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Farshid Guilak, Ph.D. - Publications

Affiliations: 
Orthopaedic Surgery Washington University School of medicine in Saint Louis 
Area:
biomechanics, mechanobiology, regenerative medicine, osteoarthritis, biomedical engineering
Website:
https://orthopaedicresearch.wustl.edu/labs/farshid-guilak/
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Year Citation  Score
2024 Melrose J, Guilak F. Diverse and multifunctional roles for perlecan () in repair of the intervertebral disc. Jor Spine. 7: e1362. PMID 39081381 DOI: 10.1002/jsp2.1362  0.33
2024 Nims R, Palmer DR, Kassab J, Zhang B, Guilak F. The chondrocyte "mechanome": Activation of the mechanosensitive ion channels TRPV4 and PIEZO1 drives unique transcriptional signatures. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 38: e23778. PMID 38959010 DOI: 10.1096/fj.202400883R  0.707
2024 Klimak M, Cimino A, Lenz K, Springer L, Collins K, Harasymowicz N, Xu N, Pham C, Guilak F. Engineered Self-Regulating Macrophages for Targeted Anti-inflammatory Drug Delivery. Research Square. PMID 38854124 DOI: 10.21203/rs.3.rs-4385938/v1  0.68
2024 Shen KC, Collins KH, Ferey JLA, Fappi A, McCormick JJ, Mittendorfer B, Guilak F, Meyer GA. Excess Intramyocellular Lipid Does Not Affect Muscle Fiber Biophysical Properties in Mice or People with Metabolically Abnormal Obesity. Diabetes. PMID 38701374 DOI: 10.2337/db23-0991  0.627
2023 Jenkins TL, Sarmiento Huertas PA, Umemori K, Guilak F, Little D. Tendon-derived matrix crosslinking techniques for electrospun multi-layered scaffolds. Journal of Biomedical Materials Research. Part A. PMID 37489733 DOI: 10.1002/jbm.a.37588  0.665
2023 Savadipour A, Nims RJ, Rashidi N, Garcia-Castorena JM, Tang R, Marushack GK, Oswald SJ, Liedtke WB, Guilak F. Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes. Proceedings of the National Academy of Sciences of the United States of America. 120: e2221958120. PMID 37459546 DOI: 10.1073/pnas.2221958120  0.769
2023 Collins KH, Pferdehirt L, Saleh LS, Savadipour A, Springer LE, Lenz KL, Thompson DM, Oswald SJ, Pham CTN, Guilak F. Hydrogel Encapsulation of Genome-Engineered Stem Cells for Long-Term Self-Regulating Anti-Cytokine Therapy. Gels (Basel, Switzerland). 9. PMID 36826339 DOI: 10.3390/gels9020169  0.684
2023 Dicks AR, Maksaev GI, Harissa Z, Savadipour A, Tang R, Steward N, Liedtke W, Nichols CG, Wu CL, Guilak F. Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes. Elife. 12. PMID 36810131 DOI: 10.7554/eLife.71154  0.751
2023 Xie S, Choudhari S, Wu CL, Abramson K, Corcoran D, Gregory SG, Thimmapuram J, Guilak F, Little D. Aging and obesity prime the methylome and transcriptome of adipose stem cells for disease and dysfunction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 37: e22785. PMID 36794668 DOI: 10.1096/fj.202201413R  0.762
2023 Savadipour A, Palmer D, Ely EV, Collins KH, Garcia-Castorena JM, Harissa Z, Kim YS, Oestreich A, Qu F, Rashidi N, Guilak F. The Role of PIEZO Ion Channels in the Musculoskeletal System. American Journal of Physiology. Cell Physiology. PMID 36717101 DOI: 10.1152/ajpcell.00544.2022  0.678
2022 Dicks AR, Steward N, Guilak F, Wu CL. Chondrogenic Differentiation of Human-Induced Pluripotent Stem Cells. Methods in Molecular Biology (Clifton, N.J.). 2598: 87-114. PMID 36355287 DOI: 10.1007/978-1-0716-2839-3_8  0.717
2022 Kim YS, Guilak F. Engineering Hyaluronic Acid for the Development of New Treatment Strategies for Osteoarthritis. International Journal of Molecular Sciences. 23. PMID 35955795 DOI: 10.3390/ijms23158662  0.324
2022 Collins KH, Gui C, Ely EV, Lenz KL, Harris CA, Guilak F, Meyer GA. Leptin mediates the regulation of muscle mass and strength by adipose tissue. The Journal of Physiology. PMID 35844058 DOI: 10.1113/JP283034  0.652
2021 Guilak F, Estes BT, Moutos FT. Functional tissue engineering of articular cartilage for biological joint resurfacing-The 2021 Elizabeth Winston Lanier Kappa Delta Award. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 34812518 DOI: 10.1002/jor.25223  0.827
2021 Nims RJ, Pferdehirt L, Guilak F. Mechanogenetics: harnessing mechanobiology for cellular engineering. Current Opinion in Biotechnology. 73: 374-379. PMID 34735987 DOI: 10.1016/j.copbio.2021.09.011  0.709
2021 Estes BT, Enomoto M, Moutos FT, Carson MA, Toth JM, Eggert P, Stallrich J, Willard VP, Veis DJ, Little D, Guilak F, Lascelles BDX. Biological resurfacing in a canine model of hip osteoarthritis. Science Advances. 7: eabi5918. PMID 34524840 DOI: 10.1126/sciadv.abi5918  0.781
2021 Choi YR, Collins KH, Springer LE, Pferdehirt L, Ross AK, Wu CL, Moutos FT, Harasymowicz NS, Brunger JM, Pham CTN, Guilak F. A genome-engineered bioartificial implant for autoregulated anticytokine drug delivery. Science Advances. 7: eabj1414. PMID 34516920 DOI: 10.1126/sciadv.abj1414  0.763
2021 Willard VP, Leddy HA, Palmer D, Wu CL, Liedtke W, Guilak F. Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis. Stem Cells (Dayton, Ohio). PMID 34427363 DOI: 10.1002/stem.3440  0.822
2021 Collins KH, Schwartz DJ, Lenz KL, Harris CA, Guilak F. Taxonomic changes in the gut microbiota are associated with cartilage damage independent of adiposity, high fat diet, and joint injury. Scientific Reports. 11: 14560. PMID 34267289 DOI: 10.1038/s41598-021-94125-4  0.67
2021 Rodríguez Ruiz A, Dicks A, Tuerlings M, Schepers K, van Pel M, Nelissen RGHH, Freund C, Mummery CL, Orlova V, Guilak F, Meulenbelt I, Ramos YFM. Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells. Cell and Tissue Research. PMID 34241697 DOI: 10.1007/s00441-021-03498-5  0.334
2021 Klimak M, Nims RJ, Pferdehirt L, Collins KH, Harasymowicz NS, Oswald SJ, Setton LA, Guilak F. Immunoengineering the next generation of arthritis therapies. Acta Biomaterialia. PMID 33823324 DOI: 10.1016/j.actbio.2021.03.062  0.795
2021 Lee W, Nims RJ, Savadipour A, Zhang Q, Leddy HA, Liu F, McNulty AL, Chen Y, Guilak F, Liedtke WB. Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33758095 DOI: 10.1073/pnas.2001611118  0.813
2021 Nims RJ, Pferdehirt L, Ho NB, Savadipour A, Lorentz J, Sohi S, Kassab J, Ross AK, O'Conor CJ, Liedtke WB, Zhang B, McNulty AL, Guilak F. A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues. Science Advances. 7. PMID 33571125 DOI: 10.1126/sciadv.abd9858  0.807
2021 Harasymowicz NS, Rashidi N, Savadipour A, Wu CL, Tang R, Bramley J, Buchser W, Guilak F. Single-cell RNA sequencing reveals the induction of novel myeloid and myeloid-associated cell populations in visceral fat with long-term obesity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21417. PMID 33566380 DOI: 10.1096/fj.202001970R  0.685
2021 Rai MF, Wu CL, Capellini TD, Guilak F, Dicks AR, Muthuirulan P, Grandi F, Bhutani N, Westendorf JJ. Single Cell Omics for Musculoskeletal Research. Current Osteoporosis Reports. PMID 33559841 DOI: 10.1007/s11914-021-00662-2  0.692
2021 Savadipour A, Nims RJ, Katz DB, Guilak F. Regulation of chondrocyte biosynthetic activity by dynamic hydrostatic pressure: the role of TRP channels. Connective Tissue Research. 1-13. PMID 33494617 DOI: 10.1080/03008207.2020.1871475  0.698
2021 Collins KH, Lenz KL, Pollitt EN, Ferguson D, Hutson I, Springer LE, Oestreich AK, Tang R, Choi YR, Meyer GA, Teitelbaum SL, Pham CTN, Harris CA, Guilak F. Adipose tissue is a critical regulator of osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33443201 DOI: 10.1073/pnas.2021096118  0.697
2021 Wu CL, Dicks A, Steward N, Tang R, Katz DB, Choi YR, Guilak F. Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis. Nature Communications. 12: 362. PMID 33441552 DOI: 10.1038/s41467-020-20598-y  0.7
2020 Vovos TJ, Furman BD, Huebner JL, Kimmerling KA, Utturkar GM, Green CL, Kraus VB, Guilak F, Olson SA. Initial Displacement of the Intra-Articular Surface after Articular Fracture Correlates with PTA in C57BL/6 mice but Not 'Superhealer' MRL/MpJ Mice. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 33179316 DOI: 10.1002/jor.24912  0.696
2020 Katz DB, Huynh NPT, Savadipour A, Palte I, Guilak F. An immortalized human adipose-derived stem cell line with highly enhanced chondrogenic properties. Biochemical and Biophysical Research Communications. 530: 252-258. PMID 32828295 DOI: 10.1016/J.Bbrc.2020.07.016  0.437
2020 Oestreich AK, Collins KH, Harasymowicz NS, Wu CL, Guilak F. Is Obesity a Disease of Stem Cells? Cell Stem Cell. 27: 15-18. PMID 32619511 DOI: 10.1016/J.Stem.2020.04.019  0.791
2020 Qu F, Palte IC, Gontarz PM, Zhang B, Guilak F. Transcriptomic analysis of bone and fibrous tissue morphogenesis during digit tip regeneration in the adult mouse. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32506623 DOI: 10.1096/Fj.202000330R  0.383
2020 Tang R, Harasymowicz NS, Wu CL, Collins KH, Choi YR, Oswald SJ, Guilak F. Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet-induced obesity. Science Advances. 6: eaaz7492. PMID 32426485 DOI: 10.1126/Sciadv.Aaz7492  0.791
2020 Kimmerling KA, Oswald SJ, Huebner JL, Little D, Kraus VB, Kang JX, Wu CL, Guilak F. Transgenic conversion of ω-6 to ω-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis. Arthritis Research & Therapy. 22: 83. PMID 32295649 DOI: 10.1186/S13075-020-02170-7  0.77
2020 Huynh NP, Gloss CC, Lorentz J, Tang R, Brunger JM, McAlinden A, Zhang B, Guilak F. Long non-coding RNA enhances chondrogenesis via suppression of interferon type II signaling pathway. Elife. 9. PMID 32202492 DOI: 10.7554/Elife.49558  0.749
2020 Dicks A, Wu CL, Steward N, Adkar SS, Gersbach CA, Guilak F. Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter. Stem Cell Research & Therapy. 11: 66. PMID 32070421 DOI: 10.1186/S13287-020-01597-8  0.742
2020 Bailey KN, Furman BD, Zeitlin J, Kimmerling KA, Wu CL, Guilak F, Olson SA. Intra-articular Depletion of Macrophages Increases Acute Synovitis and Alters Macrophage Polarity in the Injured Mouse Knee. Osteoarthritis and Cartilage. PMID 32044353 DOI: 10.1016/J.Joca.2020.01.015  0.785
2020 Wu CL, Harasymowicz NS, Klimak MA, Collins KH, Guilak F. The Role of Macrophages in Osteoarthritis and Cartilage Repair. Osteoarthritis and Cartilage. PMID 31926267 DOI: 10.1016/J.Joca.2019.12.007  0.812
2019 Kelly NH, Huynh NPT, Guilak F. Single cell RNA-sequencing reveals cellular heterogeneity and trajectories of lineage specification during murine embryonic limb development. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 31874220 DOI: 10.1016/J.Matbio.2019.12.004  0.695
2019 Yan H, Duan X, Collins KH, Springer LE, Guilak F, Wickline SA, Rai MF, Pan H, Pham CTN. Nanotherapy Targeting NF-κB Attenuates Acute Pain After Joint Injury. Precision Nanomedicine. 2: 245-248. PMID 31681908 DOI: 10.33218/prnano2(1).181129.1  0.65
2019 Harasymowicz NS, Choi YR, Wu CL, Iannucci L, Tang R, Guilak F. Intergenerational transmission of diet-induced obesity, metabolic imbalance, and osteoarthritis in mice. Arthritis & Rheumatology (Hoboken, N.J.). PMID 31646754 DOI: 10.1002/Art.41147  0.669
2019 Arrigoni P, Ruprecht JC, Chasse DAD, Glass KA, Andress B, Guilak F, Weinberg JB, McNulty AL. Optimization of Meniscus Cell Transduction Using Lentivirus and Adeno-Associated Virus for Gene Editing and Tissue Engineering Applications. Cartilage. 1947603519880321. PMID 31609141 DOI: 10.1177/1947603519880321  0.769
2019 Guang Y, McGrath TM, Klug N, Nims R, Shih CC, Bayguinov PO, Guilak F, Pham CTN, Fitzpatrick JAJ, Setton LA. Combined Experimental Approach and Finite Element Modeling of Small Molecule Transport Through Joint Synovium to Measure Effective Diffusivity. Journal of Biomechanical Engineering. PMID 31536113 DOI: 10.1115/1.4044892  0.755
2019 Choi YR, Collins KH, Lee JW, Kang HJ, Guilak F. Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs. Tissue Engineering and Regenerative Medicine. 16: 335-343. PMID 31413938 DOI: 10.1007/S13770-018-0172-4  0.7
2019 Shen H, Yoneda S, Abu-Amer Y, Guilak F, Gelberman RH. Stem Cell-Derived Extracellular Vesicles Attenuate the Early Inflammatory Response after Tendon Injury and Repair. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 31286564 DOI: 10.1002/Jor.24406  0.356
2019 Ruprecht JC, Waanders TD, Rowland CR, Nishimuta JF, Glass KA, Stencel J, DeFrate LE, Guilak F, Weinberg JB, McNulty AL. Meniscus-Derived Matrix Scaffolds Promote the Integrative Repair of Meniscal Defects. Scientific Reports. 9: 8719. PMID 31213610 DOI: 10.1038/S41598-019-44855-3  0.831
2019 Larson BL, Yu SN, Park H, Estes BT, Moutos FT, Bloomquist CJ, Wu PB, Welter JF, Langer R, Guilak F, Freed LE. Chondrogenic, hypertrophic, and osteochondral differentiation of human mesenchymal stem cells on three-dimensionally woven scaffolds. Journal of Tissue Engineering and Regenerative Medicine. PMID 31115161 DOI: 10.1002/Term.2899  0.812
2019 Guilak F, Sandell L, Huard J. Journal of Orthopaedic Research: Special Issue on Stem Cells. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 31050013 DOI: 10.1002/Jor.24338  0.338
2019 Guilak F, Pferdehirt L, Ross AK, Choi YR, Collins KH, Nims RJ, Katz DB, Klimak M, Tabbaa S, Pham CT. Designer stem cells: Genome engineering and the next generation of cell-based therapies. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 30977548 DOI: 10.1002/Jor.24304  0.819
2019 Pferdehirt L, Ross AK, Brunger JM, Guilak F. A Synthetic Gene Circuit for Self-Regulating Delivery of Biologic Drugs in Engineered Tissues. Tissue Engineering. Part A. PMID 30968743 DOI: 10.1089/Ten.Tea.2019.0027  0.761
2019 Gilchrist CL, Leddy HA, Kaye L, Case ND, Rothenberg KE, Little D, Liedtke W, Hoffman BD, Guilak F. TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension. Proceedings of the National Academy of Sciences of the United States of America. PMID 30674675 DOI: 10.1073/Pnas.1811095116  0.805
2019 Harasymowicz NS, Dicks A, Wu CL, Guilak F. Physiologic and pathologic effects of dietary free fatty acids on cells of the joint. Annals of the New York Academy of Sciences. PMID 30648276 DOI: 10.1111/Nyas.13999  0.715
2019 Votava L, Schwartz AG, Harasymowicz NS, Wu CL, Guilak F. The effects of dietary fatty acid content on humeral cartilage and bone structure in a mouse model of diet-induced obesity. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 30644575 DOI: 10.1002/Jor.24219  0.78
2019 Qu F, Guilak F, Mauck RL. Cell migration: implications for repair and regeneration in joint disease. Nature Reviews. Rheumatology. PMID 30617265 DOI: 10.1038/S41584-018-0151-0  0.436
2018 Adkar SS, Wu CL, Willard VP, Dicks A, Ettyreddy A, Steward N, Bhutani N, Gersbach CA, Guilak F. Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing. Stem Cells (Dayton, Ohio). PMID 30378731 DOI: 10.1002/Stem.2931  0.817
2018 Collins AT, Kulvaranon ML, Cutcliffe HC, Utturkar GM, Smith WAR, Spritzer CE, Guilak F, DeFrate LE. Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI. Arthritis Research & Therapy. 20: 232. PMID 30333058 DOI: 10.1186/S13075-018-1727-4  0.327
2018 Collins AT, Hatcher CC, Kim SY, Ziemian SN, Spritzer CE, Guilak F, DeFrate LE, McNulty AL. Selective Enzymatic Digestion of Proteoglycans and Collagens Alters Cartilage T1rho and T2 Relaxation Times. Annals of Biomedical Engineering. PMID 30288634 DOI: 10.1007/S10439-018-02143-7  0.33
2018 Moffat KL, Goon K, Moutos FT, Estes BT, Oswald SJ, Zhao X, Guilak F. Composite Cellularized Structures Created from an Interpenetrating Polymer Network Hydrogel Reinforced by a 3D Woven Scaffold. Macromolecular Bioscience. e1800140. PMID 30040175 DOI: 10.1002/Mabi.201800140  0.816
2018 Huynh NPT, Zhang B, Guilak F. High-depth transcriptomic profiling reveals the temporal gene signature of human mesenchymal stem cells during chondrogenesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800534R. PMID 29985644 DOI: 10.1096/Fj.201800534R  0.371
2018 Rowland CR, Glass KA, Ettyreddy AR, Gloss CC, Matthews JRL, Huynh NPT, Guilak F. Regulation of decellularized tissue remodeling via scaffold-mediated lentiviral delivery in anatomically-shaped osteochondral constructs. Biomaterials. 177: 161-175. PMID 29894913 DOI: 10.1016/J.Biomaterials.2018.04.049  0.824
2018 Guilak F, Nims R, Dicks A, Wu CL, Meulenbelt I. Osteoarthritis as a disease of the cartilage pericellular matrix. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 29800616 DOI: 10.1016/J.Matbio.2018.05.008  0.816
2018 Martin JT, Gullbrand SE, Fields AJ, Purmessur D, Diwan AD, Oxland TR, Chiba K, Guilak F, Hoyland JA, Iatridis JC. Publication trends in spine research from 2007 to 2016: Comparison of the Orthopaedic Research Society Spine Section and the International Society for the Study of the Lumbar Spine. Jor Spine. 1: e1006. PMID 29770804 DOI: 10.1002/jsp2.1006  0.695
2018 Huynh NPT, Brunger JM, Gloss CC, Moutos FT, Gersbach CA, Guilak F. Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3DWoven Scaffold. Tissue Engineering. Part A. PMID 29756533 DOI: 10.1089/Ten.Tea.2017.0510  0.83
2018 Venkatesan JK, Moutos FT, Rey-Rico A, Estes BT, Frisch J, Schmitt G, Madry H, Guilak F, Cucchiarini M. Chondrogenic Differentiation Processes in Human Bone Marrow Aspirates Seeded in Three-Dimensional Woven Poly(ε-Caprolactone) Scaffolds Enhanced by rAAV-Mediated SOX9 Gene Transfer. Human Gene Therapy. PMID 29717624 DOI: 10.1089/Hum.2017.165  0.81
2018 Tang R, Jing L, Willard VP, Wu CL, Guilak F, Chen J, Setton LA. Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells. Stem Cell Research & Therapy. 9: 61. PMID 29523190 DOI: 10.1186/S13287-018-0797-1  0.802
2018 Rai M, Cai L, Chinzei N, Yousuf O, Guilak F, Brophy R. Pattern of synovial fluid cytokine biomarkers in the knee after anterior cruciate ligament tear suggests an initial repair response Osteoarthritis and Cartilage. 26: S188. DOI: 10.1016/J.Joca.2018.02.403  0.307
2017 Pascual-Garrido C, Guilak F, Rai MF, Harris MD, Lopez MJ, Todhunter RJ, Clohisy JC. The dog is a model for the study of human hip dysplasia. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 29227567 DOI: 10.1002/Jor.23828  0.305
2017 Cao C, Ren Y, Barnett AS, Mirando AJ, Rouse D, Mun SH, Park-Min KH, McNulty AL, Guilak F, Karner CM, Hilton MJ, Pitt GS. Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss. Jci Insight. 2. PMID 29202453 DOI: 10.1172/Jci.Insight.95512  0.309
2017 Furman BD, Kent CL, Huebner JL, Kraus VB, McNulty AL, Guilak F, Olson SA. CXCL10 is Upregulated in Synovium and Cartilage following Articular Fracture. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 28906016 DOI: 10.1002/Jor.23735  0.393
2017 Adkar SS, Brunger JM, Willard VP, Wu CL, Gersbach CA, Guilak F. Genome Engineering for Personalized Arthritis Therapeutics. Trends in Molecular Medicine. PMID 28887050 DOI: 10.1016/J.Molmed.2017.08.002  0.788
2017 Lee W, Guilak F, Liedtke W. Role of Piezo Channels in Joint Health and Injury. Current Topics in Membranes. 79: 263-273. PMID 28728820 DOI: 10.1016/Bs.Ctm.2016.10.003  0.804
2017 Wu CL, McNeill J, Goon K, Little D, Kimmerling K, Huebner J, Kraus V, Guilak F. Conditional macrophage depletion increases inflammation and does not inhibit the development of osteoarthritis in obese MaFIA mice. Arthritis & Rheumatology (Hoboken, N.J.). PMID 28544542 DOI: 10.1002/Art.40161  0.776
2017 Brunger JM, Zutshi A, Willard VP, Gersbach CA, Guilak F. Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs. Stem Cell Reports. PMID 28457885 DOI: 10.1016/J.Stemcr.2017.03.022  0.8
2017 Bridgen DT, Fearing BV, Jing L, Sanchez-Adams J, Cohan MC, Guilak F, Chen J, Setton LA. Regulation of Human Nucleus Pulposus Cells by Peptide-Coupled Substrates. Acta Biomaterialia. PMID 28433788 DOI: 10.1016/J.Actbio.2017.04.019  0.783
2017 Friedman JM, Sennett ML, Bonadio MB, Orji KO, Neuwirth AL, Keah N, Carey JL, Moutos FT, Estes BT, Guilak F, Madry H, Mauck RL, Dodge GR. Comparison of Fixation Techniques of 3D-Woven Poly(ϵ-Caprolactone) Scaffolds for Cartilage Repair in a Weightbearing Porcine Large Animal Model. Cartilage. 1947603517700953. PMID 28397530 DOI: 10.1177/1947603517700953  0.804
2017 Wu CL, Kimmerling KA, Little D, Guilak F. Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair. Scientific Reports. 7: 44315. PMID 28317846 DOI: 10.1038/Srep44315  0.784
2017 Rai MF, Stoddart MJ, Guilak F. Mechanical Signals as Regulators of Cartilage Degeneration and Regeneration. The Journal of the American Academy of Orthopaedic Surgeons. 25: e87-e89. PMID 28291148 DOI: 10.5435/Jaaos-D-16-00938  0.336
2017 Hatcher CC, Collins AT, Kim SY, Michel LC, Mostertz WC, Ziemian SN, Spritzer CE, Guilak F, DeFrate LE, McNulty AL. Relationship between T1rho magnetic resonance imaging, synovial fluid biomarkers, and the biochemical and biomechanical properties of cartilage. Journal of Biomechanics. PMID 28237185 DOI: 10.1016/J.Jbiomech.2017.02.001  0.358
2017 Farhang N, Brunger JM, Stover JD, Thakore PI, Lawrence B, Guilak F, Gersbach CA, Setton LA, Bowles RD. CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments. Tissue Engineering. Part A. PMID 28095751 DOI: 10.1089/Ten.Tea.2016.0441  0.785
2017 Furman B, Kimmerling K, Ramamoorthy S, Li Y, Wu Y, Huebner J, Guilak F, Kraus V, Olson S. Articular fracture upregulates lipid metabolites in human synovial fluid Osteoarthritis and Cartilage. 25: S381. DOI: 10.1016/J.Joca.2017.02.652  0.695
2017 Collins A, Kulvaranon M, Utturkar G, Spritzer C, Guilak F, Defrate L. In vivo biochemical and biomechanical properties of cartilage are affected by obesity. Osteoarthritis and Cartilage. 25: S112-S113. DOI: 10.1016/J.Joca.2017.02.181  0.314
2017 Huebner J, Furman B, Kimmerling K, Olson S, Guilak F, Kraus V. Identification of biomarkers indicative of synovitis in the mouse articular fracture model of PTA Osteoarthritis and Cartilage. 25: S104. DOI: 10.1016/J.Joca.2017.02.165  0.698
2017 Collins K, Tang R, Wu C, Guilak F. Gene therapy for follistatin decreases systemic inflammation and pain sensitivity following knee injury in high-fat diet induced obese mice Osteoarthritis and Cartilage. 25: S66. DOI: 10.1016/J.Joca.2017.02.119  0.677
2016 Recha-Sancho L, Moutos FT, Abellà J, Guilak F, Semino CE. Dedifferentiated Human Articular Chondrocytes Redifferentiate to a Cartilage-Like Tissue Phenotype in a Poly(ε-Caprolactone)/Self-Assembling Peptide Composite Scaffold. Materials (Basel, Switzerland). 9. PMID 28773609 DOI: 10.3390/Ma9060472  0.764
2016 Sakamoto Y, Buchanan RM, Adams JS, Guilak F, Sacks MS. MODELING THE FUNCTIONAL ROLE OF VALVE INTERSTITIAL CELL STRESS FIBERS. Journal of Biomechanical Engineering. PMID 28024085 DOI: 10.1115/1.4035557  0.312
2016 Liu B, Goode AP, Carter TE, Utturkar GM, Huebner JL, Taylor DC, Moorman Iii CT, Garrett WE, Kraus VB, Guilak F, DeFrate LE, McNulty AL. Matrix Metalloproteinase Activity and Prostaglandin E2 are Elevated in the Synovial Fluid of Meniscus Tear Patients. Connective Tissue Research. PMID 27813662 DOI: 10.1080/03008207.2016.1256391  0.325
2016 Brunger JM, Zutshi A, Willard VP, Gersbach CA, Guilak F. CRISPR/Cas9 editing of induced pluripotent stem cells for engineering inflammation-resistant tissues. Arthritis & Rheumatology (Hoboken, N.J.). PMID 27813286 DOI: 10.1002/Art.39982  0.818
2016 Little D, Johnson S, Hash J, Olson SA, Estes BT, Moutos FT, Lascelles BD, Guilak F. Functional outcome measures in a surgical model of hip osteoarthritis in dogs. Journal of Experimental Orthopaedics. 3: 17. PMID 27525982 DOI: 10.1186/S40634-016-0053-5  0.78
2016 Moutos FT, Glass KA, Compton SA, Ross AK, Gersbach CA, Guilak F, Estes BT. Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing. Proceedings of the National Academy of Sciences of the United States of America. PMID 27432980 DOI: 10.1073/Pnas.1601639113  0.819
2016 O'Conor CJ, Ramalingam S, Zelenski NA, Benefield HC, Rigo I, Little D, Wu CL, Chen D, Liedtke W, McNulty AL, Guilak F. Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis. Scientific Reports. 6: 29053. PMID 27388701 DOI: 10.1038/Srep29053  0.811
2016 Hwang PY, Jing L, Chen J, Lim FL, Tang R, Choi H, Cheung KM, Risbud MV, Gersbach CA, Guilak F, Leung VY, Setton LA. N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions. Scientific Reports. 6: 28038. PMID 27292569 DOI: 10.1038/Srep28038  0.56
2016 Huynh NP, Anderson B, Guilak F, McAlinden A. Emerging roles for long non-coding RNAs in skeletal biology and disease. Connective Tissue Research. PMID 27254479 DOI: 10.1080/03008207.2016.1194406  0.303
2016 Kanju P, Chen Y, Lee W, Yeo M, Lee SH, Romac J, Shahid R, Fan P, Gooden DM, Simon SA, Spasojevic I, Mook RA, Liddle RA, Guilak F, Liedtke WB. Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. Scientific Reports. 6: 26894. PMID 27247148 DOI: 10.1038/Srep26894  0.772
2016 Jayes FL, Liu B, Moutos FT, Kuchibhatla M, Guilak F, Leppert PC. Loss of Stiffness in Collagen-Rich Uterine Fibroids after Digestion with Purified Collagenase Clostridium Histolyticum. American Journal of Obstetrics and Gynecology. PMID 27177523 DOI: 10.1016/J.Ajog.2016.05.006  0.693
2016 Cucchiarini M, McNulty AL, Mauck RL, Setton LA, Guilak F, Madry H. Advances in combining gene therapy with cell and tissue engineering-based approaches to enhance healing of the meniscus. Osteoarthritis and Cartilage. 24: 1330-9. PMID 27063441 DOI: 10.1016/J.Joca.2016.03.018  0.375
2016 Rowland CR, Colucci LA, Guilak F. Fabrication of anatomically-shaped cartilage constructs using decellularized cartilage-derived matrix scaffolds. Biomaterials. 91: 57-72. PMID 26999455 DOI: 10.1016/J.Biomaterials.2016.03.012  0.813
2016 Lozoya OA, Gilchrist CL, Guilak F. Universally Conserved Relationships between Nuclear Shape and Cytoplasmic Mechanical Properties in Human Stem Cells. Scientific Reports. 6: 23047. PMID 26976044 DOI: 10.1038/Srep23047  0.782
2016 Glass KA, Rowland CR, Ettyreddy AR, Brunger JM, Huynh NP, Gersbach CA, Guilak F. 502. Biomaterial-Mediated Lentiviral Delivery of Anti-Inflammatory Genes in Cartilage-Derived Matrix Hemispheres Molecular Therapy. 24: S199-S200. DOI: 10.1016/S1525-0016(16)33311-1  0.802
2016 Adkar SS, Willard VP, Brunger JM, Shiao KT, Gersbach CA, Guilak F. 318. Targeted Genome Editing of Human Induced Pluripotent Stem Cells Using CRISPR/CAS9 to Generate a Knock-in Type II Collagen Reporter for the Purification of Chondrogenic Cells Molecular Therapy. 24: S128. DOI: 10.1016/S1525-0016(16)33127-6  0.806
2016 Huebner J, Furman B, Manson M, Kimmerling K, Olson S, Guilak F, DeFrate L, Zura R, Reilly R, Kraus V. Acute inflammatory response after severe joint injury potentially involved in the development of post-traumatic arthritis Osteoarthritis and Cartilage. 24: S79-S80. DOI: 10.1016/J.Joca.2016.01.169  0.712
2016 Wu C, Kimmerling K, Little D, Guilak F. Serum free fatty acid levels as predictors of the severity of obesity-associated osteoarthritis Osteoarthritis and Cartilage. 24: S58-S59. DOI: 10.1016/J.Joca.2016.01.128  0.763
2016 Lee W, Leddy H, McNulty A, Guilak F, Liedtke W. Inflammatory Cytokine Il-1α Up-Regulates Piezo1 and Hyper-Sensitizes Chondrocytes to Compression Biophysical Journal. 110: 349a. DOI: 10.1016/J.Bpj.2015.11.1878  0.806
2015 Orr SB, Chainani A, Hippensteel KJ, Kishan A, Gilchrist C, Garrigues NW, Ruch DS, Guilak F, Little D. Aligned multilayered electrospun scaffolds for rotator cuff tendon tissue engineering. Acta Biomaterialia. 24: 117-26. PMID 26079676 DOI: 10.1016/J.Actbio.2015.06.010  0.83
2015 Mellor LF, Mohiti-Asli M, Williams J, Kannan A, Dent MR, Guilak F, Loboa EG. Extracellular Calcium Modulates Chondrogenic and Osteogenic Differentiation of Human Adipose-Derived Stem Cells: A Novel Approach for Osteochondral Tissue Engineering Using a Single Stem Cell Source. Tissue Engineering. Part A. 21: 2323-33. PMID 26035347 DOI: 10.1089/Ten.Tea.2014.0572  0.356
2015 Hong S, Sycks D, Chan HF, Lin S, Lopez GP, Guilak F, Leong KW, Zhao X. 3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures. Advanced Materials (Deerfield Beach, Fla.). 27: 4035-40. PMID 26033288 DOI: 10.1002/Adma.201501099  0.301
2015 Christiansen BA, Guilak F, Lockwood KA, Olson SA, Pitsillides AA, Sandell LJ, Silva MJ, van der Meulen MC, Haudenschild DR. Non-invasive mouse models of post-traumatic osteoarthritis. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 23: 1627-38. PMID 26003950 DOI: 10.1016/J.Joca.2015.05.009  0.624
2015 Olson SA, Furman BD, Kraus VB, Huebner JL, Guilak F. Therapeutic opportunities to prevent post-traumatic arthritis: Lessons from the natural history of arthritis after articular fracture. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 25939531 DOI: 10.1002/Jor.22940  0.305
2015 Carter TE, Taylor KA, Spritzer CE, Utturkar GM, Taylor DC, Moorman CT, Garrett WE, Guilak F, McNulty AL, DeFrate LE. In vivo cartilage strain increases following medial meniscal tear and correlates with synovial fluid matrix metalloproteinase activity. Journal of Biomechanics. 48: 1461-8. PMID 25801424 DOI: 10.1016/J.Jbiomech.2015.02.030  0.37
2015 Lavagnino M, Wall ME, Little D, Banes AJ, Guilak F, Arnoczky SP. Tendon mechanobiology: Current knowledge and future research opportunities. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 33: 813-22. PMID 25763779 DOI: 10.1002/Jor.22871  0.666
2015 McNulty AL, Guilak F. Mechanobiology of the meniscus. Journal of Biomechanics. 48: 1469-78. PMID 25731738 DOI: 10.1016/J.Jbiomech.2015.02.008  0.426
2015 Furman BD, Kimmerling KA, Zura RD, Reilly RM, Zlowodzki MP, Huebner JL, Kraus VB, Guilak F, Olson SA. Articular ankle fracture results in increased synovitis, synovial macrophage infiltration, and synovial fluid concentrations of inflammatory cytokines and chemokines. Arthritis & Rheumatology (Hoboken, N.J.). 67: 1234-9. PMID 25707992 DOI: 10.1002/Art.39064  0.71
2015 Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, ... ... Guilak F, et al. Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. The Journal of Clinical Investigation. 125: 1147-62. PMID 25664850 DOI: 10.1172/Jci74725  0.768
2015 Kimmerling KA, Furman BD, Mangiapani DS, Moverman MA, Sinclair SM, Huebner JL, Chilkoti A, Kraus VB, Setton LA, Guilak F, Olson SA. Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis. European Cells & Materials. 29: 124-39; discussion 1. PMID 25636786 DOI: 10.22203/Ecm.V029A10  0.781
2015 Zelenski NA, Leddy HA, Sanchez-Adams J, Zhang J, Bonaldo P, Liedtke W, Guilak F. Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage. Arthritis & Rheumatology (Hoboken, N.J.). 67: 1286-94. PMID 25604429 DOI: 10.1002/Art.39034  0.813
2015 McNulty AL, Leddy HA, Liedtke W, Guilak F. TRPV4 as a therapeutic target for joint diseases. Naunyn-Schmiedeberg's Archives of Pharmacology. 388: 437-50. PMID 25519495 DOI: 10.1007/S00210-014-1078-X  0.807
2015 Diekman BO, Thakore PI, O'Connor SK, Willard VP, Brunger JM, Christoforou N, Leong KW, Gersbach CA, Guilak F. Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells. Tissue Engineering. Part A. 21: 1261-74. PMID 25517798 DOI: 10.1089/Ten.Tea.2014.0240  0.827
2015 Kabadi AM, Thakore PI, Vockley CM, Ousterout DG, Gibson TM, Guilak F, Reddy TE, Gersbach CA. Enhanced MyoD-Induced Transdifferentiation to a Myogenic Lineage by Fusion to a Potent Transactivation Domain. Acs Synthetic Biology. 4: 689-99. PMID 25494287 DOI: 10.1021/Sb500322U  0.358
2015 Brunger JM, Zutshi A, Willard VP, Gersbach CA, Guilak F. 504. Targeted Genome Engineering of Induced Pluripotent Stem Cells To Produce Auto-Regulated Inflammation Resistance for Musculoskeletal Regenerative Medicine Molecular Therapy. 23: S201-S202. DOI: 10.1016/S1525-0016(16)34113-2  0.816
2015 Cucchiarini M, McNulty AL, Mauck RL, Setton LA, Guilak F, Madry H. Advances in combining gene therapy with cell and tissue engineering-based approaches to enhance healing of the meniscus Osteoarthritis and Cartilage. DOI: 10.1016/j.joca.2016.03.018  0.554
2015 Wu C, McNeill J, Goon K, Little D, Kimmerling K, Huebner J, Kraus V, Guilak F. The effect of conditional macrophage depletion on development of injury-induced knee OA in obese transgenic MAFIA mice Osteoarthritis and Cartilage. 23: A286-A287. DOI: 10.1016/J.Joca.2015.02.522  0.797
2015 Vovos T, Furman B, Huebner J, Kimmerling K, Utturkar G, DeFrate L, Kraus V, Guilak F, Olson S. Joint incongruity and biomarkers of bone metabolism as predictors of post-traumatic arthritis in mice Osteoarthritis and Cartilage. 23: A242-A243. DOI: 10.1016/J.Joca.2015.02.449  0.713
2015 Orr SB, Chainani A, Hippensteel KJ, Kishan A, Gilchrist C, Garrigues NW, Ruch DS, Guilak F, Little D. Aligned multilayered electrospun scaffolds for rotator cuff tendon tissue engineering Acta Biomaterialia. DOI: 10.1016/j.actbio.2015.06.010  0.805
2015 Kimmerling KA, Guilak F. Anterior cruciate transection/disruption models of post-traumatic arthritis Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management. 63-74. DOI: 10.1007/978-1-4899-7606-2_6  0.713
2015 Guilak F, Diekman BO, Olson SA. Stem cell therapies for post-traumatic arthritis Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management. 343-348. DOI: 10.1007/978-1-4899-7606-2_27  0.684
2015 Furman BD, Kimmerling KA, Wu CL, Little D, Guilak F, Olson SA. Survey of animal models in post-traumatic arthritis: Choosing the right model to answer the right question Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management. 113-118. DOI: 10.1007/978-1-4899-7606-2_10  0.761
2014 Leddy HA, McNulty AL, Guilak F, Liedtke W. Unraveling the mechanism by which TRPV4 mutations cause skeletal dysplasias. Rare Diseases (Austin, Tex.). 2: e962971. PMID 26942100 DOI: 10.4161/2167549X.2014.962971  0.755
2014 Lee W, Leddy HA, Chen Y, Lee SH, Zelenski NA, McNulty AL, Wu J, Beicker KN, Coles J, Zauscher S, Grandl J, Sachs F, Guilak F, Liedtke WB. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proceedings of the National Academy of Sciences of the United States of America. 111: E5114-22. PMID 25385580 DOI: 10.1073/Pnas.1414298111  0.81
2014 Gilchrist CL, Ruch DS, Little D, Guilak F. Micro-scale and meso-scale architectural cues cooperate and compete to direct aligned tissue formation. Biomaterials. 35: 10015-24. PMID 25263687 DOI: 10.1016/J.Biomaterials.2014.08.047  0.797
2014 Sanchez-Adams J, Leddy HA, McNulty AL, O'Conor CJ, Guilak F. The mechanobiology of articular cartilage: bearing the burden of osteoarthritis. Current Rheumatology Reports. 16: 451. PMID 25182679 DOI: 10.1007/S11926-014-0451-6  0.829
2014 Wilusz RE, Sanchez-Adams J, Guilak F. The structure and function of the pericellular matrix of articular cartilage. Matrix Biology : Journal of the International Society For Matrix Biology. 39: 25-32. PMID 25172825 DOI: 10.1016/J.Matbio.2014.08.009  0.827
2014 Willard VP, Diekman BO, Sanchez-Adams J, Christoforou N, Leong KW, Guilak F. Use of cartilage derived from murine induced pluripotent stem cells for osteoarthritis drug screening. Arthritis & Rheumatology (Hoboken, N.J.). 66: 3062-72. PMID 25047145 DOI: 10.1002/Art.38780  0.811
2014 Wu CL, Jain D, McNeill JN, Little D, Anderson JA, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, Guilak F. Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury. Annals of the Rheumatic Diseases. PMID 25015373 DOI: 10.1136/Annrheumdis-2014-205601  0.784
2014 McNeill JN, Wu CL, Rabey KN, Schmitt D, Guilak F. Life-long caloric restriction does not alter the severity of age-related osteoarthritis. Age (Dordrecht, Netherlands). 36: 9669. PMID 24981112 DOI: 10.1007/S11357-014-9669-5  0.752
2014 Furman BD, Mangiapani DS, Zeitler E, Bailey KN, Horne PH, Huebner JL, Kraus VB, Guilak F, Olson SA. Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis. Arthritis Research & Therapy. 16: R134. PMID 24964765 DOI: 10.1186/Ar4591  0.322
2014 Guilak F, Butler DL, Goldstein SA, Baaijens FP. Biomechanics and mechanobiology in functional tissue engineering. Journal of Biomechanics. 47: 1933-40. PMID 24818797 DOI: 10.1016/J.Jbiomech.2014.04.019  0.393
2014 Little D, Thompson JW, Dubois LG, Ruch DS, Moseley MA, Guilak F. Proteomic differences between male and female anterior cruciate ligament and patellar tendon. Plos One. 9: e96526. PMID 24818782 DOI: 10.1371/Journal.Pone.0096526  0.628
2014 Cucchiarini M, Madry H, Guilak F, Saris DB, Stoddart MJ, Koon Wong M, Roughley PJ. A vision on the future of articular cartilage repair European Cells and Materials. 27: 12-16. PMID 24802612 DOI: 10.22203/Ecm.V027Sa03  0.37
2014 Glass KA, Link JM, Brunger JM, Moutos FT, Gersbach CA, Guilak F. Tissue-engineered cartilage with inducible and tunable immunomodulatory properties. Biomaterials. 35: 5921-31. PMID 24767790 DOI: 10.1016/J.Biomaterials.2014.03.073  0.813
2014 Sparling TL, Schmitt D, Miller CE, Guilak F, Somers TJ, Keefe FJ, Queen RM. Energy recovery in individuals with knee osteoarthritis. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 22: 747-55. PMID 24752039 DOI: 10.1016/J.Joca.2014.04.004  0.5
2014 Guilak F, Baaijens FP. Functional tissue engineering: Ten more years of progress. Journal of Biomechanics. 47: 1931-2. PMID 24746021 DOI: 10.1016/J.Jbiomech.2014.04.003  0.398
2014 Leddy HA, McNulty AL, Lee SH, Rothfusz NE, Gloss B, Kirby ML, Hutson MR, Cohn DH, Guilak F, Liedtke W. Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2525-37. PMID 24577120 DOI: 10.1096/Fj.13-245936  0.752
2014 Brunger JM, Huynh NP, Guenther CM, Perez-Pinera P, Moutos FT, Sanchez-Adams J, Gersbach CA, Guilak F. Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage. Proceedings of the National Academy of Sciences of the United States of America. 111: E798-806. PMID 24550481 DOI: 10.1073/Pnas.1321744111  0.832
2014 O'Conor CJ, Leddy HA, Benefield HC, Liedtke WB, Guilak F. TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading. Proceedings of the National Academy of Sciences of the United States of America. 111: 1316-21. PMID 24474754 DOI: 10.1073/Pnas.1319569111  0.818
2014 Chang DP, Guilak F, Jay GD, Zauscher S. Interaction of lubricin with type II collagen surfaces: adsorption, friction, and normal forces. Journal of Biomechanics. 47: 659-66. PMID 24406099 DOI: 10.1016/J.Jbiomech.2013.11.048  0.321
2014 Olson SA, Horne P, Furman B, Huebner J, Al-Rashid M, Kraus VB, Guilak F. The role of cytokines in posttraumatic arthritis. The Journal of the American Academy of Orthopaedic Surgeons. 22: 29-37. PMID 24382877 DOI: 10.5435/Jaaos-22-01-29  0.336
2014 Garrigues NW, Little D, Sanchez-Adams J, Ruch DS, Guilak F. Electrospun cartilage-derived matrix scaffolds for cartilage tissue engineering. Journal of Biomedical Materials Research. Part A. 102: 3998-4008. PMID 24375991 DOI: 10.1002/Jbm.A.35068  0.818
2014 Anderson JA, Little D, Toth AP, Moorman CT, Tucker BS, Ciccotti MG, Guilak F. Stem cell therapies for knee cartilage repair: the current status of preclinical and clinical studies. The American Journal of Sports Medicine. 42: 2253-61. PMID 24220016 DOI: 10.1177/0363546513508744  0.694
2014 Wilusz RE, Guilak F. High resistance of the mechanical properties of the chondrocyte pericellular matrix to proteoglycan digestion by chondroitinase, aggrecanase, or hyaluronidase. Journal of the Mechanical Behavior of Biomedical Materials. 38: 183-97. PMID 24156881 DOI: 10.1016/J.Jmbbm.2013.09.021  0.818
2014 Chen Y, Guilak F, Gereau IV RW, Wang F, Liedtke W. TRPV4-mediated trigeminal pain: behavior assessments and mechanisms Molecular Pain. 10: P1. DOI: 10.1186/1744-8069-10-S1-P1  0.556
2014 Guilak F. Novel approaches to joint repair Osteoarthritis and Cartilage. 22: S2. DOI: 10.1016/J.Joca.2014.02.018  0.301
2014 Lee W, Leddy H, Guilak F, Liedtke W. Characterization of Mechanotransensitivity of Articular Chondrocytes Biophysical Journal. 106: 389a-390a. DOI: 10.1016/J.Bpj.2013.11.2202  0.807
2013 Liao IC, Moutos FT, Estes BT, Zhao X, Guilak F. Composite three-dimensional woven scaffolds with interpenetrating network hydrogels to create functional synthetic articular cartilage. Advanced Functional Materials. 23: 5833-5839. PMID 24578679 DOI: 10.1002/Adfm.201300483  0.808
2013 Wilusz RE, Zauscher S, Guilak F. Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 21: 1895-903. PMID 24025318 DOI: 10.1016/J.Joca.2013.08.026  0.821
2013 Perez-Pinera P, Kocak DD, Vockley CM, Adler AF, Kabadi AM, Polstein LR, Thakore PI, Glass KA, Ousterout DG, Leong KW, Guilak F, Crawford GE, Reddy TE, Gersbach CA. RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nature Methods. 10: 973-6. PMID 23892895 DOI: 10.1038/Nmeth.2600  0.732
2013 Francisco AT, Mancino RJ, Bowles RD, Brunger JM, Tainter DM, Chen YT, Richardson WJ, Guilak F, Setton LA. Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration. Biomaterials. 34: 7381-8. PMID 23849345 DOI: 10.1016/J.Biomaterials.2013.06.038  0.777
2013 Widmyer MR, Utturkar GM, Leddy HA, Coleman JL, Spritzer CE, Moorman CT, DeFrate LE, Guilak F. High body mass index is associated with increased diurnal strains in the articular cartilage of the knee. Arthritis and Rheumatism. 65: 2615-22. PMID 23818303 DOI: 10.1002/Art.38062  0.718
2013 O'Conor CJ, Case N, Guilak F. Mechanical regulation of chondrogenesis. Stem Cell Research & Therapy. 4: 61. PMID 23809493 DOI: 10.1186/Scrt211  0.796
2013 Chainani A, Hippensteel KJ, Kishan A, Garrigues NW, Ruch DS, Guilak F, Little D. Multilayered electrospun scaffolds for tendon tissue engineering. Tissue Engineering. Part A. 19: 2594-604. PMID 23808760 DOI: 10.1089/Ten.Tea.2013.0165  0.831
2013 Chen Y, Williams SH, McNulty AL, Hong JH, Lee SH, Rothfusz NE, Parekh PK, Moore C, Gereau RW, Taylor AB, Wang F, Guilak F, Liedtke W. Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion. Pain. 154: 1295-304. PMID 23726674 DOI: 10.1016/J.Pain.2013.04.004  0.561
2013 Rowland CR, Lennon DP, Caplan AI, Guilak F. The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs. Biomaterials. 34: 5802-12. PMID 23642532 DOI: 10.1016/J.Biomaterials.2013.04.027  0.813
2013 Johnstone B, Alini M, Cucchiarini M, Dodge GR, Eglin D, Guilak F, Madry H, Mata A, Mauck RL, Semino CE, Stoddart MJ. Tissue engineering for articular cartilage repair--the state of the art. European Cells & Materials. 25: 248-67. PMID 23636950 DOI: 10.22203/Ecm.V025A18  0.423
2013 Stolberg-Stolberg JA, Furman BD, Garrigues NW, Lee J, Pisetsky DS, Stearns NA, DeFrate LE, Guilak F, Olson SA. Effects of cartilage impact with and without fracture on chondrocyte viability and the release of inflammatory markers. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 31: 1283-92. PMID 23620164 DOI: 10.1002/Jor.22348  0.771
2013 Sanchez-Adams J, Wilusz RE, Guilak F. Atomic force microscopy reveals regional variations in the micromechanical properties of the pericellular and extracellular matrices of the meniscus. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 31: 1218-25. PMID 23568545 DOI: 10.1002/Jor.22362  0.793
2013 McNulty AL, Rothfusz NE, Leddy HA, Guilak F. Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 31: 1039-45. PMID 23483596 DOI: 10.1002/Jor.22334  0.708
2013 Perez-Pinera P, Ousterout DG, Brunger JM, Farin AM, Glass KA, Guilak F, Crawford GE, Hartemink AJ, Gersbach CA. Synergistic and tunable human gene activation by combinations of synthetic transcription factors. Nature Methods. 10: 239-42. PMID 23377379 DOI: 10.1038/Nmeth.2361  0.773
2013 Lewis JS, Furman BD, Zeitler E, Huebner JL, Kraus VB, Guilak F, Olson SA. Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice Arthritis and Rheumatism. 65: 660-670. PMID 23203659 DOI: 10.1002/Art.37796  0.338
2013 Diekman BO, Guilak F. Stem cell-based therapies for osteoarthritis: challenges and opportunities. Current Opinion in Rheumatology. 25: 119-26. PMID 23190869 DOI: 10.1097/Bor.0B013E32835Aa28D  0.723
2013 O'Conor CJ, Griffin TM, Liedtke W, Guilak F. Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet. Annals of the Rheumatic Diseases. 72: 300-4. PMID 23178209 DOI: 10.1136/Annrheumdis-2012-202272  0.796
2013 Wu CL, Diekman BO, Jain D, Guilak F. Diet-induced obesity alters the differentiation potential of stem cells isolated from bone marrow, adipose tissue and infrapatellar fat pad: the effects of free fatty acids. International Journal of Obesity (2005). 37: 1079-87. PMID 23164698 DOI: 10.1038/Ijo.2012.171  0.809
2013 Coleman JL, Widmyer MR, Leddy HA, Utturkar GM, Spritzer CE, Moorman CT, Guilak F, DeFrate LE. Diurnal variations in articular cartilage thickness and strain in the human knee. Journal of Biomechanics. 46: 541-7. PMID 23102493 DOI: 10.1016/J.Jbiomech.2012.09.013  0.723
2013 Cheng NC, Estes BT, Young TH, Guilak F. Genipin-crosslinked cartilage-derived matrix as a scaffold for human adipose-derived stem cell chondrogenesis. Tissue Engineering. Part A. 19: 484-96. PMID 23088537 DOI: 10.1089/Ten.Tea.2012.0384  0.776
2013 McLeod MA, Wilusz RE, Guilak F. Depth-dependent anisotropy of the micromechanical properties of the extracellular and pericellular matrices of articular cartilage evaluated via atomic force microscopy. Journal of Biomechanics. 46: 586-92. PMID 23062866 DOI: 10.1016/J.Jbiomech.2012.09.003  0.813
2013 Diekman BO, Wu CL, Louer CR, Furman BD, Huebner JL, Kraus VB, Olson SA, Guilak F. Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic arthritis. Cell Transplantation. 22: 1395-408. PMID 22889498 DOI: 10.3727/096368912X653264  0.816
2013 Gilchrist CL, Ruch DS, Little D, Guilak F. Nano-scale and micro-scale substrate architectures direct collagen alignment in tendon neo-tissue formation Asme 2013 Summer Bioengineering Conference, Sbc 2013. 1. DOI: 10.1115/SBC2013-14474  0.768
2013 O'Conor CJ, Benefield HC, Liedtke W, Guilak F. Osmotic or chemical activation of the TRPV4 ion channel enhances the development of chondrocyte-based tissue engineered cartilage Asme 2013 Summer Bioengineering Conference, Sbc 2013. 1. DOI: 10.1115/SBC2013-14042  0.752
2013 Glass K, Brunger J, Gersbach C, Guilak F. Tunable expression of IL-1Ra in genetically modified mesenchymal stem cells for cartilage tissue engineering Osteoarthritis and Cartilage. 21: S282-S283. DOI: 10.1016/J.Joca.2013.02.591  0.812
2013 Willard V, Diekman B, Sanchez-Adams J, O'Connor S, Christoforou N, Leong K, Guilak F. Osteoarthritis in a dish: the effects of pro-inflammatory cytokines on cartilage derived from induced pluripotent stem cells Osteoarthritis and Cartilage. 21: S281-S282. DOI: 10.1016/J.Joca.2013.02.590  0.808
2013 Francisco A, Mancino R, Brunger J, Bowles R, Guilak F, Setton L. Injectable laminin-functionalized hydrogel for cell delivery to the intervertebral disc Osteoarthritis and Cartilage. 21: S278-S279. DOI: 10.1016/J.Joca.2013.02.585  0.765
2013 Wu C, Jain D, Little D, Anderson J, Huebner J, Kraus V, Rodriguiz R, Wetsel W, Guilak F. Dietary fatty acids differentially affect the development of injury-induced osteoarthritis with diet-induced obesity in mice Osteoarthritis and Cartilage. 21: S224-S225. DOI: 10.1016/J.Joca.2013.02.464  0.77
2013 Kimmerling K, Furman B, Mangiapani D, Moverman M, Sinclair S, Huebner J, Kraus V, Setton L, Guilak F, Olson S. Prolonged local delivery of IL-1Ra prevents post-traumatic arthritis in mice Osteoarthritis and Cartilage. 21: S30-S31. DOI: 10.1016/J.Joca.2013.02.082  0.625
2013 O'Conor C, Benefield H, Liedtke W, Guilak F. The transient receptor potential vanilloid 4 ion channel regulates the biosynthetic response of chondrocytes to dynamic loading Osteoarthritis and Cartilage. 21: S17-S18. DOI: 10.1016/J.Joca.2013.02.057  0.826
2013 Moffat KL, Neal RA, Freed LE, Guilak F. Engineering Functional Tissues: In Vitro Culture Parameters Principles of Tissue Engineering: Fourth Edition. 237-259. DOI: 10.1016/B978-0-12-398358-9.00013-6  0.783
2013 Liao I, Moutos FT, Estes BT, Zhao X, Guilak F. Tissue Engineering: Composite Three-Dimensional Woven Scaffolds with Interpenetrating Network Hydrogels to Create Functional Synthetic Articular Cartilage (Adv. Funct. Mater. 47/2013) Advanced Functional Materials. 23: 5825-5825. DOI: 10.1002/Adfm.201370250  0.808
2012 Rowland CR, Little D, Guilak F. Factors influencing the long-term behavior of extracellular matrix-derived scaffolds for musculoskeletal soft tissue repair. Journal of Long-Term Effects of Medical Implants. 22: 181-93. PMID 23582110 DOI: 10.1615/Jlongtermeffmedimplants.2013006120  0.831
2012 Olson SA, Furman B, Guilak F. Joint injury and post-traumatic arthritis. Hss Journal : the Musculoskeletal Journal of Hospital For Special Surgery. 8: 23-5. PMID 23372522 DOI: 10.1007/S11420-011-9247-7  0.307
2012 Diekman BO, Christoforou N, Willard VP, Sun H, Sanchez-Adams J, Leong KW, Guilak F. Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 19172-7. PMID 23115336 DOI: 10.1073/Pnas.1210422109  0.836
2012 Davis BH, Morimoto Y, Sample C, Olbrich K, Leddy HA, Guilak F, Taylor DA. Effects of myocardial infarction on the distribution and transport of nutrients and oxygen in porcine myocardium. Journal of Biomechanical Engineering. 134: 101005. PMID 23083196 DOI: 10.1115/1.4007455  0.697
2012 Ousema PH, Moutos FT, Estes BT, Caplan AI, Lennon DP, Guilak F, Weinberg JB. The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds. Biomaterials. 33: 8967-74. PMID 22999467 DOI: 10.1016/J.Biomaterials.2012.08.045  0.826
2012 Wang X, Liao S, Nelson ER, Schmalzigaug R, Spurney RF, Guilak F, Premont RT, Gesty-Palmer D. The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis. Biochemical and Biophysical Research Communications. 425: 407-12. PMID 22846567 DOI: 10.1016/J.Bbrc.2012.07.111  0.326
2012 Wilusz RE, DeFrate LE, Guilak F. Immunofluorescence-guided atomic force microscopy to measure the micromechanical properties of the pericellular matrix of porcine articular cartilage. Journal of the Royal Society, Interface / the Royal Society. 9: 2997-3007. PMID 22675162 DOI: 10.1098/Rsif.2012.0314  0.81
2012 Wilusz RE, Defrate LE, Guilak F. A biomechanical role for perlecan in the pericellular matrix of articular cartilage. Matrix Biology : Journal of the International Society For Matrix Biology. 31: 320-7. PMID 22659389 DOI: 10.1016/J.Matbio.2012.05.002  0.815
2012 Martins RP, Finan JD, Guilak F, Lee DA. Mechanical regulation of nuclear structure and function. Annual Review of Biomedical Engineering. 14: 431-55. PMID 22655599 DOI: 10.1146/Annurev-Bioeng-071910-124638  0.704
2012 Halloran JP, Sibole S, van Donkelaar CC, van Turnhout MC, Oomens CW, Weiss JA, Guilak F, Erdemir A. Multiscale mechanics of articular cartilage: potentials and challenges of coupling musculoskeletal, joint, and microscale computational models. Annals of Biomedical Engineering. 40: 2456-74. PMID 22648577 DOI: 10.1007/S10439-012-0598-0  0.373
2012 Louer CR, Furman BD, Huebner JL, Kraus VB, Olson SA, Guilak F. Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice. Arthritis and Rheumatism. 64: 3220-30. PMID 22576842 DOI: 10.1002/Art.34533  0.331
2012 Bourque CW, Guilak F, Liedtke W. A TRP that makes us feel hyper. The Journal of Physiology. 590: 1779-80. PMID 22532645 DOI: 10.1113/Jphysiol.2012.229187  0.535
2012 Somers TJ, Blumenthal JA, Guilak F, Kraus VB, Schmitt DO, Babyak MA, Craighead LW, Caldwell DS, Rice JR, McKee DC, Shelby RA, Campbell LC, Pells JJ, Sims EL, Queen R, et al. Pain coping skills training and lifestyle behavioral weight management in patients with knee osteoarthritis: a randomized controlled study. Pain. 153: 1199-209. PMID 22503223 DOI: 10.1016/J.Pain.2012.02.023  0.486
2012 Christensen SE, Coles JM, Zelenski NA, Furman BD, Leddy HA, Zauscher S, Bonaldo P, Guilak F. Altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen VI null mice. Plos One. 7: e33397. PMID 22448243 DOI: 10.1371/Journal.Pone.0033397  0.791
2012 Gimble JM, Bunnell BA, Guilak F. Human adipose-derived cells: an update on the transition to clinical translation. Regenerative Medicine. 7: 225-35. PMID 22397611 DOI: 10.2217/Rme.11.119  0.389
2012 Krishnamurthy VK, Opoka AM, Kern CB, Guilak F, Narmoneva DA, Hinton RB. Maladaptive matrix remodeling and regional biomechanical dysfunction in a mouse model of aortic valve disease. Matrix Biology : Journal of the International Society For Matrix Biology. 31: 197-205. PMID 22265892 DOI: 10.1016/J.Matbio.2012.01.001  0.318
2012 Griffin TM, Huebner JL, Kraus VB, Yan Z, Guilak F. Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise. Arthritis and Rheumatism. 64: 443-53. PMID 21953366 DOI: 10.1002/Art.33332  0.585
2012 Seifer DR, Furman BD, Guilak F, Olson SA, Brooks SC, Kraus VB. Corrigendum to "Novel synovial fluid recovery method allows for quantification of a marker of arthritis in mice" [Osteoarthritis and Cartilage 2008;16(12): 1532-1538 Osteoarthritis and Cartilage. 20: 68. DOI: 10.1016/J.Joca.2011.11.001  0.311
2011 Guilak F. Biomechanical factors in osteoarthritis. Best Practice & Research. Clinical Rheumatology. 25: 815-23. PMID 22265263 DOI: 10.1016/J.Berh.2011.11.013  0.401
2011 Riera KM, Rothfusz NE, Wilusz RE, Weinberg JB, Guilak F, McNulty AL. Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration. Arthritis Research & Therapy. 13: R187. PMID 22087734 DOI: 10.1186/Ar3515  0.818
2011 Lozoya OA, Wauthier E, Turner RA, Barbier C, Prestwich GD, Guilak F, Superfine R, Lubkin SR, Reid LM. Regulation of hepatic stem/progenitor phenotype by microenvironment stiffness in hydrogel models of the human liver stem cell niche. Biomaterials. 32: 7389-402. PMID 21788068 DOI: 10.1016/J.Biomaterials.2011.06.042  0.582
2011 McNulty AL, Miller MR, O'Connor SK, Guilak F. The effects of adipokines on cartilage and meniscus catabolism. Connective Tissue Research. 52: 523-33. PMID 21787135 DOI: 10.3109/03008207.2011.597902  0.375
2011 Lewis JS, Hembree WC, Furman BD, Tippets L, Cattel D, Huebner JL, Little D, DeFrate LE, Kraus VB, Guilak F, Olson SA. Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 19: 864-73. PMID 21619936 DOI: 10.1016/J.Joca.2011.04.011  0.626
2011 Anderson DD, Chubinskaya S, Guilak F, Martin JA, Oegema TR, Olson SA, Buckwalter JA. Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 29: 802-9. PMID 21520254 DOI: 10.1002/Jor.21359  0.321
2011 Gimble JM, Bunnell BA, Chiu ES, Guilak F. Taking stem cells beyond discovery: a milestone in the reporting of regulatory requirements for cell therapy. Stem Cells and Development. 20: 1295-6. PMID 21510815 DOI: 10.1089/Scd.2011.0198  0.345
2011 Finan JD, Leddy HA, Guilak F. Osmotic stress alters chromatin condensation and nucleocytoplasmic transport. Biochemical and Biophysical Research Communications. 408: 230-5. PMID 21463604 DOI: 10.1016/J.Bbrc.2011.03.131  0.777
2011 Gimble JM, Bunnell BA, Chiu ES, Guilak F. Concise review: Adipose-derived stromal vascular fraction cells and stem cells: let's not get lost in translation. Stem Cells (Dayton, Ohio). 29: 749-54. PMID 21433220 DOI: 10.1002/Stem.629  0.379
2011 Backus JD, Furman BD, Swimmer T, Kent CL, McNulty AL, Defrate LE, Guilak F, Olson SA. Cartilage viability and catabolism in the intact porcine knee following transarticular impact loading with and without articular fracture. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 29: 501-10. PMID 21337389 DOI: 10.1002/Jor.21270  0.303
2011 Gimble JM, Grayson W, Guilak F, Lopez MJ, Vunjak-Novakovic G. Adipose tissue as a stem cell source for musculoskeletal regeneration. Frontiers in Bioscience (Scholar Edition). 3: 69-81. PMID 21196358 DOI: 10.2741/S133  0.422
2011 Cheng NC, Estes BT, Young TH, Guilak F. Engineered cartilage using primary chondrocytes cultured in a porous cartilage-derived matrix. Regenerative Medicine. 6: 81-93. PMID 21175289 DOI: 10.2217/Rme.10.87  0.759
2011 Estes BT, Guilak F. Three-dimensional culture systems to induce chondrogenesis of adipose-derived stem cells. Methods in Molecular Biology (Clifton, N.J.). 702: 201-17. PMID 21082404 DOI: 10.1007/978-1-61737-960-4_15  0.758
2011 Krishnamurthy VK, Guilak F, Narmoneva DA, Hinton RB. Regional structure-function relationships in mouse aortic valve tissue. Journal of Biomechanics. 44: 77-83. PMID 20863504 DOI: 10.1016/J.Jbiomech.2010.08.026  0.325
2011 Zur G, Linder-Ganz E, Elsner JJ, Shani J, Brenner O, Agar G, Hershman EB, Arnoczky SP, Guilak F, Shterling A. Chondroprotective effects of a polycarbonate-urethane meniscal implant: histopathological results in a sheep model. Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the Esska. 19: 255-63. PMID 20635076 DOI: 10.1007/S00167-010-1210-5  0.314
2011 Cao L, Guilak F, Setton LA. Three-dimensional finite element modeling of pericellular matrix and cell mechanics in the nucleus pulposus of the intervertebral disk based on in situ morphology. Biomechanics and Modeling in Mechanobiology. 10: 1-10. PMID 20376522 DOI: 10.1007/S10237-010-0214-X  0.592
2011 Diekman B, Wu C, Louer C, Furman B, Huebner J, Kraus V, Olson S, Guilak F. 1-17 INTRA-ARTICULAR INJECTION OF PURIFIED MESENCHYMAL STEM CELLS FROM C57BL/6 OR MRL/MPJ “SUPERHEALER” MICE PREVENTS POSTTRAUMATIC ARTHRITIS Osteoarthritis and Cartilage. 19: S5. DOI: 10.1016/S1063-4584(11)60023-X  0.797
2010 Guilak F. Homing in on a biological joint replacement. Stem Cell Research & Therapy. 1: 40. PMID 21156083 DOI: 10.1186/Scrt40  0.426
2010 Garrigues NW, Little D, O'Conor CJ, Guilak F. Use of an insulating mask for controlling anisotropy in multilayer electrospun scaffolds for tissue engineering. Journal of Materials Chemistry. 20: 8962-8968. PMID 21072247 DOI: 10.1039/C0Jm01880E  0.794
2010 Elsner JJ, Portnoy S, Guilak F, Shterling A, Linder-Ganz E. MRI-based characterization of bone anatomy in the human knee for size matching of a medial meniscal implant. Journal of Biomechanical Engineering. 132: 101008. PMID 20887018 DOI: 10.1115/1.4002490  0.301
2010 Moutos FT, Estes BT, Guilak F. Multifunctional hybrid three-dimensionally woven scaffolds for cartilage tissue engineering. Macromolecular Bioscience. 10: 1355-64. PMID 20857388 DOI: 10.1002/Mabi.201000124  0.828
2010 Abrahamsson CK, Yang F, Park H, Brunger JM, Valonen PK, Langer R, Welter JF, Caplan AI, Guilak F, Freed LE. Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds. Tissue Engineering. Part A. 16: 3709-18. PMID 20673022 DOI: 10.1089/Ten.Tea.2010.0190  0.756
2010 Guilak F, Estes BT, Diekman BO, Moutos FT, Gimble JM. 2010 Nicolas Andry Award: Multipotent adult stem cells from adipose tissue for musculoskeletal tissue engineering. Clinical Orthopaedics and Related Research. 468: 2530-40. PMID 20625952 DOI: 10.1007/S11999-010-1410-9  0.827
2010 Griffin TM, Fermor B, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, Cao L, Setton LA, Guilak F. Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Research & Therapy. 12: R130. PMID 20604941 DOI: 10.1186/Ar3068  0.711
2010 Estes BT, Diekman BO, Gimble JM, Guilak F. Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype. Nature Protocols. 5: 1294-311. PMID 20595958 DOI: 10.1038/Nprot.2010.81  0.821
2010 Gimble JM, Guilak F, Bunnell BA. Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells. Stem Cell Research & Therapy. 1: 19. PMID 20587076 DOI: 10.1186/Scrt19  0.381
2010 Clark AL, Votta BJ, Kumar S, Liedtke W, Guilak F. Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. Arthritis and Rheumatism. 62: 2973-83. PMID 20583100 DOI: 10.1002/Art.27624  0.604
2010 Darling EM, Wilusz RE, Bolognesi MP, Zauscher S, Guilak F. Spatial mapping of the biomechanical properties of the pericellular matrix of articular cartilage measured in situ via atomic force microscopy. Biophysical Journal. 98: 2848-56. PMID 20550897 DOI: 10.1016/J.Bpj.2010.03.037  0.812
2010 Kim E, Guilak F, Haider MA. An axisymmetric boundary element model for determination of articular cartilage pericellular matrix properties in situ via inverse analysis of chondron deformation. Journal of Biomechanical Engineering. 132: 031011. PMID 20459199 DOI: 10.1115/1.4000938  0.398
2010 Little D, Guilak F, Ruch DS. Ligament-derived matrix stimulates a ligamentous phenotype in human adipose-derived stem cells. Tissue Engineering. Part A. 16: 2307-19. PMID 20406104 DOI: 10.1089/Ten.Tea.2009.0720  0.708
2010 Guilak F, Leddy HA, Liedtke W. Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system? Annals of the New York Academy of Sciences. 1192: 404-9. PMID 20392266 DOI: 10.1111/J.1749-6632.2010.05389.X  0.779
2010 Costello KE, Guilak F, Setton LA, Griffin TM. Locomotor activity and gait in aged mice deficient for type IX collagen. Journal of Applied Physiology (Bethesda, Md. : 1985). 109: 211-8. PMID 20360435 DOI: 10.1152/Japplphysiol.00056.2010  0.684
2010 Chuckpaiwong B, Charles HC, Kraus VB, Guilak F, Nunley JA. Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 28: 1149-54. PMID 20225314 DOI: 10.1002/Jor.21125  0.311
2010 Shaked NT, Finan JD, Guilak F, Wax A. Quantitative phase microscopy of articular chondrocyte dynamics by wide-field digital interferometry. Journal of Biomedical Optics. 15: 010505. PMID 20210420 DOI: 10.1117/1.3290242  0.675
2010 McNulty AL, Estes BT, Wilusz RE, Weinberg JB, Guilak F. Dynamic loading enhances integrative meniscal repair in the presence of interleukin-1. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 18: 830-8. PMID 20202487 DOI: 10.1016/J.Joca.2010.02.009  0.8
2010 Coles JM, Zhang L, Blum JJ, Warman ML, Jay GD, Guilak F, Zauscher S. Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4. Arthritis and Rheumatism. 62: 1666-74. PMID 20191580 DOI: 10.1002/Art.27436  0.336
2010 Valonen PK, Moutos FT, Kusanagi A, Moretti MG, Diekman BO, Welter JF, Caplan AI, Guilak F, Freed LE. In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(epsilon-caprolactone) scaffolds. Biomaterials. 31: 2193-200. PMID 20034665 DOI: 10.1016/J.Biomaterials.2009.11.092  0.824
2010 Finan JD, Guilak F. The effects of osmotic stress on the structure and function of the cell nucleus. Journal of Cellular Biochemistry. 109: 460-7. PMID 20024954 DOI: 10.1002/Jcb.22437  0.702
2010 Moutos FT, Guilak F. Functional properties of cell-seeded three-dimensionally woven poly(epsilon-caprolactone) scaffolds for cartilage tissue engineering. Tissue Engineering. Part A. 16: 1291-301. PMID 19903085 DOI: 10.1089/Ten.Tea.2009.0480  0.772
2010 Yim EK, Darling EM, Kulangara K, Guilak F, Leong KW. Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells. Biomaterials. 31: 1299-306. PMID 19879643 DOI: 10.1016/J.Biomaterials.2009.10.037  0.682
2010 Diekman BO, Estes BT, Guilak F. The effects of BMP6 overexpression on adipose stem cell chondrogenesis: Interactions with dexamethasone and exogenous growth factors. Journal of Biomedical Materials Research. Part A. 93: 994-1003. PMID 19722282 DOI: 10.1002/Jbm.A.32589  0.794
2010 Diekman BO, Rowland CR, Lennon DP, Caplan AI, Guilak F. Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix. Tissue Engineering. Part A. 16: 523-33. PMID 19715387 DOI: 10.1089/Ten.Tea.2009.0398  0.822
2010 Coles JM, Blum JJ, Jay GD, Darling EM, Guilak F, Zauscher S. Corrigendum to In situ friction measurement on murine cartilage by atomic force microscopy [J. Biomech. 41, 3, (2008) 541-548] Journal of Biomechanics. 43: 2866. DOI: 10.1016/J.Jbiomech.2010.09.020  0.62
2010 Moutos FT, Estes BT, Guilak F. Macromol. Biosci. 11/2010 Macromolecular Bioscience. 10: n/a-n/a. DOI: 10.1002/Mabi.201090026  0.777
2009 Freed LE, Engelmayr GC, Borenstein JT, Moutos FT, Guilak F. Advanced material strategies for tissue engineering scaffolds. Advanced Materials (Deerfield Beach, Fla.). 21: 3410-8. PMID 20882506 DOI: 10.1002/Adma.200900303  0.743
2009 Darling EM, Pritchett PE, Evans BA, Superfine R, Zauscher S, Guilak F. Mechanical properties and gene expression of chondrocytes on micropatterned substrates following dedifferentiation in monolayer. Cellular and Molecular Bioengineering. 2: 395-404. PMID 20625462 DOI: 10.1007/S12195-009-0077-3  0.695
2009 Sims EL, Carland JM, Keefe FJ, Kraus VB, Guilak F, Schmitt D. Sex differences in biomechanics associated with knee osteoarthritis. Journal of Women & Aging. 21: 159-70. PMID 20183142 DOI: 10.1080/08952840903054856  0.514
2009 Sims EL, Keefe FJ, Kraus VB, Guilak F, Queen RM, Schmitt D. Racial differences in gait mechanics associated with knee osteoarthritis. Aging Clinical and Experimental Research. 21: 463-9. PMID 20154517 DOI: 10.1007/Bf03327442  0.51
2009 Cao L, Guilak F, Setton LA. Pericellular Matrix Mechanics in the Anulus Fibrosus Predicted by a Three-Dimensional Finite Element Model and In Situ Morphology. Cellular and Molecular Bioengineering. 2: 306-319. PMID 19946619 DOI: 10.1007/S12195-009-0081-7  0.603
2009 Nebel MB, Sims EL, Keefe FJ, Kraus VB, Guilak F, Caldwell DS, Pells JJ, Queen R, Schmitt D. The relationship of self-reported pain and functional impairment to gait mechanics in overweight and obese persons with knee osteoarthritis. Archives of Physical Medicine and Rehabilitation. 90: 1874-9. PMID 19887211 DOI: 10.1016/J.Apmr.2009.07.010  0.512
2009 Phan MN, Leddy HA, Votta BJ, Kumar S, Levy DS, Lipshutz DB, Lee SH, Liedtke W, Guilak F. Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis and Rheumatism. 60: 3028-37. PMID 19790068 DOI: 10.1002/Art.24799  0.771
2009 Griffin TM, Huebner JL, Kraus VB, Guilak F. Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. Arthritis and Rheumatism. 60: 2935-44. PMID 19790050 DOI: 10.1002/Art.24854  0.602
2009 Guilak F, Cohen DM, Estes BT, Gimble JM, Liedtke W, Chen CS. Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell. 5: 17-26. PMID 19570510 DOI: 10.1016/J.Stem.2009.06.016  0.797
2009 Discher D, Dong C, Fredberg JJ, Guilak F, Ingber D, Janmey P, Kamm RD, Schmid-Schönbein GW, Weinbaum S. Biomechanics: cell research and applications for the next decade. Annals of Biomedical Engineering. 37: 847-59. PMID 19259817 DOI: 10.1007/S10439-009-9661-X  0.304
2009 Alexopoulos LG, Youn I, Bonaldo P, Guilak F. Developmental and osteoarthritic changes in Col6a1-knockout mice: biomechanics of type VI collagen in the cartilage pericellular matrix. Arthritis and Rheumatism. 60: 771-9. PMID 19248115 DOI: 10.1002/Art.24293  0.782
2009 Finan JD, Chalut KJ, Wax A, Guilak F. Nonlinear osmotic properties of the cell nucleus. Annals of Biomedical Engineering. 37: 477-91. PMID 19107599 DOI: 10.1007/S10439-008-9618-5  0.689
2009 McNulty AL, Weinberg JB, Guilak F. Inhibition of matrix metalloproteinases enhances in vitro repair of the meniscus. Clinical Orthopaedics and Related Research. 467: 1557-67. PMID 18975039 DOI: 10.1007/S11999-008-0596-6  0.337
2009 Cheng NC, Estes BT, Awad HA, Guilak F. Chondrogenic differentiation of adipose-derived adult stem cells by a porous scaffold derived from native articular cartilage extracellular matrix. Tissue Engineering. Part A. 15: 231-41. PMID 18950290 DOI: 10.1089/Ten.Tea.2008.0253  0.82
2009 Wilusz RE, Darling EM, Bolognesi MP, Zauscher S, Guilak F. The inhomogeneous mechanical properties of the pericellular matrix of articular cartilage measured in situ by atomic force microscopy Proceedings of the Asme Summer Bioengineering Conference 2009, Sbc2009. 1065-1066. DOI: 10.1115/SBC2009-206403  0.794
2009 Finan JD, Guilak F. Osmotic stress affects nuclear morphology and genome architecture Proceedings of the Asme Summer Bioengineering Conference 2009, Sbc2009. 1001-1002. DOI: 10.1115/SBC2009-205759  0.619
2009 Darling E, Pritchett P, Evans B, Superfine R, Zauscher S, Guilak F. 209 THE ASSOCIATION OF CHONDROCYTE MECHANICAL PROPERTIES AND PHENOTYPIC EXPRESSION DURING CELLULAR EXPANSION ON MICROPATTERNED SUBSTRATES Osteoarthritis and Cartilage. 17: S119. DOI: 10.1016/S1063-4584(09)60231-4  0.648
2009 Freed LE, Engelmayr GC, Borenstein JT, Moutos FT, Guilak F. Tissue Engineering: Advanced Material Strategies for Tissue Engineering Scaffolds (Adv. Mater. 32-33/2009) Advanced Materials. 21: NA-NA. DOI: 10.1002/Adma.200990125  0.726
2008 Gimble JM, Guilak F, Nuttall ME, Sathishkumar S, Vidal M, Bunnell BA. In vitro Differentiation Potential of Mesenchymal Stem Cells. Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie. 35: 228-238. PMID 21547120 DOI: 10.1159/000124281  0.419
2008 Kim E, Guilak F, Haider MA. The dynamic mechanical environment of the chondrocyte: a biphasic finite element model of cell-matrix interactions under cyclic compressive loading. Journal of Biomechanical Engineering. 130: 061009. PMID 19045538 DOI: 10.1115/1.2978991  0.381
2008 Leddy HA, Christensen SE, Guilak F. Microscale diffusion properties of the cartilage pericellular matrix measured using 3D scanning microphotolysis. Journal of Biomechanical Engineering. 130: 061002. PMID 19045531 DOI: 10.1115/1.2979876  0.785
2008 Moutos FT, Guilak F. Composite scaffolds for cartilage tissue engineering. Biorheology. 45: 501-12. PMID 18836249 DOI: 10.3233/Bir-2008-0491  0.756
2008 McNulty AL, Guilak F. Integrative repair of the meniscus: lessons from in vitro studies. Biorheology. 45: 487-500. PMID 18836248 DOI: 10.3233/Bir-2008-0489  0.388
2008 Griffin TM, Guilak F. Why is obesity associated with osteoarthritis? Insights from mouse models of obesity. Biorheology. 45: 387-98. PMID 18836239 DOI: 10.3233/Bir-2008-0485  0.578
2008 Leddy HA, Guilak F. Site-specific effects of compression on macromolecular diffusion in articular cartilage. Biophysical Journal. 95: 4890-5. PMID 18689460 DOI: 10.1529/Biophysj.108.137752  0.725
2008 Darling EM, Guilak F. A neural network model for cell classification based on single-cell biomechanical properties. Tissue Engineering. Part A. 14: 1507-15. PMID 18620486 DOI: 10.1089/Ten.Tea.2008.0180  0.682
2008 Bunnell BA, Estes BT, Guilak F, Gimble JM. Differentiation of adipose stem cells. Methods in Molecular Biology (Clifton, N.J.). 456: 155-71. PMID 18516560 DOI: 10.1007/978-1-59745-245-8_12  0.734
2008 Pritchard S, Votta BJ, Kumar S, Guilak F. Interleukin-1 inhibits osmotically induced calcium signaling and volume regulation in articular chondrocytes Osteoarthritis and Cartilage. 16: 1466-1473. PMID 18495501 DOI: 10.1016/J.Joca.2008.04.003  0.726
2008 Upton ML, Gilchrist CL, Guilak F, Setton LA. Transfer of macroscale tissue strain to microscale cell regions in the deformed meniscus. Biophysical Journal. 95: 2116-24. PMID 18487290 DOI: 10.1529/Biophysj.107.126938  0.797
2008 Chalut KJ, Chen S, Finan JD, Giacomelli MG, Guilak F, Leong KW, Wax A. Label-free, high-throughput measurements of dynamic changes in cell nuclei using angle-resolved low coherence interferometry. Biophysical Journal. 94: 4948-56. PMID 18326642 DOI: 10.1529/Biophysj.107.124107  0.69
2008 Coles JM, Blum JJ, Jay GD, Darling EM, Guilak F, Zauscher S. In situ friction measurement on murine cartilage by atomic force microscopy. Journal of Biomechanics. 41: 541-8. PMID 18054362 DOI: 10.1016/J.Jbiomech.2007.10.013  0.664
2008 Wilusz RE, Weinberg JB, Guilak F, McNulty AL. Inhibition of integrative repair of the meniscus following acute exposure to interleukin-1 in vitro. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 26: 504-12. PMID 18050309 DOI: 10.1002/Jor.20538  0.8
2008 Estes BT, Diekman BO, Guilak F. Monolayer cell expansion conditions affect the chondrogenic potential of adipose-derived stem cells. Biotechnology and Bioengineering. 99: 986-95. PMID 17929321 DOI: 10.1002/Bit.21662  0.814
2008 Darling EM, Topel M, Zauscher S, Vail TP, Guilak F. Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes. Journal of Biomechanics. 41: 454-64. PMID 17825308 DOI: 10.1016/J.Jbiomech.2007.06.019  0.716
2008 Leddy H, Phan M, Votta B, Kumar S, Lee S, Liedtke W, Guilak F. A6 FUNCTIONAL CHARACTERIZATION OF TRPV4 AS AN OSMOTICALLY SENSITIVE ION CHANNEL IN ARTICULAR CHONDROCYTES Osteoarthritis and Cartilage. 16: S15-S16. DOI: 10.1016/S1063-4584(08)60052-7  0.744
2007 Haider MA, Guilak F. Application of a Three-Dimensional Poroelastic BEM to Modeling the Biphasic Mechanics of Cell-Matrix Interactions in Articular Cartilage (REVISION). Computer Methods in Applied Mechanics and Engineering. 196: 2999-3010. PMID 19851478 DOI: 10.1016/J.Cma.2006.08.020  0.364
2007 Hembree WC, Ward BD, Furman BD, Zura RD, Nichols LA, Guilak F, Olson SA. Viability and apoptosis of human chondrocytes in osteochondral fragments following joint trauma. The Journal of Bone and Joint Surgery. British Volume. 89: 1388-95. PMID 17957084 DOI: 10.1302/0301-620X.89B10.18907  0.328
2007 McNulty AL, Moutos FT, Weinberg JB, Guilak F. Enhanced integrative repair of the porcine meniscus in vitro by inhibition of interleukin-1 or tumor necrosis factor alpha. Arthritis and Rheumatism. 56: 3033-42. PMID 17729298 DOI: 10.1002/Art.22839  0.717
2007 Cao L, Guilak F, Setton LA. Three-dimensional morphology of the pericellular matrix of intervertebral disc cells in the rat. Journal of Anatomy. 211: 444-52. PMID 17672847 DOI: 10.1111/J.1469-7580.2007.00784.X  0.59
2007 Weinberg JB, Fermor B, Guilak F. Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair. Sub-Cellular Biochemistry. 42: 31-62. PMID 17612045 DOI: 10.1007/1-4020-5688-5_2  0.377
2007 Hennerbichler A, Fermor B, Hennerbichler D, Weinberg JB, Guilak F. Regional differences in prostaglandin E2 and nitric oxide production in the knee meniscus in response to dynamic compression. Biochemical and Biophysical Research Communications. 358: 1047-53. PMID 17517372 DOI: 10.1016/J.Bbrc.2007.05.026  0.341
2007 Hennerbichler A, Moutos FT, Hennerbichler D, Weinberg JB, Guilak F. Interleukin-1 and tumor necrosis factor alpha inhibit repair of the porcine meniscus in vitro. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 15: 1053-60. PMID 17448702 DOI: 10.1016/J.Joca.2007.03.003  0.727
2007 Davis BH, Schroeder T, Yarmolenko PS, Guilak F, Dewhirst MW, Taylor DA. An in vitro system to evaluate the effects of ischemia on survival of cells used for cell therapy. Annals of Biomedical Engineering. 35: 1414-24. PMID 17417737 DOI: 10.1007/S10439-007-9301-2  0.327
2007 Choi JB, Youn I, Cao L, Leddy HA, Gilchrist CL, Setton LA, Guilak F. Zonal changes in the three-dimensional morphology of the chondron under compression: the relationship among cellular, pericellular, and extracellular deformation in articular cartilage. Journal of Biomechanics. 40: 2596-603. PMID 17397851 DOI: 10.1016/J.Jbiomech.2007.01.009  0.806
2007 Hennerbichler A, Moutos FT, Hennerbichler D, Weinberg JB, Guilak F. Repair response of the inner and outer regions of the porcine meniscus in vitro. The American Journal of Sports Medicine. 35: 754-62. PMID 17261570 DOI: 10.1177/0363546506296416  0.74
2007 Moutos FT, Freed LE, Guilak F. A biomimetic three-dimensional woven composite scaffold for functional tissue engineering of cartilage. Nature Materials. 6: 162-7. PMID 17237789 DOI: 10.1038/Nmat1822  0.765
2007 Darling EM, Zauscher S, Block JA, Guilak F. A thin-layer model for viscoelastic, stress-relaxation testing of cells using atomic force microscopy: do cell properties reflect metastatic potential? Biophysical Journal. 92: 1784-91. PMID 17158567 DOI: 10.1529/Biophysj.106.083097  0.668
2007 Gilchrist CL, Witvoet-Braam SW, Guilak F, Setton LA. Measurement of intracellular strain on deformable substrates with texture correlation. Journal of Biomechanics. 40: 786-94. PMID 16698026 DOI: 10.1016/J.Jbiomech.2006.03.013  0.793
2007 McNulty AL, Moutos FT, Weinberg JB, Guilak F. Strategies to Enhance Repair of the Meniscus Medicine & Science in Sports & Exercise. 39: 44. DOI: 10.1249/01.Mss.0000272380.27893.C0  0.698
2007 Estes BT, Moutos FT, Guilak F. Adipose-Derived Adult Stem Cells for Cartilage Repair Medicine & Science in Sports & Exercise. 39: 44. DOI: 10.1249/01.Mss.0000272379.27893.A6  0.806
2007 Griffin T, Fermor B, Guilak F. 170 ADIPOKINES AND OSTEOARTHRITIS: SYNERGISTIC EFFECTS OF LEPTIN, FATTY ACIDS AND INTERLEUKIN-1 ON PROTEOGLYCAN BREAKDOWN Osteoarthritis and Cartilage. 15: C102. DOI: 10.1016/S1063-4584(07)61803-2  0.553
2007 Sims E, Keefe F, Kraus V, Guilak F, Schmitt D. 47 RACIAL DIFFERENCES IN GAIT MECHANICS, PAIN, AND SELF-REPORTED DISABILITY ASSOCIATED WITH OSTEOARTHRITIS OF THE KNEE Osteoarthritis and Cartilage. 15: C39-C40. DOI: 10.1016/S1063-4584(07)61683-5  0.505
2007 Griffin T, Huebner J, Kraus V, Guilak F. 33 EXTREME OBESITY DUE TO IMPAIRED LEPTIN SIGNALING DOES NOT CAUSE OSTEOARTHRITIS IN MICE Osteoarthritis and Cartilage. 15: C32-C33. DOI: 10.1016/S1063-4584(07)61669-0  0.556
2007 Setton L, Nettles D, Lim D, Guilak F, Chilkoti A. 4.1 Genetically engineered elastin-like polypeptides for cartilage tissue regeneration Osteoarthritis and Cartilage. 15: B2-B5. DOI: 10.1016/S1063-4584(07)61225-4  0.594
2006 Freed LE, Guilak F, Guo XE, Gray ML, Tranquillo R, Holmes JW, Radisic M, Sefton MV, Kaplan D, Vunjak-Novakovic G. Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling. Tissue Engineering. 12: 3285-305. PMID 17518670 DOI: 10.1089/Ten.2006.12.3285  0.392
2006 Furman BD, Olson SA, Guilak F. The development of posttraumatic arthritis after articular fracture. Journal of Orthopaedic Trauma. 20: 719-25. PMID 17106385 DOI: 10.1097/01.Bot.0000211160.05864.14  0.349
2006 Cao L, Youn I, Guilak F, Setton LA. Compressive properties of mouse articular cartilage determined in a novel micro-indentation test method and biphasic finite element model. Journal of Biomechanical Engineering. 128: 766-71. PMID 16995764 DOI: 10.1115/1.2246237  0.745
2006 Upton ML, Hennerbichler A, Fermor B, Guilak F, Weinberg JB, Setton LA. Biaxial strain effects on cells from the inner and outer regions of the meniscus. Connective Tissue Research. 47: 207-14. PMID 16987752 DOI: 10.1080/03008200600846663  0.608
2006 Estes BT, Wu AW, Storms RW, Guilak F. Extended passaging, but not aldehyde dehydrogenase activity, increases the chondrogenic potential of human adipose-derived adult stem cells. Journal of Cellular Physiology. 209: 987-95. PMID 16972251 DOI: 10.1002/Jcp.20808  0.734
2006 Hu K, Xu L, Cao L, Flahiff CM, Brussiau J, Ho K, Setton LA, Youn I, Guilak F, Olsen BR, Li Y. Pathogenesis of osteoarthritis-like changes in the joints of mice deficient in type IX collagen Arthritis and Rheumatism. 54: 2891-2900. PMID 16947423 DOI: 10.1002/Art.22040  0.739
2006 Guilak F, Alexopoulos LG, Upton ML, Youn I, Choi JB, Cao L, Setton LA, Haider MA. The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage. Annals of the New York Academy of Sciences. 1068: 498-512. PMID 16831947 DOI: 10.1196/Annals.1346.011  0.821
2006 Pritchard S, Guilak F. Effects of interleukin-1 on calcium signaling and the increase of filamentous actin in isolated and in situ articular chondrocytes. Arthritis and Rheumatism. 54: 2164-74. PMID 16802354 DOI: 10.1002/Art.21941  0.707
2006 Qi J, Fox AM, Alexopoulos LG, Chi L, Bynum D, Guilak F, Banes AJ. IL-1beta decreases the elastic modulus of human tenocytes. Journal of Applied Physiology (Bethesda, Md. : 1985). 101: 189-95. PMID 16627678 DOI: 10.1152/Japplphysiol.01128.2005  0.598
2006 Youn I, Choi JB, Cao L, Setton LA, Guilak F. Zonal variations in the three-dimensional morphology of the chondron measured in situ using confocal microscopy Osteoarthritis and Cartilage. 14: 889-897. PMID 16626979 DOI: 10.1016/J.Joca.2006.02.017  0.755
2006 Leddy HA, Haider MA, Guilak F. Diffusional anisotropy in collagenous tissues: fluorescence imaging of continuous point photobleaching. Biophysical Journal. 91: 311-6. PMID 16603503 DOI: 10.1529/Biophysj.105.075283  0.721
2006 Estes BT, Wu AW, Guilak F. Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6. Arthritis and Rheumatism. 54: 1222-32. PMID 16572454 DOI: 10.1002/Art.21779  0.757
2006 Haider MA, Schugart RC, Setton LA, Guilak F. A mechano-chemical model for the passive swelling response of an isolated chondron under osmotic loading. Biomechanics and Modeling in Mechanobiology. 5: 160-71. PMID 16520959 DOI: 10.1007/S10237-006-0026-1  0.585
2006 Upton ML, Guilak F, Laursen TA, Setton LA. Finite element modeling predictions of region-specific cell-matrix mechanics in the meniscus. Biomechanics and Modeling in Mechanobiology. 5: 140-9. PMID 16520958 DOI: 10.1007/S10237-006-0031-4  0.613
2006 Darling EM, Zauscher S, Guilak F. Viscoelastic properties of zonal articular chondrocytes measured by atomic force microscopy. Osteoarthritis and Cartilage. 14: 571-9. PMID 16478668 DOI: 10.1016/J.Joca.2005.12.003  0.665
2006 Fetter NL, Leddy HA, Guilak F, Nunley JA. Composition and transport properties of human ankle and knee cartilage. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 24: 211-9. PMID 16435350 DOI: 10.1002/Jor.20029  0.736
2006 Trickey WR, Baaijens FP, Laursen TA, Alexopoulos LG, Guilak F. Determination of the Poisson's ratio of the cell: recovery properties of chondrocytes after release from complete micropipette aspiration. Journal of Biomechanics. 39: 78-87. PMID 16271590 DOI: 10.1016/J.Jbiomech.2004.11.006  0.814
2006 Merryman WD, Youn I, Lukoff HD, Krueger PM, Guilak F, Hopkins RA, Sacks MS. Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis. American Journal of Physiology. Heart and Circulatory Physiology. 290: H224-31. PMID 16126816 DOI: 10.1152/Ajpheart.00521.2005  0.645
2006 Betre H, Ong SR, Guilak F, Chilkoti A, Fermor B, Setton LA. Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide. Biomaterials. 27: 91-9. PMID 16023192 DOI: 10.1016/J.Biomaterials.2005.05.071  0.593
2006 Guilak F, Lott KE, Awad HA, Cao Q, Hicok KC, Fermor B, Gimble JM. Clonal analysis of the differentiation potential of human adipose-derived adult stem cells. Journal of Cellular Physiology. 206: 229-37. PMID 16021633 DOI: 10.1002/Jcp.20463  0.627
2006 Griffin TM, Yan Z, Guilak F. Voluntary Exercise and the Development of Osteoarthritis in Mice Fed a High-fat Diet Medicine & Science in Sports & Exercise. 38: S26. DOI: 10.1249/00005768-200611001-00101  0.54
2006 Furman BD, Olson SA, Guilak F. El desarrollo de artritis postraumática después de fractura articular Journal of Orthopaedic Trauma. 20: 747. DOI: 10.1097/01.Bot.0000253104.97588.6C  0.351
2006 Upton M, Guilak F, Laursen T, Setton L. Biphasic finite element predictions for region-specific meniscus cell-matrix mechanics Journal of Biomechanics. 39: S407. DOI: 10.1016/S0021-9290(06)84651-8  0.553
2006 Gilchrist G, Witvoet-Braam S, Guilak F, Setton L. Intracellular measurements of strain transfer using texture correlation Journal of Biomechanics. 39: S228-S229. DOI: 10.1016/S0021-9290(06)83846-7  0.49
2006 Cao L, Youn I, Flahiff C, Li Y, Guilak F, Olsen B, Setton L. Altered cartilage mechanics in knee joints of type IX collagen deficient mice Journal of Biomechanics. 39: S23. DOI: 10.1016/S0021-9290(06)82959-3  0.737
2006 Trickey WR, Baaijens FPT, Laursen TA, Alexopoulos LG, Guilak F. Response to Dr. Schachar Journal of Biomechanics. 39: 2344-2345. DOI: 10.1016/J.Jbiomech.2006.06.002  0.756
2005 Alexopoulos LG, Setton LA, Guilak F. The biomechanical role of the chondrocyte pericellular matrix in articular cartilage. Acta Biomaterialia. 1: 317-25. PMID 16701810 DOI: 10.1016/J.Actbio.2005.02.001  0.751
2005 Guilak F, Alexopoulos LG, Haider MA, Ting-Beall HP, Setton LA. Zonal uniformity in mechanical properties of the chondrocyte pericellular matrix: micropipette aspiration of canine chondrons isolated by cartilage homogenization. Annals of Biomedical Engineering. 33: 1312-8. PMID 16240080 DOI: 10.1007/S10439-005-4479-7  0.753
2005 Griffin TM, Guilak F. The role of mechanical loading in the onset and progression of osteoarthritis. Exercise and Sport Sciences Reviews. 33: 195-200. PMID 16239837 DOI: 10.1097/00003677-200510000-00008  0.627
2005 Piscoya JL, Fermor B, Kraus VB, Stabler TV, Guilak F. The influence of mechanical compression on the induction of osteoarthritis-related biomarkers in articular cartilage explants Osteoarthritis and Cartilage. 13: 1092-1099. PMID 16168680 DOI: 10.1016/J.Joca.2005.07.003  0.373
2005 Fermor B, Weinberg JB, Pisetsky DS, Guilak F. The influence of oxygen tension on the induction of nitric oxide and prostaglandin E2 by mechanical stress in articular cartilage. Osteoarthritis and Cartilage. 13: 935-41. PMID 15975834 DOI: 10.1016/J.Joca.2005.05.001  0.321
2005 Xiao Z, Awad HA, Liu S, Mahlios J, Zhang S, Guilak F, Mayo MS, Quarles LD. Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice. Developmental Biology. 283: 345-56. PMID 15936013 DOI: 10.1016/J.Ydbio.2005.04.028  0.549
2005 Guilak F. The slippery slope of arthritis. Arthritis and Rheumatism. 52: 1632-3. PMID 15934074 DOI: 10.1002/Art.21051  0.374
2005 Baaijens FP, Trickey WR, Laursen TA, Guilak F. Large deformation finite element analysis of micropipette aspiration to determine the mechanical properties of the chondrocyte. Annals of Biomedical Engineering. 33: 494-501. PMID 15909655 DOI: 10.1007/S10439-005-2506-3  0.795
2005 Magnussen RA, Guilak F, Vail TP. Cartilage degeneration in post-collapse cases of osteonecrosis of the human femoral head: altered mechanical properties in tension, compression, and shear. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 23: 576-83. PMID 15885478 DOI: 10.1016/J.Orthres.2004.12.006  0.383
2005 Liu S, Brown TA, Zhou J, Xiao ZS, Awad H, Guilak F, Quarles LD. Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia. Journal of the American Society of Nephrology : Jasn. 16: 1645-53. PMID 15843468 DOI: 10.1681/Asn.2004121060  0.575
2005 Wang DW, Fermor B, Gimble JM, Awad HA, Guilak F. Influence of oxygen on the proliferation and metabolism of adipose derived adult stem cells. Journal of Cellular Physiology. 204: 184-91. PMID 15754341 DOI: 10.1002/Jcp.20324  0.639
2005 Tognana E, Chen F, Padera RF, Leddy HA, Christensen SE, Guilak F, Vunjak-Novakovic G, Freed LE. Adjacent tissues (cartilage, bone) affect the functional integration of engineered calf cartilage in vitro. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 13: 129-38. PMID 15694574 DOI: 10.1016/J.Joca.2004.10.015  0.802
2005 Alexopoulos LG, Williams GM, Upton ML, Setton LA, Guilak F. Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage. Journal of Biomechanics. 38: 509-17. PMID 15652549 DOI: 10.1016/J.Jbiomech.2004.04.012  0.751
2004 Fermor B, Jeffcoat D, Hennerbichler A, Pisetsky DS, Weinberg JB, Guilak F. The effects of cyclic mechanical strain and tumor necrosis factor alpha on the response of cells of the meniscus. Osteoarthritis and Cartilage. 12: 956-62. PMID 15564062 DOI: 10.1016/J.Joca.2004.08.007  0.31
2004 Guilak F, Awad HA, Fermor B, Leddy HA, Gimble JM. Adipose-derived adult stem cells for cartilage tissue engineering. Biorheology. 41: 389-99. PMID 15299271  0.809
2004 Leddy HA, Awad HA, Guilak F. Molecular diffusion in tissue-engineered cartilage constructs: effects of scaffold material, time, and culture conditions. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 70: 397-406. PMID 15264325 DOI: 10.1002/Jbm.B.30053  0.791
2004 Guilak F, Fermor B, Keefe FJ, Kraus VB, Olson SA, Pisetsky DS, Setton LA, Weinberg JB. The role of biomechanics and inflammation in cartilage injury and repair. Clinical Orthopaedics and Related Research. 17-26. PMID 15232421 DOI: 10.1097/01.Blo.0000131233.83640.91  0.624
2004 Estes BT, Gimble JM, Guilak F. Mechanical signals as regulators of stem cell fate. Current Topics in Developmental Biology. 60: 91-126. PMID 15094297 DOI: 10.1016/S0070-2153(04)60004-4  0.737
2004 Awad HA, Wickham MQ, Leddy HA, Gimble JM, Guilak F. Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. Biomaterials. 25: 3211-22. PMID 14980416 DOI: 10.1016/J.Biomaterials.2003.10.045  0.814
2004 Pritchard S, Guilak F. The role of F-actin in hypo-osmotically induced cell volume change and calcium signaling in anulus fibrosus cells. Annals of Biomedical Engineering. 32: 103-11. PMID 14964726 DOI: 10.1023/B:Abme.0000007795.69001.35  0.713
2004 Trickey WR, Vail TP, Guilak F. The role of the cytoskeleton in the viscoelastic properties of human articular chondrocytes. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 22: 131-9. PMID 14656671 DOI: 10.1016/S0736-0266(03)00150-5  0.819
2004 Gimble J, Guilak F. Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy. 5: 362-9. PMID 14578098 DOI: 10.1080/14653240310003026  0.391
2003 Gimble JM, Guilak F. Differentiation potential of adipose derived adult stem (ADAS) cells. Current Topics in Developmental Biology. 58: 137-60. PMID 14711015 DOI: 10.1016/S0070-2153(03)58005-X  0.384
2003 Awad HA, Halvorsen YD, Gimble JM, Guilak F. Effects of transforming growth factor beta1 and dexamethasone on the growth and chondrogenic differentiation of adipose-derived stromal cells. Tissue Engineering. 9: 1301-12. PMID 14670117 DOI: 10.1089/10763270360728215  0.574
2003 Upton ML, Chen J, Guilak F, Setton LA. Differential effects of static and dynamic compression on meniscal cell gene expression. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 21: 963-9. PMID 14554206 DOI: 10.1016/S0736-0266(03)00063-9  0.57
2003 Leddy HA, Guilak F. Site-specific molecular diffusion in articular cartilage measured using fluorescence recovery after photobleaching. Annals of Biomedical Engineering. 31: 753-60. PMID 12971608 DOI: 10.1114/1.1581879  0.687
2003 Alexopoulos LG, Haider MA, Vail TP, Guilak F. Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis. Journal of Biomechanical Engineering. 125: 323-33. PMID 12929236 DOI: 10.1115/1.1579047  0.661
2003 Wickham MQ, Erickson GR, Gimble JM, Vail TP, Guilak F. Multipotent stromal cells derived from the infrapatellar fat pad of the knee. Clinical Orthopaedics and Related Research. 196-212. PMID 12838072 DOI: 10.1097/01.Blo.0000072467.53786.Ca  0.816
2003 Shin SJ, Fermor B, Weinberg JB, Pisetsky DS, Guilak F. Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide. Journal of Applied Physiology (Bethesda, Md. : 1985). 95: 308-13. PMID 12665533 DOI: 10.1152/Japplphysiol.00131.2003  0.324
2003 Baer AE, Laursen TA, Guilak F, Setton LA. The micromechanical environment of intervertebral disc cells determined by a finite deformation, anisotropic, and biphasic finite element model. Journal of Biomechanical Engineering. 125: 1-11. PMID 12661192 DOI: 10.1115/1.1532790  0.585
2003 Erickson GR, Northrup DL, Guilak F. Hypo-osmotic stress induces calcium-dependent actin reorganization in articular chondrocytes. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 11: 187-97. PMID 12623290 DOI: 10.1053/S1063-4584(02)00347-3  0.752
2002 Pritchard S, Erickson GR, Guilak F. Hyperosmotically induced volume change and calcium signaling in intervertebral disk cells: the role of the actin cytoskeleton. Biophysical Journal. 83: 2502-10. PMID 12414684 DOI: 10.1016/S0006-3495(02)75261-2  0.786
2002 Haider MA, Guilak F. An axisymmetric boundary integral model for assessing elastic cell properties in the micropipette aspiration contact problem. Journal of Biomechanical Engineering. 124: 586-95. PMID 12405602 DOI: 10.1115/1.1504444  0.328
2002 Wyland DJ, Guilak F, Elliott DM, Setton LA, Vail TP. Chondropathy after meniscal tear or partial meniscectomy in a canine model. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 20: 996-1002. PMID 12382965 DOI: 10.1016/S0736-0266(02)00022-0  0.598
2002 Fermor B, Weinberg JB, Pisetsky DS, Misukonis MA, Fink C, Guilak F. Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway. Osteoarthritis and Cartilage. 10: 792-8. PMID 12359165 DOI: 10.1053/Joca.2002.0832  0.302
2002 Flahiff CM, Narmoneva DA, Huebner JL, Kraus VB, Guilak F, Setton LA. Osmotic loading to determine the intrinsic material properties of guinea pig knee cartilage. Journal of Biomechanics. 35: 1285-90. PMID 12163318 DOI: 10.1016/S0021-9290(02)00079-9  0.606
2002 Guilak F, Kapur R, Sefton MV, Vandenburgh HH, Koretsky AP, Kriete A, O'Keefe RJ. Functional assessment of engineered tissues and elements of tissue design: breakout session summary. Annals of the New York Academy of Sciences. 961: 207-9. PMID 12081902 DOI: 10.1111/J.1749-6632.2002.Tb03086.X  0.333
2002 Guilak F. Functional tissue engineering: the role of biomechanics in reparative medicine. Annals of the New York Academy of Sciences. 961: 193-5. PMID 12081896 DOI: 10.1111/J.1749-6632.2002.Tb03080.X  0.331
2002 Cernanec J, Guilak F, Weinberg JB, Pisetsky DS, Fermor B. Influence of hypoxia and reoxygenation on cytokine-induced production of proinflammatory mediators in articular cartilage. Arthritis and Rheumatism. 46: 968-75. PMID 11953974 DOI: 10.1002/Art.10213  0.37
2002 Elliott DM, Jones R, Setton LA, Scully SP, Vail TP, Guilak F. Joint degeneration following meniscal allograft transplantation in a canine model: mechanical properties and semiquantitative histology of articular cartilage. Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the Esska. 10: 109-18. PMID 11914769 DOI: 10.1007/S001670100227  0.566
2002 Alexopoulos LG, Erickson GR, Guilak F. A method for quantifying cell size from differential interference contrast images: validation and application to osmotically stressed chondrocytes. Journal of Microscopy. 205: 125-35. PMID 11879427 DOI: 10.1046/J.0022-2720.2001.00976.X  0.779
2002 Carlson CS, Guilak F, Vail TP, Gardin JF, Kraus VB. Synovial fluid biomarker levels predict articular cartilage damage following complete medial meniscectomy in the canine knee. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 20: 92-100. PMID 11853096 DOI: 10.1016/S0736-0266(01)00066-3  0.337
2002 Kraus VB, Huebner JL, Fink C, King JB, Brown S, Vail TP, Guilak F. Urea as a passive transport marker for arthritis biomarker studies. Arthritis and Rheumatism. 46: 420-7. PMID 11840444 DOI: 10.1002/Art.10124  0.331
2002 Guilak F, Erickson GR, Ting-Beall HP. The effects of osmotic stress on the viscoelastic and physical properties of articular chondrocytes. Biophysical Journal. 82: 720-7. PMID 11806914 DOI: 10.1016/S0006-3495(02)75434-9  0.786
2002 Hewitt JD, Glisson RR, Guilak F, Vail TP. The mechanical properties of the human hip capsule ligaments. The Journal of Arthroplasty. 17: 82-9. PMID 11805930 DOI: 10.1054/Arth.2002.27674  0.343
2002 Erickson GR, Gimble JM, Franklin DM, Rice HE, Awad H, Guilak F. Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. Biochemical and Biophysical Research Communications. 290: 763-9. PMID 11785965 DOI: 10.1006/Bbrc.2001.6270  0.837
2001 Erickson GR, Alexopoulos LG, Guilak F. Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways. Journal of Biomechanics. 34: 1527-35. PMID 11716854 DOI: 10.1016/S0021-9290(01)00156-7  0.781
2001 Fermor B, Brice Weinberg J, Pisetsky DS, Misukonis MA, Banes AJ, Guilak F. The effects of static and intermittent compression on nitric oxide production in articular cartilage explants Journal of Orthopaedic Research. 19: 729-737. PMID 11518285 DOI: 10.1016/S0736-0266(00)00049-8  0.303
2001 Fink C, Fermor B, Weinberg JB, Pisetsky DS, Misukonis MA, Guilak F. The effect of dynamic mechanical compression on nitric oxide production in the meniscus. Osteoarthritis and Cartilage. 9: 481-7. PMID 11467897 DOI: 10.1053/Joca.2001.0415  0.357
2001 Fermor B, Haribabu B, Weinberg JB, Pisetsky DS, Guilak F. Mechanical stress and nitric oxide influence leukotriene production in cartilage. Biochemical and Biophysical Research Communications. 285: 806-10. PMID 11453664 DOI: 10.1006/Bbrc.2001.5237  0.352
2001 Hewitt J, Guilak F, Glisson R, Vail TP. Regional material properties of the human hip joint capsule ligaments. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 19: 359-64. PMID 11398846 DOI: 10.1016/S0736-0266(00)00035-8  0.331
2001 Butler DL, Goldstein SA, Guilak F. Functional tissue engineering: the role of biomechanics. Journal of Biomechanical Engineering. 122: 570-5. PMID 11192376 DOI: 10.1115/1.1318906  0.423
2001 Guilak F, Butler DL, Goldstein SA. Functional Tissue Engineering Clinical Orthopaedics and Related Research. 391: S295-S305. DOI: 10.1097/00003086-200110001-00027  0.368
2000 Trickey WR, Lee GM, Guilak F. Viscoelastic properties of chondrocytes from normal and osteoarthritic human cartilage. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 18: 891-8. PMID 11192248 DOI: 10.1002/Jor.1100180607  0.822
2000 Guilak F, Mow VC. The mechanical environment of the chondrocyte: A biphasic finite element model of cell-matrix interactions in articular cartilage Journal of Biomechanics. 33: 1663-1673. PMID 11006391 DOI: 10.1016/S0021-9290(00)00105-6  0.601
2000 LeRoux MA, Arokoski J, Vail TP, Guilak F, Hyttinen MM, Kiviranta I, Setton LA. Simultaneous changes in the mechanical properties, quantitative collagen organization, and proteoglycan concentration of articular cartilage following canine meniscectomy. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 18: 383-92. PMID 10937624 DOI: 10.1002/Jor.1100180309  0.598
2000 Guilak F, Hung CT, Vanderby R. J. Cell and tissue engineering Journal of Biomechanical Engineering. 122: 209. PMID 10923286 DOI: 10.1115/1.429649  0.559
2000 Guilak F, Tedrow JR, Burgkart R. Viscoelastic properties of the cell nucleus. Biochemical and Biophysical Research Communications. 269: 781-6. PMID 10720492 DOI: 10.1006/Bbrc.2000.2360  0.356
2000 Lindhorst E, Vail TP, Guilak F, Wang H, Setton LA, Vilim V, Kraus VB. Longitudinal Characterization of Synovial Fluid Biomarkers in the Canine Meniscectomy Model of Osteoarthritis The Journal of Bone and Joint Surgery-American Volume. 82: 80. DOI: 10.2106/00004623-200006000-00051  0.528
2000 Elliott DM, Guilak F, Vail TP, Wang JY, Setton LA. Tensile Properties of Articular Cartilage are Altered by Meniscectomy in a Canine Model of Osteoarthritis The Journal of Bone and Joint Surgery-American Volume. 82: 54. DOI: 10.2106/00004623-200001000-00041  0.603
1999 Guilak F, Ting-Beall HP, Baer AE, Trickey WR, Erickson GR, Setton LA. Viscoelastic properties of intervertebral disc cells. Identification of two biomechanically distinct cell populations. Spine. 24: 2475-83. PMID 10626310 DOI: 10.1097/00007632-199912010-00009  0.809
1999 Setton LA, Guilak F, Hsu EW, Vail TP. Biomechanical factors in tissue engineered meniscal repair Clinical Orthopaedics and Related Research. S254-S272. PMID 10546651 DOI: 10.1097/00003086-199910001-00025  0.614
1999 Elliott DM, Guilak F, Vail TP, Wang JY, Setton LA. Tensile properties of articular cartilage are altered by meniscectomy in a canine model of osteoarthritis Journal of Orthopaedic Research. 17: 503-508. PMID 10459755 DOI: 10.1002/Jor.1100170407  0.62
1999 LeRoux MA, Guilak F, Setton LA. Compressive and shear properties of alginate gel: effects of sodium ions and alginate concentration. Journal of Biomedical Materials Research. 47: 46-53. PMID 10400879 DOI: 10.1002/(Sici)1097-4636(199910)47:1<46::Aid-Jbm6>3.0.Co;2-N  0.537
1999 Guilak F, Zell RA, Erickson GR, Grande DA, Rubin CT, McLeod KJ, Donahue HJ. Mechanically induced calcium waves in articular chondrocytes are inhibited by gadolinium and amiloride. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 17: 421-9. PMID 10376733 DOI: 10.2106/00004623-199911000-00023  0.76
1999 Guilak F, Jones WR, Ting-Beall HP, Lee GM. The deformation behavior and mechanical properties of chondrocytes in articular cartilage. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 7: 59-70. PMID 10367015 DOI: 10.1053/Joca.1998.0162  0.375
1999 Jones WR, Ting-Beall HP, Lee GM, Kelley SS, Hochmuth RM, Guilak F. Alterations in the Young's modulus and volumetric properties of chondrocytes isolated from normal and osteoarthritic human cartilage. Journal of Biomechanics. 32: 119-27. PMID 10052916 DOI: 10.1016/S0021-9290(98)00166-3  0.417
1998 Vail TP, Glisson RR, Koukoubis TD, Guilak F. The effect of hip stem material modulus on surface strain in human femora Journal of Biomechanics. 31: 619-628. PMID 9796684 DOI: 10.1016/S0021-9290(98)00061-X  0.317
1998 Bachrach NM, Mow VC, Guilak F. Incompressibility of the solid matrix of articular cartilage under high hydrostatic pressures Journal of Biomechanics. 31: 445-451. PMID 9727342 DOI: 10.1016/S0021-9290(98)00035-9  0.562
1996 Rubin C, Gross T, Qin YX, Fritton S, Guilak F, McLeod K. Differentiation of the bone-tissue remodeling response to axial and torsional loading in the turkey ulna. The Journal of Bone and Joint Surgery. American Volume. 78: 1523-33. PMID 8876580 DOI: 10.2106/00004623-199610000-00010  0.308
1995 Guilak F. Compression-induced changes in the shape and volume of the chondrocyte nucleus Journal of Biomechanics. 28: 1529-1541. PMID 8666592 DOI: 10.1016/0021-9290(95)00100-X  0.342
1995 Guilak F, Ratcliffe A, Mow VC. Chondrocyte deformation and local tissue strain in articular cartilage: A confocal microscopy study Journal of Orthopaedic Research. 13: 410-421. PMID 7602402 DOI: 10.1002/Jor.1100130315  0.595
1995 Donahue HJ, Guilak F, Vander Molen MA, McLeod KJ, Rubin CT, Grande DA, Brink PR. Chondrocytes isolated from mature articular cartilage retain the capacity to form functional gap junctions. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 10: 1359-64. PMID 7502708 DOI: 10.1002/Jbmr.5650100913  0.332
1994 Guilak F, Meyer BC, Ratcliffe A, Mow VC. The effects of matrix compression on proteoglycan metabolism in articular cartilage explants Osteoarthritis and Cartilage. 2: 91-101. PMID 11548233 DOI: 10.1016/S1063-4584(05)80059-7  0.499
1994 Best BA, Guilak F, Setton LA, Zhu W, Saed-Nejad F, Ratcliffe A, Weidenbaum M, Van M. Compressive mechanical properties of the human anulus fibrosus and their relationship to biochemical composition Spine. 19: 212-221. PMID 8153833 DOI: 10.1097/00007632-199401001-00017  0.515
1994 Guilak F, Ratcliffe A, Lane N, Rosenwasser MP, Mow VC. Mechanical and biochemical changes in the superficial zone of articular cartilage in canine experimental osteoarthritis Journal of Orthopaedic Research. 12: 474-484. PMID 8064478 DOI: 10.1002/Jor.1100120404  0.612
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