| Year |
Citation |
Score |
| 2023 |
Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, ... ... Kitsis RN, et al. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death and Differentiation. PMID 37100955 DOI: 10.1038/s41418-023-01153-w |
0.356 |
|
| 2022 |
McKimpson WM, Kitsis RN. Inducing and measuring apoptotic cell death in mouse pancreatic β-cells and in isolated islets. Star Protocols. 3: 101287. PMID 35719268 DOI: 10.1016/j.xpro.2022.101287 |
0.747 |
|
| 2021 |
McKimpson WM, Chen Y, Irving JA, Zheng M, Weinberger J, Tan WLW, Tiang Z, Jagger AM, Chua SC, Pessin JE, Foo RS, Lomas DA, Kitsis RN. Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes. Developmental Cell. PMID 33667344 DOI: 10.1016/j.devcel.2021.02.011 |
0.744 |
|
| 2021 |
Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-Codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, ... ... Kitsis RN, et al. Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy. Science Translational Medicine. 13. PMID 33597260 DOI: 10.1126/scitranslmed.abf0891 |
0.354 |
|
| 2021 |
Nam YJ, Mani K, Ashton AW, Peng CF, Krishnamurthy B, Hayakawa Y, Lee P, Korsmeyer SJ, Kitsis RN. Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Molecular Cell. 81: 638. PMID 33545060 DOI: 10.1016/j.molcel.2021.01.018 |
0.684 |
|
| 2020 |
Chen F, Amgalan D, Kitsis RN, Pessin JE, Feng D. ATG16L1 autophagy pathway regulates BAX protein levels and programmed cell death. The Journal of Biological Chemistry. PMID 32848017 DOI: 10.1074/Jbc.Ra120.013999 |
0.465 |
|
| 2020 |
Amgalan D, Garner TP, Pekson R, Jia XF, Yanamandala M, Paulino V, Liang FG, Corbalan JJ, Lee J, Chen Y, Karagiannis GS, Sanchez LR, Liang H, Narayanagari SR, Mitchell K, ... ... Kitsis RN, et al. A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy. Nature Cancer. 1: 315-328. PMID 32776015 DOI: 10.1038/S43018-020-0039-1 |
0.478 |
|
| 2020 |
Templin AT, Schmidt CR, Hogan MF, Esser N, Kitsis RN, Hull RL, Zraika S, Kahn SE. 2042-P: Loss of Apoptosis Repressor with Caspase Recruitment Domain Promotes High-Fat Diet Induced Hyperglycemia In Vivo Diabetes. 69. DOI: 10.2337/Db20-2042-P |
0.358 |
|
| 2019 |
Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, et al. Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop Circulation. 140: 1205-1216. PMID 31769940 DOI: 10.1161/Circulationaha.119.040551 |
0.319 |
|
| 2019 |
Del Re DP, Amgalan D, Linkermann A, Liu Q, Kitsis RN. Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease. Physiological Reviews. 99: 1765-1817. PMID 31364924 DOI: 10.1152/Physrev.00022.2018 |
0.501 |
|
| 2019 |
Amgalan D, Kitsis RN. A mouse model for the most common form of heart failure. Nature. 568: 324-325. PMID 30980035 DOI: 10.1038/D41586-019-00983-4 |
0.301 |
|
| 2019 |
Garner TP, Amgalan D, Reyna DE, Li S, Kitsis RN, Gavathiotis E. Small-molecule allosteric inhibitors of BAX. Nature Chemical Biology. PMID 30718816 DOI: 10.1038/S41589-018-0223-0 |
0.403 |
|
| 2018 |
Kitsis RN, Riquelme JA, Lavandero S. Heart Disease and Cancer. Circulation. 138: 692-695. PMID 30359137 DOI: 10.1161/Circulationaha.118.033907 |
0.305 |
|
| 2018 |
Feng D, Amgalan D, Singh R, Wei J, Wen J, Wei TP, McGraw TE, Kitsis RN, Pessin JE. SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy. The Journal of Clinical Investigation. PMID 30102258 DOI: 10.1172/Jci99217 |
0.464 |
|
| 2018 |
Corbalan JJ, Kitsis RN. RCAN1-Calcineurin Axis and the Set-Point for Myocardial Damage During Ischemia-Reperfusion. Circulation Research. 122: 796-798. PMID 29700078 DOI: 10.1161/Circresaha.118.312787 |
0.385 |
|
| 2018 |
Riascos-Bernal DF, Sibinga NES, Kitsis RN. PDCD5 says no to NO. Proceedings of the National Academy of Sciences of the United States of America. PMID 29666279 DOI: 10.1073/Pnas.1804491115 |
0.314 |
|
| 2018 |
Kushnir A, Santulli G, Reiken SR, Coromilas E, Godfrey SJ, Brunjes DL, Colombo PC, Yuzefpolskaya M, Sokol SI, Kitsis RN, Marks AR. Ryanodine Receptor Calcium Leak in Circulating B-Lymphocytes as a Biomarker in Heart Failure. Circulation. PMID 29593014 DOI: 10.1161/Circulationaha.117.032703 |
0.309 |
|
| 2018 |
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, ... ... Kitsis RN, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. PMID 29362479 DOI: 10.1038/S41418-017-0012-4 |
0.453 |
|
| 2018 |
Chen Y, Lee J, Zheng M, Paulino V, Garcia C, Matute JM, Li H, Kaludercic N, Owusu-Ansah E, Cuervo AM, Kitsis RN. Abstract 117: Regulation of Cardiac Mitochondrial Function by Chaperone Mediated Autophagy Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.117 |
0.368 |
|
| 2017 |
Hazan RB, Suyama K, Yao J, Liang H, Benard O, Loudig OD, Amgalan D, McKimpson WM, Phillips GR, Segall JE, Wang Y, Fineberg S, Norton L, Kitsis RN. An Akt3 splice variant lacking the serine 472 phosphorylation site promotes apoptosis and suppresses mammary tumorigenesis. Cancer Research. PMID 29038347 DOI: 10.1158/0008-5472.Can-15-1462 |
0.769 |
|
| 2017 |
Amgalan D, Pekson R, Kitsis RN. Troponin release following brief myocardial ischemia: apoptosis versus necrosis. Jacc. Basic to Translational Science. 2: 118-121. PMID 29034357 DOI: 10.1016/J.Jacbts.2017.03.008 |
0.353 |
|
| 2017 |
Amgalan D, Chen Y, Kitsis RN. Death Receptor Signaling in the Heart: Cell Survival, Apoptosis, and Necroptosis. Circulation. 136: 743-746. PMID 28827219 DOI: 10.1161/Circulationaha.117.029566 |
0.516 |
|
| 2017 |
Yanamandala M, Zhu W, Garry DJ, Kamp TJ, Hare JM, Jun HW, Yoon YS, Bursac N, Prabhu SD, Dorn GW, Bolli R, Kitsis RN, Zhang J. Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering. Journal of the American College of Cardiology. 70: 766-775. PMID 28774384 DOI: 10.1016/J.Jacc.2017.06.012 |
0.346 |
|
| 2017 |
McKimpson WM, Zheng M, Chua SC, Pessin JE, Kitsis RN. ARC is essential for maintaining pancreatic islet structure and β-cell viability during type 2 diabetes. Scientific Reports. 7: 7019. PMID 28765602 DOI: 10.1038/S41598-017-07107-W |
0.758 |
|
| 2017 |
Templin AT, Samarasekera T, Meier DT, Hogan MF, Mellati M, Crow MT, Kitsis RN, Zraika S, Hull RL, Kahn SE. Apoptosis Repressor with Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation. Diabetes. PMID 28729244 DOI: 10.2337/Db16-1352 |
0.431 |
|
| 2017 |
Moslehi J, Amgalan D, Kitsis RN. Grounding Cardio-Oncology in Basic and Clinical Science. Circulation. 136: 3-5. PMID 28674089 DOI: 10.1161/Circulationaha.117.025393 |
0.322 |
|
| 2017 |
Shires SE, Kitsis RN, Gustafsson ÅB. Beyond Mitophagy: The Diversity and Complexity of Parkin Function. Circulation Research. 120: 1234-1236. PMID 28408450 DOI: 10.1161/Circresaha.116.310179 |
0.357 |
|
| 2017 |
McKimpson WM, Kitsis RN. A New Role for the ER Unfolded Protein Response Mediator ATF6: Induction of a Generalized Antioxidant Program. Circulation Research. 120: 759-761. PMID 28254796 DOI: 10.1161/Circresaha.117.310577 |
0.734 |
|
| 2017 |
Stanley RF, Piszczatowski RT, Bartholdy B, Mitchell K, McKimpson WM, Narayanagari S, Walter D, Todorova TI, Hirsch C, Makishima H, Will B, McMahon C, Gritsman K, Maciejewski JP, Kitsis RN, et al. A myeloid tumor suppressor role for NOL3. The Journal of Experimental Medicine. PMID 28232469 DOI: 10.1084/Jem.20162089 |
0.748 |
|
| 2017 |
Hammerling BC, Najor RH, Cortez MQ, Shires SE, Leon LJ, Gonzalez ER, Boassa D, Phan S, Thor A, Jimenez RE, Li H, Kitsis RN, Dorn Ii GW, Sadoshima J, Ellisman MH, et al. A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance. Nature Communications. 8: 14050. PMID 28134239 DOI: 10.1038/Ncomms14050 |
0.395 |
|
| 2016 |
Nah J, Fernández ÁF, Kitsis RN, Levine B, Sadoshima J. Does Autophagy Mediate Cardiac Myocyte Death During Stress? Circulation Research. 119: 893-5. PMID 27688304 DOI: 10.1161/Circresaha.116.309765 |
0.485 |
|
| 2016 |
Murphy E, Ardehali H, Balaban RS, DiLisa F, Dorn GW, Kitsis RN, Otsu K, Ping P, Rizzuto R, Sack MN, Wallace D, Youle RJ. Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association. Circulation Research. 118: 1960-91. PMID 27126807 DOI: 10.1161/Res.0000000000000104 |
0.34 |
|
| 2016 |
Shirakabe A, Fritzky L, Saito T, Zhai P, Miyamoto S, Gustafsson ÅB, Kitsis RN, Sadoshima J. Evaluating mitochondrial autophagy in the mouse heart. Journal of Molecular and Cellular Cardiology. 92: 134-139. PMID 26868976 DOI: 10.1016/J.Yjmcc.2016.02.007 |
0.336 |
|
| 2015 |
McKimpson WM, Yuan Z, Zheng M, Crabtree JS, Libutti SK, Kitsis RN. The Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth. Plos One. 10: e0145792. PMID 26709830 DOI: 10.1371/Journal.Pone.0145792 |
0.738 |
|
| 2015 |
Chen H, Ruiz PD, McKimpson WM, Novikov L, Kitsis RN, Gamble MJ. MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype. Molecular Cell. 59: 719-31. PMID 26300260 DOI: 10.1016/J.Molcel.2015.07.011 |
0.74 |
|
| 2015 |
Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circulation Research. 117: 346-51. PMID 26038571 DOI: 10.1161/Circresaha.117.306859 |
0.384 |
|
| 2015 |
Maejima Y, Chen Y, Isobe M, Gustafsson ÅB, Kitsis RN, Sadoshima J. Recent progress in research on molecular mechanisms of autophagy in the heart. American Journal of Physiology. Heart and Circulatory Physiology. 308: H259-68. PMID 25398984 DOI: 10.1152/Ajpheart.00711.2014 |
0.425 |
|
| 2015 |
Dorn GW, Kitsis RN. The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble. Circulation Research. 116: 167-82. PMID 25323859 DOI: 10.1161/Circresaha.116.303554 |
0.36 |
|
| 2015 |
Chen H, Ruiz PD, McKimpson W, Novikov L, Kitsis RN, Gamble MJ. Abstract 1267: The senescence-associated secretory phenotype requires the histone variant macroH2A1 and is antagonized by ATM in a novel ER stress response Cancer Research. 75: 1267-1267. DOI: 10.1158/1538-7445.Am2015-1267 |
0.752 |
|
| 2014 |
Kung G, Dai P, Deng L, Kitsis RN. A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis. Cell Death and Differentiation. 21: 634-44. PMID 24440909 DOI: 10.1038/Cdd.2013.195 |
0.694 |
|
| 2013 |
Davis J, Kwong JQ, Kitsis RN, Molkentin JD. Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle. Plos One. 8: e82053. PMID 24312627 DOI: 10.1371/Journal.Pone.0082053 |
0.385 |
|
| 2013 |
Yang Y, Rodriguez JE, Kitsis RN. A microRNA links prolactin to peripartum cardiomyopathy. The Journal of Clinical Investigation. 123: 1925-7. PMID 23619357 DOI: 10.1172/Jci69286 |
0.325 |
|
| 2013 |
Whelan RS, Konstantinidis K, Xiao RP, Kitsis RN. Cardiomyocyte life-death decisions in response to chronic β-adrenergic signaling. Circulation Research. 112: 408-10. PMID 23371896 DOI: 10.1161/Circresaha.113.300805 |
0.785 |
|
| 2013 |
Park M, Vatner SF, Yan L, Gao S, Yoon S, Lee GJ, Xie LH, Kitsis RN, Vatner DE. Novel mechanisms for caspase inhibition protecting cardiac function with chronic pressure overload. Basic Research in Cardiology. 108: 324. PMID 23277091 DOI: 10.1007/S00395-012-0324-Y |
0.399 |
|
| 2013 |
McKimpson WM, Weinberger J, Czerski L, Zheng M, Crow MT, Pessin JE, Chua SC, Kitsis RN. The apoptosis inhibitor ARC alleviates the ER stress response to promote β-cell survival. Diabetes. 62: 183-93. PMID 22933109 DOI: 10.2337/Db12-0504 |
0.795 |
|
| 2013 |
Whelan RS, Konstantinidis K, Xiao RP, Kitsis RN. Erratum: Cardiomyocyte life-death decisions in response to chronic β-adrenergic signaling (Circulation Research (2013) 112 (408-410) DOI: 10.1161/CIRCRESAHA.113.300805) Circulation Research. 112. DOI: 10.1161/Res.0B013E31829C46A1 |
0.763 |
|
| 2013 |
James MK, Kitsis RN. Abstract 1729: Mitochondrial necrosis pathway drives tumor progression. Cancer Research. 73: 1729-1729. DOI: 10.1158/1538-7445.Am2013-1729 |
0.471 |
|
| 2012 |
Gavrilov S, Nührenberg TG, Ashton AW, Peng CF, Moore JC, Konstantinidis K, Mummery CL, Kitsis RN. Tbx6 is a determinant of cardiac and neural cell fate decisions in multipotent P19CL6 cells. Differentiation; Research in Biological Diversity. 84: 176-84. PMID 22721678 DOI: 10.1016/J.Diff.2012.04.007 |
0.599 |
|
| 2012 |
Konstantinidis K, Whelan RS, Kitsis RN. Mechanisms of cell death in heart disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 1552-62. PMID 22596221 DOI: 10.1161/Atvbaha.111.224915 |
0.814 |
|
| 2012 |
Konstantinidis K, Kitsis RN. Cardiovascular biology: Escaped DNA inflames the heart. Nature. 485: 179-80. PMID 22575953 DOI: 10.1038/485179A |
0.374 |
|
| 2012 |
Whelan RS, Konstantinidis K, Wei AC, Chen Y, Reyna DE, Jha S, Yang Y, Calvert JW, Lindsten T, Thompson CB, Crow MT, Gavathiotis E, Dorn GW, O'Rourke B, Kitsis RN. Bax regulates primary necrosis through mitochondrial dynamics. Proceedings of the National Academy of Sciences of the United States of America. 109: 6566-71. PMID 22493254 DOI: 10.1073/Pnas.1201608109 |
0.806 |
|
| 2012 |
Dorn GW, Kitsis RN. Programmed cardiomyocyte death in heart disease Muscle. 1: 423-446. DOI: 10.1016/B978-0-12-381510-1.00031-4 |
0.413 |
|
| 2011 |
Zaiman AL, Damico R, Thoms-Chesley A, Files DC, Kesari P, Johnston L, Swaim M, Mozammel S, Myers AC, Halushka M, El-Haddad H, Shimoda LA, Peng CF, Hassoun PM, Champion HC, ... Kitsis RN, et al. A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension. Circulation. 124: 2533-42. PMID 22082675 DOI: 10.1161/Circulationaha.111.034512 |
0.381 |
|
| 2011 |
Medina-Ramirez CM, Goswami S, Smirnova T, Bamira D, Benson B, Ferrick N, Segall J, Pollard JW, Kitsis RN. Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistance. Cancer Research. 71: 7705-15. PMID 22037876 DOI: 10.1158/0008-5472.Can-11-2192 |
0.769 |
|
| 2011 |
Feng D, Tang Y, Kwon H, Zong H, Hawkins M, Kitsis RN, Pessin JE. High-fat diet-induced adipocyte cell death occurs through a cyclophilin D intrinsic signaling pathway independent of adipose tissue inflammation. Diabetes. 60: 2134-43. PMID 21734017 DOI: 10.2337/Db10-1411 |
0.364 |
|
| 2011 |
Kung G, Konstantinidis K, Kitsis RN. Programmed necrosis, not apoptosis, in the heart. Circulation Research. 108: 1017-36. PMID 21493924 DOI: 10.1161/Circresaha.110.225730 |
0.727 |
|
| 2011 |
Kung G, McKimpson W, Kitsis RN. NOL3 (nucleolar protein 3 (apoptosis repressor with CARD domain)) Atlas of Genetics and Cytogenetics in Oncology and Haematology. DOI: 10.4267/2042/44736 |
0.77 |
|
| 2011 |
Medina-Ramirez CM, Gowasmi S, Smirnova T, Bamira D, Condeelis J, Segall J, Pollard JW, Kitsis RN. Abstract 4695: Apoptosis inhibitor ARC as a novel mediator of breast tumorigenesis, metastasis and chemoresistance Cancer Research. 71: 4695-4695. DOI: 10.1158/1538-7445.Am2011-4695 |
0.773 |
|
| 2010 |
Kitsis RN, Molkentin JD. Apoptotic cell death "Nixed" by an ER-mitochondrial necrotic pathway. Proceedings of the National Academy of Sciences of the United States of America. 107: 9031-2. PMID 20448198 DOI: 10.1073/Pnas.1003827107 |
0.467 |
|
| 2010 |
Wu L, Nam YJ, Kung G, Crow MT, Kitsis RN. Induction of the apoptosis inhibitor ARC by Ras in human cancers. The Journal of Biological Chemistry. 285: 19235-45. PMID 20392691 DOI: 10.1074/Jbc.M110.114892 |
0.758 |
|
| 2010 |
Whelan RS, Kaplinskiy V, Kitsis RN. Cell death in the pathogenesis of heart disease: mechanisms and significance. Annual Review of Physiology. 72: 19-44. PMID 20148665 DOI: 10.1146/Annurev.Physiol.010908.163111 |
0.818 |
|
| 2009 |
Park M, Shen YT, Gaussin V, Heyndrickx GR, Bartunek J, Resuello RR, Natividad FF, Kitsis RN, Vatner DE, Vatner SF. Apoptosis predominates in nonmyocytes in heart failure. American Journal of Physiology. Heart and Circulatory Physiology. 297: H785-91. PMID 19465551 DOI: 10.1152/Ajpheart.00310.2009 |
0.442 |
|
| 2008 |
Mercier I, Vuolo M, Jasmin JF, Medina CM, Williams M, Mariadason JM, Qian H, Xue X, Pestell RG, Lisanti MP, Kitsis RN. ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer Cell Cycle. 7: 1640-1647. PMID 18469522 DOI: 10.4161/Cc.7.11.5979 |
0.428 |
|
| 2008 |
Kitsis RN, Narula J. Introduction-cell death in heart failure. Heart Failure Reviews. 13: 107-9. PMID 18214673 DOI: 10.1007/S10741-008-9080-3 |
0.507 |
|
| 2007 |
Foo RS, Nam YJ, Ostreicher MJ, Metzl MD, Whelan RS, Peng CF, Ashton AW, Fu W, Mani K, Chin SF, Provenzano E, Ellis I, Figg N, Pinder S, Bennett MR, ... ... Kitsis RN, et al. Regulation of p53 tetramerization and nuclear export by ARC. Proceedings of the National Academy of Sciences of the United States of America. 104: 20826-31. PMID 18087040 DOI: 10.1073/Pnas.0710017104 |
0.767 |
|
| 2007 |
Whelan RS, Mani K, Kitsis RN. Nipping at cardiac remodeling. The Journal of Clinical Investigation. 117: 2751-3. PMID 17909620 DOI: 10.1172/Jci33706 |
0.787 |
|
| 2007 |
Kitsis RN, Peng CF, Cuervo AM. Eat your heart out. Nature Medicine. 13: 539-41. PMID 17479097 DOI: 10.1038/Nm0507-539 |
0.351 |
|
| 2007 |
Foo RS, Chan LK, Kitsis RN, Bennett MR. Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2. The Journal of Biological Chemistry. 282: 5529-35. PMID 17142834 DOI: 10.1074/Jbc.M609046200 |
0.453 |
|
| 2007 |
Nam YJ, Mani K, Wu L, Peng CF, Calvert JW, Foo RS, Krishnamurthy B, Miao W, Ashton AW, Lefer DJ, Kitsis RN. The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant. The Journal of Biological Chemistry. 282: 5522-8. PMID 17142452 DOI: 10.1074/Jbc.M609186200 |
0.726 |
|
| 2005 |
Li J, Scherl A, Medina F, Frank PG, Kitsis RN, Tanowitz HB, Sotgia F, Lisanti MP. Impaired phagocytosis in caveolin-1 deficient macrophages. Cell Cycle (Georgetown, Tex.). 4: 1599-607. PMID 16205123 DOI: 10.4161/Cc.4.11.2117 |
0.376 |
|
| 2005 |
Tarzami ST, Calderon TM, Deguzman A, Lopez L, Kitsis RN, Berman JW. MCP-1/CCL2 protects cardiac myocytes from hypoxia-induced apoptosis by a G(alphai)-independent pathway. Biochemical and Biophysical Research Communications. 335: 1008-16. PMID 16102724 DOI: 10.1016/J.Bbrc.2005.07.168 |
0.441 |
|
| 2005 |
Pajvani UB, Trujillo ME, Combs TP, Iyengar P, Jelicks L, Roth KA, Kitsis RN, Scherer PE. Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nature Medicine. 11: 797-803. PMID 15965483 DOI: 10.1038/Nm1262 |
0.372 |
|
| 2005 |
Mercier I, Vuolo M, Madan R, Xue X, Levalley AJ, Ashton AW, Jasmin JF, Czaja MT, Lin EY, Armstrong RC, Pollard JW, Kitsis RN. ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance. Cell Death and Differentiation. 12: 682-6. PMID 15861191 DOI: 10.1038/Sj.Cdd.4401631 |
0.382 |
|
| 2005 |
Foo RS, Mani K, Kitsis RN. Death begets failure in the heart. The Journal of Clinical Investigation. 115: 565-71. PMID 15765138 DOI: 10.1172/Jci24569 |
0.399 |
|
| 2005 |
Kitsis RN, Mann DL. Apoptosis and the heart: a decade of progress. Journal of Molecular and Cellular Cardiology. 38: 1-2. PMID 15623416 DOI: 10.1016/J.Yjmcc.2004.11.008 |
0.403 |
|
| 2004 |
Crow MT, Mani K, Nam YJ, Kitsis RN. The mitochondrial death pathway and cardiac myocyte apoptosis. Circulation Research. 95: 957-70. PMID 15539639 DOI: 10.1161/01.Res.0000148632.35500.D9 |
0.66 |
|
| 2004 |
Nam YJ, Mani K, Ashton AW, Peng CF, Krishnamurthy B, Hayakawa Y, Lee P, Korsmeyer SJ, Kitsis RN. Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Molecular Cell. 15: 901-12. PMID 15383280 DOI: 10.1016/J.Molcel.2004.08.020 |
0.727 |
|
| 2004 |
Young DA, Gavrilov S, Pennington CJ, Nuttall RK, Edwards DR, Kitsis RN, Clark IM. Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes. Biochemical and Biophysical Research Communications. 322: 759-65. PMID 15336529 DOI: 10.1016/J.Bbrc.2004.07.178 |
0.594 |
|
| 2003 |
Hayakawa Y, Chandra M, Miao W, Shirani J, Brown JH, Dorn GW, Armstrong RC, Kitsis RN. Inhibition of Cardiac Myocyte Apoptosis Improves Cardiac Function and Abolishes Mortality in the Peripartum Cardiomyopathy of Gαq Transgenic Mice Circulation. 108: 3036-3041. PMID 14638549 DOI: 10.1161/01.Cir.0000101920.72665.58 |
0.439 |
|
| 2003 |
Tarzami ST, Miao W, Mani K, Lopez L, Factor SM, Berman JW, Kitsis RN. Opposing effects mediated by the chemokine receptor CXCR2 on myocardial ischemia-reperfusion injury: recruitment of potentially damaging neutrophils and direct myocardial protection. Circulation. 108: 2387-92. PMID 14568904 DOI: 10.1161/01.Cir.0000093192.72099.9A |
0.379 |
|
| 2003 |
Mukherjee S, Belbin TJ, Spray DC, Iacobas DA, Weiss LM, Kitsis RN, Wittner M, Jelicks LA, Scherer PE, Ding A, Tanowitz HB. Microarray analysis of changes in gene expression in a murine model of chronic chagasic cardiomyopathy. Parasitology Research. 91: 187-96. PMID 12910413 DOI: 10.1007/S00436-003-0937-Z |
0.335 |
|
| 2003 |
Wencker D, Chandra M, Nguyen K, Miao W, Garantziotis S, Factor SM, Shirani J, Armstrong RC, Kitsis RN. A mechanistic role for cardiac myocyte apoptosis in heart failure Journal of Clinical Investigation. 111: 1497-1504. PMID 12750399 DOI: 10.1172/Jci17664 |
0.456 |
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| 2003 |
Huang H, Petkova SB, Cohen AW, Bouzahzah B, Chan J, Zhou JN, Factor SM, Weiss LM, Krishnamachary M, Mukherjee S, Wittner M, Kitsis RN, Pestell RG, Lisanti MP, Albanese C, et al. Activation of transcription factors AP-1 and NF-kappa B in murine Chagasic myocarditis. Infection and Immunity. 71: 2859-67. PMID 12704159 DOI: 10.1128/Iai.71.5.2859-2867.2003 |
0.342 |
|
| 2003 |
Mani K, Kitsis RN. Myocyte apoptosis: programming ventricular remodeling. Journal of the American College of Cardiology. 41: 761-4. PMID 12628719 DOI: 10.1016/S0735-1097(02)02958-3 |
0.335 |
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| 2003 |
Lee P, Sata M, Lefer DJ, Factor SM, Walsh K, Kitsis RN. Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo. American Journal of Physiology. Heart and Circulatory Physiology. 284: H456-63. PMID 12414449 DOI: 10.1152/Ajpheart.00777.2002 |
0.654 |
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| 2003 |
Cohen AW, Park DS, Woodman SE, Williams TM, Chandra M, Shirani J, Pereira de Souza A, Kitsis RN, Russell RG, Weiss LM, Tang B, Jelicks LA, Factor SM, Shtutin V, Tanowitz HB, et al. Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts. American Journal of Physiology. Cell Physiology. 284: C457-74. PMID 12388077 DOI: 10.1152/Ajpcell.00380.2002 |
0.36 |
|
| 2002 |
Woodman SE, Park DS, Cohen AW, Cheung MW, Chandra M, Shirani J, Tang B, Jelicks LA, Kitsis RN, Christ GJ, Factor SM, Tanowitz HB, Lisanti MP. Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade. The Journal of Biological Chemistry. 277: 38988-97. PMID 12138167 DOI: 10.1074/Jbc.M205511200 |
0.39 |
|
| 2002 |
Peng CF, Wei Y, Levsky JM, McDonald TV, Childs G, Kitsis RN. Microarray analysis of global changes in gene expression during cardiac myocyte differentiation. Physiological Genomics. 9: 145-55. PMID 12045295 DOI: 10.1152/Physiolgenomics.00027.2002 |
0.367 |
|
| 2002 |
Tarzami ST, Cheng R, Miao W, Kitsis RN, Berman JW. Chemokine expression in myocardial ischemia: MIP-2 dependent MCP-1 expression protects cardiomyocytes from cell death. Journal of Molecular and Cellular Cardiology. 34: 209-21. PMID 11851360 DOI: 10.1006/Jmcc.2001.1503 |
0.421 |
|
| 2001 |
Gottlieb RA, Kitsis RN. Seeing death in the living Nature Medicine. 7: 1277-1278. PMID 11726959 DOI: 10.1038/Nm1201-1277 |
0.385 |
|
| 2001 |
Gao M, Fan S, Goldberg ID, Laterra J, Kitsis RN, Rosen EM. Hepatocyte Growth Factor/Scatter Factor Blocks the Mitochondrial Pathway of Apoptosis Signaling in Breast Cancer Cells Journal of Biological Chemistry. 276: 47257-47265. PMID 11571297 DOI: 10.1074/Jbc.M106791200 |
0.454 |
|
| 2001 |
Martins GA, Petkova SB, Machado FS, Kitsis RN, Weiss LM, Wittner M, Tanowitz HB, Silva JS. Fas-FasL interaction modulates nitric oxide production in Trypanosoma cruzi-infected mice Immunology. 103: 122-129. PMID 11380700 DOI: 10.1046/J.1365-2567.2001.01216.X |
0.342 |
|
| 2001 |
Liu J, Lee P, Galbiati F, Kitsis RN, Lisanti MP. Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation. American Journal of Physiology. Cell Physiology. 280: C823-35. PMID 11245599 DOI: 10.1152/Ajpcell.2001.280.4.C823 |
0.633 |
|
| 2001 |
Kitsis RN. Manipulating apoptosis in the myocardium Journal of Molecular and Cellular Cardiology. 33: A149. DOI: 10.1016/S0022-2828(01)90571-1 |
0.423 |
|
| 2000 |
Miao W, Luo Z, Kitsis RN, Walsh K. Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo Journal of Molecular and Cellular Cardiology. 32: 2397-2402. PMID 11113015 DOI: 10.1006/Jmcc.2000.1283 |
0.336 |
|
| 2000 |
Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, Hewett TE, Jones SP, Lefer DJ, Peng CF, Kitsis RN, Molkentin JD. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. The Embo Journal. 19: 6341-50. PMID 11101507 DOI: 10.1093/Emboj/19.23.6341 |
0.374 |
|
| 2000 |
De Windt LJ, Lim HW, Taigen T, Wencker D, Condorelli G, Dorn GW, Kitsis RN, Molkentin JD. Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo. An apoptosis-independent model of dilated heart failure Circulation Research. 86: 255-263. PMID 10679475 DOI: 10.1161/01.Res.86.3.255 |
0.483 |
|
| 2000 |
Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K. Akt promotes survival of cardiomyocytes in vitro and protects against lschemia-reperfusion injury in mouse heart Circulation. 101: 660-667. PMID 10673259 DOI: 10.1161/01.Cir.101.6.660 |
0.383 |
|
| 1999 |
Albanese C, D'Amico M, Reutens AT, Fu M, Watanabe G, Lee RJ, Kitsis RN, Henglein B, Avantaggiati M, Somasundaram K, Thimmapaya B, Pestell RG. Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis Journal of Biological Chemistry. 274: 34186-34195. PMID 10567390 DOI: 10.1074/Jbc.274.48.34186 |
0.38 |
|
| 1999 |
Bialik S, Cryns VL, Drincic A, Miyata S, Wollowick AL, Srinivasan A, Kitsis RN. The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes Circulation Research. 85: 403-414. PMID 10473670 DOI: 10.1161/01.Res.85.5.403 |
0.473 |
|
| 1999 |
Morimoto T, Hasegawa K, Kaburagi S, Kakita T, Masutani H, Kitsis RN, Matsumori A, Sasayama S. GATA-5 is involved in leukemia inhibitory factor-responsive transcription of the β-myosin heavy chain gene in cardiac myocytes Journal of Biological Chemistry. 274: 12811-12818. PMID 10212267 DOI: 10.1074/Jbc.274.18.12811 |
0.339 |
|
| 1998 |
Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A, Brenner DA, Czaja MJ. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. The American Journal of Physiology. 275: C1058-66. PMID 9755059 DOI: 10.1152/Ajpcell.1998.275.4.C1058 |
0.324 |
|
| 1998 |
Shizukuda Y, Buttrick PM, Geenen DL, Borczuk AC, Kitsis RN, Sonnenblick EH. β-Adrenergic stimulation causes cardiocyte apoptosis: Influence of tachycardia and hypertrophy American Journal of Physiology - Heart and Circulatory Physiology. 275. PMID 9724301 DOI: 10.1152/Ajpheart.1998.275.3.H961 |
0.341 |
|
| 1998 |
Shizukuda Y, Sonnenblick E, Geenen D, Borczuk A, Kitsis R, Buttrick P. Chronic pressure overload is associated with cardiocyte apoptosis, but does not increase vulnerability to β-adrenergic mediated cardiocyte apoptosis Journal of the American College of Cardiology. 31: 176. DOI: 10.1016/S0735-1097(98)81407-1 |
0.375 |
|
| 1998 |
Shizukuda Y, Sonnenblick E, Geenen D, Borczuk A, Kitsis R, Buttrick P. β-Adrenergic stimulation induces cardiocyte apoptosis which is not mediated by an increase in heart rate Journal of the American College of Cardiology. 31: 177. DOI: 10.1016/S0735-1097(97)84474-9 |
0.39 |
|
| 1997 |
Hasegawa K, Lee SJ, Jobe SM, Markham BE, Kitsis RN. cis-Acting sequences that mediate induction of β-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction Circulation. 96: 3943-3953. PMID 9403619 DOI: 10.1161/01.Cir.96.11.3943 |
0.315 |
|
| 1997 |
Bialik S, Geenen DL, Sasson IE, Cheng R, Horner JW, Evans SM, Lord EM, Koch CJ, Kitsis RN. Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53 Journal of Clinical Investigation. 100: 1363-1372. PMID 9294101 DOI: 10.1172/Jci119656 |
0.437 |
|
| 1997 |
Hasegawa K, Meyers MB, Kitsis RN. Transcriptional coactivator p300 stimulates cell type-specific gene expression in cardiac myocytes Journal of Biological Chemistry. 272: 20049-20054. PMID 9242676 DOI: 10.1074/Jbc.272.32.20049 |
0.387 |
|
| 1996 |
Kitsis RN, Scheuer J. Functional significance of alterations in cardiac contractile protein isoforms Clinical Cardiology. 19: 9-18. PMID 8903533 DOI: 10.1002/Clc.4960190105 |
0.335 |
|
| 1996 |
Liu Y, Kitsis RN. Induction of DNA synthesis and apoptosis in cardiac myocytes by E1A oncoprotein Journal of Cell Biology. 133: 325-334. PMID 8609165 DOI: 10.1083/Jcb.133.2.325 |
0.384 |
|
| 1993 |
Buttrick PM, Kaplan ML, Kitsis RN, Leinwand LA. Distinct behavior of cardiac myosin heavy chain gene constructs in vivo: Discordance with in vitro results Circulation Research. 72: 1211-1217. PMID 8495550 DOI: 10.1161/01.Res.72.6.1211 |
0.301 |
|
| 1991 |
Kitsis RN, Buttrick PM, Mcnally EM, Kaplan ML, Leinwand LA. Hormonal modulation of a gene injected into rat heart in vivo Proceedings of the National Academy of Sciences of the United States of America. 88: 4138-4142. PMID 2034660 DOI: 10.1073/Pnas.88.10.4138 |
0.303 |
|
| 1990 |
Buttrick PM, Kass A, Kitsis RN, Kaplan ML, Leinwand LA. Behavior of genes directly injected into the rat heart in vivo Circulation Research. 70: 193-198. PMID 1309314 DOI: 10.1161/01.Res.70.1.193 |
0.31 |
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