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Kent L. Rossman, Ph.D. - Publications

Affiliations: 
2002 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Biochemistry
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Lawson CD, Fan C, Mitin N, Baker NM, George SD, Graham DM, Perou CM, Burridge K, Der CJ, Rossman KL. Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-activating Proteins in Basal-like Breast Cancers. Cancer Research. PMID 27216196 DOI: 10.1158/0008-5472.Can-15-2923  0.323
2016 Hobbs GA, Der CJ, Rossman KL. RAS isoforms and mutations in cancer at a glance. Journal of Cell Science. PMID 26985062 DOI: 10.1242/Jcs.182873  0.303
2015 Kim TY, Siesser PF, Rossman KL, Goldfarb D, Mackinnon K, Yan F, Yi X, MacCoss MJ, Moon RT, Der CJ, Major MB. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. Molecular and Cellular Biology. 35: 167-81. PMID 25332235 DOI: 10.1128/Mcb.00857-14  0.342
2014 Damoulakis G, Gambardella L, Rossman KL, Lawson CD, Anderson KE, Fukui Y, Welch HC, Der CJ, Stephens LR, Hawkins PT. P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils. Journal of Cell Science. 127: 2589-600. PMID 24659802 DOI: 10.1242/Jcs.153049  0.371
2014 Cook DR, Rossman KL, Der CJ. Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene. 33: 4021-35. PMID 24037532 DOI: 10.1038/Onc.2013.362  0.463
2013 Mitin N, Rossman KL, Currin R, Anne S, Marshall TW, Bear JE, Bautch VL, Der CJ. The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility. Plos One. 8: e66260. PMID 23825001 DOI: 10.1371/Journal.Pone.0066260  0.331
2012 Mitin N, Rossman KL, Der CJ. Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4. Plos One. 7: e41876. PMID 22911862 DOI: 10.1371/Journal.Pone.0041876  0.548
2012 Neel NF, Rossman KL, Martin TD, Hayes TK, Yeh JJ, Der CJ. The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effector. Molecular and Cellular Biology. 32: 1374-86. PMID 22331470 DOI: 10.1128/Mcb.06291-11  0.394
2011 Justilien V, Jameison L, Der CJ, Rossman KL, Fields AP. Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation. The Journal of Biological Chemistry. 286: 8149-57. PMID 21189248 DOI: 10.1074/Jbc.M110.196113  0.387
2010 Vigil D, Cherfils J, Rossman KL, Der CJ. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nature Reviews. Cancer. 10: 842-57. PMID 21102635 DOI: 10.1038/Nrc2960  0.368
2008 Yohe ME, Rossman K, Sondek J. Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins. Biochemistry. 47: 6827-39. PMID 18537266 DOI: 10.1021/Bi702543P  0.796
2007 Mitin N, Betts L, Yohe ME, Der CJ, Sondek J, Rossman KL. Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. Nature Structural & Molecular Biology. 14: 814-23. PMID 17704816 DOI: 10.1038/Nsmb1290  0.774
2007 Yohe ME, Rossman KL, Gardner OS, Karnoub AE, Snyder JT, Gershburg S, Graves LM, Der CJ, Sondek J. Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif. The Journal of Biological Chemistry. 282: 13813-23. PMID 17337446 DOI: 10.1074/Jbc.M700185200  0.791
2006 Baumeister MA, Rossman KL, Sondek J, Lemmon MA. The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity. The Biochemical Journal. 400: 563-72. PMID 17007612 DOI: 10.1042/Bj20061020  0.74
2005 Mitin N, Rossman KL, Der CJ. Signaling interplay in Ras superfamily function. Current Biology : Cb. 15: R563-74. PMID 16051167 DOI: 10.1016/J.Cub.2005.07.010  0.36
2005 Rossman KL, Sondek J. Larger than Dbl: new structural insights into RhoA activation. Trends in Biochemical Sciences. 30: 163-5. PMID 15817389 DOI: 10.1016/J.Tibs.2005.02.002  0.757
2005 Lu M, Kinchen JM, Rossman KL, Grimsley C, Hall M, Sondek J, Hengartner MO, Yajnik V, Ravichandran KS. A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs. Current Biology : Cb. 15: 371-7. PMID 15723800 DOI: 10.1016/J.Cub.2005.01.050  0.748
2005 Rossman KL, Der CJ, Sondek J. GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nature Reviews. Molecular Cell Biology. 6: 167-80. PMID 15688002 DOI: 10.1038/Nrm1587  0.656
2004 Worthylake DK, Rossman KL, Sondek J. Crystal structure of the DH/PH fragment of Dbs without bound GTPase. Structure (London, England : 1993). 12: 1078-86. PMID 15274927 DOI: 10.1016/J.Str.2004.03.021  0.724
2004 Lu M, Kinchen JM, Rossman KL, Grimsley C, deBakker C, Brugnera E, Tosello-Trampont AC, Haney LB, Klingele D, Sondek J, Hengartner MO, Ravichandran KS. PH domain of ELMO functions in trans to regulate Rac activation via Dock180. Nature Structural & Molecular Biology. 11: 756-62. PMID 15247908 DOI: 10.1038/Nsmb800  0.751
2004 Solski PA, Wilder RS, Rossman KL, Sondek J, Cox AD, Campbell SL, Der CJ. Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation. The Journal of Biological Chemistry. 279: 25226-33. PMID 15073184 DOI: 10.1074/Jbc.M313792200  0.735
2003 Salazar MA, Kwiatkowski AV, Pellegrini L, Cestra G, Butler MH, Rossman KL, Serna DM, Sondek J, Gertler FB, De Camilli P. Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. The Journal of Biological Chemistry. 278: 49031-43. PMID 14506234 DOI: 10.1074/Jbc.M308104200  0.711
2003 Rojas RJ, Kimple RJ, Rossman KL, Siderovski DP, Sondek J. Established and emerging fluorescence-based assays for G-protein function: Ras-superfamily GTPases. Combinatorial Chemistry & High Throughput Screening. 6: 409-18. PMID 12769685 DOI: 10.2174/138620703106298509  0.683
2003 Rossman KL, Cheng L, Mahon GM, Rojas RJ, Snyder JT, Whitehead IP, Sondek J. Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation. The Journal of Biological Chemistry. 278: 18393-400. PMID 12637522 DOI: 10.1074/Jbc.M300127200  0.789
2003 Baumeister MA, Martinu L, Rossman KL, Sondek J, Lemmon MA, Chou MM. Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting. The Journal of Biological Chemistry. 278: 11457-64. PMID 12525493 DOI: 10.1074/Jbc.M211901200  0.751
2003 Snyder JT, Rossman KL, Worthylake DK, Sondek J. Structural features of RhoGEFs Handbook of Cell Signaling. 2: 751-755. DOI: 10.1016/B978-012124546-7/50607-0  0.511
2002 Rossman KL, Worthylake DK, Snyder JT, Cheng L, Whitehead IP, Sondek J. Functional analysis of cdc42 residues required for Guanine nucleotide exchange. The Journal of Biological Chemistry. 277: 50893-8. PMID 12401782 DOI: 10.1074/Jbc.M208580200  0.652
2002 Cheng L, Rossman KL, Mahon GM, Worthylake DK, Korus M, Sondek J, Whitehead IP. RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity. Molecular and Cellular Biology. 22: 6895-905. PMID 12215546 DOI: 10.1128/Mcb.22.19.6895-6905.2002  0.615
2002 Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J. Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nature Structural Biology. 9: 468-75. PMID 12006984 DOI: 10.1038/Nsb796  0.718
2002 Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J. A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. The Embo Journal. 21: 1315-26. PMID 11889037 DOI: 10.1093/Emboj/21.6.1315  0.751
2001 Karnoub AE, Worthylake DK, Rossman KL, Pruitt WM, Campbell SL, Sondek J, Der CJ. Molecular basis for Rac1 recognition by guanine nucleotide exchange factors. Nature Structural Biology. 8: 1037-41. PMID 11685227 DOI: 10.1038/Nsb719  0.742
2001 Snyder JT, Rossman KL, Baumeister MA, Pruitt WM, Siderovski DP, Der CJ, Lemmon MA, Sondek J. Quantitative analysis of the effect of phosphoinositide interactions on the function of Dbl family proteins. The Journal of Biological Chemistry. 276: 45868-75. PMID 11577097 DOI: 10.1074/Jbc.M106731200  0.743
2000 Worthylake DK, Rossman KL, Sondek J. Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1 Nature. 408: 682-688. PMID 11130063 DOI: 10.1038/35047014  0.744
2000 Rossman KL, Campbell SL. Bacterial expressed DH and DH/PH domains. Methods in Enzymology. 325: 25-38. PMID 11036589 DOI: 10.1016/S0076-6879(00)25428-1  0.612
2000 Abe K, Rossman KL, Liu B, Ritola KD, Chiang D, Campbell SL, Burridge K, Der CJ. Vav2 is an activator of Cdc42, Rac1, and RhoA. The Journal of Biological Chemistry. 275: 10141-9. PMID 10744696 DOI: 10.1074/Jbc.275.14.10141  0.495
1999 Whitehead IP, Lambert QT, Glaven JA, Abe K, Rossman KL, Mahon GM, Trzaskos JM, Kay R, Campbell SL, Der CJ. Dependence of Dbl and Dbs transformation on MEK and NF-κB activation Molecular and Cellular Biology. 19: 7759-7770. PMID 10523665 DOI: 10.1128/Mcb.19.11.7759  0.52
1998 Zohn IM, Campbell SL, Khosravi-Far R, Rossman KL, Der CJ. Rho family proteins and Ras transformation: The RHOad less traveled gets congested Oncogene. 17: 1415-1438. PMID 9779988 DOI: 10.1038/Sj.Onc.1202181  0.443
1998 Campbell SL, Khosravi-Far R, Rossman KL, Clark GJ, Der CJ. Increasing complexity of Ras signaling Oncogene. 17: 1395-1413. PMID 9779987 DOI: 10.1038/Sj.Onc.1202174  0.342
1997 Khosravi-Far R, Campbell S, Rossman KL, Der CJ. Increasing complexity of ras signal transduction: Involvement of rho family proteins Advances in Cancer Research. 72: 57-107. PMID 9338074 DOI: 10.1016/S0065-230X(08)60700-9  0.369
1997 Clark GJ, Drugan JK, Rossman KL, Carpenter JW, Rogers-Graham K, Fu H, Der CJ, Campbell SL. 14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain. The Journal of Biological Chemistry. 272: 20990-3. PMID 9261098 DOI: 10.1074/Jbc.272.34.20990  0.545
1997 Whitehead IP, Campbell S, Rossman KL, Der CJ. Dbl family proteins Biochimica Et Biophysica Acta - Reviews On Cancer. 1332: F1-F23. PMID 9061011 DOI: 10.1016/S0304-419X(96)00040-6  0.385
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