Adam J. Dupuy - Publications

Affiliations: 
Anatomy & Cell Biology University of Iowa, Iowa City, IA 
Area:
Cell Biology, Molecular Biology, Genetics

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Rogers LM, Wang Z, Mott SL, Dupuy AJ, Weiner GJ. A genetic screen to identify gain- and loss-of-function modifications that enhance T-cell infiltration into tumors. Cancer Immunology Research. PMID 32611665 DOI: 10.1158/2326-6066.CIR-20-0056  0.52
2020 Vanneste M, Feddersen CR, Varzavand A, Zhu EY, Foley T, Zhao L, Holt KH, Milhem M, Piper R, Stipp CS, Dupuy AJ, Henry MD. Functional Genomic Screening Independently Identifies CUL3 as a Mediator of Vemurafenib Resistance via Src-Rac1 Signaling Axis. Frontiers in Oncology. 10: 442. PMID 32346533 DOI: 10.3389/fonc.2020.00442  0.6
2019 Feddersen CR, Schillo JL, Varzavand A, Vaughn HR, Wadsworth LS, Voigt AP, Zhu EY, Jennings BM, Mullen SA, Bobera J, Riordan JD, Stipp CS, Dupuy AJ. Src-dependent DBL family members drive resistance to vemurafenib in human melanoma. Cancer Research. PMID 31416844 DOI: 10.1158/0008-5472.CAN-19-0244  0.8
2019 Guimaraes-Young A, Feddersen CR, Dupuy AJ. Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics. Frontiers in Oncology. 9: 611. PMID 31338332 DOI: 10.3389/fonc.2019.00611  0.6
2019 Feddersen CR, Wadsworth LS, Zhu EY, Vaughn HR, Voigt AP, Riordan JD, Dupuy AJ. A simplified transposon mutagenesis method to perform phenotypic forward genetic screens in cultured cells. Bmc Genomics. 20: 497. PMID 31208320 DOI: 10.1186/s12864-019-5888-6  0.8
2018 Ziyad S, Riordan JD, Cavanaugh AM, Su T, Hernandez GE, Hilfenhaus G, Morselli M, Huynh K, Wang K, Chen JN, Dupuy AJ, Iruela-Arispe ML. A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis. Cell Reports. 22: 1211-1224. PMID 29386109 DOI: 10.1016/j.celrep.2018.01.017  0.8
2017 Rauckhorst AJ, Gray LR, Sheldon RD, Fu X, Pewa AD, Feddersen CR, Dupuy AJ, Gibson-Corley KN, Cox JE, Burgess SC, Taylor EB. The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity. Molecular Metabolism. 6: 1468-1479. PMID 29107293 DOI: 10.1016/j.molmet.2017.09.002  0.6
2017 Tschida BR, Temiz NA, Kuka TP, Lee LA, Riordan JD, Tierrablanca CA, Hullsiek R, Wagner S, Hudson WA, Linden MA, Amin K, Beckmann PJ, Heuer RA, Sarver AL, Yang JD, ... ... Dupuy AJ, et al. Sleeping Beauty insertional mutagenesis in mice identifies drivers of steatosis-associated hepatic tumor. Cancer Research. PMID 28993411 DOI: 10.1158/0008-5472.CAN-17-2281  0.8
2017 Riordan JD, Feddersen CR, Tschida BR, Jackson P, Keng VW, Linden MA, Amin K, Stipp CS, Largaespada DA, Dupuy AJ. Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma. Hepatology (Baltimore, Md.). PMID 28961327 DOI: 10.1002/hep.29565  0.8
2017 Montero-Conde C, Leandro-Garcia LJ, Chen X, Oler G, Ruiz-Llorente S, Ryder M, Landa I, Sanchez-Vega F, La K, Ghossein RA, Bajorin DF, Knauf JA, Riordan JD, Dupuy AJ, Fagin JA. Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene. Proceedings of the National Academy of Sciences of the United States of America. PMID 28584132 DOI: 10.1073/pnas.1702723114  0.8
2015 Temiz NA, Moriarity BS, Wolf NK, Riordan JD, Dupuy AJ, Largaespada DA, Sarver AL. RNA sequencing of Sleeping Beauty transposon-induced tumors detect transposon-RNA fusions allowing precision analyses of forward genetic cancer screens. Genome Research. PMID 26553456 DOI: 10.1101/gr.188649.114  0.52
2015 Mann MB, Black MA, Jones DJ, Ward JM, Yew CC, Newberg JY, Dupuy AJ, Rust AG, Bosenberg MW, McMahon M, Print CG, Copeland NG, Jenkins NA. Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma. Nature Genetics. 47: 486-95. PMID 25848750 DOI: 10.1038/ng.3275  0.52
2015 Smith RP, Riordan JD, Feddersen CR, Dupuy AJ. A Hybrid Adenoviral Vector System Achieves Efficient Long-Term Gene Expression in the Liver via piggyBac Transposition. Human Gene Therapy. 26: 377-85. PMID 25808258 DOI: 10.1089/hum.2014.123  0.52
2015 Thiel WH, Thiel KW, Flenker KS, Bair T, Dupuy AJ, McNamara JO, Miller FJ, Giangrande PH. Cell-internalization SELEX: method for identifying cell-internalizing RNA aptamers for delivering siRNAs to target cells. Methods in Molecular Biology (Clifton, N.J.). 1218: 187-99. PMID 25319652 DOI: 10.1007/978-1-4939-1538-5_11  0.52
2014 Riordan JD, Drury LJ, Smith RP, Brett BT, Rogers LM, Scheetz TE, Dupuy AJ. Sequencing methods and datasets to improve functional interpretation of sleeping beauty mutagenesis screens. Bmc Genomics. 15: 1150. PMID 25526783 DOI: 10.1186/1471-2164-15-1150  0.52
2014 Gibson-Corley KN, Rogers LM, Goeken A, Dupuy AJ, Meyerholz DK. Keratoacanthoma Pathobiology in Mouse Models. Diseases (Basel, Switzerland). 2: 106-119. PMID 25309748 DOI: 10.3390/diseases2020106  0.52
2014 Zhang Z, Kim K, Li X, Moreno M, Sharp T, Goodheart MJ, Safe S, Dupuy AJ, Amendt BA. MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression. Molecular Cancer Therapeutics. 13: 1942-51. PMID 24785257 DOI: 10.1158/1535-7163.MCT-13-1000  0.52
2014 Lim L, Balakrishnan A, Huskey N, Jones KD, Jodari M, Ng R, Song G, Riordan J, Anderton B, Cheung ST, Willenbring H, Dupuy A, Chen X, Brown D, Chang AN, et al. MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer. Hepatology (Baltimore, Md.). 59: 202-15. PMID 23913442 DOI: 10.1002/hep.26662  0.52
2013 DeZwaan-McCabe D, Riordan JD, Arensdorf AM, Icardi MS, Dupuy AJ, Rutkowski DT. The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis. Plos Genetics. 9: e1003937. PMID 24367269 DOI: 10.1371/journal.pgen.1003937  0.52
2013 Riordan JD, Dupuy AJ. Domesticated transposable element gene products in human cancer. Mobile Genetic Elements. 3: e26693. PMID 24251072 DOI: 10.4161/mge.26693  0.8
2013 Riordan JD, Keng VW, Tschida BR, Scheetz TE, Bell JB, Podetz-Pedersen KM, Moser CD, Copeland NG, Jenkins NA, Roberts LR, Largaespada DA, Dupuy AJ. Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis. Plos Genetics. 9: e1003441. PMID 23593033 DOI: 10.1371/journal.pgen.1003441  0.52
2013 Zanesi N, Balatti V, Riordan J, Burch A, Rizzotto L, Palamarchuk A, Cascione L, Lagana A, Dupuy AJ, Croce CM, Pekarsky Y. A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model. Blood. 121: 4355-8. PMID 23591791 DOI: 10.1182/blood-2013-02-486035  0.52
2013 Rogers LM, Olivier AK, Meyerholz DK, Dupuy AJ. Adaptive immunity does not strongly suppress spontaneous tumors in a Sleeping Beauty model of cancer. Journal of Immunology (Baltimore, Md. : 1950). 190: 4393-9. PMID 23475219 DOI: 10.4049/jimmunol.1203227  0.52
2013 Rogers LM, Riordan JD, Swick BL, Meyerholz DK, Dupuy AJ. Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer. The Journal of Investigative Dermatology. 133: 1863-9. PMID 23426136 DOI: 10.1038/jid.2013.77  0.52
2013 Keng VW, Sia D, Sarver AL, Tschida BR, Fan D, Alsinet C, Solé M, Lee WL, Kuka TP, Moriarity BS, Villanueva A, Dupuy AJ, Riordan JD, Bell JB, Silverstein KA, et al. Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR. Hepatology (Baltimore, Md.). 57: 120-30. PMID 22899566 DOI: 10.1002/hep.26004  0.52
2013 Quintana RM, Dupuy AJ, Bravo A, Casanova ML, Alameda JP, Page A, Sánchez-Viera M, Ramírez A, Navarro M. A transposon-based analysis of gene mutations related to skin cancer development. The Journal of Investigative Dermatology. 133: 239-48. PMID 22832494 DOI: 10.1038/jid.2012.245  0.52
2012 Mann KM, Ward JM, Yew CC, Kovochich A, Dawson DW, Black MA, Brett BT, Sheetz TE, Dupuy AJ, Chang DK, Biankin AV, Waddell N, Kassahn KS, Grimmond SM, et al. Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America. 109: 5934-41. PMID 22421440 DOI: 10.1073/pnas.1202490109  0.52
2012 Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJ, Witt H, Croul S, Bouffet E, Fults DW, Eberhart CG, Garzia L, Van Meter T, Zagzag D, Jabado N, Schwartzentruber J, et al. Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature. 482: 529-33. PMID 22343890 DOI: 10.1038/nature10825  0.52
2012 Berquam-Vrieze KE, Swing DA, Tessarollo L, Dupuy AJ. Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1. Genesis (New York, N.Y. : 2000). 50: 112-8. PMID 21898766 DOI: 10.1002/dvg.20798  0.52
2011 Brett BT, Berquam-Vrieze KE, Nannapaneni K, Huang J, Scheetz TE, Dupuy AJ. Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors. Plos One. 6: e24668. PMID 21931803 DOI: 10.1371/journal.pone.0024668  0.52
2011 Berquam-Vrieze KE, Nannapaneni K, Brett BT, Holmfeldt L, Ma J, Zagorodna O, Jenkins NA, Copeland NG, Meyerholz DK, Knudson CM, Mullighan CG, Scheetz TE, Dupuy AJ. Cell of origin strongly influences genetic selection in a mouse model of T-ALL. Blood. 118: 4646-56. PMID 21828136 DOI: 10.1182/blood-2011-03-343947  0.52
2011 Thiel WH, Bair T, Wyatt Thiel K, Dassie JP, Rockey WM, Howell CA, Liu XY, Dupuy AJ, Huang L, Owczarzy R, Behlke MA, McNamara JO, Giangrande PH. Nucleotide bias observed with a short SELEX RNA aptamer library. Nucleic Acid Therapeutics. 21: 253-63. PMID 21793789 DOI: 10.1089/nat.2011.0288  0.52
2011 McGrail M, Hatler JM, Kuang X, Liao HK, Nannapaneni K, Watt KE, Uhl JD, Largaespada DA, Vollbrecht E, Scheetz TE, Dupuy AJ, Hostetter JM, Essner JJ. Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish. Plos One. 6: e18826. PMID 21533036 DOI: 10.1371/journal.pone.0018826  0.52
2011 Starr TK, Scott PM, Marsh BM, Zhao L, Than BL, O'Sullivan MG, Sarver AL, Dupuy AJ, Largaespada DA, Cormier RT. A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 5765-70. PMID 21436051 DOI: 10.1073/pnas.1018012108  0.52
2011 Riordan JD, Rogers LM, Berquam-Vrieze KE, Dupuy AJ. Sleeping beauty models of cancer Insertional Mutagenesis Strategies in Cancer Genetics. 113-130. DOI: 10.1007/978-1-4419-7656-7_5  0.52
2011 Dupuy AJ, Largaespada DA. Insertional mutagenesis strategies in cancer genetics Insertional Mutagenesis Strategies in Cancer Genetics. 1-200. DOI: 10.1007/978-1-4419-7656-7  0.52
2010 Dupuy AJ. Current applications of transposons in mouse genetics. Methods in Enzymology. 477: 53-70. PMID 20699136 DOI: 10.1016/S0076-6879(10)77004-X  0.52
2010 Dupuy AJ. Transposon-based screens for cancer gene discovery in mouse models. Seminars in Cancer Biology. 20: 261-8. PMID 20478384 DOI: 10.1016/j.semcancer.2010.05.003  0.52
2010 Wang DH, Clemons NJ, Miyashita T, Dupuy AJ, Zhang W, Szczepny A, Corcoran-Schwartz IM, Wilburn DL, Montgomery EA, Wang JS, Jenkins NA, Copeland NA, Harmon JW, Phillips WA, Watkins DN. Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia. Gastroenterology. 138: 1810-22. PMID 20138038 DOI: 10.1053/j.gastro.2010.01.048  0.52
2009 Collier LS, Adams DJ, Hackett CS, Bendzick LE, Akagi K, Davies MN, Diers MD, Rodriguez FJ, Bender AM, Tieu C, Matise I, Dupuy AJ, Copeland NG, Jenkins NA, Hodgson JG, et al. Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality. Cancer Research. 69: 8429-37. PMID 19843846 DOI: 10.1158/0008-5472.CAN-09-1760  0.52
2009 Dupuy AJ, Rogers LM, Kim J, Nannapaneni K, Starr TK, Liu P, Largaespada DA, Scheetz TE, Jenkins NA, Copeland NG. A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Research. 69: 8150-6. PMID 19808965 DOI: 10.1158/0008-5472.CAN-09-1135  0.52
2009 Starr TK, Allaei R, Silverstein KA, Staggs RA, Sarver AL, Bergemann TL, Gupta M, O'Sullivan MG, Matise I, Dupuy AJ, Collier LS, Powers S, Oberg AL, Asmann YW, Thibodeau SN, et al. A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science (New York, N.Y.). 323: 1747-50. PMID 19251594 DOI: 10.1126/science.1163040  0.52
2009 Keng VW, Villanueva A, Chiang DY, Dupuy AJ, Ryan BJ, Matise I, Silverstein KA, Sarver A, Starr TK, Akagi K, Tessarollo L, Collier LS, Powers S, Lowe SW, Jenkins NA, et al. A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nature Biotechnology. 27: 264-74. PMID 19234449 DOI: 10.1038/nbt.1526  0.52
2008 Su Q, Prosser HM, Campos LS, Ortiz M, Nakamura T, Warren M, Dupuy AJ, Jenkins NA, Copeland NG, Bradley A, Liu P. A DNA transposon-based approach to validate oncogenic mutations in the mouse. Proceedings of the National Academy of Sciences of the United States of America. 105: 19904-9. PMID 19064922 DOI: 10.1073/pnas.0807785105  0.52
2006 Dupuy AJ, Jenkins NA, Copeland NG. Sleeping beauty: a novel cancer gene discovery tool. Human Molecular Genetics. 15: R75-9. PMID 16651372 DOI: 10.1093/hmg/ddl061  0.52
2005 Collier LS, Carlson CM, Ravimohan S, Dupuy AJ, Largaespada DA. Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature. 436: 272-6. PMID 16015333 DOI: 10.1038/nature03681  0.52
2005 Dupuy AJ, Akagi K, Largaespada DA, Copeland NG, Jenkins NA. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature. 436: 221-6. PMID 16015321 DOI: 10.1038/nature03691  0.52
2003 Carlson CM, Dupuy AJ, Fritz S, Roberg-Perez KJ, Fletcher CF, Largaespada DA. Transposon mutagenesis of the mouse germline. Genetics. 165: 243-56. PMID 14504232  0.52
2003 Belur LR, Frandsen JL, Dupuy AJ, Ingbar DH, Largaespada DA, Hackett PB, Scott McIvor R. Gene insertion and long-term expression in lung mediated by the Sleeping Beauty transposon system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 501-7. PMID 12946324 DOI: 10.1016/S1525-0016(03)00211-9  0.52
2003 Geurts AM, Yang Y, Clark KJ, Liu G, Cui Z, Dupuy AJ, Bell JB, Largaespada DA, Hackett PB. Gene transfer into genomes of human cells by the sleeping beauty transposon system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 108-17. PMID 12842434 DOI: 10.1016/S1525-0016(03)00099-6  0.52
2002 Dupuy AJ, Clark K, Carlson CM, Fritz S, Davidson AE, Markley KM, Finley K, Fletcher CF, Ekker SC, Hackett PB, Horn S, Largaespada DA. Mammalian germ-line transgenesis by transposition. Proceedings of the National Academy of Sciences of the United States of America. 99: 4495-9. PMID 11904379 DOI: 10.1073/pnas.062630599  0.52
2001 Dupuy AJ, Fritz S, Largaespada DA. Transposition and gene disruption in the male germline of the mouse Genesis. 30: 82-88. PMID 11416868 DOI: 10.1002/gene.1037  0.52
2001 Dupuy AJ, Morgan K, Von Lintig FC, Shen H, Acar H, Hasz DE, Jenkins NA, Copeland NG, Boss GR, Largaespada DA. Activation of the Rap1 Guanine Nucleotide Exchange Gene, CalDAG-GEF I, in BXH-2 Murine Myeloid Leukemia Journal of Biological Chemistry. 276: 11804-11811. PMID 11278453 DOI: 10.1074/jbc.M008970200  0.52
1999 Li J, Shen H, Himmel KL, Dupuy AJ, Largaespada DA, Nakamura T, Shaughnessy JD, Jenkins NA, Copeland NG. Leukaemia disease genes: large-scale cloning and pathway predictions. Nature Genetics. 23: 348-53. PMID 10610183 DOI: 10.1038/15531  0.52
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