☰

Stanley L. Hazen - Publications

Affiliations: 
Cellular and Molecular Medicine Cleveland Clinic Lerner Research Institute 
Area:
Analytical Chemistry
Website:
https://newsroom.clevelandclinic.org/2017/11/12/cleveland-clinics-stanley-hazen-m-d-ph-d-recognized-as-2017-distinguished-scientist-by-the-american-heart-association/
Tree Info Similar researchers PubMed Report error

261 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Dwidar M, Buffa JA, Wang Z, Santos A, Tittle AN, Fu X, Hajjar AM, DiDonato JA, Hazen SL. Assembling the anaerobic gamma-butyrobetaine to TMA metabolic pathway in and confirming its role in TMA production from dietary carnitine in murine models. Mbio. e0093723. PMID 37737636 DOI: 10.1128/mbio.00937-23  0.579
2023 Wang M, Li XS, Wang Z, de Oliveira Otto MC, Lemaitre RN, Fretts A, Sotoodehnia N, Budoff M, Nemet I, DiDonato JA, Tang WHW, Psaty BM, Siscovick DS, Hazen SL, Mozaffarian D. Trimethylamine N-oxide is associated with long-term mortality risk: the multi-ethnic study of atherosclerosis. European Heart Journal. PMID 36883587 DOI: 10.1093/eurheartj/ehad089  0.555
2023 Witkowski M, Nemet I, Alamri H, Wilcox J, Gupta N, Nimer N, Haghikia A, Li XS, Wu Y, Saha PP, Demuth I, König M, Steinhagen-Thiessen E, Cajka T, Fiehn O, ... ... Hazen SL, et al. The artificial sweetener erythritol and cardiovascular event risk. Nature Medicine. PMID 36849732 DOI: 10.1038/s41591-023-02223-9  0.653
2022 Zhu Y, Dwidar M, Nemet I, Buffa JA, Sangwan N, Li XS, Anderson JT, Romano KA, Fu X, Funabashi M, Wang Z, Keranahalli P, Battle S, Tittle AN, Hajjar AM, ... ... Hazen SL, et al. Two distinct gut microbial pathways contribute to meta-organismal production of phenylacetylglutamine with links to cardiovascular disease. Cell Host & Microbe. PMID 36549300 DOI: 10.1016/j.chom.2022.11.015  0.742
2022 Romano KA, Nemet I, Prasad Saha P, Haghikia A, Li XS, Mohan ML, Lovano B, Castel L, Witkowski M, Buffa JA, Sun Y, Li L, Menge CM, Demuth I, König M, ... ... Hazen SL, et al. Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure. Circulation. Heart Failure. e009972. PMID 36524472 DOI: 10.1161/CIRCHEARTFAILURE.122.009972  0.55
2022 Wang M, Wang Z, Lee Y, Lai HTM, de Oliveira Otto MC, Lemaitre RN, Fretts A, Sotoodehnia N, Budoff M, DiDonato JA, McKnight B, Tang WHW, Psaty BM, Siscovick DS, Hazen SL, et al. Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA121316533. PMID 35912635 DOI: 10.1161/ATVBAHA.121.316533  0.583
2022 Malaeb H, Choucair I, Wang Z, Li XS, Li L, Boyd WC, Hine C, Tang WHW, Gogonea V, Hazen SL. Stable isotope dilution mass spectrometry quantification of hydrogen sulfide and thiols in biological matrices. Redox Biology. 55: 102401. PMID 35870340 DOI: 10.1016/j.redox.2022.102401  0.59
2022 Fretts AM, Hazen SL, Jensen P, Budoff M, Sitlani CM, Wang M, de Oliveira Otto MC, DiDonato JA, Lee Y, Psaty BM, Siscovick DS, Sotoodehnia N, Tang WHW, Lai H, Lemaitre RN, et al. Association of Trimethylamine N-Oxide and Metabolites With Mortality in Older Adults. Jama Network Open. 5: e2213242. PMID 35594043 DOI: 10.1001/jamanetworkopen.2022.13242  0.553
2022 Battle S, Gogonea V, Willard B, Wang Z, Fu X, Huang Y, Graham LM, Cameron SJ, DiDonato JA, Crabb JW, Hazen SL. The pattern of apolipoprotein A-I lysine carbamylation reflects its lipidation state and the chemical environment within human atherosclerotic aorta. The Journal of Biological Chemistry. 101832. PMID 35304099 DOI: 10.1016/j.jbc.2022.101832  0.766
2021 Buffa JA, Romano KA, Copeland MF, Cody DB, Zhu W, Galvez R, Fu X, Ward K, Ferrell M, Dai HJ, Skye S, Hu P, Li L, Parlov M, McMillan A, ... ... Hazen SL, et al. The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota L-carnitine catabolism. Nature Microbiology. PMID 34949826 DOI: 10.1038/s41564-021-01010-x  0.732
2021 Wang Z, Hazen J, Jia X, Org E, Zhao Y, Osborn LJ, Nimer N, Buffa J, Culley MK, Krajcik D, van den Born BH, Zwinderman K, Levison BS, Nieuwdorp M, Lusis AJ, ... ... Hazen SL, et al. The Nutritional Supplement -Alpha Glycerylphosphorylcholine Promotes Atherosclerosis. International Journal of Molecular Sciences. 22. PMID 34948275 DOI: 10.3390/ijms222413477  0.595
2021 Lee Y, Nemet I, Wang Z, Lai HTM, de Oliveira Otto MC, Lemaitre RN, Fretts AM, Sotoodehnia N, Budoff M, DiDonato JA, McKnight B, Tang WHW, Psaty BM, Siscovick DS, Hazen SL, et al. Longitudinal Plasma Measures of Trimethylamine N-Oxide and Risk of Atherosclerotic Cardiovascular Disease Events in Community-Based Older Adults. Journal of the American Heart Association. e020646. PMID 34398665 DOI: 10.1161/JAHA.120.020646  0.56
2021 Witkowski M, Witkowski M, Friebel J, Buffa JA, Li XS, Wang Z, Sangwan N, Li L, DiDonato JA, Tizian C, Haghikia A, Kirchhofer D, Mach F, Räber L, Matter CM, ... ... Hazen SL, et al. Vascular endothelial Tissue Factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis. Cardiovascular Research. PMID 34352109 DOI: 10.1093/cvr/cvab263  0.558
2021 Zhu W, Romano KA, Li L, Buffa JA, Sangwan N, Prakash P, Tittle AN, Li XS, Fu X, Androjna C, DiDonato AJ, Brinson K, Trapp BD, Fischbach MA, Rey FE, ... ... Hazen SL, et al. Gut microbes impact stroke severity via the trimethylamine N-oxide pathway. Cell Host & Microbe. PMID 34139173 DOI: 10.1016/j.chom.2021.05.002  0.543
2021 Mohan ML, Nagatomo Y, Saha PP, Mukherjee SD, Engelman T, Morales R, Hazen SL, Tang WHW, Prasad SVN. The IgG3 Subclass of β1-adrenergic receptor autoantibody is an endogenous biaser of β1AR signaling. Molecular Biology of the Cell. mbcE20060394. PMID 33534612 DOI: 10.1091/mbc.E20-06-0394  0.631
2020 Jang HS, Gu X, Cooley RB, Porter JJ, Henson RL, Willi T, DiDonato JA, Hazen SL, Mehl RA. Correction to Efficient Site-Specific Prokaryotic and Eukaryotic Incorporation of Halotyrosine Amino Acids into Proteins. Acs Chemical Biology. PMID 33382237 DOI: 10.1021/acschembio.0c00951  0.525
2020 Nimer N, Choucair I, Wang Z, Nemet I, Li L, Gukasyan J, Weeks TL, Alkhouri N, Zein N, Tang WHW, Fischbach MA, Brown JM, Allayee H, Dasarathy S, Gogonea V, ... Hazen SL, et al. Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression. Metabolism: Clinical and Experimental. 154457. PMID 33275980 DOI: 10.1016/j.metabol.2020.154457  0.586
2020 Witkowski M, Weeks TL, Hazen SL. Gut Microbiota and Cardiovascular Disease. Circulation Research. 127: 553-570. PMID 32762536 DOI: 10.1161/Circresaha.120.316242  0.361
2020 Zamanian-Daryoush M, Lindner DJ, Buffa J, Gopalan B, Na J, Hazen SL, DiDonato JA. Apolipoprotein A-I anti-tumor activity targets cancer cell metabolism. Oncotarget. 11: 1777-1796. PMID 32477466 DOI: 10.18632/Oncotarget.27590  0.58
2020 Organ CL, Li Z, Sharp TE, Polhemus DJ, Gupta N, Goodchild TT, Tang WHW, Hazen SL, Lefer DJ. Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure. Journal of the American Heart Association. e016223. PMID 32390485 DOI: 10.1161/Jaha.119.016223  0.33
2020 Gencer B, Li XS, Gurmu Y, Bonaca MP, Morrow DA, Cohen M, Bhatt DL, Steg PG, Storey RF, Johanson P, Wang Z, Hazen SL, Sabatine MS. Gut Microbiota-Dependent Trimethylamine N-oxide and Cardiovascular Outcomes in Patients With Prior Myocardial Infarction: A Nested Case Control Study From the PEGASUS-TIMI 54 Trial. Journal of the American Heart Association. e015331. PMID 32366163 DOI: 10.1161/Jaha.119.015331  0.31
2020 Pathak P, Helsley RN, Brown AL, Buffa JA, Choucair I, Nemet I, Baleanu Gogonea C, Gogonea V, Wang Z, Garcia-Garcia JC, Cai L, Temel RE, Sangwan N, Hazen SL, Brown JM. Small Molecule Inhibition of Gut Microbial Choline Trimethylamine Lyase Activity Alters Host Cholesterol and Bile Acid Metabolism. American Journal of Physiology. Heart and Circulatory Physiology. PMID 32330092 DOI: 10.1152/Ajpheart.00584.2019  0.68
2020 Gupta N, Buffa JA, Roberts AB, Sangwan N, Skye SM, Li L, Ho KJ, Varga J, DiDonato JA, Tang WHW, Hazen SL. Targeted Inhibition of Gut Microbial TMAO Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120314139. PMID 32212854 DOI: 10.1161/Atvbaha.120.314139  0.599
2020 Nemet I, Saha PP, Gupta N, Zhu W, Romano KA, Skye SM, Cajka T, Mohan ML, Li L, Wu Y, Funabashi M, Ramer-Tait AE, Naga Prasad SV, Fiehn O, Rey FE, ... ... Hazen SL, et al. A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. Cell. 180: 862-877.e22. PMID 32142679 DOI: 10.1016/J.Cell.2020.02.016  0.764
2020 Zamanian-Daryoush M, Gogonea V, DiDonato AJ, Buffa JA, Choucair I, Levison BS, Hughes RA, Ellington AD, Huang Y, Li XS, DiDonato JA, Hazen SL. Site-specific 5-hydroxy-tryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high density lipoprotein biogenesis. The Journal of Biological Chemistry. PMID 32098873 DOI: 10.1074/Jbc.Ra119.012092  0.772
2020 Jang HS, Gu X, Cooley RB, Porter JJ, Henson RL, Willi T, DiDonato JA, Hazen SL, Mehl RA. Efficient site-specific prokaryotic and eukaryotic incorporation of halotyrosine amino acids into proteins. Acs Chemical Biology. PMID 31994864 DOI: 10.1021/Acschembio.9B01026  0.635
2020 Brubaker G, Lorkowski SW, Gulshan K, Hazen SL, Gogonea V, Smith JD. First eight residues of apolipoprotein A-I mediate the C-terminus control of helical bundle unfolding and its lipidation. Plos One. 15: e0221915. PMID 31945064 DOI: 10.1371/Journal.Pone.0221915  0.636
2020 Gogonea V, Peters J, Gerstenecker GS, Topbas C, Hou L, Combet J, DiDonato JA, Smith JD, Rye KA, Hazen SL. Protein Backbone and Average Particle Dynamics in Reconstituted Discoidal and Spherical HDL Probed by Hydrogen Deuterium Exchange and Elastic Incoherent Neutron Scattering. Biomolecules. 10. PMID 31936876 DOI: 10.3390/biom10010121  0.791
2019 Choucair I, Nemet I, Li L, Cole MA, Skye SM, Kirsop JD, Fischbach M, Gogonea V, Brown JM, Tang WHW, Hazen SL. Quantification of bile acids: A mass spectrometry platform for studying gut microbe connection to metabolic diseases. Journal of Lipid Research. PMID 31818878 DOI: 10.1194/Jlr.Ra119000311  0.662
2019 Garcia E, Osté MCJ, Bennett DW, Jeyarajah EJ, Shalaurova I, Gruppen EG, Hazen SL, Otvos JD, Bakker SJL, Dullaart RPF, Connelly MA. High Betaine, a Trimethylamine N-Oxide Related Metabolite, Is Prospectively Associated with Low Future Risk of Type 2 Diabetes Mellitus in the PREVEND Study. Journal of Clinical Medicine. 8. PMID 31683780 DOI: 10.3390/Jcm8111813  0.315
2019 Vuilleumier N, Pagano S, Combescure C, Gencer B, Virzi J, Räber L, Carballo D, Carballo S, Nanchen D, Rodondi N, Windecker S, Hazen SL, Wang Z, Li XS, von Eckardstein A, et al. Non-Linear Relationship between Anti-Apolipoprotein A-1 IgGs and Cardiovascular Outcomes in Patients with Acute Coronary Syndromes. Journal of Clinical Medicine. 8. PMID 31324073 DOI: 10.3390/Jcm8071002  0.303
2019 Shih DM, Zhu W, Schugar RC, Meng Y, Jia X, Miikeda A, Wang Z, Zieger M, Lee R, Graham M, Allayee H, Cantor RM, Mueller C, Brown JM, Hazen SL, et al. Genetic Deficiency of Flavin-Containing Monooxygenase-3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119312592. PMID 31070450 DOI: 10.1161/Atvbaha.119.312592  0.335
2019 Li XS, Obeid S, Wang Z, Hazen BJ, Li L, Wu Y, Hurd AG, Gu X, Pratt A, Levison BS, Chung YM, Nissen SE, Tang WHW, Mach F, Räber L, ... ... Hazen SL, et al. Trimethyllysine, a trimethylamine N-oxide precursor, provides near- and long-term prognostic value in patients presenting with acute coronary syndromes. European Heart Journal. PMID 31049589 DOI: 10.1093/Eurheartj/Ehz259  0.323
2019 Tang WHW, Bäckhed F, Landmesser U, Hazen SL. Intestinal Microbiota in Cardiovascular Health and Disease: JACC State-of-the-Art Review. Journal of the American College of Cardiology. 73: 2089-2105. PMID 31023434 DOI: 10.1016/J.Jacc.2019.03.024  0.336
2019 Barkan-Talmor Y, Ayers C, Hong W, Tang W, Witberg G, Eisen A, Hamdan A, Hazen SL, Lemos JAd, Kornowski R, Neeland I. Trimethylamine-N-Oxide And Related Metabolites Are Associated With Cardiovascular Events: Results From The Dallas Heart Study Journal of the American College of Cardiology. 73: 1739. DOI: 10.1016/S0735-1097(19)32345-9  0.375
2019 Koeth R, Culley M, Wang Z, Nemet I, Kirsop J, Org E, Buffa J, Li X, Levison B, Bartlett D, Fu X, Wu Y, Li L, Smith J, DiDonato J, ... ... Hazen SL, et al. CROTONOBETAINE IS A PROATHEROGENIC GUT MICROBIOTA METABOLITE OF L-CARNITINE Journal of the American College of Cardiology. 73: 14. DOI: 10.1016/S0735-1097(19)30623-0  0.592
2018 Wang Z, Bergeron N, Levison BS, Li XS, Chiu S, Jia X, Koeth RA, Li L, Wu Y, Tang WHW, Krauss RM, Hazen SL. Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women. European Heart Journal. PMID 30535398 DOI: 10.1093/Eurheartj/Ehy799  0.307
2018 Koeth RA, Lam-Galvez BR, Kirsop J, Wang Z, Levison BS, Gu X, Copeland MF, Bartlett D, Cody DB, Dai HJ, Culley MK, Li XS, Fu X, Wu Y, Li L, ... ... Hazen SL, et al. l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans. The Journal of Clinical Investigation. PMID 30530985 DOI: 10.1172/Jci94601  0.609
2018 Tang WHW, Li DY, Hazen SL. Dietary metabolism, the gut microbiome, and heart failure. Nature Reviews. Cardiology. PMID 30410105 DOI: 10.1038/S41569-018-0108-7  0.34
2018 Skye SM, Zhu W, Romano KA, Guo CJ, Wang Z, Jia X, Kirsop J, Haag B, Lang JM, DiDonato JA, Tang WHW, Lusis AJ, Rey FE, Fischbach MA, Hazen SL. Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential. Circulation Research. 123: 1164-1176. PMID 30359185 DOI: 10.1161/Circresaha.118.313142  0.619
2018 Roberts AB, Gu X, Buffa JA, Hurd AG, Wang Z, Zhu W, Gupta N, Skye SM, Cody DB, Levison BS, Barrington WT, Russell MW, Reed JM, Duzan A, Lang JM, ... ... Hazen SL, et al. Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential. Nature Medicine. PMID 30082863 DOI: 10.1038/S41591-018-0128-1  0.754
2018 Zhu W, Buffa JA, Wang Z, Warrier M, Schugar R, Shih DM, Gupta N, Gregory JC, Org E, Fu X, Li L, DiDonato JA, Lusis AJ, Brown JM, Hazen SL. Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk. Journal of Thrombosis and Haemostasis : Jth. PMID 29981269 DOI: 10.1111/jth.14234  0.574
2018 Haghikia A, Li XS, Liman TG, Bledau N, Schmidt D, Zimmermann F, Kränkel N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Fraccarollo D, Heimesaat MM, Bauersachs J, Wang Z, ... ... Hazen SL, et al. Gut Microbiota-Dependent Trimethylamine -Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 29976769 DOI: 10.1161/Atvbaha.118.311023  0.302
2018 Halawani D, Gogonea V, DiDonato JA, Pipich V, Yao P, China A, Topbas C, Vasu K, Arif A, Hazen SL, Fox PL. Structural control of caspase-generated glutamyl-tRNA synthetase by appended noncatalytic WHEP domains. The Journal of Biological Chemistry. PMID 29643180 DOI: 10.1074/Jbc.M117.807503  0.762
2018 Smits LP, Kootte RS, Levin E, Prodan A, Fuentes S, Zoetendal EG, Wang Z, Levison BS, Cleophas MCP, Kemper EM, Dallinga-Thie GM, Groen AK, Joosten LAB, Netea MG, Stroes ESG, ... ... Hazen SL, et al. Effect of Vegan Fecal Microbiota Transplantation on Carnitine- and Choline-Derived Trimethylamine-N-Oxide Production and Vascular Inflammation in Patients With Metabolic Syndrome. Journal of the American Heart Association. 7. PMID 29581220 DOI: 10.1161/Jaha.117.008342  0.362
2018 Li XS, Wang Z, Cajka T, Buffa JA, Nemet I, Hurd AG, Gu X, Skye SM, Roberts AB, Wu Y, Li L, Shahen CJ, Wagner MA, Hartiala JA, Kerby RL, ... ... Hazen SL, et al. Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk. Jci Insight. 3. PMID 29563342 DOI: 10.1172/Jci.Insight.99096  0.62
2018 Tang WHW, McGee P, Lachin JM, Li DY, Hoogwerf B, Hazen SL, Dcct. Oxidative stress and cardiovascular risk in type 1 diabetes mellitus: Insights from the DCCT/EDIC study Journal of the American Heart Association. 7. DOI: 10.1161/Jaha.117.008368  0.302
2018 Roberts A, Gu X, Buffa JA, Zhu W, Hazen SL. Abstract 430: Development of a Gut-microbe Targeted Non-lethal Therapeutic to Inhibit Thrombosis Potential Without Enhanced Bleeding Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.430  0.335
2018 Li DY, Wang Z, Li XS, Hazen SL, Tang WHW. Relationship Between Statin Use And Trimethylamine N-Oxide In Cardiovascular Risk Assessment Journal of the American College of Cardiology. 71. DOI: 10.1016/S0735-1097(18)30656-9  0.351
2017 Zamanian-Daryoush M, Lindner DJ, DiDonato JA, Wagner M, Buffa J, Rayman P, Parks JS, Westerterp M, Tall AR, Hazen SL. Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer. Oncotarget. 8: 71965-71980. PMID 29069761 DOI: 10.18632/Oncotarget.18666  0.599
2017 Kim HW, Blomkalns AL, Ogbi M, Thomas M, Gavrila D, Neltner BS, Cassis LA, Thompson RW, Weiss RM, Lindower PD, Blanco VM, McCormick ML, Daugherty A, Fu X, Hazen SL, et al. Role of myeloperoxidase in abdominal aortic aneurysm formation: mitigation by taurine. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00296.2017. PMID 28971841 DOI: 10.1152/Ajpheart.00296.2017  0.313
2017 Zamanian-Daryoush M, Lindner DJ, DiDonato JA, Wagner M, Buffa J, Rayman P, Parks JS, Westerterp M, Tall AR, Hazen SL. Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer. Oncotarget. PMID 28666268 DOI: 10.18632/oncotarget.18666  0.558
2017 Garcia E, Wolak-Dinsmore J, Wang Z, Li XS, Bennett DW, Connelly MA, Otvos JD, Hazen SL, Jeyarajah EJ. NMR quantification of trimethylamine-N-oxide in human serum and plasma in the clinical laboratory setting. Clinical Biochemistry. PMID 28624482 DOI: 10.1016/J.Clinbiochem.2017.06.003  0.344
2017 Zewinger S, Kleber ME, Tragante V, McCubrey RO, Schmidt AF, Direk K, Laufs U, Werner C, Koenig W, Rothenbacher D, Mons U, Breitling LP, Brenner H, Jennings RT, Petrakis I, ... ... Hazen SL, et al. Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study. The Lancet. Diabetes & Endocrinology. PMID 28566218 DOI: 10.1016/S2213-8587(17)30096-7  0.313
2017 Zhu W, Wang Z, Tang WHW, Hazen SL. Gut Microbe-Generated Trimethylamine N-Oxide From Dietary Choline Is Prothrombotic in Subjects. Circulation. 135: 1671-1673. PMID 28438808 DOI: 10.1161/Circulationaha.116.025338  0.347
2017 Brown JM, Hazen SL. Targeting of Microbe-Derived Metabolites to Improve Human Health: The Next Frontier for Drug Discovery. The Journal of Biological Chemistry. PMID 28389555 DOI: 10.1074/Jbc.R116.765388  0.314
2017 Tang WH, Kitai T, Hazen SL. Gut Microbiota in Cardiovascular Health and Disease. Circulation Research. 120: 1183-1196. PMID 28360349 DOI: 10.1161/Circresaha.117.309715  0.342
2017 Tang WH, Hazen SL. The Gut Microbiome and Its Role in Cardiovascular Diseases. Circulation. 135: 1008-1010. PMID 28289004 DOI: 10.1161/Circulationaha.116.024251  0.307
2017 Hammadah M, Kalogeropoulos AP, Georgiopoulou VV, Weber M, Wu Y, Hazen SL, Butler J, Tang WH. High-density lipoprotein-associated paraoxonase-1 activity for prediction of adverse outcomes in outpatients with chronic heart failure. European Journal of Heart Failure. PMID 28176482 DOI: 10.1002/Ejhf.777  0.316
2017 Tang WH, Hazen SL. Atherosclerosis in 2016: Advances in new therapeutic targets for atherosclerosis. Nature Reviews. Cardiology. 14: 71-72. PMID 28094270 DOI: 10.1038/Nrcardio.2016.216  0.313
2017 Li XS, Obeid S, Klingenberg R, Gencer B, Mach F, Räber L, Windecker S, Rodondi N, Nanchen D, Muller O, Miranda MX, Matter CM, Wu Y, Li L, Wang Z, ... ... Hazen SL, et al. Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors. European Heart Journal. PMID 28077467 DOI: 10.1093/Eurheartj/Ehw582  0.667
2017 Lin H, Levison BS, Buffa JA, Huang Y, Fu X, Wang Z, Gogonea V, DiDonato JA, Hazen SL. Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo. Free Radical Biology & Medicine. PMID 28069522 DOI: 10.1016/J.Freeradbiomed.2017.01.006  0.763
2016 Tang WH, Wang Z, Li XS, Fan Y, Li DS, Wu Y, Hazen SL. Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus. Clinical Chemistry. PMID 27864387 DOI: 10.1373/Clinchem.2016.263640  0.327
2016 Senthong V, Wang Z, Fan Y, Wu Y, Hazen SL, Tang WH. Trimethylamine N-Oxide and Mortality Risk in Patients With Peripheral Artery Disease. Journal of the American Heart Association. 5. PMID 27792653 DOI: 10.1161/Jaha.116.004237  0.347
2016 Wang Z, DiDonato JA, Buffa JA, Comhair SA, Aronica MA, Dweik R, Lee NA, Lee JJ, Thomassen MJ, Kavuru M, Erzurum SC, Hazen SL. Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma. The Journal of Biological Chemistry. PMID 27587397 DOI: 10.1074/Jbc.M116.750034  0.596
2016 Iqbal AJ, Barr TJ, Taylor L, McNeill E, Manmadhan A, Recio C, Carmineri A, Brodermann MH, White GE, Cooper D, DiDonato JA, Hazen SL, Channon KM, Greaves DR, Fisher EA. Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo. Elife. 5. PMID 27572261 DOI: 10.7554/Elife.15190  0.614
2016 Gulshan K, Brubaker GD, Conger H, Wang S, Zhang R, Hazen SL, Smith JD. PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where it Mediates Apolipoprotein A1 Binding and Nascent HDL Assembly. Circulation Research. PMID 27514935 DOI: 10.1161/Circresaha.116.308856  0.303
2016 Tang WH, Hazen SL. Microbiome, trimethylamine N-oxide, and cardiometabolic disease. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 27490453 DOI: 10.1016/J.Trsl.2016.07.007  0.338
2016 Senthong V, Wang Z, Li XS, Fan Y, Wu Y, Wilson Tang WH, Hazen SL. Intestinal Microbiota-Generated Metabolite Trimethylamine-N-Oxide and 5-Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE-Like Patient Cohort. Journal of the American Heart Association. 5. PMID 27287696 DOI: 10.1161/Jaha.115.002816  0.327
2016 Senthong V, Li XS, Hudec T, Coughlin J, Wu Y, Levison B, Wang Z, Hazen SL, Tang WH. Plasma Trimethylamine N-Oxide, a Gut Microbe-Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden. Journal of the American College of Cardiology. 67: 2620-8. PMID 27256833 DOI: 10.1016/J.Jacc.2016.03.546  0.362
2016 Tang WW, Hazen SL. Dietary metabolism, gut microbiota and acute heart failure. Heart (British Cardiac Society). PMID 26980719 DOI: 10.1136/Heartjnl-2016-309268  0.337
2016 Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WH, DiDonato JA, ... ... Hazen SL, et al. Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk. Cell. PMID 26972052 DOI: 10.1016/J.Cell.2016.02.011  0.605
2016 Miller PE, Haberlen SA, Brown TT, Margolick JB, DiDonato JA, Hazen SL, Witt MD, Kingsley LA, Palella FJ, Budoff M, Jacobson LP, Post WS, Sears CL. Intestinal Microbiota-Produced Trimethylamine-N-oxide and its Association with Coronary Stenosis and HIV Serostatus. Journal of Acquired Immune Deficiency Syndromes (1999). PMID 26825179 DOI: 10.1097/Qai.0000000000000937  0.594
2016 Hartiala JA, Tang WH, Wang Z, Crow AL, Stewart AF, Roberts R, McPherson R, Erdmann J, Willenborg C, Hazen SL, Allayee H. Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease. Nature Communications. 7: 10558. PMID 26822151 DOI: 10.1038/Ncomms10558  0.337
2016 Gu X, Wu Z, Huang Y, Wagner MA, Baleanu-Gogonea C, Mehl RA, Buffa JA, DiDonato AJ, Hazen LB, Fox PL, Gogonea V, Parks JS, DiDonato JA, Hazen SL. A systematic investigation of structure/function requirements for the apolipoprotein A-I - lecithin cholesterol acyltransferase interaction loop of HDL. The Journal of Biological Chemistry. PMID 26797122 DOI: 10.1074/Jbc.M115.696088  0.765
2016 Organ CL, Otsuka H, Bhushan S, Wang Z, Bradley J, Trivedi R, Polhemus DJ, Tang WH, Wu Y, Hazen SL, Lefer DJ. Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. Circulation. Heart Failure. 9: e002314. PMID 26699388 DOI: 10.1161/Circheartfailure.115.002314  0.359
2016 Zeltzer SM, Wang X, Wang Z, Goparaju S, Dvorina N, Baldwin W, Hazen S, Tang W. Elevated Levels of Gut Microbe Metabolite Trimethylamine N-Oxide (TMAO) Levels Are Aassociated with Graft Arterial Disease Following Murine Heart Transplantation Journal of Heart and Lung Transplantation. 35. DOI: 10.1016/J.Healun.2016.01.564  0.303
2015 Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, ... ... Hazen SL, et al. Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis. Cell. 163: 1585-95. PMID 26687352 DOI: 10.1016/J.Cell.2015.11.055  0.632
2015 Gu X, Huang Y, Levison BS, Gerstenecker G, DiDonato AJ, Hazen LB, Lee J, Gogonea V, DiDonato JA, Hazen SL. Identification of critical paraoxonase 1 residues involved in high density lipoprotein interaction. The Journal of Biological Chemistry. PMID 26567339 DOI: 10.1074/Jbc.M115.678334  0.764
2015 Mani P, Uno K, St John J, Kupfer S, Perez A, Tuzcu EM, Hazen SL, Nissen SE, Nicholls SJ. Favorable Impact on LDL Particle Size in Response to Treatment With Pioglitazone is Associated With Less Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes. Journal of the American College of Cardiology. 66: 328-9. PMID 26184626 DOI: 10.1016/J.Jacc.2015.05.023  0.315
2015 Tang WH, Hazen SL. Reply: Trimethylamine-N-Oxide and Heart Failure. Journal of the American College of Cardiology. 66: 96-7. PMID 26139067 DOI: 10.1016/J.Jacc.2014.12.080  0.32
2015 Verbrugge FH, Tang WH, Hazen SL. Protein carbamylation and cardiovascular disease. Kidney International. PMID 26061545 DOI: 10.1038/Ki.2015.166  0.417
2015 Comhair SA, Grandon D, Khan A, Zhang R, Hazen SL, Erzurum SC. Coenzyme Q in asthma. American Journal of Respiratory and Critical Care Medicine. 191: 1336-8. PMID 26029840 DOI: 10.1164/Rccm.201412-2259Le  0.316
2015 Tang WH, Wang Z, Kennedy DJ, Wu Y, Buffa JA, Agatisa-Boyle B, Li XS, Levison BS, Hazen SL. Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circulation Research. 116: 448-55. PMID 25599331 DOI: 10.1161/Circresaha.116.305360  0.327
2015 Brown JM, Hazen SL. The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases. Annual Review of Medicine. 66: 343-59. PMID 25587655 DOI: 10.1146/Annurev-Med-060513-093205  0.306
2015 Gregory JC, Buffa JA, Org E, Wang Z, Levison BS, Zhu W, Wagner MA, Bennett BJ, Li L, DiDonato JA, Lusis AJ, Hazen SL. Transmission of atherosclerosis susceptibility with gut microbial transplantation. The Journal of Biological Chemistry. 290: 5647-60. PMID 25550161 DOI: 10.1074/Jbc.M114.618249  0.599
2015 Do R, Stitziel NO, Won HH, Jørgensen AB, Duga S, Angelica Merlini P, Kiezun A, Farrall M, Goel A, Zuk O, Guella I, Asselta R, Lange LA, Peloso GM, Auer PL, ... ... Hazen SL, et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 518: 102-6. PMID 25487149 DOI: 10.1038/Nature13917  0.313
2015 Senthong V, Wang Z, Wu Y, Tang WH, Hazen S. Elevated Plasma Trimethylamine-N-Oxide Is Associated With Poor Prognosis In Patients With Peripheral Artery Disease Journal of the American College of Cardiology. 65. DOI: 10.1016/S0735-1097(15)62076-9  0.371
2015 Senthong V, Li X, Coughlin J, Hudec T, Neale S, Li L, Wu Y, Wang Z, Hazen S, Tang WH. HIGHER PLASMA TRIMETHYLAMINE-N-OXIDE IS ASSOCIATED WITH GREATER ATHEROSCLEROTIC BURDEN QUANTIFIED BY THE SYNTAX SCORE Journal of the American College of Cardiology. 65: A1676. DOI: 10.1016/S0735-1097(15)61676-X  0.351
2015 Zeltzer SM, Wang Z, Li L, Coughlin J, Hudec T, Askar M, Taylor DO, Starling R, Hazen S, Tang WH. Dietary-Derived Trimethylamine N-Oxide (TMAO) Levels Are Associated With Coronary Allograft Vasculopathy Following Heart Transplantation Journal of Heart and Lung Transplantation. 34. DOI: 10.1016/J.Healun.2015.01.823  0.311
2014 Koeth RA, Levison BS, Culley MK, Buffa JA, Wang Z, Gregory JC, Org E, Wu Y, Li L, Smith JD, Tang WH, DiDonato JA, Lusis AJ, Hazen SL. γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metabolism. 20: 799-812. PMID 25440057 DOI: 10.1016/J.Cmet.2014.10.006  0.6
2014 Ali ZA, de Jesus Perez V, Yuan K, Orcholski M, Pan S, Qi W, Chopra G, Adams C, Kojima Y, Leeper NJ, Qu X, Zaleta-Rivera K, Kato K, Yamada Y, Oguri M, ... ... Hazen SL, et al. Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1. The Journal of Clinical Investigation. 124: 5159-74. PMID 25401476 DOI: 10.1172/Jci77484  0.308
2014 Stitziel NO, Won HH, Morrison AC, Peloso GM, Do R, Lange LA, Fontanillas P, Gupta N, Duga S, Goel A, Farrall M, Saleheen D, Ferrario P, König I, ... ... Hazen SL, et al. Inactivating mutations in NPC1L1 and protection from coronary heart disease. The New England Journal of Medicine. 371: 2072-82. PMID 25390462 DOI: 10.1056/Nejmoa1405386  0.336
2014 Tang WH, Hazen SL. The contributory role of gut microbiota in cardiovascular disease. The Journal of Clinical Investigation. 124: 4204-11. PMID 25271725 DOI: 10.1172/Jci72331  0.361
2014 Hazen SL, Brown JM. Eggs as a dietary source for gut microbial production of trimethylamine-N-oxide. The American Journal of Clinical Nutrition. 100: 741-3. PMID 25080455 DOI: 10.3945/Ajcn.114.094458  0.407
2014 Hale JS, Otvos B, Sinyuk M, Alvarado AG, Hitomi M, Stoltz K, Wu Q, Flavahan W, Levison B, Johansen ML, Schmitt D, Neltner JM, Huang P, Ren B, Sloan AE, ... ... Hazen SL, et al. Cancer stem cell-specific scavenger receptor 36 drives glioblastoma progression. Stem Cells (Dayton, Ohio). 32: 1746-58. PMID 24737733 DOI: 10.1002/Stem.1716  0.572
2014 DiDonato JA, Aulak K, Huang Y, Wagner M, Gerstenecker G, Topbas C, Gogonea V, DiDonato AJ, Tang WH, Mehl RA, Fox PL, Plow EF, Smith JD, Fisher EA, Hazen SL. Site-specific nitration of apolipoprotein A-I at tyrosine 166 is both abundant within human atherosclerotic plaque and dysfunctional. The Journal of Biological Chemistry. 289: 10276-92. PMID 24558038 DOI: 10.1074/Jbc.M114.556506  0.793
2014 Wang Z, Tang WH, Buffa JA, Fu X, Britt EB, Koeth RA, Levison BS, Fan Y, Wu Y, Hazen SL. Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. European Heart Journal. 35: 904-10. PMID 24497336 DOI: 10.1093/Eurheartj/Ehu002  0.354
2014 Alkhouri N, Berk M, Yerian L, Lopez R, Chung YM, Zhang R, McIntyre TM, Feldstein AE, Hazen SL. OxNASH score correlates with histologic features and severity of nonalcoholic fatty liver disease. Digestive Diseases and Sciences. 59: 1617-24. PMID 24464211 DOI: 10.1007/S10620-014-3031-8  0.305
2014 Huang Y, DiDonato JA, Levison BS, Schmitt D, Li L, Wu Y, Buffa J, Kim T, Gerstenecker GS, Gu X, Kadiyala CS, Wang Z, Culley MK, Hazen JE, Didonato AJ, ... ... Hazen SL, et al. An abundant dysfunctional apolipoprotein A1 in human atheroma. Nature Medicine. 20: 193-203. PMID 24464187 DOI: 10.1038/Nm.3459  0.782
2014 Hewing B, Parathath S, Barrett T, Chung WK, Astudillo YM, Hamada T, Ramkhelawon B, Tallant TC, Yusufishaq MS, Didonato JA, Huang Y, Buffa J, Berisha SZ, Smith JD, Hazen SL, et al. Effects of native and myeloperoxidase-modified apolipoprotein a-I on reverse cholesterol transport and atherosclerosis in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 779-89. PMID 24407029 DOI: 10.1161/Atvbaha.113.303044  0.634
2014 Raymond C, Cho L, Rocco M, Hazen SL. New cholesterol guidelines: worth the wait? Cleveland Clinic Journal of Medicine. 81: 11-9. PMID 24391101 DOI: 10.3949/Ccjm.81A.13161  0.305
2014 Feig JE, Hewing B, Smith JD, Hazen SL, Fisher EA. High-density lipoprotein and atherosclerosis regression: evidence from preclinical and clinical studies. Circulation Research. 114: 205-13. PMID 24385513 DOI: 10.1161/Circresaha.114.300760  0.382
2014 Brown JM, Hazen SL. Metaorganismal nutrient metabolism as a basis of cardiovascular disease. Current Opinion in Lipidology. 25: 48-53. PMID 24362355 DOI: 10.1097/Mol.0000000000000036  0.33
2014 Christian AJ, Lin H, Alferiev IS, Connolly JM, Ferrari G, Hazen SL, Ischiropoulos H, Levy RJ. The susceptibility of bioprosthetic heart valve leaflets to oxidation. Biomaterials. 35: 2097-102. PMID 24360721 DOI: 10.1016/J.Biomaterials.2013.11.045  0.319
2014 Kennedy DJ, Fan Y, Wu Y, Pepoy M, Hazen SL, Tang WH. Plasma ceruloplasmin, a regulator of nitric oxide activity, and incident cardiovascular risk in patients with CKD. Clinical Journal of the American Society of Nephrology : Cjasn. 9: 462-7. PMID 24311705 DOI: 10.2215/Cjn.07720713  0.333
2014 Lathia JD, Hale JS, Sloan AE, Gladson CL, Hazen SL, Horbinski C, Rich JN, Brown JM. INTEGRATION OF CANCER STEM CELL MAINTENANCE AND LIPID METABOLISM BY SCAVENGER RECEPTORS Neuro-Oncology. 16: iii17-iii17. DOI: 10.1093/Neuonc/Nou206.62  0.304
2014 DiDonato JA, Aulak K, Huang Y, Wagner M, Gerstenecker G, Topbas C, Gogonea V, DiDonato AJ, Tang WW, Mehl RA, Fox PL, Plow EF, Smith JD, Fisher EA, Hazen SL. Site-specific nitration of apolipoprotein A-I at tyrosine 166 is both abundant within human atherosclerotic plaque and dysfunctional Nitric Oxide. 42: 105-106. DOI: 10.1016/J.Niox.2014.09.024  0.771
2013 Gulshan K, Brubaker G, Wang S, Hazen SL, Smith JD. Sphingomyelin depletion impairs anionic phospholipid inward translocation and induces cholesterol efflux. The Journal of Biological Chemistry. 288: 37166-79. PMID 24220029 DOI: 10.1074/Jbc.M113.512244  0.352
2013 DiDonato JA, Huang Y, Aulak KS, Even-Or O, Gerstenecker G, Gogonea V, Wu Y, Fox PL, Tang WH, Plow EF, Smith JD, Fisher EA, Hazen SL. Function and distribution of apolipoprotein A1 in the artery wall are markedly distinct from those in plasma. Circulation. 128: 1644-55. PMID 23969698 DOI: 10.1161/Circulationaha.113.002624  0.755
2013 Huang Y, Wu Z, Riwanto M, Gao S, Levison BS, Gu X, Fu X, Wagner MA, Besler C, Gerstenecker G, Zhang R, Li XM, DiDonato AJ, Gogonea V, Tang WH, ... ... Hazen SL, et al. Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex. The Journal of Clinical Investigation. 123: 3815-28. PMID 23908111 DOI: 10.1172/Jci67478  0.778
2013 Zamanian-Daryoush M, Lindner D, Tallant TC, Wang Z, Buffa J, Klipfell E, Parker Y, Hatala D, Parsons-Wingerter P, Rayman P, Yusufishaq MS, Fisher EA, Smith JD, Finke J, DiDonato JA, ... Hazen SL, et al. The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects. The Journal of Biological Chemistry. 288: 21237-52. PMID 23720750 DOI: 10.1074/jbc.M113.468967  0.525
2013 Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. The New England Journal of Medicine. 368: 1575-84. PMID 23614584 DOI: 10.1056/Nejmoa1109400  0.355
2013 Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, ... ... Hazen SL, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature Medicine. 19: 576-85. PMID 23563705 DOI: 10.1038/Nm.3145  0.633
2013 Wang S, Gulshan K, Brubaker G, Hazen SL, Smith JD. ABCA1 mediates unfolding of apolipoprotein AI N terminus on the cell surface before lipidation and release of nascent high-density lipoprotein. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1197-205. PMID 23559627 DOI: 10.1161/Atvbaha.112.301195  0.333
2013 Kennedy DJ, Tang WH, Fan Y, Wu Y, Mann S, Pepoy M, Hazen SL. Diminished antioxidant activity of high-density lipoprotein-associated proteins in chronic kidney disease. Journal of the American Heart Association. 2: e000104. PMID 23557751 DOI: 10.1161/Jaha.112.000104  0.326
2013 Li XM, Tang WH, Mosior MK, Huang Y, Wu Y, Matter W, Gao V, Schmitt D, Didonato JA, Fisher EA, Smith JD, Hazen SL. Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1696-705. PMID 23520163 DOI: 10.1161/Atvbaha.113.301373  0.645
2013 Levison BS, Zhang R, Wang Z, Fu X, DiDonato JA, Hazen SL. Quantification of fatty acid oxidation products using online high-performance liquid chromatography tandem mass spectrometry. Free Radical Biology & Medicine. 59: 2-13. PMID 23499838 DOI: 10.1016/J.Freeradbiomed.2013.03.001  0.614
2013 Tang WH, Shrestha K, Tong W, Wang Z, Troughton RW, Borowski AG, Klein AL, Hazen SL. Nitric oxide bioavailability and adiponectin production in chronic systolic heart failure: relation to severity of cardiac dysfunction. Translational Research : the Journal of Laboratory and Clinical Medicine. 162: 26-33. PMID 23499315 DOI: 10.1016/J.Trsl.2013.02.005  0.311
2013 Koeth RA, Kalantar-Zadeh K, Wang Z, Fu X, Tang WH, Hazen SL. Protein carbamylation predicts mortality in ESRD. Journal of the American Society of Nephrology : Jasn. 24: 853-61. PMID 23431074 DOI: 10.1681/Asn.2012030254  0.302
2013 Gogonea V, Gerstenecker GS, Wu Z, Lee X, Topbas C, Wagner MA, Tallant TC, Smith JD, Callow P, Pipich V, Malet H, Schoehn G, DiDonato JA, Hazen SL. The low-resolution structure of nHDL reconstituted with DMPC with and without cholesterol reveals a mechanism for particle expansion. Journal of Lipid Research. 54: 966-83. PMID 23349207 DOI: 10.1194/Jlr.M032763  0.78
2013 Bennett BJ, de Aguiar Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metabolism. 17: 49-60. PMID 23312283 DOI: 10.1016/J.Cmet.2012.12.011  0.333
2013 Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson A, ... ... Hazen SL, et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nature Genetics. 45: 25-33. PMID 23202125 DOI: 10.1038/Ng.2480  0.308
2013 Tang WHW, Wang Z, Wu Y, Fan Y, Koeth RA, Hazen S. Gut Flora Metabolite Trimethylamine N-Oxide Predicts Incident Cardiovascular Risks In Both Stable Non-Diabetics And Diabetic Subjects Journal of the American College of Cardiology. 61. DOI: 10.1016/S0735-1097(13)61398-4  0.323
2013 Tang WHW, Wang Z, Wu Y, Fan Y, Koeth RA, Hazen S. Prognostic Value Of Elevated Levels Of Intestinal Microflora-Generated Metabolite Trimethylamine N-Oxide In Patients With Heart Failure: The Gut Hypothesis Revisited Journal of the American College of Cardiology. 61. DOI: 10.1016/S0735-1097(13)60750-0  0.341
2013 Turner R, Wu Y, Li L, Tang W, Hazen SL, Kettle A. PSS147 - Uric Acid Oxidation as a Biomarker of Cardiovascular Disease Free Radical Biology and Medicine. 65. DOI: 10.1016/J.Freeradbiomed.2013.10.566  0.315
2012 Fisher EA, Feig JE, Hewing B, Hazen SL, Smith JD. High-density lipoprotein function, dysfunction, and reverse cholesterol transport. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 2813-20. PMID 23152494 DOI: 10.1161/Atvbaha.112.300133  0.379
2012 Thomson L, Tenopoulou M, Lightfoot R, Tsika E, Parastatidis I, Martinez M, Greco TM, Doulias PT, Wu Y, Tang WH, Hazen SL, Ischiropoulos H. Immunoglobulins against tyrosine-nitrated epitopes in coronary artery disease. Circulation. 126: 2392-401. PMID 23081989 DOI: 10.1161/Circulationaha.112.103796  0.313
2012 Holleboom AG, Daniil G, Fu X, Zhang R, Hovingh GK, Schimmel AW, Kastelein JJ, Stroes ES, Witztum JL, Hutten BA, Tsimikas S, Hazen SL, Chroni A, Kuivenhoven JA. Lipid oxidation in carriers of lecithin:cholesterol acyltransferase gene mutations. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 3066-75. PMID 23023370 DOI: 10.1161/Atvbaha.112.255711  0.361
2012 Hazen SL. New lipid and lipoprotein targets for the treatment of cardiometabolic diseases Journal of Lipid Research. 53: 1719-1721. PMID 22766886 DOI: 10.1194/Jlr.E030205  0.376
2012 Granzin J, Huang Y, Topbas C, Huang W, Wu Z, Misra S, Hazen SL, Blanton RE, Lee X, Weiergräber OH. Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain. Acta Crystallographica. Section D, Biological Crystallography. 68: 686-94. PMID 22683791 DOI: 10.1107/S0907444912008372  0.763
2012 Martinez M, Cuker A, Mills A, Lightfoot R, Fan Y, Tang WH, Hazen SL, Ischiropoulos H. Nitrated fibrinogen is a biomarker of oxidative stress in venous thromboembolism. Free Radical Biology & Medicine. 53: 230-6. PMID 22580301 DOI: 10.1016/J.Freeradbiomed.2012.05.004  0.337
2012 Zein CO, Lopez R, Fu X, Kirwan JP, Yerian LM, McCullough AJ, Hazen SL, Feldstein AE. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism. Hepatology (Baltimore, Md.). 56: 1291-9. PMID 22505276 DOI: 10.1002/Hep.25778  0.366
2012 Suzuki M, Tsujikawa M, Itabe H, Du ZJ, Xie P, Matsumura N, Fu X, Zhang R, Sonoda KH, Egashira K, Hazen SL, Kamei M. Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration. Journal of Cell Science. 125: 2407-15. PMID 22357958 DOI: 10.1242/Jcs.097683  0.323
2012 Tang WH, Wu Y, Hartiala J, Fan Y, Stewart AF, Roberts R, McPherson R, Fox PL, Allayee H, Hazen SL. Clinical and genetic association of serum ceruloplasmin with cardiovascular risk. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 516-22. PMID 22075249 DOI: 10.1161/Atvbaha.111.237040  0.335
2012 Grallert H, Dupuis J, Bis JC, Dehghan A, Barbalic M, Baumert J, Lu C, Smith NL, Uitterlinden AG, Roberts R, Khuseyinova N, Schnabel RB, Rice KM, Rivadeneira F, Hoogeveen RC, ... ... Hazen SL, et al. Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. European Heart Journal. 33: 238-51. PMID 22003152 DOI: 10.1093/Eurheartj/Ehr372  0.308
2012 Shao Z, Huang Y, Moravec CS, Hazen SL, Tang WW. Increased Oxidized Apolipoprotein A1 Levels in the Failing Human Heart Journal of Cardiac Failure. 18: S17. DOI: 10.1016/J.Cardfail.2012.06.057  0.314
2011 Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, ... ... Hazen SL, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 472: 57-63. PMID 21475195 DOI: 10.1038/Nature09922  0.645
2011 Wedes SH, Wu W, Comhair SA, McDowell KM, DiDonato JA, Erzurum SC, Hazen SL. Urinary bromotyrosine measures asthma control and predicts asthma exacerbations in children. The Journal of Pediatrics. 159: 248-55.e1. PMID 21392781 DOI: 10.1016/J.Jpeds.2011.01.029  0.72
2011 Wu Z, Gogonea V, Lee X, May RP, Pipich V, Wagner MA, Undurti A, Tallant TC, Baleanu-Gogonea C, Charlton F, Ioffe A, DiDonato JA, Rye KA, Hazen SL. The low resolution structure of ApoA1 in spherical high density lipoprotein revealed by small angle neutron scattering. The Journal of Biological Chemistry. 286: 12495-508. PMID 21292766 DOI: 10.1074/Jbc.M110.209130  0.792
2011 Tang WH, Wu Y, Mann S, Pepoy M, Shrestha K, Borowski AG, Hazen SL. Diminished antioxidant activity of high-density lipoprotein-associated proteins in systolic heart failure. Circulation. Heart Failure. 4: 59-64. PMID 21062973 DOI: 10.1161/Circheartfailure.110.958348  0.349
2010 McIntyre TM, Hazen SL. Lipid oxidation and cardiovascular disease: introduction to a review series. Circulation Research. 107: 1167-9. PMID 21071714 DOI: 10.1161/Circresaha.110.224618  0.396
2010 Hazen SL. Neutrophils, hypercholesterolemia, and atherogenesis Circulation. 122: 1786-1788. PMID 20956213 DOI: 10.1161/Circulationaha.110.984062  0.36
2010 Robinet P, Wang Z, Hazen SL, Smith JD. A simple and sensitive enzymatic method for cholesterol quantification in macrophages and foam cells Journal of Lipid Research. 51: 3364-3369. PMID 20688754 DOI: 10.1194/Jlr.D007336  0.339
2010 Gogonea V, Wu Z, Lee X, Pipich V, Li XM, Ioffe AI, Didonato JA, Hazen SL. Congruency between biophysical data from multiple platforms and molecular dynamics simulation of the double-super helix model of nascent high-density lipoprotein. Biochemistry. 49: 7323-43. PMID 20687589 DOI: 10.1021/Bi100588A  0.778
2010 Nicholls SJ, Tang WH, Scoffone H, Brennan DM, Hartiala J, Allayee H, Hazen SL. Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy. Journal of Lipid Research. 51: 3055-61. PMID 20601648 DOI: 10.1194/Jlr.M008961  0.306
2010 Hazen S. HDL structure, function, therapeutics, and imaging Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 138. PMID 20089949 DOI: 10.1161/Atvbaha.109.201897  0.339
2010 Thomas CP, Morgan LT, Maskrey BH, Murphy RC, Kühn H, Hazen SL, Goodall AH, Hamali HA, Collins PW, O'Donnell VB. Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation. The Journal of Biological Chemistry. 285: 6891-903. PMID 20061396 DOI: 10.1074/Jbc.M109.078428  0.344
2010 Tang WHW, Wu Y, Nicholls SJ, Hazen SL. Diminished Paroxonase-1 Activity, A Marker Of Dysfunctional High-Density Lipoprotein Cholesterol, Reclassifies Stable Cardiac Patients At Higher Risk For Developing Major Adverse Cardiac Events Journal of the American College of Cardiology. 55. DOI: 10.1016/S0735-1097(10)60914-X  0.327
2010 Nicholls SJ, Tang WHW, Brennan DM, Hazen SL. Lipoprotein (A) Levels Predict The Extent Of Obstructive Disease And Longterm Cardiovascular Outcome In Patients Undergoing Coronary Angiography With Suboptimal Lipid Contorol Journal of the American College of Cardiology. 55. DOI: 10.1016/S0735-1097(10)60499-8  0.329
2009 Wedes SH, Khatri SB, Zhang R, Wu W, Comhair SA, Wenzel S, Teague WG, Israel E, Erzurum SC, Hazen SL. Noninvasive markers of airway inflammation in asthma. Clinical and Translational Science. 2: 112-7. PMID 20234847 DOI: 10.1111/J.1752-8062.2009.00095.X  0.595
2009 Wu Z, Gogonea V, Lee X, Wagner MA, Li XM, Huang Y, Undurti A, May RP, Haertlein M, Moulin M, Gutsche I, Zaccai G, Didonato JA, Hazen SL. Double superhelix model of high density lipoprotein. The Journal of Biological Chemistry. 284: 36605-19. PMID 19812036 DOI: 10.1074/Jbc.M109.039537  0.798
2009 Undurti A, Huang Y, Lupica JA, Smith JD, DiDonato JA, Hazen SL. Modification of high density lipoprotein by myeloperoxidase generates a pro-inflammatory particle. The Journal of Biological Chemistry. 284: 30825-35. PMID 19726691 DOI: 10.1074/Jbc.M109.047605  0.65
2009 Wang Z, Tang WHW, Cho L, Brennan DM, Hazen SL. Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: Potential mechanisms beyond nitric oxide synthase inhibition Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 1383-1391. PMID 19542023 DOI: 10.1161/Atvbaha.109.185645  0.336
2009 Tang WHW, Wang Z, Cho L, Brennan DM, Hazen SL. Diminished Global Arginine Bioavailability and Increased Arginine Catabolism as Metabolic Profile of Increased Cardiovascular Risk Journal of the American College of Cardiology. 53: 2061-2067. PMID 19477356 DOI: 10.1016/J.Jacc.2009.02.036  0.351
2009 Tang WH, Katz R, Brennan ML, Aviles RJ, Tracy RP, Psaty BM, Hazen SL. Usefulness of myeloperoxidase levels in healthy elderly subjects to predict risk of developing heart failure. The American Journal of Cardiology. 103: 1269-74. PMID 19406270 DOI: 10.1016/J.Amjcard.2009.01.026  0.303
2009 Kato GJ, Wang Z, MacHado RF, Blackwelder WC, Taylor VI JG, Hazen SL. Endogenous nitric oxide synthase inhibitors in sickle cell disease: Abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death British Journal of Haematology. 145: 506-513. PMID 19344390 DOI: 10.1111/J.1365-2141.2009.07658.X  0.319
2009 Shishehbor MH, Hazen SL. JUPITER to earth: A statin helps people with normal LDL-C and high hs-CRP, but what does it mean? Cleveland Clinic Journal of Medicine. 76: 37-44. PMID 19122109 DOI: 10.3949/Ccjm.75A.08105  0.322
2009 Nicholls SJ, Hazen SL. Myeloperoxidase, modified lipoproteins, and atherogenesis Journal of Lipid Research. 50. PMID 19091698 DOI: 10.1194/Jlr.R800086-Jlr200  0.378
2008 Sehayek E, Hazen SL. Cholesterol Absorption From the Intestine Is a Major Determinant of Reverse Cholesterol Transport From Peripheral Tissue Macrophages Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1296-1297. PMID 18420997 DOI: 10.1161/Atvbaha.108.165803  0.301
2008 Bhattacharyya T, Nicholls SJ, Topol EJ, Zhang R, Yang X, Schmitt D, Fu X, Shao M, Brennan DM, Ellis SG, Brennan ML, Allayee H, Lusis AJ, Hazen SL. Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. Jama. 299: 1265-76. PMID 18349088 DOI: 10.1001/Jama.299.11.1265  0.303
2008 Hazen SL. Oxidized phospholipids as endogenous pattern recognition ligands in innate immunity. Journal of Biological Chemistry. 283: 15527-15531. PMID 18285328 DOI: 10.1074/Jbc.R700054200  0.345
2008 Ioachimescu AG, Brennan DM, Hoar BM, Hazen SL, Hoogwerf BJ. Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system (PreCIS) database cohort study. Arthritis & Rheumatism. 58: 623-630. PMID 18240236 DOI: 10.1002/Art.23121  0.335
2008 Chen X, Zhang W, Laird J, Hazen SL, Salomon RG. Polyunsaturated phospholipids promote the oxidation and fragmentation of gamma-hydroxyalkenals: formation and reactions of oxidatively truncated ether phospholipids. Journal of Lipid Research. 49: 832-46. PMID 18165704 DOI: 10.1194/Jlr.M700598-Jlr200  0.354
2008 Greenberg ME, Li XM, Gugiu BG, Gu X, Qin J, Salomon RG, Hazen SL. The lipid whisker model of the structure of oxidized cell membranes. The Journal of Biological Chemistry. 283: 2385-96. PMID 18045864 DOI: 10.1074/Jbc.M707348200  0.317
2008 Tardif JC, Grégoire J, L'Allier PL, Ibrahim R, Anderson TJ, Reeves F, Title LM, Schampaert E, LeMay M, Lespérance J, Scott R, Guertin MC, Brennan ML, Hazen SL, Bertrand OF, et al. Effects of the antioxidant succinobucol (AGI-1067) on human atherosclerosis in a randomized clinical trial. Atherosclerosis. 197: 480-6. PMID 17214993 DOI: 10.1016/J.Atherosclerosis.2006.11.039  0.305
2008 Evans TA, Siedlak SL, Lu L, Fu X, Wang Z, McGinnis WR, Fakhoury E, Castellani RJ, Hazen SL, Walsh WJ, Lewis AT, Salomon RG, Smith MA, Perry G, Zhu X. The Autistic Phenotype Exhibits a Remarkably Localized Modification of Brain Protein by Products of Free Radical-Induced Lipid Oxidation American Journal of Biochemistry and Biotechnology. 4: 61-72. DOI: 10.3844/Ajbbsp.2008.61.72  0.314
2008 Wu Z, Wagner MA, Zheng L, Parks JS, Shy JM, Smith JD, Gogonea V, Hazen SL. Corrigendum: The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction (Nature Structural and Molecular Biology (2007) 14, (861-868)) Nature Structural and Molecular Biology. 15: 651. DOI: 10.1038/Nsmb0608-651B  0.638
2008 Wu Z, Wagner MA, Zheng L, Parks JS, Shy III JM, Smith JD, Gogonea V, Hazen SL. Erratum: Corrigendum: The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction Nature Structural & Molecular Biology. 15: 330-330. DOI: 10.1038/Nsmb0308-330  0.637
2008 Bhattacharyya T, Zhang R, Yerian LM, McCullough AJ, Hazen SL, Feldstein AE. 59 Mass Spectrometric Detection of Lipid Oxidation Products in Murine and Human Nonalcoholic Fatty Liver Disease Gastroenterology. 134. DOI: 10.1016/S0016-5085(08)63517-9  0.327
2007 Nicholls SJ, Wang Z, Koeth R, Levison B, Delfraino B, Dzavik V, Griffith OW, Hathaway D, Panza JA, Nissen SE, Hochman JS, Hazen SL. Metabolic profiling of arginine and nitric oxide pathways predicts hemodynamic abnormalities and mortality in patients with cardiogenic shock after acute myocardial infarction Circulation. 116: 2315-2324. PMID 17967979 DOI: 10.1161/Circulationaha.107.693986  0.301
2007 Cannady SB, Batra PS, Leahy R, Citardi MJ, Janocha A, Ricci K, Comhair SAA, Bodine M, Wang Z, Hazen SL, Erzurum SC. Signal transduction and oxidative processes in sinonasal polyposis Journal of Allergy and Clinical Immunology. 120: 1346-1353. PMID 17935768 DOI: 10.1016/J.Jaci.2007.07.067  0.315
2007 Wang Z, Nicholls SJ, Rodriguez ER, Kummu O, Hörkkö S, Barnard J, Reynolds WF, Topol EJ, DiDonato JA, Hazen SL. Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nature Medicine. 13: 1176-84. PMID 17828273 DOI: 10.1038/Nm1637  0.648
2007 Podrez EA, Byzova TV, Febbraio M, Salomon RG, Ma Y, Valiyaveettil M, Poliakov E, Sun M, Finton PJ, Curtis BR, Chen J, Zhang R, Silverstein RL, Hazen SL. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nature Medicine. 13: 1086-95. PMID 17721545 DOI: 10.1038/Nm1626  0.325
2007 Wu Z, Wagner MA, Zheng L, Parks JS, Shy JM, Smith JD, Gogonea V, Hazen SL. The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction. Nature Structural & Molecular Biology. 14: 861-8. PMID 17676061 DOI: 10.1038/Nsmb1284  0.672
2007 Lee JC, Weissglas-Volkov D, Kyttälä M, Sinsheimer JS, Jokiaho A, de Bruin TW, Lusis AJ, Brennan ML, van Greevenbroek MM, van der Kallen CJ, Hazen SL, Pajukanta P. USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 2222-7. PMID 17673701 DOI: 10.1161/Atvbaha.107.151530  0.309
2007 Meuwese MC, Stroes ESG, Hazen SL, Miert JNv, Kuivenhoven JA, Schaub RG, Wareham NJ, Luben R, Kastelein JJP, Khaw KT, Boekholdt SM. Serum Myeloperoxidase Levels Are Associated With the Future Risk of Coronary Artery Disease in Apparently Healthy Individuals: The EPIC-Norfolk Prospective Population Study Journal of the American College of Cardiology. 50: 159-165. PMID 17616301 DOI: 10.1016/J.Jacc.2007.03.033  0.367
2007 Parastatidis I, Thomson L, Fries DM, Moore RE, Tohyama J, Fu X, Hazen SL, Heijnen HF, Dennehy MK, Liebler DC, Rader DJ, Ischiropoulos H. Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient mice. Circulation Research. 101: 368-76. PMID 17615369 DOI: 10.1161/Circresaha.107.157537  0.341
2007 Bhatt DL, Chew DP, Grines C, Mukherjee D, Leesar M, Gilchrist IC, Corbelli JC, Blankenship JC, Eres A, Steinhubl S, Tan WA, Resar JR, AlMahameed A, Abdel-Latif A, Tang HW, ... ... Hazen SL, et al. Peroxisome proliferator-activated receptor γ agonists for the Prevention of Adverse events following percutaneous coronary Revascularization-results of the PPAR Study American Heart Journal. 154: 137-143. PMID 17584566 DOI: 10.1016/J.Ahj.2007.03.029  0.319
2007 Nicholls SJ, Wolski K, Sipahi I, Schoenhagen P, Crowe T, Kapadia SR, Hazen SL, Tuzcu EM, Nissen SE. Rate of progression of coronary atherosclerotic plaque in women. Journal of the American College of Cardiology. 49: 1546-51. PMID 17418293 DOI: 10.1016/J.Jacc.2006.12.039  0.309
2007 Nicholls SJ, Tuzcu EM, Sipahi I, Grasso AW, Schoenhagen P, Hu T, Wolski K, Crowe T, Desai MY, Hazen SL, Kapadia SR, Nissen SE. Statins, High-Density Lipoprotein Cholesterol, and Regression of Coronary Atherosclerosis Jama. 297: 499-508. PMID 17284700 DOI: 10.1001/Jama.297.5.499  0.342
2007 Thomson L, Christie J, Vadseth C, Lanken PN, Fu X, Hazen SL, Ischiropoulos H. Identification of immunoglobulins that recognize 3-nitrotyrosine in patients with acute lung injury after major trauma. American Journal of Respiratory Cell and Molecular Biology. 36: 152-7. PMID 17023686 DOI: 10.1165/Rcmb.2006-0288Sm  0.312
2007 Brennan ML, Hazen SL. Myeloperoxidase: A mechanistically linked biomarker for cardiovascular disease Current Cardiovascular Risk Reports. 1: 58-65. DOI: 10.1007/S12170-007-0010-Z  0.32
2006 Shishehbor MH, Zhang R, Medina H, Brennan ML, Brennan DM, Ellis SG, Topol EJ, Hazen SL. Systemic elevations of free radical oxidation products of arachidonic acid are associated with angiographic evidence of coronary artery disease. Free Radical Biology & Medicine. 41: 1678-83. PMID 17145556 DOI: 10.1016/J.Freeradbiomed.2006.09.001  0.358
2006 Citardi MJ, Song W, Batra PS, Lanza DC, Hazen SL. Characterization of oxidative pathways in chronic rhinosinusitis and sinonasal polyposis. American Journal of Roentgenology. 20: 353-359. PMID 16871943 DOI: 10.2500/Ajr.2006.20.2858  0.324
2006 Nicholls SJ, Tuzcu EM, Sipahi I, Schoenhagen P, Hazen SL, Ntanios F, Wun CC, Nissen SE. Effects of Obesity on Lipid-Lowering, Anti-Inflammatory, and Antiatherosclerotic Benefits of Atorvastatin or Pravastatin in Patients With Coronary Artery Disease (from the REVERSAL Study) American Journal of Cardiology. 97: 1553-1557. PMID 16728212 DOI: 10.1016/J.Amjcard.2005.12.042  0.353
2006 Lockwood SF, Penn MS, Hazen SL, Bikádi Z, Zsila F. The effects of oral Cardax (disodium disuccinate astaxanthin) on multiple independent oxidative stress markers in a mouse peritoneal inflammation model: influence on 5-lipoxygenase in vitro and in vivo. Life Sciences. 79: 162-74. PMID 16466747 DOI: 10.1016/J.Lfs.2005.12.052  0.338
2006 Kato GJ, Zeneng W, Taylor JG, Machado RF, Blackwelder WC, Gladwin MT, Hazen SL. Arginine Metabolite Profiling in Sickle Cell Disease: Abnormal Levels and Correlations with Pulmonary Hypertension, Desaturation, Hemolysis and Organ Dysfunction. Blood. 108: 1205-1205. DOI: 10.1182/Blood.V108.11.1205.1205  0.341
2005 Nicholls SJ, Shen Z, Fu X, Levison BS, Hazen SL. Quantification of 3-nitrotyrosine levels using a benchtop ion trap mass spectrometry method. Methods in Enzymology. 396: 245-66. PMID 16291237 DOI: 10.1016/S0076-6879(05)96022-9  0.325
2005 Vasilyev N, Williams T, Brennan ML, Unzek S, Zhou X, Heinecke JW, Spitz DR, Topol EJ, Hazen SL, Penn MS. Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction. Circulation. 112: 2812-20. PMID 16267254 DOI: 10.1161/Circulationaha.105.542340  0.3
2005 Nicholls SJ, Zheng L, Hazen SL. Formation of dysfunctional high-density lipoprotein by myeloperoxidase. Trends in Cardiovascular Medicine. 15: 212-9. PMID 16182131 DOI: 10.1016/J.Tcm.2005.06.004  0.305
2005 Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sachdev V, Hazen SL, Vichinsky EP, Morris SM, Gladwin MT. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. Jama. 294: 81-90. PMID 15998894 DOI: 10.1001/Jama.294.1.81  0.305
2005 Nicholls SJ, Hazen SL. Myeloperoxidase and Cardiovascular Disease Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 1102-1111. PMID 15790935 DOI: 10.1161/01.Atv.0000163262.83456.6D  0.347
2005 Zheng L, Settle M, Brubaker G, Schmitt D, Hazen SL, Smith JD, Kinter M. Localization of nitration and chlorination sites on apolipoprotein A-I catalyzed by myeloperoxidase in human atheroma and associated oxidative impairment in ABCA1-dependent cholesterol efflux from macrophages. The Journal of Biological Chemistry. 280: 38-47. PMID 15498770 DOI: 10.1074/Jbc.M407019200  0.412
2004 Zheng L, Nukuna B, Brennan ML, Sun M, Goormastic M, Settle M, Schmitt D, Fu X, Thomson L, Fox PL, Ischiropoulos H, Smith JD, Kinter M, Hazen SL. Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. The Journal of Clinical Investigation. 114: 529-41. PMID 15314690 DOI: 10.1172/Jci21109  0.326
2004 Hazen SL. Myeloperoxidase and Plaque Vulnerability Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 1143-1146. PMID 15237089 DOI: 10.1161/01.Atv.0000135267.82813.52  0.354
2004 Koeck T, Fu X, Hazen SL, Crabb JW, Stuehr DJ, Aulak KS. Rapid and selective oxygen-regulated protein tyrosine denitration and nitration in mitochondria. The Journal of Biological Chemistry. 279: 27257-62. PMID 15084586 DOI: 10.1074/Jbc.M401586200  0.3
2004 Shishehbor MH, Hazen SL. Inflammatory and oxidative markers in atherosclerosis: relationship to outcome. Current Atherosclerosis Reports. 6: 243-250. PMID 15068750 DOI: 10.1007/S11883-004-0038-1  0.35
2004 Vadseth C, Souza JM, Thomson L, Seagraves A, Nagaswami C, Scheiner T, Torbet J, Vilaire G, Bennett JS, Murciano JC, Muzykantov V, Penn MS, Hazen SL, Weisel JW, Ischiropoulos H. Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species. The Journal of Biological Chemistry. 279: 8820-6. PMID 14681238 DOI: 10.1074/Jbc.M306101200  0.366
2003 Poliakov E, Brennan ML, Macpherson J, Zhang R, Sha W, Narine L, Salomon RG, Hazen SL. Isolevuglandins, a novel class of isoprostenoid derivatives, function as integrated sensors of oxidant stress and are generated by myeloperoxidase in vivo. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 2209-20. PMID 14656983 DOI: 10.1096/Fj.03-0086Com  0.354
2003 Thukkani AK, McHowat J, Hsu FF, Brennan ML, Hazen SL, Ford DA. Identification of alpha-chloro fatty aldehydes and unsaturated lysophosphatidylcholine molecular species in human atherosclerotic lesions. Circulation. 108: 3128-33. PMID 14638540 DOI: 10.1161/01.Cir.0000104564.01539.6A  0.331
2003 Andreadis AA, Hazen SL, Comhair SAA, Erzurum SC. Oxidative and nitrosative events in asthma Free Radical Biology and Medicine. 35: 213-225. PMID 12885584 DOI: 10.1016/S0891-5849(03)00278-8  0.304
2003 Brennan ML, Hazen SL. Emerging role of myeloperoxidase and oxidant stress markers in cardiovascular risk assessment. Current Opinion in Lipidology. 14: 353-9. PMID 12865732 DOI: 10.1097/00041433-200308000-00003  0.344
2003 Shishehbor MH, Brennan ML, Aviles RJ, Fu X, Penn MS, Sprecher DL, Hazen SL. Statins promote potent systemic antioxidant effects through specific inflammatory pathways. Circulation. 108: 426-31. PMID 12860913 DOI: 10.1161/01.Cir.0000080895.05158.8B  0.354
2003 Gu X, Sun M, Gugiu B, Hazen S, Crabb JW, Salomon RG. Oxidatively truncated docosahexaenoate phospholipids: total synthesis, generation, and Peptide adduction chemistry. The Journal of Organic Chemistry. 68: 3749-61. PMID 12737551 DOI: 10.1021/Jo026721T  0.345
2003 Samoszuk M, Corwin M, Hazen SL. Effects of human mast cell tryptase and eosinophil granule proteins on the kinetics of blood clotting. American Journal of Hematology. 73: 18-25. PMID 12701115 DOI: 10.1002/Ajh.10323  0.306
2003 Fries DM, Paxinou E, Themistocleous M, Swanberg E, Griendling KK, Salvemini D, Slot JW, Heijnen HF, Hazen SL, Ischiropoulos H. Expression of inducible nitric-oxide synthase and intracellular protein tyrosine nitration in vascular smooth muscle cells: role of reactive oxygen species. The Journal of Biological Chemistry. 278: 22901-7. PMID 12690103 DOI: 10.1074/Jbc.M210806200  0.309
2003 Shishehbor MH, Aviles RJ, Brennan ML, Fu X, Goormastic M, Pearce GL, Gokce N, Keaney JF, Penn MS, Sprecher DL, Vita JA, Hazen SL. Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy. Jama. 289: 1675-80. PMID 12672736 DOI: 10.1001/Jama.289.13.1675  0.384
2003 Askari AT, Brennan ML, Zhou X, Drinko J, Morehead A, Thomas JD, Topol EJ, Hazen SL, Penn MS. Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction. The Journal of Experimental Medicine. 197: 615-24. PMID 12615902 DOI: 10.1084/Jem.20021426  0.304
2003 Shishehbor MH, Aviles RJ, Brennan M, Fu X, Penn MS, Sprecher DL, Gokce N, Keaney JF, Vita JA, Hazen SL. Levels of nitrotyrosine, an inflammatory marker generated by nitric oxide derived oxidants, is associated with risk of coronary artery disease Journal of the American College of Cardiology. 41: 303. DOI: 10.1016/S0735-1097(03)82420-8  0.339
2002 Zhang R, Brennan ML, Shen Z, MacPherson JC, Schmitt D, Molenda CE, Hazen SL. Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation. The Journal of Biological Chemistry. 277: 46116-22. PMID 12359714 DOI: 10.1074/Jbc.M209124200  0.383
2002 Hazen SL, Chisolm GM. Oxidized phosphatidylcholines: pattern recognition ligands for multiple pathways of the innate immune response. Proceedings of the National Academy of Sciences of the United States of America. 99: 12515-7. PMID 12271150 DOI: 10.1073/Pnas.212532799  0.386
2002 Podrez EA, Poliakov E, Shen Z, Zhang R, Deng Y, Sun M, Finton PJ, Shan L, Febbraio M, Hajjar DP, Silverstein RL, Hoff HF, Salomon RG, Hazen SL. A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. The Journal of Biological Chemistry. 277: 38517-23. PMID 12145296 DOI: 10.1074/Jbc.M205924200  0.315
2002 Podrez EA, Poliakov E, Shen Z, Zhang R, Deng Y, Sun M, Finton PJ, Shan L, Gugiu B, Fox PL, Hoff HF, Salomon RG, Hazen SL. Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36. The Journal of Biological Chemistry. 277: 38503-16. PMID 12105195 DOI: 10.1074/Jbc.M203318200  0.313
2002 Brennan ML, Wu W, Fu X, Shen Z, Song W, Frost H, Vadseth C, Narine L, Lenkiewicz E, Borchers MT, Lusis AJ, Lee JJ, Lee NA, Abu-Soud HM, Ischiropoulos H, ... Hazen SL, et al. A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species. The Journal of Biological Chemistry. 277: 17415-27. PMID 11877405 DOI: 10.1074/Jbc.M112400200  0.676
2002 Zhang R, Shen Z, Nauseef WM, Hazen SL. Defects in leukocyte-mediated initiation of lipid peroxidation in plasma as studied in myeloperoxidase-deficient subjects: systematic identification of multiple endogenous diffusible substrates for myeloperoxidase in plasma. Blood. 99: 1802-10. PMID 11861298 DOI: 10.1182/Blood.V99.5.1802  0.347
2001 Zhang R, Brennan ML, Fu X, Aviles RJ, Pearce GL, Penn MS, Topol EJ, Sprecher DL, Hazen SL. Association between myeloperoxidase levels and risk of coronary artery disease Journal of the American Medical Association. 286: 2136-2142. PMID 11694155 DOI: 10.1001/Jama.286.17.2136  0.33
2001 Denzler KL, Borchers MT, Crosby JR, Cieslewicz G, Hines EM, Justice JP, Cormier SA, Lindenberger KA, Song W, Wu W, Hazen SL, Gleich GJ, Lee JJ, Lee NA. Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation. Journal of Immunology (Baltimore, Md. : 1950). 167: 1672-82. PMID 11466391 DOI: 10.4049/jimmunol.167.3.1672  0.629
2001 Shen Z, Mitra SN, Wu W, Chen Y, Yang Y, Qin J, Hazen SL. Eosinophil peroxidase catalyzes bromination of free nucleosides and double-stranded DNA. Biochemistry. 40: 2041-51. PMID 11329271 DOI: 10.1021/Bi001961T  0.652
2001 MacPherson JC, Comhair SA, Erzurum SC, Klein DF, Lipscomb MF, Kavuru MS, Samoszuk MK, Hazen SL. Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species. Journal of Immunology (Baltimore, Md. : 1950). 166: 5763-72. PMID 11313420 DOI: 10.4049/Jimmunol.166.9.5763  0.335
2000 Hazen SL, Gaut JP, Crowley JR, Hsu FF, Heinecke JW. Elevated levels of protein-bound p-hydroxyphenylacetaldehyde, an amino-acid-derived aldehyde generated by myeloperoxidase, are present in human fatty streaks, intermediate lesions and advanced atherosclerotic lesions. The Biochemical Journal. 352: 693-9. PMID 11104675 DOI: 10.1042/0264-6021:3520693  0.389
2000 Podrez EA, Abu-Soud HM, Hazen SL. Myeloperoxidase-generated oxidants and atherosclerosis. Free Radical Biology & Medicine. 28: 1717-25. PMID 10946213 DOI: 10.1016/S0891-5849(00)00229-X  0.368
2000 Hazen SL. Oxidation and atherosclerosis Free Radical Biology and Medicine. 28: 1683-1684. PMID 10946209 DOI: 10.1016/S0891-5849(00)00355-5  0.308
2000 Salomon RG, Batyreva E, Kaur K, Sprecher DL, Schreiber MJ, Crabb JW, Penn MS, DiCorletoe AM, Hazen SL, Podrez EA. Isolevuglandin-protein adducts in humans: products of free radical-induced lipid oxidation through the isoprostane pathway. Biochimica Et Biophysica Acta. 1485: 225-35. PMID 10832102 DOI: 10.1016/S1388-1981(00)00038-X  0.401
2000 Shen Z, Wu W, Hazen SL. Activated leukocytes oxidatively damage DNA, RNA, and the nucleotide pool through halide-dependent formation of hydroxyl radical. Biochemistry. 39: 5474-82. PMID 10820020 DOI: 10.1021/Bi992809Y  0.656
2000 Wu W, Samoszuk MK, Comhair SA, Thomassen MJ, Farver CF, Dweik RA, Kavuru MS, Erzurum SC, Hazen SL. Eosinophils generate brominating oxidants in allergen-induced asthma. The Journal of Clinical Investigation. 105: 1455-63. PMID 10811853 DOI: 10.1172/Jci9702  0.675
2000 Podrez EA, Febbraio M, Sheibani N, Schmitt D, Silverstein RL, Hajjar DP, Cohen PA, Frazier WA, Hoff HF, Hazen SL. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. The Journal of Clinical Investigation. 105: 1095-108. PMID 10772654 DOI: 10.1172/Jci8574  0.324
2000 Heller JI, Crowley JR, Hazen SL, Salvay DM, Wagner P, Pennathur S, Heinecke JW. p-hydroxyphenylacetaldehyde, an aldehyde generated by myeloperoxidase, modifies phospholipid amino groups of low density lipoprotein in human atherosclerotic intima. The Journal of Biological Chemistry. 275: 9957-62. PMID 10744670 DOI: 10.1074/Jbc.275.14.9957  0.427
1999 Schmitt D, Shen Z, Zhang R, Colles SM, Wu W, Salomon RG, Chen Y, Chisolm GM, Hazen SL. Leukocytes utilize myeloperoxidase-generated nitrating intermediates as physiological catalysts for the generation of biologically active oxidized lipids and sterols in serum. Biochemistry. 38: 16904-15. PMID 10606525 DOI: 10.1021/Bi991623W  0.672
1999 Hazen SL, Zhang R, Shen Z, Wu W, Podrez EA, MacPherson JC, Schmitt D, Mitra SN, Mukhopadhyay C, Chen Y, Cohen PA, Hoff HF, Abu-Soud HM. Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes: pathways for monocyte-mediated protein nitration and lipid peroxidation In vivo. Circulation Research. 85: 950-8. PMID 10559142 DOI: 10.1161/01.Res.85.10.950  0.713
1999 Chisolm GM, Hazen SL, Fox PL, Cathcart MK. The oxidation of lipoproteins by monocytes-macrophages. Biochemical and biological mechanisms Journal of Biological Chemistry. 274: 25959-25962. PMID 10473535 DOI: 10.1074/Jbc.274.37.25959  0.334
1999 Wu W, Chen Y, Hazen SL. Eosinophil peroxidase nitrates protein tyrosyl residues. Implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disorders. The Journal of Biological Chemistry. 274: 25933-44. PMID 10464338 DOI: 10.1074/Jbc.274.36.25933  0.688
1999 Podrez EA, Schmitt D, Hoff HF, Hazen SL. Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro Journal of Clinical Investigation. 103: 1547-1560. PMID 10359564 DOI: 10.1172/Jci5549  0.397
1999 Whitman SC, Hazen SL, Miller DB, Hegele RA, Heinecke JW, Huff MW. Modification of type III VLDL, their remnants, and VLDL from ApoE-knockout mice by p-hydroxyphenylacetaldehyde, a product of myeloperoxidase activity, causes marked cholesteryl ester accumulation in macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 1238-49. PMID 10323775 DOI: 10.1161/01.Atv.19.5.1238  0.382
1999 Wu W, Chen Y, d'Avignon A, Hazen SL. 3-Bromotyrosine and 3,5-dibromotyrosine are major products of protein oxidation by eosinophil peroxidase: potential markers for eosinophil-dependent tissue injury in vivo. Biochemistry. 38: 3538-48. PMID 10090740 DOI: 10.1021/Bi982401L  0.684
1999 Heinecke JW, Hsu FF, Crowley JR, Hazen SL, Leeuwenburgh C, Mueller DM, Rasmussen JE, Turk J. Detecting oxidative modification of biomolecules with isotope dilution mass spectrometry: sensitive and quantitative assays for oxidized amino acids in proteins and tissues. Methods in Enzymology. 300: 124-44. PMID 9919517 DOI: 10.1016/S0076-6879(99)00121-4  0.331
1999 Hazen SL, Hsu FF, Gaut JP, Crowley JR, Heinecke JW. Modification of proteins and lipids by myeloperoxidase. Methods in Enzymology. 300: 88-105. PMID 9919513 DOI: 10.1016/S0076-6879(99)00117-2  0.398
1999 Hazen SL, Heller J, Hsu FF, d'Avignon A, Heinecke JW. Synthesis, isolation, and characterization of the adduct formed in the reaction of p-hydroxyphenylacetaldehyde with the amino headgroup of phosphatidylethanolamine and phosphatidylserine. Chemical Research in Toxicology. 12: 19-27. PMID 9894014 DOI: 10.1021/Tx980147S  0.341
1999 MacPherson JC, Wu W, Hazen SL. Eosinophils promote protein nitration in acute asthma Free Radical Biology and Medicine. 27: S123. DOI: 10.1016/S0891-5849(99)90919-X  0.628
1998 Hazen SL, Hsu FF, d'Avignon A, Heinecke JW. Human neutrophils employ myeloperoxidase to convert alpha-amino acids to a battery of reactive aldehydes: a pathway for aldehyde generation at sites of inflammation. Biochemistry. 37: 6864-73. PMID 9578573 DOI: 10.1021/Bi972449J  0.303
1997 Hazen SL, Crowley JR, Mueller DM, Heinecke JW. Mass spectrometric quantification of 3-chlorotyrosine in human tissues with attomole sensitivity: a sensitive and specific marker for myeloperoxidase-catalyzed chlorination at sites of inflammation. Free Radical Biology & Medicine. 23: 909-16. PMID 9378370 DOI: 10.1016/S0891-5849(97)00084-1  0.333
1997 Hazen SL, Gaut JP, Hsu FF, Crowley JR, d'Avignon A, Heinecke JW. p-Hydroxyphenylacetaldehyde, the major product of L-tyrosine oxidation by the myeloperoxidase-H2O2-chloride system of phagocytes, covalently modifies epsilon-amino groups of protein lysine residues. The Journal of Biological Chemistry. 272: 16990-8. PMID 9202012 DOI: 10.1074/Jbc.272.27.16990  0.326
1997 Hazen SL, Heinecke JW. 3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. The Journal of Clinical Investigation. 99: 2075-81. PMID 9151778 DOI: 10.1172/Jci119379  0.398
1997 Leeuwenburgh C, Hardy MM, Hazen SL, Wagner P, Oh-ishi S, Steinbrecher UP, Heinecke JW. Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima. The Journal of Biological Chemistry. 272: 1433-6. PMID 8999808 DOI: 10.1074/Jbc.272.3.1433  0.408
1996 Hazen SL, Hsu FF, Mueller DM, Crowley JR, Heinecke JW. Human neutrophils employ chlorine gas as an oxidant during phagocytosis. The Journal of Clinical Investigation. 98: 1283-9. PMID 8823292 DOI: 10.1172/Jci118914  0.328
1996 Hazen SL, Hsu FF, Duffin K, Heinecke JW. Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes converts low density lipoprotein cholesterol into a family of chlorinated sterols. The Journal of Biological Chemistry. 271: 23080-8. PMID 8798498 DOI: 10.1074/Jbc.271.38.23080  0.382
1996 Jacob JS, Cistola DP, Hsu FF, Muzaffar S, Mueller DM, Hazen SL, Heinecke JW. Human phagocytes employ the myeloperoxidase-hydrogen peroxide system to synthesize dityrosine, trityrosine, pulcherosine, and isodityrosine by a tyrosyl radical-dependent pathway. The Journal of Biological Chemistry. 271: 19950-6. PMID 8702710 DOI: 10.1074/Jbc.271.33.19950  0.353
1996 Hazen SL, Hsu FF, Heinecke JW. p-Hydroxyphenylacetaldehyde is the major product of L-tyrosine oxidation by activated human phagocytes. A chloride-dependent mechanism for the conversion of free amino acids into reactive aldehydes by myeloperoxidase. The Journal of Biological Chemistry. 271: 1861-7. PMID 8567631 DOI: 10.1074/Jbc.271.4.1861  0.326
1994 Hazen SL, Wolf MJ, Ford DA, Gross RW. The rapid and reversible association of phosphofructokinase with myocardial membranes during myocardial ischemia Febs Letters. 339: 213-216. PMID 8112458 DOI: 10.1016/0014-5793(94)80418-4  0.511
1993 Hazen SL, Hall CR, Ford DA, Gross RW. Isolation of a human myocardial cytosolic phospholipase A2 isoform. Fast atom bombardment mass spectroscopic and reverse-phase high pressure liquid chromatography identification of choline and ethanolamine glycerophospholipid substrates. The Journal of Clinical Investigation. 91: 2513-22. PMID 8514863 DOI: 10.1172/Jci116487  0.463
1993 Hazen SL, Gross RW. The specific association of a phosphofructokinase isoform with myocardial calcium-independent phospholipase A2. Implications for the coordinated regulation of phospholipolysis and glycolysis. The Journal of Biological Chemistry. 268: 9892-900. PMID 8486669  0.458
1993 Zupan LA, Weiss RH, Hazen SL, Parnas BL, Aston KW, Lennon PJ, Getman DP, Gross RW. Structural determinants of haloenol lactone-mediated suicide inhibition of canine myocardial calcium-independent phospholipase A2. Journal of Medicinal Chemistry. 36: 95-100. PMID 8421294 DOI: 10.1021/Jm00053A012  0.498
1992 Hazen SL, Gross RW. Identification and characterization of human myocardial phospholipase A2 from transplant recipients suffering from end-stage ischemic heart disease. Circulation Research. 70: 486-95. PMID 1537086 DOI: 10.1161/01.Res.70.3.486  0.475
1992 Han XL, Zupan LA, Hazen SL, Gross RW. Semisynthesis and purification of homogeneous plasmenylcholine molecular species. Analytical Biochemistry. 200: 119-24. PMID 1317681 DOI: 10.1016/0003-2697(92)90286-G  0.519
1991 Ford DA, Hazen SL, Saffitz JE, Gross RW. The rapid and reversible activation of a calcium-independent plasmalogen-selective phospholipase A2 during myocardial ischemia Journal of Clinical Investigation. 88: 331-335. PMID 2056126 DOI: 10.1172/Jci115296  0.514
1991 Hazen SL, Loeb LA, Gross RW. Purification and characterization of cytosolic phospholipase A2 activities from canine myocardium and sheep platelets. Methods in Enzymology. 197: 400-11. PMID 2051936 DOI: 10.1016/0076-6879(91)97166-V  0.498
1991 Hazen SL, Zupan LA, Weiss RH, Getman DP, Gross RW. Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2. The Journal of Biological Chemistry. 266: 7227-32. PMID 2016324  0.438
1991 Hazen SL, Ford DA, Gross RW. Activation of a membrane-associated phospholipase A2 during rabbit myocardial ischemia which is highly selective for plasmalogen substrate Journal of Biological Chemistry. 266: 5629-5633. PMID 2005103  0.464
1991 Hazen SL, Gross RW. ATP-dependent regulation of rabbit myocardial cytosolic calcium-independent phospholipase A2. The Journal of Biological Chemistry. 266: 14526-34. PMID 1860859  0.46
1991 Hazen SL, Gross RW. Human myocardial cytosolic Ca(2+)-independent phospholipase A2 is modulated by ATP. Concordant ATP-induced alterations in enzyme kinetics and mechanism-based inhibition. The Biochemical Journal. 280: 581-7. PMID 1764021 DOI: 10.1042/Bj2800581  0.528
1990 Hazen SL, Stuppy RJ, Gross RW. Purification and characterization of canine myocardial cytosolic phospholipase A2. A calcium-independent phospholipase with absolute f1-2 regiospecificity for diradyl glycerophospholipids. The Journal of Biological Chemistry. 265: 10622-30. PMID 2355013  0.463
Show low-probability matches.