| Year |
Citation |
Score |
| 2023 |
Maccarrone M, Di Marzo V, Gertsch J, Grether U, Howlett AC, Hua T, Makriyannis A, Piomelli D, Ueda N, van der Stelt M. . Pharmacological Reviews. PMID 37164640 DOI: 10.1124/pharmrev.122.000600 |
0.338 |
|
| 2023 |
Breivogel CS, Brenseke BM, Eldeeb K, Nichols K, Jonas A, Mistry AH, Barbalato L, Luibil N, Howlett AC, Leone-Kabler S, Hilgers RPH, Pulgar VM. Effects of Δ-Tetrahydrocannabinol and the Aminoalkylindole K2/Spice Constituent JWH-073 on Cardiac Tissue and Mesenteric Vascular Reactivity. Cannabis and Cannabinoid Research. PMID 37010379 DOI: 10.1089/can.2022.0325 |
0.284 |
|
| 2023 |
Kline T, Xu C, Kreitzer FR, Hurst DP, Eldeeb KM, Wager-Miller J, Olivas K, Hepburn SA, Huffman JW, Mackie K, Howlett AC, Reggio P, Stella N. Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB and CB receptors. European Journal of Medicinal Chemistry. 249: 115123. PMID 36708677 DOI: 10.1016/j.ejmech.2023.115123 |
0.461 |
|
| 2022 |
Wang S, Neel AI, Adams KL, Sun H, Jones SR, Howlett AC, Chen R. Atorvastatin differentially regulates the interactions of cocaine and amphetamine with dopamine transporters. Neuropharmacology. 225: 109387. PMID 36567004 DOI: 10.1016/j.neuropharm.2022.109387 |
0.303 |
|
| 2022 |
Pulgar VM, Howlett AC, Eldeeb K. WIN55212-2 Modulates Intracellular Calcium via CB Receptor-Dependent and Independent Mechanisms in Neuroblastoma Cells. Cells. 11. PMID 36230909 DOI: 10.3390/cells11192947 |
0.356 |
|
| 2021 |
Howlett AC, Thomas BF, Huffman JW. The Spicy Story of Cannabimimetic Indoles. Molecules (Basel, Switzerland). 26. PMID 34684770 DOI: 10.3390/molecules26206190 |
0.448 |
|
| 2021 |
Booth WT, Clodfelter JE, Leone-Kabler S, Hughes EK, Eldeeb K, Howlett AC, Lowther WT. Cannabinoid receptor interacting protein 1a (CRIP1a) interacts with myristoylated Gα-N-terminus via a unique gapped β-barrel structure. The Journal of Biological Chemistry. 101099. PMID 34418434 DOI: 10.1016/j.jbc.2021.101099 |
0.383 |
|
| 2021 |
Kozakiewicz ML, Grotegut CA, Howlett AC. Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review. Frontiers in Endocrinology. 12: 699951. PMID 34220722 DOI: 10.3389/fendo.2021.699951 |
0.26 |
|
| 2021 |
Kozakiewicz ML, Zhang J, Leone-Kabler S, Yamaleyeva LM, McDonald AG, Brost BC, Howlett AC. Differential Expression of CB Cannabinoid Receptor and Cannabinoid Receptor Interacting Protein 1a in Labor. Cannabis and Cannabinoid Research. PMID 33998898 DOI: 10.1089/can.2020.0107 |
0.396 |
|
| 2021 |
Keegan BM, Dreitzler AL, Sexton T, Beveridge TJR, Smith HR, Miller MD, Blough BE, Porrino LJ, Childers SR, Howlett AC. Chronic phenmetrazine treatment promotes D dopaminergic and α2-adrenergic receptor desensitization and alters phosphorylation of signaling proteins and local cerebral glucose metabolism in the rat brain. Brain Research. 147387. PMID 33631209 DOI: 10.1016/j.brainres.2021.147387 |
0.371 |
|
| 2020 |
Oliver EE, Hughes EK, Puckett MK, Chen R, Lowther WT, Howlett AC. Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease. Biomolecules. 10. PMID 33261012 DOI: 10.3390/biom10121609 |
0.455 |
|
| 2020 |
Lyons EL, Leone-Kabler S, Kovach AL, Thomas BF, Howlett AC. Cannabinoid receptor subtype influence on neuritogenesis in human SH-SY5Y cells. Molecular and Cellular Neurosciences. 103566. PMID 33049367 DOI: 10.1016/j.mcn.2020.103566 |
0.45 |
|
| 2020 |
Burgos-Aguilar C, Ferris MJ, Sexton LL, Sun H, Xiao R, Chen R, Childers SR, Howlett AC. Metabotropic glutamate 2,3 receptor stimulation desensitizes agonist activation of G-protein signaling and alters transcription regulators in mesocorticolimbic brain regions. Synapse (New York, N.Y.). e22190. PMID 33025628 DOI: 10.1002/syn.22190 |
0.38 |
|
| 2020 |
Dalton GD, Carney ST, Marshburn JD, Norford DC, Howlett AC. CB Cannabinoid Receptors Stimulate Gβγ-GRK2-Mediated FAK Phosphorylation at Tyrosine 925 to Regulate ERK Activation Involving Neuronal Focal Adhesions. Frontiers in Cellular Neuroscience. 14: 176. PMID 32655375 DOI: 10.3389/Fncel.2020.00176 |
0.461 |
|
| 2020 |
Schurman LD, Lu D, Kendall DA, Howlett AC, Lichtman AH. Molecular Mechanism and Cannabinoid Pharmacology. Handbook of Experimental Pharmacology. PMID 32236882 DOI: 10.1007/164_2019_298 |
0.542 |
|
| 2020 |
Eldeeb K, Wittmann TG, Leone-Kabler S, Howlett AC. The CB1 cannabinoid receptor‐mediated inhibition of cAMP accumulation in neuroblastoma cells: role of different Gi/o protein subtypes The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04298 |
0.421 |
|
| 2020 |
Kozakiewicz ML, Zhang J, Leone-Kabler S, Yamaleyeva LM, Brost BC, Howlett AC. 902: CB1 cannabinoid receptor and cannabinoid receptor interacting protein in human myometrium and placenta during labor American Journal of Obstetrics and Gynecology. 222: S560-S561. DOI: 10.1016/J.Ajog.2019.11.913 |
0.551 |
|
| 2019 |
Eldeeb K, Ganjiwale AD, Chandrashekaran IR, Padgett LW, Burgess J, Howlett AC, Cowsik SM. CB1 cannabinoid receptor-phosphorylated fourth intracellular loop structure-function relationships. Peptide Science (Hoboken, N.J.). 111. PMID 32411924 DOI: 10.1002/Pep2.24104 |
0.439 |
|
| 2019 |
Singh P, Ganjiwale AD, Howlett AC, Cowsik SM. Molecular interaction between distal C-terminal domain of the CB1 cannabinoid receptor and Cannabinoid Receptor Interacting Proteins (CRIP1a/CRIP1b). Journal of Chemical Information and Modeling. PMID 31769975 DOI: 10.1021/Acs.Jcim.9B00948 |
0.411 |
|
| 2019 |
Booth WT, Walker NB, Lowther WT, Howlett AC. Cannabinoid Receptor Interacting Protein 1a (CRIP1a): Function and Structure. Molecules (Basel, Switzerland). 24. PMID 31614728 DOI: 10.3390/Molecules24203672 |
0.568 |
|
| 2019 |
Fatima H, Howlett AC, Whitlow CT. Reward, control & decision-making in cannabis use disorder: insights from functional MRI. The British Journal of Radiology. 20190165. PMID 31364398 DOI: 10.1259/Bjr.20190165 |
0.338 |
|
| 2019 |
Horton KA, Goonawardena AV, Sesay J, Howlett AC, Hampson RE. Systemic Blockade of the CB Receptor Augments Hippocampal Gene Expression Involved in Synaptic Plasticity but Perturbs Hippocampus-Dependent Learning Task. Cannabis and Cannabinoid Research. 4: 33-41. PMID 31032421 DOI: 10.1089/can.2018.0061 |
0.322 |
|
| 2019 |
Abood M, Alexander SP, Barth F, Bonner TI, Bradshaw H, Cabral G, Casellas P, Cravatt BF, Devane WA, Di Marzo V, Elphick MR, Felder CC, Greasley P, Herkenham M, Howlett AC, et al. Cannabinoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f13/2019.4 |
0.482 |
|
| 2018 |
Ilyasov AA, Milligan CE, Pharr EP, Howlett AC. The Endocannabinoid System and Oligodendrocytes in Health and Disease. Frontiers in Neuroscience. 12: 733. PMID 30416422 DOI: 10.3389/Fnins.2018.00733 |
0.461 |
|
| 2017 |
Singh P, Ganjiwale A, Howlett AC, Cowsik SM. In silico interaction analysis of cannabinoid receptor interacting protein 1b (CRIP1b) - CB1 cannabinoid receptor. Journal of Molecular Graphics & Modelling. 77: 311-321. PMID 28918320 DOI: 10.1016/J.Jmgm.2017.09.006 |
0.541 |
|
| 2017 |
Howlett AC, Abood ME. CB1 and CB2 Receptor Pharmacology. Advances in Pharmacology (San Diego, Calif.). 80: 169-206. PMID 28826534 DOI: 10.1016/Bs.Apha.2017.03.007 |
0.579 |
|
| 2017 |
Eldeeb K, Leone-Kabler S, Howlett AC. Mouse Neuroblastoma CB1 Cannabinoid Receptor-Stimulated [(35)S]GTPɣS Binding: Total and Antibody-Targeted Gα Protein-Specific Scintillation Proximity Assays. Methods in Enzymology. 593: 1-21. PMID 28750799 DOI: 10.1016/Bs.Mie.2017.06.028 |
0.524 |
|
| 2017 |
Singh P, Ganjiwale A, Howlett AC, Cowsik SM. Molecular Interactions of Cannabinoid Receptor Interacting Protein 1 A and B with Cannabinoid Receptor 1 Biophysical Journal. 112: 54a. DOI: 10.1016/J.Bpj.2016.11.331 |
0.457 |
|
| 2016 |
Gwathmey TM, Tallant EA, Howlett AC, Diz DI. Programs to Recruit and Retain a More Diverse Workforce in Biomedical Sciences Research. Journal of Best Practices in Health Professions Diversity : Research, Education and Policy. 9: 1188-1194. PMID 28868526 |
0.19 |
|
| 2016 |
Lane M, Bell R, Latham-Sadler B, Bradley C, Foxworth J, Smith N, Millar AL, Hairston KG, Roper B, Howlett A. Translational Research Training at Various Levels of Professional Experience to Address Health Disparities. Journal of Best Practices in Health Professions Diversity : Research, Education and Policy. 9: 1178-1187. PMID 28804792 |
0.179 |
|
| 2016 |
Budygin EA, Oleson EB, Lee YB, Blume LC, Bruno MJ, Howlett AC, Thompson AC, Bass CE. Acute Depletion of D2 Receptors from the Rat Substantia Nigra Alters Dopamine Kinetics in the Dorsal Striatum and Drug Responsivity. Frontiers in Behavioral Neuroscience. 10: 248. PMID 28154530 DOI: 10.3389/Fnbeh.2016.00248 |
0.696 |
|
| 2016 |
Blume LC, Patten T, Eldeeb K, Leone-Kabler S, Ilyasov AA, Keegan BM, O'Neal JE, Bass CE, Hantgan RR, Lowther WT, Selley DE, Howlett AC. Cannabinoid Receptor Interacting Protein (CRIP) 1a competition with β-arrestin for CB1 receptor binding sites. Molecular Pharmacology. PMID 27895162 DOI: 10.1124/Mol.116.104638 |
0.661 |
|
| 2016 |
Luessen DJ, Hinshaw TP, Sun H, Howlett AC, Marrs G, McCool BA, Chen R. RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells. Neuropharmacology. PMID 27528587 DOI: 10.1016/J.Neuropharm.2016.08.009 |
0.493 |
|
| 2016 |
Blume LC, Leone-Kabler S, Luessen DJ, Marrs GS, Lyons E, Bass CE, Chen R, Selley DE, Howlett AC. Cannabinoid Receptor Interacting Protein (CRIP1a) suppresses agonist-driven CB1 receptor internalization, and regulates receptor replenishment in an agonist-biased manner. Journal of Neurochemistry. PMID 27513693 DOI: 10.1111/Jnc.13767 |
0.731 |
|
| 2016 |
Schaich CL, Grabenauer M, Thomas BF, Shaltout HA, Gallagher PE, Howlett AC, Diz DI. Medullary Endocannabinoids Contribute to the Differential Resting Baroreflex Sensitivity in Rats with Altered Brain Renin-Angiotensin System Expression. Frontiers in Physiology. 7: 207. PMID 27375489 DOI: 10.3389/Fphys.2016.00207 |
0.369 |
|
| 2016 |
Eldeeb K, Leone-Kabler S, Howlett AC. CB1 cannabinoid receptor-mediated increases in cyclic AMP accumulation are correlated with reduced Gi/o function. Journal of Basic and Clinical Physiology and Pharmacology. 27: 311-22. PMID 27089415 DOI: 10.1515/Jbcpp-2015-0096 |
0.525 |
|
| 2016 |
Ganjiwale A, Eldeeb K, Chandrashekar I, Cowsik S, Howlett A. Phosphorylation of CB1Cannabinoid Receptor Fourth Intracellular Loop Peptides: Effects on Structure and Function Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Mz2/Pdb |
0.458 |
|
| 2015 |
Sesay JS, Gyapong RN, Najafi LT, Kabler SL, Diz DI, Howlett AC, Awumey EM. Gαi/o-dependent Ca(2+) mobilization and Gαq-dependent PKCα regulation of Ca(2+)-sensing receptor-mediated responses in N18TG2 neuroblastoma cells. Neurochemistry International. 90: 142-51. PMID 26190181 DOI: 10.1016/J.Neuint.2015.07.008 |
0.367 |
|
| 2015 |
Conner-Kerr T, Malpass G, Steele A, Howlett A. Effects of 35 kHz, low-frequency ultrasound application in vitro on human fibroblast morphology and migration patterns. Ostomy/Wound Management. 61: 34-41. PMID 25751849 |
0.23 |
|
| 2015 |
Keegan BM, Beveridge TJ, Pezor JJ, Xiao R, Sexton T, Childers SR, Howlett AC. Chronic baclofen desensitizes GABAB-mediated G-protein activation and stimulates phosphorylation of kinases in mesocorticolimbic rat brain. Neuropharmacology. 95: 492-502. PMID 25724082 DOI: 10.1016/J.Neuropharm.2015.02.021 |
0.483 |
|
| 2015 |
Smith TH, Blume LC, Straiker A, Cox JO, David BG, McVoy JR, Sayers KW, Poklis JL, Abdullah RA, Egertová M, Chen CK, Mackie K, Elphick MR, Howlett AC, Selley DE. Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation. Molecular Pharmacology. 87: 747-65. PMID 25657338 DOI: 10.1124/Mol.114.096495 |
0.571 |
|
| 2015 |
Schaich CL, Shaltout HA, Grabenauer M, Thomas BF, Gallagher PE, Howlett AC, Diz DI. Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity. Journal of Cardiovascular Pharmacology. 65: 473-9. PMID 25636077 DOI: 10.1097/Fjc.0000000000000216 |
0.43 |
|
| 2015 |
Blume LC, Eldeeb K, Bass CE, Selley DE, Howlett AC. Cannabinoid receptor interacting protein (CRIP1a) attenuates CB1R signaling in neuronal cells. Cellular Signalling. 27: 716-26. PMID 25446256 DOI: 10.1016/J.Cellsig.2014.11.006 |
0.734 |
|
| 2015 |
Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB. [16-OR] Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. 5: 8. DOI: 10.1016/J.Preghy.2014.10.020 |
0.358 |
|
| 2014 |
Mechoulam R, Hanuš LO, Pertwee R, Howlett AC. Early phytocannabinoid chemistry to endocannabinoids and beyond Nature Reviews Neuroscience. 15: 757-764. PMID 25315390 DOI: 10.1038/Nrn3811 |
0.418 |
|
| 2014 |
Schaich CL, Shaltout HA, Brosnihan KB, Howlett AC, Diz DI. Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 rats. Physiological Reports. 2. PMID 25168868 DOI: 10.14814/Phy2.12108 |
0.458 |
|
| 2014 |
Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB. Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. Hypertension. 64: 619-25. PMID 24935942 DOI: 10.1161/Hypertensionaha.114.03633 |
0.399 |
|
| 2014 |
Malpass GE, Arimilli S, Prasad GL, Howlett AC. Regulation of gene expression by tobacco product preparations in cultured human dermal fibroblasts. Toxicology and Applied Pharmacology. 279: 211-9. PMID 24927667 DOI: 10.1016/J.Taap.2014.06.001 |
0.351 |
|
| 2014 |
Calipari ES, Sun H, Eldeeb K, Luessen DJ, Feng X, Howlett AC, Jones SR, Chen R. Amphetamine self-administration attenuates dopamine D2 autoreceptor function. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1833-42. PMID 24513972 DOI: 10.1038/Npp.2014.30 |
0.485 |
|
| 2014 |
Tracy CM, Gray AJ, Cuéllar J, Shaw TS, Howlett AC, Taylor RM, Prince JT, Ahn NG, Valpuesta JM, Willardson BM. Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate β-tubulin folding. The Journal of Biological Chemistry. 289: 4490-502. PMID 24375412 DOI: 10.1074/Jbc.M113.542159 |
0.287 |
|
| 2014 |
Campeau L, Füllhase C, Sawada N, Gratzke C, Hedlund P, Howlett AC, Andersson KE. Characterization of bladder function in a cannabinoid receptor type 2 knockout mouse in vivo and in vitro. Neurourology and Urodynamics. 33: 566-70. PMID 23908133 DOI: 10.1002/Nau.22454 |
0.443 |
|
| 2014 |
Rai P, Howlett A, Cowsik SM. Structural Analysis of CRIP1a by in Silico Approaches Biophysical Journal. 106: 208a. DOI: 10.1016/J.Bpj.2013.11.1219 |
0.469 |
|
| 2014 |
Blume LC, Eldeeb KM, Howlett AC. Cannabinoid receptor intracellular signalling: The long journey from binding sites to biological effects Cannabinoids. 17-52. DOI: 10.1002/9781118451281.ch2 |
0.482 |
|
| 2013 |
Thomas G, Betters JL, Lord CC, Brown AL, Marshall S, Ferguson D, Sawyer J, Davis MA, Melchior JT, Blume LC, Howlett AC, Ivanova PT, Milne SB, Myers DS, Mrak I, et al. The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome. Cell Reports. 5: 508-20. PMID 24095738 DOI: 10.1016/J.Celrep.2013.08.047 |
0.353 |
|
| 2013 |
Malpass GE, Arimilli S, Prasad GL, Howlett AC. Complete artificial saliva alters expression of proinflammatory cytokines in human dermal fibroblasts. Toxicological Sciences : An Official Journal of the Society of Toxicology. 134: 18-25. PMID 23629517 DOI: 10.1093/Toxsci/Kft103 |
0.343 |
|
| 2013 |
Dalton GD, Peterson LJ, Howlett AC. CB₁ cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells. Cellular Signalling. 25: 1665-77. PMID 23571270 DOI: 10.1016/J.Cellsig.2013.03.020 |
0.486 |
|
| 2013 |
McQuail JA, Davis KN, Miller F, Hampson RE, Deadwyler SA, Howlett AC, Nicolle MM. Hippocampal Gαq/â‚â‚ but not Gαo-coupled receptors are altered in aging. Neuropharmacology. 70: 63-73. PMID 23347951 DOI: 10.1016/J.Neuropharm.2013.01.009 |
0.397 |
|
| 2013 |
Blume LC, Bass CE, Childers SR, Dalton GD, Roberts DC, Richardson JM, Xiao R, Selley DE, Howlett AC. Striatal CB1 and D2 receptors regulate expression of each other, CRIP1A and δ opioid systems. Journal of Neurochemistry. 124: 808-20. PMID 23286559 DOI: 10.1111/Jnc.12139 |
0.716 |
|
| 2013 |
Campeau L, Füllhase C, Hedlund P, Howlett A, Andersson K. 544 ROLE OF CANNABINOID AND TRPV1 RECEPTORS IN THE SPINAL MECHANISMS OF MICTURITION IN THE NORMAL RAT Journal of Urology. 189. DOI: 10.1016/J.Juro.2013.02.1939 |
0.46 |
|
| 2013 |
Campeau L, Füllhase C, Sawada N, Gratzke C, Hedlund P, Howlett A, Andersson K. 288 INVOLVEMENT OF CANNABINOID RECEPTOR TYPE 2 IN MICTURITION IN MICE Journal of Urology. 189. DOI: 10.1016/J.Juro.2013.02.1672 |
0.468 |
|
| 2013 |
Ganjiwale AD, Howlett AC, Cowsik SM. Conformational Characterization of Phosphorylated Analogs of a Peptide Mimetic of the Fourth Cytoplasmic Loop of CB1Cannabinoid Receptor Biophysical Journal. 104: 555a. DOI: 10.1016/j.bpj.2012.11.3077 |
0.371 |
|
| 2012 |
Evans DW, Scott AT, Teasdall RD, Smith BP, Howlett A, Connor-Kerr T, Sparks JL. Mechanical properties of lower limb dermis following static and cyclic compression. Biomedical Sciences Instrumentation. 48: 104-11. PMID 22846271 |
0.204 |
|
| 2012 |
Oddi S, Dainese E, Sandiford S, Fezza F, Lanuti M, Chiurchiù V, Totaro A, Catanzaro G, Barcaroli D, De Laurenzi V, Centonze D, Mukhopadhyay S, Selent J, Howlett AC, Maccarrone M. Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling. British Journal of Pharmacology. 165: 2635-51. PMID 21895628 DOI: 10.1111/J.1476-5381.2011.01658.X |
0.735 |
|
| 2012 |
Dalton GD, Howlett AC. Cannabinoid CB1 receptors transactivate multiple receptor tyrosine kinases and regulate serine/threonine kinases to activate ERK in neuronal cells. British Journal of Pharmacology. 165: 2497-511. PMID 21518335 DOI: 10.1111/J.1476-5381.2011.01455.X |
0.499 |
|
| 2011 |
Howlett AC, Reggio PH, Childers SR, Hampson RE, Ulloa NM, Deutsch DG. Endocannabinoid tone versus constitutive activity of cannabinoid receptors. British Journal of Pharmacology. 163: 1329-43. PMID 21545414 DOI: 10.1111/J.1476-5381.2011.01364.X |
0.578 |
|
| 2010 |
Pertwee RG, Howlett AC, Abood ME, Alexander SP, Di Marzo V, Elphick MR, Greasley PJ, Hansen HS, Kunos G, Mackie K, Mechoulam R, Ross RA. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CBâ‚ and CBâ‚‚. Pharmacological Reviews. 62: 588-631. PMID 21079038 DOI: 10.1124/Pr.110.003004 |
0.55 |
|
| 2010 |
Skelly MJ, Guy EG, Howlett AC, Pratt WE. CB1 receptors modulate the intake of a sweetened-fat diet in response to μ-opioid receptor stimulation of the nucleus accumbens. Pharmacology, Biochemistry, and Behavior. 97: 144-51. PMID 20562021 DOI: 10.1016/J.Pbb.2010.05.024 |
0.498 |
|
| 2010 |
Howlett AC, Blume LC, Dalton GD. CB(1) cannabinoid receptors and their associated proteins. Current Medicinal Chemistry. 17: 1382-93. PMID 20166926 DOI: 10.2174/092986710790980023 |
0.568 |
|
| 2009 |
Dalton GD, Bass CE, Van Horn CG, Howlett AC. Signal transduction via cannabinoid receptors. Cns & Neurological Disorders Drug Targets. 8: 422-31. PMID 19839935 DOI: 10.2174/187152709789824615 |
0.769 |
|
| 2009 |
Howlett AC, Gray AJ, Hunter JM, Willardson BM. Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. The Journal of Biological Chemistry. 284: 16386-99. PMID 19376773 DOI: 10.1074/Jbc.M900800200 |
0.314 |
|
| 2009 |
Carney ST, Lloyd ML, MacKinnon SE, Newton DC, Jones JD, Howlett AC, Norford DC. Cannabinoid regulation of nitric oxide synthase I (nNOS) in neuronal cells. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 338-49. PMID 19365734 DOI: 10.1007/S11481-009-9153-7 |
0.512 |
|
| 2008 |
Gerald TM, Howlett AC, Ward GR, Ho C, Franklin SO. Gene expression of opioid and dopamine systems in mouse striatum: effects of CB1 receptors, age and sex. Psychopharmacology. 198: 497-508. PMID 18438728 DOI: 10.1007/S00213-008-1141-8 |
0.503 |
|
| 2008 |
Padgett LW, Howlett AC, Shim JY. Binding mode prediction of conformationally restricted anandamide analogs within the CB1 receptor. Journal of Molecular Signaling. 3: 5. PMID 18302793 DOI: 10.1186/1750-2187-3-5 |
0.549 |
|
| 2008 |
Jones JD, Carney ST, Vrana KE, Norford DC, Howlett AC. Cannabinoid receptor-mediated translocation of NO-sensitive guanylyl cyclase and production of cyclic GMP in neuronal cells. Neuropharmacology. 54: 23-30. PMID 17707868 DOI: 10.1016/J.Neuropharm.2007.06.027 |
0.538 |
|
| 2007 |
Niehaus JL, Liu Y, Wallis KT, Egertová M, Bhartur SG, Mukhopadhyay S, Shi S, He H, Selley DE, Howlett AC, Elphick MR, Lewis DL. CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. Molecular Pharmacology. 72: 1557-66. PMID 17895407 DOI: 10.1124/Mol.107.039263 |
0.74 |
|
| 2007 |
Willardson BM, Howlett AC. Function of phosducin-like proteins in G protein signaling and chaperone-assisted protein folding. Cellular Signalling. 19: 2417-27. PMID 17658730 DOI: 10.1016/j.cellsig.2007.06.013 |
0.322 |
|
| 2007 |
Anavi-Goffer S, Fleischer D, Hurst DP, Lynch DL, Barnett-Norris J, Shi S, Lewis DL, Mukhopadhyay S, Howlett AC, Reggio PH, Abood ME. Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms. The Journal of Biological Chemistry. 282: 25100-13. PMID 17595161 DOI: 10.1074/Jbc.M703388200 |
0.73 |
|
| 2007 |
Ward GR, Franklin SO, Gerald TM, Dempsey KT, Clodfelter DE, Krissinger DJ, Patel KM, Vrana KE, Howlett AC. Glucocorticoids plus opioids up-regulate genes that influence neuronal function. Cellular and Molecular Neurobiology. 27: 651-60. PMID 17554624 DOI: 10.1007/S10571-007-9151-3 |
0.491 |
|
| 2007 |
Grace CR, Cowsik SM, Shim JY, Welsh WJ, Howlett AC. Unique helical conformation of the fourth cytoplasmic loop of the CB1 cannabinoid receptor in a negatively charged environment. Journal of Structural Biology. 159: 359-68. PMID 17524664 DOI: 10.1016/J.Jsb.2007.04.004 |
0.458 |
|
| 2007 |
Stephens-Hernandez AB, Livingston JN, Dacons-Brock K, Craft HL, Cameron A, Franklin SO, Howlett AC. Drama-based education to motivate participation in substance abuse prevention. Substance Abuse Treatment, Prevention, and Policy. 2: 11. PMID 17411423 DOI: 10.1186/1747-597X-2-11 |
0.312 |
|
| 2007 |
McCollum L, Howlett AC, Mukhopadhyay S. Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells. The Journal of Pharmacology and Experimental Therapeutics. 321: 930-7. PMID 17379772 DOI: 10.1124/Jpet.106.117549 |
0.699 |
|
| 2007 |
Awumey EM, Howlett AC, Putney JW, Diz DI, Bukoski RD. Ca(2+) mobilization through dorsal root ganglion Ca(2+)-sensing receptor stably expressed in HEK293 cells. American Journal of Physiology. Cell Physiology. 292: C1895-905. PMID 17267550 DOI: 10.1152/Ajpcell.00404.2006 |
0.374 |
|
| 2006 |
Howlett AC, Mukhopadhyay S, Norford DC. Endocannabinoids and reactive nitrogen and oxygen species in neuropathologies. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 1: 305-16. PMID 18040807 DOI: 10.1007/S11481-006-9022-6 |
0.655 |
|
| 2006 |
Mukhopadhyay S, Das S, Williams EA, Moore D, Jones JD, Zahm DS, Ndengele MM, Lechner AJ, Howlett AC. Lipopolysaccharide and cyclic AMP regulation of CB(2) cannabinoid receptor levels in rat brain and mouse RAW 264.7 macrophages. Journal of Neuroimmunology. 181: 82-92. PMID 17045344 DOI: 10.1016/J.Jneuroim.2006.08.002 |
0.736 |
|
| 2006 |
Shim JY, Howlett AC. WIN55212-2 docking to the CB1 cannabinoid receptor and multiple pathways for conformational induction. Journal of Chemical Information and Modeling. 46: 1286-300. PMID 16711748 DOI: 10.1021/Ci0504824 |
0.529 |
|
| 2006 |
Gerald TM, Ward GR, Howlett AC, Franklin SO. CB1 knockout mice display significant changes in striatal opioid peptide and D4 dopamine receptor gene expression. Brain Research. 1093: 20-4. PMID 16684513 DOI: 10.1016/J.Brainres.2006.03.088 |
0.542 |
|
| 2006 |
Norford DC, Carney ST, Arrington VI, Jones JD, Lloyd ML, Howlett AC. P049. Cannabinoid-mediated nitric oxide signal transduction in N18TG2 neuronal cells Nitric Oxide. 14: 33. DOI: 10.1016/J.Niox.2006.04.110 |
0.363 |
|
| 2005 |
Howlett AC. Cannabinoid receptor signaling Handbook of Experimental Pharmacology. 168: 53-79. PMID 16596771 DOI: 10.1007/3-540-26573-2_2 |
0.574 |
|
| 2005 |
Awumey EM, Howlett AC, Diz DI. Is there a role for anandamide in cardiovascular regulation? Insights from studies of endocannabinoid metabolism. American Journal of Physiology. Heart and Circulatory Physiology. 289: H520-1. PMID 16014613 DOI: 10.1152/Ajpheart.00433.2005 |
0.338 |
|
| 2005 |
Howlett AC. A short guide to the nomenclature of seven-transmembrane spanning receptors for lipid mediators. Life Sciences. 77: 1522-30. PMID 15953619 DOI: 10.1016/J.Lfs.2005.05.003 |
0.522 |
|
| 2005 |
Mukhopadhyay S, Howlett AC. Chemically distinct ligands promote differential CB1 cannabinoid receptor-Gi protein interactions. Molecular Pharmacology. 67: 2016-24. PMID 15749995 DOI: 10.1124/Mol.104.003558 |
0.711 |
|
| 2004 |
Howlett AC, Breivogel CS, Childers SR, Deadwyler SA, Hampson RE, Porrino LJ. Cannabinoid physiology and pharmacology: 30 years of progress. Neuropharmacology. 47: 345-58. PMID 15464149 DOI: 10.1016/J.Neuropharm.2004.07.030 |
0.571 |
|
| 2004 |
Howlett AC. Efficacy in CB1 receptor-mediated signal transduction. British Journal of Pharmacology. 142: 1209-18. PMID 15308578 DOI: 10.1038/Sj.Bjp.0705881 |
0.569 |
|
| 2004 |
Shim JY, Howlett AC. Steric trigger as a mechanism for CB1 cannabinoid receptor activation. Journal of Chemical Information and Computer Sciences. 44: 1466-76. PMID 15272855 DOI: 10.1021/Ci040040C |
0.505 |
|
| 2003 |
Shim JY, Welsh WJ, Howlett AC. Homology model of the CB1 cannabinoid receptor: sites critical for nonclassical cannabinoid agonist interaction. Biopolymers. 71: 169-89. PMID 12767117 DOI: 10.1002/Bip.10424 |
0.526 |
|
| 2002 |
Mukhopadhyay S, Shim JY, Assi AA, Norford D, Howlett AC. CB(1) cannabinoid receptor-G protein association: a possible mechanism for differential signaling. Chemistry and Physics of Lipids. 121: 91-109. PMID 12505694 DOI: 10.1016/S0009-3084(02)00153-6 |
0.729 |
|
| 2002 |
Howlett AC. The cannabinoid receptors. Prostaglandins & Other Lipid Mediators. 68: 619-31. PMID 12432948 DOI: 10.1016/S0090-6980(02)00060-6 |
0.569 |
|
| 2002 |
Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacological Reviews. 54: 161-202. PMID 12037135 DOI: 10.1124/Pr.54.2.161 |
0.67 |
|
| 2002 |
Mukhopadhyay S, Chapnick BM, Howlett AC. Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and independent. American Journal of Physiology. Heart and Circulatory Physiology. 282: H2046-54. PMID 12003810 DOI: 10.1152/Ajpheart.00497.2001 |
0.713 |
|
| 2002 |
Shim JY, Welsh WJ, Cartier E, Edwards JL, Howlett AC. Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor. Journal of Medicinal Chemistry. 45: 1447-59. PMID 11906286 DOI: 10.1021/Jm010267O |
0.506 |
|
| 2002 |
Klein C, Sunahara RK, Hudson TY, Heyduk T, Howlett AC. Zinc inhibition of cAMP signaling. The Journal of Biological Chemistry. 277: 11859-65. PMID 11805091 DOI: 10.1074/Jbc.M108808200 |
0.625 |
|
| 2001 |
Meschler JP, Howlett AC, Madras BK. Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates. Psychopharmacology. 156: 79-85. PMID 11465637 DOI: 10.1007/S002130100728 |
0.792 |
|
| 2001 |
Hudson TY, Corbett JA, Howlett AC, Klein C. Nitric oxide regulates adenylyl cyclase activity in rat striatal membranes Journal of Neurochemistry. 77: 1279-1284. PMID 11389178 DOI: 10.1046/J.1471-4159.2001.00331.X |
0.465 |
|
| 2001 |
Meschler JP, Howlett AC. Signal transduction interactions between CB1 cannabinoid and dopamine receptors in the rat and monkey striatum. Neuropharmacology. 40: 918-26. PMID 11378162 DOI: 10.1016/S0028-3908(01)00012-0 |
0.808 |
|
| 2001 |
Mukhopadhyay S, Howlett AC. CB1 receptor-G protein association: Subtype selectivity is determined by distinct intracellular domains European Journal of Biochemistry. 268: 499-505. PMID 11168387 DOI: 10.1046/J.1432-1327.2001.01810.X |
0.559 |
|
| 2000 |
Meschler JP, Conley TJ, Howlett AC. Cannabinoid and dopamine interaction in rodent brain: effects on locomotor activity. Pharmacology, Biochemistry, and Behavior. 67: 567-73. PMID 11164087 DOI: 10.1016/S0091-3057(00)00390-7 |
0.793 |
|
| 2000 |
Howlett AC, Mukhopadhyay S. Cellular signal transduction by anandamide and 2-arachidonoylglycerol Chemistry and Physics of Lipids. 108: 53-70. PMID 11106782 DOI: 10.1016/S0009-3084(00)00187-0 |
0.55 |
|
| 2000 |
Meschler JP, Kraichely DM, Wilken GH, Howlett AC. Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR141716A) and 1-(2-chlorophenyl)-4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxyl ic acid phenylamide (CP-272871) for the CB(1) cannabinoid receptor. Biochemical Pharmacology. 60: 1315-23. PMID 11008125 DOI: 10.1016/S0006-2952(00)00447-0 |
0.816 |
|
| 2000 |
Berglund BA, Fleming PR, Rice KC, Shim JY, Welsh WJ, Howlett AC. Development of a novel class of monocyclic and bicyclic alkyl amides that exhibit CB1 and CB2 cannabinoid receptor affinity and receptor activation. Drug Design and Discovery. 16: 281-94. PMID 10807034 |
0.468 |
|
| 2000 |
Howlett AC, Wilken GH, Pigg JJ, Houston DB, Lan R, Liu Q, Makriyannis A. Azido- and isothiocyanato-substituted aryl pyrazoles bind covalently to the CB1 cannabinoid receptor and impair signal transduction. Journal of Neurochemistry. 74: 2174-81. PMID 10800963 DOI: 10.1046/J.1471-4159.2000.0742174.X |
0.552 |
|
| 2000 |
Hill J, Howlett A, Klein C. Nitric oxide selectively inhibits adenylyl cyclase isoforms 5 and 6 Cellular Signalling. 12: 233-237. PMID 10781930 DOI: 10.1016/S0898-6568(99)00082-0 |
0.411 |
|
| 2000 |
Meschler JP, Clarkson FA, Mathews PJ, Howlett AC, Madras BK. D(2), but not D(1) dopamine receptor agonists potentiate cannabinoid-induced sedation in nonhuman primates. The Journal of Pharmacology and Experimental Therapeutics. 292: 952-9. PMID 10688609 |
0.799 |
|
| 2000 |
Mukhopadhyay S, McIntosh HH, Houston DB, Howlett AC. The CB(1) cannabinoid receptor juxtamembrane C-terminal peptide confers activation to specific G proteins in brain. Molecular Pharmacology. 57: 162-70. PMID 10617691 |
0.464 |
|
| 1999 |
Berglund BA, Boring DL, Howlett AC. Investigation of structural analogs of prostaglandin amides for binding to and activation of CB1 and CB2 cannabinoid receptors in rat brain and human tonsils. Advances in Experimental Medicine and Biology. 469: 527-33. PMID 10667378 DOI: 10.1007/978-1-4615-4793-8_77 |
0.534 |
|
| 1999 |
Howlett AC, Mukhopadhyay S, Shim JY, Welsh WJ. Signal transduction of eicosanoid CB1 receptor ligands Life Sciences. 65: 617-625. PMID 10462062 DOI: 10.1016/S0024-3205(99)00284-2 |
0.561 |
|
| 1999 |
McVey M, Hill J, Howlett A, Klein C. Adenylyl cyclase, a coincidence detector for nitric oxide. The Journal of Biological Chemistry. 274: 18887-92. PMID 10383385 DOI: 10.1074/Jbc.274.27.18887 |
0.425 |
|
| 1999 |
Meschler JP, Howlett AC. Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses. Pharmacology, Biochemistry, and Behavior. 62: 473-80. PMID 10080239 DOI: 10.1016/S0091-3057(98)00195-6 |
0.821 |
|
| 1999 |
Mukhopadhyay S, Cowsik SM, Lynn AM, Welsh WJ, Howlett AC. Regulation of G(i) by the CB1 cannabinoid receptor C-terminal juxtamembrane region: Structural requirements determined by peptide analysis Biochemistry. 38: 3447-3455. PMID 10079092 DOI: 10.1021/Bi981767V |
0.429 |
|
| 1999 |
Shim JY, Collantes ER, Welsh WJ, Howlett AC. Unified pharmacophoric model for cannabinoids and aminoalkylindoles derived from molecular superimposition of CB1 cannabinoid receptor agonists CP55244 and WIN55212-2 Acs Symposium Series. 719: 165-184. |
0.403 |
|
| 1998 |
Howlett AC. The CB1 cannabinoid receptor in the brain Neurobiology of Disease. 5: 405-416. PMID 9974174 DOI: 10.1006/Nbdi.1998.0215 |
0.576 |
|
| 1998 |
Ruh MF, Bi Y, Cox L, Berk D, Howlett AC, Bellone CJ. Effect of environmental estrogens on IL-1beta promoter activity in a macrophage cell line. Endocrine. 9: 207-11. PMID 9867255 DOI: 10.1385/Endo:9:2:207 |
0.408 |
|
| 1998 |
Shim JY, Collantes ER, Welsh WJ, Subramaniam B, Howlett AC, Eissenstat MA, Ward SJ. Three-dimensional quantitative structure-activity relationship study of the cannabimimetic (aminoalkyl)indoles using comparative molecular field analysis. Journal of Medicinal Chemistry. 41: 4521-32. PMID 9804691 DOI: 10.1021/Jm980305C |
0.454 |
|
| 1998 |
Houston DB, Howlett AC. Differential receptor-G-protein coupling evoked by dissimilar cannabinoid receptor agonists. Cellular Signalling. 10: 667-74. PMID 9794249 DOI: 10.1016/S0898-6568(98)00013-8 |
0.551 |
|
| 1998 |
Tong W, Collantes ER, Welsh WJ, Berglund BA, Howlett AC. Derivation of a pharmacophore model for anandamide using constrained conformational searching and comparative molecular field analysis. Journal of Medicinal Chemistry. 41: 4207-15. PMID 9784095 DOI: 10.1021/Jm970239Z |
0.432 |
|
| 1998 |
Berglund BA, Boring DL, Wilken GH, Makriyannis A, Howlett AC, Lin S. Structural requirements for arachidonylethanolamide interaction with CB1 and CB2 cannabinoid receptors: pharmacology of the carbonyl and ethanolamide groups. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 59: 111-8. PMID 9774174 DOI: 10.1016/S0952-3278(98)90089-8 |
0.55 |
|
| 1998 |
Howlett AC, Song C, Berglund BA, Wilken GH, Pigg JJ. Characterization of CB1 cannabinoid receptors using receptor peptide fragments and site-directed antibodies. Molecular Pharmacology. 53: 504-10. PMID 9495818 DOI: 10.1124/Mol.53.3.504 |
0.487 |
|
| 1998 |
McIntosh HH, Song C, Howlett AC. CB1 cannabinoid receptor: cellular regulation and distribution in N18TG2 neuroblastoma cells. Brain Research. Molecular Brain Research. 53: 163-73. PMID 9473654 DOI: 10.1016/S0169-328X(97)00294-5 |
0.556 |
|
| 1997 |
Tao YP, Misko TP, Howlett AC, Klein C. Nitric oxide, an endogenous regulator of Dictyostelium discoideum differentiation Development. 124: 3587-3595. PMID 9342051 |
0.292 |
|
| 1997 |
Deutsch DG, Omeir R, Arreaza G, Salehani D, Prestwich GD, Huang Z, Howlett A. Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase. Biochemical Pharmacology. 53: 255-60. PMID 9065728 DOI: 10.1016/S0006-2952(96)00830-1 |
0.485 |
|
| 1997 |
Ruh MF, Taylor JA, Howlett AC, Welshons WV. Failure of cannabinoid compounds to stimulate estrogen receptors Biochemical Pharmacology. 53: 35-41. PMID 8960061 DOI: 10.1016/S0006-2952(96)00659-4 |
0.511 |
|
| 1996 |
Boring DL, Berglund BA, Howlett AC. Cerebrodiene, arachidonyl-ethanolamide, and hybrid structures: potential for interaction with brain cannabinoid receptors. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 55: 207-10. PMID 8931121 DOI: 10.1016/S0952-3278(96)90100-3 |
0.515 |
|
| 1996 |
Tao Y, Howlett A, Klein C. Nitric oxide inhibits the initiation of cAMP pulsing in D. discoideum without altering receptor-activated adenylate cyclase. Cellular Signalling. 8: 26-34. PMID 8777138 DOI: 10.1016/0898-6568(95)02011-X |
0.51 |
|
| 1996 |
Yamada K, Rice KC, Flippen-Anderson JL, Eissenstat MA, Ward SJ, Johnson MR, Howlett AC. (Aminoalkyl)indole isothiocyanates as potential electrophilic affinity ligands for the brain cannabinoid receptor. Journal of Medicinal Chemistry. 39: 1967-74. PMID 8642555 DOI: 10.1021/jm950932r |
0.399 |
|
| 1995 |
Melvin LS, Milne GM, Johnson MR, Wilken GH, Howlett AC. Structure-activity relationships defining the ACD-tricyclic cannabinoids: cannabinoid receptor binding and analgesic activity. Drug Design and Discovery. 13: 155-66. PMID 8872458 |
0.435 |
|
| 1995 |
Song C, Howlett AC. Rat brain cannabinoid receptors are N-linked glycosylated proteins Life Sciences. 56: 1983-1989. PMID 7776822 DOI: 10.1016/0024-3205(95)00179-A |
0.505 |
|
| 1995 |
Belue RC, Howlett AC, Westlake TM, Hutchings DE. The ontogeny of cannabinoid receptors in the brain of postnatal and aging rats Neurotoxicology and Teratology. 17: 25-30. PMID 7708016 DOI: 10.1016/0892-0362(94)00053-G |
0.535 |
|
| 1995 |
Howlett AC. Pharmacology of cannabinoid receptors Annual Review of Pharmacology and Toxicology. 35: 607-634. PMID 7598509 DOI: 10.1146/Annurev.Pa.35.040195.003135 |
0.576 |
|
| 1994 |
Evans DM, Lake JT, Johnson MR, Howlett AC. Endogenous cannabinoid receptor binding activity released from rat brain slices by depolarization Journal of Pharmacology and Experimental Therapeutics. 268: 1271-1277. PMID 8138940 |
0.467 |
|
| 1994 |
Koutek B, Prestwich GD, Howlett AC, Chin SA, Salehani D, Akhavan N, Deutsch DG. Inhibitors of arachidonoyl ethanolamide hydrolysis. The Journal of Biological Chemistry. 269: 22937-40. PMID 8083191 |
0.36 |
|
| 1994 |
Pinto JC, Potié F, Rice KC, Boring D, Johnson MR, Evans DM, Wilken GH, Cantrell CH, Howlett AC. Cannabinoid receptor binding and agonist activity of amides and esters of arachidonic acid Molecular Pharmacology. 46: 516-522. PMID 7935333 |
0.327 |
|
| 1994 |
Tao Y, Howlett A, Klein C. Nitric oxide regulation of glyceraldehyde-3-phosphate dehydrogenase activity in Dictyostelium discoideum cells and lysates. European Journal of Biochemistry. 224: 447-54. PMID 7925359 DOI: 10.1111/J.1432-1033.1994.00447.X |
0.414 |
|
| 1994 |
Westlake TM, Howlett AC, Bonner TI, Matsuda LA, Herkenham M. Cannabinoid receptor binding and messenger RNA expression in human brain: an in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brains. Neuroscience. 63: 637-52. PMID 7898667 DOI: 10.1016/0306-4522(94)90511-8 |
0.477 |
|
| 1994 |
Martin BR, Childers S, Howlett A, Mechoulam R, Pertwee R. Cannabinoid receptors: Pharmacology, second messenger systems and endogenous ligands Nida Research Monograph Series. 55-60. |
0.419 |
|
| 1993 |
Houston DB, Howlett AC. Solubilization of the cannabinoid receptor from rat brain and its functional interaction with guanine nucleotide-binding proteins. Molecular Pharmacology. 43: 17-22. PMID 8423766 |
0.495 |
|
| 1993 |
Melvin LS, Milne GM, Johnson MR, Subramaniam B, Wilken GH, Howlett AC. Structure-activity relationships for cannabinoid receptor-binding and analgesic activity: studies of bicyclic cannabinoid analogs. Molecular Pharmacology. 44: 1008-15. PMID 8246904 |
0.461 |
|
| 1993 |
Wessels-Reiker M, Basiboina R, Howlett AC, Strong R. Vasoactive intestinal polypeptide-related peptides modulate tyrosine hydroxylase gene expression in PC12 cells through multiple adenylate cyclase-coupled receptors. Journal of Neurochemistry. 60: 1018-29. PMID 8094740 DOI: 10.1111/J.1471-4159.1993.Tb03250.X |
0.43 |
|
| 1993 |
Tao Y, Howlett AC, Klein C. Endogenous ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase that is not regulated by nitric oxide in Dictyostelium discoideum Cellular Signalling. 5: 763-775. PMID 7907497 DOI: 10.1016/0898-6568(93)90037-M |
0.416 |
|
| 1992 |
Evans DM, Johnson MR, Howlett AC. Ca2+ ‐Dependent Release from Rat Brain of Cannabinoid Receptor Binding Activity Journal of Neurochemistry. 58: 780-782. PMID 1729420 DOI: 10.1111/j.1471-4159.1992.tb09787.x |
0.396 |
|
| 1992 |
Houston DB, Howlett AC. Solubilization of the cannabinoid receptor from rat brain membranes. Annals of the New York Academy of Sciences. 654: 448-50. PMID 1632600 DOI: 10.1111/J.1749-6632.1992.Tb25994.X |
0.477 |
|
| 1992 |
Tao Y, Howlett A, Klein C. Nitric oxide-releasing compounds inhibit Dictyostelium discoideum aggregation without altering cGMP production. Febs Letters. 314: 49-52. PMID 1360411 DOI: 10.1016/0014-5793(92)81459-Y |
0.42 |
|
| 1992 |
Tao Y, Howlett A, Klein C. Nitric oxide stimulates the ADP-ribosylation of a 41-kDa cytosolic protein in Dictyostelium discoideum. Proceedings of the National Academy of Sciences of the United States of America. 89: 5902-6. PMID 1352880 DOI: 10.1073/Pnas.89.13.5902 |
0.407 |
|
| 1992 |
Charalambous A, Yan G, Houston DB, Howlett AC, Compton DR, Martin BR, Makriyannis A. 5'-Azido-delta 8-THC: a novel photoaffinity label for the cannabinoid receptor. Journal of Medicinal Chemistry. 35: 3076-9. PMID 1323683 DOI: 10.1021/Jm00094A023 |
0.622 |
|
| 1991 |
Courtney ND, Howlett AC, Westfall TC. Regulation of nicotine-evoked dopamine release from PC12 cells. Life Sciences. 48: 1671-8. PMID 1850061 DOI: 10.1016/0024-3205(91)90127-W |
0.398 |
|
| 1991 |
Courtney ND, Howlett AC, Westfall TC. Dopaminergic regulation of dopamine release from PC12 cells via a pertussis toxin-sensitive G protein. Neuroscience Letters. 122: 261-4. PMID 1827517 DOI: 10.1016/0304-3940(91)90873-R |
0.438 |
|
| 1991 |
Howlett AC, Champion-Dorow TM, McMahon LL, Westlake TM. The cannabinoid receptor: biochemical and cellular properties in neuroblastoma cells. Pharmacology, Biochemistry, and Behavior. 40: 565-9. PMID 1806946 DOI: 10.1016/0091-3057(91)90364-8 |
0.596 |
|
| 1991 |
Bidaut-Russell M, Howlett AC. Cannabinoid receptor-regulated cyclic AMP accumulation in the rat striatum. Journal of Neurochemistry. 57: 1769-73. PMID 1681035 DOI: 10.1111/j.1471-4159.1991.tb06379.x |
0.445 |
|
| 1991 |
Wessels-Reiker M, Haycock JW, Howlett AC, Strong R. Vasoactive intestinal polypeptide induces tyrosine hydroxylase in PC12 cells Journal of Biological Chemistry. 266: 9347-9350. PMID 1674510 |
0.417 |
|
| 1991 |
O'Donnell KA, Howlett AC. Inhibition of adenylate cyclase by p-bromophenacyl bromide Biochemical Pharmacology. 42: 1941-1946. PMID 1660272 DOI: 10.1016/0006-2952(91)90593-T |
0.451 |
|
| 1991 |
O'Donnell KA, Howlett AC. Muscarinic receptor binding is inhibited by quinacrine Neuroscience Letters. 127: 46-48. PMID 1652714 DOI: 10.1016/0304-3940(91)90891-V |
0.513 |
|
| 1991 |
Westlake TM, Howlett AC, Ali SF, Paule MG, Scallet AC, Slikker W. Chronic exposure to delta 9-tetrahydrocannabinol fails to irreversibly alter brain cannabinoid receptors. Brain Research. 544: 145-9. PMID 1649662 DOI: 10.1016/0006-8993(91)90897-5 |
0.465 |
|
| 1990 |
Howlett AC. Reverse pharmacology applied to the cannabinoid receptor Trends in Pharmacological Sciences. 11: 395-397. PMID 2256177 DOI: 10.1016/0165-6147(90)90142-U |
0.561 |
|
| 1990 |
Coezy ED, Corvol P, Howlett AC. Involvement of a pertussis toxin-sensitive G protein in the regulation of angiotensinogen production by an angiotensin II analog in HepG2 cells Cellular Signalling. 2: 67-76. PMID 2176801 DOI: 10.1016/0898-6568(90)90034-8 |
0.448 |
|
| 1990 |
Howlett AC, Johnson MR, Melvin LS. Classical and nonclassical cannabinoids: mechanism of action--brain binding Nida Research Monograph. 96: 100-111. PMID 2172821 |
0.271 |
|
| 1990 |
Bidaut‐Russell M, Devane WA, Howlett AC. Cannabinoid Receptors and Modulation of Cyclic AMP Accumulation in the Rat Brain Journal of Neurochemistry. 55: 21-26. PMID 2162376 DOI: 10.1111/J.1471-4159.1990.Tb08815.X |
0.476 |
|
| 1990 |
Howlett AC, Champion TM, Wilken GH, Mechoulam R. Stereochemical effects of 11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor Neuropharmacology. 29: 161-165. PMID 2158635 DOI: 10.1016/0028-3908(90)90056-W |
0.525 |
|
| 1990 |
Howlett AC, Bidaut-Russell M, Devane WA, Melvin LS, Johnson MR, Herkenham M. The cannabinoid receptor: biochemical, anatomical and behavioral characterization. Trends in Neurosciences. 13: 420-3. PMID 1700516 DOI: 10.1016/0166-2236(90)90124-S |
0.53 |
|
| 1990 |
Howlett AC, Bidaut-Russell M, Champion-Dorow T, Devane WA, Westlake TM, Wilken GH, Melvin LS, Johnson MR. Cannabinoid receptors in the brain and cultured neuroblastoma cells European Journal of Pharmacology. 183: 2149-2150. DOI: 10.1016/0014-2999(90)93673-E |
0.385 |
|
| 1989 |
Howlett AC, Scott DK, Wilken GH. Regulation of adenylate cyclase by cannabinoid drugs. Insights based on thermodynamic studies Biochemical Pharmacology. 38: 3297-3304. PMID 2554920 DOI: 10.1016/0006-2952(89)90628-X |
0.429 |
|
| 1988 |
Howlett AC, Johnson MR, Melvin LS, Milne GM. Nonclassical cannabinoid analgetics inhibit adenylate cyclase: development of a cannabinoid receptor model. Molecular Pharmacology. 33: 297-302. PMID 3352594 |
0.499 |
|
| 1988 |
Khachatrian L, Klein C, Howlett A. Pertussis and cholera toxin ADP-ribosylation in Dictyostelium discoideum membranes. Biochemical and Biophysical Research Communications. 149: 975-81. PMID 3122750 DOI: 10.1016/0006-291X(87)90504-3 |
0.486 |
|
| 1988 |
Dill JA, Howlett AC. Regulation of adenylate cyclase by chronic exposure to cannabimimetic drugs Journal of Pharmacology and Experimental Therapeutics. 244: 1157-1163. PMID 2855242 |
0.365 |
|
| 1988 |
Devane WA, Dysarz FA, Johnson MR, Melvin LS, Howlett AC. Determination and characterization of a cannabinoid receptor in rat brain. Molecular Pharmacology. 34: 605-13. PMID 2848184 |
0.418 |
|
| 1988 |
Beinfeld MC, Brick PL, Howlett AC, Holt IL, Pruss RM, Moskal JR, Eiden LE. The regulation of vasoactive intestinal peptide synthesis in neuroblastoma and chromaffin cells. Annals of the New York Academy of Sciences. 527: 68-76. PMID 2839090 DOI: 10.1111/J.1749-6632.1988.Tb26973.X |
0.343 |
|
| 1987 |
Howlett AC. Cannabinoid inhibition of adenylate cyclase: Relative activity of constituents and metabolites of marihuana Neuropharmacology. 26: 507-512. PMID 3601007 DOI: 10.1016/0028-3908(87)90035-9 |
0.406 |
|
| 1987 |
Walz MA, Holt IL, Howlett AC. Cyclic nucleotide phosphodiesterase isozymes in neuroblastoma cells Journal of Neuroscience Research. 17: 291-297. PMID 3037096 DOI: 10.1002/Jnr.490170314 |
0.427 |
|
| 1987 |
Walz MA, Howlett AC. Thyroid effects on adenosine 3',5'-monophosphate levels and adenylate cyclase in cultured neuroblastoma cells Endocrinology. 120: 1265-1271. PMID 3030693 DOI: 10.1210/Endo-120-4-1265 |
0.397 |
|
| 1987 |
Khachatrian L, Klein C, Howlett A. Regulation of Dictyostelium discoideum adenylate cyclase by manganese and adenosine analogs. Biochimica Et Biophysica Acta. 927: 235-46. PMID 2880607 DOI: 10.1016/0167-4889(87)90140-6 |
0.467 |
|
| 1987 |
Howlett AC. Regulation of adenylate cyclase in a cultured neuronal cell line by marijuana constituents, metabolites of delta-9-tetrahydrocannabinol, and synthetic analogs having psychoactivity Nida Research Monograph. 79: 148-157. PMID 2830535 |
0.255 |
|
| 1987 |
Bidaut-Russell M, Howlett AC. Muscarinic pharmacology of the inhibition of adenylate cyclase in N18TG2 neuroblastoma cells Neurochemistry International. 11: 287-292. DOI: 10.1016/0197-0186(87)90048-9 |
0.489 |
|
| 1986 |
Ashley JS, Howlett A, Morris JN. Case-fatality of hyperplasia of the prostate in two teaching and three regional-board hospitals. Lancet (London, England). 2: 1308-11. PMID 4143551 DOI: 10.1016/S0140-6736(71)90619-2 |
0.176 |
|
| 1986 |
Devane WA, Spain JW, Coscia CJ, Howlett AC. An assessment of the role of opioid receptors in the response to cannabimimetic drugs. Journal of Neurochemistry. 46: 1929-35. PMID 3009717 DOI: 10.1111/J.1471-4159.1986.Tb08515.X |
0.468 |
|
| 1986 |
Howlett AC, Qualy JM, Khachatrian LL. Involvement of G(i) in the inhibition of adenylate cyclase by cannabimimetic drugs Molecular Pharmacology. 29: 307-313. PMID 2869405 |
0.414 |
|
| 1985 |
Brick PL, Howlett AC, Beinfeld MC. Synthesis and release of vasoactive intestinal polypeptide (VIP) by mouse neuroblastoma cells: modulation by cyclic nucleotides and ascorbic acid. Peptides. 6: 1075-8. PMID 3010255 DOI: 10.1016/0196-9781(85)90430-9 |
0.411 |
|
| 1985 |
Howlett AC. Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes Molecular Pharmacology. 27: 429-436. PMID 2984538 |
0.351 |
|
| 1985 |
Walz MA, Howlett AC. Cyclic AMP levels are increased in neuroblastoma cells grown in presence of thyroid hormone Federation Proceedings. 44. |
0.236 |
|
| 1984 |
Roth BL, Beinfeld MC, Howlett AC. Secretin Receptors on Neuroblastoma Cell Membranes: Characterization of 125I‐Labeled Secretin Binding and Association with Adenylate Cyclase Journal of Neurochemistry. 42: 1145-1152. PMID 6321661 DOI: 10.1111/J.1471-4159.1984.Tb12723.X |
0.496 |
|
| 1984 |
Howlett AC, Fleming RM. Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membrane Molecular Pharmacology. 26: 532-538. PMID 6092901 |
0.425 |
|
| 1984 |
Howlett AC. Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds Life Sciences. 35: 1803-1810. PMID 6090851 DOI: 10.1016/0024-3205(84)90278-9 |
0.476 |
|
| 1982 |
Howlett AC. Effects of NaCl concentration on adenylate cyclase regulation by prostaglandins and guanine nucleotides Journal of Cyclic Nucleotide Research. 8: 91-102. PMID 6757290 |
0.348 |
|
| 1982 |
Howlett AC. Stimulation of neuroblastoma adenylate cyclase by arachidonic acid metabolites Molecular Pharmacology. 21: 664-670. PMID 6287201 |
0.439 |
|
| 1981 |
Howlett AC. Prostacyclin-stimulated adenylate cyclase in neuroblastoma cells Pharmacologist. 23. |
0.282 |
|
| 1980 |
Howlett AC, Gilman AG. Hydrodynamic properties of the regulatory component of adenylate cyclase Journal of Biological Chemistry. 255: 2861-2866. PMID 6244297 |
0.657 |
|
| 1979 |
Ross EM, Howlett AC, Gilman AG. Identification and partial characterization of some components of hormone-stimulated adenylate cyclase. Progress in Clinical and Biological Research. 31: 735-49. PMID 231786 |
0.75 |
|
| 1979 |
Howlett AC, Sternweis PC, Macik BA, Van Arsdale PM, Gilman AG. Reconstitution of catecholamine-sensitive adenylate cyclase. Association of a regulatory component of the enzyme with membranes containing the catalytic protein and β-adrenergic receptors Journal of Biological Chemistry. 254: 2287-2295. PMID 218930 |
0.706 |
|
| 1978 |
Burgess WH, Howlett AC, Kretsinger RH, Gilman AG. S49 lymphoma wild type and variant clones contain normal calcium dependent regulator Journal of Cyclic Nucleotide Research. 4: 175-181. PMID 214461 |
0.65 |
|
| 1978 |
Howlett AC, Van Arsdale PM, Gilman AG. Efficiency of coupling between the beta adrenergic receptor and adenylate cyclase Molecular Pharmacology. 14: 531-539. PMID 210367 |
0.689 |
|
| 1978 |
Ross EM, Howlett AC, Ferguson KM, Gilman AG. Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme. The Journal of Biological Chemistry. 253: 6401-12. PMID 210183 DOI: 10.1016/B978-0-08-023768-8.51834-X |
0.752 |
|
| 1978 |
Howlett AC, Breckenridge BM. The distribution of cyclic nucleotide phosphodiesterase in the hypothalamus. Journal of Neurochemistry. 31: 321-7. PMID 209146 DOI: 10.1111/j.1471-4159.1978.tb12465.x |
0.69 |
|
| 1978 |
Ross EM, Haga T, Howlett AC, Schwarzmeier J, Schleifer LS, Gilman AG. Hormone-sensitive adenylate cyclase: resolution and reconstitution of some components necessary for regulation of the enzyme. Advances in Cyclic Nucleotide Research. 9: 53-68. PMID 208395 |
0.708 |
|
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