☰

Thomas Kukar, Ph.D. - Publications

Affiliations: 
School of Medicine Emory University, Atlanta, GA 
Area:
Neurodegeneration
Website:
http://www.pharm.emory.edu/tkukar/
Tree Info Grants Similar researchers PubMed Report error

26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 McEachin ZT, Gendron TF, Raj N, García-Murias M, Banerjee A, Purcell RH, Ward PJ, Todd TW, Merritt-Garza ME, Jansen-West K, Hales CM, García-Sobrino T, Quintáns B, Holler CJ, Taylor G, ... ... Kukar T, et al. Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36. Neuron. PMID 32375063 DOI: 10.1016/J.Neuron.2020.04.011  0.331
2018 Chou CC, Zhang Y, Umoh ME, Vaughan SW, Lorenzini I, Liu F, Sayegh M, Donlin-Asp PG, Chen YH, Duong DM, Seyfried NT, Powers MA, Kukar T, Hales CM, Gearing M, et al. TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD. Nature Neuroscience. PMID 29311743 DOI: 10.1038/S41593-017-0047-3  0.327
2017 Moore BD, Martin J, de Mena L, Sanchez J, Cruz PE, Ceballos-Diaz C, Ladd TB, Ran Y, Levites Y, Kukar TL, Kurian JJ, McKenna R, Koo EH, Borchelt DR, Janus C, et al. Short Aβ peptides attenuate Aβ42 toxicity in vivo. The Journal of Experimental Medicine. PMID 29208777 DOI: 10.1084/Jem.20170600  0.574
2016 Holler CJ, Taylor G, McEachin ZT, Deng Q, Watkins WJ, Hudson K, Easley CA, Hu WT, Hales CM, Rossoll W, Bassell GJ, Kukar T. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia. Molecular Neurodegeneration. 11: 46. PMID 27341800 DOI: 10.1186/S13024-016-0114-3  0.336
2014 Jung JI, Ran Y, Cruz PE, Rosario AM, Ladd TB, Kukar TL, Koo EH, Felsenstein KM, Golde TE. Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators. Biochemistry. 53: 1947-57. PMID 24620716 DOI: 10.1021/Bi401521T  0.582
2013 Jung JI, Ladd TB, Kukar T, Price AR, Moore BD, Koo EH, Golde TE, Felsenstein KM. Steroids as γ-secretase modulators. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 3775-85. PMID 23716494 DOI: 10.1096/Fj.12-225649  0.556
2012 Verbeeck C, Deng Q, Dejesus-Hernandez M, Taylor G, Ceballos-Diaz C, Kocerha J, Golde T, Das P, Rademakers R, Dickson DW, Kukar T. Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis. Molecular Neurodegeneration. 7: 53. PMID 23046583 DOI: 10.1186/1750-1326-7-53  0.505
2012 Das P, Verbeeck C, Minter L, Chakrabarty P, Felsenstein K, Kukar T, Maharvi G, Fauq A, Osborne BA, Golde TE. Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology. Molecular Neurodegeneration. 7: 39. PMID 22892055 DOI: 10.1186/1750-1326-7-39  0.535
2012 Moore BD, Chakrabarty P, Levites Y, Kukar TL, Baine AM, Moroni T, Ladd TB, Das P, Dickson DW, Golde TE. Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains. Alzheimer's Research & Therapy. 4: 18. PMID 22621179 DOI: 10.1186/Alzrt121  0.567
2011 Sagi SA, Lessard CB, Winden KD, Maruyama H, Koo JC, Weggen S, Kukar TL, Golde TE, Koo EH. Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein. The Journal of Biological Chemistry. 286: 39794-803. PMID 21868380 DOI: 10.1074/Jbc.M111.277228  0.536
2011 Kukar TL, Ladd TB, Robertson P, Pintchovski SA, Moore B, Bann MA, Ren Z, Jansen-West K, Malphrus K, Eggert S, Maruyama H, Cottrell BA, Das P, Basi GS, Koo EH, et al. Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region. The Journal of Biological Chemistry. 286: 39804-12. PMID 21868378 DOI: 10.1074/Jbc.M111.274696  0.593
2010 Kukar T, Ladd T, Robertson P, Moore B, Jansen-West K, Eggert S, Koo E, Golde T. O2-03-01: Insight into the mechanism of gamma-secretase cleavage: Juxtamembrane amino acids are key to the length of secreted amyloid beta peptide Alzheimer's & Dementia. 6: S100-S100. DOI: 10.1016/J.Jalz.2010.05.314  0.556
2009 Sala Frigerio C, Kukar TL, Fauq A, Engel PC, Golde TE, Walsh DM. An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1. Biochemistry. 48: 10894-904. PMID 19821615 DOI: 10.1021/Bi901237K  0.584
2009 Golde TE, Kukar TL. Medicine. Avoiding unintended toxicity. Science (New York, N.Y.). 324: 603-4. PMID 19407192 DOI: 10.1126/science.1174267  0.378
2008 Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, et al. Substrate-targeting gamma-secretase modulators. Nature. 453: 925-9. PMID 18548070 DOI: 10.1038/Nature07055  0.71
2008 Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. The Journal of Biological Chemistry. 283: 17049-54. PMID 18426795 DOI: 10.1074/Jbc.M802912200  0.647
2008 Kukar T, Golde TE. Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage. Current Topics in Medicinal Chemistry. 8: 47-53. PMID 18220932 DOI: 10.2174/156802608783334042  0.636
2008 Schmidt B, Baumann S, Hoettecke N, Narlawar R, Kukar T, Golde TE, Baumann K. IC-P3-212: Mapping the binding site of gamma-secretase modulators by small (and not so small) organic molecules Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.157  0.452
2008 Kukar TL, Ladd TB, Bann MA, Fraering PC, Maharvi GM, Moore B, Rangachari V, Welzel A, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, et al. P2-338: Substrate-targeting gamma-secretase modulators Alzheimer's & Dementia. 4: T472-T472. DOI: 10.1016/J.Jalz.2008.05.1415  0.429
2007 Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM. Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. Bmc Neuroscience. 8: 54. PMID 17650315 DOI: 10.1186/1471-2202-8-54  0.705
2006 Nyborg AC, Ladd TB, Jansen K, Kukar T, Golde TE. Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1671-9. PMID 16873890 DOI: 10.1096/Fj.06-5762Com  0.508
2006 Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S. Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. Journal of Neurochemistry. 96: 355-65. PMID 16300630 DOI: 10.1111/J.1471-4159.2005.03553.X  0.639
2006 Kukar T, Ladd T, Bann M, Fraering P, Kache R, Fauq A, Wolfe M, Koo EH, Golde TE. P4-289: Mechanistic insights into the in vitro and in vivo modulation of Aβ42 levels and amyloid pathology by NSAIDS and related compounds Alzheimer's & Dementia. 2: S601-S602. DOI: 10.1016/J.Jalz.2006.05.2028  0.584
2005 Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, et al. Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nature Medicine. 11: 545-50. PMID 15834426 DOI: 10.1038/Nm1235  0.73
2004 Kukar T. P4-323 Compounds that raise Aβ42 provide insight into the mechanism of gamma-secretase cleavage modulation Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81881-5  0.405
2004 Golde TE, Eriksen J, Nicolle M, Murphy MP, Kukar T, Monnier T, Prescott S, Wright S, Chevallier N, Sagi S, Das P, Koo EH. O3-06-02 Selective Abeta42 modifying agents: effects on Abeta deposition and behavior in TG2576 mice Neurobiology of Aging. 25: S64. DOI: 10.1016/S0197-4580(04)80215-X  0.693
Show low-probability matches.