Daniela Salvemini - Publications

Affiliations: 
Anatomy Saint Louis University, St. Louis, MO, United States 
Area:
Neuroscience Biology, Behavioral Sciences Psychology, Pharmacology

189 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Chen Z, Doyle TM, Luongo L, Largent-Milnes TM, Giancotti LA, Kolar G, Squillace S, Boccella S, Walker JK, Pendleton A, Spiegel S, Neumann WL, Vanderah TW, Salvemini D. Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America. PMID 31068460 DOI: 10.1073/pnas.1820466116  0.72
2019 Coppi E, Cherchi F, Fusco I, Failli P, Vona A, Dettori I, Gaviano L, Lucarini E, Jacobson KA, Tosh DK, Salvemini D, Ghelardini C, Pedata F, Di Cesare Mannelli L, Pugliese AM. Adenosine A3 receptor activation inhibits pronociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons. Pain. 160: 1103-1118. PMID 31008816 DOI: 10.1097/j.pain.0000000000001488  0.52
2019 Coppi E, Cherchi F, Fusco I, Failli P, Vona A, Dettori I, Gaviano L, Lucarini E, Jacobson KA, Tosh DK, Salvemini D, Ghelardini C, Pedata F, Di Cesare Mannelli L, Pugliese AM. Title: Adenosine A3 receptor activation inhibits pro-nociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons. Pain. PMID 30938716 DOI: 10.1097/j.pain.0000000000001488  0.52
2018 Stockstill K, Doyle TM, Yan X, Chen Z, Janes K, Little JW, Braden K, Lauro F, Giancotti LA, Harada CM, Yadav R, Xiao WH, Lionberger JM, Neumann WL, Bennett GJ, ... ... Salvemini D, et al. Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain. The Journal of Experimental Medicine. PMID 29703731 DOI: 10.1084/jem.20170584  0.72
2018 Touchette JC, Little JW, Wilken GH, Salvemini D, Macarthur H. The neurotoxin DSP-4 induces hyperalgesia in rats that is accompanied by spinal oxidative stress and cytokine production. Neuroscience. PMID 29421433 DOI: 10.1016/j.neuroscience.2018.01.058  0.52
2018 Wahlman C, Doyle TM, Little JW, Luongo L, Janes K, Chen Z, Esposito E, Tosh DK, Cuzzocrea S, Jacobson KA, Salvemini D. Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels via astrocyte-dependent mechanisms. Pain. PMID 29419652 DOI: 10.1097/j.pain.0000000000001177  0.72
2018 Cuzzocrea S, Doyle T, Campolo M, Paterniti I, Esposito E, Farr S, Salvemini D. Sphingosine 1-phosphate receptor subtype 1 (S1PR1) as a therapeutic target for brain trauma. Journal of Neurotrauma. PMID 29310513 DOI: 10.1089/neu.2017.5391  0.52
2017 Salvemini D, Jacobson KA. Highly selective A3 adenosine receptor agonists relieve chronic neuropathic pain. Expert Opinion On Therapeutic Patents. PMID 28604241 DOI: 10.1080/13543776.2017.1341018  0.52
2017 Petrelli R, Scortichini M, Kachler S, Boccella S, Cerchia C, Torquati I, Del Bello F, Salvemini D, Novellino E, Luongo L, Maione S, Jacobson KA, Lavecchia A, Klotz KN, Cappellacci L. Exploring the role of N(6)-substituents in potent dual acting 5'-C-ethyl-tetrazolyl-adenosine derivatives: synthesis, binding, functional assays and antinociceptive effects in mice. Journal of Medicinal Chemistry. PMID 28447789 DOI: 10.1021/acs.jmedchem.7b00291  0.52
2017 Tosh DK, Janowsky A, Eshleman AJ, Warnick E, Gao ZG, Chen Z, Gizewski E, Auchampach JA, Salvemini D, Jacobson KA. Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters. Journal of Medicinal Chemistry. PMID 28319392 DOI: 10.1021/acs.jmedchem.7b00141  0.52
2016 Slosky LM, BassiriRad NM, Symons AM, Thompson M, Doyle T, Forte BL, Staatz WD, Bui L, Neumann WL, Mantyh PW, Salvemini D, Largent-Milnes TM, Vanderah TW. The Cystine/Glutamate Antiporter System xc- Drives Breast Tumor Cell Glutamate Release and Cancer-Induced Bone Pain. Pain. PMID 27482630 DOI: 10.1097/j.pain.0000000000000681  0.72
2016 Malafoglia V, Traversetti L, Del Grosso F, Scalici M, Lauro F, Russo V, Persichini T, Salvemini D, Mollace V, Fini M, Raffaeli W, Muscoli C, Colasanti M. Transient Receptor Potential Melastatin-3 (TRPM3) Mediates Nociceptive-Like Responses in Hydra vulgaris. Plos One. 11: e0151386. PMID 26974325 DOI: 10.1371/journal.pone.0151386  0.72
2016 Tosh DK, Ciancetta A, Warnick E, O'Connor R, Chen Z, Gizewski E, Crane S, Gao ZG, Auchampach JA, Salvemini D, Jacobson KA. Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists. Journal of Medicinal Chemistry. PMID 26890707 DOI: 10.1021/acs.jmedchem.5b01998  0.72
2016 Janes K, Symons-Liguori AM, Jacobson KA, Salvemini D. Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics. British Journal of Pharmacology. PMID 26804983 DOI: 10.1111/bph.13446  0.72
2015 Carlin JL, Tosh DK, Xiao C, Pinol RA, Chen Z, Salvemini D, Gavrilova O, Jacobson KA, Reitman ML. Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice that is Dependent on Central Histamine H1 Receptors. The Journal of Pharmacology and Experimental Therapeutics. PMID 26606937 DOI: 10.1124/jpet.115.229872  0.72
2015 Trang T, Al-Hasani R, Salvemini D, Salter MW, Gutstein H, Cahill CM. Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13879-88. PMID 26468188 DOI: 10.1523/JNEUROSCI.2711-15.2015  0.72
2015 Tosh DK, Paoletta S, Chen Z, Crane S, Lloyd J, Gao ZG, Gizewski ET, Auchampach JA, Salvemini D, Jacobson KA. Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists. Medchemcomm. 6: 555-563. PMID 26236460 DOI: 10.1039/C4MD00571F  0.52
2015 Tosh DK, Crane S, Chen Z, Paoletta S, Gao ZG, Gizewski E, Auchampach JA, Salvemini D, Jacobson KA. Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy. Acs Medicinal Chemistry Letters. 6: 804-8. PMID 26191370 DOI: 10.1021/acsmedchemlett.5b00150  0.72
2015 Tosh DK, Padia J, Salvemini D, Jacobson KA. Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signalling. PMID 26111639 DOI: 10.1007/s11302-015-9459-2  0.52
2015 Luongo L, Malcangio M, Salvemini D, Starowicz K. Chronic pain: new insights in molecular and cellular mechanisms. Biomed Research International. 2015: 676725. PMID 25879035 DOI: 10.1155/2015/676725  0.72
2015 Ford A, Castonguay A, Cottet M, Little JW, Chen Z, Symons-Liguori AM, Doyle T, Egan TM, Vanderah TW, De Konnick Y, Tosh DK, Jacobson KA, Salvemini D. Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6057-67. PMID 25878279 DOI: 10.1523/JNEUROSCI.4495-14.2015  0.72
2015 Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S, Bannister K, Dickenson AH, Vanderah TW, Porreca F, Jacobson KA, ... Salvemini D, et al. Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain : a Journal of Neurology. 138: 28-35. PMID 25414036 DOI: 10.1093/brain/awu330  0.72
2015 Janes K, Wahlman C, Little JW, Doyle T, Tosh DK, Jacobson KA, Salvemini D. Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy. Brain, Behavior, and Immunity. 44: 91-9. PMID 25220279 DOI: 10.1016/j.bbi.2014.08.010  0.72
2015 Tosh DK, Paoletta S, Chen Z, Crane S, Lloyd J, Gao ZG, Gizewski ET, Auchampach JA, Salvemini D, Jacobson KA. Structure-based design, synthesis by click chemistry and in vivo activity of highly selective A3 adenosine receptor agonists Medchemcomm. 6: 555-563. DOI: 10.1039/c4md00571f  0.72
2015 Lauro F, Ilari S, Giancotti LA, Morabito C, Malafoglia V, Gliozzi M, Palma E, Salvemini D, Muscoli C. The protective role of bergamot polyphenolic fraction on several animal models of pain Pharmanutrition. DOI: 10.1016/j.phanu.2016.04.001  0.72
2015 Tosh DK, Padia J, Salvemini D, Jacobson KA. Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain Purinergic Signalling. DOI: 10.1007/s11302-015-9459-2  0.72
2014 Tosh DK, Finley A, Paoletta S, Moss SM, Gao ZG, Gizewski ET, Auchampach JA, Salvemini D, Jacobson KA. In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists. Journal of Medicinal Chemistry. 57: 9901-14. PMID 25422861 DOI: 10.1021/jm501021n  0.72
2014 Janes K, Esposito E, Doyle T, Cuzzocrea S, Tosh DK, Jacobson KA, Salvemini D. A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways. Pain. 155: 2560-7. PMID 25242567 DOI: 10.1016/j.pain.2014.09.016  0.72
2014 Mollace V, Muscoli C, Dagostino C, Giancotti LA, Gliozzi M, Sacco I, Visalli V, Gratteri S, Palma E, Malara N, Musolino V, Carresi C, Muscoli S, Vitale C, Salvemini D, et al. The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance. Pharmacological Research. 89: 29-35. PMID 25174989 DOI: 10.1016/j.phrs.2014.07.007  0.72
2014 Tosh DK, Paoletta S, Chen Z, Moss SM, Gao ZG, Salvemini D, Jacobson KA. Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor. Bioorganic & Medicinal Chemistry Letters. 24: 3302-6. PMID 24969016 DOI: 10.1016/j.bmcl.2014.06.006  0.72
2014 Janes K, Little JW, Li C, Bryant L, Chen C, Chen Z, Kamocki K, Doyle T, Snider A, Esposito E, Cuzzocrea S, Bieberich E, Obeid L, Petrache I, Nicol G, ... ... Salvemini D, et al. The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. The Journal of Biological Chemistry. 289: 21082-97. PMID 24876379 DOI: 10.1074/jbc.M114.569574  0.72
2014 Rajagopalan P, Tracey H, Chen Z, Bandyopadhyaya A, Veeraraghavan S, Rajagopalan DR, Salvemini D, McPhee I, Viswanadha S, Rajagopalan R. DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain. Bioorganic & Medicinal Chemistry Letters. 24: 3088-91. PMID 24863744 DOI: 10.1016/j.bmcl.2014.05.016  0.72
2014 Paoletta S, Tosh DK, Salvemini D, Jacobson KA. Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners. Plos One. 9: e97858. PMID 24859150 DOI: 10.1371/journal.pone.0097858  0.72
2014 Bennett GJ, Doyle T, Salvemini D. Mitotoxicity in distal symmetrical sensory peripheral neuropathies. Nature Reviews. Neurology. 10: 326-36. PMID 24840972 DOI: 10.1038/nrneurol.2014.77  0.72
2013 Janes K, Doyle T, Bryant L, Esposito E, Cuzzocrea S, Ryerse J, Bennett GJ, Salvemini D. Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase. Pain. 154: 2432-40. PMID 23891899 DOI: 10.1016/j.pain.2013.07.032  0.72
2013 Muscoli C, Dagostino C, Ilari S, Lauro F, Gliozzi M, Bardhi E, Palma E, Mollace V, Salvemini D. Posttranslational nitration of tyrosine residues modulates glutamate transmission and contributes to N-methyl-D-aspartate-mediated thermal hyperalgesia. Mediators of Inflammation. 2013: 950947. PMID 23864769 DOI: 10.1155/2013/950947  0.72
2013 Paoletta S, Tosh DK, Finley A, Gizewski ET, Moss SM, Gao ZG, Auchampach JA, Salvemini D, Jacobson KA. Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain. Journal of Medicinal Chemistry. 56: 5949-63. PMID 23789857 DOI: 10.1021/jm4007966  0.72
2013 Little JW, Cuzzocrea S, Bryant L, Esposito E, Doyle T, Rausaria S, Neumann WL, Salvemini D. Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance. Pain. 154: 978-86. PMID 23590939 DOI: 10.1016/j.pain.2013.02.018  0.72
2013 Doyle T, Esposito E, Bryant L, Cuzzocrea S, Salvemini D. NADPH-oxidase 2 activation promotes opioid-induced antinociceptive tolerance in mice. Neuroscience. 241: 1-9. PMID 23454539 DOI: 10.1016/j.neuroscience.2013.02.042  0.72
2013 Salvemini D, Kim SF, Mollace V. Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 304: R473-87. PMID 23389111 DOI: 10.1152/ajpregu.00355.2012  0.72
2013 Finley A, Chen Z, Esposito E, Cuzzocrea S, Sabbadini R, Salvemini D. Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism. Plos One. 8: e55255. PMID 23372844 DOI: 10.1371/journal.pone.0055255  0.72
2013 Salvemini D, Doyle T, Kress M, Nicol G. Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain. Trends in Pharmacological Sciences. 34: 110-8. PMID 23318139 DOI: 10.1016/j.tips.2012.12.001  0.72
2012 Little JW, Chen Z, Doyle T, Porreca F, Ghaffari M, Bryant L, Neumann WL, Salvemini D. Supraspinal peroxynitrite modulates pain signaling by suppressing the endogenous opioid pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10797-808. PMID 22875915 DOI: 10.1523/JNEUROSCI.6345-11.2012  0.72
2012 Doyle T, Chen Z, Muscoli C, Bryant L, Esposito E, Cuzzocrea S, Dagostino C, Ryerse J, Rausaria S, Kamadulski A, Neumann WL, Salvemini D. Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 6149-60. PMID 22553021 DOI: 10.1523/JNEUROSCI.6343-11.2012  0.72
2012 Chen Z, Janes K, Chen C, Doyle T, Bryant L, Tosh DK, Jacobson KA, Salvemini D. Controlling murine and rat chronic pain through A3 adenosine receptor activation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1855-65. PMID 22345405 DOI: 10.1096/fj.11-201541  0.72
2012 Janes K, Neumann WL, Salvemini D. Anti-superoxide and anti-peroxynitrite strategies in pain suppression. Biochimica Et Biophysica Acta. 1822: 815-21. PMID 22200449 DOI: 10.1016/j.bbadis.2011.12.008  0.72
2012 Miriyala S, Spasojevic I, Tovmasyan A, Salvemini D, Vujaskovic Z, St Clair D, Batinic-Haberle I. Manganese superoxide dismutase, MnSOD and its mimics. Biochimica Et Biophysica Acta. 1822: 794-814. PMID 22198225 DOI: 10.1016/j.bbadis.2011.12.002  0.72
2012 Little JW, Doyle T, Salvemini D. Reactive nitroxidative species and nociceptive processing: determining the roles for nitric oxide, superoxide, and peroxynitrite in pain. Amino Acids. 42: 75-94. PMID 20552384 DOI: 10.1007/s00726-010-0633-0  0.72
2011 Rausaria S, Ghaffari MM, Kamadulski A, Rodgers K, Bryant L, Chen Z, Doyle T, Shaw MJ, Salvemini D, Neumann WL. Retooling manganese(III) porphyrin-based peroxynitrite decomposition catalysts for selectivity and oral activity: a potential new strategy for treating chronic pain. Journal of Medicinal Chemistry. 54: 8658-69. PMID 22082008 DOI: 10.1021/jm201233r  0.72
2011 Doyle T, Chen Z, Obeid LM, Salvemini D. Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia. Neuroscience Letters. 499: 4-8. PMID 21605625 DOI: 10.1016/j.neulet.2011.05.018  0.72
2011 Samlowski WE, Kondapaneni M, Tharkar S, McGregor JR, Laubach VE, Salvemini D. Endothelial nitric oxide synthase is a key mediator of interleukin-2-induced hypotension and vascular leak syndrome. Journal of Immunotherapy (Hagerstown, Md. : 1997). 34: 419-27. PMID 21577143 DOI: 10.1097/CJI.0b013e31821dcb50  0.72
2011 Doyle T, Chen Z, Muscoli C, Obeid LM, Salvemini D. Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2782-91. PMID 21551240 DOI: 10.1096/fj.10-178095  0.72
2011 Tovmasyan AG, Rajic Z, Spasojevic I, Reboucas JS, Chen X, Salvemini D, Sheng H, Warner DS, Benov L, Batinic-Haberle I. Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins. Dalton Transactions (Cambridge, England : 2003). 40: 4111-21. PMID 21384047 DOI: 10.1039/c0dt01321h  0.72
2011 Rausaria S, Kamadulski A, Rath NP, Bryant L, Chen Z, Salvemini D, Neumann WL. Manganese(III) complexes of bis(hydroxyphenyl)dipyrromethenes are potent orally active peroxynitrite scavengers. Journal of the American Chemical Society. 133: 4200-3. PMID 21370860 DOI: 10.1021/ja110427e  0.72
2011 Salvemini D, Little JW, Doyle T, Neumann WL. Roles of reactive oxygen and nitrogen species in pain. Free Radical Biology & Medicine. 51: 951-66. PMID 21277369 DOI: 10.1016/j.freeradbiomed.2011.01.026  0.72
2011 Doyle T, Finley A, Chen Z, Salvemini D. Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats. Pain. 152: 643-8. PMID 21239112 DOI: 10.1016/j.pain.2010.12.011  0.72
2010 Muscoli C, Doyle T, Dagostino C, Bryant L, Chen Z, Watkins LR, Ryerse J, Bieberich E, Neumman W, Salvemini D. Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15400-8. PMID 21084596 DOI: 10.1523/JNEUROSCI.2391-10.2010  0.72
2010 Salvemini D. Searching for new strategies for the pharmacological treatment of chronic pain. Missouri Medicine. 107: 262-4. PMID 20806838  0.72
2010 Doyle T, Bryant L, Muscoli C, Cuzzocrea S, Esposito E, Chen Z, Salvemini D. Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance. Neuroscience Letters. 483: 85-9. PMID 20637262 DOI: 10.1016/j.neulet.2010.07.013  0.72
2010 Chen Z, Muscoli C, Doyle T, Bryant L, Cuzzocrea S, Mollace V, Mastroianni R, Masini E, Salvemini D. NMDA-receptor activation and nitroxidative regulation of the glutamatergic pathway during nociceptive processing. Pain. 149: 100-6. PMID 20167432 DOI: 10.1016/j.pain.2010.01.015  0.72
2010 Salvemini D, Neumann W. Targeting peroxynitrite driven nitroxidative stress with synzymes: A novel therapeutic approach in chronic pain management. Life Sciences. 86: 604-14. PMID 19576230 DOI: 10.1016/j.lfs.2009.06.011  0.72
2009 Bryant L, Doyle T, Chen Z, Cuzzocrea S, Masini E, Vinci MC, Esposito E, Mazzon E, Petrusca DN, Petrache I, Salvemini D. Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance. Neuroscience Letters. 463: 49-53. PMID 19631718 DOI: 10.1016/j.neulet.2009.07.051  0.72
2009 Doyle T, Bryant L, Batinic-Haberle I, Little J, Cuzzocrea S, Masini E, Spasojevic I, Salvemini D. Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance Neuroscience. 164: 702-710. PMID 19607887 DOI: 10.1016/j.neuroscience.2009.07.019  0.72
2009 Kos I, Rebouças JS, DeFreitas-Silva G, Salvemini D, Vujaskovic Z, Dewhirst MW, Spasojević I, Batinić-Haberle I. Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins. Free Radical Biology & Medicine. 47: 72-8. PMID 19361553 DOI: 10.1016/j.freeradbiomed.2009.04.002  0.72
2009 Masini E, Ragazzo E, Vinci MC, Nistri S, Cinci L, Mastroianni R, Thurmond RL, Salvemini D. A selective H4R antagonist prevents antigen-induced asthma-like reaction and airway inflammation in guinea pigs Inflammation Research. 58. PMID 19274434 DOI: 10.1007/s00011-009-0643-0  0.72
2009 Salvemini D, Neumann WL. Peroxynitrite: a strategic linchpin of opioid analgesic tolerance. Trends in Pharmacological Sciences. 30: 194-202. PMID 19261337 DOI: 10.1016/j.tips.2008.12.005  0.72
2009 Ndengele MM, Cuzzocrea S, Masini E, Vinci MC, Esposito E, Muscoli C, Petrusca DN, Mollace V, Mazzon E, Li D, Petrache I, Matuschak GM, Salvemini D. Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation. The Journal of Pharmacology and Experimental Therapeutics. 329: 64-75. PMID 19033555 DOI: 10.1124/jpet.108.146290  0.72
2009 Salvemini D. Peroxynitrite and opiate antinociceptive tolerance: a painful reality. Archives of Biochemistry and Biophysics. 484: 238-44. PMID 19017525 DOI: 10.1016/j.abb.2008.11.005  0.72
2009 Batinić-Haberle I, Cuzzocrea S, Rebouças JS, Ferrer-Sueta G, Mazzon E, Di Paola R, Radi R, Spasojević I, Benov L, Salvemini D. Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy. Free Radical Biology & Medicine. 46: 192-201. PMID 19007878 DOI: 10.1016/j.freeradbiomed.2008.09.042  0.72
2009 Batinić-Haberle I, Ndengele MM, Cuzzocrea S, Rebouças JS, Spasojević I, Salvemini D. Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways. Free Radical Biology & Medicine. 46: 212-9. PMID 18983908 DOI: 10.1016/j.freeradbiomed.2008.09.037  0.72
2009 Cuzzocrea S, Deigner HP, Genovese T, Mazzon E, Esposito E, Crisafulli C, Di Paola R, Bramanti P, Matuschak G, Salvemini D. Inhibition of ceramide biosynthesis ameliorates pathological consequences of spinal cord injury. Shock (Augusta, Ga.). 31: 634-44. PMID 18838947 DOI: 10.1097/SHK.0b013e3181891396  0.72
2009 Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Crisafulli C, Di Paola R, Bramanti P, Salvemini D. Fumonisin b1 reduces the development of multiple organ failure induced by zymosan in mice. Shock (Augusta, Ga.). 31: 170-7. PMID 18650782 DOI: 10.1097/SHK.0b013e31817fbd4a  0.72
2008 Cuzzocrea S, Di Paola R, Genovese T, Mazzon E, Esposito E, Crisafulli C, Bramanti P, Salvemini D. Anti-inflammatory and anti-apoptotic effects of fumonisin B1, an inhibitor of ceramide synthase, in a rodent model of splanchnic ischemia and reperfusion injury. The Journal of Pharmacology and Experimental Therapeutics. 327: 45-57. PMID 18612046 DOI: 10.1124/jpet.108.139808  0.72
2008 Ndengele MM, Cuzzocrea S, Esposito E, Mazzon E, Di Paola R, Matuschak GM, Salvemini D. Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3154-64. PMID 18497304 DOI: 10.1096/fj.08-108159  0.72
2008 Kondapaneni M, McGregor JR, Salvemini D, Laubach VE, Samlowski WE. Inducible nitric oxide synthase (iNOS) is not required for IL-2-induced hypotension and vascular leak syndrome in mice. Journal of Immunotherapy (Hagerstown, Md. : 1997). 31: 325-33. PMID 18391763 DOI: 10.1097/CJI.0b013e31816112e8  0.72
2008 Masini E, Giannini L, Nistri S, Cinci L, Mastroianni R, Xu W, Comhair SA, Li D, Cuzzocrea S, Matuschak GM, Salvemini D. Ceramide: a key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation. The Journal of Pharmacology and Experimental Therapeutics. 324: 548-57. PMID 18042827 DOI: 10.1124/jpet.107.131565  0.72
2007 Muscoli C, Cuzzocrea S, Ndengele MM, Mollace V, Porreca F, Fabrizi F, Esposito E, Masini E, Matuschak GM, Salvemini D. Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice. The Journal of Clinical Investigation. 117: 3530-9. PMID 17975673 DOI: 10.1172/JCI32420  0.72
2007 Cuzzocrea S, Salvemini D. Molecular mechanisms involved in the reciprocal regulation of cyclooxygenase and nitric oxide synthase enzymes Kidney International. 71: 290-297. PMID 17200681 DOI: 10.1038/sj.ki.5002058  0.72
2006 Salvemini D, Doyle TM, Cuzzocrea S. Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation Biochemical Society Transactions. 34: 965-970. PMID 17052238 DOI: 10.1042/BST0340965  0.72
2006 Cuzzocrea S, Mazzon E, Di Paola R, Esposito E, Macarthur H, Matuschak GM, Salvemini D. A role for nitric oxide-mediated peroxynitrite formation in a model of endotoxin-induced shock. The Journal of Pharmacology and Experimental Therapeutics. 319: 73-81. PMID 16815867 DOI: 10.1124/jpet.106.108100  0.72
2005 Fike CD, Aschner JL, Zhang Y, Salvemini D, Kaplowitz MR. Superoxide and chronic hypoxia-induced pulmonary hypertension in newborn piglets. Chest. 128: 555S-556S. PMID 16373823 DOI: 10.1378/chest.128.6_suppl.555S  0.72
2005 Cuzzocrea S, Mazzon E, di Paola R, Genovese T, Muià C, Caputi AP, Salvemini D. Synergistic interaction between methotrexate and a superoxide dismutase mimetic: pharmacologic and potential clinical significance. Arthritis and Rheumatism. 52: 3755-60. PMID 16320326 DOI: 10.1002/art.21480  0.72
2005 Masini E, Bani D, Vannacci A, Pierpaoli S, Mannaioni PF, Comhair SA, Xu W, Muscoli C, Erzurum SC, Salvemini D. Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic. Free Radical Biology & Medicine. 39: 520-31. PMID 16043023 DOI: 10.1016/j.freeradbiomed.2005.04.006  0.72
2005 Cuzzocrea S, Mazzon E, Paola RD, Genovese T, Muià C, Caputi AP, Salvemini D. Effects of combination M40403 and dexamethasone therapy on joint disease in a rat model of collagen-induced arthritis. Arthritis and Rheumatism. 52: 1929-40. PMID 15934059 DOI: 10.1002/art.21044  0.72
2005 Mollace V, Muscoli C, Masini E, Cuzzocrea S, Salvemini D. Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors. Pharmacological Reviews. 57: 217-52. PMID 15914468 DOI: 10.1124/pr.57.2.1  0.72
2005 Ndengele MM, Muscoli C, Wang ZQ, Doyle TM, Matuschak GM, Salvemini D. Superoxide potentiates NF-kappaB activation and modulates endotoxin-induced cytokine production in alveolar macrophages. Shock (Augusta, Ga.). 23: 186-93. PMID 15665736 DOI: 10.1097/01.shk.0000144130.36771.d6  0.72
2005 Chen Y, Hou M, Li Y, Traverse JH, Zhang P, Salvemini D, Fukai T, Bache RJ. Increased superoxide production causes coronary endothelial dysfunction and depressed oxygen consumption in the failing heart. American Journal of Physiology. Heart and Circulatory Physiology. 288: H133-41. PMID 15598865 DOI: 10.1152/ajpheart.00851.2003  0.72
2004 Nicotera TM, Ding D, McFadden SL, Salvemini D, Salvi R. Paraquat-induced hair cell damage and protection with the superoxide dismutase mimetic m40403. Audiology & Neuro-Otology. 9: 353-62. PMID 15467288 DOI: 10.1159/000081284  0.72
2004 Muscoli C, Mollace V, Wheatley J, Masini E, Ndengele M, Wang ZQ, Salvemini D. Superoxide-mediated nitration of spinal manganese superoxide dismutase: a novel pathway in N-methyl-D-aspartate-mediated hyperalgesia. Pain. 111: 96-103. PMID 15327813 DOI: 10.1016/j.pain.2004.06.004  0.72
2004 Cuzzocrea S, Genovese T, Mazzon E, Di Paola R, Muià C, Britti D, Salvemini D. Reduction in the development of cerulein-induced acute pancreatitis by treatment with M40401, a new selective superoxide dismutase mimetic. Shock (Augusta, Ga.). 22: 254-61. PMID 15316396 DOI: 10.1097/01.shk.0000132490.79498.11  0.72
2004 Cuzzocrea S, Pisano B, Dugo L, Ianaro A, Ndengele M, Salvemini D. Superoxide-related signaling cascade mediates nuclear factor-kappaB activation in acute inflammation. Antioxidants & Redox Signaling. 6: 699-704. PMID 15242550 DOI: 10.1089/1523086041361659  0.72
2004 Muscoli C, Sacco I, Alecce W, Palma E, Nisticò R, Costa N, Clementi F, Rotiroti D, Romeo F, Salvemini D, Mehta JL, Mollace V. The protective effect of superoxide dismutase mimetic M40401 on balloon injury-related neointima formation: role of the lectin-like oxidized low-density lipoprotein receptor-1. The Journal of Pharmacology and Experimental Therapeutics. 311: 44-50. PMID 15220383 DOI: 10.1124/jpet.104.068205  0.72
2004 Cui X, Parent C, Macarthur H, Ochs SD, Gerstenberg E, Solomon S, Fitz Y, Danner RL, Banks SM, Natanson C, Salvemini D, Eichacker PQ. Severity of sepsis alters the effects of superoxide anion inhibition in a rat sepsis model. Journal of Applied Physiology (Bethesda, Md. : 1985). 97: 1349-57. PMID 15169752 DOI: 10.1152/japplphysiol.01161.2003  0.72
2004 Cuzzocrea S, Thiemermann C, Salvemini D. Potential therapeutic effect of antioxidant therapy in shock and inflammation. Current Medicinal Chemistry. 11: 1147-62. PMID 15134512  0.72
2004 Wang ZQ, Porreca F, Cuzzocrea S, Galen K, Lightfoot R, Masini E, Muscoli C, Mollace V, Ndengele M, Ischiropoulos H, Salvemini D. A newly identified role for superoxide in inflammatory pain. The Journal of Pharmacology and Experimental Therapeutics. 309: 869-78. PMID 14988418 DOI: 10.1124/jpet.103.064154  0.72
2004 Cuzzocrea S, Mazzon E, Dugo L, Di Paola R, Caputi AP, Salvemini D. Superoxide: A key player in hypertension Faseb Journal. 18: 94-101. PMID 14718390 DOI: 10.1096/fj.03-0428com  0.72
2004 Cuzzocrea S, Mazzon E, Di Paola R, Genovese T, Serraino I, Dugo L, Cuzzocrea E, Fulia F, Caputi AP, Salvemini D. Protective effects of M40401, a selective superoxide dismutase mimetic, on zymosan-induced nonseptic shock. Critical Care Medicine. 32: 157-67. PMID 14707575 DOI: 10.1097/01.CCM.0000098859.67006.45  0.72
2003 Muscoli C, Cuzzocrea S, Riley DP, Zweier JL, Thiemermann C, Wang ZQ, Salvemini D. On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies. British Journal of Pharmacology. 140: 445-60. PMID 14522841 DOI: 10.1038/sj.bjp.0705430  0.72
2003 Salvemini D, Samlowski WE. Role of manganese superoxide dismutase in cancer [1] (multiple letters) Nature Medicine. 9: 1103. PMID 12949512  0.72
2003 Jiang F, Guo Y, Salvemini D, Dusting GJ. Superoxide dismutase mimetic M40403 improves endothelial function in apolipoprotein(E)-deficient mice. British Journal of Pharmacology. 139: 1127-34. PMID 12871831 DOI: 10.1038/sj.bjp.0705354  0.72
2003 Mollace V, Iannone M, Muscoli C, Palma E, Granato T, Modesti A, Nisticò R, Rotiroti D, Salvemini D. The protective effect of M40401, a superoxide dismutase mimetic, on post-ischemic brain damage in Mongolian gerbils. Bmc Pharmacology. 3: 8. PMID 12809567 DOI: 10.1186/1471-2210-3-8  0.72
2003 Salvemini D, Ischiropoulos H, Cuzzocrea S. Roles of nitric oxide and superoxide in inflammation. Methods in Molecular Biology (Clifton, N.J.). 225: 291-303. PMID 12769497 DOI: 10.1385/1-59259-374-7:291  0.72
2003 Marzocca C, Vannacci A, Cuzzocrea S, Salvemini D, Mannaioni PF, Masini E. Effects of the SOD mimetic, M40403, on prostaglandin production in an in vivo model of ischemia and reperfusion in rat heart Inflammation Research. 52. PMID 12755394 DOI: 10.1007/s000110300037  0.72
2003 Samlowski WE, Petersen R, Cuzzocrea S, Macarthur H, Burton D, McGregor JR, Salvemini D. A nonpeptidyl mimic of superoxide dismutase, M40403, inhibits dose-limiting hypotension associated with interleukin-2 and increases its antitumor effects. Nature Medicine. 9: 750-5. PMID 12730689 DOI: 10.1038/nm874  0.72
2003 Fries DM, Paxinou E, Themistocleous M, Swanberg E, Griendling KK, Salvemini D, Slot JW, Heijnen HF, Hazen SL, Ischiropoulos H. Expression of inducible nitric-oxide synthase and intracellular protein tyrosine nitration in vascular smooth muscle cells: role of reactive oxygen species. The Journal of Biological Chemistry. 278: 22901-7. PMID 12690103 DOI: 10.1074/jbc.M210806200  0.72
2003 Tuder RM, Zhen L, Cho CY, Taraseviciene-Stewart L, Kasahara Y, Salvemini D, Voelkel NF, Flores SC. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. American Journal of Respiratory Cell and Molecular Biology. 29: 88-97. PMID 12600822 DOI: 10.1165/rcmb.2002-0228OC  0.72
2003 McFadden SL, Ding D, Salvemini D, Salvi RJ. M40403, a superoxide dismutase mimetic, protects cochlear hair cells from gentamicin, but not cisplatin toxicity. Toxicology and Applied Pharmacology. 186: 46-54. PMID 12583992 DOI: 10.1016/S0041-008X(02)00017-0  0.72
2003 Macarthur H, Couri DM, Wilken GH, Westfall TC, Lechner AJ, Matuschak GM, Chen Z, Salvemini D. Modulation of serum cytokine levels by a novel superoxide dismutase mimetic, M40401, in an Escherichia coli model of septic shock: correlation with preserved circulating catecholamines. Critical Care Medicine. 31: 237-45. PMID 12545022 DOI: 10.1097/01.CCM.0000045202.66538.DB  0.72
2003 Salvemini D, Cuzzocrea S. Therapeutic potential of superoxide dismutase mimetics as therapeutic agents in critical care medicine. Critical Care Medicine. 31: S29-38. PMID 12544974 DOI: 10.1097/01.CCM.0000042468.64712.21  0.72
2003 Mollace V, Iannone M, Muscoli C, Palma E, Granato T, Rispoli V, Nisticò R, Rotiroti D, Salvemini D. The role of oxidative stress in paraquat-induced neurotoxicity in rats: protection by non peptidyl superoxide dismutase mimetic. Neuroscience Letters. 335: 163-6. PMID 12531458 DOI: 10.1016/S0304-3940(02)01168-0  0.72
2003 Wang C, McInnis J, West JB, Bao J, Anastasio N, Guidry JA, Ye Y, Salvemini D, Johnson KM. Blockade of phencyclidine-induced cortical apoptosis and deficits in prepulse inhibition by M40403, a superoxide dismutase mimetic. The Journal of Pharmacology and Experimental Therapeutics. 304: 266-71. PMID 12490600 DOI: 10.1124/jpet.102.041798  0.72
2002 Salvemini D, Muscoli C, Riley DP, Cuzzocrea S. Superoxide dismutase mimetics. Pulmonary Pharmacology & Therapeutics. 15: 439-47. PMID 12406666 DOI: 10.1006/pupt.2002.0374  0.72
2002 Salvemini D, Cuzzocrea S. Oxidative stress in septic shock and disseminated intravascular coagulation. Free Radical Biology & Medicine. 33: 1173-85. PMID 12398925 DOI: 10.1016/S0891-5849(02)00961-9  0.72
2002 Muscoli C, Salvemini D, Paolino D, Iannone M, Palma E, Cufari A, Rotiroti D, Perno CF, Aquaro S, Mollace V. Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages. Bmc Neuroscience. 3: 13. PMID 12234380 DOI: 10.1186/1471-2202-3-13  0.72
2002 Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Di Paola R, Britti D, De Sarro A, Pierpaoli S, Caputi A, Masini E, Salvemini D. A role for superoxide in gentamicin-mediated nephropathy in rats. European Journal of Pharmacology. 450: 67-76. PMID 12176111 DOI: 10.1016/S0014-2999(02)01749-1  0.72
2002 Salvemini D, Cuzzocrea S. Superoxide, superoxide dismutase and ischemic injury. Current Opinion in Investigational Drugs (London, England : 2000). 3: 886-95. PMID 12137408  0.72
2002 Salvemini D, Riley DP, Cuzzocrea S. SOD mimetics are coming of age. Nature Reviews. Drug Discovery. 1: 367-74. PMID 12120412 DOI: 10.1038/nrd796  0.72
2002 Masini E, Cuzzocrea S, Mazzon E, Marzocca C, Mannaioni PF, Salvemini D. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. British Journal of Pharmacology. 136: 905-17. PMID 12110615 DOI: 10.1038/sj.bjp.0704774  0.72
2002 McInnis J, Wang C, Anastasio N, Hultman M, Ye Y, Salvemini D, Johnson KM. The role of superoxide and nuclear factor-kappaB signaling in N-methyl-D-aspartate-induced necrosis and apoptosis. The Journal of Pharmacology and Experimental Therapeutics. 301: 478-87. PMID 11961046 DOI: 10.1124/jpet.301.2.478  0.72
2002 Mollace V, Muscoli C, Iannone M, Palma E, Rotiroti D, Romeo F, Nisticò R, Salvemini D. Dexamethasone inhibits the inducible bioconversion of glyceryl trinitrate to nitric oxide. Journal of Cardiovascular Pharmacology. 39: 544-51. PMID 11904528 DOI: 10.1097/00005344-200204000-00010  0.72
2002 Mollace V, Salvemini D, Riley DP, Muscoli C, Iannone M, Granato T, Masuelli L, Modesti A, Rotiroti D, Nisticó R, Bertoli A, Perno CF, Aquaro S. The contribution of oxidative stress in apoptosis of human-cultured astroglial cells induced by supernatants of HIV-1-infected macrophages. Journal of Leukocyte Biology. 71: 65-72. PMID 11781381  0.72
2001 Salvemini D, Mazzon E, Dugo L, Serraino I, De Sarro A, Caputi AP, Cuzzocrea S. Amelioration of joint disease in a rat model of collagen-induced arthritis by M40403, a superoxide dismutase mimetic Arthritis and Rheumatism. 44: 2909-2921. PMID 11762952 DOI: 10.1002/1529-0131(200112)44:12<2909::AID-ART479>3.0.CO;2-#  0.72
2001 Cuzzocrea S, Mazzon E, Dugo L, Caputi AP, Riley DP, Salvemini D. Protective effects of M40403, a superoxide dismutase mimetic, in a rodent model of colitis European Journal of Pharmacology. 432: 79-89. PMID 11734191 DOI: 10.1016/S0014-2999(01)01427-3  0.72
2001 Coppey LJ, Gellett JS, Davidson EP, Dunlap JA, Lund DD, Salvemini D, Yorek MA. Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve British Journal of Pharmacology. 134: 21-29. PMID 11522593  0.72
2001 Mollace V, Nottet HSLM, Clayette P, Turco MC, Muscoli C, Salvemini D, Perno CF. Oxidative stress and neuroAIDS: Triggers, modulators and novel antioxidants Trends in Neurosciences. 24: 411-416. PMID 11410272 DOI: 10.1016/S0166-2236(00)01819-1  0.72
2001 Salvemini D, Mazzon E, Dugo L, Riley DP, Serraino I, Caputi AP, Cuzzocrea S. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403 British Journal of Pharmacology. 132: 815-827. PMID 11181422  0.72
2001 Cuzzocrea S, Riley DP, Caputi AP, Salvemini D. Antioxidant therapy: A new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury Pharmacological Reviews. 53: 135-159. PMID 11171943  0.72
2001 Cuzzocrea S, Mazzon E, Dugo L, Caputi AP, Aston K, Riley DP, Salvemini D. Protective effects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion British Journal of Pharmacology. 132: 19-29. PMID 11156557  0.72
2000 Salvemini D, Riley DP. Nonpeptidyl mimetics of superoxide dismutase in clinical therapies for diseases Cellular and Molecular Life Sciences. 57: 1489-1492. PMID 11092442  0.72
2000 Macarthur H, Westfall TC, Riley DP, Misko TP, Salvemini D. Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock. Proceedings of the National Academy of Sciences of the United States of America. 97: 9753-8. PMID 10944234  0.72
2000 Cuzzocrea S, Misko TP, Costantino G, Mazzon E, Micali A, Caputi AP, Macarthur H, Salvemini D. Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion Faseb Journal. 14: 1061-1072. PMID 10834927  0.72
2000 Cross AH, San M, Stern MK, Keeling RM, Salvemini D, Misko TP. A catalyst of peroxynitrite decomposition inhibits murine experimental autoimmune encephalomyelitis. Journal of Neuroimmunology. 107: 21-8. PMID 10808047 DOI: 10.1016/S0165-5728(00)00242-3  0.72
2000 Salvemini D, Riley DP. M40403. Superoxide dismutase mimetic Drugs of the Future. 25: 1027-1033.  0.72
1999 Masini E, Salvemini D, Ndisang JF, Gai P, Berni L, Moncini M, Bianchi S, Mannaioni PF. Cardioprotective activity of endogenous and exogenous nitric oxide on ischaemia reperfusion injury in isolated guinea pig hearts Inflammation Research. 48: 561-568. PMID 10598011 DOI: 10.1007/s000110050504  0.72
1999 Salvemini D, Wang ZQ, Zweier JL, Samouilov A, Macarthur H, Misko TP, Currie MG, Cuzzocrea S, Sikorski JA, Riley DP. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats Science. 286: 304-306. PMID 10514375 DOI: 10.1126/science.286.5438.304  0.72
1999 Salvemini D, Riley DP, Lennon PJ, Wang ZQ, Currie MG, Macarthur H, Misko TP. Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage. British Journal of Pharmacology. 127: 685-92. PMID 10401559 DOI: 10.1038/sj.bjp.0702604  0.72
1998 Misko TP, Highkin MK, Veenhuizen AW, Manning PT, Stern MK, Currie MG, Salvemini D. Characterization of the cytoprotective action of peroxynitrite decomposition catalysts Journal of Biological Chemistry. 273: 15646-15653. PMID 9624158 DOI: 10.1074/jbc.273.25.15646  0.72
1998 Salvemini D, Wang ZQ, Stern MK, Currie MG, Misko TP. Peroxynitrite decomposition catalysts: Therapeutics for peroxynitrite- mediated pathology Proceedings of the National Academy of Sciences of the United States of America. 95: 2659-2663. PMID 9482943 DOI: 10.1073/pnas.95.5.2659  0.72
1998 Salvemini D, Marino MH. Inducible nitric oxide synthase and inflammation Expert Opinion On Investigational Drugs. 7: 65-75. DOI: 10.1517/13543784.7.1.65  0.72
1998 Salvemini D, Jensen MP, Riley DP, Misko TP. Therapeutic manipulations of peroxynitrite Drug News and Perspectives. 11: 204-211.  0.72
1997 Salvemini D. Regulation of cyclooxygenase enzymes by nitric oxide Cellular and Molecular Life Sciences. 53: 576-582. PMID 9312403 DOI: 10.1007/s000180050074  0.72
1996 Salvemini D. Preclinical industrial research Trends in Pharmacological Sciences. 17: 58-60. PMID 8929844 DOI: 10.1016/0165-6147(96)81578-1  0.72
1996 Seibert K, Masferrer JL, Needleman P, Salvemini D. Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney. British Journal of Pharmacology. 117: 1016-20. PMID 8882591  0.72
1996 Salvemini D, Wang ZQ, Bourdon DM, Stern MK, Currie MG, Manning PT. Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema European Journal of Pharmacology. 303: 217-220. PMID 8813572 DOI: 10.1016/0014-2999(96)00140-9  0.72
1996 Salvemini D, Wang ZQ, Wyatt PS, Bourdon DM, Marino MH, Manning PT, Currie MG. Nitric oxide: A key mediator in the early and late phase of carrageenan-induced rat paw inflammation British Journal of Pharmacology. 118: 829-838. PMID 8799551  0.72
1996 Salvemini D, Masferrer JL. Interactions of nitric oxide with cyclooxygenase: In vitro, ex vivo, and in vivo studies Methods in Enzymology. 269: 12-25. PMID 8791633  0.72
1996 Masini E, Salvemini D, Mugnai L, Bello MG, Bani D, Mannaioni PF. The effect of relaxin on myocardial ischaemia-reperfusion injury and histamine release in vitro and in vivo Inflammation Research. 45. PMID 8696915  0.72
1996 Salvemini D, Currie MG, Mollace V. Nitric oxide-mediated cyclooxygenase activation. A key event in the antiplatelet effects of nitrovasodilators Journal of Clinical Investigation. 97: 2562-2568. PMID 8647949  0.72
1996 Salvemini D, Seibert K, Marino MH. New concepts in inflammation and therapy Drug News and Perspectives. 9: 204-219.  0.72
1995 Isakson P, Seibert K, Masferrer J, Salvemini D, Lee L, Needleman P. Discovery of a better aspirin. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 23: 49-54. PMID 7732896  0.72
1995 Salvemini D, Settle SL, Masferrer JL, Seibert K, Currie MG, Needleman P. Regulation of prostaglandin production by nitric oxide; an in vivo analysis. British Journal of Pharmacology. 114: 1171-8. PMID 7542531  0.72
1995 Salvemini D, Manning PT, Zweifel BS, Seibert K, Connor J, Currie MG, Needleman P, Masferrer JL. Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors. The Journal of Clinical Investigation. 96: 301-8. PMID 7542281 DOI: 10.1172/JCI118035  0.72
1995 Salvemini D, Seibert K, Masferrer JL, Settle SL, Misko TP, Currie MG, Needleman P. Nitric oxide and the cyclooxygenase pathway. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 23: 491-3. PMID 7537440  0.72
1994 Pistelli A, Mollace V, Nistico G, Salvemini D, Vane J. Nitroblue tetrazolium inhibits oxidation of glyceryl trinitrate to nitric oxide in bovine aortic smooth muscle cells Biochemical Pharmacology. 47: 1737-1742. PMID 8204090 DOI: 10.1016/0006-2952(94)90300-X  0.72
1994 Salvemini D, Seibert K, Masferrer JL, Misko TP, Currie MG, Needleman P. Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. The Journal of Clinical Investigation. 93: 1940-7. PMID 7514189 DOI: 10.1172/JCI117185  0.72
1994 Salvemini D, Mollace V. Roles and therapeutic implications of nitric oxide in the cardiovascular system Drug News and Perspectives. 7: 158-166.  0.72
1993 Salvemini D, Botting R. Modulation of platelet function by free radicals and free-radical scavengers Trends in Pharmacological Sciences. 14: 36-42. PMID 8480372 DOI: 10.1016/0165-6147(93)90028-I  0.72
1993 Salvemini D, Pistelli A, Vane J. Conversion of glyceryl trinitrate to nitric oxide in tolerant and non-tolerant smooth muscle and endothelial cells British Journal of Pharmacology. 108: 162-169. PMID 8381319  0.72
1993 Salvemini D, Pistelli A, Mollace V. Release of nitric oxide from glyceryl trinitrate by captopril but not enalaprilat: In vitro and in vivo studies British Journal of Pharmacology. 109: 430-436. PMID 8358544  0.72
1993 Salvemini D, Pistelli A, Anggard E. Vascular and anti-platelet actions of 1,2- and 1,3-glyceryl dinitrate British Journal of Pharmacology. 110: 937-942. PMID 8298817  0.72
1993 Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P. Nitric oxide activates cyclooxygenase enzymes. Proceedings of the National Academy of Sciences of the United States of America. 90: 7240-4. PMID 7688473  0.72
1993 Misko TP, Schilling RJ, Salvemini D, Moore WM, Currie MG. A fluorometric assay for the measurement of nitrite in biological samples Analytical Biochemistry. 214: 11-16. PMID 7504409 DOI: 10.1006/abio.1993.1449  0.72
1993 Salvemini D, Botting R. Pharmacological intervention in the pathophysiology of oxidant injury Drug News and Perspectives. 6: 274-278.  0.72
1992 Salvemini D, Pistelli A, Mollace V, Änggård E, Vane J. The metabolism of glyceryl trinitrate to nitric oxide in the macrophage cell line J774 and its induction by Escherichia coli lipopolysaccharide Biochemical Pharmacology. 44: 17-24. PMID 1378739 DOI: 10.1016/0006-2952(92)90032-E  0.72
1992 Salvemini D, Mollace V, Pistelli A, Anggard E, Vane J. Cultured astrocytoma cells generate a nitric oxide-like factor from endogenous L-arginine and glyceryl trinitrate: Effect of E. coli lipopolysaccharide British Journal of Pharmacology. 106: 931-936. PMID 1327394  0.72
1992 Gryglewski RJ, Zembowicz A, Salvemini D, Taylor GW, Vane JR. Modulation of the pharmacological actions of nitrovasodilators by methylene blue and pyocyanin British Journal of Pharmacology. 106: 838-845. PMID 1327388  0.72
1992 Salvemini D, Mollace V, Pistelli A, Anggard E, Vane J. Metabolism of glyceryl trinitrate to nitric oxide by endothelial cells and smooth muscle cells and its induction by Escherichia coli lipopolysaccharide Proceedings of the National Academy of Sciences of the United States of America. 89: 982-986. PMID 1310543  0.72
1991 Mannaioni PF, Masini E, Pistelli A, Salvemini D, Vane JR. Mast cells as a source of superoxide anions and nitric oxide-like factor: Relevance to histamine release International Journal of Tissue Reactions. 13: 271-278. PMID 1726322  0.72
1991 Mollace V, Salvemini D, Vane J. Studies on the importance of the proposed release of nitric oxide from platelets Thrombosis Research. 65: 533-542. PMID 1725563 DOI: 10.1016/0049-3848(91)90327-S  0.72
1991 Mollace V, Salvemini D, Anggard E, Vane J. Nitric oxide from vascular smooth muscle cells: Regulation of platelet reactivity and smooth muscle cell guanylate cyclase British Journal of Pharmacology. 104: 633-638. PMID 1724627  0.72
1991 Masini E, Salvemini D, Pistelli A, Mannaioni PF, Vane JR. Rat mast cells synthesize a nitric oxide like-factor which modulates the release of histamine Agents and Actions. 33: 61-63. PMID 1716838 DOI: 10.1007/BF01993127  0.72
1991 Salvemini D, Radziszewski W, Mollace V, Moore A, Willoughby D, Vane J. Diphenylene iodonium, an inhibitor of free radical formation, inhibits platelet aggregation European Journal of Pharmacology. 199: 15-18. PMID 1716574 DOI: 10.1016/0014-2999(91)90631-Y  0.72
1991 Mollace V, Salvemini D, Sessa WC, Vane JR. Inhibition of human platelet aggregation by endothelium-derived relaxing factor, sodium nitroprusside or lloprost is potentiated by captopril and reduced thiols Journal of Pharmacology and Experimental Therapeutics. 258: 820-823. PMID 1716310  0.72
1991 Masini E, Mannaioni PF, Pistelli A, Salvemini D, Vane J. Impairment of the L-arginine-nitric oxide pathway in mast cells from spontaneously hypertensive rats Biochemical and Biophysical Research Communications. 177: 1178-1182. PMID 1711845 DOI: 10.1016/0006-291X(91)90664-S  0.72
1991 Mannaioni PF, Masini E, Pistelli A, Salvemini D, Viale JR. Rat mast cells inhibit platelet aggregation by releasing a nitric oxide-like factor: Influence of histamine release Agents and Actions. 33: 423-428. PMID 1711277  0.72
1991 Salvemini D, De Nucci G, Vane JR. Superoxide dismutase cooperates with prostacyclin to inhibit platelet aggregation: a comparative study in washed platelets and platelet rich plasma Thrombosis and Haemostasis. 65: 421-424. PMID 1647553  0.72
1991 Salvemini D, Masini E, Pistelli A, Mannaioni PF, Vane J. Nitric oxide: A regulatory mediator of mast cell reactivity Journal of Cardiovascular Pharmacology. 17.  0.72
1990 Mollace V, Salvemini D, Änggård E, Vane J. Cultured astrocytoma cells inhibit platelet aggregation by releasing a nitric oxide-like factor Biochemical and Biophysical Research Communications. 172: 564-569. PMID 2241954 DOI: 10.1016/0006-291X(90)90710-5  0.72
1990 Salvemini D, Korbut R, Änggård E, Vane J. Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide Proceedings of the National Academy of Sciences of the United States of America. 87: 2593-2597. PMID 2181441  0.72
1990 Salvemini D, Masini E, Anggard E, Mannaioni PF, Vane J. Synthesis of a nitric oxide-like factor from L-arginine by rat serosal mast cells: Stimulation of guanylate cyclase and inhibition of platelet aggregation Biochemical and Biophysical Research Communications. 169: 596-601. PMID 1972620 DOI: 10.1016/0006-291X(90)90372-T  0.72
1990 Salvemini D, Radziszewski W, Korbut R, Vane J. The use of oxyhaemoglobin to explore the events underlying inhibition of platelet aggregation induced by NO or NO-donors British Journal of Pharmacology. 101: 991-995. PMID 1707709  0.72
1990 Mannaioni PF, Masini E, Salvemini D, Pistelli A, Korbut R, Vane JR. Mast cell derived relaxing factor and the effect of nitric oxide generators on mast cell histamine release European Journal of Pharmacology. 183: 711. DOI: 10.1016/0014-2999(90)92505-D  0.72
1990 Salvemini D, Botting R. The effect of free radical scavengers on platelet adhesion and aggregation. A rational approach to pharmacological intervention in oxidant injury where platelets have been implicated will be of benefit to all those interested in the pathophysiology of not only cardiovascular diseases, but also of cancer and aging Drug News and Perspectives. 3: 202-212.  0.72
1990 Salvemini D, Botting R. EDRF and EDRF-related substances Drug News and Perspectives. 3: 506-510.  0.72
1990 Salvemini D, Korbut R, Vane JR. (N(G)-monomethyl-L-arginine inhibits release of a nitric oxide-like substance induced by E. coli lipopolysaccharide in the mouse macrophage cell line, J774 Nitric Oxide From L-Arginine: a Bioregulatory System: Proceedings of a Symposium On Biological Importance of Nitric Oxide. Ics897. 267-274.  0.72
1990 Radziszewski W, Salvemini D, Korbut R, Vane JR. Cyclic nucleotides and synergistic inhibition of platelet aggregation by sodium nitroprusside and iloprost Journal of Physiology. 425.  0.72
1989 Salvemini D, De Nucci G, Sneddon JM, Vane JR. Superoxide anions enhance platelet adhesion and aggregation British Journal of Pharmacology. 97: 1145-1150. PMID 2551440  0.72
1989 Salvemini D, De Nucci G, Gryglewski RJ, Vane JR. Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor Proceedings of the National Academy of Sciences of the United States of America. 86: 6328-6332. PMID 2548208  0.72
1989 Salvemini D, Korbut R, Änggård E, Vane JR. Lipopolysaccharide increases release of a nitric oxide-like factor from endothelial cells European Journal of Pharmacology. 171: 135-136. PMID 2515068 DOI: 10.1016/0014-2999(89)90437-8  0.72
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