Wataru Araki - Publications

Affiliations: 
Natl Inst Neurosci, Japan 

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Komaki K, Takano T, Sato Y, Asada A, Ikeda S, Yamada K, Wei R, Huo A, Fukuchi A, Saito T, Ando K, Murayama S, Araki W, Kametani F, Hasegawa M, et al. Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE1. Journal of Biochemistry. PMID 34523681 DOI: 10.1093/jb/mvab094  0.31
2019 Taniguchi K, Yamamoto F, Arai T, Yang J, Sakai Y, Itoh M, Mamada N, Sekiguchi M, Yamada D, Saitoh A, Kametani F, Tamaoka A, Araki YM, Wada K, Mizusawa H, ... Araki W, et al. Tyrosol Reduces Amyloid-β Oligomer Neurotoxicity and Alleviates Synaptic, Oxidative, and Cognitive Disturbances in Alzheimer's Disease Model Mice. Journal of Alzheimer's Disease : Jad. PMID 31227651 DOI: 10.3233/JAD-190098  0.387
2019 Yamamoto F, Taniguchi K, Mamada N, Tamaoka A, Kametani F, Lakshmana MK, Araki W. TFEB-mediated Enhancement of the Autophagy-lysosomal Pathway Dually Modulates the Process of Amyloid β-Protein Generation in Neurons. Neuroscience. 402: 11-22. PMID 30677488 DOI: 10.1016/j.neuroscience.2019.01.010  0.436
2017 Araki W, Hattori K, Kanemaru K, Yokoi Y, Omachi Y, Takano H, Sakata M, Yoshida S, Tsukamoto T, Murata M, Saito Y, Kunugi H, Goto YI, Nagaoka U, Nagao M, et al. Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders. Biomarker Research. 5: 28. PMID 29018524 DOI: 10.1186/S40364-017-0108-5  0.357
2017 Araki W. Reversibility of Aβ oligomer neurotoxicity. Oncotarget. 8: 50335-50336. PMID 28881565 DOI: 10.18632/oncotarget.19083  0.404
2017 Mamada N, Tanokashira D, Ishii K, Tamaoka A, Araki W. Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein. Biochemical and Biophysical Research Communications. PMID 28302486 DOI: 10.1016/j.bbrc.2017.03.035  0.443
2017 Tanokashira D, Mamada N, Yamamoto F, Taniguchi K, Tamaoka A, Lakshmana MK, Araki W. The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model. Molecular Brain. 10: 4. PMID 28137266 DOI: 10.1186/s13041-016-0284-5  0.424
2016 Araki W. Post-translational regulation of the β-secretase BACE1. Brain Research Bulletin. PMID 27086128 DOI: 10.1016/j.brainresbull.2016.04.009  0.417
2015 Mamada N, Tanokashira D, Hosaka A, Kametani F, Tamaoka A, Araki W. Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons. Molecular Brain. 8: 73. PMID 26552445 DOI: 10.1186/s13041-015-0163-5  0.447
2015 Tanokashira D, Motoki K, Minegishi S, Hosaka A, Mamada N, Tamaoka A, Okada T, Lakshmana MK, Araki W. LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking(1,2,3). Eneuro. 2. PMID 26464978 DOI: 10.1523/ENEURO.0006-15.2015  0.379
2015 Araki W, Tamaoka A. Amyloid beta-protein and lipid rafts: focused on biogenesis and catabolism. Frontiers in Bioscience (Landmark Edition). 20: 314-24. PMID 25553453 DOI: 10.2741/4311  0.43
2014 Araki W, Minegishi S, Motoki K, Kume H, Hohjoh H, Araki YM, Tamaoka A. Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway. Molecular Neurobiology. 50: 1049-58. PMID 24477737 DOI: 10.1007/s12035-014-8644-6  0.376
2014 Ohno M, Hiraoka Y, Lichtenthaler SF, Nishi K, Saijo S, Matsuoka T, Tomimoto H, Araki W, Takahashi R, Kita T, Kimura T, Nishi E. Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model. Neurobiology of Aging. 35: 213-22. PMID 23954170 DOI: 10.1016/j.neurobiolaging.2013.07.014  0.391
2013 Araki W. Potential repurposing of oncology drugs for the treatment of Alzheimer's disease. Bmc Medicine. 11: 82. PMID 23531187 DOI: 10.1186/1741-7015-11-82  0.339
2013 Hosaka A, Araki W, Oda A, Tomidokoro Y, Tamaoka A. Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons. Neurochemical Research. 38: 589-600. PMID 23269484 DOI: 10.1007/s11064-012-0956-1  0.447
2013 Araki W, Oda A, Motoki K, Hattori K, Itoh M, Yuasa S, Konishi Y, Shin RW, Tamaoka A, Ogino K. Reduction of β-amyloid accumulation by reticulon 3 in transgenic mice. Current Alzheimer Research. 10: 135-42. PMID 22742855 DOI: 10.2174/1567205011310020003  0.407
2012 Hayes CD, Dey D, Palavicini JP, Wang H, Araki W, Lakshmana MK. Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice. Plos One. 7: e45841. PMID 23056220 DOI: 10.1371/journal.pone.0045841  0.407
2012 Motoki K, Kume H, Oda A, Tamaoka A, Hosaka A, Kametani F, Araki W. Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant. Brain and Behavior. 2: 270-82. PMID 22741101 DOI: 10.1002/brb3.52  0.443
2012 Mutoh T, Kawamura N, Hirabayashi Y, Shima S, Miyashita T, Ito S, Asakura K, Araki W, Cazzaniga E, Muto E, Masserini M. Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3065-74. PMID 22508690 DOI: 10.1096/fj.11-198630  0.377
2012 Deng J, Hou H, Giunta B, Mori T, Wang YJ, Fernandez F, Weggen S, Araki W, Obregon D, Tan J. Autoreactive-Aβ antibodies promote APP β-secretase processing. Journal of Neurochemistry. 120: 732-40. PMID 22188568 DOI: 10.1111/J.1471-4159.2011.07629.X  0.375
2011 Marutani T, Maeda T, Tanabe C, Zou K, Araki W, Kokame K, Michikawa M, Komano H. ER-stress-inducible Herp, facilitates the degradation of immature nicastrin. Biochimica Et Biophysica Acta. 1810: 790-8. PMID 21600962 DOI: 10.1016/j.bbagen.2011.04.017  0.355
2011 Araki W, Motoki K, Oda A, Kume H, Hohjoh H, Tamaoka A. Disease-associated mutations do not influence the subcellular localization of TDP-43 in neuronal cells Neuroscience Research. 71. DOI: 10.1016/J.Neures.2011.07.831  0.31
2011 Araki W, Oda A, Motoki K, Hattori K, Itoh M, Yuasa S, Konishi Y, Shin R, Tamaoka A, Ogino K. Reduction of beta-amyloid accumulation by reticulon 3 in transgenic mice Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1199  0.366
2010 Araki W, Kametani F, Oda A, Tamaoka A. MEK inhibitors suppress beta-amyloid production by altering the level of a beta-C-terminal fragment of amyloid precursor protein in neuronal cells. Febs Letters. 584: 3410-4. PMID 20600008 DOI: 10.1016/j.febslet.2010.06.038  0.447
2010 Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M. Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. The Journal of Biological Chemistry. 285: 14920-31. PMID 20299451 DOI: 10.1074/Jbc.M109.038760  0.421
2010 Oda A, Tamaoka A, Araki W. Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells. Journal of Neuroscience Research. 88: 1137-45. PMID 19885829 DOI: 10.1002/jnr.22271  0.431
2010 Araki W, Oda A, Motoki K, Hattori K, Itoh M, Yuasa S, Konishi Y, Shin R, Tamaoka A, Ogino K. Suppression of β-amyloid accumulation by reticulon 3 in Alzheimer's disease mouse model Neuroscience Research. 68: e303. DOI: 10.1016/j.neures.2010.07.1345  0.373
2009 Maeda T, Marutani T, Zou K, Araki W, Tanabe C, Yagishita N, Yamano Y, Amano T, Michikawa M, Nakajima T, Komano H. An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein. The Febs Journal. 276: 5832-40. PMID 19725872 DOI: 10.1111/j.1742-4658.2009.07264.x  0.425
2009 Hoshino T, Namba T, Takehara M, Nakaya T, Sugimoto Y, Araki W, Narumiya S, Suzuki T, Mizushima T. Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor. The Journal of Biological Chemistry. 284: 18493-502. PMID 19407341 DOI: 10.1074/Jbc.M109.003269  0.396
2009 Kume H, Murayama KS, Araki W. The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of beta-secretase BACE1. Journal of Neuroscience Research. 87: 2963-72. PMID 19405102 DOI: 10.1002/jnr.22112  0.437
2009 Kume H, Konishi Y, Murayama KS, Kametani F, Araki W. Expression of reticulon 3 in Alzheimer's disease brain. Neuropathology and Applied Neurobiology. 35: 178-88. PMID 19284479 DOI: 10.1111/j.1365-2990.2008.00974.x  0.466
2009 Araki W, Kume H, Oda A, Tamaoka A, Kametani F. IGF-1 promotes beta-amyloid production by a secretase-independent mechanism. Biochemical and Biophysical Research Communications. 380: 111-4. PMID 19167357 DOI: 10.1016/j.bbrc.2009.01.044  0.453
2008 Araki W, Takahashi-Sasaki N, Chui DH, Saito S, Takeda K, Shirotani K, Takahashi K, Murayama KS, Kametani F, Shiraishi H, Komano H, Tabira T. A family of membrane proteins associated with presenilin expression and gamma-secretase function. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 819-27. PMID 17928364 DOI: 10.1096/fj.07-9072com  0.463
2008 Hoshino T, Nakaya T, Sugimoto Y, Araki W, Narumiya S, Suzuki T, Mizushima T. O4-06-07: Involvement of the prostaglandin E2 receptors, EP2 and EP4 , in the production of amyloid-β peptides both in vitro and in vivo Alzheimer's & Dementia. 4: T198-T198. DOI: 10.1016/J.Jalz.2008.05.551  0.311
2007 Hoshino T, Nakaya T, Homan T, Tanaka K, Sugimoto Y, Araki W, Narita M, Narumiya S, Suzuki T, Mizushima T. Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo. The Journal of Biological Chemistry. 282: 32676-88. PMID 17767011 DOI: 10.1074/Jbc.M703087200  0.459
2007 Murayama KS, Kametani F, Tabira T, Araki W. A novel monoclonal antibody specific for the amino-truncated beta-amyloid Abeta5-40/42 produced from caspase-cleaved amyloid precursor protein. Journal of Neuroscience Methods. 161: 244-9. PMID 17207535 DOI: 10.1016/j.jneumeth.2006.11.010  0.447
2007 Hoshino T, Nakaya T, Araki W, Suzuki K, Suzuki T, Mizushima T. Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides. The Biochemical Journal. 402: 581-9. PMID 17132139 DOI: 10.1042/Bj20061318  0.405
2006 Murayama KS, Kametani F, Saito S, Kume H, Akiyama H, Araki W. Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein. The European Journal of Neuroscience. 24: 1237-44. PMID 16965550 DOI: 10.1111/j.1460-9568.2006.05005.x  0.492
2006 Araki W, Saito S, Takahashi-Sasaki N, Shiraishi H, Komano H, Murayama KS. Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif. Journal of Molecular Neuroscience : Mn. 29: 35-43. PMID 16757808 DOI: 10.1385/JMN:29:1:35  0.326
2006 Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, et al. Altered localization of amyloid precursor protein under endoplasmic reticulum stress. Biochemical and Biophysical Research Communications. 344: 525-30. PMID 16630560 DOI: 10.1016/j.bbrc.2006.03.173  0.432
2006 Shiraishi H, Marutani T, Wang HQ, Maeda Y, Kurono Y, Takashima A, Araki W, Nishimura M, Yanagisawa K, Komano H. Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 11: 83-93. PMID 16371134 DOI: 10.1111/j.1365-2443.2005.00914.x  0.33
2005 Murayama KS, Kametani F, Araki W. Extracellular release of BACE1 holoproteins from human neuronal cells. Biochemical and Biophysical Research Communications. 338: 800-7. PMID 16243299 DOI: 10.1016/j.bbrc.2005.10.015  0.393
2005 Hamano T, Mutoh T, Tabira T, Araki W, Kuriyama M, Mihara T, Yano S, Yamamoto H. Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein. Brain Research. Molecular Brain Research. 137: 70-6. PMID 15950763 DOI: 10.1016/j.molbrainres.2005.02.018  0.43
2005 Lakshmana MK, Araki W, Tabira T. Amyloid beta peptide binds a novel death-inducing protein, AB-DIP. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1362-4. PMID 15923395 DOI: 10.1096/fj.05-3672fje  0.477
2005 Hasegawa T, Ukai W, Jo DG, Xu X, Mattson MP, Nakagawa M, Araki W, Saito T, Yamada T. Homocysteic acid induces intraneuronal accumulation of neurotoxic Abeta42: implications for the pathogenesis of Alzheimer's disease. Journal of Neuroscience Research. 80: 869-76. PMID 15898106 DOI: 10.1002/Jnr.20514  0.464
2005 Saito S, Takahashi-Sasaki N, Araki W. Identification and characterization of a novel human APH-1b splice variant lacking exon 4. Biochemical and Biophysical Research Communications. 330: 1068-72. PMID 15823552 DOI: 10.1016/j.bbrc.2005.03.096  0.334
2004 Takeda K, Araki W, Akiyama H, Tabira T. Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1755-7. PMID 15364896 DOI: 10.1096/fj.03-1070fje  0.499
2004 Watanabe N, Araki W, Chui DH, Makifuchi T, Ihara Y, Tabira T. Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1013-5. PMID 15084524 DOI: 10.1096/fj.03-1040fje  0.483
2004 Takeda K, Araki W, Tabira T. Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2. The European Journal of Neuroscience. 19: 258-264. PMID 14725619 DOI: 10.1111/j.0953-816X.2003.03135.x  0.475
2004 Murayama K, Kametani F, Takahashi N, Saito S, Araki W. P4-196 Analysis of the secretion mechanism of beta-secretases Neurobiology of Aging. 25: S531. DOI: 10.1016/S0197-4580(04)81754-8  0.308
2001 Chui DH, Dobo E, Makifuchi T, Akiyama H, Kawakatsu S, Petit A, Checler F, Araki W, Takahashi K, Tabira T. Apoptotic neurons in Alzheimer's disease frequently show intracellular Abeta42 labeling. Journal of Alzheimer's Disease : Jad. 3: 231-239. PMID 12214064 DOI: 10.3233/Jad-2001-3208  0.471
2001 Araki W, Yuasa K, Takeda S, Takeda K, Shirotani K, Takahashi K, Tabira T. Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons. Journal of Neurochemistry. 79: 1161-8. PMID 11752057 DOI: 10.1046/j.1471-4159.2001.00638.x  0.447
2001 Miyamoto K, Kowalska A, Hasegawa M, Tabira T, Takahashi K, Araki W, Akiguchi I, Ikemoto A. Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10+11-splice site in the tau gene. Annals of Neurology. 50: 117-20. PMID 11456301 DOI: 10.1002/Ana.1083  0.301
2000 Araki W, Yuasa K, Takeda S, Shirotani K, Takahashi K, Tabira T. Overexpression of presenilin-2 enhances apoptotic death of cultured cortical neurons. Annals of the New York Academy of Sciences. 920: 241-4. PMID 11193157 DOI: 10.1111/J.1749-6632.2000.Tb06929.X  0.345
2000 Shirotani K, Takahashi K, Araki W, Maruyama K, Tabira T. Mutational analysis of intrinsic regions of presenilin 2 that determine its endoproteolytic cleavage and pathological function. The Journal of Biological Chemistry. 275: 3681-6. PMID 10652366 DOI: 10.1074/jbc.275.5.3681  0.396
1999 Chui DH, Tanahashi H, Ozawa K, Ikeda S, Checler F, Ueda O, Suzuki H, Araki W, Inoue H, Shirotani K, Takahashi K, Gallyas F, Tabira T. Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nature Medicine. 5: 560-4. PMID 10229234 DOI: 10.1038/8438  0.411
1998 Araki W, Wurtman RJ. Increased expression of amyloid precursor protein and amyloid precursor-like protein 2 during trophic factor withdrawal-induced death of neuronal PC12 cells. Brain Research. Molecular Brain Research. 56: 169-77. PMID 9602112 DOI: 10.1016/S0169-328X(98)00050-3  0.558
1998 Araki W, Wurtman RJ. How is membrane phospholipid biosynthesis controlled in neural tissues? Journal of Neuroscience Research. 51: 667-74. PMID 9545081 DOI: 10.1002/(SICI)1097-4547(19980315)51:6<667::AID-JNR1>3.0.CO;2-9  0.423
1997 Araki W, Wurtman RJ. Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 94: 11946-50. PMID 9342342 DOI: 10.1073/pnas.94.22.11946  0.47
1997 Lee RK, Araki W, Wurtman RJ. Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation. Proceedings of the National Academy of Sciences of the United States of America. 94: 5422-6. PMID 9144253 DOI: 10.1073/pnas.94.10.5422  0.59
1996 Lees RK, Araki W, Wurtman RJ. 808 Regulation of amyloid precursor protein processing and synthesis by receptor-mediated signal transduction Neurobiology of Aging. 17: S201. DOI: 10.1016/S0197-4580(96)80810-4  0.484
1995 Araki W, Kunishita T, Takahashi K, Ikeda S, Tabira T. Secretion kinetics of Alzheimer's amyloid beta-protein differs from secreted beta-amyloid precursor protein. Biochemical and Biophysical Research Communications. 214: 490-5. PMID 7677756 DOI: 10.1006/bbrc.1995.2313  0.407
1994 Araki W, Kunishita T, Takahashi K, Ikeda S, Tabira T. Demonstration of amyloid beta-protein secretion in a mouse neuronal cell line. Neuroscience Letters. 167: 125-7. PMID 8177510 DOI: 10.1016/0304-3940(94)91043-X  0.411
1994 Kunishita T, Ikeda S, Araki W, Tabira T. The decrement of muscarinic receptor-mediated calcium influx by overexpression of APP in a mouse cholinergic cell line. The Tohoku Journal of Experimental Medicine. 174: 225-39. PMID 7761988 DOI: 10.1620/Tjem.174.225  0.403
1991 Araki W, Kitaguchi N, Tokushima Y, Ishii K, Aratake H, Shimohama S, Nakamura S, Kimura J. Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture. Biochemical and Biophysical Research Communications. 181: 265-71. PMID 1958195 DOI: 10.1016/S0006-291X(05)81412-3  0.451
1991 Shimohama S, Suenaga T, Araki W, Yamaoaka Y, Shimizu K, Kimura J. Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease. Brain Research. 558: 105-8. PMID 1718565 DOI: 10.1016/0006-8993(91)90722-8  0.358
1990 Nakamura S, Kawashima S, Nakano S, Tsuji T, Araki W. Subcellular distribution of acetylcholinesterase in Alzheimer's disease: abnormal localization and solubilization. Journal of Neural Transmission. Supplementum. 30: 13-23. PMID 2391513 DOI: 10.1007/978-3-7091-3345-3_2  0.336
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