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Steven E. Ealick - Publications

Affiliations: 
Chemistry and Chemical Biology Cornell University, Ithaca, NY, United States 
Area:
structure and function of proteins using X-ray crystallography
Website:
http://chemistry.cornell.edu/faculty/detail.cfm?netid=see3
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Year Citation  Score
2020 Fenwick MK, Su D, Dong M, Lin H, Ealick SE. Structural basis of substrate selectivity of viperin. Biochemistry. PMID 31917549 DOI: 10.1021/Acs.Biochem.9B00741  0.496
2020 Parker WB, Allan PW, Waud WR, Hong J, Gilbert-Ross M, Achyut BR, Joshi D, Behbahani T, Rab R, Ealick SE, Sorscher EJ. The use of Trichomonas vaginalis purine nucleoside phosphorylase to activate fludarabine in the treatment of solid tumors. Cancer Chemotherapy and Pharmacology. PMID 31915968 DOI: 10.1007/S00280-019-04018-7  0.302
2019 Fenwick MK, Dong M, Lin H, Ealick SE. Crystal structure of Dph2 in complex with elongation factor 2 reveals structural basis for first step of diphthamide biosynthesis. Biochemistry. PMID 31566354 DOI: 10.1021/Acs.Biochem.9B00718  0.52
2019 Mahanta N, Hicks KA, Naseem S, Fedoseyenko D, Ealick SE, Begley TP. Menaquinone Biosynthesis: Biochemical and Structural Studies on chorismate dehydratase. Biochemistry. PMID 30855131 DOI: 10.1021/Acs.Biochem.9B00105  0.389
2018 Fenwick MK, Ealick SE. Towards the structural characterization of the human methyltransferome. Current Opinion in Structural Biology. 53: 12-21. PMID 29654888 DOI: 10.1016/J.Sbi.2018.03.007  0.463
2018 Dong M, Kathiresan V, Fenwick MK, Torelli AT, Zhang Y, Caranto JD, Dzikovski B, Sharma A, Lancaster KM, Freed JH, Ealick SE, Hoffman BM, Lin H. Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science (New York, N.Y.). 359: 1247-1250. PMID 29590073 DOI: 10.1126/Science.Aao6595  0.362
2017 Fenwick MK, Almabruk KH, Ealick SE, Begley TP, Philmus B. Biochemical characterization and structural basis of reactivity and regioselectivity differences of Burkholderia thailandensis and Burkholderia glumae 1,6-didesmethyltoxoflavin N-methyltransferase. Biochemistry. PMID 28665591 DOI: 10.1021/Acs.Biochem.7B00476  0.385
2017 Fenwick MK, Li Y, Cresswell P, Modis Y, Ealick SE. Structural studies of viperin, an antiviral radical SAM enzyme. Proceedings of the National Academy of Sciences of the United States of America. PMID 28607080 DOI: 10.1073/Pnas.1705402114  0.541
2017 Dong M, Horitani M, Dzikovski B, Freed JH, Ealick S, Hoffman BM, Lin H. Substrate-Dependent Cleavage Site Selection by Unconventional Radical SAM Enzymes in Diphthamide Biosynthesis. Journal of the American Chemical Society. PMID 28383907 DOI: 10.1021/Jacs.7B01712  0.357
2017 Rodrigues MJ, Windeisen V, Zhang Y, Guédez G, Weber S, Strohmeier M, Hanes JW, Royant A, Evans G, Sinning I, Ealick SE, Begley TP, Tews I. Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nature Chemical Biology. PMID 28092359 DOI: 10.1038/Nchembio.2273  0.496
2016 Zhang K, Bian J, Deng Y, Smith A, Nunez RE, Li MB, Pal U, Yu AM, Qiu W, Ealick SE, Li C. Lyme disease spirochaete Borrelia burgdorferi does not require thiamin. Nature Microbiology. 2: 16213. PMID 27869793 DOI: 10.1038/Nmicrobiol.2016.213  0.348
2016 Fenwick MK, Ealick SE. Crystal structures of the iron sulfur cluster dependent quinolinate synthase in complex with dihydroxyacetone phosphate, iminoaspartate analogs, and quinolinate. Biochemistry. PMID 27404889 DOI: 10.1021/Acs.Biochem.6B00626  0.396
2016 Hicks KA, Ealick SE. Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway. Acta Crystallographica. Section D, Structural Biology. 72: 808-816. PMID 27303801 DOI: 10.1107/S2059798316007099  0.445
2016 Fenwick MK, Philmus B, Begley TP, Ealick SE. Burkholderia glumae ToxA is a Dual Specificity Methyltransferase that Catalyzes the Last Two Steps of Toxoflavin Biosynthesis. Biochemistry. PMID 27070241 DOI: 10.1021/Acs.Biochem.6B00167  0.444
2016 Eser BE, Zhang X, Chanani PK, Begley TP, Ealick SE. From suicide enzyme to catalyst: the iron-dependent sulfide transfer in Methanococcus jannaschii thiamin thiazole biosynthesis. Journal of the American Chemical Society. PMID 26928142 DOI: 10.1021/Jacs.6B00445  0.446
2016 Zhang X, Eser BE, Chanani PK, Begley TP, Ealick SE. Structural Basis for Iron-mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases. Biochemistry. PMID 26919468 DOI: 10.1021/Acs.Biochem.6B00030  0.353
2016 Mori S, Simkhada D, Zhang H, Erb MS, Zhang Y, Williams HJ, Fedoseyenko D, Russell WK, Kim D, Fleer N, Ealick SE, Watanabe CM. Polyketide Ring Expansion Mediated by a Thioesterase, CEC Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG. Biochemistry. PMID 26731610 DOI: 10.1021/Acs.Biochem.5B01050  0.713
2015 Li B, Kim SH, Zhang Y, Hanfrey CC, Elliott KA, Ealick SE, Michael AJ. Different polyamine pathways from bacteria have replaced eukaryotic spermidine biosynthesis in ciliates Tetrahymena thermophila and Paramecium tetaurelia. Molecular Microbiology. PMID 25994085 DOI: 10.1111/Mmi.13066  0.407
2015 Fenwick MK, Mehta AP, Zhang Y, Abdelwahed SH, Begley TP, Ealick SE. Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase. Nature Communications. 6: 6480. PMID 25813242 DOI: 10.1038/Ncomms7480  0.446
2015 Mehta AP, Abdelwahed SH, Mahanta N, Fedoseyenko D, Philmus B, Cooper LE, Liu Y, Jhulki I, Ealick SE, Begley TP. Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: a treasure trove of complex organic radical rearrangement reactions. The Journal of Biological Chemistry. 290: 3980-6. PMID 25477515 DOI: 10.1074/Jbc.R114.623793  0.37
2014 Ye W, Paul D, Gao L, Seckute J, Sangaiah R, Jayaraj K, Zhang Z, Kaminski PA, Ealick SE, Gold A, Ball LM. Ethenoguanines undergo glycosylation by nucleoside 2'-deoxyribosyltransferases at non-natural sites. Plos One. 9: e115082. PMID 25521390 DOI: 10.1371/Journal.Pone.0115082  0.61
2014 Sasaki E, Zhang X, Sun HG, Lu MY, Liu TL, Ou A, Li JY, Chen YH, Ealick SE, Liu HW. Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis. Nature. 510: 427-31. PMID 24814342 DOI: 10.1038/nature13256  0.33
2013 Sikowitz MD, Shome B, Zhang Y, Begley TP, Ealick SE. Structure of a Clostridium botulinum C143S thiaminase I/thiamin complex reveals active site architecture . Biochemistry. 52: 7830-9. PMID 24079939 DOI: 10.1021/Bi400841G  0.524
2013 Soriano EV, Zhang Y, Colabroy KL, Sanders JM, Settembre EC, Dorrestein PC, Begley TP, Ealick SE. Active-site models for complexes of quinolinate synthase with substrates and intermediates. Acta Crystallographica. Section D, Biological Crystallography. 69: 1685-96. PMID 23999292 DOI: 10.1107/S090744491301247X  0.807
2013 Sikowitz MD, Cooper LE, Begley TP, Kaminski PA, Ealick SE. Reversal of the substrate specificity of CMP N-glycosidase to dCMP. Biochemistry. 52: 4037-47. PMID 23659472 DOI: 10.1021/Bi400316P  0.532
2013 Hicks KA, O'Leary SE, Begley TP, Ealick SE. Structural and mechanistic studies of HpxO, a novel flavin adenine dinucleotide-dependent urate oxidase from Klebsiella pneumoniae. Biochemistry. 52: 477-87. PMID 23259842 DOI: 10.1021/Bi301262P  0.433
2012 Huang S, Mahanta N, Begley TP, Ealick SE. Pseudouridine monophosphate glycosidase: a new glycosidase mechanism. Biochemistry. 51: 9245-55. PMID 23066817 DOI: 10.1021/Bi3006829  0.496
2012 Knaus T, Eger E, Koop J, Stipsits S, Kinsland CL, Ealick SE, Macheroux P. Reverse structural genomics: an unusual flavin-binding site in a putative protease from Bacteroides thetaiotaomicron. The Journal of Biological Chemistry. 287: 27490-8. PMID 22718753 DOI: 10.1074/Jbc.M112.355388  0.429
2012 Lai RY, Huang S, Fenwick MK, Hazra A, Zhang Y, Rajashankar K, Philmus B, Kinsland C, Sanders JM, Ealick SE, Begley TP. Thiamin pyrimidine biosynthesis in Candida albicans : a remarkable reaction between histidine and pyridoxal phosphate. Journal of the American Chemical Society. 134: 9157-9. PMID 22568620 DOI: 10.1021/Ja302474A  0.524
2012 Zhang Y, Zwart PH, Ealick SE. A corrected space group for Sulfolobus sulfataricus 5'-deoxy-5'-methylthioadenosine phosphorylase II. Acta Crystallographica. Section D, Biological Crystallography. 68: 249-52. PMID 22349226 DOI: 10.1107/S0907444911051699  0.307
2012 Dessanti P, Zhang Y, Allegrini S, Tozzi MG, Sgarrella F, Ealick SE. Structural basis of the substrate specificity of Bacillus cereus adenosine phosphorylase. Acta Crystallographica. Section D, Biological Crystallography. 68: 239-48. PMID 22349225 DOI: 10.1107/S090744491200073X  0.506
2012 Philmus B, Abdelwahed S, Williams HJ, Fenwick MK, Ealick SE, Begley TP. Identification of the product of toxoflavin lyase: degradation via a Baeyer-Villiger oxidation. Journal of the American Chemical Society. 134: 5326-30. PMID 22304755 DOI: 10.1021/Ja211759N  0.342
2011 Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP. Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase. Nature. 478: 542-6. PMID 22031445 DOI: 10.1038/Nature10503  0.616
2011 Tran TH, Krishnamoorthy K, Begley TP, Ealick SE. A novel mechanism of sulfur transfer catalyzed by O-acetylhomoserine sulfhydrylase in the methionine-biosynthetic pathway of Wolinella succinogenes. Acta Crystallographica. Section D, Biological Crystallography. 67: 831-8. PMID 21931214 DOI: 10.1107/S0907444911028010  0.507
2011 French JB, Begley TP, Ealick SE. Structure of trifunctional THI20 from yeast. Acta Crystallographica. Section D, Biological Crystallography. 67: 784-91. PMID 21904031 DOI: 10.1107/S0907444911024814  0.697
2011 Se?kut? J, McCloskey DE, Thomas HJ, Secrist JA, Pegg AE, Ealick SE. Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine. Protein Science : a Publication of the Protein Society. 20: 1836-44. PMID 21898642 DOI: 10.1002/Pro.717  0.461
2011 French JB, Ealick SE. Structural and kinetic insights into the mechanism of 5-hydroxyisourate hydrolase from Klebsiella pneumoniae. Acta Crystallographica. Section D, Biological Crystallography. 67: 671-7. PMID 21795808 DOI: 10.1107/S090744491101746X  0.701
2011 Mukherjee T, Hanes J, Tews I, Ealick SE, Begley TP. Pyridoxal phosphate: biosynthesis and catabolism. Biochimica Et Biophysica Acta. 1814: 1585-96. PMID 21767669 DOI: 10.1016/J.Bbapap.2011.06.018  0.335
2011 Tran TH, Christoffersen S, Allan PW, Parker WB, Piskur J, Serra I, Terreni M, Ealick SE. The crystal structure of Streptococcus pyogenes uridine phosphorylase reveals a distinct subfamily of nucleoside phosphorylases. Biochemistry. 50: 6549-58. PMID 21707079 DOI: 10.1021/Bi200707Z  0.526
2011 Macheroux P, Kappes B, Ealick SE. Flavogenomics--a genomic and structural view of flavin-dependent proteins. The Febs Journal. 278: 2625-34. PMID 21635694 DOI: 10.1111/j.1742-4658.2011.08202.x  0.408
2011 French JB, Neau DB, Ealick SE. Characterization of the structure and function of Klebsiella pneumoniae allantoin racemase. Journal of Molecular Biology. 410: 447-60. PMID 21616082 DOI: 10.1016/J.Jmb.2011.05.016  0.709
2011 Hazra AB, Han Y, Chatterjee A, Zhang Y, Lai RY, Ealick SE, Begley TP. A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase. Journal of the American Chemical Society. 133: 9311-9. PMID 21534620 DOI: 10.1021/Ja1110514  0.522
2011 French JB, Yates PA, Soysa DR, Boitz JM, Carter NS, Chang B, Ullman B, Ealick SE. The Leishmania donovani UMP synthase is essential for promastigote viability and has an unusual tetrameric structure that exhibits substrate-controlled oligomerization. The Journal of Biological Chemistry. 286: 20930-41. PMID 21507942 DOI: 10.1074/Jbc.M111.228213  0.719
2011 Fenwick MK, Philmus B, Begley TP, Ealick SE. Toxoflavin lyase requires a novel 1-His-2-carboxylate facial triad. Biochemistry. 50: 1091-100. PMID 21166463 DOI: 10.1021/Bi101741V  0.496
2011 Hanes JW, Chatterjee D, Soriano EV, Ealick SE, Begley TP. Construction of a thiamin sensor from the periplasmic thiamin binding protein. Chemical Communications (Cambridge, England). 47: 2273-5. PMID 21125117 DOI: 10.1039/C0Cc04228E  0.76
2011 Zhu X, Dzikovski B, Su X, Torelli AT, Zhang Y, Ealick SE, Freed JH, Lin H. Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis. Molecular Biosystems. 7: 74-81. PMID 20931132 DOI: 10.1039/C0Mb00076K  0.405
2011 Zhang Y, Zhu X, Torelli AT, Lee M, Dzikovski B, Koralewski RM, Wang E, Freed J, Krebs C, Ealick SE, Lin H. Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme (Nature (2010) 465 (891-896)) Nature. 473: 544. DOI: 10.1038/Nature10087  0.326
2011 Kourinov I, Ealick SE, Capel M, Banerjee S, Murphy F, Neau D, Perry K, Rajashankar K, Schuermann J, Sukumar N. NE-CAT crystallography beamlines for challenging structural biology research Acta Crystallographica Section a Foundations of Crystallography. 67: C482-C483. DOI: 10.1016/J.Bpj.2017.11.2864  0.317
2010 Woodward JB, Abeydeera ND, Paul D, Phillips K, Rapala-Kozik M, Freeling M, Begley TP, Ealick SE, McSteen P, Scanlon MJ. A maize thiamine auxotroph is defective in shoot meristem maintenance. The Plant Cell. 22: 3305-17. PMID 20971897 DOI: 10.1105/Tpc.110.077776  0.542
2010 Paul D, Chatterjee A, Begley TP, Ealick SE. Domain organization in Candida glabrata THI6, a bifunctional enzyme required for thiamin biosynthesis in eukaryotes. Biochemistry. 49: 9922-34. PMID 20968298 DOI: 10.1021/Bi101008U  0.7
2010 Bale S, Rajashankar KR, Perry K, Begley TP, Ealick SE. HMP binding protein ThiY and HMP-P synthase THI5 are structural homologues. Biochemistry. 49: 8929-36. PMID 20873853 DOI: 10.1021/Bi101209T  0.672
2010 French JB, Cen Y, Sauve AA, Ealick SE. High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes . Biochemistry. 49: 8803-12. PMID 20853856 DOI: 10.1021/Bi1012436  0.721
2010 French JB, Ealick SE. Structural and mechanistic studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. The Journal of Biological Chemistry. 285: 35446-54. PMID 20826786 DOI: 10.1074/Jbc.M110.156034  0.703
2010 French JB, Ealick SE. Biochemical and structural characterization of a ureidoglycine aminotransferase in the Klebsiella pneumoniae uric acid catabolic pathway. Biochemistry. 49: 5975-7. PMID 20565126 DOI: 10.1021/Bi1006755  0.624
2010 Zhang Y, Zhu X, Torelli AT, Lee M, Dzikovski B, Koralewski RM, Wang E, Freed J, Krebs C, Ealick SE, Lin H. Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. Nature. 465: 891-6. PMID 20559380 DOI: 10.1038/Nature09138  0.315
2010 Paul D, O'Leary SE, Rajashankar K, Bu W, Toms A, Settembre EC, Sanders JM, Begley TP, Ealick SE. Glycal formation in crystals of uridine phosphorylase. Biochemistry. 49: 3499-509. PMID 20364833 DOI: 10.1021/Bi902073B  0.808
2010 Cook WJ, Galakatos N, Boyar WC, Walter RL, Ealick SE. Structure of human desArg-C5a. Acta Crystallographica. Section D, Biological Crystallography. 66: 190-7. PMID 20124699 DOI: 10.1107/S0907444909049051  0.377
2010 Bale S, Baba K, McCloskey DE, Pegg AE, Ealick SE. Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity. Acta Crystallographica. Section D, Biological Crystallography. 66: 181-9. PMID 20124698 DOI: 10.1107/S090744490904877X  0.686
2010 Kang YN, Zhang Y, Allan PW, Parker WB, Ting JW, Chang CY, Ealick SE. Structure of grouper iridovirus purine nucleoside phosphorylase. Acta Crystallographica. Section D, Biological Crystallography. 66: 155-62. PMID 20124695 DOI: 10.1107/S0907444909048276  0.506
2010 McCulloch KM, Mukherjee T, Begley TP, Ealick SE. Structure determination and characterization of the vitamin B6 degradative enzyme (E)-2-(acetamidomethylene)succinate hydrolase. Biochemistry. 49: 1226-35. PMID 20099871 DOI: 10.1021/Bi901812P  0.756
2010 Bale S, Ealick SE. Structural biology of S-adenosylmethionine decarboxylase. Amino Acids. 38: 451-60. PMID 19997761 DOI: 10.1007/S00726-009-0404-Y  0.699
2010 Mukherjee T, McCulloch KM, Ealick SE, Begley TP. Cofactor catabolism Comprehensive Natural Products Ii: Chemistry and Biology. 7: 649-674.  0.714
2009 Jurgenson CT, Ealick SE, Begley TP. Biosynthesis of Thiamin Pyrophosphate. Ecosal Plus. 3. PMID 26443755 DOI: 10.1128/ecosalplus.3.6.3.7  0.831
2009 Sukumar N, Mathews FS, Gordon MM, Ealick SE, Alpers DH. Postcrystallization Analysis of the Irreproducibility of the Human Intrinsic Factor-Cobalamin Complex Crystals. Crystal Growth & Design. 9: 348-351. PMID 19884970 DOI: 10.1021/Cg800509F  0.317
2009 Bale S, Brooks W, Hanes JW, Mahesan AM, Guida WC, Ealick SE. Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase. Biochemistry. 48: 6423-30. PMID 19527050 DOI: 10.1021/Bi900590M  0.651
2009 Jurgenson CT, Begley TP, Ealick SE. The structural and biochemical foundations of thiamin biosynthesis. Annual Review of Biochemistry. 78: 569-603. PMID 19348578 DOI: 10.1146/Annurev.Biochem.78.072407.102340  0.822
2009 McCulloch KM, Mukherjee T, Begley TP, Ealick SE. Structure of the PLP degradative enzyme 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti MAFF303099 and its mechanistic implications. Biochemistry. 48: 4139-49. PMID 19317437 DOI: 10.1021/Bi900149F  0.781
2009 O'Leary SE, Hicks KA, Ealick SE, Begley TP. Biochemical characterization of the HpxO enzyme from Klebsiella pneumoniae, a novel FAD-dependent urate oxidase. Biochemistry. 48: 3033-5. PMID 19260710 DOI: 10.1021/Bi900160B  0.467
2009 McCloskey DE, Bale S, Secrist JA, Tiwari A, Moss TH, Valiyaveettil J, Brooks WH, Guida WC, Pegg AE, Ealick SE. New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine. Journal of Medicinal Chemistry. 52: 1388-407. PMID 19209891 DOI: 10.1021/Jm801126A  0.666
2008 Bale S, Lopez MM, Makhatadze GI, Fang Q, Pegg AE, Ealick SE. Structural basis for putrescine activation of human S-adenosylmethionine decarboxylase. Biochemistry. 47: 13404-17. PMID 19053272 DOI: 10.1021/Bi801732M  0.665
2008 Chatterjee A, Li Y, Zhang Y, Grove TL, Lee M, Krebs C, Booker SJ, Begley TP, Ealick SE. Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily. Nature Chemical Biology. 4: 758-65. PMID 18953358 DOI: 10.1038/Nchembio.121  0.408
2008 O'Leary SE, Jurgenson CT, Ealick SE, Begley TP. O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis. Biochemistry. 47: 11606-15. PMID 18842002 DOI: 10.1021/Bi8013664  0.804
2008 Jurgenson CT, Burns KE, Begley TP, Ealick SE. Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis. Biochemistry. 47: 10354-64. PMID 18771296 DOI: 10.1021/Bi800915J  0.835
2008 Zhang Y, Morar M, Ealick SE. Structural biology of the purine biosynthetic pathway. Cellular and Molecular Life Sciences : Cmls. 65: 3699-724. PMID 18712276 DOI: 10.1007/S00018-008-8295-8  0.745
2008 Chatterjee A, Schroeder FC, Jurgenson CT, Ealick SE, Begley TP. Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate. Journal of the American Chemical Society. 130: 11394-8. PMID 18652458 DOI: 10.1021/Ja802140A  0.811
2008 Morar M, Hoskins AA, Stubbe J, Ealick SE. Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation. Biochemistry. 47: 7816-30. PMID 18597481 DOI: 10.1021/Bi800329P  0.736
2008 Soriano EV, McCloskey DE, Kinsland C, Pegg AE, Ealick SE. Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii. Acta Crystallographica. Section D, Biological Crystallography. 64: 377-82. PMID 18391404 DOI: 10.1107/S0907444908000474  0.81
2008 Müller IB, Knöckel J, Groves MR, Jordanova R, Ealick SE, Walter RD, Wrenger C. The assembly of the plasmodial PLP synthase complex follows a defined course. Plos One. 3: e1815. PMID 18350152 DOI: 10.1371/Journal.Pone.0001815  0.451
2008 McCulloch KM, Kinsland C, Begley TP, Ealick SE. Structural studies of thiamin monophosphate kinase in complex with substrates and products. Biochemistry. 47: 3810-21. PMID 18311927 DOI: 10.1021/Bi800041H  0.779
2008 Soriano EV, Rajashankar KR, Hanes JW, Bale S, Begley TP, Ealick SE. Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor. Biochemistry. 47: 1346-57. PMID 18177053 DOI: 10.1021/Bi7018282  0.814
2008 Zhang Y, White RH, Ealick SE. Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry. 47: 205-17. PMID 18069798 DOI: 10.1021/Bi701406G  0.533
2008 Jenkins AL, Zhang Y, Ealick SE, Begley TP. Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis. Bioorganic Chemistry. 36: 29-32. PMID 18054064 DOI: 10.1016/J.Bioorg.2007.10.005  0.538
2007 Soriano EV, Clark VC, Ealick SE. Structures of human deoxycytidine kinase product complexes. Acta Crystallographica. Section D, Biological Crystallography. 63: 1201-7. PMID 18084067 DOI: 10.1107/S0907444907048834  0.808
2007 Mukherjee T, McCulloch KM, Ealick SE, Begley TP. Gene identification and structural characterization of the pyridoxal 5'-phosphate degradative protein 3-hydroxy-2-methylpyridine-4,5-dicarboxylate decarboxylase from mesorhizobium loti MAFF303099. Biochemistry. 46: 13606-15. PMID 17973403 DOI: 10.1021/Bi701439J  0.78
2007 Mathews FS, Gordon MM, Chen Z, Rajashankar KR, Ealick SE, Alpers DH, Sukumar N. Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 104: 17311-6. PMID 17954916 DOI: 10.1073/Pnas.0703228104  0.368
2007 Pradeep L, Kurinov I, Ealick SE, Scheraga HA. Implementation of a k/k(0) method to identify long-range structure in transition states during conformational folding/unfolding of proteins. Structure (London, England : 1993). 15: 1178-89. PMID 17937908 DOI: 10.1016/J.Str.2007.08.003  0.36
2007 Morar M, White RH, Ealick SE. Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids. Biochemistry. 46: 10562-71. PMID 17713928 DOI: 10.1021/Bi700934V  0.758
2007 Kang YN, Tran A, White RH, Ealick SE. A novel function for the N-terminal nucleophile hydrolase fold demonstrated by the structure of an archaeal inosine monophosphate cyclohydrolase. Biochemistry. 46: 5050-62. PMID 17407260 DOI: 10.1021/Bi061637J  0.542
2007 Hanes JW, Ealick SE, Begley TP. Thiamin phosphate synthase: the rate of pyrimidine carbocation formation. Journal of the American Chemical Society. 129: 4860-1. PMID 17388590 DOI: 10.1021/Ja0679634  0.414
2007 Chatterjee A, Jurgenson CT, Schroeder FC, Ealick SE, Begley TP. Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate. Journal of the American Chemical Society. 129: 2914-22. PMID 17309261 DOI: 10.1021/Ja067606T  0.816
2007 Hoskins AA, Morar M, Kappock TJ, Mathews II, Zaugg JB, Barder TE, Peng P, Okamoto A, Ealick SE, Stubbe J. N5-CAIR mutase: role of a CO2 binding site and substrate movement in catalysis. Biochemistry. 46: 2842-55. PMID 17298082 DOI: 10.1021/Bi602436G  0.722
2007 Zhang Y, El Kouni MH, Ealick SE. Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase. Acta Crystallographica. Section D, Biological Crystallography. 63: 126-34. PMID 17242506 DOI: 10.1107/S0907444906043654  0.483
2007 Zhang Y, Kang SA, Mukherjee T, Bale S, Crane BR, Begley TP, Ealick SE. Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis. Biochemistry. 46: 145-55. PMID 17198384 DOI: 10.1021/Bi0620095  0.716
2006 Allan AL, Gladstone PL, Price ML, Hopkins SA, Juarez JC, Doñate F, Ternansky RJ, Shaw DE, Ganem B, Li Y, Wang W, Ealick S. Synthesis and evaluation of multisubstrate bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase. Journal of Medicinal Chemistry. 49: 7807-15. PMID 17181163 DOI: 10.1021/Jm060428U  0.359
2006 Morar M, Anand R, Hoskins AA, Stubbe J, Ealick SE. Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily. Biochemistry. 45: 14880-95. PMID 17154526 DOI: 10.1021/Bi061591U  0.834
2006 Zein F, Zhang Y, Kang YN, Burns K, Begley TP, Ealick SE. Structural insights into the mechanism of the PLP synthase holoenzyme from Thermotoga maritima. Biochemistry. 45: 14609-20. PMID 17144654 DOI: 10.1021/Bi061464Y  0.534
2006 Jurgenson CT, Chatterjee A, Begley TP, Ealick SE. Structural insights into the function of the thiamin biosynthetic enzyme Thi4 from Saccharomyces cerevisiae. Biochemistry. 45: 11061-70. PMID 16964967 DOI: 10.1021/Bi061025Z  0.852
2006 Chatterjee A, Jurgenson CT, Schroeder FC, Ealick SE, Begley TP. Thiamin biosynthesis in eukaryotes: characterization of the enzyme-bound product of thiazole synthase from Saccharomyces cerevisiae and its implications in thiazole biosynthesis. Journal of the American Chemical Society. 128: 7158-9. PMID 16734458 DOI: 10.1021/Ja061413O  0.824
2006 Xu G, Narayan M, Kurinov I, Ripoll DR, Welker E, Khalili M, Ealick SE, Scheraga HA. A localized specific interaction alters the unfolding pathways of structural homologues. Journal of the American Chemical Society. 128: 1204-13. PMID 16433537 DOI: 10.1021/Ja055313E  0.408
2006 Zhang Y, El Kouni MH, Ealick SE. Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolution. Acta Crystallographica. Section D, Biological Crystallography. 62: 140-5. PMID 16421444 DOI: 10.1107/S090744490503430X  0.466
2006 Zhang Y, Secrist JA, Ealick SE. The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. Acta Crystallographica. Section D, Biological Crystallography. 62: 133-9. PMID 16421443 DOI: 10.1107/S0907444905034293  0.47
2006 Zhang Y, Porcelli M, Cacciapuoti G, Ealick SE. The crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase II from Sulfolobus solfataricus, a thermophilic enzyme stabilized by intramolecular disulfide bonds. Journal of Molecular Biology. 357: 252-62. PMID 16414070 DOI: 10.1016/J.Jmb.2005.12.040  0.518
2006 Lehmann C, Begley TP, Ealick SE. Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis. Biochemistry. 45: 11-9. PMID 16388576 DOI: 10.1021/Bi051502Y  0.498
2005 Dontsova MV, Gabdoulkhakov AG, Molchan OK, Lashkov AA, Garber MB, Mironov AS, Zhukhlistova NE, Morgunova EY, Voelter W, Betzel C, Zhang Y, Ealick SE, Mikhailov AM. Preliminary investigation of the three-dimensional structure of Salmonella typhimurium uridine phosphorylase in the crystalline state. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 337-40. PMID 16511035 DOI: 10.1107/S1744309105007463  0.459
2005 Toms AV, Wang W, Li Y, Ganem B, Ealick SE. Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase. Acta Crystallographica. Section D, Biological Crystallography. 61: 1449-58. PMID 16239721 DOI: 10.1107/S0907444905025503  0.44
2005 Bu W, Settembre EC, el Kouni MH, Ealick SE. Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines. Acta Crystallographica. Section D, Biological Crystallography. 61: 863-72. PMID 15983408 DOI: 10.1107/S0907444905007882  0.778
2005 Zhang Y, Colabroy KL, Begley TP, Ealick SE. Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase: the catalytic mechanism of a complex oxidation involved in NAD biosynthesis. Biochemistry. 44: 7632-43. PMID 15909978 DOI: 10.1021/Bi047353L  0.495
2005 Colabroy KL, Zhai H, Li T, Ge Y, Zhang Y, Liu A, Ealick SE, McLafferty FW, Begley TP. The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate. Biochemistry. 44: 7623-31. PMID 15909977 DOI: 10.1021/Bi0473455  0.425
2005 Zang Y, Wang WH, Wu SW, Ealick SE, Wang CC. Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex. The Journal of Biological Chemistry. 280: 22318-25. PMID 15817485 DOI: 10.1074/Jbc.M501843200  0.384
2005 Toms AV, Haas AL, Park JH, Begley TP, Ealick SE. Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry. 44: 2319-29. PMID 15709744 DOI: 10.1021/Bi0478648  0.56
2005 Dessanti P, Zhang Y, Sgarrella F, Allegrini S, Tozzi MG, Ealick SE. Crystal structures ofBacillus cereusAdoP complexed with substrates Acta Crystallographica Section a Foundations of Crystallography. 61: c204-c204. DOI: 10.1107/S0108767305091324  0.416
2005 Morar M, Anand R, Ealick SE. Study of substrate-complexed formylglycinamide ribonucleotide amidotransferase Acta Crystallographica Section a Foundations of Crystallography. 61: c204-c204. DOI: 10.1107/S0108767305091300  0.777
2005 Zhang Y, Colabroy KL, Begley TP, Ealick SE. Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase Acta Crystallographica Section a Foundations of Crystallography. 61: c205-c205. DOI: 10.1107/S0108767305091282  0.401
2005 Anand R, Hoskins AA, Stubbe JA, Ealick SE. Stucture ofS. typhimuriumformylglycinamide ribonucleotide amidotransferase Acta Crystallographica Section a Foundations of Crystallography. 61: c205-c205. DOI: 10.1107/S0108767305091270  0.63
2005 Soriano E, Settembre E, Begley TP, Ealick SE. Structural studies of quinolinate synthase Acta Crystallographica Section a Foundations of Crystallography. 61: c251-c251. DOI: 10.1107/S0108767305089300  0.804
2004 Zhang Y, Dougherty M, Downs DM, Ealick SE. Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily. Structure (London, England : 1993). 12: 1809-21. PMID 15458630 DOI: 10.1016/J.Str.2004.07.020  0.423
2004 Begley TP, Ealick SE. Enzymatic reactions involving novel mechanisms of carbanion stabilization. Current Opinion in Chemical Biology. 8: 508-15. PMID 15450493 DOI: 10.1016/J.Cbpa.2004.08.004  0.381
2004 Settembre EC, Chittuluru JR, Mill CP, Kappock TJ, Ealick SE. Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE). Acta Crystallographica. Section D, Biological Crystallography. 60: 1753-60. PMID 15388921 DOI: 10.1107/S090744490401858X  0.751
2004 Settembre EC, Dorrestein PC, Zhai H, Chatterjee A, McLafferty FW, Begley TP, Ealick SE. Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex. Biochemistry. 43: 11647-57. PMID 15362849 DOI: 10.1021/Bi0488911  0.793
2004 Wang J, Ealick SE. Observation of time-resolved structural changes by linear interpolation of highly redundant X-ray diffraction data. Acta Crystallographica. Section D, Biological Crystallography. 60: 1579-85. PMID 15333928 DOI: 10.1107/S0907444904016786  0.32
2004 Sahin B, Kansy JW, Nairn AC, Spychala J, Ealick SE, Fienberg AA, Greene RW, Bibb JA. Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation. European Journal of Biochemistry / Febs. 271: 3547-55. PMID 15317590 DOI: 10.1111/J.1432-1033.2004.04291.X  0.345
2004 Anand R, Hoskins AA, Bennett EM, Sintchak MD, Stubbe J, Ealick SE. A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex. Biochemistry. 43: 10343-52. PMID 15301532 DOI: 10.1021/Bi0491292  0.81
2004 Anand R, Hoskins AA, Stubbe J, Ealick SE. Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography. Biochemistry. 43: 10328-42. PMID 15301531 DOI: 10.1021/Bi0491301  0.728
2004 Hoskins AA, Anand R, Ealick SE, Stubbe J. The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation. Biochemistry. 43: 10314-27. PMID 15301530 DOI: 10.1021/Bi049127H  0.706
2004 Zhang Y, Cottet SE, Ealick SE. Structure of Escherichia coli AMP nucleosidase reveals similarity to nucleoside phosphorylases. Structure (London, England : 1993). 12: 1383-94. PMID 15296732 DOI: 10.1016/J.Str.2004.05.015  0.509
2004 Toms AV, Kinsland C, McCloskey DE, Pegg AE, Ealick SE. Evolutionary links as revealed by the structure of Thermotoga maritima S-adenosylmethionine decarboxylase. The Journal of Biological Chemistry. 279: 33837-46. PMID 15150268 DOI: 10.1074/Jbc.M403369200  0.55
2004 Lee JE, Settembre EC, Cornell KA, Riscoe MK, Sufrin JR, Ealick SE, Howell PL. Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design. Biochemistry. 43: 5159-69. PMID 15122881 DOI: 10.1021/Bi035492H  0.763
2004 Dontsova MV, Savochkina YA, Gabdoulkhakov AG, Baidakov SN, Lyashenko AV, Zolotukhina M, Errais Lopes L, Garber MB, Morgunova EY, Nikonov SV, Mironov AS, Ealick SE, Mikhailov A'. Purification, crystallization and preliminary X-ray analysis of uridine phosphorylase from Salmonella typhimurium. Acta Crystallographica. Section D, Biological Crystallography. 60: 709-11. PMID 15039561 DOI: 10.1107/S0907444904001519  0.379
2004 Anand R, Kaminski PA, Ealick SE. Structures of purine 2'-deoxyribosyltransferase, substrate complexes, and the ribosylated enzyme intermediate at 2.0 A resolution. Biochemistry. 43: 2384-93. PMID 14992575 DOI: 10.1021/Bi035723K  0.738
2004 Bauer JA, Bennett EM, Begley TP, Ealick SE. Three-dimensional structure of YaaE from Bacillus subtilis, a glutaminase implicated in pyridoxal-5'-phosphate biosynthesis. The Journal of Biological Chemistry. 279: 2704-11. PMID 14585832 DOI: 10.1074/Jbc.M310311200  0.764
2003 Bennett EM, Anand R, Allan PW, Hassan AE, Hong JS, Levasseur DN, McPherson DT, Parker WB, Secrist JA, Sorscher EJ, Townes TM, Waud WR, Ealick SE. Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system. Chemistry & Biology. 10: 1173-81. PMID 14700625 DOI: 10.1016/J.Chembiol.2003.11.008  0.748
2003 Settembre E, Begley TP, Ealick SE. Structural biology of enzymes of the thiamin biosynthesis pathway. Current Opinion in Structural Biology. 13: 739-47. PMID 14675553 DOI: 10.1016/J.Sbi.2003.10.006  0.74
2003 Manoj N, Ealick SE. Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase. Acta Crystallographica. Section D, Biological Crystallography. 59: 1762-6. PMID 14501115 DOI: 10.1107/S0907444903016214  0.308
2003 Bennett EM, Li C, Allan PW, Parker WB, Ealick SE. Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase. The Journal of Biological Chemistry. 278: 47110-8. PMID 12937174 DOI: 10.1074/Jbc.M304622200  0.752
2003 Manoj N, Strauss E, Begley TP, Ealick SE. Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. Structure (London, England : 1993). 11: 927-36. PMID 12906824 DOI: 10.1016/S0969-2126(03)00146-1  0.518
2003 Settembre EC, Dorrestein PC, Park JH, Augustine AM, Begley TP, Ealick SE. Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis. Biochemistry. 42: 2971-81. PMID 12627963 DOI: 10.1021/Bi026916V  0.782
2003 Tolbert WD, Graham DE, White RH, Ealick SE. Pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii: crystal structures of the self-cleaved and S53A proenzyme forms. Structure (London, England : 1993). 11: 285-94. PMID 12623016 DOI: 10.1016/S0969-2126(03)00026-1  0.497
2003 Tolbert WD, Zhang Y, Cottet SE, Bennett EM, Ekstrom JL, Pegg AE, Ealick SE. Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant. Biochemistry. 42: 2386-95. PMID 12600205 DOI: 10.1021/Bi0268854  0.687
2002 Bennett EM, Ekstrom JL, Pegg AE, Ealick SE. Monomeric S-adenosylmethionine decarboxylase from plants provides an alternative to putrescine stimulation. Biochemistry. 41: 14509-17. PMID 12463749 DOI: 10.1021/Bi026710U  0.705
2002 Anand R, Dorrestein PC, Kinsland C, Begley TP, Ealick SE. Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 A resolution. Biochemistry. 41: 7659-69. PMID 12056897 DOI: 10.1021/Bi0200965  0.71
2002 Cook WJ, Zell A, Watt DD, Ealick SE. Structure of variant 2 scorpion toxin from Centruroides sculpturatus Ewing. Protein Science : a Publication of the Protein Society. 11: 479-86. PMID 11847271 DOI: 10.1110/Ps.39202  0.392
2002 Cheng G, Bennett EM, Begley TP, Ealick SE. Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution. Structure (London, England : 1993). 10: 225-35. PMID 11839308 DOI: 10.1016/S0969-2126(02)00708-6  0.663
2002 Pugmire MJ, Ealick SE. Structural analyses reveal two distinct families of nucleoside phosphorylases. The Biochemical Journal. 361: 1-25. PMID 11743878 DOI: 10.1042/0264-6021:3610001  0.317
2001 Ekstrom JL, Tolbert WD, Xiong H, Pegg AE, Ealick SE. Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant. Biochemistry. 40: 9495-504. PMID 11583148 DOI: 10.1021/bi010736o  0.308
2001 Tolbert WD, Ekstrom JL, Mathews II, Secrist JA, Kapoor P, Pegg AE, Ealick SE. The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase. Biochemistry. 40: 9484-94. PMID 11583147 DOI: 10.1021/Bi010735W  0.487
2001 Peapus DH, Chiu HJ, Campobasso N, Reddick JJ, Begley TP, Ealick SE. Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase. Biochemistry. 40: 10103-14. PMID 11513589 DOI: 10.1021/Bi0104726  0.547
2001 Appleby TC, Mathews II, Porcelli M, Cacciapuoti G, Ealick SE. Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus. The Journal of Biological Chemistry. 276: 39232-42. PMID 11489901 DOI: 10.1074/Jbc.M105694200  0.787
2001 Ni Y, McPhie P, Deacon A, Ealick S, Coleman WG. Evidence that NADP+ Is the Physiological Cofactor of ADP-L-glycero-D-mannoheptose 6-Epimerase Journal of Biological Chemistry. 276: 27329-27334. PMID 11313358 DOI: 10.1074/jbc.M102258200  0.34
2000 Begley TP, Appleby TC, Ealick SE. The structural basis for the remarkable catalytic proficiency of orotidine 5'-monophosphate decarboxylase. Current Opinion in Structural Biology. 10: 711-8. PMID 11114509 DOI: 10.1016/S0959-440X(00)00148-2  0.762
2000 Kappock TJ, Ealick SE, Stubbe J. Modular evolution of the purine biosynthetic pathway. Current Opinion in Chemical Biology. 4: 567-72. PMID 11006546 DOI: 10.1016/S1367-5931(00)00133-2  0.404
2000 Thiel DJ, le Du MH, Walter RL, D'Arcy A, Chène C, Fountoulakis M, Garotta G, Winkler FK, Ealick SE. Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure (London, England : 1993). 8: 927-36. PMID 10986460 DOI: 10.1016/S0969-2126(00)00184-2  0.326
2000 Deacon AM, Ni YS, Coleman WG, Ealick SE. The crystal structure of ADP-L-glycero-D-mannoheptose 6-epimerase: catalysis with a twist. Structure (London, England : 1993). 8: 453-62. PMID 10896473 DOI: 10.1016/S0969-2126(00)00128-3  0.474
2000 Campobasso N, Mathews II, Begley TP, Ealick SE. Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 A resolution. Biochemistry. 39: 7868-77. PMID 10891066 DOI: 10.1021/Bi0000061  0.52
2000 Schumacher MA, Scott DM, Mathews II, Ealick SE, Roos DS, Ullman B, Brennan RG. Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. Journal of Molecular Biology. 298: 875-93. PMID 10801355 DOI: 10.1006/Jmbi.2000.3753  0.387
2000 Appleby TC, Kinsland C, Begley TP, Ealick SE. The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase. Proceedings of the National Academy of Sciences of the United States of America. 97: 2005-10. PMID 10681442 DOI: 10.1073/Pnas.259441296  0.748
2000 Schumacher MA, Scott DM, Mathews II, Ealick SE, Roos DS, Ullman B, Brennan RG. Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. Journal of Molecular Biology. 296: 549-67. PMID 10669608 DOI: 10.1006/Jmbi.1999.3474  0.487
1999 Mathews II, Kappock TJ, Stubbe J, Ealick SE. Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway. Structure (London, England : 1993). 7: 1395-406. PMID 10574791 DOI: 10.1016/S0969-2126(00)80029-5  0.526
1999 Li C, Kappock TJ, Stubbe J, Weaver TM, Ealick SE. X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution. Structure (London, England : 1993). 7: 1155-66. PMID 10508786 DOI: 10.1016/S0969-2126(99)80182-8  0.541
1999 Mueller EJ, Oh S, Kavalerchik E, Kappock TJ, Meyer E, Li C, Ealick SE, Stubbe J. Investigation of the ATP binding site of Escherichia coli aminoimidazole ribonucleotide synthetase using affinity labeling and site-directed mutagenesis. Biochemistry. 38: 9831-9. PMID 10433689 DOI: 10.1021/bi990638r  0.535
1999 Appleby TC, Erion MD, Ealick SE. The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 A resolution provides insights into substrate binding and catalysis. Structure (London, England : 1993). 7: 629-41. PMID 10404592 DOI: 10.1016/S0969-2126(99)80084-7  0.783
1999 Ekstrom JL, Mathews II, Stanley BA, Pegg AE, Ealick SE. The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 A resolution reveals a novel fold. Structure (London, England : 1993). 7: 583-95. PMID 10378277 DOI: 10.1016/S0969-2126(99)80074-4  0.441
1999 Chiu HJ, Reddick JJ, Begley TP, Ealick SE. Crystal structure of thiamin phosphate synthase from Bacillus subtilis at 1.25 A resolution. Biochemistry. 38: 6460-70. PMID 10350464 DOI: 10.1021/Bi982903Z  0.481
1999 Ding L, Zhang Y, Deacon AM, Ealick SE, Ni Y, Sun P, Coleman WG. Crystallization and preliminary X-ray diffraction studies of the lipopolysaccharide core biosynthetic enzyme ADP-L-glycero-D-mannoheptose 6-epimerase from Escherichia coli K-12. Acta Crystallographica. Section D, Biological Crystallography. 55: 685-8. PMID 10089470 DOI: 10.1107/S0907444998014723  0.343
1999 Zhou M, Pugmire MJ, Vuong BQ, Ealick SE. Cloning, expression and crystallization of pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus. Acta Crystallographica. Section D, Biological Crystallography. 55: 287-90. PMID 10089427 DOI: 10.1107/S090744499800852X  0.345
1999 Weaver TM, Wang W, Ealick SE. Purification, crystallization and preliminary X-ray diffraction data from selenomethionine glycinamide ribonucleotide synthetase. Acta Crystallographica. Section D, Biological Crystallography. 55: 518-21. PMID 10089364 DOI: 10.1107/S0907444998009020  0.319
1998 Deacon AM, Appleby T, Bilderback DH, Ealick SE, Fontes E, Thiel DJ. Protein crystallography using a multilayer monochromator. Journal of Synchrotron Radiation. 5: 494-6. PMID 15263556 DOI: 10.1107/S0909049597017275  0.675
1998 Campobasso N, Costello CA, Kinsland C, Begley TP, Ealick SE. Crystal structure of thiaminase-I from Bacillus thiaminolyticus at 2.0 A resolution. Biochemistry. 37: 15981-9. PMID 9843405 DOI: 10.1021/Bi981673L  0.524
1998 Wang W, Kappock TJ, Stubbe J, Ealick SE. X-ray crystal structure of glycinamide ribonucleotide synthetase from Escherichia coli. Biochemistry. 37: 15647-62. PMID 9843369 DOI: 10.1021/Bi981405N  0.498
1998 Mathews II, Erion MD, Ealick SE. Structure of human adenosine kinase at 1.5 A resolution. Biochemistry. 37: 15607-20. PMID 9843365 DOI: 10.1021/bi9815445  0.378
1998 Pugmire MJ, Ealick SE. The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation. Structure (London, England : 1993). 6: 1467-79. PMID 9817849 DOI: 10.1016/S0969-2126(98)00145-2  0.511
1998 Ealick SE. Challenges facing structural biology beamlines Nature Structural Biology. 5: 620-623. PMID 9699607 DOI: 10.1038/1314  0.316
1998 Pugmire MJ, Cook WJ, Jasanoff A, Walter MR, Ealick SE. Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase. Journal of Molecular Biology. 281: 285-99. PMID 9698549 DOI: 10.1006/Jmbi.1998.1941  0.445
1998 Deacon AM, Weeks CM, Miller R, Ealick SE. The Shake-and-Bake structure determination of triclinic lysozyme Proceedings of the National Academy of Sciences of the United States of America. 95: 9284-9289. PMID 9689072 DOI: 10.1073/Pnas.95.16.9284  0.343
1998 Vora RA, Pegg AE, Ealick SE. A new model for how O6-methylguanine-DNA methyltransferase binds DNA Proteins: Structure, Function and Genetics. 32: 3-6. PMID 9672037 DOI: 10.1002/(Sici)1097-0134(19980701)32:1<3::Aid-Prot2>3.0.Co;2-O  0.323
1998 Mao C, Cook WJ, Zhou M, Federov AA, Almo SC, Ealick SE. Calf spleen purine nucleoside phosphorylase complexed with substrates and substrate analogues Biochemistry. 37: 7135-7146. PMID 9585525 DOI: 10.1021/Bi9723919  0.536
1997 Narayana SV, Bugg CE, Ealick SE. Refined structure of purine nucleoside phosphorylase at 2.75 A resolution. Acta Crystallographica. Section D, Biological Crystallography. 53: 131-42. PMID 15299947 DOI: 10.1107/S0907444996012619  0.534
1997 Smith GD, Blessing RH, Ealick SE, Fontecilla-Camps JC, Hauptman HA, Housset D, Langs DA, Miller R. Ab initio structure determination and refinement of a scorpion protein toxin. Acta Crystallographica. Section D, Biological Crystallography. 53: 551-7. PMID 15299886 DOI: 10.1107/S0907444997005386  0.34
1997 Mao C, Cook WJ, Zhou M, Koszalka GW, Krenitsky TA, Ealick SE. The crystal structure of Escherichia coli purine nucleoside phosphorylase: A comparison with the human enzyme reveals a conserved topology Structure. 5: 1373-1383. PMID 9351810  0.392
1997 Erion MD, Stoeckler JD, Guida WC, Walter RL, Ealick SE. Purine nucleoside phosphorylase. 2. Catalytic mechanism Biochemistry. 36: 11735-11748. PMID 9305963 DOI: 10.1021/Bi961970V  0.329
1997 Erion MD, Takabayashi K, Smith HB, Kessi J, Wagner S, Hönger S, Shames SL, Ealick SE. Purine nucleoside phosphorylase. 1. Structure-function studies. Biochemistry. 36: 11725-34. PMID 9305962 DOI: 10.1021/bi961969w  0.302
1996 Walter RL, Ealick SE, Friedman AM, Blake RC, Proctor P, Shoham M. Multiple wavelength anomalous diffraction (MAD) crystal structure of rusticyanin: a highly oxidizing cupredoxin with extreme acid stability. Journal of Molecular Biology. 263: 730-51. PMID 8947572 DOI: 10.1006/Jmbi.1996.0612  0.432
1996 Armstrong SR, Cook WJ, Short SA, Ealick SE. Crystal structures of nucleoside 2-deoxyribosyltransferase in native and ligand-bound forms reveal architecture of the active site Structure. 4: 97-107. PMID 8805514 DOI: 10.1016/S0969-2126(96)00013-5  0.555
1996 Short SA, Armstrong SR, Ealick SE, Porter DJ. Active site amino acids that participate in the catalytic mechanism of nucleoside 2'-deoxyribosyltransferase. The Journal of Biological Chemistry. 271: 4978-87. PMID 8617773 DOI: 10.1074/Jbc.271.9.4978  0.46
1996 Mikhailov AM, Morgunoya EY, Ealick SE, Mao C, Armstrong SR, Mironov AS, Komissarov AA. The X-ray structure of uridine phosphorylase fromE. coliat 2.5 Å resolution Acta Crystallographica Section a Foundations of Crystallography. 52: C108-C108. DOI: 10.1107/S0108767396094846  0.304
1996 Thiel D, le Du M, Walter R, D'Arcy A, Chene C, Fontoulakis M, Garotta G, Winkler F, Ealick S. Three-dimensional structure of human interferon-γ complexed to its cell receptor Acta Crystallographica Section a Foundations of Crystallography. 52: C184-C184. DOI: 10.1107/S0108767396091933  0.301
1995 Morgunova EY, Mikhailov AM, Popov AN, Blagova EV, Smirnova EA, Vainshtein BK, Mao C, Armstrong SR, Ealick SE, Komissarov AA, Linkova EV, Burlakova AA, Mironov AS, Debabov VG. Atomic structure at 2.5 Å resolution of uridine phosphorylase from E. coli as refined in the monoclinic crystal lattice Febs Letters. 367: 183-187. PMID 7796917 DOI: 10.1016/0014-5793(95)00489-V  0.374
1995 Deacon A, Habash J, Harrop SJ, Helliwell JR, Hunter WN, Leonard GA, Peterson M, Hadener A, Kalb (Gilboa) AJ, Allinson NM, Castelli C, Moon K, McSweeney S, Gonzalez A, Thompson AW, ... Ealick S, et al. SR instrumentation for optimized anomalous scattering and high resolution structure studies of proteins and nucleic acids (invited) Review of Scientific Instruments. 66: 1287-1292. DOI: 10.1063/1.1145956  0.324
1994 Walter RL, Symersky J, Poirot AF, Stoeckler JD, Erion MD, Ealick SE. X-ray crystallographic and kinetic analysis of human purine nucleoside phosphorylase complexes with 1-β-D-ribofuranosyl-1,2,4-triazole-3- carboxamide and 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine Nucleosides and Nucleotides. 13: 689-706. DOI: 10.1080/15257779408013273  0.328
1993 Secrist JA, Niwas S, Rose JD, Babu YS, Bugg CE, Erion MD, Guida WC, Ealick SE, Montgomery JA. Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine. Journal of Medicinal Chemistry. 36: 1847-54. PMID 8515423 DOI: 10.1021/Jm00065A007  0.343
1993 Montgomery JA, Niwas S, Rose JD, Secrist JA, Babu YS, Bugg CE, Erion MD, Guida WC, Ealick SE. Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine. Journal of Medicinal Chemistry. 36: 55-69. PMID 8421291 DOI: 10.1021/Jm00053A008  0.339
1993 Murgolo NJ, Windsor WT, Hruza A, Reichert P, Tsarbopoulos A, Baldwin S, Huang E, Pramanik B, Ealick S, Trotta PP. A homology model of human interferon α-2 Proteins: Structure, Function and Genetics. 17: 62-74. PMID 8234245 DOI: 10.1002/Prot.340170109  0.351
1993 Bugg CE, Ealick SE, Montgomery JA, Secrist JA, Babu YS, Erion MD, Guida WC. The structure of human purine nucleoside phosphorylase and its use in inhibitor design Acta Crystallographica Section a Foundations of Crystallography. 49: c157-c157. DOI: 10.1107/S0108767378095513  0.315
1992 Zhao B, Carson M, Ealick SE, Bugg CE. Structure of scorpion toxin variant-3 at 1.2 A resolution. Journal of Molecular Biology. 227: 239-52. PMID 1522588 DOI: 10.1016/0022-2836(92)90694-F  0.362
1992 Otter BA, Patil SA, Klein RS, Ealick SE. A corrected structure for pyrrolosine Journal of the American Chemical Society. 114: 668-671. DOI: 10.1021/Ja00028A038  0.363
1990 Walter MR, Cook WJ, Cole LB, Short SA, Koszalka GW, Krenitsky TA, Ealick SE. Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution. The Journal of Biological Chemistry. 265: 14016-22. PMID 2199449 DOI: 10.2210/Pdb1Tpt/Pdb  0.376
1985 EALICK SE, GREENHOUGH TJ, BABU YS, CARTER DC, COOK WJ, BUGG CE, RULE SA, HABASH J, HELLIWELL JR, STOECKLER JD, CHEN SF, PARKS RE. Three-Dimensional Structure of Human Erythrocytic Purine Nucleoside Phosphorylasea Annals of the New York Academy of Sciences. 451: 311-312. DOI: 10.1111/J.1749-6632.1985.Tb27124.X  0.339
1984 Ealick SE, Greenhough TJ, Sudhakar-Babu Y, Cook WJ, Bugg CE, Rule S, Habash G, Helliwell J. The crystal structure of human erythrocytic purine nucleoside phosphorylase at 6 Å resolution Acta Crystallographica Section a Foundations of Crystallography. 40: C30-C30. DOI: 10.1107/S0108767384098895  0.343
1981 Ealick SE, Almassy RJ, Fontecilla JC, Suddath FL, Bugg CE. The crystal and molecular structure of neurotoxins from scorpion venom Acta Crystallographica Section a Foundations of Crystallography. 37: C23-C23. DOI: 10.1107/S0108767381098899  0.346
1981 Fontecilla-Camps JC, Almassy RJ, Ealick SE, Suddath F, Watt DD, Feldmann RJ, Bugg CE. Architecture of scorpion neurotoxins: a class of membrane-binding proteins Trends in Biochemical Sciences. 6: 291-296. DOI: 10.1016/0968-0004(81)90105-5  0.396
1977 Ramalingam K, Thyvelikakath GX, Berlin KD, Chesnut RW, Brown RA, Durham NN, Ealick SE, van der Helm D. Synthesis and biological activity of some derivatives of thiochroman-4-one and tetrahydrothiapyran-4-one. Journal of Medicinal Chemistry. 20: 847-50. PMID 406397 DOI: 10.1002/Chin.197742193  0.484
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