Daniela Salvemini - Publications

Affiliations: 
Anatomy Saint Louis University, St. Louis, MO, United States 
Area:
Neuroscience Biology, Behavioral Sciences Psychology, Pharmacology

174 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Sgambellone S, Marri S, Catarinicchia S, Pini A, Tosh DK, Jacobson KA, Masini E, Salvemini D, Lucarini L. Adenosine A Receptor (AAR) Agonist for the Treatment of Bleomycin-Induced Lung Fibrosis in Mice. International Journal of Molecular Sciences. 23. PMID 36362112 DOI: 10.3390/ijms232113300  0.38
2022 Wen Z, Salmaso V, Jung YH, Phung NB, Gopinatth V, Shah Q, Patterson AT, Randle JCR, Chen Z, Salvemini D, Lieberman DI, Whitehead GS, Karcz TP, Cook DN, Jacobson KA. Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2YR Antagonist. Journal of Medicinal Chemistry. PMID 35113556 DOI: 10.1021/acs.jmedchem.1c01964  0.362
2022 Singh AK, Mahalingam R, Squillace S, Jacobson KA, Tosh DK, Dharmaraj S, Farr SA, Kavelaars A, Salvemini D, Heijnen CJ. Targeting the A adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice. Acta Neuropathologica Communications. 10: 11. PMID 35093182 DOI: 10.1186/s40478-022-01315-w  0.445
2022 Braden K, Stratton HJ, Salvemini D, Khanna R. Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin-induced neuropathic pain. Neurobiology of Pain (Cambridge, Mass.). 11: 100082. PMID 35024498 DOI: 10.1016/j.ynpai.2021.100082  0.326
2021 Ilari S, Lauro F, Giancotti LA, Malafoglia V, Dagostino C, Gliozzi M, Condemi A, Maiuolo J, Oppedisano F, Palma E, Tomino C, Salvemini D, Mollace V, Muscoli C. The Protective Effect of Bergamot Polyphenolic Fraction (BPF) on Chemotherapy-Induced Neuropathic Pain. Pharmaceuticals (Basel, Switzerland). 14. PMID 34681199 DOI: 10.3390/ph14100975  0.333
2021 Coppi E, Cherchi F, Lucarini E, Ghelardini C, Pedata F, Jacobson KA, Di Cesare Mannelli L, Pugliese AM, Salvemini D. Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A Receptor Subtype. International Journal of Molecular Sciences. 22. PMID 34360719 DOI: 10.3390/ijms22157952  0.532
2021 Leduc-Pessah H, Xu C, Fan CY, Dalgarno R, Kohro Y, Sparanese S, Burke NN, Jacobson KA, Altier C, Salvemini D, Trang T. Spinal A adenosine receptor activation acutely restores morphine antinociception in opioid tolerant male rats. Journal of Neuroscience Research. PMID 34075613 DOI: 10.1002/jnr.24869  0.421
2021 Luongo L, Guida F, Maione S, Jacobson KA, Salvemini D. Adenosine Metabotropic Receptors in Chronic Pain Management. Frontiers in Pharmacology. 12: 651038. PMID 33935761 DOI: 10.3389/fphar.2021.651038  0.463
2021 Jung YH, Salmaso V, Wen Z, Bennett JM, Phung NB, Lieberman DI, Gopinatth V, Randle JCR, Chen Z, Salvemini D, Karcz TP, Cook DN, Jacobson KA. Structure-Activity Relationship of Heterocyclic P2Y Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres. Journal of Medicinal Chemistry. PMID 33787273 DOI: 10.1021/acs.jmedchem.1c00164  0.404
2021 Durante M, Squillace S, Lauro F, Giancotti LA, Coppi E, Cherchi F, Di Cesare Mannelli L, Ghelardini C, Kolar G, Wahlman C, Opejin A, Xiao C, Reitman ML, Tosh DK, Hawiger D, ... ... Salvemini D, et al. Adenosine A3 agonists reverse neuropathic pain via T cell-mediated production of IL-10. The Journal of Clinical Investigation. PMID 33621215 DOI: 10.1172/JCI139299  0.408
2020 Ilari S, Dagostino C, Malafoglia V, Lauro F, Giancotti LA, Spila A, Proietti S, Ventrice D, Rizzo M, Gliozzi M, Palma E, Guadagni F, Salvemini D, Mollace V, Muscoli C. Protective Effect of Antioxidants in Nitric Oxide/COX-2 Interaction during Inflammatory Pain: The Role of Nitration. Antioxidants (Basel, Switzerland). 9. PMID 33339104 DOI: 10.3390/antiox9121284  0.318
2020 Ilari S, Giancotti LA, Lauro F, Gliozzi M, Malafoglia V, Palma E, Tafani M, Russo MA, Tomino C, Fini M, Salvemini D, Mollace V, Muscoli C. Natural Antioxidant Control of Neuropathic Pain-Exploring the Role of Mitochondrial SIRT3 Pathway. Antioxidants (Basel, Switzerland). 9. PMID 33182469 DOI: 10.3390/antiox9111103  0.318
2020 Doyle TM, Hutchinson MR, Braden K, Janes K, Staikopoulos V, Chen Z, Neumann WL, Spiegel S, Salvemini D. Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents. Journal of Neuroinflammation. 17: 314. PMID 33092620 DOI: 10.1186/s12974-020-01975-2  0.606
2020 Squillace S, Spiegel S, Salvemini D. Targeting the Sphingosine-1-Phosphate Axis for Developing Non-narcotic Pain Therapeutics. Trends in Pharmacological Sciences. PMID 33010954 DOI: 10.1016/j.tips.2020.09.006  0.317
2020 Braden K, Giancotti LA, Chen Z, DeLeon C, Latzo N, Boehm T, D'Cunha N, Thompson BM, Doyle TM, McDonald JG, Walker JK, Kolar GR, Arnatt CK, Salvemini D. GPR183-oxysterol axis in spinal cord contributes to neuropathic pain. The Journal of Pharmacology and Experimental Therapeutics. PMID 32913007 DOI: 10.1124/Jpet.120.000105  0.454
2020 Jung YH, Yu J, Wen Z, Salmaso V, Karcz TP, Phung NB, Chen Z, Duca S, Bennett JM, Dudas S, Salvemini D, Gao ZG, Cook DN, Jacobson KA. Exploration of Alternative Scaffolds for P2Y Receptor Antagonists Containing a Biaryl Core. Journal of Medicinal Chemistry. PMID 32787142 DOI: 10.1021/Acs.Jmedchem.0C00745  0.501
2020 Suresh RR, Jain S, Chen Z, Tosh DK, Ma Y, Podszun MC, Rotman Y, Salvemini D, Jacobson KA. Design and in vivo activity of A adenosine receptor agonist prodrugs. Purinergic Signalling. PMID 32720036 DOI: 10.1007/S11302-020-09715-0  0.484
2020 Mufti F, Jung YH, Giancotti LA, Yu J, Chen Z, Phung NB, Jacobson KA, Salvemini D. P2Y Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model. Acs Medicinal Chemistry Letters. 11: 1281-1286. PMID 32551012 DOI: 10.1021/Acsmedchemlett.0C00115  0.566
2020 Doyle TM, Largent-Milnes TM, Chen Z, Staikopoulos V, Esposito E, Delgarno R, Fan C, Tosh DK, Cuzzocrea S, Jacobson KA, Trang T, Hutchinson MR, Bennett GJ, Vanderah TW, Salvemini D. The Journal of Pharmacology and Experimental Therapeutics. PMID 32434943 DOI: 10.1124/Jpet.120.000004  0.562
2020 Ilari S, Giancotti LA, Lauro F, Dagostino C, Gliozzi M, Malafoglia V, Sansone L, Palma E, Tafani M, Russo MA, Tomino C, Fini M, Salvemini D, Mollace V, Muscoli C. Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control. Pharmacological Research. 157: 104851. PMID 32423865 DOI: 10.1016/J.Phrs.2020.104851  0.401
2020 Lucarini E, Coppi E, Micheli L, Parisio C, Vona A, Cherchi F, Pugliese AM, Pedata F, Failli P, Palomino S, Wahl J, Largent-Milnes TM, Vanderah TW, Tosh DK, Jacobson KA, ... Salvemini D, et al. Acute visceral pain relief mediated by A3AR agonists in rats: involvement of N-type voltage-gated calcium channels. Pain. PMID 32379223 DOI: 10.1097/J.Pain.0000000000001905  0.561
2020 Doyle TM, Janes K, Chen Z, Grace PM, Esposito E, Cuzzocrea S, Largent-Milnes TM, Neumann WL, Watkins LR, Spiegel S, Vanderah TW, Salvemini D. Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents. Pain. PMID 32301840 DOI: 10.1097/J.Pain.0000000000001888  0.667
2020 Jacobson KA, Giancotti LA, Lauro F, Mufti F, Salvemini D. Treatment of chronic neuropathic pain: purine receptor modulation. Pain. PMID 32187120 DOI: 10.1097/J.Pain.0000000000001857  0.584
2020 Yosten GL, Harada CM, Haddock CJ, Giancotti LA, Kolar GR, Patel R, Guo C, Chen Z, Zhang J, Doyle TM, Dickenson AH, Samson WK, Salvemini D. GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents. The Journal of Clinical Investigation. PMID 31999650 DOI: 10.1172/Jci133270  0.429
2020 Latzo NG, Braden K, Giancotti L, Chen Z, DeLeon C, Boehm T, D’Cunha N, Luongo L, Doyle T, Kolar G, Walker J, Arnatt C, Salvemini D. Development of GPR183 Antagonists to Treat Neuropathic Pain The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.09724  0.428
2019 Stockstill K, Wahlman C, Braden K, Chen Z, Yosten GL, Tosh DK, Jacobson KA, Doyle TM, Samson WK, Salvemini D. Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents. Pain. PMID 31490328 DOI: 10.1097/J.Pain.0000000000001697  0.551
2019 Gliozzi M, Scicchitano M, Bosco F, Musolino V, Carresi C, Scarano F, Maiuolo J, Nucera S, Maretta A, Paone S, Mollace R, Ruga S, Zito MC, Macrì R, Oppedisano F, ... ... Salvemini D, et al. Modulation of Nitric Oxide Synthases by Oxidized LDLs: Role in Vascular Inflammation and Atherosclerosis Development. International Journal of Molecular Sciences. 20. PMID 31277498 DOI: 10.3390/Ijms20133294  0.324
2019 Chen Z, Doyle TM, Luongo L, Largent-Milnes TM, Giancotti LA, Kolar G, Squillace S, Boccella S, Walker JK, Pendleton A, Spiegel S, Neumann WL, Vanderah TW, Salvemini D. Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America. PMID 31068460 DOI: 10.1073/Pnas.1820466116  0.375
2019 Coppi E, Cherchi F, Fusco I, Failli P, Vona A, Dettori I, Gaviano L, Lucarini E, Jacobson KA, Tosh DK, Salvemini D, Ghelardini C, Pedata F, Di Cesare Mannelli L, Pugliese AM. Adenosine A3 receptor activation inhibits pronociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons. Pain. 160: 1103-1118. PMID 31008816 DOI: 10.1097/J.Pain.0000000000001488  0.503
2019 Coppi E, Cherchi F, Fusco I, Failli P, Vona A, Dettori I, Gaviano L, Lucarini E, Jacobson KA, Tosh DK, Salvemini D, Ghelardini C, Pedata F, Di Cesare Mannelli L, Pugliese AM. Title: Adenosine A3 receptor activation inhibits pro-nociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons. Pain. PMID 30938716 DOI: 10.1097/j.pain.0000000000001488  0.434
2018 Stockstill K, Doyle TM, Yan X, Chen Z, Janes K, Little JW, Braden K, Lauro F, Giancotti LA, Harada CM, Yadav R, Xiao WH, Lionberger JM, Neumann WL, Bennett GJ, ... ... Salvemini D, et al. Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain. The Journal of Experimental Medicine. PMID 29703731 DOI: 10.1084/Jem.20170584  0.733
2018 Luongo L, Salvemini D. Targeting metabotropic adenosine receptors for neuropathic pain: focus on A2A. Brain, Behavior, and Immunity. PMID 29499304 DOI: 10.1016/J.Bbi.2018.02.014  0.417
2018 Touchette JC, Little JW, Wilken GH, Salvemini D, Macarthur H. The neurotoxin DSP-4 induces hyperalgesia in rats that is accompanied by spinal oxidative stress and cytokine production. Neuroscience. PMID 29421433 DOI: 10.1016/J.Neuroscience.2018.01.058  0.602
2018 Wahlman C, Doyle TM, Little JW, Luongo L, Janes K, Chen Z, Esposito E, Tosh DK, Cuzzocrea S, Jacobson KA, Salvemini D. Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels via astrocyte-dependent mechanisms. Pain. PMID 29419652 DOI: 10.1097/J.Pain.0000000000001177  0.757
2018 Squillace S, Durante M, Opejin A, Hawiger D, Tosh D, Jacobson K, Salvemini D. CD4 + T cells and IL-10 are required for the beneficial effects exerted by A 3 AR agonists in neuropathic pain The Journal of Pain. 19: S81-S82. DOI: 10.1016/J.Jpain.2017.12.197  0.51
2017 Salvemini D, Jacobson KA. Highly selective A3 adenosine receptor agonists relieve chronic neuropathic pain. Expert Opinion On Therapeutic Patents. PMID 28604241 DOI: 10.1080/13543776.2017.1341018  0.555
2017 Grenald SA, Doyle TM, Zhang H, Slosky LM, Chen Z, Largent-Milnes TM, Spiegel S, Vanderah TW, Salvemini D. Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation. Pain. PMID 28570482 DOI: 10.1097/J.Pain.0000000000000965  0.393
2017 Petrelli R, Scortichini M, Kachler S, Boccella S, Cerchia C, Torquati I, Del Bello F, Salvemini D, Novellino E, Luongo L, Maione S, Jacobson KA, Lavecchia A, Klotz KN, Cappellacci L. Exploring the role of N(6)-substituents in potent dual acting 5'-C-ethyl-tetrazolyl-adenosine derivatives: synthesis, binding, functional assays and antinociceptive effects in mice. Journal of Medicinal Chemistry. PMID 28447789 DOI: 10.1021/Acs.Jmedchem.7B00291  0.519
2017 Tosh DK, Janowsky A, Eshleman AJ, Warnick E, Gao ZG, Chen Z, Gizewski E, Auchampach JA, Salvemini D, Jacobson KA. Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters. Journal of Medicinal Chemistry. PMID 28319392 DOI: 10.1021/Acs.Jmedchem.7B00141  0.449
2017 Durante M, Squillace S, Stockstill K, Wahlman C, Masini E, Tosh D, Jacobson K, Salvemini D. (193) Contribution of IL-10 and T cells in beneficial effects exerted by A 3 adenosine receptor agonists in blocking and reversing neuropathic pain The Journal of Pain. 18: S24. DOI: 10.1016/J.Jpain.2017.02.100  0.552
2017 Zhang H, Doyle T, Grenald S, Jacobson K, Salvemini D, Vanderah T. (192) Targeting A3 adenosine receptor in HIV-1 gp120-induced neuropathic pain The Journal of Pain. 18: S24. DOI: 10.1016/J.Jpain.2017.02.099  0.45
2017 Harada C, Chen Z, Stockstill L, Wahlman C, Kolar G, Smason W, Yosten G, Salvemini D. (187) Identification of spinal GPR160 as a novel protein promoting chronic neuropathic pain states The Journal of Pain. 18: S23. DOI: 10.1016/J.Jpain.2017.02.094  0.381
2017 Doyle T, Chen Z, Salvemini D. (182) Sphingosine 1-phosphate receptor subtype 1: a neuroinflammatory rheostat of the spinal cord in the development of chronic pain The Journal of Pain. 18: S21-S22. DOI: 10.1016/J.Jpain.2017.02.089  0.394
2016 Grace PM, Gaudet AD, Staikopoulos V, Maier SF, Hutchinson MR, Salvemini D, Watkins LR. Nitroxidative Signaling Mechanisms in Pathological Pain. Trends in Neurosciences. PMID 27842920 DOI: 10.1016/J.Tins.2016.10.003  0.416
2016 Romero-Reyes M, Salvemini D. Cancer and orofacial pain. Medicina Oral, Patologia Oral Y Cirugia Bucal. 21: e665-e671. PMID 27694791 DOI: 10.4317/Medoral.21515  0.314
2016 Malafoglia V, Traversetti L, Del Grosso F, Scalici M, Lauro F, Russo V, Persichini T, Salvemini D, Mollace V, Fini M, Raffaeli W, Muscoli C, Colasanti M. Transient Receptor Potential Melastatin-3 (TRPM3) Mediates Nociceptive-Like Responses in Hydra vulgaris. Plos One. 11: e0151386. PMID 26974325 DOI: 10.1371/Journal.Pone.0151386  0.359
2016 Tosh DK, Ciancetta A, Warnick E, O'Connor R, Chen Z, Gizewski E, Crane S, Gao ZG, Auchampach JA, Salvemini D, Jacobson KA. Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists. Journal of Medicinal Chemistry. PMID 26890707 DOI: 10.1021/Acs.Jmedchem.5B01998  0.462
2016 Janes K, Symons-Liguori AM, Jacobson KA, Salvemini D. Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics. British Journal of Pharmacology. PMID 26804983 DOI: 10.1111/Bph.13446  0.705
2015 Carlin JL, Tosh DK, Xiao C, Pinol RA, Chen Z, Salvemini D, Gavrilova O, Jacobson KA, Reitman ML. Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice that is Dependent on Central Histamine H1 Receptors. The Journal of Pharmacology and Experimental Therapeutics. PMID 26606937 DOI: 10.1124/Jpet.115.229872  0.517
2015 Trang T, Al-Hasani R, Salvemini D, Salter MW, Gutstein H, Cahill CM. Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13879-88. PMID 26468188 DOI: 10.1523/Jneurosci.2711-15.2015  0.423
2015 Tosh DK, Paoletta S, Chen Z, Crane S, Lloyd J, Gao ZG, Gizewski ET, Auchampach JA, Salvemini D, Jacobson KA. Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists. Medchemcomm. 6: 555-563. PMID 26236460 DOI: 10.1039/C4Md00571F  0.533
2015 Tosh DK, Crane S, Chen Z, Paoletta S, Gao ZG, Gizewski E, Auchampach JA, Salvemini D, Jacobson KA. Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy. Acs Medicinal Chemistry Letters. 6: 804-8. PMID 26191370 DOI: 10.1021/Acsmedchemlett.5B00150  0.509
2015 Tosh DK, Padia J, Salvemini D, Jacobson KA. Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signalling. PMID 26111639 DOI: 10.1007/S11302-015-9459-2  0.549
2015 Luongo L, Malcangio M, Salvemini D, Starowicz K. Chronic pain: new insights in molecular and cellular mechanisms. Biomed Research International. 2015: 676725. PMID 25879035 DOI: 10.1155/2015/676725  0.401
2015 Ford A, Castonguay A, Cottet M, Little JW, Chen Z, Symons-Liguori AM, Doyle T, Egan TM, Vanderah TW, De Konnick Y, Tosh DK, Jacobson KA, Salvemini D. Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6057-67. PMID 25878279 DOI: 10.1523/Jneurosci.4495-14.2015  0.68
2015 Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S, Bannister K, Dickenson AH, Vanderah TW, Porreca F, Jacobson KA, ... Salvemini D, et al. Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain : a Journal of Neurology. 138: 28-35. PMID 25414036 DOI: 10.1093/Brain/Awu330  0.784
2015 Janes K, Wahlman C, Little JW, Doyle T, Tosh DK, Jacobson KA, Salvemini D. Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy. Brain, Behavior, and Immunity. 44: 91-9. PMID 25220279 DOI: 10.1016/J.Bbi.2014.08.010  0.774
2015 Tosh DK, Paoletta S, Chen Z, Crane S, Lloyd J, Gao ZG, Gizewski ET, Auchampach JA, Salvemini D, Jacobson KA. Structure-based design, synthesis by click chemistry and in vivo activity of highly selective A3 adenosine receptor agonists Medchemcomm. 6: 555-563. DOI: 10.1039/c4md00571f  0.396
2015 Lauro F, Ilari S, Giancotti LA, Morabito C, Malafoglia V, Gliozzi M, Palma E, Salvemini D, Muscoli C. The protective role of bergamot polyphenolic fraction on several animal models of pain Pharmanutrition. DOI: 10.1016/J.Phanu.2016.04.001  0.412
2015 Little J, Janes K, Chen Z, Wahlman C, Tosh D, Jacobson K, Salvemini D. (326) Supraspinal adenosine A3 receptor (A3AR) activation reverses chemotherapy-induced neuropathic pain through an IL-10 dependent mechanism The Journal of Pain. 16: S57. DOI: 10.1016/J.Jpain.2015.01.244  0.767
2015 Tosh DK, Padia J, Salvemini D, Jacobson KA. Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain Purinergic Signalling. DOI: 10.1007/s11302-015-9459-2  0.48
2014 Tosh DK, Finley A, Paoletta S, Moss SM, Gao ZG, Gizewski ET, Auchampach JA, Salvemini D, Jacobson KA. In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists. Journal of Medicinal Chemistry. 57: 9901-14. PMID 25422861 DOI: 10.1021/Jm501021N  0.551
2014 Janes K, Esposito E, Doyle T, Cuzzocrea S, Tosh DK, Jacobson KA, Salvemini D. A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways. Pain. 155: 2560-7. PMID 25242567 DOI: 10.1016/J.Pain.2014.09.016  0.745
2014 Mollace V, Muscoli C, Dagostino C, Giancotti LA, Gliozzi M, Sacco I, Visalli V, Gratteri S, Palma E, Malara N, Musolino V, Carresi C, Muscoli S, Vitale C, Salvemini D, et al. The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance. Pharmacological Research. 89: 29-35. PMID 25174989 DOI: 10.1016/J.Phrs.2014.07.007  0.351
2014 Tosh DK, Paoletta S, Chen Z, Moss SM, Gao ZG, Salvemini D, Jacobson KA. Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor. Bioorganic & Medicinal Chemistry Letters. 24: 3302-6. PMID 24969016 DOI: 10.1016/J.Bmcl.2014.06.006  0.507
2014 Janes K, Little JW, Li C, Bryant L, Chen C, Chen Z, Kamocki K, Doyle T, Snider A, Esposito E, Cuzzocrea S, Bieberich E, Obeid L, Petrache I, Nicol G, ... ... Salvemini D, et al. The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. The Journal of Biological Chemistry. 289: 21082-97. PMID 24876379 DOI: 10.1074/Jbc.M114.569574  0.762
2014 Rajagopalan P, Tracey H, Chen Z, Bandyopadhyaya A, Veeraraghavan S, Rajagopalan DR, Salvemini D, McPhee I, Viswanadha S, Rajagopalan R. DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain. Bioorganic & Medicinal Chemistry Letters. 24: 3088-91. PMID 24863744 DOI: 10.1016/J.Bmcl.2014.05.016  0.475
2014 Paoletta S, Tosh DK, Salvemini D, Jacobson KA. Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners. Plos One. 9: e97858. PMID 24859150 DOI: 10.1371/Journal.Pone.0097858  0.451
2014 Doyle T, Li C, Nicol G, Neumann W, Salvemini D. (341) Sphingosine 1-phosphate receptor 1 antagonism prevents morphine-induced antinociceptive tolerance and hyperalgesia The Journal of Pain. 15: S61. DOI: 10.1016/J.Jpain.2014.01.251  0.35
2014 Ilari S, Lauro F, Montagna C, Di Giacomo G, Rizza S, Cardaci S, Allegri M, De Gregori M, Dagostino C, Gliozzi M, Filomeni G, Salvemini D, Mollace V, Muscoli C. (339) Spontaneous pain response in S-nitrosoglutathione reductase (GSNOR) deficient mice: the role of S-nitrosylation The Journal of Pain. 15: S60. DOI: 10.1016/J.Jpain.2014.01.249  0.339
2014 Janes K, Doyle T, Cuzzocrea S, Bennett G, Salvemini D. (338) The role of peroxynitrite in peripheral nerve sensory axon mitotoxicity during chemotherapy-induced neuropathic pain The Journal of Pain. 15: S60. DOI: 10.1016/J.Jpain.2014.01.248  0.61
2014 Stockstill K, Janes K, Xiao W, Li C, Bryant L, Nicol G, Bennett G, Salvemini D. (337) Bortezomib-induced neuropathic pain is blocked and reversed by blocking the S1P/S1PR1 axis The Journal of Pain. 15: S60. DOI: 10.1016/J.Jpain.2014.01.247  0.652
2014 Maloy C, Janes K, Bryant L, Tosh D, Jacobson K, Salvemini D. (336) A3 adenosine receptor agonists reverse established oxaliplatin-induced neuropathic pain through an IL-10 mediated mechanism of action in spinal cord The Journal of Pain. 15: S60. DOI: 10.1016/J.Jpain.2014.01.246  0.713
2014 Little J, Chen Z, Ford A, Janes K, Doyle T, Tosh D, Jacobson K, Salvemini D. (297) Central adenosine A3 receptor (A3AR) activation reverses neuropathic pain The Journal of Pain. 15: S50. DOI: 10.1016/J.Jpain.2014.01.207  0.763
2013 Janes K, Doyle T, Bryant L, Esposito E, Cuzzocrea S, Ryerse J, Bennett GJ, Salvemini D. Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase. Pain. 154: 2432-40. PMID 23891899 DOI: 10.1016/J.Pain.2013.07.032  0.637
2013 Muscoli C, Dagostino C, Ilari S, Lauro F, Gliozzi M, Bardhi E, Palma E, Mollace V, Salvemini D. Posttranslational nitration of tyrosine residues modulates glutamate transmission and contributes to N-methyl-D-aspartate-mediated thermal hyperalgesia. Mediators of Inflammation. 2013: 950947. PMID 23864769 DOI: 10.1155/2013/950947  0.338
2013 Paoletta S, Tosh DK, Finley A, Gizewski ET, Moss SM, Gao ZG, Auchampach JA, Salvemini D, Jacobson KA. Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain. Journal of Medicinal Chemistry. 56: 5949-63. PMID 23789857 DOI: 10.1021/Jm4007966  0.518
2013 Little JW, Cuzzocrea S, Bryant L, Esposito E, Doyle T, Rausaria S, Neumann WL, Salvemini D. Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance. Pain. 154: 978-86. PMID 23590939 DOI: 10.1016/J.Pain.2013.02.018  0.623
2013 Doyle T, Esposito E, Bryant L, Cuzzocrea S, Salvemini D. NADPH-oxidase 2 activation promotes opioid-induced antinociceptive tolerance in mice. Neuroscience. 241: 1-9. PMID 23454539 DOI: 10.1016/J.Neuroscience.2013.02.042  0.355
2013 Salvemini D, Kim SF, Mollace V. Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 304: R473-87. PMID 23389111 DOI: 10.1152/Ajpregu.00355.2012  0.354
2013 Finley A, Chen Z, Esposito E, Cuzzocrea S, Sabbadini R, Salvemini D. Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism. Plos One. 8: e55255. PMID 23372844 DOI: 10.1371/Journal.Pone.0055255  0.38
2013 Salvemini D, Doyle T, Kress M, Nicol G. Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain. Trends in Pharmacological Sciences. 34: 110-8. PMID 23318139 DOI: 10.1016/J.Tips.2012.12.001  0.428
2013 Doyle T, Bryant L, Chen Z, Cuzzocrea S, Salvemini D. Morphine-induced antinociceptive tolerance and hyperalgesia is mediated through sphingosine 1-phosphate receptor 1-dependent p38 and neuroinflammatory mechanisms The Journal of Pain. 14: S42. DOI: 10.1016/J.Jpain.2013.01.503  0.353
2012 Little JW, Chen Z, Doyle T, Porreca F, Ghaffari M, Bryant L, Neumann WL, Salvemini D. Supraspinal peroxynitrite modulates pain signaling by suppressing the endogenous opioid pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10797-808. PMID 22875915 DOI: 10.1523/Jneurosci.6345-11.2012  0.645
2012 Doyle T, Chen Z, Muscoli C, Bryant L, Esposito E, Cuzzocrea S, Dagostino C, Ryerse J, Rausaria S, Kamadulski A, Neumann WL, Salvemini D. Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 6149-60. PMID 22553021 DOI: 10.1523/Jneurosci.6343-11.2012  0.469
2012 Chen Z, Janes K, Chen C, Doyle T, Bryant L, Tosh DK, Jacobson KA, Salvemini D. Controlling murine and rat chronic pain through A3 adenosine receptor activation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1855-65. PMID 22345405 DOI: 10.1096/Fj.11-201541  0.731
2012 Janes K, Neumann WL, Salvemini D. Anti-superoxide and anti-peroxynitrite strategies in pain suppression. Biochimica Et Biophysica Acta. 1822: 815-21. PMID 22200449 DOI: 10.1016/J.Bbadis.2011.12.008  0.659
2012 Little JW, Doyle T, Salvemini D. Reactive nitroxidative species and nociceptive processing: determining the roles for nitric oxide, superoxide, and peroxynitrite in pain. Amino Acids. 42: 75-94. PMID 20552384 DOI: 10.1007/S00726-010-0633-0  0.638
2011 Rausaria S, Ghaffari MM, Kamadulski A, Rodgers K, Bryant L, Chen Z, Doyle T, Shaw MJ, Salvemini D, Neumann WL. Retooling manganese(III) porphyrin-based peroxynitrite decomposition catalysts for selectivity and oral activity: a potential new strategy for treating chronic pain. Journal of Medicinal Chemistry. 54: 8658-69. PMID 22082008 DOI: 10.1021/Jm201233R  0.373
2011 Doyle T, Chen Z, Obeid LM, Salvemini D. Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia. Neuroscience Letters. 499: 4-8. PMID 21605625 DOI: 10.1016/J.Neulet.2011.05.018  0.373
2011 Samlowski WE, Kondapaneni M, Tharkar S, McGregor JR, Laubach VE, Salvemini D. Endothelial nitric oxide synthase is a key mediator of interleukin-2-induced hypotension and vascular leak syndrome. Journal of Immunotherapy (Hagerstown, Md. : 1997). 34: 419-27. PMID 21577143 DOI: 10.1097/Cji.0B013E31821Dcb50  0.324
2011 Doyle T, Chen Z, Muscoli C, Obeid LM, Salvemini D. Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2782-91. PMID 21551240 DOI: 10.1096/Fj.10-178095  0.345
2011 Salvemini D, Little JW, Doyle T, Neumann WL. Roles of reactive oxygen and nitrogen species in pain. Free Radical Biology & Medicine. 51: 951-66. PMID 21277369 DOI: 10.1016/J.Freeradbiomed.2011.01.026  0.623
2011 Doyle T, Finley A, Chen Z, Salvemini D. Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats. Pain. 152: 643-8. PMID 21239112 DOI: 10.1016/J.Pain.2010.12.011  0.405
2011 Nicol G, Langeslag M, Geisslinger G, Salvemini D, Kress M. 42 SPHINGOSINE 1-PHOSPHATE: REGULATOR OF INFLAMMATION AND PAIN European Journal of Pain Supplements. 5: 10-11. DOI: 10.1016/S1754-3207(11)70032-3  0.408
2011 Doyle T, Chen Z, Salvemini D. Peroxynitrite decomposition catalyst blocks paclitaxel-induced neuropathic pain: microarray analysis of spinal cord gene expression The Journal of Pain. 12: P37. DOI: 10.1016/J.Jpain.2011.02.148  0.357
2011 Little J, Chen Z, Doyle T, Porreca F, Salvemini D. Supraspinal descending facilitation of central sensitization depends on peroxynitrite regulation of opioid signaling The Journal of Pain. 12: P36. DOI: 10.1016/J.Jpain.2011.02.145  0.537
2010 Muscoli C, Doyle T, Dagostino C, Bryant L, Chen Z, Watkins LR, Ryerse J, Bieberich E, Neumman W, Salvemini D. Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15400-8. PMID 21084596 DOI: 10.1523/Jneurosci.2391-10.2010  0.41
2010 Doyle T, Bryant L, Muscoli C, Cuzzocrea S, Esposito E, Chen Z, Salvemini D. Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance. Neuroscience Letters. 483: 85-9. PMID 20637262 DOI: 10.1016/J.Neulet.2010.07.013  0.385
2010 Chen Z, Muscoli C, Doyle T, Bryant L, Cuzzocrea S, Mollace V, Mastroianni R, Masini E, Salvemini D. NMDA-receptor activation and nitroxidative regulation of the glutamatergic pathway during nociceptive processing. Pain. 149: 100-6. PMID 20167432 DOI: 10.1016/J.Pain.2010.01.015  0.36
2010 Salvemini D, Neumann W. Targeting peroxynitrite driven nitroxidative stress with synzymes: A novel therapeutic approach in chronic pain management. Life Sciences. 86: 604-14. PMID 19576230 DOI: 10.1016/J.Lfs.2009.06.011  0.431
2009 Bryant L, Doyle T, Chen Z, Cuzzocrea S, Masini E, Vinci MC, Esposito E, Mazzon E, Petrusca DN, Petrache I, Salvemini D. Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance. Neuroscience Letters. 463: 49-53. PMID 19631718 DOI: 10.1016/J.Neulet.2009.07.051  0.402
2009 Doyle T, Bryant L, Batinic-Haberle I, Little J, Cuzzocrea S, Masini E, Spasojevic I, Salvemini D. Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance Neuroscience. 164: 702-710. PMID 19607887 DOI: 10.1016/J.Neuroscience.2009.07.019  0.623
2009 Salvemini D, Neumann WL. Peroxynitrite: a strategic linchpin of opioid analgesic tolerance. Trends in Pharmacological Sciences. 30: 194-202. PMID 19261337 DOI: 10.1016/J.Tips.2008.12.005  0.419
2009 Ndengele MM, Cuzzocrea S, Masini E, Vinci MC, Esposito E, Muscoli C, Petrusca DN, Mollace V, Mazzon E, Li D, Petrache I, Matuschak GM, Salvemini D. Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation. The Journal of Pharmacology and Experimental Therapeutics. 329: 64-75. PMID 19033555 DOI: 10.1124/Jpet.108.146290  0.432
2009 Salvemini D. Peroxynitrite and opiate antinociceptive tolerance: a painful reality. Archives of Biochemistry and Biophysics. 484: 238-44. PMID 19017525 DOI: 10.1016/J.Abb.2008.11.005  0.406
2009 Batinić-Haberle I, Cuzzocrea S, Rebouças JS, Ferrer-Sueta G, Mazzon E, Di Paola R, Radi R, Spasojević I, Benov L, Salvemini D. Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy. Free Radical Biology & Medicine. 46: 192-201. PMID 19007878 DOI: 10.1016/J.Freeradbiomed.2008.09.042  0.308
2009 Batinić-Haberle I, Ndengele MM, Cuzzocrea S, Rebouças JS, Spasojević I, Salvemini D. Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways. Free Radical Biology & Medicine. 46: 212-9. PMID 18983908 DOI: 10.1016/J.Freeradbiomed.2008.09.037  0.407
2009 Cuzzocrea S, Deigner HP, Genovese T, Mazzon E, Esposito E, Crisafulli C, Di Paola R, Bramanti P, Matuschak G, Salvemini D. Inhibition of ceramide biosynthesis ameliorates pathological consequences of spinal cord injury. Shock (Augusta, Ga.). 31: 634-44. PMID 18838947 DOI: 10.1097/Shk.0B013E3181891396  0.303
2008 Cuzzocrea S, Di Paola R, Genovese T, Mazzon E, Esposito E, Crisafulli C, Bramanti P, Salvemini D. Anti-inflammatory and anti-apoptotic effects of fumonisin B1, an inhibitor of ceramide synthase, in a rodent model of splanchnic ischemia and reperfusion injury. The Journal of Pharmacology and Experimental Therapeutics. 327: 45-57. PMID 18612046 DOI: 10.1124/Jpet.108.139808  0.305
2008 Ndengele MM, Cuzzocrea S, Esposito E, Mazzon E, Di Paola R, Matuschak GM, Salvemini D. Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3154-64. PMID 18497304 DOI: 10.1096/Fj.08-108159  0.433
2008 Kondapaneni M, McGregor JR, Salvemini D, Laubach VE, Samlowski WE. Inducible nitric oxide synthase (iNOS) is not required for IL-2-induced hypotension and vascular leak syndrome in mice. Journal of Immunotherapy (Hagerstown, Md. : 1997). 31: 325-33. PMID 18391763 DOI: 10.1097/Cji.0B013E31816112E8  0.308
2008 Masini E, Giannini L, Nistri S, Cinci L, Mastroianni R, Xu W, Comhair SA, Li D, Cuzzocrea S, Matuschak GM, Salvemini D. Ceramide: a key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation. The Journal of Pharmacology and Experimental Therapeutics. 324: 548-57. PMID 18042827 DOI: 10.1124/Jpet.107.131565  0.315
2007 Muscoli C, Cuzzocrea S, Ndengele MM, Mollace V, Porreca F, Fabrizi F, Esposito E, Masini E, Matuschak GM, Salvemini D. Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice. The Journal of Clinical Investigation. 117: 3530-9. PMID 17975673 DOI: 10.1172/Jci32420  0.422
2007 Cuzzocrea S, Salvemini D. Molecular mechanisms involved in the reciprocal regulation of cyclooxygenase and nitric oxide synthase enzymes Kidney International. 71: 290-297. PMID 17200681 DOI: 10.1038/Sj.Ki.5002058  0.332
2006 Salvemini D, Doyle TM, Cuzzocrea S. Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation Biochemical Society Transactions. 34: 965-970. PMID 17052238 DOI: 10.1042/Bst0340965  0.33
2006 Cuzzocrea S, Mazzon E, Di Paola R, Esposito E, Macarthur H, Matuschak GM, Salvemini D. A role for nitric oxide-mediated peroxynitrite formation in a model of endotoxin-induced shock. The Journal of Pharmacology and Experimental Therapeutics. 319: 73-81. PMID 16815867 DOI: 10.1124/Jpet.106.108100  0.318
2005 Mollace V, Muscoli C, Masini E, Cuzzocrea S, Salvemini D. Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors. Pharmacological Reviews. 57: 217-52. PMID 15914468 DOI: 10.1124/Pr.57.2.1  0.36
2005 Ndengele MM, Muscoli C, Wang ZQ, Doyle TM, Matuschak GM, Salvemini D. Superoxide potentiates NF-kappaB activation and modulates endotoxin-induced cytokine production in alveolar macrophages. Shock (Augusta, Ga.). 23: 186-93. PMID 15665736 DOI: 10.1097/01.Shk.0000144130.36771.D6  0.308
2004 Muscoli C, Mollace V, Wheatley J, Masini E, Ndengele M, Wang ZQ, Salvemini D. Superoxide-mediated nitration of spinal manganese superoxide dismutase: a novel pathway in N-methyl-D-aspartate-mediated hyperalgesia. Pain. 111: 96-103. PMID 15327813 DOI: 10.1016/J.Pain.2004.06.004  0.394
2004 Muscoli C, Sacco I, Alecce W, Palma E, Nisticò R, Costa N, Clementi F, Rotiroti D, Romeo F, Salvemini D, Mehta JL, Mollace V. The protective effect of superoxide dismutase mimetic M40401 on balloon injury-related neointima formation: role of the lectin-like oxidized low-density lipoprotein receptor-1. The Journal of Pharmacology and Experimental Therapeutics. 311: 44-50. PMID 15220383 DOI: 10.1124/Jpet.104.068205  0.315
2004 Cuzzocrea S, Thiemermann C, Salvemini D. Potential therapeutic effect of antioxidant therapy in shock and inflammation. Current Medicinal Chemistry. 11: 1147-62. PMID 15134512 DOI: 10.2174/0929867043365396  0.347
2004 Wang ZQ, Porreca F, Cuzzocrea S, Galen K, Lightfoot R, Masini E, Muscoli C, Mollace V, Ndengele M, Ischiropoulos H, Salvemini D. A newly identified role for superoxide in inflammatory pain. The Journal of Pharmacology and Experimental Therapeutics. 309: 869-78. PMID 14988418 DOI: 10.1124/Jpet.103.064154  0.458
2004 Cuzzocrea S, Mazzon E, Dugo L, Di Paola R, Caputi AP, Salvemini D. Superoxide: A key player in hypertension Faseb Journal. 18: 94-101. PMID 14718390 DOI: 10.1096/Fj.03-0428Com  0.312
2003 Muscoli C, Cuzzocrea S, Riley DP, Zweier JL, Thiemermann C, Wang ZQ, Salvemini D. On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies. British Journal of Pharmacology. 140: 445-60. PMID 14522841 DOI: 10.1038/Sj.Bjp.0705430  0.301
2003 Fries DM, Paxinou E, Themistocleous M, Swanberg E, Griendling KK, Salvemini D, Slot JW, Heijnen HF, Hazen SL, Ischiropoulos H. Expression of inducible nitric-oxide synthase and intracellular protein tyrosine nitration in vascular smooth muscle cells: role of reactive oxygen species. The Journal of Biological Chemistry. 278: 22901-7. PMID 12690103 DOI: 10.1074/Jbc.M210806200  0.314
2003 Tuder RM, Zhen L, Cho CY, Taraseviciene-Stewart L, Kasahara Y, Salvemini D, Voelkel NF, Flores SC. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. American Journal of Respiratory Cell and Molecular Biology. 29: 88-97. PMID 12600822 DOI: 10.1165/Rcmb.2002-0228Oc  0.311
2003 Salvemini D, Cuzzocrea S. Therapeutic potential of superoxide dismutase mimetics as therapeutic agents in critical care medicine. Critical Care Medicine. 31: S29-38. PMID 12544974 DOI: 10.1097/00003246-200301001-00005  0.322
2003 Mollace V, Iannone M, Muscoli C, Palma E, Granato T, Rispoli V, Nisticò R, Rotiroti D, Salvemini D. The role of oxidative stress in paraquat-induced neurotoxicity in rats: protection by non peptidyl superoxide dismutase mimetic. Neuroscience Letters. 335: 163-6. PMID 12531458 DOI: 10.1016/S0304-3940(02)01168-0  0.318
2002 Salvemini D, Cuzzocrea S. Oxidative stress in septic shock and disseminated intravascular coagulation. Free Radical Biology & Medicine. 33: 1173-85. PMID 12398925 DOI: 10.1016/S0891-5849(02)00961-9  0.315
2002 Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Di Paola R, Britti D, De Sarro A, Pierpaoli S, Caputi A, Masini E, Salvemini D. A role for superoxide in gentamicin-mediated nephropathy in rats. European Journal of Pharmacology. 450: 67-76. PMID 12176111 DOI: 10.1016/S0014-2999(02)01749-1  0.306
2002 Mollace V, Muscoli C, Iannone M, Palma E, Rotiroti D, Romeo F, Nisticò R, Salvemini D. Dexamethasone inhibits the inducible bioconversion of glyceryl trinitrate to nitric oxide. Journal of Cardiovascular Pharmacology. 39: 544-51. PMID 11904528 DOI: 10.1097/00005344-200204000-00010  0.336
2001 Cuzzocrea S, Mazzon E, Dugo L, Caputi AP, Riley DP, Salvemini D. Protective effects of M40403, a superoxide dismutase mimetic, in a rodent model of colitis European Journal of Pharmacology. 432: 79-89. PMID 11734191 DOI: 10.1016/S0014-2999(01)01427-3  0.305
2001 Salvemini D, Mazzon E, Dugo L, Riley DP, Serraino I, Caputi AP, Cuzzocrea S. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403 British Journal of Pharmacology. 132: 815-827. PMID 11181422 DOI: 10.1038/Sj.Bjp.0703841  0.326
1999 Salvemini D, Riley DP, Lennon PJ, Wang ZQ, Currie MG, Macarthur H, Misko TP. Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage. British Journal of Pharmacology. 127: 685-92. PMID 10401559 DOI: 10.1038/Sj.Bjp.0702604  0.309
1998 Salvemini D, Marino MH. Inducible nitric oxide synthase and inflammation Expert Opinion On Investigational Drugs. 7: 65-75. DOI: 10.1517/13543784.7.1.65  0.326
1997 Salvemini D. Regulation of cyclooxygenase enzymes by nitric oxide Cellular and Molecular Life Sciences. 53: 576-582. PMID 9312403 DOI: 10.1007/S000180050074  0.327
1996 Salvemini D, Wang ZQ, Bourdon DM, Stern MK, Currie MG, Manning PT. Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema European Journal of Pharmacology. 303: 217-220. PMID 8813572 DOI: 10.1016/0014-2999(96)00140-9  0.348
1996 Salvemini D, Wang ZQ, Wyatt PS, Bourdon DM, Marino MH, Manning PT, Currie MG. Nitric oxide: A key mediator in the early and late phase of carrageenan-induced rat paw inflammation British Journal of Pharmacology. 118: 829-838. PMID 8799551 DOI: 10.1111/J.1476-5381.1996.Tb15475.X  0.341
1996 Salvemini D, Masferrer JL. Interactions of nitric oxide with cyclooxygenase: In vitro, ex vivo, and in vivo studies Methods in Enzymology. 269: 12-25. PMID 8791633 DOI: 10.1016/S0076-6879(96)69005-3  0.352
1996 Salvemini D, Currie MG, Mollace V. Nitric oxide-mediated cyclooxygenase activation. A key event in the antiplatelet effects of nitrovasodilators Journal of Clinical Investigation. 97: 2562-2568. PMID 8647949 DOI: 10.1172/Jci118704  0.365
1995 Salvemini D, Seibert K, Masferrer JL, Settle SL, Currie MG, Needleman P. Nitric Oxide Activates the Cyclooxygenase Pathway in Inflammation. American Journal of Therapeutics. 2: 616-619. PMID 11854836 DOI: 10.1097/00045391-199509000-00007  0.309
1995 Masferrer JL, Zweifel BS, Colburn SM, Ornberg RL, Salvemini D, Isakson P, Seibert K. The Role of Cyclooxygenase-2 in Inflammation. American Journal of Therapeutics. 2: 607-610. PMID 11854834 DOI: 10.1097/00045391-199509000-00005  0.308
1995 Salvemini D, Settle SL, Masferrer JL, Seibert K, Currie MG, Needleman P. Regulation of prostaglandin production by nitric oxide; an in vivo analysis. British Journal of Pharmacology. 114: 1171-8. PMID 7542531 DOI: 10.1111/J.1476-5381.1995.Tb13330.X  0.32
1995 Salvemini D, Manning PT, Zweifel BS, Seibert K, Connor J, Currie MG, Needleman P, Masferrer JL. Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors. The Journal of Clinical Investigation. 96: 301-8. PMID 7542281 DOI: 10.1172/Jci118035  0.349
1994 Pistelli A, Mollace V, Nistico G, Salvemini D, Vane J. Nitroblue tetrazolium inhibits oxidation of glyceryl trinitrate to nitric oxide in bovine aortic smooth muscle cells Biochemical Pharmacology. 47: 1737-1742. PMID 8204090 DOI: 10.1016/0006-2952(94)90300-X  0.522
1994 Salvemini D, Seibert K, Masferrer JL, Misko TP, Currie MG, Needleman P. Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. The Journal of Clinical Investigation. 93: 1940-7. PMID 7514189 DOI: 10.1172/Jci117185  0.337
1993 Salvemini D, Pistelli A, Vane J. Conversion of glyceryl trinitrate to nitric oxide in tolerant and non-tolerant smooth muscle and endothelial cells British Journal of Pharmacology. 108: 162-169. PMID 8381319 DOI: 10.1111/J.1476-5381.1993.Tb13457.X  0.542
1993 Salvemini D, Pistelli A, Mollace V. Release of nitric oxide from glyceryl trinitrate by captopril but not enalaprilat: In vitro and in vivo studies British Journal of Pharmacology. 109: 430-436. PMID 8358544 DOI: 10.1111/J.1476-5381.1993.Tb13587.X  0.347
1993 Salvemini D, Pistelli A, Anggard E. Vascular and anti-platelet actions of 1,2- and 1,3-glyceryl dinitrate British Journal of Pharmacology. 110: 937-942. PMID 8298817 DOI: 10.1111/J.1476-5381.1993.Tb13903.X  0.33
1993 Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P. Nitric oxide activates cyclooxygenase enzymes. Proceedings of the National Academy of Sciences of the United States of America. 90: 7240-4. PMID 7688473 DOI: 10.1073/Pnas.90.15.7240  0.345
1992 Salvemini D, Pistelli A, Mollace V, Änggård E, Vane J. The metabolism of glyceryl trinitrate to nitric oxide in the macrophage cell line J774 and its induction by Escherichia coli lipopolysaccharide Biochemical Pharmacology. 44: 17-24. PMID 1378739 DOI: 10.1016/0006-2952(92)90032-E  0.512
1992 Salvemini D, Mollace V, Pistelli A, Anggard E, Vane J. Cultured astrocytoma cells generate a nitric oxide-like factor from endogenous L-arginine and glyceryl trinitrate: Effect of E. coli lipopolysaccharide British Journal of Pharmacology. 106: 931-936. PMID 1327394 DOI: 10.1111/J.1476-5381.1992.Tb14437.X  0.503
1992 Gryglewski RJ, Zembowicz A, Salvemini D, Taylor GW, Vane JR. Modulation of the pharmacological actions of nitrovasodilators by methylene blue and pyocyanin British Journal of Pharmacology. 106: 838-845. PMID 1327388 DOI: 10.1111/J.1476-5381.1992.Tb14422.X  0.511
1992 Salvemini D, Mollace V, Pistelli A, Anggard E, Vane J. Metabolism of glyceryl trinitrate to nitric oxide by endothelial cells and smooth muscle cells and its induction by Escherichia coli lipopolysaccharide Proceedings of the National Academy of Sciences of the United States of America. 89: 982-986. PMID 1310543 DOI: 10.1073/Pnas.89.3.982  0.512
1992 Salvemini D, Pistelli A, Mollace V, Anggard E, Vane J. J774 Cells metabolise glyceryl trinitrate by an enzymic pathway which can be induced by E. colt lipopolysaccharide Pharmacological Research. 26: 229. DOI: 10.1016/1043-6618(92)91167-F  0.468
1991 Mollace V, Salvemini D, Vane J. Studies on the importance of the proposed release of nitric oxide from platelets Thrombosis Research. 65: 533-542. PMID 1725563 DOI: 10.1016/S0049-3848(05)80002-7  0.5
1991 Mollace V, Salvemini D, Anggard E, Vane J. Nitric oxide from vascular smooth muscle cells: Regulation of platelet reactivity and smooth muscle cell guanylate cyclase British Journal of Pharmacology. 104: 633-638. PMID 1724627 DOI: 10.1111/J.1476-5381.1991.Tb12481.X  0.522
1991 Masini E, Salvemini D, Pistelli A, Mannaioni PF, Vane JR. Rat mast cells synthesize a nitric oxide like-factor which modulates the release of histamine Agents and Actions. 33: 61-63. PMID 1716838 DOI: 10.1007/Bf01993127  0.529
1991 Salvemini D, Radziszewski W, Mollace V, Moore A, Willoughby D, Vane J. Diphenylene iodonium, an inhibitor of free radical formation, inhibits platelet aggregation European Journal of Pharmacology. 199: 15-18. PMID 1716574 DOI: 10.1016/0014-2999(91)90631-Y  0.489
1991 Masini E, Mannaioni PF, Pistelli A, Salvemini D, Vane J. Impairment of the L-arginine-nitric oxide pathway in mast cells from spontaneously hypertensive rats Biochemical and Biophysical Research Communications. 177: 1178-1182. PMID 1711845 DOI: 10.1016/0006-291X(91)90664-S  0.525
1991 Mannaioni PF, Masini E, Pistelli A, Salvemini D, Viale JR. Rat mast cells inhibit platelet aggregation by releasing a nitric oxide-like factor: Influence of histamine release Agents and Actions. 33: 423-428. PMID 1711277 DOI: 10.1007/978-3-0348-7309-3_33  0.32
1991 Salvemini D, De Nucci G, Vane JR. Superoxide dismutase cooperates with prostacyclin to inhibit platelet aggregation: a comparative study in washed platelets and platelet rich plasma Thrombosis and Haemostasis. 65: 421-424. PMID 1647553  0.413
1991 Salvemini D, Masini E, Pistelli A, Mannaioni PF, Vane J. Nitric Oxide: A Regulatory Mediator of Mast Cell Reactivity Journal of Cardiovascular Pharmacology. 17. DOI: 10.1097/00005344-199100001-00046  0.521
1991 Salvemini D, Masini E, Pistelli A, Mannaioni PF, Vane J. Nitric oxide: A regulatory mediator of mast cell reactivity Journal of Cardiovascular Pharmacology. 17.  0.482
1990 Mollace V, Salvemini D, Änggård E, Vane J. Cultured astrocytoma cells inhibit platelet aggregation by releasing a nitric oxide-like factor Biochemical and Biophysical Research Communications. 172: 564-569. PMID 2241954 DOI: 10.1016/0006-291X(90)90710-5  0.516
1990 Salvemini D, Korbut R, Änggård E, Vane J. Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide Proceedings of the National Academy of Sciences of the United States of America. 87: 2593-2597. PMID 2181441 DOI: 10.1073/Pnas.87.7.2593  0.523
1990 Salvemini D, Masini E, Anggard E, Mannaioni PF, Vane J. Synthesis of a nitric oxide-like factor from L-arginine by rat serosal mast cells: Stimulation of guanylate cyclase and inhibition of platelet aggregation Biochemical and Biophysical Research Communications. 169: 596-601. PMID 1972620 DOI: 10.1016/0006-291X(90)90372-T  0.526
1990 Salvemini D, Radziszewski W, Korbut R, Vane J. The use of oxyhaemoglobin to explore the events underlying inhibition of platelet aggregation induced by NO or NO-donors British Journal of Pharmacology. 101: 991-995. PMID 1707709 DOI: 10.1111/J.1476-5381.1990.Tb14194.X  0.505
1990 Mollace V, Salvemini D, Änggard E, Nisticò G, Vane J. Cultured astrocytoma cells release a nitric oxide-like factor Pharmacological Research. 22: 338. DOI: 10.1016/S1043-6618(09)80358-7  0.475
1990 Mannaioni PF, Masini E, Salvemini D, Pistelli A, Korbut R, Vane JR. Mast cell derived relaxing factor and the effect of nitric oxide generators on mast cell histamine release European Journal of Pharmacology. 183: 711. DOI: 10.1016/0014-2999(90)92505-D  0.489
1989 Salvemini D, De Nucci G, Sneddon JM, Vane JR. Superoxide anions enhance platelet adhesion and aggregation British Journal of Pharmacology. 97: 1145-1150. PMID 2551440 DOI: 10.1111/J.1476-5381.1989.Tb12572.X  0.477
1989 Salvemini D, De Nucci G, Gryglewski RJ, Vane JR. Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor Proceedings of the National Academy of Sciences of the United States of America. 86: 6328-6332. PMID 2548208 DOI: 10.1073/Pnas.86.16.6328  0.517
1989 Salvemini D, Korbut R, Änggård E, Vane JR. Lipopolysaccharide increases release of a nitric oxide-like factor from endothelial cells European Journal of Pharmacology. 171: 135-136. PMID 2515068 DOI: 10.1016/0014-2999(89)90437-8  0.448
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