| Year |
Citation |
Score |
| 2023 |
Tian J, Boggs DG, Donnan PH, Barroso GT, Garcia AA, Dowling DP, Buss JA, Bridwell-Rabb J. The NADH recycling enzymes TsaC and TsaD regenerate reducing equivalents for Rieske oxygenase chemistry. The Journal of Biological Chemistry. 105222. PMID 37673337 DOI: 10.1016/j.jbc.2023.105222 |
0.735 |
|
| 2022 |
Gnann AD, Marincin K, Frueh DP, Dowling DP. Dynamics and mechanistic interpretations of nonribosomal peptide synthetase cyclization domains. Current Opinion in Chemical Biology. 72: 102228. PMID 36402006 DOI: 10.1016/j.cbpa.2022.102228 |
0.716 |
|
| 2022 |
Gnann AD, Xia Y, Soule J, Barthélemy C, Mawani JS, Musoke SN, Castellano BM, Brignole EJ, Frueh DP, Dowling DP. High-resolution structures of a siderophore-producing cyclization domain from Yersinia pestis offer a refined proposal of substrate binding. The Journal of Biological Chemistry. 102454. PMID 36063993 DOI: 10.1016/j.jbc.2022.102454 |
0.746 |
|
| 2021 |
Lee YJ, Dai N, Müller SI, Guan C, Parker MJ, Fraser ME, Walsh SE, Sridar J, Mulholland A, Nayak K, Sun Z, Lin YC, Comb DG, Marks K, Gonzalez R, ... Dowling DP, et al. Pathways of thymidine hypermodification. Nucleic Acids Research. PMID 34522950 DOI: 10.1093/nar/gkab781 |
0.625 |
|
| 2021 |
Liew JJM, El Saudi I, Nguyen SV, Wicht DK, Dowling DP. Structures of the alkanesulfonate monooxygenase MsuD provide insight into C-S bond cleavage, substrate scope, and an unexpected role for the tetramer. The Journal of Biological Chemistry. 100823. PMID 34029591 DOI: 10.1016/j.jbc.2021.100823 |
0.317 |
|
| 2019 |
Soule J, Gnann AD, Gonzalez R, Parker MJ, McKenna KC, Nguyen SV, Phan NT, Wicht DK, Dowling DP. Structure and function of the two-component flavin-dependent methanesulfinate monooxygenase within bacterial sulfur assimilation. Biochemical and Biophysical Research Communications. PMID 31753487 DOI: 10.1016/J.Bbrc.2019.11.008 |
0.704 |
|
| 2018 |
Grell TAJ, Bell BN, Nguyen C, Dowling DP, Bruender NA, Bandarian V, Drennan CL. Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity. Protein Science : a Publication of the Protein Society. PMID 30341796 DOI: 10.2210/Pdb6Nhl/Pdb |
0.643 |
|
| 2017 |
Bruender NA, Grell TA, Dowling DP, McCarty RM, Drennan CL, Bandarian V. 7-Carboxy-7-deazaguanine synthase - A radical S-adenosyl-L-methionine enzyme with polar tendencies. Journal of the American Chemical Society. PMID 28045519 DOI: 10.1021/Jacs.6B11381 |
0.599 |
|
| 2016 |
Dowling DP, Kung Y, Croft AK, Taghizadeh K, Kelly WL, Walsh CT, Drennan CL. Structural elements of an NRPS cyclization domain and its intermodule docking domain. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791103 DOI: 10.1073/Pnas.1608615113 |
0.735 |
|
| 2016 |
Dowling DP, Miles ZD, Köhrer C, Maiocco SJ, Elliott SJ, Bandarian V, Drennan CL. Molecular basis of cobalamin-dependent RNA modification. Nucleic Acids Research. PMID 27638883 DOI: 10.1093/Nar/Gkw806 |
0.613 |
|
| 2014 |
Dowling DP, Bruender NA, Young AP, McCarty RM, Bandarian V, Drennan CL. Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism. Nature Chemical Biology. 10: 106-12. PMID 24362703 DOI: 10.1038/Nchembio.1426 |
0.632 |
|
| 2012 |
Dowling DP, Vey JL, Croft AK, Drennan CL. Structural diversity in the AdoMet radical enzyme superfamily. Biochimica Et Biophysica Acta. 1824: 1178-95. PMID 22579873 DOI: 10.1016/J.Bbapap.2012.04.006 |
0.629 |
|
| 2012 |
Dowling DP, Croft AK, Drennan CL. Radical use of Rossmann and TIM barrel architectures for controlling coenzyme B12 chemistry. Annual Review of Biophysics. 41: 403-27. PMID 22577824 DOI: 10.1146/Annurev-Biophys-050511-102225 |
0.603 |
|
| 2011 |
Ilies M, Dowling DP, Lombardi PM, Christianson DW. Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8. Bioorganic & Medicinal Chemistry Letters. 21: 5854-8. PMID 21875805 DOI: 10.1016/J.Bmcl.2011.07.100 |
0.761 |
|
| 2011 |
Lombardi PM, Cole KE, Dowling DP, Christianson DW. Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes. Current Opinion in Structural Biology. 21: 735-43. PMID 21872466 DOI: 10.1016/J.Sbi.2011.08.004 |
0.737 |
|
| 2011 |
Cole KE, Dowling DP, Boone MA, Phillips AJ, Christianson DW. Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. Journal of the American Chemical Society. 133: 12474-7. PMID 21790156 DOI: 10.1021/Ja205972N |
0.764 |
|
| 2011 |
Ilies M, Di Costanzo L, Dowling DP, Thorn KJ, Christianson DW. Binding of α,α-disubstituted amino acids to arginase suggests new avenues for inhibitor design. Journal of Medicinal Chemistry. 54: 5432-43. PMID 21728378 DOI: 10.1021/Jm200443B |
0.602 |
|
| 2010 |
Dowling DP, Gattis SG, Fierke CA, Christianson DW. Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function . Biochemistry. 49: 5048-56. PMID 20545365 DOI: 10.1021/Bi1005046 |
0.577 |
|
| 2010 |
Dowling DP, Ilies M, Olszewski KL, Portugal S, Mota MM, Llinás M, Christianson DW. Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection . Biochemistry. 49: 5600-8. PMID 20527960 DOI: 10.1021/Bi100390Z |
0.609 |
|
| 2008 |
Dowling DP, Gantt SL, Gattis SG, Fierke CA, Christianson DW. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry. 47: 13554-63. PMID 19053282 DOI: 10.1021/Bi801610C |
0.65 |
|
| 2008 |
Dowling DP, Di Costanzo L, Gennadios HA, Christianson DW. Evolution of the arginase fold and functional diversity. Cellular and Molecular Life Sciences : Cmls. 65: 2039-55. PMID 18360740 DOI: 10.1007/S00018-008-7554-Z |
0.729 |
|
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