| Year |
Citation |
Score |
| 2013 |
Trammel AM, Simmons JE, Borchardt RT. An efficient in vitro assay for acetylcholinesterase reactivators using immobilized enzyme. Pharmaceutical Research. 1: 115-20. PMID 24277247 DOI: 10.1023/A:1016323919445 |
0.32 |
|
| 2012 |
Nofsinger R, Fuchs-Knotts T, Borchardt RT. Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 3: Synthesis of analogs designed to have improved stability to oxidative metabolism. Journal of Pharmaceutical Sciences. 101: 3486-99. PMID 22411763 DOI: 10.1002/Jps.23109 |
0.782 |
|
| 2012 |
Nofsinger R, Borchardt RT. Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 4: Characterization of the biopharmaceutical and physicochemical properties of two new cyclic prodrugs designed to be stable to oxidative metabolism by cytochrome P-450 enzymes in the intestinal mucosa. Journal of Pharmaceutical Sciences. 101: 3500-10. PMID 22337204 DOI: 10.1002/Jps.23079 |
0.791 |
|
| 2012 |
Wang B, Shan D, Wang W, Zhang H, Gudmundsson O, Borchardt RT. Synthesis of coumarin-based, esterase-sensitive cyclic prodrugs of opioid peptides with enhanced membrane permeability and enzymatic stability. Methods in Molecular Medicine. 23: 71-85. PMID 21380892 DOI: 10.1385/0-89603-517-4:71 |
0.536 |
|
| 2012 |
Wang B, Gangwar S, Pauletti G, Siahaan T, Borchardt RT. Synthesis of an esterase-sensitive cyclic prodrug of a model hexapeptide having enhanced membrane permeability and enzymatic stability using a 3-(2'-hydroxy-4',6'-dimethylphenyl)-3,3-dimethyl propionic Acid promoiety. Methods in Molecular Medicine. 23: 53-69. PMID 21380891 DOI: 10.1385/0-89603-517-4:53 |
0.551 |
|
| 2012 |
Gangwar S, Pauletti GM, Siahaan TJ, Stella VJ, Borchardt RT. Synthesis of an esterase-sensitive cyclic prodrug of a model hexapeptide having enhanced membrane permeability and enzymatic stability using an acyloxyalkoxy promoiety. Methods in Molecular Medicine. 23: 37-51. PMID 21380890 DOI: 10.1385/0-89603-517-4:37 |
0.382 |
|
| 2010 |
Mudra DR, Jin JY, Borchardt RT. Absorption barriers in the rat intestinal mucosa: 2. Application of physiologically based mathematical models to quantify mechanisms of drug permeation and metabolism. Journal of Pharmaceutical Sciences. 99: 999-1015. PMID 19798765 DOI: 10.1002/Jps.21965 |
0.746 |
|
| 2010 |
Mudra DR, Borchardt RT. Absorption barriers in the rat intestinal mucosa: 1. Application of an in situ perfusion model to simultaneously assess drug permeation and metabolism. Journal of Pharmaceutical Sciences. 99: 982-98. PMID 19746412 DOI: 10.1002/Jps.21912 |
0.751 |
|
| 2010 |
Mudra DR, Borchardt RT. Absorption barriers in the rat intestinal mucosa. 3: Effects of polyethoxylated solubilizing agents on drug permeation and metabolism. Journal of Pharmaceutical Sciences. 99: 1016-27. PMID 19650119 DOI: 10.1002/Jps.21836 |
0.746 |
|
| 2010 |
Wang B, Gangwar S, Pauletti G, Siahaan T, Borchardt RT. ChemInform Abstract: Synthesis of an Esterase-Sensitive Cyclic Prodrug of a Model Hexapeptide Having Enhanced Membrane Permeability and Enzymic Stability Using a 3-(2′-Hydroxy-4′,6′-dimethylphenyl)-3,3-Dimethylpropionic Acid Promoiety Cheminform. 31: no-no. DOI: 10.1002/chin.200032252 |
0.448 |
|
| 2010 |
Wang B, Shan D, Wang W, Zhang H, Gudmundsson O, Borchardt RT. ChemInform Abstract: Synthesis of Coumarin-Based, Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides with Enhanced Membrane Permeability and Enzymic Stability Cheminform. 31: no-no. DOI: 10.1002/CHIN.200032251 |
0.455 |
|
| 2010 |
Wang B, Wang W, Camenisch GP, Elmo J, Zhang H, Borchardt RT. ChemInform Abstract: Synthesis and Evaluation of Novel Coumarin-Based Esterase-Sensitive Cyclic Prodrugs of Peptidomimetic RGD Analogues with Improved Membrane Permeability. Cheminform. 30: no-no. DOI: 10.1002/chin.199930175 |
0.418 |
|
| 2010 |
WANG B, LIU S, BORCHARDT RT. ChemInform Abstract: Development of a Novel Redox-Sensitive Protecting Group for Amines Which Utilizes a Facilitated Lactonization Reaction. Cheminform. 26: no-no. DOI: 10.1002/chin.199529091 |
0.396 |
|
| 2009 |
Li QS, Cai S, Fang J, Borchardt RT, Kuczera K, Middaugh CR, Schowen RL. Evaluation of NAD(H) analogues as selective inhibitors for Trypanosoma cruzi S-adenosylhomocysteine hydrolase. Nucleosides, Nucleotides & Nucleic Acids. 28: 473-84. PMID 20183597 DOI: 10.1080/15257770903044572 |
0.314 |
|
| 2009 |
Ouyang H, Andersen TE, Chen W, Nofsinger R, Steffansen B, Borchardt RT. A comparison of the effects of p-glycoprotein inhibitors on the blood-brain barrier permeation of cyclic prodrugs of an opioid peptide (DADLE). Journal of Pharmaceutical Sciences. 98: 2227-36. PMID 18855917 DOI: 10.1002/Jps.21585 |
0.785 |
|
| 2009 |
Ouyang H, Chen W, Andersen TE, Steffansen B, Borchardt RT. Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa. Journal of Pharmaceutical Sciences. 98: 349-61. PMID 18537150 DOI: 10.1002/Jps.21424 |
0.381 |
|
| 2009 |
Ouyang H, Chen W, Andersen TE, Steffansen B, Borchardt RT. Factors that restrict the intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part I. Role of efflux transporters in the intestinal mucosa. Journal of Pharmaceutical Sciences. 98: 337-48. PMID 18537149 DOI: 10.1002/Jps.21428 |
0.359 |
|
| 2008 |
Li QS, Cai S, Fang J, Borchardt RT, Kuczera K, Middaugh CR, Schowen RL. Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix 18 stability. Biochemistry. 47: 4983-91. PMID 18393535 DOI: 10.1021/Bi800175G |
0.308 |
|
| 2007 |
Cai S, Li QS, Borchardt RT, Kuczera K, Schowen RL. The antiviral drug ribavirin is a selective inhibitor of S-adenosyl-L-homocysteine hydrolase from Trypanosoma cruzi. Bioorganic & Medicinal Chemistry. 15: 7281-7. PMID 17845853 DOI: 10.1016/J.Bmc.2007.08.029 |
0.307 |
|
| 2007 |
Li QS, Cai S, Borchardt RT, Fang J, Kuczera K, Middaugh CR, Schowen RL. Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 1. Basic features of the association and dissociation processes. Biochemistry. 46: 5798-809. PMID 17447732 DOI: 10.1021/Bi700170M |
0.306 |
|
| 2007 |
Wakankar AA, Liu J, Vandervelde D, Wang YJ, Shire SJ, Borchardt RT. The effect of cosolutes on the isomerization of aspartic acid residues and conformational stability in a monoclonal antibody. Journal of Pharmaceutical Sciences. 96: 1708-18. PMID 17238195 DOI: 10.1002/Jps.20823 |
0.306 |
|
| 2006 |
Liederer BM, Borchardt RT. Enzymes involved in the bioconversion of ester-based prodrugs. Journal of Pharmaceutical Sciences. 95: 1177-95. PMID 16639719 DOI: 10.1002/Jps.20542 |
0.644 |
|
| 2006 |
Liederer BM, Fuchs T, Vander Velde D, Siahaan TJ, Borchardt RT. Effects of amino acid chirality and the chemical linker on the cell permeation characteristics of cyclic prodrugs of opioid peptides. Journal of Medicinal Chemistry. 49: 1261-70. PMID 16480263 DOI: 10.1021/Jm050277F |
0.682 |
|
| 2005 |
Liederer BM, Phan KT, Ouyang H, Borchardt RT. Significant differences in the disposition of cyclic prodrugs of opioid peptides in rats and guinea pigs following IV administration. Journal of Pharmaceutical Sciences. 94: 2676-87. PMID 16258984 DOI: 10.1002/Jps.20476 |
0.676 |
|
| 2005 |
Liederer BM, Borchardt RT. Stability of oxymethyl-modified coumarinic acid cyclic prodrugs of diastereomeric opioid peptides in biological media from various animal species including human. Journal of Pharmaceutical Sciences. 94: 2198-206. PMID 16136552 DOI: 10.1002/Jps.20452 |
0.681 |
|
| 2005 |
Li B, O'Meara MH, Lubach JW, Schowen RL, Topp EM, Munson EJ, Borchardt RT. Effects of sucrose and mannitol on asparagine deamidation rates of model peptides in solution and in the solid state. Journal of Pharmaceutical Sciences. 94: 1723-35. PMID 15986465 DOI: 10.1002/Jps.20372 |
0.308 |
|
| 2004 |
Tang F, Ouyang H, Yang JZ, Borchardt RT. Bidirectional transport of rhodamine 123 and Hoechst 33342, fluorescence probes of the binding sites on P-glycoprotein, across MDCK-MDR1 cell monolayers. Journal of Pharmaceutical Sciences. 93: 1185-94. PMID 15067695 DOI: 10.1002/Jps.20046 |
0.328 |
|
| 2003 |
Parker NB, Yang X, Hanke J, Mason KA, Schowen RL, Borchardt RT, Yin DH. Trypanosoma cruzi: molecular cloning and characterization of the S-adenosylhomocysteine hydrolase. Experimental Parasitology. 105: 149-58. PMID 14969692 DOI: 10.1016/J.Exppara.2003.10.001 |
0.305 |
|
| 2003 |
Li B, Borchardt RT, Topp EM, VanderVelde D, Schowen RL. Racemization of an asparagine residue during peptide deamidation. Journal of the American Chemical Society. 125: 11486-7. PMID 13129337 DOI: 10.1021/Ja0360992 |
0.321 |
|
| 2003 |
Johnson BM, Chen W, Borchardt RT, Charman WN, Porter CJ. A kinetic evaluation of the absorption, efflux, and metabolism of verapamil in the autoperfused rat jejunum. The Journal of Pharmacology and Experimental Therapeutics. 305: 151-8. PMID 12649363 DOI: 10.1124/Jpet.102.045328 |
0.335 |
|
| 2003 |
Yang X, Hu Y, Yin DH, Turner MA, Wang M, Borchardt RT, Howell PL, Kuczera K, Schowen RL. Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions. Biochemistry. 42: 1900-9. PMID 12590576 DOI: 10.1021/Bi0262350 |
0.328 |
|
| 2003 |
D'Souza AJ, Schowen RL, Borchardt RT, Salsbury JS, Munson EJ, Topp EM. Reaction of a peptide with polyvinylpyrrolidone in the solid state. Journal of Pharmaceutical Sciences. 92: 585-93. PMID 12587120 DOI: 10.1002/Jps.10316 |
0.323 |
|
| 2003 |
Hugger ED, Cole CJ, Raub TJ, Burton PS, Borchardt RT. Automated analysis of polyethylene glycol-induced inhibition of P-glycoprotein activity in vitro. Journal of Pharmaceutical Sciences. 92: 21-6. PMID 12486678 DOI: 10.1002/Jps.10265 |
0.784 |
|
| 2002 |
Chen W, Yang JZ, Andersen R, Nielsen LH, Borchardt RT. Evaluation of the permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs across the blood-brain barrier using an in situ perfused rat brain model. The Journal of Pharmacology and Experimental Therapeutics. 303: 849-57. PMID 12388672 DOI: 10.1124/Jpet.102.037143 |
0.356 |
|
| 2002 |
Yang JZ, Chen W, Borchardt RT. In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs. The Journal of Pharmacology and Experimental Therapeutics. 303: 840-8. PMID 12388671 DOI: 10.1124/Jpet.102.037135 |
0.385 |
|
| 2002 |
Hugger ED, Novak BL, Burton PS, Audus KL, Borchardt RT. A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro. Journal of Pharmaceutical Sciences. 91: 1991-2002. PMID 12210046 DOI: 10.1002/Jps.10176 |
0.778 |
|
| 2002 |
Hugger ED, Audus KL, Borchardt RT. Effects of poly(ethylene glycol) on efflux transporter activity in Caco-2 cell monolayers. Journal of Pharmaceutical Sciences. 91: 1980-90. PMID 12210045 DOI: 10.1002/Jps.10175 |
0.787 |
|
| 2002 |
Ouyang H, Tang F, Siahaan TJ, Borchardt RT. A modified coumarinic acid-based cyclic prodrug of an opioid peptide: its enzymatic and chemical stability and cell permeation characteristics. Pharmaceutical Research. 19: 794-801. PMID 12134949 DOI: 10.1023/A:1016148631055 |
0.353 |
|
| 2002 |
Tang F, Borchardt RT. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE. Pharmaceutical Research. 19: 787-93. PMID 12134948 DOI: 10.1023/A:1016196514217 |
0.336 |
|
| 2002 |
Tang F, Borchardt RT. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of an acyloxyalkoxy-based cyclic prodrug of the opioid peptide DADLE. Pharmaceutical Research. 19: 780-6. PMID 12134947 DOI: 10.1023/A:1016144530146 |
0.323 |
|
| 2002 |
Friedrichsen GM, Chen W, Begtrup M, Lee CP, Smith PL, Borchardt RT. Synthesis of analogs of L-valacyclovir and determination of their substrate activity for the oligopeptide transporter in Caco-2 cells. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 16: 1-13. PMID 12113886 DOI: 10.1016/S0928-0987(02)00047-7 |
0.354 |
|
| 2002 |
Ouyang H, Borchardt RT, Siahaan TJ, Vander Velde DG. Synthesis and conformational analysis of a coumarinic acid-based cyclic prodrug of an opioid peptide with modified sensitivity to esterase-catalyzed bioconversion Journal of Peptide Research. 59: 183-195. PMID 11972752 DOI: 10.1034/J.1399-3011.2002.1O983.X |
0.348 |
|
| 2001 |
Gao J, Hugger ED, Beck-Westermeyer MS, Borchardt RT. Estimating intestinal mucosal permeation of compounds using Caco-2 cell monolayers. Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. Unit 7.2. PMID 22293966 DOI: 10.1002/0471141755.Ph0702S08 |
0.769 |
|
| 2001 |
Hu Y, Yang X, Yin DH, Mahadevan J, Kuczera K, Schowen RL, Borchardt RT. Computational characterization of substrate binding and catalysis in S-adenosylhomocysteine hydrolase. Biochemistry. 40: 15143-52. PMID 11735397 DOI: 10.1021/Bi015690D |
0.331 |
|
| 2001 |
Song Y, Schowen RL, Borchardt RT, Topp EM. Formaldehyde production by Tris buffer in peptide formulations at elevated temperature. Journal of Pharmaceutical Sciences. 90: 1198-203. PMID 11536224 DOI: 10.1002/Jps.1073 |
0.308 |
|
| 2001 |
Gao J, Murase O, Schowen RL, Aubé J, Borchardt RT. A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharmaceutical Research. 18: 171-6. PMID 11405287 DOI: 10.1023/A:1011076217118 |
0.625 |
|
| 2001 |
Gao J, Winslow SL, Vander Velde D, Aubé J, Borchardt RT. Transport characteristics of peptides and peptidomimetics: II. Hydroxyethylamine bioisostere-containing peptidomimetics as substrates for the oligopeptide transporter and P-glycoprotein in the intestinal mucosa. The Journal of Peptide Research : Official Journal of the American Peptide Society. 57: 361-73. PMID 11350596 DOI: 10.1034/J.1399-3011.2001.00830.X |
0.657 |
|
| 2001 |
Gao J, Sudoh M, Aubé J, Borchardt RT. Transport characteristics of peptides and peptidomimetics: I. N-methylated peptides as substrates for the oligopeptide transporter and P-glycoprotein in the intestinal mucosa. The Journal of Peptide Research : Official Journal of the American Peptide Society. 57: 316-29. PMID 11328489 DOI: 10.1046/J.1397-002X.2001.00000.X |
0.643 |
|
| 2001 |
Yang X, Borchardt RT. Overexpression, purification, and characterization of S-adenosylhomocysteine hydrolase from Leishmania donovani. Archives of Biochemistry and Biophysics. 383: 272-80. PMID 11185563 DOI: 10.1006/Abbi.2000.2087 |
0.306 |
|
| 2001 |
Khossravi M, Borchardt RT. Chemical pathways of peptide degradation. X: effect of metal-catalyzed oxidation on the solution structure of a histidine-containing peptide fragment of human relaxin. Pharmaceutical Research. 17: 851-8. PMID 10990205 DOI: 10.1023/A:1007564410491 |
0.302 |
|
| 2000 |
Turner MA, Yang X, Yin D, Kuczera K, Borchardt RT, Howell PL. Structure and function of S-adenosylhomocysteine hydrolase. Cell Biochemistry and Biophysics. 33: 101-25. PMID 11325033 DOI: 10.1385/Cbb:33:2:101 |
0.306 |
|
| 2000 |
Yang X, Yin D, Wnuk SF, Robins MJ, Borchardt RT. Mechanisms of inactivation of human S-adenosylhomocysteine hydrolase by 5',5',6',6'-tetradehydro-6'-deoxy-6'-halohomoadenosines. Biochemistry. 39: 15234-41. PMID 11106503 DOI: 10.1021/Bi0015055 |
0.323 |
|
| 2000 |
Goolcharran C, Stauffer LL, Cleland JL, Borchardt RT. The effects of a histidine residue on the C-terminal side of an asparaginyl residue on the rate of deamidation using model pentapeptides. Journal of Pharmaceutical Sciences. 89: 818-25. PMID 10824141 DOI: 10.1002/(Sici)1520-6017(200006)89:6<818::Aid-Jps14>3.0.Co;2-8 |
0.321 |
|
| 2000 |
Wnuk SF, Valdez CA, Khan J, Moutinho P, Robins MJ, Yang X, Borchardt RT, Balzarini J, De Clercq E. Doubly homologated dihalovinyl and acetylene analogues of adenosine: synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects. Journal of Medicinal Chemistry. 43: 1180-6. PMID 10737751 DOI: 10.1021/Jm990486Y |
0.324 |
|
| 2000 |
Shan D, Zheng A, Ballard CE, Wang W, Borchardt RT, Wang B. A facilitated cyclic ether formation and its potential application in solid-phase peptide and organic synthesis. Chemical & Pharmaceutical Bulletin. 48: 238-44. PMID 10705512 DOI: 10.1248/Cpb.48.238 |
0.713 |
|
| 2000 |
Wang W, Borchardt RT, Wang B. Orally active peptidomimetic RGD analogs that are glycoprotein IIb/IIIa antagonists. Current Medicinal Chemistry. 7: 437-53. PMID 10702618 DOI: 10.2174/0929867003375074 |
0.543 |
|
| 2000 |
Wang W, Camenisch G, Sane DC, Zhang H, Hugger E, Wheeler GL, Borchardt RT, Wang B. A coumarin-based prodrug strategy to improve the oral absorption of RGD peptidomimetics. Journal of Controlled Release : Official Journal of the Controlled Release Society. 65: 245-51. PMID 10699284 DOI: 10.1016/S0168-3659(99)00241-2 |
0.785 |
|
| 1999 |
Borchardt RT. Optimizing oral absorption of peptides using prodrug strategies. Journal of Controlled Release : Official Journal of the Controlled Release Society. 62: 231-8. PMID 10518655 DOI: 10.1016/S0168-3659(99)00042-5 |
0.39 |
|
| 1999 |
Gudmundsson OS, Vander Velde DG, Jois SDS, Bak A, Siahaan TJ, Borchardt RT. The effect of conformation of the acyloxyalkoxy-based cyclic prodrugs of opioid peptides on their membrane permeability Journal of Peptide Research. 53: 403-413. PMID 10406218 DOI: 10.1034/J.1399-3011.1999.00077.X |
0.344 |
|
| 1999 |
Bak A, Siahaan TJ, Gudmundsson OS, Gangwar S, Friis GJ, Borchardt RT. Synthesis and evaluation of the physicochemical properties of esterase- sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker Journal of Peptide Research. 53: 393-402. PMID 10406217 DOI: 10.1034/J.1399-3011.1999.00070.X |
0.345 |
|
| 1999 |
Gudmundsson OS, Jois SDS, Vander Velde DG, Siahaan TJ, Wang B, Borchardt RT. The effect of conformation on the membrane permeation of coumarinic acid- and phenylpropionic acid-based cyclic prodrugs of opioid peptides Journal of Peptide Research. 53: 383-392. PMID 10406216 DOI: 10.1034/J.1399-3011.1999.00076.X |
0.538 |
|
| 1999 |
Wang B, Nimkar K, Wang W, Zhang H, Shan D, Gudmundsson O, Gangwar S, Siahaan T, Borchardt RT. Synthesis and evaluation of the physicochemical properties of esterase- sensitive cyclic prodrugs of opioid peptides using coumarinic acid and phenylpropionic acid linkers Journal of Peptide Research. 53: 370-382. PMID 10406215 DOI: 10.1034/J.1399-3011.1999.00071.X |
0.56 |
|
| 1999 |
Wang B, Wang W, Camenisch GP, Elmo J, Zhang H, Borchardt RT. Synthesis and evaluation of novel coumarin-based esterase-sensitive cyclic prodrugs of peptidomimetic RGD analogs with improved membrane permeability. Chemical & Pharmaceutical Bulletin. 47: 90-5. PMID 9987829 DOI: 10.1248/Cpb.47.90 |
0.491 |
|
| 1999 |
Bak A, Gudmundsson OS, Friis GJ, Siahaan TJ, Borchardt RT. Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: Evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers Pharmaceutical Research. 16: 24-29. PMID 9950274 DOI: 10.1023/A:1018854308829 |
0.397 |
|
| 1999 |
Gudmundsson OS, Nimkar K, Gangwar S, Siahaan T, Borchardt RT. Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation Pharmaceutical Research. 16: 16-23. PMID 9950273 DOI: 10.1023/A:1018802324759 |
0.335 |
|
| 1999 |
Gudmundsson OS, Pauletti GM, Wang W, Shan D, Zhang H, Wang B, Borchardt RT. Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability Pharmaceutical Research. 16: 7-15. PMID 9950272 DOI: 10.1023/A:1018828207920 |
0.58 |
|
| 1999 |
Yuan CS, Saso Y, Lazarides E, Borchardt RT, Robins MJ. Recent advances in S-adenosyl-L-homocysteine hydrolase inhibitors and their potential clinical applications Expert Opinion On Therapeutic Patents. 9: 1197-1206. DOI: 10.1517/13543776.9.9.1197 |
0.312 |
|
| 1998 |
Li J, Tamura K, Lee CP, Smith PL, Borchardt RT, Hidalgo IJ. Structure-affinity relationships of Val-Val and Val-Val-Val stereoisomers with the apical oligopeptide transporter in human intestinal Caco-2 cells. Journal of Drug Targeting. 5: 317-27. PMID 9771614 DOI: 10.3109/10611869808997860 |
0.302 |
|
| 1998 |
Robins MJ, Wnuk SF, Yang X, Yuan CS, Borchardt RT, Balzarini J, De Clercq E. Inactivation of S-adenosyl-L-homocysteine hydrolase and antiviral activity with 5',5',6',6'-tetradehydro-6'-deoxy-6'-halohomoadenosine analogues (4'-haloacetylene analogues derived from adenosine). Journal of Medicinal Chemistry. 41: 3857-64. PMID 9748360 DOI: 10.1021/Jm980163M |
0.317 |
|
| 1998 |
Wnuk SF, Yuan CS, Borchardt RT, Robins MJ. Synthesis of homologated halovinyl derivatives from aristeromycin and their inhibition of human placental S-adenosyl-L-homocysteine hydrolase. Nucleosides & Nucleotides. 17: 99-113. PMID 9708344 DOI: 10.1080/07328319808005161 |
0.304 |
|
| 1998 |
Camenisch GP, Wang W, Wang B, Borchardt RT. A comparison of the bioconversion rates and the Caco-2 cell permeation characteristics of coumarin-based cyclic prodrugs and methylester-based linear prodrugs of RGD peptidomimetics. Pharmaceutical Research. 15: 1174-81. PMID 9706046 DOI: 10.1023/A:1011975404789 |
0.481 |
|
| 1998 |
Wnuk SF, Mao Y, Yuan CS, Borchardt RT, Andrei G, Balzarini J, De Clercq E, Robins MJ. Discovery of type II (covalent) inactivation of S-adenosyl-L-homocysteine hydrolase involving its "hydrolytic activity": synthesis and evaluation of dihalohomovinyl nucleoside analogues derived from adenosine. Journal of Medicinal Chemistry. 41: 3078-83. PMID 9685247 DOI: 10.1021/Jm9801410 |
0.347 |
|
| 1998 |
Yuan CS, Wnuk SF, Robins MJ, Borchardt RT. A novel mechanism-based inhibitor (6'-bromo-5', 6'-didehydro-6'-deoxy-6'-fluorohomoadenosine) that covalently modifies human placental S-adenosylhomocysteine hydrolase. The Journal of Biological Chemistry. 273: 18191-7. PMID 9660780 DOI: 10.1074/Jbc.273.29.18191 |
0.317 |
|
| 1998 |
Sudoh M, Pauletti GM, Yao W, Moser W, Yokoyama A, Pasternak A, Sprengeler PA, Smith AB, Hirschmann R, Borchardt RT. Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers Pharmaceutical Research. 15: 719-725. PMID 9619780 DOI: 10.1023/A:1011966918959 |
0.357 |
|
| 1998 |
Robins MJ, Neschadimenko V, Ro B, Yuan C, Borchardt RT, Wnuk SF. Nucleic Acid Related Compounds. 101.S-Adenosyl-l-homocysteine Hydrolase Does Not Hydrate (5‘-Fluoro)vinyl or (6‘-Halo)homovinyl Analogues Derived from 3‘-Deoxyadenosine or 3‘-(Chloro or Fluoro)-3‘-deoxyadenosine1 Journal of Organic Chemistry. 63: 1205-1211. DOI: 10.1021/Jo971741U |
0.325 |
|
| 1997 |
Sorensen M, Steenberg B, Knipp GT, Wang W, Steffansen B, Frokjaer S, Borchardt RT. The effect of β-turn structure on the permeation of peptides across monolayers of bovine brain microvessel endothelial cells Pharmaceutical Research. 14: 1341-1348. PMID 9358545 DOI: 10.1023/A:1012104301773 |
0.336 |
|
| 1997 |
Knipp GT, Vander Velde DG, Siahaan TJ, Borchardt RT. The effect of β-turn structure on the passive diffusion of peptides across caco-2 cell monolayers Pharmaceutical Research. 14: 1332-1340. PMID 9358544 DOI: 10.1023/A:1012152117703 |
0.339 |
|
| 1997 |
Tamura K, Agrios KA, Vander Velde D, Aubé J, Borchardt RT. Effect of stereochemistry on the transport of Aca-linked beta-turn peptidomimetics across a human intestinal cell line. Bioorganic & Medicinal Chemistry. 5: 1859-66. PMID 9354242 DOI: 10.1016/S0968-0896(97)00115-6 |
0.328 |
|
| 1997 |
Capdevila A, Decha-Umphai W, Song KH, Borchardt RT, Wagner C. Pancreatic exocrine secretion is blocked by inhibitors of methylation. Archives of Biochemistry and Biophysics. 345: 47-55. PMID 9281310 DOI: 10.1006/Abbi.1997.0249 |
0.32 |
|
| 1997 |
Kupczyk-Subotkowska L, Tamura K, Pal D, Sakaeda T, Siahaan TJ, Stella VJ, Borchardt RT. Derivatives of melphalan designed to enhance drug accumulation in cancer cells Journal of Drug Targeting. 4: 359-370. PMID 9239576 DOI: 10.3109/10611869709017893 |
0.303 |
|
| 1997 |
Huang H, Yuan CS, Borchardt RT. Effect of limited proteolysis on the stability and enzymatic activity of human placental S-adenosylhomocysteine hydrolase. Protein Science : a Publication of the Protein Society. 6: 1482-90. PMID 9232649 DOI: 10.1002/Pro.5560060712 |
0.313 |
|
| 1997 |
Nerurkar MM, Ho NF, Burton PS, Vidmar TJ, Borchardt RT. Mechanistic roles of neutral surfactants on concurrent polarized and passive membrane transport of a model peptide in Caco-2 cells. Journal of Pharmaceutical Sciences. 86: 813-21. PMID 9232522 DOI: 10.1021/Js960483Y |
0.349 |
|
| 1997 |
Shan D, Nicolaou MG, Borchardt RT, Wang B. Prodrug strategies based on intramolecular cyclization reactions Journal of Pharmaceutical Sciences. 86: 765-767. PMID 9232513 DOI: 10.1021/Js970069D |
0.501 |
|
| 1997 |
Huang H, Yuan CS, Wnuk SF, Robins MJ, Borchardt RT. The mechanism of inactivation of human placental S-adenosylhomocysteine hydrolase by (E)-4',5'-didehydro-5'-methoxyadenosine and adenosine 5'-carboxaldehyde oxime. Archives of Biochemistry and Biophysics. 343: 109-17. PMID 9210652 DOI: 10.1006/Abbi.1997.0159 |
0.321 |
|
| 1997 |
Wnuk SF, Yuan CS, Borchardt RT, Balzarini J, De Clercq E, Robins MJ. Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. Journal of Medicinal Chemistry. 40: 1608-18. PMID 9171871 DOI: 10.1021/Jm960828P |
0.38 |
|
| 1997 |
Okumu FW, Pauletti GM, Vander Velde DG, Siahaan TJ, Borchardt RT. Effect of restricted conformational flexibility on the permeation of model hexapeptides across caco-2 cell monolayers Pharmaceutical Research. 14: 169-175. PMID 9090704 DOI: 10.1023/A:1012092409216 |
0.313 |
|
| 1997 |
Pauletti GM, Okumu FW, Borchardt RT. Effect of size and charge on the, passive diffusion of peptides across caco-2 cell monolayers via the paracellular pathway Pharmaceutical Research. 14: 164-168. PMID 9090703 DOI: 10.1023/A:1012040425146 |
0.316 |
|
| 1997 |
Pauletti GM, Gangwar S, Wang B, Borchardt RT. Esterase-sensitive cyclic prodrugs of peptides: Evaluation of a phenylpropionic acid promoiety in a model hexapeptide Pharmaceutical Research. 14: 11-17. PMID 9034215 DOI: 10.1023/A:1012091014242 |
0.537 |
|
| 1997 |
Wang B, Gangwar S, Pauletti GM, Siahaan TJ, Borchardt RT. Synthesis of a novel esterase-sensitive cyclic prodrug system for peptides that utilizes a 'trimethyl lock'-facilitated lactonization reaction Journal of Organic Chemistry. 62: 1363-1367. DOI: 10.1021/Jo961778Z |
0.535 |
|
| 1997 |
Gangwar S, Pauletti GM, Siahaan TJ, Stella VJ, Borchardt RT. Synthesis of a novel esterase-sensitive cyclic prodrug of a hexapeptide using an (acyloxy)alkoxy promoiety Journal of Organic Chemistry. 62: 1356-1362. DOI: 10.1021/Jo961696A |
0.361 |
|
| 1997 |
Gangwar S, Pauletti GM, Wang B, Siahaan TJ, Stella VJ, Borchardt RT. Prodrug strategies to enhance the intestinal absorption of peptides Drug Discovery Today. 2: 148-155. DOI: 10.1016/S1359-6446(97)01011-8 |
0.528 |
|
| 1997 |
Okumu FW, Cleland JL, Borchardt RT. The effect of size, charge and cyclization of model peptides on their in vitro release from dl–PLGA microspheres Journal of Controlled Release. 49: 133-140. DOI: 10.1016/S0168-3659(97)00065-5 |
0.304 |
|
| 1997 |
Gangwar S, Pauletti GM, Wang B, Siahaan TJ, Stella VJ, Borchardt RT. Novel esterase-sensitive cyclic prodrugs of a model hexapeptide having enhanced membrane permeability and enzymatic stability Pharmacochemistry Library. 28: 27-34. DOI: 10.1016/S0165-7208(97)80050-5 |
0.553 |
|
| 1996 |
Nicolaou MG, Wolfe JL, Schowen RL, Borchardt RT. Facilitated Intramolecular Conjugate Addition of Amides of 3-(3',6'-Dioxo-2',4'-dimethyl-1',4'-cyclohexadienyl)-3,3-dimethylpropionic Acid. 2. Kinetics of Degradation. The Journal of Organic Chemistry. 61: 6633-6638. PMID 11667533 DOI: 10.1021/Jo961069L |
0.323 |
|
| 1996 |
Burton PS, Conradi RA, Ho NF, Hilgers AR, Borchardt RT. How structural features influence the biomembrane permeability of peptides. Journal of Pharmaceutical Sciences. 85: 1336-40. PMID 8961149 DOI: 10.1021/Js960067D |
0.371 |
|
| 1996 |
Pauletti GM, Gangwar S, Okumu FW, Siahaan TJ, Stella VJ, Borchardt RT. Esterase-sensitive cyclic prodrugs of peptides: Evaluation of an acyloxyalkoxy promoiety in a model hexapeptide Pharmaceutical Research. 13: 1615-1623. PMID 8956324 DOI: 10.1023/A:1016472119387 |
0.34 |
|
| 1996 |
Yuan CS, Ault-Riché DB, Borchardt RT. Chemical modification and site-directed mutagenesis of cysteine residues in human placental S-adenosylhomocysteine hydrolase. The Journal of Biological Chemistry. 271: 28009-16. PMID 8910410 DOI: 10.1074/Jbc.271.45.28009 |
0.328 |
|
| 1996 |
Wnuk SF, Liu S, Yuan CS, Borchardt RT, Robins MJ. Inactivation of S-adenosyl-L-homocysteine hydrolase by amide and ester derivatives of adenosine-5'-carboxylic acid. Journal of Medicinal Chemistry. 39: 4162-6. PMID 8863793 DOI: 10.1021/Jm960313Y |
0.339 |
|
| 1996 |
Nerurkar MM, Burton PS, Borchardt RT. The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system. Pharmaceutical Research. 13: 528-34. PMID 8710741 DOI: 10.1023/A:1016033702220 |
0.341 |
|
| 1996 |
Liu S, Yuan CS, Borchardt RT. Aristeromycin-5'-carboxaldehyde: a potent inhibitor of S-adenosyl-L-homocysteine hydrolase. Journal of Medicinal Chemistry. 39: 2347-53. PMID 8691429 DOI: 10.1021/Jm950916U |
0.314 |
|
| 1996 |
Nicolaou MG, Yuan C, Borchardt RT. Phosphate Prodrugs for Amines Utilizing a Fast Intramolecular Hydroxy Amide Lactonization The Journal of Organic Chemistry. 61: 8636-8641. DOI: 10.1021/Jo961477P |
0.349 |
|
| 1996 |
Yuan CS, Liu S, Wnuk SF, Robins MJ, Borchardt RT. Design and synthesis of S-adenosylhomocysteine hydrolase inhibitors as broad-spectrum antiviral agents Advances in Antiviral Drug Design. 2: 41-88. DOI: 10.1016/S1075-8593(96)80103-1 |
0.323 |
|
| 1996 |
Pauletti GM, Gangwar S, Knipp GT, Nerurkar MM, Okumu FW, Tamura K, Siahaan TJ, Borchardt RT. Structural requirements for intestinal absorption of peptide drugs Journal of Controlled Release. 41: 3-17. DOI: 10.1016/0168-3659(96)01352-1 |
0.363 |
|
| 1996 |
Liu S, Wang B, Nicolaou MG, Borchardt RT. “Trimethyl lock” facilitated spirocyclizations: A structural analysis Journal of Chemical Crystallography. 26: 209-214. DOI: 10.1007/Bf01673672 |
0.472 |
|
| 1996 |
Wang B, Nicolaou MG, Liu S, Borchardt RT. Structural Analysis of a Facile Lactonization System Facilitated by a “Trimethyl Lock” Bioorganic Chemistry. 24: 39-49. DOI: 10.1006/Bioo.1996.0005 |
0.47 |
|
| 1995 |
Gupta RA, Yuan CS, Ault-Riché DB, Borchardt RT. Limited proteolysis of S-adenosylhomocysteine hydrolase: implications for the three-dimensional structure. Archives of Biochemistry and Biophysics. 319: 365-71. PMID 7786017 DOI: 10.1006/Abbi.1995.1306 |
0.348 |
|
| 1995 |
Chikhale EG, Chikhale PJ, Borchardt RT. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier Biochemical Pharmacology. 49: 941-945. PMID 7741766 DOI: 10.1016/0006-2952(95)00005-K |
0.319 |
|
| 1995 |
Li S, Schöneich C, Borchardt RT. Chemical pathways of peptide degradation. VIII. Oxidation of methionine in small model peptides by prooxidant/transition metal ion systems: influence of selective scavengers for reactive oxygen intermediates. Pharmaceutical Research. 12: 348-55. PMID 7617519 DOI: 10.1023/A:1016240115675 |
0.307 |
|
| 1995 |
Yuan CS, Borchardt RT. Photoaffinity labeling of human placental S-adenosylhomocysteine hydrolase with [2-3H]8-azido-adenosine. The Journal of Biological Chemistry. 270: 16140-6. PMID 7608178 DOI: 10.1074/Jbc.270.27.16140 |
0.346 |
|
| 1995 |
Yuan C, Liu S, Wnuk S, Robins M, Borchardt R. Rational Approaches to the Design of Mechanism-Based Inhibitors of S-Adenosylhomocysteine Hydrolase Nucleosides, Nucleotides and Nucleic Acids. 14: 439-447. DOI: 10.1080/15257779508012403 |
0.341 |
|
| 1995 |
Wang B, Liu S, Borchardt RT. Development of a Novel Redox-Sensitive Protecting Group for Amines Which Utilizes a Facilitated Lactonization Reaction The Journal of Organic Chemistry. 60: 539-543. DOI: 10.1021/Jo00108A013 |
0.462 |
|
| 1994 |
Gray RA, Vander Velde DG, Burke CJ, Manning MC, Middaugh CR, Borchardt RT. Delta-sleep-inducing peptide: solution conformational studies of a membrane-permeable peptide. Biochemistry. 33: 1323-31. PMID 8312250 DOI: 10.1021/Bi00172A006 |
0.34 |
|
| 1994 |
Stevenson CL, Friedman AR, Kubiak TM, Donlan ME, Borchardt RT. Effect of secondary structure on the rate of deamidation of several growth hormone releasing factor analogs. International Journal of Peptide and Protein Research. 42: 497-503. PMID 8307680 DOI: 10.1111/J.1399-3011.1993.Tb00356.X |
0.317 |
|
| 1994 |
Kim DC, Burton PS, Borchardt RT. A correlation between the permeability characteristics of a series of peptides using an in vitro cell culture model (Caco-2) and those using an in situ perfused rat ileum model of the intestinal mucosa. Pharmaceutical Research. 10: 1710-4. PMID 8302755 DOI: 10.1023/A:1018961828510 |
0.334 |
|
| 1994 |
Oliyai C, Borchardt RT. Chemical pathways of peptide degradation. VI. Effect of the primary sequence on the pathways of degradation of aspartyl residues in model hexapeptides. Pharmaceutical Research. 11: 751-8. PMID 8058648 DOI: 10.1023/A:1018944800691 |
0.319 |
|
| 1994 |
Chikhale EG, Ng KY, Burton PS, Borchardt RT. Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides. Pharmaceutical Research. 11: 412-9. PMID 8008709 DOI: 10.1023/A:1018969222130 |
0.358 |
|
| 1994 |
Miller DW, Keller BT, Borchardt RT. Identification and distribution of insulin receptors on cultured bovine brain microvessel endothelial cells: Possible function in insulin processing in the Blood-Brain barrier Journal of Cellular Physiology. 161: 333-341. PMID 7962117 DOI: 10.1002/Jcp.1041610218 |
0.441 |
|
| 1994 |
Yuan CS, Wnuk SF, Liu S, Robins MJ, Borchardt RT. (E)-5',6'-didehydro-6'-deoxy-6'-fluorohomoadenosine: a substrate that measures the hydrolytic activity of S-adenosylhomocysteine hydrolase. Biochemistry. 33: 12305-11. PMID 7918452 DOI: 10.1021/Bi00206A038 |
0.306 |
|
| 1994 |
Borchardt RT. Rational Delivery Strategies for the Design of Peptides with Enhanced Oral Delivery Drug Development and Industrial Pharmacy. 20: 469-483. DOI: 10.3109/03639049409038313 |
0.352 |
|
| 1994 |
Robins MJ, Wnuk SF, Mullah KB, Dalley NK, Yuan C, Lee Y, Borchardt RT. Nucleic Acid Related Compounds. 80. Synthesis of 5'-S-(Alkyl and aryl)-5'-fluoro-5'-thioadenosines with Xenon Difluoride or (Diethylamido)sulfur Trifluoride, Hydrolysis in Aqueous Buffer, and Inhibition of S-Adenosyl-L-homocysteine hydrolase by derived "Adenosine 5'-Aldehyde" Species The Journal of Organic Chemistry. 59: 544-555. DOI: 10.1021/Jo00082A010 |
0.31 |
|
| 1993 |
Liu S, Wnuk SF, Yuan C, Robins MJ, Borchardt RT. Adenosine-5'-carboxaldehyde: a potent inhibitor of S-adenosyl-L-homocysteine hydrolase. Journal of Medicinal Chemistry. 36: 883-7. PMID 8464042 DOI: 10.1021/Jm00059A013 |
0.306 |
|
| 1993 |
Oliyai C, Borchardt RT. Chemical pathways of peptide degradation. IV. Pathways, kinetics, and mechanism of degradation of an aspartyl residue in a model hexapeptide. Pharmaceutical Research. 10: 95-102. PMID 8430066 DOI: 10.1023/A:1018981231468 |
0.307 |
|
| 1993 |
Stevenson CL, Donlan ME, Friedman AR, Borchardt RT. Solution conformation of Leu27 hGRF(1-32)NH2 and its deamidation products by 2D NMR. International Journal of Peptide and Protein Research. 42: 24-32. PMID 8370640 DOI: 10.1111/J.1399-3011.1993.Tb00345.X |
0.316 |
|
| 1993 |
Tang AS, Chikhale PJ, Shah PK, Borchardt RT. Utilization of a Human Intestinal Epithelial Cell Culture System (Caco-2) for Evaluating Cytoprotective Agents Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 10: 1620-1626. PMID 8290475 DOI: 10.1023/A:1018976804403 |
0.314 |
|
| 1993 |
Li S, Schöneich C, Wilson GS, Borchardt RT. Chemical pathways of peptide degradation. V. Ascorbic acid promotes rather than inhibits the oxidation of methionine to methionine sulfoxide in small model peptides. Pharmaceutical Research. 10: 1572-9. PMID 8290469 DOI: 10.1023/A:1018960300769 |
0.345 |
|
| 1993 |
Schöneich C, Zhao F, Wilson GS, Borchardt RT. Iron-thiolate induced oxidation of methionine to methionine sulfoxide in small model peptides. Intramolecular catalysis by histidine. Biochimica Et Biophysica Acta. 1158: 307-22. PMID 8251532 DOI: 10.1016/0304-4165(93)90030-C |
0.325 |
|
| 1993 |
Kim DC, Harrison AW, Ruwart MJ, Wilkinson KF, Fisher JF, Hidalgo IJ, Borchardt RT. Evaluation of the bile acid transporter in enhancing intestinal permeability to renin-inhibitory peptides. Journal of Drug Targeting. 1: 347-59. PMID 8069578 DOI: 10.3109/10611869308996094 |
0.355 |
|
| 1993 |
Stevenson CL, Williams TD, Anderegg RJ, Borchardt RT. Identification and quantitation of tetrapeptide deamidation products by mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 10: 567-75. PMID 1463791 DOI: 10.1016/0731-7085(92)80082-X |
0.303 |
|
| 1993 |
Hasobe M, Liang H, Ault-Riche DB, Borcherding DR, Wolfe MS, Borchardt RT. (1′R, 2′S, 3′R)-9-(2′, 3′-Dihydroxycyclopentan-1′-yl)-Adenine and −3-Deaza-Adenine: Analogues of Aristeromycin Which Exhibit Potent Antiviral Activity with Reduced Cytotoxicity: Antiviral Chemistry & Chemotherapy. 4: 245-248. DOI: 10.1177/095632029300400408 |
0.335 |
|
| 1993 |
Ishii H, Hasobe M, McKee JG, Ault-Riché DB, Borchardt RT. Synergistic Antiviral Activity of Inhibitors of S-Adenosylhomocysteine Hydrolase and Ribavirin Antiviral Chemistry & Chemotherapy. 4: 127-130. DOI: 10.1177/095632029300400207 |
0.321 |
|
| 1992 |
Hu M, Borchardt RT. Transport of a large neutral amino acid in a human intestinal epithelial cell line (Caco-2): uptake and efflux of phenylalanine. Biochimica Et Biophysica Acta. 1135: 233-44. PMID 1623010 DOI: 10.1016/0167-4889(92)90226-2 |
0.319 |
|
| 1992 |
Robins MJ, Samano V, Zhang W, Balzarini J, De Clercq E, Borchardt RT, Lee Y, Yuan CS. Nucleic acid related compounds. 74. Synthesis and biological activity of 2'(and 3')-deoxy-2'(and 3')-methylenenucleoside analogues that function as mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase and/or ribonucleotide reductase. Journal of Medicinal Chemistry. 35: 2283-93. PMID 1613752 DOI: 10.1021/Jm00090A020 |
0.329 |
|
| 1992 |
Wolfe MS, Lee Y, Bartlett WJ, Borcherding DR, Borchardt RT. 4'-modified analogues of aristeromycin and neplanocin A: synthesis and inhibitory activity toward S-adenosyl-L-homocysteine hydrolase. Journal of Medicinal Chemistry. 35: 1782-91. PMID 1588558 DOI: 10.1021/Jm00088A013 |
0.338 |
|
| 1992 |
Wolfe JL, Vander Velde D, Borchardt RT. Facilitated intramolecular conjugate addition of N-(p-methoxyphenyl)-3-(3',6'-dioxo-2',4'-dimethylcyclohexa-1',4'-dienyl)-3,3-dimethylpropionamide. 1. Product characterization The Journal of Organic Chemistry. 57: 6138-6142. DOI: 10.1021/Jo00049A018 |
0.315 |
|
| 1992 |
Miller DW, Audus KL, Borchardt RT. Application of cultured endothelial cells of the brain microvasculature in the study of the blood-brain barrier Journal of Tissue Culture Methods. 14: 217-224. DOI: 10.1007/Bf01409014 |
0.46 |
|
| 1991 |
Hu M, Borchardt RT. Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2). Pharmaceutical Research. 7: 1313-9. PMID 2095572 DOI: 10.1023/A:1015906409585 |
0.304 |
|
| 1991 |
Shah PK, Borchardt RT. A comparison of peptidase activities and peptide metabolism in cultured mouse keratinocytes and neonatal mouse epidermis. Pharmaceutical Research. 8: 70-5. PMID 2014210 DOI: 10.1023/A:1015882323677 |
0.309 |
|
| 1991 |
Yeh JC, Borchardt RT, Vedani A. A molecular model for the active site of S-adenosyl-L-homocysteine hydrolase. Journal of Computer-Aided Molecular Design. 5: 213-34. PMID 1919618 DOI: 10.1007/Bf00124340 |
0.318 |
|
| 1991 |
Baranczyk-Kuzma A, Garren JA, Hidalgo IJ, Borchardt RT. Substrate specificity and some properties of phenol sulfotransferase from human intestinal Caco-2 cells. Life Sciences. 49: 1197-206. PMID 1910139 DOI: 10.1016/0024-3205(91)90568-V |
0.324 |
|
| 1991 |
Sufrin JR, Spiess AJ, Kramer DL, Libby PR, Miller JT, Bernacki RJ, Lee YH, Borchardt RT, Porter CW. Targeting 5'-deoxy-5'-(methylthio)adenosine phosphorylase by 5'-haloalkyl analogues of 5'-deoxy-5'-(methylthio)adenosine. Journal of Medicinal Chemistry. 34: 2600-6. PMID 1908523 DOI: 10.1021/Jm00112A039 |
0.326 |
|
| 1990 |
Patel K, Borchardt RT. Chemical pathways of peptide degradation. II. Kinetics of deamidation of an asparaginyl residue in a model hexapeptide. Pharmaceutical Research. 7: 703-11. PMID 2395797 DOI: 10.1023/A:1015807303766 |
0.32 |
|
| 1990 |
Patel K, Borchardt RT. Chemical pathways of peptide degradation. III. Effect of primary sequence on the pathways of deamidation of asparaginyl residues in hexapeptides. Pharmaceutical Research. 7: 787-93. PMID 2235875 DOI: 10.1023/A:1015999012852 |
0.337 |
|
| 1990 |
Hidalgo IJ, Borchardt RT. Transport of a large neutral amino acid (phenylalanine) in a human intestinal epithelial cell line: Caco-2. Biochimica Et Biophysica Acta. 1028: 25-30. PMID 2207118 DOI: 10.1016/0005-2736(90)90261-L |
0.31 |
|
| 1990 |
Audus KL, Bartel RL, Hidalgo IJ, Borchardt RT. The Use of Cultured Epithelial and Endothelial Cells for Drug Transport and Metabolism Studies Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 7: 435-451. PMID 2195492 DOI: 10.1023/A:1015800312910 |
0.313 |
|
| 1990 |
Bhatt NP, Patel K, Borchardt RT. Chemical pathways of peptide degradation. I. Deamidation of adrenocorticotropic hormone. Pharmaceutical Research. 7: 593-9. PMID 2164192 DOI: 10.1023/A:1015862026539 |
0.322 |
|
| 1990 |
Borchardt RT. Assessment of Transport Barriers Using Cell and Tissue Culture Systems Drug Development and Industrial Pharmacy. 16: 2595-2612. DOI: 10.3109/03639049009058549 |
0.326 |
|
| 1989 |
Shah MV, Audus KL, Borchardt RT. The Application of Bovine Brain Microvessel Endothelial-Cell Monolayers Grown onto Polycarbonate Membranes in Vitro to Estimate the Potential Permeability of Solutes Through the Blood–Brain Barrier Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 6: 624-627. PMID 2798313 DOI: 10.1023/A:1015913817221 |
0.302 |
|
| 1989 |
Baranczyk-Kuzma A, Audus KL, Borchardt RT. Substrate specificity of phenol sulfotransferase from primary cultures of bovine brain microvessel endothelium Neurochemical Research. 14: 689-691. PMID 2779729 DOI: 10.1007/Bf00964880 |
0.328 |
|
| 1989 |
Smith KR, Borchardt RT. Permeability and Mechanism of Albumin, Cationized Albumin, and Glycosylated Albumin Transcellular Transport Across Monolayers of Cultured Bovine Brain Capillary Endothelial Cells Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 6: 466-473. PMID 2762222 DOI: 10.1023/A:1015960205409 |
0.312 |
|
| 1989 |
Scriba GK, Borchardt RT. Metabolism of catecholamine esters by cultured bovine brain microvessel endothelial cells. Journal of Neurochemistry. 53: 610-5. PMID 2746238 DOI: 10.1111/J.1471-4159.1989.Tb07377.X |
0.336 |
|
| 1989 |
Borchardt R, Mazer N, Rytting J, Shek E, Ziv E, Touitou E, Higuchi W. The delivery of peptides Journal of Pharmaceutical Sciences. 78: 883-892. DOI: 10.1002/Jps.2600781102 |
0.317 |
|
| 1988 |
Smith KR, Kato A, Borchardt RT. Characterization of specific receptors for atrial natriuretic factor on cultured bovine brain capillary endothelial cells Biochemical and Biophysical Research Communications. 157: 308-314. PMID 2848519 DOI: 10.1016/S0006-291X(88)80048-2 |
0.309 |
|
| 1988 |
van Nispen JW, Hichens M, Sauter A, Lingeman H, Cubbins DC, McMartin C, Webb RL, Wennogle LP, Wysowskyi HE, Zimmerman MB, Lee VHL, Sandow J, Seidel H, Schmiedel R, Keller BT, ... ... Borchardt RT, et al. Abstracts of lectures symposium disposition and delivery of peptide drugs Pharmaceutisch Weekblad. 10: 30-50. DOI: 10.1007/Bf01966433 |
0.303 |
|
| 1987 |
Matuszewska B, Borchardt RT. The mechanism of inhibition of Alcaligenes faecalis S-adenosylhomocysteine hydrolase by neplanocin A. Archives of Biochemistry and Biophysics. 256: 50-5. PMID 3606132 DOI: 10.1016/0003-9861(87)90424-3 |
0.305 |
|
| 1987 |
Fisher EW, Decedue CJ, Keller BT, Borchardt RT. Neplanocin A inhibition of S-adenosylhomocysteine hydrolase in Alcaligenes faecalis has no effect on growth of the microorganism. The Journal of Antibiotics. 40: 873-81. PMID 3112082 DOI: 10.7164/Antibiotics.40.873 |
0.308 |
|
| 1987 |
Hasobe M, McKee JG, Borcherding DR, Borchardt RT. 9-(trans-2',trans-3'-Dihydroxycyclopent-4'-enyl)-adenine and -3-deazaadenine: analogs of neplanocin A which retain potent antiviral activity but exhibit reduced cytotoxicity. Antimicrobial Agents and Chemotherapy. 31: 1849-51. PMID 2449123 DOI: 10.1128/Aac.31.11.1849 |
0.316 |
|
| 1987 |
Ramakrishnan V, Borchardt RT. Adenosine dialdehyde and neplanocin A: Potent inhibitors of S-adenosylhomocysteine hydrolase in neuroblastoma N2a cells Neurochemistry International. 10: 423-431. DOI: 10.1016/0197-0186(87)90068-4 |
0.329 |
|
| 1986 |
Patel-Thombre U, Borchardt RT. Adenine nucleoside dialdehydes: potent inhibitors of bovine liver S-adenosylhomocysteine hydrolase. Biochemistry. 24: 1130-6. PMID 4096893 DOI: 10.1021/Bi00326A010 |
0.326 |
|
| 1986 |
Bartel RL, Borchardt RT. Quantitation of S-adenosylhomocysteine hydrolase in mouse L929 cells using the inhibitor neplanocin A. Analytical Biochemistry. 149: 191-6. PMID 4073475 DOI: 10.1016/0003-2697(85)90494-4 |
0.336 |
|
| 1986 |
Audus KL, Borchardt RT. Characteristics of the large neutral amino acid transport system of bovine brain microvessel endothelial cell monolayers Journal of Neurochemistry. 47: 484-488. PMID 3734791 DOI: 10.1111/J.1471-4159.1986.Tb04527.X |
0.32 |
|
| 1986 |
Baranczyk-Kuzma A, Audus KL, Borchardt RT. Catecholamine-metabolizing enzymes of bovine brain microvessel endothelial cell monolayers Journal of Neurochemistry. 46: 1956-1960. PMID 2871135 DOI: 10.1111/J.1471-4159.1986.Tb08519.X |
0.308 |
|
| 1986 |
Audus KL, Borchardt RT. Characterization of an In Vitro Blood–Brain Barrier Model System for Studying Drug Transport and Metabolism Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 3: 81-87. DOI: 10.1023/A:1016337202335 |
0.321 |
|
| 1985 |
Porter PA, Osiecka I, Borchardt RT, Fix JA, Frost L, Gardner C. In Vitro Drug Absorption Models. II. Salicylate, Cefoxitin, α-Methyldopa and Theophylline Uptake in Cells and Rings: Correlation with In Vivo Bioavailability. Pharmaceutical Research. 2: 293-8. PMID 24271126 DOI: 10.1023/A:1016393618111 |
0.313 |
|
| 1985 |
Osiecka I, Porter PA, Borchardt RT, Fix JA, Gardner CR. In vitro drug absorption models. I. Brush border membrane vesicles, isolated mucosal cells and everted intestinal rings: characterization and salicylate accumulation. Pharmaceutical Research. 2: 284-93. PMID 24271125 DOI: 10.1023/A:1016341601273 |
0.332 |
|
| 1985 |
Matuszewska B, Borchardt RT. Rat kidney histamine N-methyltransferase: purification and partial characterization. Preparative Biochemistry. 15: 145-57. PMID 4059182 DOI: 10.1080/10826068508062268 |
0.311 |
|
| 1985 |
Houston DM, Matuszewska B, Borchardt RT. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 10. Base- and amino acid modified analogues of S-aristeromycinyl-L-homocysteine. Journal of Medicinal Chemistry. 28: 478-82. PMID 3981540 DOI: 10.1002/Chin.198531335 |
0.325 |
|
| 1985 |
Houston DM, Dolence EK, Keller BT, Patel-Thombre U, Borchardt RT. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 9. 2',3'-Dialdehyde derivatives of carbocyclic purine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase. Journal of Medicinal Chemistry. 28: 471-7. PMID 3981539 DOI: 10.1002/Chin.198531336 |
0.324 |
|
| 1985 |
Houston DM, Dolence EK, Keller BT, Patel-Thombre U, Borchardt RT. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 8. Molecular dissections of carbocyclic 3-deazaadenosine as inhibitors of S-adenosylhomocysteine hydrolase. Journal of Medicinal Chemistry. 28: 467-71. PMID 3981538 DOI: 10.1002/Chin.198531233 |
0.315 |
|
| 1984 |
Keller BT, Borchardt RT. Metabolic conversion of neplanocin A to S-neplanocylmethionine by mouse L 929 cells. Biochemical and Biophysical Research Communications. 120: 131-7. PMID 6712684 DOI: 10.1016/0006-291X(84)91423-2 |
0.338 |
|
| 1984 |
Liang NY, Chandra A, Tessel RE, Grunewald GL, Borchardt RT. Inhibitors of phenylethanolamine-N-methyltransferase: effects on brain catecholamine content and blood pressure in DOCA-salt hypertensive rats. Research Communications in Chemical Pathology and Pharmacology. 46: 319-29. PMID 6515125 DOI: 10.1016/S0022-5347(17)49412-2 |
0.605 |
|
| 1983 |
Borchardt RT, Schasteen CS, Wu SE. Phenol sulfotransferase. II. Inactivation by phenylglyoxal, N-ethylmaleimide and ribonucleotide 2',3'-dialdehydes. Biochimica Et Biophysica Acta. 708: 280-93. PMID 6959651 DOI: 10.1016/0167-4838(82)90438-1 |
0.337 |
|
| 1983 |
Borchardt RT, Schasteen CS. Phenol sulfotransferase. I. Purification of a rat liver enzyme by affinity chromatography. Biochimica Et Biophysica Acta. 708: 272-9. PMID 6959650 DOI: 10.1016/0167-4838(82)90437-X |
0.324 |
|
| 1982 |
Rafferty MF, Krass P, Borchardt RT, Grunewald GL. Importance of the aromatic ring in adrenergic amines. 8. 2-(Aminomethyl)-trans-2-decalols as inhibitors of norepinephrine N-methyltransferase. Journal of Medicinal Chemistry. 25: 1250-2. PMID 7143367 DOI: 10.1002/Chin.198311323 |
0.318 |
|
| 1982 |
Grunewald GL, Monn JA, Rafferty MF, Borchardt RT, Krass P. Probes of the active site of norepinephrine N-methyltransferase: effect of hydrophobic and hydrophilic interactions on side-chain binding of amphetamine and alpha-methylbenzylamine. Journal of Medicinal Chemistry. 25: 1248-50. PMID 7143366 DOI: 10.1002/Chin.198311322 |
0.312 |
|
| 1982 |
Rafferty MF, Borchardt RT, Grunewald GL. Directional probes of the hydrophobic component of the aromatic ring binding site of norepinephrine N-methyltransferase. Journal of Medicinal Chemistry. 25: 1204-8. PMID 7143357 DOI: 10.1002/Chin.198310180 |
0.309 |
|
| 1982 |
Rafferty MF, Wilson DS, Monn JA, Krass P, Borchardt RT, Grunewald GL. Importance of the aromatic ring in adrenergic amines. 7. Comparison of the stereoselectivity of norepinephrine N-methyltransferase for aromatic vs. nonaromatic substrates and inhibitors. Journal of Medicinal Chemistry. 25: 1198-204. PMID 7143356 DOI: 10.1002/Chin.198310168 |
0.328 |
|
| 1982 |
Borchardt RT, Huber JA. Catechol O-methyltransferase. 11. Inactivation by 5-hydroxy-3-mercapto-4-methoxybenzoic acid Journal of Medicinal Chemistry. 25: 321-323. PMID 7069707 DOI: 10.1021/Jm00345A017 |
0.323 |
|
| 1982 |
Borchardt RT, Bhatia P. Catechol O-methyltransferase. 12. Affinity labeling the active site with the oxidation products of 5,6-dihydroxyindole Journal of Medicinal Chemistry. 25: 263-271. PMID 7069705 DOI: 10.1002/Chin.198233173 |
0.338 |
|
| 1982 |
Borchardt RT, Huber JA, Houston M. Catechol o-methyltransferase. 10. 5-Substituted 3-hydroxy-4-methoxybenzoic acids (isovanillic acids) and 5-substituted 3-hydroxy-4-methoxybenzaldehydes (isovanillins) as potential inhibitors Journal of Medicinal Chemistry. 25: 258-263. PMID 7069704 DOI: 10.1002/Chin.198233149 |
0.316 |
|
| 1981 |
Pegg AE, Borchardt RT, Coward JK. Effects of inhibitors of spermidine and spermine synthesis on polyamine concentrations and growth of transformed mouse fibroblasts. The Biochemical Journal. 194: 79-89. PMID 7305994 DOI: 10.1042/Bj1940079 |
0.307 |
|
| 1981 |
Davis DP, Borchardt RT, Grunewald GL. Importance of the aromatic ring in adrenergic amines. 6. Nonaromatic analogues of phenylethanolamine as inhibitors of phenylethanolamine N-methyltransferase: role of pi-electronic and steric interactions. Journal of Medicinal Chemistry. 24: 12-6. PMID 7205869 DOI: 10.1002/Chin.198123180 |
0.301 |
|
| 1980 |
Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE. Studies of inhibition of rat spermidine synthase and spermine synthase. The Biochemical Journal. 187: 419-28. PMID 7396856 DOI: 10.1042/Bj1870419 |
0.326 |
|
| 1978 |
Borchardt RT, Wu YS, Wu BS. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 7. Role of the ribosyl moiety in enzymatic binding of S-adenosyl-L-homocysteine and S-adenosyl-L-methionine. Journal of Medicinal Chemistry. 21: 1307-10. PMID 722739 DOI: 10.1002/Chin.197918371 |
0.3 |
|
| 1978 |
Borchardt RT, Wu YS, Wu BS. Affinity labeling of histamine N-methyltransferase by 2',3'-dialdehyde derivatives of S-adenosylhomocysteine and S-adenosylmethionine. Kinetics of inactivation. Biochemistry. 17: 4145-52. PMID 708699 DOI: 10.1021/Bi00613A007 |
0.303 |
|
| 1978 |
Tessel RE, Kennedy LE, Burgess SK, Borchardt RT. Epinephrine in rat hypothalamus: antagonism by desipramine of 6-hydroxydopamine-induced depletion. Brain Research. 153: 615-7. PMID 698800 DOI: 10.1016/0006-8993(78)90347-5 |
0.593 |
|
| 1978 |
Leboy PS, Glick JM, Steiner FG, Haney S, Borchardt RT. S-adenosylhomocysteine analogues as inhibitors of specific tRNA methylation Bba Section Nucleic Acids and Protein Synthesis. 520: 153-163. PMID 698227 DOI: 10.1016/0005-2787(78)90016-3 |
0.355 |
|
| 1978 |
Borchardt RT, Wu SE, Schasteen CS. Adenosine 5'-diphosphate dialdehyde: an affinity labeling reagent for phenol-sulfotransferase. Biochemical and Biophysical Research Communications. 81: 841-9. PMID 666796 DOI: 10.1016/0006-291X(78)91428-6 |
0.332 |
|
| 1978 |
Borchardt RT, Cheng CF. Purification and characterization of rat liver microsomal thiol methyltransferase. Biochimica Et Biophysica Acta. 522: 340-53. PMID 623768 DOI: 10.1016/0005-2744(78)90068-2 |
0.327 |
|
| 1978 |
Borchardt R, Cheng CF. Purification and characterization of rat heart and brain catechol methyltransferase. Biochimica Et Biophysica Acta. 522: 49-62. PMID 413582 DOI: 10.1016/0005-2744(78)90321-2 |
0.313 |
|
| 1977 |
Borchardt RT, Schasteen CS. Phenol-sulfotransferase inactivation by 2,3-butanedione and phenylglyoxal: evidence for an active site arginyl residue. Biochemical and Biophysical Research Communications. 78: 1067-73. PMID 911328 DOI: 10.1016/0006-291X(77)90529-0 |
0.318 |
|
| 1977 |
Borchardt RT, Wu YS, Wu BS. S-adenosyl-L-homocysteine dialdehyde: an affinity labeling reagent for histamine-N-methyltransferase. Biochemical and Biophysical Research Communications. 78: 1025-33. PMID 911324 DOI: 10.1016/0006-291X(77)90524-1 |
0.331 |
|
| 1977 |
Borchardt RT, Thakker DR. Labeling of catechol-O-methyltransferase with N-haloacetyl derivatives. Methods in Enzymology. 46: 554-61. PMID 909444 DOI: 10.1016/S0076-6879(77)46068-3 |
0.32 |
|
| 1976 |
Borchardt RT, Smissman EE, Nerland D, Reid JR. Catechol O methyltransferase. 7. Affinity labeling with the oxidation products of 6 aminodopamine Journal of Medicinal Chemistry. 19: 30-37. PMID 1246049 DOI: 10.1002/Chin.197617179 |
0.774 |
|
| 1976 |
Smissman EE, Reid JR, Walsh DA, Borchardt RT. Synthesis and biological activity of 2- and 4-substituted 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines Journal of Medicinal Chemistry. 19: 127-131. PMID 1246034 DOI: 10.1002/Chin.197617239 |
0.582 |
|
| 1976 |
Borchardt RT, Reid JR, Thakker DR. Catechol O-methyltransferase. 9. Mechanism of inactivation by 6-hydroxydopamine. Journal of Medicinal Chemistry. 19: 1201-9. PMID 994150 DOI: 10.1002/Chin.197705184 |
0.351 |
|
| 1976 |
Borchardt RT, Wu YS, Huber JA, Wycpalek AF. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 6. Structural modifications of S-adenosylmethionine Journal of Medicinal Chemistry. 19: 1104-1110. PMID 978675 DOI: 10.1002/Chin.197652393 |
0.332 |
|
| 1976 |
Borchardt RT, Huber JA, Wu YS. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 4. Further modifications of the amino acid and base portions of S-adenosyl-L-homocysteine Journal of Medicinal Chemistry. 19: 1094-1099. PMID 978673 DOI: 10.1021/Jm00231A003 |
0.307 |
|
| 1976 |
Borchardt RT, Thakker DR, Warner VD, Mirth DB, Sane JN. Catechol O-methyltransferase. 8. Structure-activity relationships for inhibtion by 8-hydroxyquinolines. Journal of Medicinal Chemistry. 19: 558-60. PMID 817025 DOI: 10.1021/Jm00226A025 |
0.305 |
|
| 1976 |
Borchardt RT, Thakker DR. Evidence for sulfhydryl groups at the active site of catechol-O-methyltransferase. Biochimica Et Biophysica Acta. 445: 598-609. PMID 9991 DOI: 10.1016/0005-2744(76)90113-3 |
0.328 |
|
| 1976 |
SMISSMAN EE, REID JR, WALSH DA, BORCHARDT RT. ChemInform Abstract: SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2- AND 4-SUBSTITUTED 6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINES Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/chin.197617239 |
0.513 |
|
| 1976 |
BORCHARDT RT, SMISSMAN EE, NERLAND D, REID JR. ChemInform Abstract: CATECHOL O-METHYLTRANSFERASE. 7. AFFINITY LABELING WITH THE OXIDATION PRODUCTS OF 6-AMINODOPAMINE Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/chin.197617179 |
0.734 |
|
| 1975 |
Borchardt RT, Wu YS. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 3. Modifications of the sugar portion of S-adenosylhomocysteine. Journal of Medicinal Chemistry. 18: 300-4. PMID 1133821 DOI: 10.1021/Jm00237A018 |
0.312 |
|
| 1975 |
Borchardt RT, Cheng CF, Thakker DR. Purification of catechol-O-methyltransferase by affinity chromatography. Biochemical and Biophysical Research Communications. 63: 69-77. PMID 1125027 DOI: 10.1016/S0006-291X(75)80012-X |
0.3 |
|
| 1975 |
Borchardt RT, Thakker DR. Catechol O-methyltransferase. 6. Affinity labeling with N-haloacetyl-3,5-dimethoxy-4-hydroxyphenylalkylamines. Journal of Medicinal Chemistry. 18: 152-8. PMID 1120981 DOI: 10.1021/Jm00236A008 |
0.318 |
|
| 1975 |
Borchardt RT, Thakker DR. Affinity labeling of catechol O-methyltransferase by N-haloacetyl derivatives of 3,5-dimethoxy-4-hydroxyphenylethylamine and 3,4-dimethoxy-5-hydroxyphenylethylamine. Kinetics of inactivation. Biochemistry. 14: 4543-51. PMID 240407 DOI: 10.1021/Bi00691A033 |
0.329 |
|
| 1974 |
Borchardt RT, Huber JA, Wu YS. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 2. Modification of the base portion of S-adenosylhomocysteine Journal of Medicinal Chemistry. 17: 868-873. PMID 4845380 DOI: 10.1021/Jm00254A017 |
0.349 |
|
| 1973 |
Borchardt RT, Thakker D. Affinity labeling of catechol-O-methyltransferase with N-iodoacetyl-3,5-dimethoxy-4-hydroxyphenylethylamine. Biochemical and Biophysical Research Communications. 54: 1233-9. PMID 4753192 DOI: 10.1016/0006-291X(73)90824-3 |
0.31 |
|
| 1972 |
Smissman EE, Borchardt RT, Schowen KB. Conformational aspects of systems related to acetylcholine. 4. The syntheses of the dl-2-dimethylamino-trans-decalin methiodides. Journal of Medicinal Chemistry. 15: 545-8. PMID 5035280 DOI: 10.1021/Jm00275A027 |
0.529 |
|
| 1972 |
SMISSMAN EE, BORCHARDT RT, SCHOWEN KB. ChemInform Abstract: KONFORMATIVE ASPEKTE BEI MIT ACETYLCHOLIN VERWANDTEN SYST. 4. MITT. DIE SYNTH. DER D,L-2-DIMETHYLAMINO-TRANS-DECALIN-METHOJODIDE Chemischer Informationsdienst. 3: no-no. DOI: 10.1002/Chin.197236242 |
0.522 |
|
| 1971 |
Smissman EE, Borchardt RT. A conformational study of catecholamine receptor sites. 5. Syntheses of dl-3-amino-2-(3,4-dihydroxyphenyl)-trans-2-decalol hydrochlorides. Journal of Medicinal Chemistry. 14: 377-82. PMID 5117682 DOI: 10.1021/Jm00287A001 |
0.553 |
|
| 1971 |
Smissman EE, Borchardt RT. Conformational study oof catecholamine receptor sites. 7. Syntheses of erythro- and threo-3-amino-2-(3,4-dihydroxyphenyl)-2-butanol hydrochlorides and erythro- and threo-2-amino-3-(3,4-dihydroxyphenyl)butane hydrochlorides. Journal of Medicinal Chemistry. 14: 702-7. PMID 5114066 DOI: 10.1021/Jm00290A008 |
0.565 |
|
| 1971 |
Smissman E, Borchardt R. Additions and Corrections - A Conformational Study of Catecholamine Receptor Sites. 5. Syntheses of dl-3-Amino-2-(3,4-dihydroxyphenyl)-trans-2-decalol Hydrochlorides. Journal of Medicinal Chemistry. 14: 1251-1251. DOI: 10.1021/jm00294a609 |
0.508 |
|
| 1971 |
SMISSMAN EE, BORCHARDT RT. ChemInform Abstract: KONFORM.-STUDIE UEBER DIE CATECHOLAMIN-REZEPTORSTELLEN 7. MITT. SYNTH. VON ERYTHRO- UND THREO-3-AMINO-2-(3,4-DIHYDROXYPHENYL)-BUTANOL-(2)-HYDROCHLORIDEN UND ERYTHRO- UND THREO-2-AMINO-3-(3,4-DIHYDROXYPHENYL)-BUTANHYDROCHLORIDEN Chemischer Informationsdienst. Organische Chemie. 2: no-no. DOI: 10.1002/chin.197150257 |
0.515 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 1991 |
Amsberry KL, Borchardt RT. Amine prodrugs which utilize hydroxy amide lactonization. I. A potential redox-sensitive amide prodrug. Pharmaceutical Research. 8: 323-30. PMID 2052518 DOI: 10.1023/A:1015885213625 |
0.3 |
|
| 1985 |
Sinhababu AK, Ghosh AK, Borchardt RT. Molecular mechanism of action of 5,6-dihydroxytryptamine. Synthesis and biological evaluation of 4-methyl-, 7-methyl-, and 4,7-dimethyl-5,6-dihydroxytryptamines. Journal of Medicinal Chemistry. 28: 1273-9. PMID 4032430 DOI: 10.1002/Chin.198552206 |
0.299 |
|
| 1988 |
Narayanan SR, Borchardt RT. Purification of bovine liver S-adenosylhomocysteine hydrolase by affinity chromatography on blue dextran-agarose. Biochimica Et Biophysica Acta. 965: 22-8. PMID 3349103 DOI: 10.1016/0304-4165(88)90146-8 |
0.299 |
|
| 1994 |
Wnuk SF, Yuan CS, Borchardt RT, Balzarini J, De Clercq E, Robins MJ. Nucleic acid related compounds. 84. Synthesis of 6'-(E and Z)-halohomovinyl derivatives of adenosine, inactivation of S-adenosyl-L-homocysteine hydrolase, and correlation of anticancer and antiviral potencies with enzyme inhibition. Journal of Medicinal Chemistry. 37: 3579-87. PMID 7932585 DOI: 10.1021/Jm00047A015 |
0.299 |
|
| 1998 |
Khossravi M, Borchardt RT. Chemical pathways of peptide degradation: IX. Metal-catalyzed oxidation of histidine in model peptides. Pharmaceutical Research. 15: 1096-102. PMID 9688066 DOI: 10.1023/A:1011946631197 |
0.299 |
|
| 1992 |
Liu S, Wolfe MS, Yuan C, Ali SM, Borchardt RT. Synthesis and evaluation of 4′-5′-dehydro-5′-fluoroaristeromycins as S-adenosyl-L-homocysteine (AdoHcy) hydrolase inhibitors Bioorganic & Medicinal Chemistry Letters. 2: 1741-1744. DOI: 10.1016/S0960-894X(00)80467-9 |
0.298 |
|
| 1991 |
Hidalgo IJ, Hillgren KM, Grass GM, Borchardt RT. Characterization of the unstirred water layer in Caco-2 cell monolayers using a novel diffusion apparatus. Pharmaceutical Research. 8: 222-7. PMID 2023871 DOI: 10.1023/A:1015848205447 |
0.298 |
|
| 1989 |
Paisley S, Hasobe M, Borchardt R. Elucidation of the Mechanism by Which 9-(Trans-2', Trans-3'-Dihydroxycyclopent-4'-enyl)-Adenine Lnactivates S-Adenosylhomocysteine Hydrolase and Elevates Cellular Levels of Sadenosylhomocysteinew Nucleosides, Nucleotides and Nucleic Acids. 8: 689-698. DOI: 10.1080/07328318908054208 |
0.297 |
|
| 1993 |
Barańczyk-Kuźma A, Drobisz D, Audus KL, Borchardt RT. Sulfation of hypertensive and hypotensive drugs by monkey brain phenol sulfotransferase Neurochemical Research. 18: 783-786. PMID 8367023 DOI: 10.1007/Bf00966773 |
0.297 |
|
| 1988 |
van Bree JBMM, Audus KL, Borchardt RT. Carrier-Mediated Transport of Baclofen Across Monolayers of Bovine Brain Endothelial Cells in Primary Culture Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 5: 369-371. PMID 3244648 DOI: 10.1023/A:1015959628008 |
0.297 |
|
| 1995 |
Li S, Nguyen TH, Schoneich C, Borchardt RT. Aggregation and precipitation of human relaxin induced by metal-catalyzed oxidation Biochemistry. 34: 5762-5772. PMID 7727437 DOI: 10.1021/Bi00017A008 |
0.296 |
|
| 1993 |
Ng KY, Borchardt RT. Biotin transport in a human intestinal epithelial cell line (Caco-2). Life Sciences. 53: 1121-7. PMID 8371628 DOI: 10.1016/0024-3205(93)90548-H |
0.296 |
|
| 1997 |
Knipp GT, Ho NF, Barsuhn CL, Borchardt RT. Paracellular diffusion in Caco-2 cell monolayers: effect of perturbation on the transport of hydrophilic compounds that vary in charge and size. Journal of Pharmaceutical Sciences. 86: 1105-10. PMID 9344165 DOI: 10.1021/Js9700309 |
0.296 |
|
| 1988 |
Borcherding DR, Narayanan S, Hasobe M, McKee JG, Keller BT, Borchardt RT. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase. Journal of Medicinal Chemistry. 31: 1729-38. PMID 3411600 DOI: 10.1021/Jm00117A011 |
0.295 |
|
| 1998 |
Turner MA, Yuan CS, Borchardt RT, Hershfield MS, Smith GD, Howell PL. Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength. Nature Structural Biology. 5: 369-76. PMID 9586999 DOI: 10.1038/Nsb0598-369 |
0.294 |
|
| 2013 |
Stevenson CL, Anderegg RJ, Borchardt RT. Probing the helical content of growth hormone-releasing factor analogs using electrospray ionization mass spectrometry. Journal of the American Society For Mass Spectrometry. 4: 646-51. PMID 24227668 DOI: 10.1016/1044-0305(93)85029-W |
0.293 |
|
| 2005 |
Krogmeier SL, Reddy DS, Vander Velde D, Lushington GH, Siahaan TJ, Middaugh CR, Borchardt RT, Topp EM. Deamidation of model beta-turn cyclic peptides in the solid state. Journal of Pharmaceutical Sciences. 94: 2616-31. PMID 16258986 DOI: 10.1002/Jps.20468 |
0.293 |
|
| 1997 |
Li S, Patapoff TW, Overcashier D, Hsu C, Nguyen TH, Borchardt RT. Effects of reducing sugars on the chemical stability of human relaxin in the lyophilized state. Journal of Pharmaceutical Sciences. 85: 873-7. PMID 8863280 DOI: 10.1021/Js950456S |
0.293 |
|
| 1990 |
Hidalgo IJ, Borchardt RT. Transport of bile acids in a human intestinal epithelial cell line, Caco-2. Biochimica Et Biophysica Acta. 1035: 97-103. PMID 2383583 DOI: 10.1016/0304-4165(90)90179-Z |
0.292 |
|
| 1999 |
Wnuk SF, Yuan CS, Borchardt RT, Robins MJ. Design and biological evaluation of new mechanism-based inhibitors of S- adenosyl-L-homocysteine hydrolase Nucleosides and Nucleotides. 18: 595-596. DOI: 10.1080/15257779908041506 |
0.292 |
|
| 2006 |
Li B, Schowen RL, Topp EM, Borchardt RT. Effect of N-1 and N-2 residues on peptide deamidation rate in solution and solid state. The Aaps Journal. 8: E166-73. PMID 16584125 DOI: 10.1208/Aapsj080120 |
0.291 |
|
| 1974 |
Borchardt RT, Cheng CF, Cooke PH. The purification and kinetic properties of liver microsomal-catechol-o-methyltransferase. Life Sciences. 14: 1089-1100. PMID 4822918 DOI: 10.1016/0024-3205(74)90233-1 |
0.291 |
|
| 1992 |
Takakura Y, Trammel AM, Kuentzel SL, Raub TJ, Davies A, Baldwin SA, Borchardt RT. Hexose uptake in primary cultures of bovine brain microvessel endothelial cells. II. Effects of conditioned media from astroglial and glioma cells. Biochimica Et Biophysica Acta. 1070: 11-9. PMID 1751516 DOI: 10.1016/0005-2736(91)90140-4 |
0.291 |
|
| 1982 |
Yoffe JR, Borchardt RT. Effects of ascorbic acid on the uptake of serotonin in differentiated neuroblastoma cells. Life Sciences. 31: 489-93. PMID 7132562 DOI: 10.1016/0024-3205(82)90335-6 |
0.29 |
|
| 2013 |
Anderegg RJ, Wagner DS, Stevenson CL, Borchardt RT. The mass spectrometry of helical unfolding in peptides. Journal of the American Society For Mass Spectrometry. 5: 425-33. PMID 24222597 DOI: 10.1016/1044-0305(94)85058-5 |
0.29 |
|
| 2009 |
Cai S, Li QS, Fang J, Borchardt RT, Kuczera K, Middaugh CR, Schowen RL. The rationale for targeting the NAD/NADH cofactor binding site of parasitic S-adenosyl-L-homocysteine hydrolase for the design of anti-parasitic drugs. Nucleosides, Nucleotides & Nucleic Acids. 28: 485-503. PMID 20183598 DOI: 10.1080/15257770903051031 |
0.29 |
|
| 1979 |
Borchardt RT, Eiden LE, Wu B, Rutledge CO. Sinefungin, a potent inhibitor or S-adenosylmethionine: protein O-methyltransferase. Biochemical and Biophysical Research Communications. 89: 919-24. PMID 486211 DOI: 10.1016/0006-291X(79)91866-7 |
0.289 |
|
| 1991 |
Takakura Y, Audus KL, Borchardt RT. Blood-brain barrier: transport studies in isolated brain capillaries and in cultured brain endothelial cells Advances in Pharmacology (San Diego, Calif.). 22: 137-165. PMID 1958501 DOI: 10.1016/S1054-3589(08)60034-4 |
0.289 |
|
| 2004 |
Våbenø J, Lejon T, Nielsen CU, Steffansen B, Chen W, Ouyang H, Borchardt RT, Luthman K. Phe-Gly dipeptidomimetics designed for the di-/tripeptide transporters PEPT1 and PEPT2: synthesis and biological investigations. Journal of Medicinal Chemistry. 47: 1060-9. PMID 14761208 DOI: 10.1021/Jm031022+ |
0.289 |
|
| 1996 |
Tamura K, Bhatnagar PK, Takata JS, Lee CP, Smith PL, Borchardt RT. Metabolism, uptake, and transepithelial transport of the diastereomers of Val-Val in the human intestinal cell line, Caco-2. Pharmaceutical Research. 13: 1213-8. PMID 8865315 DOI: 10.1023/A:1016068421243 |
0.289 |
|
| 1989 |
Hidalgo IJ, Raub TJ, Borchardt RT. Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability Gastroenterology. 96: 736-749. DOI: 10.1016/S0016-5085(89)80072-1 |
0.289 |
|
| 2002 |
Elrod P, Zhang J, Yang X, Yin D, Hu Y, Borchardt RT, Schowen RL. Contributions of active site residues to the partial and overall catalytic activities of human S-adenosylhomocysteine hydrolase. Biochemistry. 41: 8134-42. PMID 12069606 DOI: 10.1021/Bi025771P |
0.288 |
|
| 2003 |
Xie M, Shahrokh Z, Kadkhodayan M, Henzel WJ, Powell MF, Borchardt RT, Schowen RL. Asparagine deamidation in recombinant human lymphotoxin: hindrance by three-dimensional structures. Journal of Pharmaceutical Sciences. 92: 869-80. PMID 12661072 DOI: 10.1002/Jps.10342 |
0.288 |
|
| 2005 |
Li B, Gorman EM, Moore KD, Williams T, Schowen RL, Topp EM, Borchardt RT. Effects of acidic N + 1 residues on asparagine deamidation rates in solution and in the solid state. Journal of Pharmaceutical Sciences. 94: 666-75. PMID 15668945 DOI: 10.1002/Jps.20263 |
0.287 |
|
| 1983 |
Matuszewska B, Borchardt RT. Guinea pig brain histamine N-methyltransferase: purification and partial characterization. Journal of Neurochemistry. 41: 113-8. PMID 6864213 DOI: 10.1111/J.1471-4159.1983.Tb11821.X |
0.287 |
|
| 1996 |
Gangwar S, Jois SDS, Siahaan TJ, Vander Velde DG, Stella VJ, Borchardt RT. The effect of conformation on membrane permeability of an acyloxyalkoxy-linked cyclic prodrug of a model hexapeptide Pharmaceutical Research. 13: 1657-1662. PMID 8956330 DOI: 10.1023/A:1016484522113 |
0.286 |
|
| 1997 |
Nerurkar MM, Rose MJ, Stobaugh JF, Borchardt RT. Selective fluorogenic derivatization of a peptide nucleic acid trimer with naphthalene-2,3-dicarboxaldehyde. Journal of Pharmaceutical and Biomedical Analysis. 15: 945-50. PMID 9160260 DOI: 10.1016/S0731-7085(96)01927-9 |
0.286 |
|
| 1994 |
Oliyai C, Patel JP, Carr L, Borchardt RT. Chemical pathways of peptide degradation. VII. Solid state chemical instability of an aspartyl residue in a model hexapeptide. Pharmaceutical Research. 11: 901-8. PMID 7937533 DOI: 10.1023/A:1018998312503 |
0.286 |
|
| 2010 |
Cai S, Fang J, Li QS, Borchardt RT, Kuczera K, Middaugh CR, Schowen RL. Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 3. Role of lysyl and tyrosyl residues of the C-terminal extension. Biochemistry. 49: 8434-41. PMID 20687591 DOI: 10.1021/Bi1007595 |
0.286 |
|
| 1999 |
Grunewald GL, Caldwell TM, Li Q, Slavica M, Criscione KR, Borchardt RT, Wang W. Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. Journal of Medicinal Chemistry. 42: 3588-601. PMID 10479290 DOI: 10.1021/Jm990045E |
0.286 |
|
| 1986 |
Rim S, Audus KL, Borchardt RT. Relationship of octanol/buffer and octanol/water partition coefficients to transcellular diffusion across brain microvessel endothelial cell monolayers International Journal of Pharmaceutics. 32: 79-84. DOI: 10.1016/0378-5173(86)90101-8 |
0.286 |
|
| 1989 |
Scriba GK, Borchardt RT. Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by bovine brain microvessel endothelial cells. Brain Research. 501: 175-8. PMID 2804693 DOI: 10.1016/0006-8993(89)91039-1 |
0.285 |
|
| 1974 |
Borchardt RT, Wu YS. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 1. Modification of the amino acid portion of S-adenosylhomocysteine. Journal of Medicinal Chemistry. 17: 862-8. PMID 4845379 DOI: 10.1021/Jm00254A016 |
0.284 |
|
| 2004 |
Stotz CE, Borchardt RT, Middaugh CR, Siahaan TJ, Vander Velde D, Topp EM. Secondary structure of a dynamic type I' β-hairpin peptide Journal of Peptide Research. 63: 371-382. PMID 15102055 DOI: 10.1111/J.1399-3011.2004.00129.X |
0.283 |
|
| 2006 |
Wakankar AA, Borchardt RT. Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization. Journal of Pharmaceutical Sciences. 95: 2321-36. PMID 16960822 DOI: 10.1002/Jps.20740 |
0.283 |
|
| 1998 |
Artursson P, Borchardt RT. Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond. Pharmaceutical Research. 14: 1655-8. PMID 9453050 DOI: 10.1023/A:1012155124489 |
0.283 |
|
| 1990 |
Cools M, Hasobe M, De Clercq E, Borchardt RT. Mechanism of the synergistic antiviral and cytostatic activity of (RS)-3-(adenin-9-yl)-2-hydroxypropanoic acid isobutyl ester and D,L-homocysteine. Biochemical Pharmacology. 39: 195-202. PMID 2297354 DOI: 10.1016/0006-2952(90)90665-8 |
0.283 |
|
| 2007 |
Wakankar AA, Borchardt RT, Eigenbrot C, Shia S, Wang YJ, Shire SJ, Liu JL. Aspartate isomerization in the complementarity-determining regions of two closely related monoclonal antibodies. Biochemistry. 46: 1534-44. PMID 17279618 DOI: 10.1021/Bi061500T |
0.282 |
|
| 1998 |
Goolcharran C, Borchardt RT. Kinetics of diketopiperazine formation using model peptides. Journal of Pharmaceutical Sciences. 87: 283-8. PMID 9523979 DOI: 10.1021/Js970325M |
0.282 |
|
| 1994 |
Guan X, Borchardt RT. A convenient method for the synthesis of indole-3-acetic acids Tetrahedron Letters. 35: 3013-3016. DOI: 10.1016/S0040-4039(00)76815-8 |
0.282 |
|
| 2005 |
Wang M, Borchardt RT, Schowen RL, Kuczera K. Domain motions and the open-to-closed conformational transition of an enzyme: a normal mode analysis of S-adenosyl-L-homocysteine hydrolase. Biochemistry. 44: 7228-39. PMID 15882061 DOI: 10.1021/Bi047524M |
0.281 |
|
| 1989 |
Wolfe MS, Borcherding DR, Borchardt RT. A 9-step enantiospecific synthesis of (-)-aristeromycin from D-ribonic acid γ-lactone Tetrahedron Letters. 30: 1453-1456. DOI: 10.1016/S0040-4039(00)99488-7 |
0.281 |
|
| 1982 |
Borchardt RT. Catechol O-methyltransferase. Methods in Enzymology. 77: 267-72. PMID 7329304 DOI: 10.1016/S0076-6879(81)77036-8 |
0.279 |
|
| 2008 |
Wnuk SF, Sacasa PR, Lewandowska E, Andrei D, Cai S, Borchardt RT. Synthesis of 5'-functionalized nucleosides: S-Adenosylhomocysteine analogues with the carbon-5' and sulfur atoms replaced by a vinyl or halovinyl unit. Bioorganic & Medicinal Chemistry. 16: 5424-33. PMID 18457953 DOI: 10.1016/J.Bmc.2008.04.017 |
0.279 |
|
| 1992 |
Liu S, Wolfe MS, Borchardt RT. Rational approaches to the design of antiviral agents based on S-adenosyl-L-homocysteine hydrolase as a molecular target. Antiviral Research. 19: 247-65. PMID 1444329 DOI: 10.1016/0166-3542(92)90083-H |
0.278 |
|
| 1988 |
Sinhababu AK, Borchardt RT. Independent synthesis of 5-hydroxytryptamine-4,7-dione - the neurocytotoxic product of autoxidation of 5,7-dihydroxytryptamine Journal of Heterocyclic Chemistry. 25: 1155-1159. DOI: 10.1002/Jhet.5570250422 |
0.276 |
|
| 1982 |
Pugh CS, Borchardt RT. Effects of S-adenosylhomocysteine analogues on vaccinia viral messenger ribonucleic acid synthesis and methylation. Biochemistry. 21: 1535-41. PMID 6282307 DOI: 10.1021/Bi00536A011 |
0.276 |
|
| 1987 |
Audus KL, Borchardt RT. Bovine brain microvessel endothelial cell monolayers as model system for the blood-brain barrier Annals of the New York Academy of Sciences. 507: 9-18. PMID 3442370 DOI: 10.1111/J.1749-6632.1987.Tb45787.X |
0.276 |
|
| 2002 |
Miles RW, Nielsen LP, Ewing GJ, Yin D, Borchardt RT, Robins MJ. S-homoadenosyl-L-cysteine and S-homoadenosyl-L-homocysteine. Synthesis and binding studies of hon-hydrolyzed substrate analogues with S-adenosyl-L-homocysteine hydrolase. The Journal of Organic Chemistry. 67: 8258-60. PMID 12423165 DOI: 10.1021/Jo020478G |
0.276 |
|
| 2000 |
Khossravi M, Shire SJ, Borchardt RT. Evidence for the involvement of histidine A(12) in the aggregation and precipitation of human relaxin induced by metal-catalyzed oxidation. Biochemistry. 39: 5876-85. PMID 10801339 DOI: 10.1021/Bi9924720 |
0.276 |
|
| 1983 |
Borchardt RT, Baranczyk-Kuzma A, Pinnick CL. An Ecteola-cellulose chromatography assay for 3'-phosphoadenosine 5'-phosphosulfate: phenol sulfotransferase. Analytical Biochemistry. 130: 334-8. PMID 6575625 DOI: 10.1016/0003-2697(83)90596-1 |
0.274 |
|
| 2005 |
Wang M, Zhang J, Andrei D, Kuczera K, Borchardt RT, Wnuk SF. Are L-adenosine and its derivatives substrates for S-adenosyl-L-homocysteine hydrolase? Journal of Medicinal Chemistry. 48: 3649-53. PMID 15887973 DOI: 10.1021/Jm0490484 |
0.274 |
|
| 1983 |
Sinhababu AK, Borchardt RT. Selective Ring Omethylation of Hydroxybenzaldehydes Via Their Mannich Bases Synthetic Communications. 13: 677-683. DOI: 10.1002/Chin.198352112 |
0.273 |
|
| 1973 |
Borchardt RT. Catechol O-methyltransferase. 4. In vitro inhibition by 3-hydroxy-4-pyrones, 3-hydroxy-2-pyridones, and 3-hydroxy-4-pyridones. Journal of Medicinal Chemistry. 16: 581-3. PMID 4718481 DOI: 10.1021/Jm00263A047 |
0.273 |
|
| 1993 |
Yuan CS, Yeh J, Squier TC, Rawitch A, Borchardt RT. Ligand-dependent changes in intrinsic fluorescence of S-adenosylhomocysteine hydrolase: implications for the mechanism of inhibitor-induced inhibition. Biochemistry. 32: 10414-22. PMID 8399185 DOI: 10.1021/Bi00090A017 |
0.272 |
|
| 1983 |
Wu SE, Huskey WP, Borchardt RT, Schowen RL. Chiral instability at sulfur of S-adenosylmethionine. Biochemistry. 22: 2828-32. PMID 6871165 DOI: 10.1021/Bi00281A009 |
0.272 |
|
| 1987 |
Kawase M, Sinhababu AK, Borchardt RT. Silica gel assisted reductive cyclization of 2-nitro-β-piperidinostyrenes, derived from 2-nitrotoluenes, to indoles Journal of Heterocyclic Chemistry. 24: 1499-1501. DOI: 10.1002/Jhet.5570240602 |
0.272 |
|
| 1994 |
Yuan CS, Liu S, Wnuk SF, Robins MJ, Borchardt RT. Mechanism of inactivation of S-adenosylhomocysteine hydrolase by (E)-5',6'-didehydro-6'-deoxy-6'-halohomoadenosines. Biochemistry. 33: 3758-65. PMID 8142376 DOI: 10.1021/Bi00178A036 |
0.271 |
|
| 1996 |
Borchardt RT, Smith PL, Wilson G. General principles in the characterization and use of model systems for biopharmaceutical studies. Pharmaceutical Biotechnology. 8: 1-11. PMID 8791801 DOI: 10.1007/978-1-4899-1863-5_1 |
0.271 |
|
| 1982 |
Eiden LE, Borchardt RT, Rutledge CO. Characteristics of protein carboxyl methylation in the rat hypothalamus. Journal of Neurochemistry. 38: 631-7. PMID 7057183 DOI: 10.1111/J.1471-4159.1982.Tb08677.X |
0.271 |
|
| 1983 |
Sinhababu AK, Borchardt RT. Silica gel-assisted reduction of nitrostyrenes to 2-aryl-2-[2H]-1-nitroethanes with sodium borodeuteride Journal of Labelled Compounds and Radiopharmaceuticals. 20: 1027-1033. DOI: 10.1002/Jlcr.2580200814 |
0.271 |
|
| 1988 |
Narayanan SR, Keller BT, Borcherding DR, Scholtz SA, Borchardt RT. 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl) derivatives of adenine and 3-deazaadenine: potent inhibitors of bovine liver S-adenosylhomocysteine hydrolase. Journal of Medicinal Chemistry. 31: 500-3. PMID 3346868 DOI: 10.1021/Jm00398A002 |
0.27 |
|
| 2006 |
Wang M, Unruh JR, Johnson CK, Kuczera K, Schowen RL, Borchardt RT. Effects of ligand binding and oxidation on hinge-bending motions in S-adenosyl-L-homocysteine hydrolase. Biochemistry. 45: 7778-86. PMID 16784229 DOI: 10.1021/Bi0523106 |
0.269 |
|
| 2003 |
Wnuk SF, Sacasa PR, Crain LN, Lewandowska E, Zhang J, Borchardt RT. Stereocontrolled synthesis of diene and enyne sugar-modified nucleosides and their interaction with S-adenosyl-L-homocysteine hydrolase. Nucleosides, Nucleotides & Nucleic Acids. 22: 783-5. PMID 14565278 DOI: 10.1081/Ncn-120022634 |
0.269 |
|
| 2000 |
Yin D, Yang X, Hu Y, Kuczera K, Schowen RL, Borchardt RT, Squier TC. Substrate binding stabilizes S-adenosylhomocysteine hydrolase in a closed conformation. Biochemistry. 39: 9811-8. PMID 10933798 DOI: 10.1021/Bi000595A |
0.269 |
|
| 2000 |
Lai MC, Schowen RL, Borchardt RT, Topp EM. Deamidation of a model hexapeptide in poly(vinyl alcohol) hydrogels and xerogels. The Journal of Peptide Research : Official Journal of the American Peptide Society. 55: 93-101. PMID 10784025 DOI: 10.1034/J.1399-3011.2000.00156.X |
0.269 |
|
| 2011 |
Borchardt RT. Hidalgo, I. J., Raub, T. J., and Borchardt, R. T.: Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability, Gastroenterology, 96, 736-749, 1989--the backstory. The Aaps Journal. 13: 323-7. PMID 21607810 DOI: 10.1208/S12248-011-9283-8 |
0.269 |
|
| 1990 |
SHAH P, HIDALGO I, BORCHARDT R. A simple diffusion device to study transport across cells cultured on microporous membranes International Journal of Pharmaceutics. 63: 281-283. DOI: 10.1016/0378-5173(90)90135-Q |
0.268 |
|
| 2002 |
Wnuk SF, Ro BO, Valdez CA, Lewandowska E, Valdez NX, Sacasa PR, Yin D, Zhang J, Borchardt RT, De Clercq E. Sugar-modified conjugated diene analogues of adenosine and uridine: synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects. Journal of Medicinal Chemistry. 45: 2651-8. PMID 12036374 DOI: 10.1021/Jm020064F |
0.267 |
|
| 1995 |
Hillgren KM, Kato A, Borchardt RT. In vitro systems for studying intestinal drug absorption. Medicinal Research Reviews. 15: 83-109. PMID 7537838 DOI: 10.1002/Med.2610150202 |
0.267 |
|
| 1990 |
Mashhood Ali S, Ramesh K, Borchardt RT. Efficient enantioselective syntheses of carbocyclic nucleoside and prostaglandin synthons Tetrahedron Letters. 31: 1509-1512. DOI: 10.1016/0040-4039(90)80002-4 |
0.267 |
|
| 1973 |
Borchardt RT. Catechol O-methyltransferase. 2. In vitro inhibition by substituted 8-hydroxyquinolines. Journal of Medicinal Chemistry. 16: 382-7. PMID 4736750 DOI: 10.1021/Jm00262A016 |
0.267 |
|
| 1978 |
Pugh CS, Borchardt RT, Stone HO. Simultaneous assay for mRNA (guanine-7-)-methyltransferase and mRNA(2'-O-nucleoside)methyltransferase of purified vaccinia (WR) virions. Analytical Biochemistry. 88: 504-12. PMID 697020 DOI: 10.1016/0003-2697(78)90450-5 |
0.266 |
|
| 2000 |
Li R, D'Souza AJ, Laird BB, Schowen RL, Borchardt RT, Topp EM. Effects of solution polarity and viscosity on peptide deamidation. The Journal of Peptide Research : Official Journal of the American Peptide Society. 56: 326-34. PMID 11095186 DOI: 10.1034/J.1399-3011.2000.00783.X |
0.266 |
|
| 1999 |
Lai MC, Hageman MJ, Schowen RL, Borchardt RT, Laird BB, Topp EM. Chemical stability of peptides in polymers. 2. Discriminating between solvent and plasticizing effects of water on peptide deamidation in poly(vinylpyrrolidone). Journal of Pharmaceutical Sciences. 88: 1081-9. PMID 10514359 DOI: 10.1021/Js9802289 |
0.265 |
|
| 1990 |
Kawase M, Sinhababu AK, McGhee EM, Milby T, Borchardt RT. Synthesis and biological evaluation of 4-fluoro-, 7-fluoro-, and 4,7-difluoro-5,6-dihydroxytryptamines. Journal of Medicinal Chemistry. 33: 2204-11. PMID 2100997 DOI: 10.1021/Jm00170A026 |
0.264 |
|
| 1996 |
Audus KL, Ng L, Wang W, Borchardt RT. Brain microvessel endothelial cell culture systems Pharmaceutical Biotechnology. 8: 239-258. PMID 8791813 DOI: 10.1007/978-1-4899-1863-5_13 |
0.264 |
|
| 1996 |
Xie M, Vander Velde D, Morton M, Borchardt RT, Schowen RL. pH-induced change in the rate-determining step for the hydrolysis of the Asp/Asn-derived cyclic-imide intermediate in protein degradation Journal of the American Chemical Society. 118: 8955-8956. DOI: 10.1021/Ja9606182 |
0.264 |
|
| 1995 |
Imadul I, Hinshaw RR, Chong KT, Kato A, Borchardt RT, Fisher JF. Synthesis and antiviral activity of [2-[[4-[3-[(1-methylethyl)amino]-2-pyridyl]-1 -piperazinyl]carbonyl]1H-indol-5-yl] (BHAP) acylsphingosine HIV reverse transcriptase inhibitors Bioorganic Chemistry. 23: 499-511. DOI: 10.1006/Bioo.1995.1035 |
0.263 |
|
| 1990 |
Amsberry KL, Borchardt RT. The lactonization of 2'-hydroxyhydrocinnamic acid amides: a potential prodrug for amines The Journal of Organic Chemistry. 55: 5867-5877. DOI: 10.1021/Jo00310A019 |
0.262 |
|
| 1992 |
Baranczyk-Kuzma A, Audus KL, Guillot FL, Borchardt RT. Effects of selected vasoactive substances on adenylate cyclase activity in brain, isolated brain microvessels, and primary cultures of brain microvessel endothelial cells Neurochemical Research. 17: 209-214. PMID 1311435 DOI: 10.1007/Bf00966802 |
0.262 |
|
| 1992 |
Hidalgo IJ, Grass GM, Hillgren KM, Borchardt RT. A new side-by-side diffusion cell for studying transport across epithelial cell monolayers. In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association. 578-80. PMID 1429356 DOI: 10.1007/Bf02631026 |
0.261 |
|
| 1997 |
Li S, Patapoff TW, Nguyen TH, Borchardt RT. Inhibitory effect of sugars and polyols on the metal-catalyzed oxidation of human relaxin. Journal of Pharmaceutical Sciences. 85: 868-72. PMID 8863279 DOI: 10.1021/Js9504550 |
0.261 |
|
| 1985 |
Sinhababu AK, Bartel RL, Pochopin N, Borchardt RT. Mechanism of action of S-adenosyl-L-homocysteine hydrolase. Measurement of kinetic isotope effects using adenosine-3'-d and S-adenosyl-L-homocysteine-3'-d as substrates Journal of the American Chemical Society. 107: 7628-7632. DOI: 10.1002/Chin.198613091 |
0.261 |
|
| 2012 |
Li S, Schöneich C, Borchardt RT. Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization. Biotechnology and Bioengineering. 48: 490-500. PMID 18623513 DOI: 10.1002/Bit.260480511 |
0.261 |
|
| 1988 |
Sinhababu AK, Borchardt RT. Molecular mechanism of biological action of the serotonergic neurotoxin 5,7-dihydroxytryptamine. Neurochemistry International. 12: 273-84. PMID 20501230 DOI: 10.1016/0197-0186(88)90165-9 |
0.26 |
|
| 1974 |
Borchardt RT. A rapid spectrophotometric assay for catechol-O-methyltransferase. Analytical Biochemistry. 58: 382-9. PMID 4827387 DOI: 10.1016/0003-2697(74)90206-1 |
0.259 |
|
| 1976 |
Borchardt RT, Wu Y. S-Aristeromycinyl-L-homocysteine, a potent inhibitor of S-adenosylmethionine-dependent transmethylations. Journal of Medicinal Chemistry. 19: 197-8. PMID 1246047 DOI: 10.1021/Jm00223A043 |
0.258 |
|
| 1993 |
Barańczyk-Kuźma A, Audus KL, Borchardt RT. Sulfation of catecholamines, hypertensive and hypotensive drugs by monkey brain cortex enzymes. Acta Biochimica Polonica. 40: 189-192. DOI: 10.18388/Abp.1993_4887 |
0.258 |
|
| 2000 |
Xie M, Aubé J, Borchardt RT, Morton M, Topp EM, Vander Velde D, Schowen RL. Reactivity toward deamidation of asparagine residues in beta-turn structures. The Journal of Peptide Research : Official Journal of the American Peptide Society. 56: 165-71. PMID 11007273 DOI: 10.1034/J.1399-3011.2000.00764.X |
0.258 |
|
| 1982 |
Sinhababu AK, Borchardt RT. An Efficient Method for the Conversion of Phenolic Mannich Bases to C-Methylated Phenols. Synthesis of 3,6-Dimethylcatechol Synthetic Communications. 12: 983-988. DOI: 10.1002/Chin.198326161 |
0.257 |
|
| 1983 |
Sinhababu AK, Borchardt RT. Silica gel-assisted reduction of nitrostyrenes to 2-aryl-1-nitroalkanes with sodium borohydride Tetrahedron Letters. 24: 227-230. DOI: 10.1016/S0040-4039(00)81371-4 |
0.257 |
|
| 1991 |
Audus KL, Borchardt RT. Transport of Macromolecules Across the Capillary Endothelium Handbook of Experimental Pharmacology. 100: 43-70. DOI: 10.1007/978-3-642-75862-1_3 |
0.256 |
|
| 1981 |
Borchardt RT, Sinhababu AK. Efficient synthesis of 3,5-dihydroxy-4-methylbenzoic acid The Journal of Organic Chemistry. 46: 5021-5022. DOI: 10.1021/Jo00337A046 |
0.256 |
|
| 1990 |
Wolfe MS, Anderson BL, Borcherding DR, Borchardt RT. Enantiospecific syntheses of aristeromycin and neplanocin A The Journal of Organic Chemistry. 55: 4712-4717. DOI: 10.1021/Jo00302A043 |
0.255 |
|
| 2002 |
Yang JZ, Bastian KC, Moore RD, Stobaugh JF, Borchardt RT. Quantitative analysis of a model opioid peptide and its cyclic prodrugs in rat plasma using high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 780: 269-81. PMID 12401352 DOI: 10.1016/S1570-0232(02)00536-6 |
0.255 |
|
| 1999 |
Lai MC, Hageman MJ, Schowen RL, Borchardt RT, Topp EM. Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly(vinyl alcohol) and poly(vinyl pyrrolidone) matrixes. Journal of Pharmaceutical Sciences. 88: 1073-80. PMID 10514358 DOI: 10.1021/Js980227G |
0.255 |
|
| 1975 |
Borchardt RT, Huber JA. Catechol O-methyltransferase. 5. Structure-activity relationships for inhibition by flavonoids Journal of Medicinal Chemistry. 18: 120-122. PMID 1109569 DOI: 10.1021/Jm00235A030 |
0.254 |
|
| 1983 |
Sinhababu AK, Borchardt RT. General method for the synthesis of phthalaldehydic acids and phthalides from o-bromobenzaldehydes via ortho-lithiated aminoalkoxides The Journal of Organic Chemistry. 48: 2356-2360. DOI: 10.1021/Jo00162A011 |
0.254 |
|
| 2004 |
Wnuk SF, Lewandowska E, Sacasa PR, Crain LN, Zhang J, Borchardt RT, De Clercq E. Stereoselective synthesis of sugar-modified enyne analogues of adenosine and uridine. Interaction with S-adenosyl-L-homocysteine hydrolase and antiviral and cytotoxic effects. Journal of Medicinal Chemistry. 47: 5251-7. PMID 15456269 DOI: 10.1021/Jm040054+ |
0.254 |
|
| 1987 |
Sinhababu AK, Kawase M, Borchardt RT. tert-Butyldimethylsilyl ethers of phenols: Their one-step conversion to benzyl or methyl ethers and utility in regioselective ortho lithiation Tetrahedron Letters. 28: 4139-4142. DOI: 10.1016/S0040-4039(00)95560-6 |
0.254 |
|
| 1987 |
Borcherding DR, Scholtz SA, Borchardt RT. Synthesis of analogs of neplanocin A: utilization of optically active dihydroxycyclopentenones derived from carbohydrates The Journal of Organic Chemistry. 52: 5457-5461. DOI: 10.1021/Jo00233A029 |
0.254 |
|
| 1973 |
BORCHARDT RT, COHEN LA. ChemInform Abstract: STEREOPOPULATIONS-KONTROLLE 2. MITT. GESCHWINDIGKEITSERHOEHUNG BEI DER INTRAMOLEKULAREN NUCLEOPHILEN SUBSTITUTION Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197310154 |
0.253 |
|
| 1973 |
Borchardt RT. Catechol O-methyltransferase. 3. Mechanism of pyridoxal 5'-phosphate inhibition. Journal of Medicinal Chemistry. 16: 387-91. PMID 4736751 DOI: 10.1021/Jm00262A017 |
0.253 |
|
| 2002 |
Tang F, Horie K, Borchardt RT. Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharmaceutical Research. 19: 765-72. PMID 12134945 DOI: 10.1023/A:1016140429238 |
0.253 |
|
| 1989 |
Paisley SD, Wolfe MS, Borchardt RT. Oxidation of neplanocin A to the corresponding 3'-keto derivative by S-adenosylhomocysteine hydrolase. Journal of Medicinal Chemistry. 32: 1415-8. PMID 2738875 DOI: 10.1021/Jm00127A001 |
0.253 |
|
| 1978 |
Borchardt RT, Wu YS, Wu BS. Mechanism of inhibition of pineal hydroxyindole-O-methyltransferase by pyridoxal 5'-phosphate. Biochemical Pharmacology. 27: 120-2. PMID 619896 DOI: 10.1016/0006-2952(78)90268-X |
0.252 |
|
| 1995 |
Borchardt R. The Application of Cell Culture Systems in Drug Discovery and Development Journal of Drug Targeting. 3: 179-182. PMID 8705249 DOI: 10.3109/10611869509015942 |
0.251 |
|
| 1982 |
Bradberry CW, Borchardt RT, Decedue CJ. Immobilization of ascorbic acid oxidase Febs Letters. 146: 348-352. DOI: 10.1016/0014-5793(82)80950-2 |
0.25 |
|
| 1986 |
Borchardt RT. Enzyme Chemistry: Impact and Applications Journal of Pharmaceutical Sciences. 75: 220. DOI: 10.1002/Jps.2600750228 |
0.25 |
|
| 1992 |
Ramesh K, Wolfe MS, Lee Y, Vander Velde D, Borchardt RT. Synthesis of hydroxylated cyclohexenyl- and cyclohexanyladenines as potential inhibitors of S-adenosylhomocysteine hydrolase The Journal of Organic Chemistry. 57: 5861-5868. DOI: 10.1021/Jo00048A018 |
0.249 |
|
| 1984 |
Wu SE, Huskey WP, Borchardt RT, Schowen RL. Different isotope effects for parallel pathways of enzyme-catalyzed transmethylation Journal of the American Chemical Society. 106: 5762-5763. DOI: 10.1021/Ja00331A075 |
0.249 |
|
| 1983 |
Moorman AR, Martin T, Borchardt RT. Addition of 1-nitroalkanes to methyl 2,3-O-isopropylidene-β-d-ribo-pentodialdo-1,4-furanoside and N6-benzoyl-2′,3′-O-isopropylideneadenosine-5′-aldehyde Carbohydrate Research. 113: 233-239. DOI: 10.1002/Chin.198334337 |
0.249 |
|
| 1991 |
Takakura Y, Kuentzel SL, Raub TJ, Davies A, Baldwin SA, Borchardt RT. Hexose uptake in primary cultures of bovine brain microvessel endothetial cells. I. Basic characteristics and effects of d-glucose and insulin Bba - Biomembranes. 1070: 1-10. PMID 1751515 DOI: 10.1016/0005-2736(91)90139-Y |
0.249 |
|
| 1989 |
Hidalgo IJ, Kato A, Borchardt RT. Binding of epidermal growth factor by human colon carcinoma cell (Caco-2) monolayers. Biochemical and Biophysical Research Communications. 160: 317-24. PMID 2785387 DOI: 10.1016/0006-291X(89)91658-6 |
0.249 |
|
| 1979 |
Borchardt RT. Mechanism of alkaline hydrolysis of S-adenosyl-L-methionine and related sulfonium nucleosides Journal of the American Chemical Society. 101: 458-463. DOI: 10.1021/Ja00496A032 |
0.248 |
|
| 1977 |
Borchardt RT, Vincek WC, Grunewald GL. A liquid chromatographic assay for phenylethanolamine N-methyltransferase. Analytical Biochemistry. 82: 149-57. PMID 907119 DOI: 10.1016/0003-2697(77)90143-9 |
0.248 |
|
| 1974 |
BORCHARDT RT, COHEN LA. ChemInform Abstract: STEREOPOPULATION CONTROL PART 5, FACILITATION OF INTRAMOLECULAR CONJUGATE ADDITION OF AN ALDEHYDE HYDRATE AND HEMIACETAL Chemischer Informationsdienst. 5: no-no. DOI: 10.1002/Chin.197409137 |
0.247 |
|
| 1973 |
Borchardt RT. Catechol O-methyltransferase. 1. Kinetics of tropolone inhibition. Journal of Medicinal Chemistry. 16: 377-82. PMID 4736749 DOI: 10.1021/Jm00262A015 |
0.247 |
|
| 1978 |
Borchardt RT, Olsen J, Eiden L, Schowen RL, Rutledge CO. The isolation and characterization of the methyl acceptor protein from adrenal chromaffin granules. Biochemical and Biophysical Research Communications. 83: 970-6. PMID 708445 DOI: 10.1016/0006-291X(78)91490-0 |
0.246 |
|
| 1976 |
Borchardt RT. Inhibition of indolethylamine-N-methyltransferase by analogs of S-adenosylhomocysteine. Biochemical Pharmacology. 24: 1542-4. PMID 1191406 DOI: 10.1016/0006-2952(75)90035-0 |
0.246 |
|
| 1976 |
Borchardt RT, Huber JA, Wu YS. A convenient preparation of S-adenosylhomocysteine and related compounds Journal of Organic Chemistry. 41: 565-567. PMID 1245911 DOI: 10.1002/Chin.197619392 |
0.245 |
|
| 1990 |
Kawase M, Sinhababu AK, Borchardt RT. Mechanism of autoxidation of 5,7-dihydroxytryptamine: effect of fluorine substitution at positions 4 and/or 6. Chemical & Pharmaceutical Bulletin. 38: 2939-46. PMID 2085877 DOI: 10.1248/Cpb.38.2939 |
0.245 |
|
| 2003 |
Horie K, Tang F, Borchardt RT. Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter. Pharmaceutical Research. 20: 161-8. PMID 12636153 DOI: 10.1023/A:1022359300826 |
0.244 |
|
| 1991 |
Shah PK, Bartel RL, Borchardt RT. Permeability characteristics of cultured mouse keratinocytes compared to hairless mouse skin International Journal of Pharmaceutics. 68: 285-288. DOI: 10.1016/0378-5173(91)90152-E |
0.244 |
|
| 2001 |
Song Y, Schowen RL, Borchardt RT, Topp EM. Effect of 'pH' on the rate of asparagine deamidation in polymeric formulations: 'pH'-rate profile. Journal of Pharmaceutical Sciences. 90: 141-56. PMID 11169531 DOI: 10.1002/1520-6017(200102)90:2<141::Aid-Jps5>3.0.Co;2-Y |
0.243 |
|
| 1974 |
BORCHARDT RT, COHEN LA. ChemInform Abstract: STEREOPOPULATION CONTROL PART 4, FACILITATION OF INTRAMOLECULAR CONJUGATE ADDITION OF THE HYDROXYL GROUP Chemischer Informationsdienst. 5: no-no. DOI: 10.1002/Chin.197409136 |
0.243 |
|
| 2008 |
Hu C, Fang J, Borchardt RT, Schowen RL, Kuczera K. Molecular dynamics simulations of domain motions of substrate-free S-adenosyl- L-homocysteine hydrolase in solution. Proteins. 71: 131-43. PMID 17932938 DOI: 10.1002/Prot.21664 |
0.242 |
|
| 1988 |
Rosenfeld RG, Pham H, Keller BT, Borchardt RT, Pardridge WM. Demonstration and structural comparison of receptors for insulin-like growth factor-I and -II (IGF-I and -II) in brain and blood-brain barrier. Biochemical and Biophysical Research Communications. 149: 159-66. PMID 2961336 DOI: 10.1016/0006-291X(87)91618-4 |
0.24 |
|
| 1973 |
BORCHARDT RT, COHEN LA. ChemInform Abstract: STEREOPOPULATIONS-KONTROLLE 3. MITT. ERLEICHTERUNG DER INTRAMOLEKULAREN KONJUGIERTEN ADDITION DER CARBOXYLGRUPPE Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197311144 |
0.24 |
|
| 1979 |
Hegazi MF, Borchardt RT, Schowen RL. .alpha.-Deuterium and carbon-13 isotope effects for methyl transfer catalyzed by catechol O-methyltransferase. SN2-like transition state Journal of the American Chemical Society. 101: 4359-4365. DOI: 10.1021/Ja00509A052 |
0.239 |
|
| 1990 |
Manning MC, Patel K, Borchardt RT. Stability of protein pharmaceuticals. Pharmaceutical Research. 6: 903-18. PMID 2687836 DOI: 10.1023/A:1015929109894 |
0.239 |
|
| 1973 |
Borchardt RT, Cohen LA. Stereopopulation control. V. Facilitation on intramolecular conjugate addition of an aldehyde hydrate and hemiacetal Journal of the American Chemical Society. 95: 8313-8319. DOI: 10.1021/Ja00806A019 |
0.238 |
|
| 1980 |
Borchardt RT. S-Adenosyl-L-methionine-dependent macromolecule methyltransferases: potential targets for the design of chemotherapeutic agents. Journal of Medicinal Chemistry. 23: 347-57. PMID 6991690 DOI: 10.1002/Chin.198035352 |
0.237 |
|
| 1993 |
Stevenson CL, Anderegg RJ, Borchardt RT. Comparison of separation and detection techniques for human growth hormone releasing factor (hGRF) and the products derived from deamidation. Journal of Pharmaceutical and Biomedical Analysis. 11: 367-73. PMID 8357873 DOI: 10.1016/0731-7085(93)80030-5 |
0.236 |
|
| 1985 |
Liang NY, Hower JA, Borchardt RT. Release of endogenous brain epinephrine by the calcium ionophores X537A and A23187. Brain Research. 341: 297-302. PMID 3929996 DOI: 10.1016/0006-8993(85)91068-6 |
0.236 |
|
| 1983 |
Moorman AR, Borchardt RT. Synthesis of methyl 5-O-acetyl-7-deoxy-2,3-O-isopropylidene-heptofuranosid-6-uloses Carbohydrate Research. 119: 269-272. DOI: 10.1016/0008-6215(83)84064-6 |
0.235 |
|
| 2001 |
Wang W, Dentler WL, Borchardt RT. VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly American Journal of Physiology - Heart and Circulatory Physiology. 280. PMID 11123261 DOI: 10.1152/Ajpheart.2001.280.1.H434 |
0.235 |
|
| 1996 |
Takakura Y, Morita T, Fujikawa M, Hayashi M, Sezaki H, Hashida M, Borchardt RT. Characterization of LLC-PK1 kidney epithelial cells as an in vitro model for studying renal tubular reabsorption of protein drugs. Pharmaceutical Research. 12: 1968-72. PMID 8786975 DOI: 10.1023/A:1016256325921 |
0.235 |
|
| 1973 |
Borchardt RT, Cohen LA. Stereopopulation control. 3. Facilitation of intramolecular conjugate addition of the carboxyl group. Journal of the American Chemical Society. 94: 9175-82. PMID 4642367 DOI: 10.1021/Ja00781A031 |
0.235 |
|
| 1989 |
Hasobe M, McKee JG, Borchardt RT. Relationship between intracellular concentration of S-adenosylhomocysteine and inhibition of vaccinia virus replication and inhibition of murine L-929 cell growth. Antimicrobial Agents and Chemotherapy. 33: 828-34. PMID 2764532 DOI: 10.1128/Aac.33.6.828 |
0.234 |
|
| 2002 |
Ouyang H, Borchardt RT, Siahaan TJ. Steric hindrance is a key factor in the coupling reaction of (acyloxy) alkyl-α-halides with phenols to make a new promoiety for prodrugs Tetrahedron Letters. 43: 577-579. DOI: 10.1016/S0040-4039(01)02241-9 |
0.233 |
|
| 1978 |
Borchardt RT, Hegazi MF, Schowen RL. Determination of O-methylated metabolites of cathecholamines using high-performance liquid chromatography and electrochemical detection. Journal of Chromatography. 152: 253-9. PMID 649747 DOI: 10.1016/S0021-9673(00)85363-7 |
0.233 |
|
| 1985 |
Borchardt RT. Mechanism of Drug Action Journal of Pharmaceutical Sciences. 74: 910. DOI: 10.1002/Jps.2600740841 |
0.232 |
|
| 1973 |
Borchardt RT, Cohen LA. Stereopopulation control. VI. Conformational selection of alternative oxidation pathways Journal of the American Chemical Society. 95: 8319-8326. DOI: 10.1021/Ja00806A020 |
0.232 |
|
| 1993 |
Ng KY, Grass G, Lane H, Borchardt RT. Characterization of the unstirred water layer in cultured brain microvessel endothelial cells. In Vitro Cellular & Developmental Biology. Animal. 627-9. PMID 8376313 DOI: 10.1007/Bf02634549 |
0.231 |
|
| 1974 |
Borchardt RT, Cohen LA. Stereopopulation Control Part 6, Conformational Selection Of Alternative Oxidation Pathways Cheminform. 5. DOI: 10.1002/Chin.197409186 |
0.231 |
|
| 1989 |
Scriba GK, Borchardt RT, Zirrolli JA, Fennessey PV. Selected-ion monitoring gas chromatographic-mass spectrometric analysis of catecholamines: enhancement of sensitivity by a simple clean-up step on Sephadex G-10. Journal of Chromatography. 433: 31-40. PMID 2466862 DOI: 10.1016/S0378-4347(00)80582-4 |
0.23 |
|
| 1991 |
Shah PK, Borchardt RT. Liquid chromatographic analysis of leucine-enkephalin and its metabolites in homogenates of cultured human keratinocytes. Journal of Pharmaceutical and Biomedical Analysis. 8: 457-61. PMID 2081209 DOI: 10.1016/0731-7085(90)80076-2 |
0.229 |
|
| 1994 |
Islam I, Ng KY, Chong KT, McQuade TJ, Hui JO, Wilkinson KF, Rush BD, Ruwart MJ, Borchardt RT, Fisher JF. Evaluation of a vitamin-cloaking strategy for oligopeptide therapeutics: biotinylated HIV-1 protease inhibitors. Journal of Medicinal Chemistry. 37: 293-304. PMID 8295217 DOI: 10.1021/jm00028a013 |
0.225 |
|
| 1974 |
Hanna PE, Borchardt RT. Histamine N-methyltransferase. Inhibition and potentiation by trans- and cis-1,5-diphenyl-3-dimethylaminopyrrolidine Journal of Medicinal Chemistry. 17: 741-743. PMID 4830549 DOI: 10.1021/Jm00250A027 |
0.224 |
|
| 1991 |
Wolfe MS, Borchardt RT. S-adenosyl-L-homocysteine hydrolase as a target for antiviral chemotherapy. Journal of Medicinal Chemistry. 34: 1521-30. PMID 2033576 DOI: 10.1021/Jm00109A001 |
0.22 |
|
| 1977 |
Pugh CS, Borchardt RT, Stone HO. Inhibition of Newcastle disease virion messenger RNA (guanine-7-)-methyltransferase by analogues of S-adenosylhomocysteine. Biochemistry. 16: 3928-32. PMID 901760 DOI: 10.1021/Bi00636A032 |
0.218 |
|
| 2011 |
Borchardt RT. It is equally important to mention that the journal's impact as judged by "usage metrics" (i.e., article downloads) continued to grow significantly in 2010. Journal of Pharmaceutical Sciences. 100: 1997-8. PMID 21344416 DOI: 10.1002/Jps.22533 |
0.213 |
|
| 1983 |
Simmons J, Borchardt RT. Regioselective syntheses of deuterium labelled 6-hydroxydopamines Journal of Labelled Compounds and Radiopharmaceuticals. 20: 325-338. DOI: 10.1002/Jlcr.2580200303 |
0.213 |
|
| 1989 |
Sinhababu AK, Borchardt RT. Mechanism of autoxidation of 5,7-dihydroxytryptamine: singlet oxygen-18 is incorporated on C-4 during oxidation with molecular oxygen-18 Journal of the American Chemical Society. 111: 2230-2233. DOI: 10.1021/Ja00188A043 |
0.212 |
|
| 1982 |
Borchardt RT, Simmons JE. General methods for the preparation of α and/OR β deuterium labelled 6-hydroxydopamine derivatives Journal of Labelled Compounds and Radiopharmaceuticals. 19: 433-445. DOI: 10.1002/Jlcr.2580190316 |
0.211 |
|
| 1983 |
Sinhababu AK, Borchardt RT. Aromatic hydroxylation. Hydroxybenzaldehydes from bromobenzaldehydes via reaction of in situ generated, lithiated .alpha.-morpholinobenzyl alkoxides with nitrobenzene The Journal of Organic Chemistry. 48: 1941-1944. DOI: 10.1021/Jo00160A001 |
0.211 |
|
| 1973 |
Borchardt RT, Cohen LA. Stereopopulation control. II. Rate enhancement of intramolecular nucleophilic displacement. Journal of the American Chemical Society. 94: 9166-74. PMID 4642366 DOI: 10.1021/Ja00781A030 |
0.21 |
|
| 1990 |
Votruba I, Hasobe M, Holý A, Borchardt RT. 2-Methylpropyl ester of 3-(adenin-9-yl)-2-hydroxypropanoic acid. Mechanism of antiviral action in vaccinia virus-infected L929 cells. Biochemical Pharmacology. 39: 1573-80. PMID 2337414 DOI: 10.1016/0006-2952(90)90523-N |
0.209 |
|
| 2000 |
Goolcharran C, Cleland JL, Keck R, Jones AJ, Borchardt RT. Comparison of the rates of deamidation, diketopiperazine formation and oxidation in recombinant human vascular endothelial growth factor and model peptides. Aaps Pharmsci. 2: E5. PMID 11741221 DOI: 10.1208/ps020105 |
0.203 |
|
| 2014 |
Borchardt RT. Editorial. Gordon L. Amidon Dedicated Issue. Journal of Pharmaceutical Sciences. 103: 1583. PMID 24756924 DOI: 10.1002/Jps.23981 |
0.202 |
|
| 1983 |
Sinhababu AK, Borchardt RT. Silica gel assisted reductive cyclization of alkoxy-2, .beta.-dinitrostyrenes to alkoxyindoles The Journal of Organic Chemistry. 48: 3347-3349. DOI: 10.1021/Jo00167A045 |
0.201 |
|
| 1985 |
Osiecka I, Porter PA, Borchardt RT, Fix JA, Gardner CR. In Vitro Drug Absorption Models. I. Brush Border Membrane Vesicles, Isolated Mucosal Cells and Everted Intestinal Rings: Characterization and Salicylate Accumulation Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 2: 284-293. DOI: 10.1023/A:1016341601273 |
0.2 |
|
| 1985 |
Sinhababu AK, Borchardt RT. Mechanism and products of autoxidation of 5,7-dihydroxytryptamine Journal of the American Chemical Society. 107: 7618-7627. DOI: 10.1002/Chin.198613122 |
0.199 |
|
| 1990 |
Levy G, Amidon GL, Benet LZ, Borchardt RT, Brouwer KR, Fung HL, Giacomini KM, Kroboth PD, Repta AJ, Robinson JR, Slattery JT, Lee VHL, Breimer D, Sezaki H. Academic pharmaceutics: The challenge of excellence Pharmaceutical Research. 7: 782-785. PMID 2395809 DOI: 10.1023/A:1015844411943 |
0.198 |
|
| 1988 |
Sinhababu AK, Kawase M, Borchardt RT. Desilylation oftert-Butyldimethylsilyl Ethers of Phenols Synthesis. 1988: 710-712. DOI: 10.1055/S-1988-27681 |
0.194 |
|
| 1995 |
Augustijns PF, Ng K, Williams TM, Borchardt RT. Peptidyl Dipeptidase A-Catalyzed Metabolism of Delta Sleep-Inducing Peptide in Bovine Brain Microvessel Endothelial Cells: A Cell Culture Model of the Blood-Brain Barrier Biochemical and Biophysical Research Communications. 210: 987-994. PMID 7763273 DOI: 10.1006/bbrc.1995.1754 |
0.193 |
|
| 2013 |
Borchardt RT. The 2013 Ebert Prize was presented to Professor Benet and his coauthor Dr. Reyes. Journal of Pharmaceutical Sciences. 102: 2910-1. PMID 23592414 DOI: 10.1002/Jps.23555 |
0.193 |
|
| 1997 |
Borchardt RT. Are graduate programs training pharmaceutical scientists to function effectively in the new, highly integrated and globalized pharmaceutical industry? Pharmaceutical Research. 14: 554-5. PMID 9165523 DOI: 10.1023/A:1012184524179 |
0.189 |
|
| 2013 |
Borchardt RT. Professor Benet’s contributions to the pharmaceutical sciences. Journal of Pharmaceutical Sciences. 102: 2909. PMID 23696112 DOI: 10.1002/Jps.23615 |
0.189 |
|
| 2015 |
Borchardt RT. Editorial: 10 most accessed and the 10 most cited papers. Journal of Pharmaceutical Sciences. 104: 1211-2. PMID 25754588 DOI: 10.1002/Jps.24415 |
0.188 |
|
| 1991 |
Amsberry KL, Gerstenberger AE, Borchardt RT. Amine prodrugs which utilize hydroxy amide lactonization. II. A potential esterase-sensitive amide prodrug. Pharmaceutical Research. 8: 455-61. PMID 1871039 DOI: 10.1023/A:1015890809507 |
0.188 |
|
| 1998 |
Borchardt RT. Value of pharmaceutical sciences. Journal of Pharmaceutical and Biomedical Analysis. 16: 1387-401. PMID 9777613 DOI: 10.1016/S0731-7085(97)00165-9 |
0.187 |
|
| 1997 |
Borchardt RT. Value of pharmaceutical sciences. Pharmaceutical Research. 14: 958-66. PMID 9279873 DOI: 10.1023/A:1012176506374 |
0.187 |
|
| 2014 |
Borchardt RT. Editorial: Marcus E. Brewster. Journal of Pharmaceutical Sciences. 103: 3807. PMID 25363141 DOI: 10.1002/Jps.24227 |
0.187 |
|
| 2013 |
Borchardt RT. A comprehensive analysis of the scientific scope of the papers. Journal of Pharmaceutical Sciences. 102: 2-5. PMID 23161071 DOI: 10.1002/Jps.23372 |
0.187 |
|
| 2014 |
Borchardt RT. Editorial: the ten most highly cited articles. Journal of Pharmaceutical Sciences. 103: 2961-2. PMID 25142206 DOI: 10.1002/Jps.24109 |
0.187 |
|
| 2012 |
Borchardt RT. The "Ten Most Highly Cited Articles" and the "Ten Most Frequently Downloaded Articles" in the Journal of Pharmaceutical Sciences. Journal of Pharmaceutical Sciences. 101: 1645-6. PMID 22344820 DOI: 10.1002/Jps.23080 |
0.186 |
|
| 2014 |
Borchardt RT. The Ebert Prize was established in 1873 and it is the oldest pharmacy award in existence in the United States. Journal of Pharmaceutical Sciences. 103: 1929-30. PMID 24797934 DOI: 10.1002/Jps.23993 |
0.185 |
|
| 2012 |
Borchardt RT. Professor Benet is considered by his peers to be one of the “founding fathers” of the modern pharmaceutical sciences. Journal of Pharmaceutical Sciences. 101: 1949. PMID 22430254 DOI: 10.1002/Jps.23124 |
0.184 |
|
| 2008 |
Borchardt RT. Impact of Journal of Pharmaceutical Sciences. Journal of Pharmaceutical Sciences. 97: 1631-2. PMID 18351587 DOI: 10.1002/Jps.21385 |
0.184 |
|
| 2010 |
Borchardt RT. Journal of Pharmaceutical Sciences. Editorial. Journal of Pharmaceutical Sciences. 99: 567. PMID 19938083 DOI: 10.1002/Jps.22049 |
0.182 |
|
| 2018 |
Borchardt RT. Editorial Invitation to Become a Reviewer for the Journal of Pharmaceutical Sciences. Journal of Pharmaceutical Sciences. 107: 1209-1210. PMID 30686296 DOI: 10.1016/J.Xphs.2018.01.028 |
0.181 |
|
| 2004 |
Polli JE, Yu LX, Cook JA, Amidon GL, Borchardt RT, Burnside BA, Burton PS, Chen ML, Conner DP, Faustino PJ, Hawi AA, Hussain AS, Joshi HN, Kwei G, Lee VH, et al. Summary workshop report: biopharmaceutics classification system--implementation challenges and extension opportunities. Journal of Pharmaceutical Sciences. 93: 1375-81. PMID 15124197 DOI: 10.1002/Jps.20064 |
0.181 |
|
| 2011 |
Borchardt RT. This honor is being bestowed on Professor Stella because of his numerous and significant contributions to research, teaching, and service in the pharmaceutical sciences. Journal of Pharmaceutical Sciences. 100: 1999. PMID 21425167 DOI: 10.1002/Jps.22558 |
0.18 |
|
| 1985 |
Porter PA, Osiecka I, Borchardt RT, Fix JA, Frost L, Gardner C. In Vitro Drug Absorption Models. II. Salicylate, Cefoxitin, α-Methyldopa and Theophylline Uptake in Cells and Rings: Correlation with In Vivo Bioavailability Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 2: 293-298. DOI: 10.1023/A:1016393618111 |
0.177 |
|
| 2014 |
Borchardt RT. At the time, Dr. Middaugh was a senior scientist in pharmaceutical research and vaccine development at Merck and Company. Journal of Pharmaceutical Sciences. 103: 351. PMID 24382751 DOI: 10.1002/Jps.23813 |
0.177 |
|
| 2015 |
Borchardt RT. Editorial: JPharmSci annually recognizes peer reviewers (2014). Journal of Pharmaceutical Sciences. 104: 1. PMID 25421602 DOI: 10.1002/Jps.24264 |
0.174 |
|
| 1977 |
Borchardt RT, Wu YS. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 5. Role of the asymmetric sulfonium pole in the enzymatic binding of S-adenosyl-L-methionine. Journal of Medicinal Chemistry. 19: 1099-1103. PMID 978674 DOI: 10.1021/jm00231a004 |
0.171 |
|
| 2010 |
ROBINS MJ, WNUK SF, MULLAH KB, DALLEY NK, YUAN C, LEE Y, BORCHARDT RT. ChemInform Abstract: Nucleic Acid Related Compounds. Part 80. Synthesis of 5′-S-(Alkyl and aryl)-5′-fluoro-5′-thioadenosines with Xenon Difluoride or ( Diethylamido)sulfur Trifluoride, Hydrolysis in Aqueous Buffer, and inhibition of S-Adenosyl-L-homocyste Cheminform. 25: no-no. DOI: 10.1002/chin.199426263 |
0.168 |
|
| 2009 |
Borchardt RT. 2009 Ebert Prize. Editorial. Journal of Pharmaceutical Sciences. 98: 2237. PMID 19475657 DOI: 10.1002/Jps.21829 |
0.167 |
|
| 2014 |
Borchardt RT. The term of these individuals will expire on December 31, 2013. Journal of Pharmaceutical Sciences. 103: 352. PMID 24382800 DOI: 10.1002/Jps.23842 |
0.167 |
|
| 2010 |
WNUK SF, YUAN C, BORCHARDT RT, ROBINS MJ. ChemInform Abstract: Nucleic Acid Related Compounds. Part 99. Synthesis of Homologated Halovinyl Derivatives from Aristeromycin and Their Inhibition of Human Placental S-Adenosyl-L-homocysteine Hydrolase. Cheminform. 29: no-no. DOI: 10.1002/chin.199828272 |
0.166 |
|
| 1985 |
HOUSTON DM, MATUSZEWSKA B, BORCHARDT RT. ChemInform Abstract: POTENTIAL INHIBITORS OF S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES. 10. ASE- AND AMINO ACID MODIFIED ANALOGS OF S-ARISTEROMYCINYL-L-HOMOCYSTEINE Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198531335 |
0.158 |
|
| 1982 |
BORCHARDT RT, HUBER JA, HOUSTON M. ChemInform Abstract: CATECHOL O-METHYLTRANSFERASE. 10. 5-SUBSTITUTED, 3-HYDROXY-4-METHOXYBENZOIC ACIDS (ISOVANILLIC ACIDS) AND 5-SUBSTITUTED, 3-HYDROXY-4-METHOXYBENZALDEHYDES (ISOVANILLINS) AS POTENTIAL INHIBITORS Chemischer Informationsdienst. 13. DOI: 10.1002/chin.198233149 |
0.153 |
|
| 2010 |
RAMESH K, WOLFE MS, LEE Y, VELDE DV, BORCHARDT RT. ChemInform Abstract: Synthesis of Hydroxylated Cyclohexenyl- and Cyclohexanyladenines as Potential Inhibitors of S-Adenosylhomocysteine Hydrolase. Cheminform. 24: no-no. DOI: 10.1002/chin.199309250 |
0.149 |
|
| 1974 |
BORCHARDT RT, WU YS. ChemInform Abstract: POTENTIAL INHIBITORS OF S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES PART 1, MODIFICATION OF THE AMINO ACID PORTION OF S-ADENOSYLHOMOCYSTEINE Chemischer Informationsdienst. 5: no-no. DOI: 10.1002/chin.197447470 |
0.149 |
|
| 2010 |
OLIYAI C, BORCHARDT RT. ChemInform Abstract: Solution and Solid-State Chemical Instabilities of Asparaginyl and Aspartyl Residues in Model Peptides. Cheminform. 26: no-no. DOI: 10.1002/chin.199503301 |
0.147 |
|
| 2010 |
Gangwar S, Pauletti GM, Siahaan TJ, Stella VJ, Borchardt RT. ChemInform Abstract: Synthesis of an Esterase-Sensitive Cyclic Prodrug of a Model Hexapeptide Having Enhanced Membrane Permeability and Enzymatic Stability Using an Acyloxyalkoxy Promoiety Cheminform. 31: no-no. DOI: 10.1002/chin.200032253 |
0.147 |
|
| 2010 |
AMSBERRY KL, BORCHARDT RT. ChemInform Abstract: The Lactonization of 2′-Hydroxyhydrocinnamic Acid Amides: A Potential Prodrug for Amines. Cheminform. 22: no-no. DOI: 10.1002/chin.199116137 |
0.146 |
|
| 1998 |
Robins MJ, Neschadimenko V, Ro BO, Yuan CS, Borchardt RT, Wnuk SF. Nucleic Acid Related Compounds. 101. S-Adenosyl-L-homocysteine Hydrolase Does Not Hydrate (5′-Fluoro)vinyl or (6′-Halo)homovinyl Analogues Derived from 3′-Deoxyadenosine or 3′-(Chloro or Fluoro)-3′-deoxyadenosine Journal of Organic Chemistry. 63: 1205-1211. |
0.145 |
|
| 1983 |
RAFFERTY MF, WILSON DS, MONN JA, KRASS P, BORCHARDT RT, GRUNEWALD GL. ChemInform Abstract: IMPORTANCE OF THE AROMATIC RING IN ADRENERGIC AMINES. 7. COMPARISON OF THE STEREOSELECTIVITY OF NOREPINEPHRINE N-METHYLTRANSFERASE FOR AROMATICS. NONAROMATIC SUBSTRATES AND INHIBITORS Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198310168 |
0.145 |
|
| 1988 |
Guitton MC, Keller BT, Part D, De Gunzburg J, Borchardt RT, Véron M. S-adenosylmethionine, S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase variations during differentiation of Dictyostelium discoideum. Cell Differentiation. 22: 203-10. PMID 2833354 DOI: 10.1016/0045-6039(88)90012-7 |
0.144 |
|
| 1996 |
Tamura K, Lee CP, Smith PL, Borchardt RT. Metabolism, uptake, and transepithelial transport of the stereoisomers of Val-Val-Val in the human intestinal cell line, Caco-2. Pharmaceutical Research. 13: 1663-7. PMID 8956331 DOI: 10.1023/A:1016436606183 |
0.144 |
|
| 1976 |
BORCHARDT RT, HUBER JA, WU YS. ChemInform Abstract: POTENTIAL INHIBITORS OF S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES. 4. URTHER MODIFICATIONS OF THE AMINO ACID AND BASE PORTIONS F S-ADENOSYL-L-HOMOCYSTEINE Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/chin.197652392 |
0.14 |
|
| 2010 |
NICOLAOU MG, WOLFE JL, SCHOWEN RL, BORCHARDT RT. ChemInform Abstract: Facilitated Intramolecular Conjugate Addition of Amides of 3-(3′,6′- Dioxo-2′,4′-dimethyl-1′,4′-cyclohexadienyl)-3,3-dimethylpropionic Acid. Part 2. Kinetics of Degradation. Cheminform. 28: no-no. DOI: 10.1002/chin.199705053 |
0.14 |
|
| 2010 |
LIU S, WNUK SF, YUAN C, ROBINS MJ, BORCHARDT RT. ChemInform Abstract: Adenosine-5′-carboxaldehyde: A Potent Inhibitor of S-Adenosyl-L- homocysteine Hydrolase. Cheminform. 25: no-no. DOI: 10.1002/chin.199410274 |
0.138 |
|
| 2010 |
HILLGREN KM, KATO A, BORCHARDT RT. ChemInform Abstract: In vitro Systems for Studying Intestinal Drug Absorption Cheminform. 26: no-no. DOI: 10.1002/CHIN.199531306 |
0.129 |
|
| 1986 |
SINHABABU AK, BARTEL RL, POCHOPIN N, BORCHARDT RT. ChemInform Abstract: Mechanism of Action of S-Adenosyl-L-homocysteine Hydrolase. Measurement of Kinetic Isotope Effects Using Adenosine-3′-d and S-Adenosyl-L-homocysteine-3′-d as Substrates Chemischer Informationsdienst. 17. DOI: 10.1002/chin.198613091 |
0.127 |
|
| 1982 |
BORCHARDT RT, BHATIA P. ChemInform Abstract: CATECHOL O-METHYLTRANSFERASE. 12. AFFINITY LABELING THE ACTIVE SITE WITH THE OXIDATION PRODUCTS OF 5,6-DIHYDROXYINDOLE Chemischer Informationsdienst. 13. DOI: 10.1002/chin.198233173 |
0.126 |
|
| 1985 |
WU S, HUSKEY WP, BORCHARDT RT, SCHOWEN RL. ChemInform Abstract: DIFFERENT ISOTOPE EFFECTS FOR PARALLEL PATHWAYS OF ENZYME-CATALYZED TRANSMETHYLATION Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198502129 |
0.125 |
|
| 1985 |
HOUSTON DM, DOLENCE EK, KELLER BT, PATEL-THOMBRE U, BORCHARDT RT. ChemInform Abstract: POTENTIAL INHIBITORS OF S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES. 9. ′,3′-DIALDEHYDE DERIVATIVES OF CARBOCYCLIC PURINE NUCLEOSIDES AS INHIBITO S OF S-ADENOSYLHOMOCYSTEINE HYDROLASE Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198531336 |
0.125 |
|
| 2010 |
WOLFE JL, VANDER VELDE D, BORCHARDT RT. ChemInform Abstract: Facilitated Intramolecular Conjugate Addition of N-(p-Methoxyphenyl)-3- (3′,6′-dioxo-2′,4′-dimethylcyclohexa-1′,4′-dienyl)-3,3- dimethylpropionamide. Part 1. Product Characterization. Cheminform. 24: no-no. DOI: 10.1002/chin.199310201 |
0.123 |
|
| 1981 |
VINCEK WC, ALDRICH CS, BORCHARDT RT, GRUNEWALD GL. ChemInform Abstract: IMPORTANCE OF THE AROMATIC RING IN ADRENERGIC AMINES. 5. NONAROMATIC ANALOGS OF PHENYLETHANOLAMINE AS INHIBITORS OF PHENYLETHANOLAMINE N-METHYLTRANSFERASE: ROLE OF HYDROPHOBIC AND STERIC INTERACTIONS Chemischer Informationsdienst. 12. DOI: 10.1002/chin.198123180 |
0.122 |
|
| 1983 |
RAFFERTY MF, KRASS P, BORCHARDT RT, GRUNEWALD GL. ChemInform Abstract: IMPORTANCE OF THE AROMATIC RING IN ADRENERGIC AMINES. 8. 2-(AMINOMETHYL)-TRANS-2-DECALOLS AS INHIBITORS OF NOREPINEPHRINE N-METHYLTRANSFERASE Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198311323 |
0.121 |
|
| 1973 |
BORCHARDT RT. ChemInform Abstract: CATECHOL-O-TRANSFERASE 1. MITT. KINETIK DER TROPOLON-INHIBIERUNG 2. MITT. IN VITRO INHIBIERUNG DURCH SUBSTITUIERTE 8-HYDROXYCHINOLINE 3. MITT. MECHANISMEN DER PYRIDOXAL-5′-PHOSPHAT-INHIBIERUNG Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/chin.197334285 |
0.12 |
|
| 2017 |
Borchardt RT. Journal of Pharmaceutical Sciences. PMID 29133234 DOI: 10.1016/j.xphs.2017.11.004 |
0.12 |
|
| 1979 |
BORCHARDT RT, WU YS, WU BS. ChemInform Abstract: POTENTIAL INHIBITORS OF S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES. PART 7. ROLE OF THE RIBOSYL MOIETY IN ENZYMATIC BINDING OF S-ADENOSYL-L-HOMOCYSTEINE AND S-ADENOSYL-L-METHIONINE Chemischer Informationsdienst. 10. DOI: 10.1002/chin.197918371 |
0.12 |
|
| 1981 |
Vincek WC, Aldrich CS, Borchardt RT, Grunewald GL. Importance of the aromatic ring in adrenergic amines. 5. Nonaromatic analogues of phenylethanolamine as inhibitors of phenylethanolamine N-methyltransferase: role of hydrophobic and steric interactions. Journal of Medicinal Chemistry. 24: 7-12. PMID 7205880 |
0.119 |
|
| 1982 |
BORCHARDT RT, SINHABABU AK. ChemInform Abstract: EFFICIENT SYNTHESIS OF 3,5-DIHYDROXY-4-METHYLBENZOIC ACID Chemischer Informationsdienst. 13. DOI: 10.1002/chin.198216187 |
0.118 |
|
| 1988 |
BORCHERDING DR, SCHOLTZ SA, BORCHARDT RT. ChemInform Abstract: Synthesis of Analogues of Neplanocin A: Utilization of Optically Active Dihydroxycyclopentenones Derived from Carbohydrates. Cheminform. 19. DOI: 10.1002/chin.198817339 |
0.117 |
|
| 1974 |
BORCHARDT RT, HUBER JA, WU YS. ChemInform Abstract: POTENTIAL INHIBITORS OF S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES PART 2, MODIFICATION OF THE BASE PORTION OF S-ADENOSYLHOMOCYSTEINE Chemischer Informationsdienst. 5: no-no. DOI: 10.1002/chin.197447469 |
0.115 |
|
| 1989 |
WOLFE MS, BORCHERDING DR, BORCHARDT RT. ChemInform Abstract: A 9-Step Enantiospecific Synthesis of (-)-Aristeromycin (II) from D-Ribonic Acid γ-Lactone (I). Cheminform. 20. DOI: 10.1002/chin.198939326 |
0.115 |
|
| 1975 |
BORCHARDT RT, HUBER JA. ChemInform Abstract: CATECHOL-O-METHYLTRANSFERASE PART 5, STRUCTURE-ACTIVITY RELATIONSHIPS FOR INHIBITION BY FLAVONOIDS Chemischer Informationsdienst. 6: no-no. DOI: 10.1002/chin.197520276 |
0.114 |
|
| 2010 |
GUAN X, BORCHARDT RT. ChemInform Abstract: A Convenient Method for the Synthesis of Indole-3-acetic Acids. Cheminform. 25: no-no. DOI: 10.1002/chin.199437104 |
0.113 |
|
| 1983 |
SINHABABU AK, BORCHARDT RT. ChemInform Abstract: GENERAL METHOD FOR THE SYNTHESIS OF PHTHALALDEHYDIC ACIDS AND PHTHALIDES FROM O-BROMOBENZALDEHYDES VIA ORTHO-LITHIATED AMINOALKOXIDES Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198347169 |
0.113 |
|
| 1990 |
Borchardt R. Protein transport through cultured brain microvessel endothelial cells, a model of the blood-brain barrier European Journal of Pharmacology. 183: 114. DOI: 10.1016/0014-2999(90)91379-P |
0.112 |
|
| 1990 |
ALI SM, RAMESH K, BORCHARDT RT. ChemInform Abstract: Efficient Enantioselective Syntheses of Carbocyclic Nucleoside and Prostaglandin Synthons. Cheminform. 21. DOI: 10.1002/chin.199049169 |
0.109 |
|
| 1979 |
BORCHARDT RT. ChemInform Abstract: MECHANISM OF ALKALINE HYDROLYSIS OF S-ADENOSYL-L-METHIONINE AND RELATED SULFONIUM NUCLEOSIDES Chemischer Informationsdienst. 10. DOI: 10.1002/chin.197918132 |
0.108 |
|
| 2010 |
KAWASE M, SINHABABU AK, MCGHEE EM, MILBY T, BORCHARDT RT. ChemInform Abstract: Synthesis and Biological Evaluation of 4-Fluoro-, 7-Fluoro-, and 4,7- Difluoro-5,6-dihydroxytryptamines. Cheminform. 22: no-no. DOI: 10.1002/chin.199105200 |
0.108 |
|
| 1989 |
De Clercq E, Cools M, Balzarini J, Marquez VE, Borcherding DR, Borchardt RT, Drach JC, Kitaoka S, Konno T. Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives. Antimicrobial Agents and Chemotherapy. 33: 1291-7. PMID 2552906 DOI: 10.1128/AAC.33.8.1291 |
0.107 |
|
| 1988 |
SINHABABU AK, KAWASE M, BORCHARDT RT. ChemInform Abstract: tert-Butyldimethylsilyl Ethers of Phenols: Their One-Step Conversion to Benzyl or Methyl Ethers and Utility in Regioselective ortho Lithiation. Cheminform. 19. DOI: 10.1002/chin.198808116 |
0.104 |
|
| 1976 |
BORCHARDT RT, HUBER JA, WU YS. ChemInform Abstract: CONVENIENT PREPARATION OF S-ADENOSYLHOMOCYSTEINE AND RELATED COMPOUNDS Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/chin.197619392 |
0.104 |
|
| 2010 |
WOLFE MS, ANDERSON BL, BORCHERDING DR, BORCHARDT RT. ChemInform Abstract: Enantiospecific Syntheses of Aristeromycin and Neplanocin A. Cheminform. 22: no-no. DOI: 10.1002/CHIN.199101346 |
0.104 |
|
| 1983 |
MOORMAN AR, MARTIN T, BORCHARDT RT. ChemInform Abstract: ADDITION OF 1-NITROALKANES TO METHYL 2,3-O-ISOPROPYLIDENE-β-D-RIBO-PENTODIALDO-1,4-FURANOSIDE AND N6-BENZOYL-2′,3′-O-ISOPROPYLIDENEADENOSINE-5′-ALDEHYDE Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198334337 |
0.103 |
|
| 1985 |
HOUSTON DM, DOLENCE EK, KELLER BT, PATEL-THOMBRE U, BORCHARDT RT. ChemInform Abstract: POTENTIAL INHIBITORS OF S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES. 8. OLECULAR DISSECTIONS OF CARBOCYCLIC 3-DEAZAADENOSINE AS INHIBITORS F S-ADENOSYLHOMOCYSTEINE HYDROLASE Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198531233 |
0.102 |
|
| 2002 |
Tang F, Horie K, Borchardt RT. Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharmaceutical Research. 19: 773-9. PMID 12134946 |
0.102 |
|
| 1983 |
RAFFERTY MF, BORCHARDT RT, GRUNEWALD GL. ChemInform Abstract: DIRECTIONAL PROBES OF THE HYDROPHOBIC COMPONENT OF THE AROMATIC RING BINDING SITE OF NOREPINEPHRINE N-METHYLTRANSFERASE Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198310180 |
0.101 |
|
| 1982 |
Grunewald GL, Monn JA, Rafferty MF, Borchardt RT, Krass P. Probes of the active site of norepinephrine N-methyltransferase: Effect of hydrophobic and hydrophilic interactions on side-chain binding of amphetamine and α-methylbenzylamine Journal of Medicinal Chemistry. 25: 1248-1250. |
0.1 |
|
| 1985 |
SINHABABU AK, GHOSH AK, BORCHARDT RT. ChemInform Abstract: MOLECULAR MECHANISM OF ACTION OF 5,6-DIHYDROXYTRYPTAMINE. SYNTHESIS AND BIOLOGICAL EVALUATION OF 4-METHYL-, 7-METHYL- AND 4,7-DIMETHYL-5,6-DIHYDROXYTRYPTAMINES Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198552206 |
0.098 |
|
| 1983 |
SINHABABU AK, BORCHARDT RT. ChemInform Abstract: AN EFFICIENT METHOD FOR THE CONVERSION OF PHENOLIC MANNICH BASES TO C-METHYLATED PHENOLS. SYNTHESIS OF 3,6-DIMETHYLCATECHOL Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198326161 |
0.098 |
|
| 1999 |
Wnuk SF, Yuan C, Borchardt RT, Morris JR. Design and Biological Evaluation of New Mechanismbased Inhibitors ofS-Adenosyl-L-homocysteine Hydrolase Nucleosides and Nucleotides. 18: 595-596. DOI: 10.1080/15257779908041506 |
0.098 |
|
| 1975 |
BORCHARDT RT, THAKKER DR. ChemInform Abstract: CATECHOL O-METHYLTRANSFERASE PART 6, AFFINITY LABELING WITH N-HALOACETYL-3,5-DIMETHOXY-4-HYDROXYPHENYLALKYLAMINES Chemischer Informationsdienst. 6: no-no. DOI: 10.1002/chin.197524226 |
0.093 |
|
| 1980 |
BORCHARDT RT. ChemInform Abstract: S-ADENOSYL-L-METHIONINE-DEPENDENT MACROMOLECULE METHYLTRANSFERASES: POTENTIAL TARGETS FOR THE DESIGN OF CHEMOTHERAPEUTIC AGENTS Chemischer Informationsdienst. 11. DOI: 10.1002/chin.198035352 |
0.093 |
|
| 1983 |
BORCHARDT RT. ChemInform Abstract: Silica Gel-assisted Reduction of Nitrostyrenes to 2-Aryl-1-nitroalkanes with Sodium Borohydride. Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198320120 |
0.091 |
|
| 1996 |
Wang W, Merrill MJ, Borchardt RT. Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro. The American Journal of Physiology. 271: C1973-80. PMID 8997200 DOI: 10.1152/ajpcell.1996.271.6.C1973 |
0.091 |
|
| 1989 |
SINHABABU AK, BORCHARDT RT. ChemInform Abstract: Independent Synthesis of 5-Hydroxytryptamine-4,7-dione (XIX). The Neurocytotoxic Product of Autoxidation of 5,7-Dihydroxytryptamine. Cheminform. 20. DOI: 10.1002/chin.198911318 |
0.09 |
|
| 2010 |
KAWASE M, SINHABABU AK, BORCHARDT RT. ChemInform Abstract: Mechanism of Autoxidation of 5,7-Dihydroxytryptamine: Effect of Fluorine Substitution at Positions 4 and/or 6. Cheminform. 22: no-no. DOI: 10.1002/chin.199123141 |
0.089 |
|
| 1988 |
KAWASE M, SINHABABU AK, BORCHARDT RT. ChemInform Abstract: Silica Gel Assisted Reductive Cyclization of 2-Nitro-β-piperidinostyrenes (III), Derived from 2-Nitrotoluenes (I), to Indoles (IV). Cheminform. 19. DOI: 10.1002/chin.198829156 |
0.087 |
|
| 1989 |
SINHABABU AK, KAWASE M, BORCHARDT RT. ChemInform Abstract: Desilylation of tert-Butyldimethylsilyl Ethers of Phenols. Cheminform. 20. DOI: 10.1002/chin.198903138 |
0.084 |
|
| 1977 |
BORCHARDT RT, REID JR, THAKKER DR, LIANG YO, WIGHTMAN RW, ADAMS RN. ChemInform Abstract: CATECHOL O-METHYLTRANSFERASE. 9. MECHANISM OF INACTIVATION BY 6-HYDROXYDOPAMINE Chemischer Informationsdienst. 8: no-no. DOI: 10.1002/chin.197705184 |
0.081 |
|
| 1983 |
SINHABABU AK, BORCHARDT RT. ChemInform Abstract: SELECTIVE RING C-METHYLATION OF HYDROXYBENZALDEHYDES VIA THEIR MANNICH BASES Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198352112 |
0.079 |
|
| 1968 |
Kupchan SM, Yang TH, King ML, Borchardt RT. Thalictrum alkaloids. 8. The isolation, structural elucidation, and synthesis of dehydrothalicarpine. The Journal of Organic Chemistry. 33: 1052-5. PMID 5639340 DOI: 10.1021/jo01267a022 |
0.078 |
|
| 1974 |
HANNA PE, BORCHARDT RT. ChemInform Abstract: HISTAMINE N-METHYLTRANSFERASE. INHIBITION AND POTENTIATION BY TRANS- AND CIS-1,5-DIPHENYLAMINOPYRROLIDINE Chemischer Informationsdienst. 5: no-no. DOI: 10.1002/chin.197436240 |
0.077 |
|
| 2010 |
ISLAM I, NG K, CHONG KT, MCQUADE TJ, HUI JO, WILKINSON KF, RUSH BD, RUWART MJ, BORCHARDT RT, FISHER JF. ChemInform Abstract: Evaluation of a Vitamin-Cloaking Strategy for Oligopeptide Therapeutics: Biotinylated HIV-1 Protease Inhibitors. Cheminform. 25: no-no. DOI: 10.1002/chin.199420242 |
0.071 |
|
| 2010 |
Ouyang H, Borchardt RT, Siahaan TJ. ChemInform Abstract: Steric Hindrance is a Key Factor in the Coupling Reaction of (Acyloxy) Alkyl-α-halides with Phenols to Make a New Promoiety for Prodrugs. Cheminform. 33: no-no. DOI: 10.1002/chin.200216107 |
0.07 |
|
| 1997 |
Turner MA, Dole K, Yuan CS, Hershfield MS, Borchardt RT, Howell PL. Crystallization and preliminary X-ray analysis of human placental S-adenosylhomocysteine hydrolase Acta Crystallographica Section D: Biological Crystallography. 53: 339-341. DOI: 10.1107/S0907444996014746 |
0.069 |
|
| 1984 |
SINHABABU AK, BORCHARDT RT. ChemInform Abstract: SILICA GEL ASSISTED REDUCTIVE CYCLIZATION OF ALKOXY-2, β-DINITROSTYRENES TO ALKOXYINDOLES Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198407206 |
0.062 |
|
| 1986 |
SINHABABU AK, BORCHARDT RT. ChemInform Abstract: Mechanism and Products of Autoxidation of 5,7-Dihydroxytryptamine. Chemischer Informationsdienst. 17. DOI: 10.1002/chin.198613122 |
0.055 |
|
| 1998 |
Borchardt RT. Ronald T. Borchardt, Ph.D., Recipient of the 1997 AAPS distinguished Pharmaceutical Scientist Award. Pharmaceutical Research. 14: 1500-3. PMID 9434266 DOI: 10.1023/A:1017353629515 |
0.05 |
|
| 2010 |
Borchardt RT. Protein chemistry. Science (New York, N.Y.). 209: 385-6. PMID 17747808 DOI: 10.1126/science.209.4454.385-a |
0.028 |
|
| 2010 |
Borchardt RT. Journal of Pharmaceutical Sciences. Editorial. Journal of Pharmaceutical Sciences. 99: 3279-80. PMID 20552649 DOI: 10.1002/jps.22201 |
0.019 |
|
| 2018 |
Borchardt RT. Editorial Invitation to Become a Reviewer for the Journal of Pharmaceutical Sciences. Journal of Pharmaceutical Sciences. PMID 29425669 DOI: 10.1016/j.xphs.2018.01.028 |
0.019 |
|
| 2020 |
Borchardt RT. Editorial. Journal of Pharmaceutical Sciences. PMID 32623003 DOI: 10.1016/j.xphs.2020.06.024 |
0.01 |
|
| 2020 |
Borchardt RT. Editorial. Journal of Pharmaceutical Sciences. PMID 32007508 DOI: 10.1016/j.xphs.2020.01.018 |
0.01 |
|
| 2019 |
Borchardt RT. Editorial. Journal of Pharmaceutical Sciences. PMID 31884011 DOI: 10.1016/j.xphs.2019.12.018 |
0.01 |
|
| 2019 |
Borchardt RT. Editorial. Journal of Pharmaceutical Sciences. PMID 31870786 DOI: 10.1016/j.xphs.2019.12.013 |
0.01 |
|
| 2019 |
Borchardt RT. Editorial. Journal of Pharmaceutical Sciences. PMID 31730777 DOI: 10.1016/j.xphs.2019.11.003 |
0.01 |
|
| 2019 |
Borchardt RT. Editorial. Journal of Pharmaceutical Sciences. PMID 31676271 DOI: 10.1016/j.xphs.2019.10.044 |
0.01 |
|
| 2019 |
Borchardt RT. Editorial. Journal of Pharmaceutical Sciences. PMID 31128124 DOI: 10.1016/j.xphs.2019.05.014 |
0.01 |
|
| 2019 |
Borchardt RT. Editorial. Journal of Pharmaceutical Sciences. 108: 790. PMID 30576697 DOI: 10.1016/j.xphs.2018.12.007 |
0.01 |
|
| 2019 |
Borchardt RT. Editorial. Journal of Pharmaceutical Sciences. 108: 787. PMID 30576696 DOI: 10.1016/j.xphs.2018.12.008 |
0.01 |
|
| 2019 |
Borchardt RT. Editorial. Journal of Pharmaceutical Sciences. 108: 789. PMID 30528943 DOI: 10.1016/j.xphs.2018.12.001 |
0.01 |
|
| 2019 |
Borchardt RT. Editorial. Journal of Pharmaceutical Sciences. 108: 1. PMID 30471291 DOI: 10.1016/j.xphs.2018.11.020 |
0.01 |
|
| 2019 |
Borchardt RT. Editorial. Journal of Pharmaceutical Sciences. 108: 788. PMID 30445004 DOI: 10.1016/j.xphs.2018.11.011 |
0.01 |
|
| 2018 |
Borchardt RT. Editorial. Journal of Pharmaceutical Sciences. PMID 29665378 DOI: 10.1016/j.xphs.2018.04.004 |
0.01 |
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