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Reena Shakya, Ph.D. - Publications

Affiliations: 
2005 Columbia University, New York, NY 
Area:
Genetics, Molecular Biology
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Dauch C, Shim S, Cole MW, Pollock NC, Beer AJ, Ramroop J, Klee V, Allain DC, Shakya R, Knoblaugh SE, Kulewsky J, Toland AE. loss drives aggressive tumor phenotypes in cutaneous squamous cell carcinoma. American Journal of Cancer Research. 12: 1309-1322. PMID 35411237  0.301
2020 Purde V, Kudryashova E, Heisler DB, Shakya R, Kudryashov DS. Intein-mediated cytoplasmic reconstitution of a split toxin enables selective cell ablation in mixed populations and tumor xenografts. Proceedings of the National Academy of Sciences of the United States of America. PMID 32839344 DOI: 10.1073/Pnas.2006603117  0.384
2020 Park D, Bergin SM, Jones D, Ru P, Koivisto CS, Jeon YJ, Sizemore GM, Kladney RD, Hadjis A, Shakya R, Ludwig T. Ablation of the Brca1-Palb2 interaction phenocopies Fanconi anemia in mice. Cancer Research. PMID 32732220 DOI: 10.1158/0008-5472.Can-20-0486  0.349
2020 Choueiry F, Torok M, Shakya R, Agrawal K, Deems A, Benner B, Hinton A, Shaffer J, Blaser BW, Noonan AM, Williams TM, Dillhoff M, Conwell DL, Hart PA, Cruz-Monserrate Z, et al. CD200 promotes immunosuppression in the pancreatic tumor microenvironment. Journal For Immunotherapy of Cancer. 8. PMID 32581043 DOI: 10.1136/Jitc-2019-000189  0.319
2020 Geisler JA, Spehar JM, Steck SA, Bratasz A, Shakya R, Powell K, Sizemore GM. Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging. Journal of Visualized Experiments : Jove. PMID 32568247 DOI: 10.3791/61272  0.308
2019 Park D, Shakya R, Koivisto C, Pitarresi JR, Szabolcs M, Kladney R, Hadjis A, Mace TA, Ludwig T. Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains. Plos One. 14: e0226714. PMID 31877165 DOI: 10.1371/Journal.Pone.0226714  0.381
2019 Seligson ND, Stets CW, Demoret BW, Awasthi A, Grosenbacher N, Shakya R, Hays JL, Chen JL. Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma. Oncotarget. 10: 5671-5679. PMID 31620242 DOI: 10.18632/Oncotarget.27144  0.335
2019 Ware MB, McQuinn C, Mace TA, Bowers J, Shakya R, Farris B, Young G, Carson WE, Paulos CM, El-Rayes B, Lesinski GB. Abstract B59: IL-6 regulates CTLA4 expression on CD4+ T-cells and dual antibody blockade of IL-6 and CTLA4 leads to tumor regression in an orthotopic murine model of pancreatic ductal adenocarcinoma Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-B59  0.345
2018 Spaeth-Cook D, Burch M, Belton R, Demoret B, Grosenbacher N, David J, Stets C, Cohen D, Shakya R, Hays JL, Chen JL. Loss of TXNIP enhances peritoneal metastasis and can be abrogated by dual TORC1/2 inhibition. Oncotarget. 9: 35676-35686. PMID 30479697 DOI: 10.18632/Oncotarget.26281  0.361
2017 Farren MR, Hennessey RC, Shakya R, Elnaggar O, Young G, Kendra K, Landesman Y, Elloul S, Crochiere M, Klebanov B, Kashyap T, Burd CE, Lesinski GB. The exportin-1 inhibitor selinexor exerts superior anti-tumor activity when combined with T cell checkpoint inhibitors. Molecular Cancer Therapeutics. PMID 28148715 DOI: 10.1158/1535-7163.Mct-16-0498  0.344
2017 Sizemore ST, Sizemore GM, Shakya R, Amaya P, Hammer AM, Rice AH, Chalmers JJ, Ostrowski MC, Chakravarti A. Abstract 1354: The role of RALA in soft tissue sarcoma tumor growth and metastasis Cancer Research. 77: 1354-1354. DOI: 10.1158/1538-7445.Am2017-1354  0.3
2016 Guan X, LaPak KM, Hennessey RC, Yu CY, Shakya R, Zhang J, Burd CE. Stromal senescence by prolonged CDK4/6 inhibition potentiates tumor growth. Molecular Cancer Research : McR. PMID 28039358 DOI: 10.1158/1541-7786.Mcr-16-0319  0.413
2016 Pitarresi JR, Liu X, Sharma SM, Cuitiño MC, Kladney RD, Mace TA, Donohue S, Nayak SG, Qu C, Lee J, Woelke SA, Trela S, LaPak K, Yu L, McElroy J, ... ... Shakya R, et al. Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia. Neoplasia (New York, N.Y.). 18: 541-52. PMID 27659014 DOI: 10.1016/J.Neo.2016.07.006  0.453
2016 Liu X, Pitarresi JR, Cuitiño MC, Kladney RD, Woelke SA, Sizemore GM, Nayak SG, Egriboz O, Schweickert PG, Yu L, Trela S, Schilling DJ, Halloran SK, Li M, Dutta S, ... ... Shakya R, et al. Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. Genes & Development. PMID 27633013 DOI: 10.1101/Gad.283499.116  0.453
2016 Reczek CR, Shakya R, Miteva Y, Szabolcs M, Ludwig T, Baer R. The DNA resection protein CtIP promotes mammary tumorigenesis. Oncotarget. PMID 27058754 DOI: 10.18632/Oncotarget.8605  0.344
2016 Farren MR, Shakya R, Hennessey R, Mace T, Yang J, Elnaggar O, Young G, Landesman Y, Carlson R, Elloul S, Crochiere M, Burd C, Lesinski GB. Abstract 2319: Selinexor, a selective inhibitor of nuclear export (SINE), enhances the in vivo efficacy of checkpoint blockade with antibodies targeting CTLA4 or PD-1/PD-L1 in melanoma Cancer Research. 76: 2319-2319. DOI: 10.1158/1538-7445.Am2016-2319  0.339
2016 Walker CJ, Rush C, Dama P, Stein M, Shakya R, O’Hern M, Mutch DG, Cohn DE, Goodfellow PJ. Abstract 2002: MAX mutations in endometrial cancer are associated with poor patient outcome, altered E-box binding, and increased tumor vascularity Cancer Research. 76: 2002-2002. DOI: 10.1158/1538-7445.Am2016-2002  0.373
2015 Mace TA, Shakya R, Elnaggar O, Wilson K, Komar HM, Yang J, Pitarresi JR, Young GS, Ostrowski MC, Ludwig T, Bekaii-Saab T, Bloomston M, Lesinski GB. Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer. Oncotarget. PMID 26575024 DOI: 10.18632/Oncotarget.6332  0.43
2015 Mace T, Shakya R, Pitarresi J, Loftus S, Swanson B, Young G, Zhong X, Zimmers T, Ostrowski M, Ludwig T, Bloomston M, Bekaii-Saab T, Lesinski G. Anti-IL-6 and PD-L1 antibody combination therapy reduces tumor progression in murine models of pancreatic cancer Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-P366  0.336
2015 Farren MR, Shakya R, Hennessey R, Mace T, Yang J, Elnaggar O, Young G, Landesman Y, Carlson R, Elloul S, Crochiere M, Burd C, Lesinski G. Selinexor, a selective inhibitor of nuclear export (SINE), shows enhanced activity in combination with PD-1/PD-L1 blockade in syngeneic murine models of colon cancer and melanoma Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-P355  0.314
2014 Sonabend AM, Bansal M, Guarnieri P, Lei L, Amendolara B, Soderquist C, Leung R, Yun J, Kennedy B, Sisti J, Bruce S, Bruce R, Shakya R, Ludwig T, Rosenfeld S, et al. The transcriptional regulatory network of proneural glioma determines the genetic alterations selected during tumor progression. Cancer Research. 74: 1440-51. PMID 24390738 DOI: 10.1158/0008-5472.Can-13-2150  0.347
2014 Lowery MA, Lee A, Tobias E, Sung P, Bhanot U, Shakya R, Ludwig T, O'Reilly EM, Jasin M, Moynahan ME. Evaluation of PARP inhibition as a platinum sparing strategy in Brca2-deficient pancreatic tumors. Journal of Clinical Oncology. 32: e15237-e15237. DOI: 10.1200/Jco.2014.32.15_Suppl.E15237  0.321
2014 Mace T, Shakya R, Swanson B, Ludwig T, Elnaggar O, Komar H, Yang J, Young G, Frankel W, Muscarella P, Bekaii-Saab T, Bloomston M, Lesinski G. BMS-911543 inhibits viability of tumor and stromal cells and limits disease progression in genetically engineered mice with pancreatic cancer Journal For Immunotherapy of Cancer. 2. DOI: 10.1186/2051-1426-2-S3-P186  0.433
2013 Shakya R, Gonda T, Quante M, Salas M, Kim S, Brooks J, Hirsch S, Davies J, Cullo A, Olive K, Wang TC, Szabolcs M, Tycko B, Ludwig T. Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma. Cancer Research. 73: 885-96. PMID 23204224 DOI: 10.1158/0008-5472.Can-12-1880  0.408
2013 Mace TA, Pitaressi J, Shakya R, Frankel W, Eubank T, Bekaii-Saab T, Bloomston M, Phelps M, Ludwig T, Ostrowski M, Lesinski GB. Genetically engineered murine pancreatic cancer models approximate immunophenotypic properties of human patients Journal For Immunotherapy of Cancer. 1. DOI: 10.1186/2051-1426-1-S1-P163  0.413
2013 Agarwal M, Nitta R, Dovat S, Li G, Arita H, Narita Y, Fukushima S, Tateishi K, Matsushita Y, Yoshida A, Miyakita Y, Ohno M, Collins VP, Kawahara N, Shibui S, ... ... Shakya R, et al. CELL BIOLOGY AND SIGNALING Neuro-Oncology. 15: iii12-iii31. DOI: 10.1093/Neuonc/Not174  0.41
2011 Shakya R, Reid LJ, Reczek CR, Cole F, Egli D, Lin CS, deRooij DG, Hirsch S, Ravi K, Hicks JB, Szabolcs M, Jasin M, Baer R, Ludwig T. BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science (New York, N.Y.). 334: 525-8. PMID 22034435 DOI: 10.1126/Science.1209909  0.355
2009 Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M, Mendelsohn C, Costantini F. Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. Developmental Cell. 17: 199-209. PMID 19686681 DOI: 10.1016/J.Devcel.2009.07.013  0.666
2008 Reid LJ, Shakya R, Modi AP, Lokshin M, Cheng JT, Jasin M, Baer R, Ludwig T. E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks. Proceedings of the National Academy of Sciences of the United States of America. 105: 20876-81. PMID 19088202 DOI: 10.1073/Pnas.0811203106  0.371
2008 Shakya R, Szabolcs M, McCarthy E, Ospina E, Basso K, Nandula S, Murty V, Baer R, Ludwig T. The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression. Proceedings of the National Academy of Sciences of the United States of America. 105: 7040-5. PMID 18443292 DOI: 10.1073/Pnas.0711032105  0.366
2006 Basson MA, Watson-Johnson J, Shakya R, Akbulut S, Hyink D, Costantini FD, Wilson PD, Mason IJ, Licht JD. Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1. Developmental Biology. 299: 466-77. PMID 17022962 DOI: 10.1016/J.Ydbio.2006.08.051  0.623
2006 Costantini F, Shakya R. GDNF/Ret signaling and the development of the kidney. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 28: 117-27. PMID 16435290 DOI: 10.1002/Bies.20357  0.631
2005 Shakya R, Jho EH, Kotka P, Wu Z, Kholodilov N, Burke R, D'Agati V, Costantini F. The role of GDNF in patterning the excretory system. Developmental Biology. 283: 70-84. PMID 15890330 DOI: 10.1016/J.Ydbio.2005.04.008  0.597
2005 Basson MA, Akbulut S, Watson-Johnson J, Simon R, Carroll TJ, Shakya R, Gross I, Martin GR, Lufkin T, McMahon AP, Wilson PD, Costantini FD, Mason IJ, Licht JD. Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Developmental Cell. 8: 229-39. PMID 15691764 DOI: 10.1016/J.Devcel.2004.12.004  0.595
2005 Shakya R, Watanabe T, Costantini F. The role of GDNF/Ret signaling in ureteric bud cell fate and branching morphogenesis. Developmental Cell. 8: 65-74. PMID 15621530 DOI: 10.1016/J.Devcel.2004.11.008  0.676
2001 Hsu W, Shakya R, Costantini F. Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice. The Journal of Cell Biology. 155: 1055-64. PMID 11739413 DOI: 10.1083/Jcb.200107066  0.595
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