Year |
Citation |
Score |
2023 |
Zhao Y, Yao Z, Ren W, Yang X, Hou X, Cao S, Fang H. Design, synthesis and bioactivity evaluations of 8-substituted-quinoline-2-carboxamide derivatives as novel histone deacetylase (HDAC) inhibitors. Bioorganic & Medicinal Chemistry. 85: 117242. PMID 37079967 DOI: 10.1016/j.bmc.2023.117242 |
0.317 |
|
2022 |
Liang H, Zhu Y, Zhao Z, Du J, Yang X, Fang H, Hou X. Structure-Based Design of 2-Aminopurine Derivatives as CDK2 Inhibitors for Triple-Negative Breast Cancer. Frontiers in Pharmacology. 13: 864342. PMID 35592410 DOI: 10.3389/fphar.2022.864342 |
0.313 |
|
2022 |
Liang X, Li X, Zhao Z, Nie Y, Yao Z, Ren W, Yang X, Hou X, Fang H. Design, synthesis and biological evaluation of hydantoin derivatives as Mcl-1 selective inhibitors. Bioorganic Chemistry. 121: 105643. PMID 35150958 DOI: 10.1016/j.bioorg.2022.105643 |
0.326 |
|
2021 |
Liang T, Xue J, Yao Z, Ye Y, Yang X, Hou X, Fang H. Design, synthesis and biological evaluation of 3, 4-disubstituted-imidazolidine-2, 5-dione derivatives as HDAC6 selective inhibitors. European Journal of Medicinal Chemistry. 221: 113526. PMID 33992929 DOI: 10.1016/j.ejmech.2021.113526 |
0.343 |
|
2020 |
Zhou Y, Liu X, Xue J, Liu L, Liang T, Li W, Yang X, Hou X, Fang H. Discovery of Peptide Boronate Derivatives as Histone Deacetylase (HDAC) and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma. Journal of Medicinal Chemistry. PMID 32267687 DOI: 10.1021/Acs.Jmedchem.9B02161 |
0.316 |
|
2020 |
Liu L, Liu R, Yang X, Hou X, Fang H. Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. European Journal of Medicinal Chemistry. 191: 112142. PMID 32088497 DOI: 10.1016/J.Ejmech.2020.112142 |
0.437 |
|
2019 |
Chen C, Yang X, Fang H, Hou X. Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors. European Journal of Medicinal Chemistry. 181: 111563. PMID 31415980 DOI: 10.1016/J.Ejmech.2019.111563 |
0.312 |
|
2019 |
Liang T, Hou X, Zhou Y, Yang X, Fang H. Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors. Acs Medicinal Chemistry Letters. 10: 1122-1127. PMID 31413795 DOI: 10.1021/Acsmedchemlett.9B00084 |
0.414 |
|
2019 |
Chen C, Nie Y, Xu G, Yang X, Fang H, Hou X. Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors. Bioorganic & Medicinal Chemistry. PMID 31079964 DOI: 10.1016/J.Bmc.2019.05.003 |
0.386 |
|
2019 |
Liu R, Liu L, Yang X, Fang H. Discovery and development of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as Bcl-2/Mcl-1 inhibitors. Bioorganic Chemistry. 88: 102938. PMID 31028992 DOI: 10.1016/J.Bioorg.2019.102938 |
0.429 |
|
2019 |
Li Y, Fang H, Hou Z, Sang L, Yang X. An in-line capillary electrophoresis assay for the high-throughput screening of histone deacetylase inhibitors. Journal of Chromatography. A. PMID 30665742 DOI: 10.1016/J.Chroma.2019.01.025 |
0.328 |
|
2018 |
Liu R, Liu L, Liu T, Yang X, Wan Y, Fang H. Discovery and development of substituted tyrosine derivatives as Bcl-2/Mcl-1 inhibitors. Bioorganic & Medicinal Chemistry. PMID 30170927 DOI: 10.1016/J.Bmc.2018.08.030 |
0.393 |
|
2017 |
Xu G, Liu T, Zhou Y, Yang X, Fang H. 1-Phenyl-1H-indole derivatives as a new class of Bcl-2/Mcl-1 dual inhibitors: Design, synthesis, and preliminary biological evaluation. Bioorganic & Medicinal Chemistry. PMID 28866374 DOI: 10.1016/J.Bmc.2017.08.024 |
0.407 |
|
2017 |
Su R, Hou Z, Sang L, Zhou ZM, Fang H, Yang X. Enantioseparation of angiotensin II receptor type 1 blockers: evaluation of 6-substituted carbamoyl benzimidazoles on immobilized polysaccharide-based chiral stationary phases. Unusual temperature behavior. Journal of Chromatography. A. PMID 28784322 DOI: 10.1016/J.Chroma.2017.07.081 |
0.312 |
|
2017 |
Zhou Y, Dun Y, Fu H, Wang L, Pan X, Yang X, Fang H. Design, synthesis and preliminary bioactivity evaluation of N-benzylpyrimidin-2-amine derivatives as novel histone deacetylase (HDAC) inhibitor. Chemical Biology & Drug Design. PMID 28489276 DOI: 10.1111/Cbdd.13019 |
0.405 |
|
2017 |
Chen C, Hou X, Wang G, Pan W, Yang X, Zhang Y, Fang H. Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors. European Journal of Medicinal Chemistry. 133: 11-23. PMID 28371677 DOI: 10.1016/J.Ejmech.2017.03.064 |
0.403 |
|
2015 |
Fu H, Hou X, Wang L, Dun Y, Yang X, Fang H. Design, synthesis and biological evaluation of 3-aryl-rhodanine benzoic acids as anti-apoptotic protein Bcl-2 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 26421995 DOI: 10.1016/J.Bmcl.2015.09.051 |
0.411 |
|
2015 |
Yan Y, Chen X, Yang X, Zhang J, Xu W, Zhang Y. Synthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase. Bioorganic & Medicinal Chemistry. PMID 26386821 DOI: 10.1016/J.Bmc.2015.09.013 |
0.358 |
|
2015 |
Wan Y, Wu S, Xiao G, Liu T, Hou X, Chen C, Guan P, Yang X, Fang H. Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors. Bioorganic & Medicinal Chemistry. 23: 1994-2003. PMID 25818766 DOI: 10.1016/J.Bmc.2015.03.024 |
0.41 |
|
2014 |
Chen D, Shen A, Li J, Shi F, Chen W, Ren J, Liu H, Xu Y, Wang X, Yang X, Sun Y, Yang M, He J, Wang Y, Zhang L, et al. Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. European Journal of Medicinal Chemistry. 87: 765-81. PMID 25313505 DOI: 10.1016/j.ejmech.2014.09.065 |
0.303 |
|
2014 |
Yang X, Su L, Hou X, Ding S, Xu W, Wang B, Fang H. High-performance liquid chromatographic enantioseparation of 3,5-disubstituted hydantoins analogs and temperature-induced reversals of elution orders on a polysaccharide-based chiral stationary phase. Journal of Chromatography. A. 1355: 291-5. PMID 24973033 DOI: 10.1016/J.Chroma.2014.06.022 |
0.459 |
|
2012 |
Yang X, Hou X, Wang B, Li M, Fang H. Density functional theory based quantitative structure-property relationship studies on coumarin-based prodrugs. Bioscience Trends. 6: 234-40. PMID 23229116 DOI: 10.5582/Bst.2012.V6.5.234 |
0.427 |
|
2012 |
Wu Z, Yang X, Xu W, Wang B, Fang H. A new boronic acid-based fluorescent sensor for L-dihydroxyphenylalanine. Drug Discoveries and Therapeutics. 6: 238-241. DOI: 10.5582/Ddt.2012.V6.5.238 |
0.425 |
|
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