3773(20020503)41:9<1447::Aid-Anie1447>3.0.Co;2-U  0.572
2002 Hof F, Craig SL, Nuckolls C, Rebek Jr. J. Titelbild: Angew. Chem. 9/2002 Angewandte Chemie. 114: 1513-1513. DOI: 10.1002/1521-3757(20020503)114:9<1513::Aid-Ange1513>3.0.Co;2-1  0.579
2001 Hof F, Iovine PM, Johnson DW, Rebek J. Highly Selective Synthesis of Heterosubstituted Aromatic Sulfamides Organic Letters. 3: 4247-4249. PMID 11784189 DOI: 10.1021/Ol0169731  0.496
2001 Hof F, Palmer LC, Rebek J. Synthesis and Self-Assembly of the "Tennis Ball" Dimer and Subsequent Encapsulation of Methane. An Advanced Organic Chemistry Laboratory Experiment Journal of Chemical Education. 78: 1519. DOI: 10.1021/Ed078P1519  0.761
2000 Hof F, Nuckolls C, Craig SL, Martin T, Rebek J. Emergent conformational preferences of a self-assembling small molecule: Structure and dynamics in a tetrameric capsule Journal of the American Chemical Society. 122: 10991-10996. DOI: 10.1021/Ja002340Q  0.67
2000 Hof F, Nuckolls C, Rebek J. Diversity and selection in self-assembled tetrameric capsules [20] Journal of the American Chemical Society. 122: 4251-4252. DOI: 10.1021/Ja0005136  0.516
1999 Nuckolls C, Hof F, Martín T, Rebek J. Chiral Microenvironments in Self-Assembled Capsules Journal of the American Chemical Society. 121: 10281-10285. DOI: 10.1021/Ja992779M  0.572
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