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Vishva M. Dixit - Publications

Affiliations: 
Physiological Chemistry Genentech, Inc., San Francisco, CA, United States 
Area:
disease-related cellular signaling
Website:
http://www.gene.com/scientists/our-scientists/vishva-dixit

220 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ndoja A, Reja R, Lee SH, Webster JD, Ngu H, Rose CM, Kirkpatrick DS, Modrusan Z, Chen YJ, Dugger DL, Gandham V, Xie L, Newton K, Dixit VM. Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia. Cell. PMID 32795415 DOI: 10.1016/J.Cell.2020.07.011  0.319
2019 McKenzie BA, Dixit VM, Power C. Fiery Cell Death: Pyroptosis in the Central Nervous System. Trends in Neurosciences. PMID 31843293 DOI: 10.1016/J.Tins.2019.11.005  0.374
2019 Newton K, Wickliffe KE, Maltzman A, Dugger DL, Reja R, Zhang Y, Roose-Girma M, Modrusan Z, Sagolla MS, Webster JD, Dixit VM. Activity of caspase-8 determines plasticity between cell death pathways. Nature. PMID 31723262 DOI: 10.1038/S41586-019-1752-8  0.393
2019 Kayagaki N, Dixit VM. Rescue from a fiery death: A therapeutic endeavor. Science (New York, N.Y.). 366: 688-689. PMID 31699924 DOI: 10.1126/Science.Aaw1177  0.301
2019 Newton K, Wickliffe KE, Dugger DL, Maltzman A, Roose-Girma M, Dohse M, Kőműves L, Webster JD, Dixit VM. Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature. PMID 31511692 DOI: 10.1038/S41586-019-1548-X  0.414
2019 Zhang J, Webster JD, Dugger DL, Goncharov T, Roose-Girma M, Hung J, Kwon YC, Vucic D, Newton K, Dixit VM. Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation. Cell Reports. 27: 2679-2689.e3. PMID 31141691 DOI: 10.1016/J.Celrep.2019.04.111  0.429
2019 Kayagaki N, Lee BL, Stowe IB, Kornfeld OS, O'Rourke K, Mirrashidi KM, Haley B, Watanabe C, Roose-Girma M, Modrusan Z, Kummerfeld S, Reja R, Zhang Y, Cho V, Andrews TD, ... ... Dixit VM, et al. IRF2 transcriptionally induces expression for pyroptosis. Science Signaling. 12. PMID 31113851 DOI: 10.1126/Scisignal.Aax4917  0.39
2019 He M, Chaurushiya MS, Webster JD, Kummerfeld S, Reja R, Chaudhuri S, Chen YJ, Modrusan Z, Haley B, Dugger DL, Eastham-Anderson J, Lau S, Dey A, Caothien R, Roose-Girma M, ... ... Dixit VM, et al. Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science (New York, N.Y.). 364: 283-285. PMID 31000662 DOI: 10.1126/Science.Aav4902  0.336
2019 Abed M, Verschueren E, Budayeva H, Liu P, Kirkpatrick DS, Reja R, Kummerfeld SK, Webster JD, Gierke S, Reichelt M, Anderson KR, Newman RJ, Roose-Girma M, Modrusan Z, Pektas H, ... ... Dixit VM, et al. The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification. Plos One. 14: e0214110. PMID 30951545 DOI: 10.1371/Journal.Pone.0214110  0.324
2018 Heger K, Dixit VM. TBK1 and IKKε restrain cell death. Nature Cell Biology. 20: 1330-1331. PMID 30482939 DOI: 10.1038/S41556-018-0239-4  0.395
2018 Newton K, Dugger DL, Sengupta-Ghosh A, Ferrando RE, Chu F, Tao J, Lam W, Haller S, Chan S, Sa S, Dunlap D, Eastham-Anderson J, Ngu H, Hung J, French DM, ... ... Dixit VM, et al. Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain. Proceedings of the National Academy of Sciences of the United States of America. PMID 30322923 DOI: 10.1073/Pnas.1805033115  0.317
2018 Heger K, Wickliffe KE, Ndoja A, Zhang J, Murthy A, Dugger DL, Maltzman A, de Sousa E Melo F, Hung J, Zeng Y, Verschueren E, Kirkpatrick DS, Vucic D, Lee WP, Roose-Girma M, ... ... Dixit VM, et al. OTULIN limits cell death and inflammation by deubiquitinating LUBAC. Nature. PMID 29950720 DOI: 10.1038/S41586-018-0256-2  0.434
2018 Huang CS, Oberbeck N, Hsiao YC, Liu P, Johnson AR, Dixit VM, Hymowitz SG. Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity. Structure (London, England : 1993). PMID 29706531 DOI: 10.1016/J.Str.2018.04.002  0.348
2018 Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, ... ... Dixit VM, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. PMID 29362479 DOI: 10.1038/S41418-017-0012-4  0.366
2017 Zhang Z, Newton K, Kummerfeld SK, Webster J, Kirkpatrick DS, Phu L, Eastham-Anderson J, Liu J, Lee WP, Wu J, Li H, Junttila MR, Dixit VM. Transcription factor Etv5 is essential for the maintenance of alveolar type II cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 28351980 DOI: 10.1073/Pnas.1621177114  0.318
2016 Newton K, Wickliffe KE, Maltzman A, Dugger DL, Strasser A, Pham VC, Lill JR, Roose-Girma M, Warming S, Solon M, Ngu H, Webster JD, Dixit VM. RIPK1 inhibits ZBP1-driven necroptosis during development. Nature. PMID 27819682 DOI: 10.1038/Nature20559  0.392
2016 Aglietti RA, Estevez A, Gupta A, Ramirez MG, Liu PS, Kayagaki N, Ciferri C, Dixit VM, Dueber EC. GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes. Proceedings of the National Academy of Sciences of the United States of America. PMID 27339137 DOI: 10.1073/Pnas.1607769113  0.309
2016 Broz P, Dixit VM. Inflammasomes: mechanism of assembly, regulation and signalling. Nature Reviews. Immunology. PMID 27291964 DOI: 10.1038/Nri.2016.58  0.354
2016 Qu Y, Misaghi S, Newton K, Maltzman A, Izrael-Tomasevic A, Arnott D, Dixit VM. NLRP3 recruitment by NLRC4 during Salmonella infection. The Journal of Experimental Medicine. PMID 27139490 DOI: 10.1084/Jem.20132234  0.412
2016 Naik E, Dixit VM. Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity. Journal of Immunology (Baltimore, Md. : 1950). PMID 26936881 DOI: 10.4049/Jimmunol.1403165  0.364
2015 Heaton SM, Borg NA, Dixit VM. Ubiquitin in the activation and attenuation of innate antiviral immunity. The Journal of Experimental Medicine. PMID 26712804 DOI: 10.1084/Jem.20151531  0.352
2015 Wertz IE, Newton K, Seshasayee D, Kusam S, Lam C, Zhang J, Popovych N, Helgason E, Schoeffler A, Jeet S, Ramamoorthi N, Kategaya L, Newman RJ, Horikawa K, Dugger D, ... ... Dixit VM, et al. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature. 528: 370-5. PMID 26649818 DOI: 10.1038/Nature16165  0.35
2015 Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, ... ... Dixit VM, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 526: 666-71. PMID 26375259 DOI: 10.1038/Nature15541  0.383
2015 Rutz S, Kayagaki N, Phung QT, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang OW, Cochran AG, Vasser M, Fauber BP, DeVoss J, Webster J, ... ... Dixit VM, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 518: 417-21. PMID 25470037 DOI: 10.1038/Nature13979  0.322
2015 Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, ... ... Dixit VM, et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation. 22: 58-73. PMID 25236395 DOI: 10.1038/Cdd.2014.137  0.394
2014 Wertz I, Dixit V. A20--a bipartite ubiquitin editing enzyme with immunoregulatory potential Advances in Experimental Medicine and Biology. 809: 1-12. PMID 25302362 DOI: 10.1007/978-1-4939-0398-6_1  0.354
2014 Naik E, Webster JD, DeVoss J, Liu J, Suriben R, Dixit VM. Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X Journal of Experimental Medicine. 211: 1947-1955. PMID 25200027 DOI: 10.1084/Jem.20140860  0.316
2014 Lamkanfi M, Dixit VM. Mechanisms and functions of inflammasomes Cell. 157: 1013-1022. PMID 24855941 DOI: 10.1016/J.Cell.2014.04.007  0.319
2014 Newton K, Hildebrand JM, Shen Z, Rodriguez D, Alvarez-Diaz S, Petersen S, Shah S, Dugger DL, Huang C, Auwerx J, Vandenabeele P, Green DR, Ashkenazi A, Dixit VM, Kaiser WJ, et al. Is SIRT2 required for necroptosis? Nature. 506: E4-6. PMID 24572428 DOI: 10.1038/Nature13024  0.346
2014 Newton K, Dugger DL, Wickliffe KE, Kapoor N, De Almagro MC, Vucic D, Komuves L, Ferrando RE, French DM, Webster J, Roose-Girma M, Warming S, Dixit VM. Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis Science. 343: 1357-1360. PMID 24557836 DOI: 10.1126/Science.1249361  0.431
2013 Rajasekaran K, Kumar P, Schuldt KM, Peterson EJ, Vanhaesebroeck B, Dixit V, Thakar MS, Malarkannan S. Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. Nature Immunology. 14: 1127-36. PMID 24036998 DOI: 10.1038/Ni.2708  0.344
2013 Kayagaki N, Wong MT, Stowe IB, Ramani SR, Gonzalez LC, Akashi-Takamura S, Miyake K, Zhang J, Lee WP, Muszyński A, Forsberg LS, Carlson RW, Dixit VM. Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science (New York, N.Y.). 341: 1246-9. PMID 23887873 DOI: 10.1126/Science.1240248  0.307
2013 Huang X, McGann JC, Liu BY, Hannoush RN, Lill JR, Pham V, Newton K, Kakunda M, Liu J, Yu C, Hymowitz SG, Hongo JA, Wynshaw-Boris A, Polakis P, Harland RM, ... Dixit VM, et al. Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling. Science (New York, N.Y.). 339: 1441-5. PMID 23371553 DOI: 10.1126/Science.1232253  0.352
2012 Lamkanfi M, Dixit VM. Inflammasomes and their roles in health and disease Annual Review of Cell and Developmental Biology. 28: 137-161. PMID 22974247 DOI: 10.1146/Annurev-Cellbio-101011-155745  0.359
2012 Broz P, Ruby T, Belhocine K, Bouley DM, Kayagaki N, Dixit VM, Monack DM. Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1 Nature. 490: 288-291. PMID 22895188 DOI: 10.1038/Nature11419  0.424
2012 Qu Y, Misaghi S, Izrael-Tomasevic A, Newton K, Gilmour LL, Lamkanfi M, Louie S, Kayagaki N, Liu J, Kömüves L, Cupp JE, Arnott D, Monack D, Dixit VM. Phosphorylation of NLRC4 is critical for inflammasome activation Nature. 490: 539-542. PMID 22885697 DOI: 10.1038/Nature11429  0.356
2012 Harhaj EW, Dixit VM. Regulation of NF-κB by deubiquitinases Immunological Reviews. 246: 107-124. PMID 22435550 DOI: 10.1111/J.1600-065X.2012.01100.X  0.324
2012 Newton K, Dixit VM. Signaling in innate immunity and inflammation Cold Spring Harbor Perspectives in Biology. 4. PMID 22296764 DOI: 10.1101/Cshperspect.A006049  0.391
2012 Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q, Bosanac I, Arnott D, Dixit VM, Hymowitz SG, Starovasnik MA, Cochran AG. Phosphorylation-dependent activity of the deubiquitinase DUBA Nature Structural and Molecular Biology. 19: 171-176. PMID 22245969 DOI: 10.1038/Nsmb.2206  0.333
2011 Kayagaki N, Warming S, Lamkanfi M, Walle LV, Louie S, Dong J, Newton K, Qu Y, Liu J, Heldens S, Zhang J, Lee WP, Roose-Girma M, Dixit VM. Non-canonical inflammasome activation targets caspase-11 Nature. 479: 117-121. PMID 22002608 DOI: 10.1038/Nature10558  0.397
2011 Williams SA, Maecker HL, French DM, Liu J, Gregg A, Silverstein LB, Cao TC, Carano RAD, Dixit VM. USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma Cell. 146: 918-930. PMID 21925315 DOI: 10.1016/J.Cell.2011.07.040  0.305
2011 Huang XD, Dixit VM. Cross talk between ubiquitination and demethylation Molecular and Cellular Biology. 31: 3682-3683. PMID 21807896 DOI: 10.1128/Mcb.06001-11  0.305
2011 Lamkanfi M, Dixit VM. Modulation of inflammasome pathways by bacterial and viral pathogens Journal of Immunology. 187: 596-602. PMID 21734079 DOI: 10.4049/Jimmunol.1100229  0.34
2011 Vucic D, Dixit VM, Wertz IE. Ubiquitylation in apoptosis: A post-translational modification at the edge of life and death Nature Reviews Molecular Cell Biology. 12: 439-452. PMID 21697901 DOI: 10.1038/Nrm3143  0.405
2011 Huang X, Summers MK, Pham V, Lill JR, Liu J, Lee G, Kirkpatrick DS, Jackson PK, Fang G, Dixit VM. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. Molecular Cell. 42: 511-23. PMID 21596315 DOI: 10.1016/J.Molcel.2011.03.027  0.303
2011 Qu Y, Misaghi S, Newton K, Gilmour LL, Louie S, Cupp JE, Dubyak GR, Hackos D, Dixit VM. Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation Journal of Immunology. 186: 6553-6561. PMID 21508259 DOI: 10.4049/Jimmunol.1100478  0.428
2011 Wertz IE, Kusam S, Lam C, Okamoto T, Sandoval W, Anderson DJ, Helgason E, Ernst JA, Eby M, Liu J, Belmont LD, Kaminker JS, O'Rourke KM, Pujara K, Kohli PB, ... ... Dixit VM, et al. Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature. 471: 110-4. PMID 21368834 DOI: 10.1038/Nature09779  0.365
2011 Harhaj EW, Dixit VM. Deubiquitinases in the regulation of NF-κB signaling Cell Research. 21: 22-39. PMID 21119682 DOI: 10.1038/Cr.2010.166  0.305
2010 Bosanac I, Wertz IE, Pan B, Yu C, Kusam S, Lam C, Phu L, Phung Q, Maurer B, Arnott D, Kirkpatrick DS, Dixit VM, Hymowitz SG. Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling. Molecular Cell. 40: 548-57. PMID 21095585 DOI: 10.1016/J.Molcel.2010.10.009  0.337
2010 Hymowitz SG, Dixit VM. Unleashing cell death: The Fas-FADD complex Nature Structural and Molecular Biology. 17: 1289-1290. PMID 21088666 DOI: 10.1038/Nsmb1110-1289  0.368
2010 Lamkanfi M, Sarkar A, Vande Walle L, Vitari AC, Amer AO, Wewers MD, Tracey KJ, Kanneganti TD, Dixit VM. Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. Journal of Immunology (Baltimore, Md. : 1950). 185: 4385-92. PMID 20802146 DOI: 10.4049/Jimmunol.1000803  0.359
2010 McCoy AJ, Koizumi Y, Toma C, Higa N, Dixit V, Taniguchi S, Tschopp J, Suzuki T. Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages. European Journal of Immunology. 40: 2797-803. PMID 20722078 DOI: 10.1002/Eji.201040490  0.412
2010 Lamkanfi M, Dixit VM. Manipulation of host cell death pathways during microbial infections Cell Host and Microbe. 8: 44-54. PMID 20638641 DOI: 10.1016/J.Chom.2010.06.007  0.338
2010 Broz P, Newton K, Lamkanfi M, Mariathasan S, Dixit VM, Monack DM. Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella Journal of Experimental Medicine. 207: 1745-1755. PMID 20603313 DOI: 10.1084/Jem.20100257  0.359
2010 Misaghi S, Garris CS, Sun Y, Nguyen A, Zhang J, Sebrell A, Senger K, Yan D, Lorenzo MN, Heldens S, Lee WP, Xu M, Wu J, DeForge L, Sai T, ... Dixit VM, et al. Increased targeting of donor switch region and IgE in Sγ1-deficient B cells Journal of Immunology. 185: 166-173. PMID 20511552 DOI: 10.4049/Jimmunol.1000515  0.316
2010 Jones JW, Kayagaki N, Broz P, Henry T, Newton K, O'Rourke K, Chan S, Dong J, Qu Y, Roose-Girma M, Dixit VM, Monack DM. Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis Proceedings of the National Academy of Sciences of the United States of America. 107: 9771-9776. PMID 20457908 DOI: 10.1073/Pnas.1003738107  0.334
2010 Dixit VM. Signalling lessons from death receptors: The importance of cleavage Nature Cell Biology. 12: 415. PMID 20442699 DOI: 10.1038/Ncb0510-415  0.339
2010 Naik E, Dixit VM. Modulation of inflammasome activity for the treatment of auto-inflammatory disorders Journal of Clinical Immunology. 30: 485-490. PMID 20358394 DOI: 10.1007/S10875-010-9383-8  0.357
2010 Wertz IE, Dixit VM. Signaling to NF-kappaB: regulation by ubiquitination. Cold Spring Harbor Perspectives in Biology. 2: a003350. PMID 20300215 DOI: 10.1101/Cshperspect.A003350  0.347
2010 Pereg Y, Liu BY, O'Rourke KM, Sagolla M, Dey A, Komuves L, French DM, Dixit VM. Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A Nature Cell Biology. 12: 400-406. PMID 20228808 DOI: 10.1038/Ncb2041  0.339
2010 Schwickart M, Huang X, Lill JR, Liu J, Ferrando R, French DM, Maecker H, O'Rourke K, Bazan F, Eastham-Anderson J, Yue P, Dornan D, Huang DCS, Dixit VM. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival Nature. 463: 103-107. PMID 20023629 DOI: 10.1038/Nature08646  0.331
2010 Wertz IE, Dixit VM. Regulation of death receptor signaling by the ubiquitin system. Cell Death and Differentiation. 17: 14-24. PMID 19893571 DOI: 10.1038/Cdd.2009.168  0.356
2009 Vucic D, Dixit VM. Masking MALT1: The paracaspase's potential for cancer therapy Journal of Experimental Medicine. 206: 2309-2312. PMID 19841088 DOI: 10.1084/Jem.20092160  0.372
2009 Lamkanfi M, Mueller JL, Vitari AC, Misaghi S, Fedorova A, Deshayes K, Lee WP, Hoffman HM, Dixit VM. Glyburide inhibits the Cryopyrin/Nalp3 inflammasome Journal of Cell Biology. 187: 61-70. PMID 19805629 DOI: 10.1083/Jcb.200903124  0.343
2009 Wilson NS, Dixit V, Ashkenazi A. Death receptor signal transducers: nodes of coordination in immune signaling networks. Nature Immunology. 10: 348-55. PMID 19295631 DOI: 10.1038/Ni.1714  0.353
2009 Misaghi S, Ottosen S, Izrael-Tomasevic A, Arnott D, Lamkanfi M, Lee J, Liu J, O'Rourke K, Dixit VM, Wilson AC. Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1. Molecular and Cellular Biology. 29: 2181-92. PMID 19188440 DOI: 10.1128/Mcb.01517-08  0.362
2009 Lamkanfi M, Dixit VM. Inflammasomes: Guardians of cytosolic sanctity Immunological Reviews. 227: 95-105. PMID 19120479 DOI: 10.1111/J.1600-065X.2008.00730.X  0.401
2009 Kaufmann T, Jost PJ, Pellegrini M, Puthalakath H, Gugasyan R, Gerondakis S, Cretney E, Smyth MJ, Silke J, Hakem R, Bouillet P, Mak TW, Dixit VM, Strasser A. Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim Immunity. 30: 56-66. PMID 19119023 DOI: 10.1016/J.Immuni.2008.10.017  0.399
2008 Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, ... ... Dixit VM, et al. Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell. 134: 668-78. PMID 18724939 DOI: 10.1016/J.Cell.2008.07.039  0.332
2008 Wertz IE, Dixit VM. Ubiquitin-mediated regulation of TNFR1 signaling Cytokine and Growth Factor Reviews. 19: 313-324. PMID 18515172 DOI: 10.1016/J.Cytogfr.2008.04.014  0.34
2008 Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ, Nizet V, Dixit VM, Karin M. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proceedings of the National Academy of Sciences of the United States of America. 105: 7803-8. PMID 18511561 DOI: 10.1073/Pnas.0802726105  0.744
2007 Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, Zobel K, Dynek JN, Elliott LO, Wallweber HJ, Flygare JA, Fairbrother WJ, Deshayes K, Dixit VM, Vucic D. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell. 131: 669-81. PMID 18022362 DOI: 10.1016/J.Cell.2007.10.030  0.439
2007 Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM. DUBA: A deubiquitinase that regulates type I interferon production Science. 318: 1628-1632. PMID 17991829 DOI: 10.1126/Science.1145918  0.346
2007 Kaufmann T, Tai L, Ekert PG, Huang DCS, Norris F, Lindemann RK, Johnstone RW, Dixit VM, Strasser A. The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest Cell. 129: 423-433. PMID 17448999 DOI: 10.1016/J.Cell.2007.03.017  0.357
2006 Varfolomeev E, Wayson SM, Dixit VM, Fairbrother WJ, Vucic D. The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2. The Journal of Biological Chemistry. 281: 29022-9. PMID 16891304 DOI: 10.1074/Jbc.M605116200  0.411
2006 Zamboni DS, Kobayashi KS, Kohlsdorf T, Ogura Y, Long EM, Vance RE, Kuida K, Mariathasan S, Dixit VM, Flavell RA, Dietrich WF, Roy CR. The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nature Immunology. 7: 318-25. PMID 16444259 DOI: 10.1038/Ni1305  0.388
2006 Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature. 440: 228-32. PMID 16407890 DOI: 10.1038/Nature04515  0.364
2005 Zhou H, Monack DM, Kayagaki N, Wertz I, Yin J, Wolf B, Dixit VM. Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation Journal of Experimental Medicine. 202: 1327-1332. PMID 16301742 DOI: 10.1084/Jem.20051194  0.358
2005 Mariathasan S, Weiss DS, Dixit VM, Monack DM. Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. The Journal of Experimental Medicine. 202: 1043-9. PMID 16230474 DOI: 10.1084/Jem.20050977  0.375
2005 Andersen PL, Zhou H, Pastushok L, Moraes T, McKenna S, Ziola B, Ellison MJ, Dixit VM, Xiao W. Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. The Journal of Cell Biology. 170: 745-55. PMID 16129784 DOI: 10.1083/Jcb.200502113  0.321
2005 Zhou H, Du MQ, Dixit VM. Constitutive NF-κB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity Cancer Cell. 7: 425-431. PMID 15894263 DOI: 10.1016/J.Ccr.2005.04.012  0.309
2004 Wartz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling Nature. 430: 694-699. PMID 15258597 DOI: 10.1038/Nature02794  0.379
2004 Mariathasan S, Hewton K, Monack DM, Vucic D, French DM, Lee WP, Roose-Girma M, Erickson S, Dixit VM. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf Nature. 430: 213-218. PMID 15190255 DOI: 10.1038/Nature02664  0.423
2004 Dornan D, Wertz I, Shimizu H, Arnott D, Frantz GD, Dowd P, O'Rourke K, Koeppen H, Dixit VM. The ubiquitin ligase COP1 is a critical negative regulator of p53 Nature. 429: 86-92. PMID 15103385 DOI: 10.1038/Nature02514  0.335
2004 Che T, You Y, Wang D, Tanner MJ, Dixit VM, Lin X. MALT1/Paracaspase Is a Signaling Component Downstream of CARMA1 and Mediates T Cell Receptor-induced NF-κB Activation Journal of Biological Chemistry. 279: 15870-15876. PMID 14754896 DOI: 10.1074/Jbc.M310599200  0.416
2004 Newton K, French DM, Yan M, Frantz GD, Dixit VM. Myodegeneration in EDA-A2 Transgenic Mice Is Prevented by XEDAR Deficiency Molecular and Cellular Biology. 24: 1608-1613. PMID 14749376 DOI: 10.1128/Mcb.24.4.1608-1613.2004  0.646
2004 Newton K, Sun X, Dixit VM. Kinase RIP3 Is Dispensable for Normal NF-κBs, Signaling by the B-Cell and T-Cell Receptors, Tumor Necrosis Factor Receptor 1, and Toll-Like Receptors 2 and 4 Molecular and Cellular Biology. 24: 1464-1469. PMID 14749364 DOI: 10.1128/Mcb.24.4.1464-1469.2004  0.415
2004 Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science (New York, N.Y.). 303: 1371-4. PMID 14739464 DOI: 10.1126/Science.1093549  0.328
2004 Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagir S, Eby M, Xiao W, Dixit VM. Bcl10 activates the NF-κB pathway through ubiquitination of NEMO Nature. 427: 167-171. PMID 14695475 DOI: 10.1038/Nature02273  0.385
2004 Ruefli-Brasse AA, Lee WP, Hurst S, Dixit VM. Rip2 Participates in Bcl10 Signaling and T-cell Receptor-mediated NF-κB Activation Journal of Biological Chemistry. 279: 1570-1574. PMID 14638696 DOI: 10.1074/Jbc.C300460200  0.398
2003 Hymowitz SG, Compaan DM, Yan M, Wallweber HJA, Dixit VM, Starovasnik MA, De Vos AM. The Crystal Structures of EDA-A1 and EDA-A2: Splice Variants with Distinct Receptor Specificity Structure. 11: 1513-1520. PMID 14656435 DOI: 10.1016/J.Str.2003.11.009  0.649
2003 Ruefli-Brasse AA, French DM, Dixit VM. Regulation of NF-κB-Dependent Lymphocyte Activation and Development by Paracaspase Science. 302: 1581-1584. PMID 14576442 DOI: 10.1126/Science.1090769  0.433
2003 Newton K, Dixit VM. Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes Current Biology. 13: 1247-1251. PMID 12867037 DOI: 10.1016/S0960-9822(03)00458-5  0.374
2003 Gordon NC, Pan B, Hymowitz SG, Yin J, Kelley RF, Cochran AG, Yan M, Dixit VM, Fairbrother WJ, Starovasnik MA. BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site. Biochemistry. 42: 5977-83. PMID 12755599 DOI: 10.1021/Bi034017G  0.691
2003 Seshasayee D, Valdez P, Yan M, Dixit VM, Tumas D, Grewal IS. Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor Immunity. 18: 279-288. PMID 12594954 DOI: 10.1016/S1074-7613(03)00025-6  0.705
2002 Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Immunity. 17: 515-24. PMID 12387744 DOI: 10.1016/S1074-7613(02)00425-9  0.702
2002 Yan M, Zhang Z, Brady JR, Schilbach S, Fairbrother WJ, Dixit VM. Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice Current Biology. 12: 409-413. PMID 11882293 DOI: 10.1016/S0960-9822(02)00687-5  0.697
2002 Vucic D, Deshayes K, Ackerly H, Pisabarro MT, Kadkhodayan S, Fairbrother WJ, Dixit VM. SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP) Journal of Biological Chemistry. 277: 12275-12279. PMID 11801603 DOI: 10.1074/Jbc.M112045200  0.434
2002 Sun X, Yin J, Starovasnik MA, Fairbrother WJ, Dixit VM. Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3 Journal of Biological Chemistry. 277: 9505-9511. PMID 11734559 DOI: 10.1074/Jbc.M109488200  0.409
2001 Zhao H, Yan M, Wang H, Erickson S, Grewal IS, Dixit VM. Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice Journal of Experimental Medicine. 194: 1441-1448. PMID 11714751 DOI: 10.1084/Jem.194.10.1441  0.692
2001 Yan M, Brady JR, Chan B, Lee WP, Hsu B, Harless S, Cancro M, Grewal IS, Dixit VM. Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency Current Biology. 11: 1547-1552. PMID 11591325 DOI: 10.1016/S0960-9822(01)00481-X  0.69
2001 Fairbrother WJ, Gordon NC, Humke EW, O'Rourke KM, Starovasnik MA, Yin JP, Dixit VM. The PYRIN domain: a member of the death domain-fold superfamily. Protein Science : a Publication of the Protein Society. 10: 1911-8. PMID 11514682 DOI: 10.1110/Ps.13801  0.746
2001 Yan M, Wang H, Chan B, Roose-Girma M, Erickson S, Baker T, Tumas D, Grewal IS, Dixit VM. Activation and accumulation of B cells in TACI-deficient mice Nature Immunology. 2: 638-643. PMID 11429549 DOI: 10.1038/89790  0.692
2001 Wang H, Marsters SA, Baker T, Chan B, Lee WP, Fu L, Tumas D, Yan M, Dixit VM, Ashkenazi A, Grewal IS. TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice. Nature Immunology. 2: 632-7. PMID 11429548 DOI: 10.1038/89782  0.684
2001 Aravind L, Dixit VM, Koonin EV. Apoptotic molecular machinery: Vastly increased complexity in vertebrates revealed by genome comparisons Science. 291: 1279-1284. PMID 11181990 DOI: 10.1126/Science.291.5507.1279  0.324
2000 Vucic D, Stennicke HR, Pisabarro MT, Salvesen GS, Dixit VM. ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas Current Biology. 10: 1359-1366. PMID 11084335 DOI: 10.1016/S0960-9822(00)00781-8  0.399
2000 Humke EW, Shriver SK, Starovasnik MA, Fairbrother WJ, Dixit VM. ICEBERG: a novel inhibitor of interleukin-1beta generation. Cell. 103: 99-111. PMID 11051551 DOI: 10.1016/S0092-8674(00)00108-2  0.751
2000 Yan M, Wang LC, Hymowitz SG, Schilbach S, Lee J, Goddard A, De Vos AM, Gao WQ, Dixit VM. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors Science. 290: 523-527. PMID 11039935 DOI: 10.1126/Science.290.5491.523  0.66
2000 Strasser A, O'Connor L, Dixit VM. Apoptosis signaling Annual Review of Biochemistry. 69: 217-245. PMID 10966458 DOI: 10.1146/annurev.biochem.69.1.217  0.309
2000 Marsters SA, Yan M, Pitti RM, Haas PE, Dixit VM, Ashkenazi A. Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Current Biology : Cb. 10: 785-8. PMID 10898980 DOI: 10.1016/S0960-9822(00)00566-2  0.699
2000 Yan M, Marsters SA, Grewal IS, Wang H, Ashkenazi A, Dixit VM. Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nature Immunology. 1: 37-41. PMID 10881172 DOI: 10.1038/76889  0.692
2000 Sosinowski T, Pandey A, Dixit VM, Weiss A. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. The Journal of Experimental Medicine. 191: 463-74. PMID 10662792 DOI: 10.1084/Jem.191.3.463  0.519
1999 Seshagiri S, Vucic D, Lee J, Dixit VM. Baculovirus-based genetic screen for antiapoptotic genes identifies a novel IAP Journal of Biological Chemistry. 274: 36769-36773. PMID 10593985 DOI: 10.1074/Jbc.274.51.36769  0.377
1999 Koonin EV, Aravind L, Hofmann K, Tschopp J, Dixit VM. Searching for FLASH domains Nature. 401: 662-663. PMID 10537104 DOI: 10.1038/44317  0.388
1999 Germain M, Affar EB, D'Amours D, Dixit VM, Salvesen GS, Poirier GG. Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. The Journal of Biological Chemistry. 274: 28379-84. PMID 10497198 DOI: 10.1074/Jbc.274.40.28379  0.406
1999 Hofmann K, Dixit VM. Reply to Kolesnick and Hannun, and Perry and Hannun Trends in Biochemical Sciences. 24: 227-227. PMID 10366849 DOI: 10.1016/S0968-0004(99)01410-3  0.359
1999 Xiaoqing S, James L, Navas T, Baldwin DT, Stewart TA, Dixit VM. RIP3, a novel apoptosis-inducing kinase Journal of Biological Chemistry. 274: 16871-16875. PMID 10358032 DOI: 10.1074/Jbc.274.24.16871  0.455
1999 Zhang Q, Siebert R, Yan M, Hinzmann B, Cui X, Xue L, Rakestraw KM, Naeve CW, Beckmann G, Weisenburger DD, Sanger WG, Nowotny H, Vesely M, Callet-Bauchu E, Salles G, ... Dixit VM, et al. Inactivating mutations and overexpression of BCL 10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32) Nature Genetics. 22: 63-68. PMID 10319863 DOI: 10.1038/8767  0.71
1999 Ashkenazi A, Dixit VM. Apoptosis control by death and decoy receptors. Current Opinion in Cell Biology. 11: 255-60. PMID 10209153 DOI: 10.1016/S0955-0674(99)80034-9  0.398
1999 Yan M, Lee J, Schilbach S, Goddard A, Dixit V. mE10, a novel caspase recruitment domain-containing proapoptotic molecule. The Journal of Biological Chemistry. 274: 10287-92. PMID 10187815 DOI: 10.1074/Jbc.274.15.10287  0.714
1999 Aravind L, Dixit VM, Koonin EV. The domains of death: Evolution of the apoptosis machinery Trends in Biochemical Sciences. 24: 47-53. PMID 10098397 DOI: 10.1016/S0968-0004(98)01341-3  0.377
1999 Stennicke HR, Deveraux QL, Humke EW, Reed JC, Dixit VM, Salvesen GS. Caspase-9 can be activated without proteolytic processing. The Journal of Biological Chemistry. 274: 8359-62. PMID 10085063 DOI: 10.1074/Jbc.274.13.8359  0.76
1999 Song Q, Kuang Y, Dixit VM, Vincenz C. Boo, a novel negative regulator of cell death, interacts with Apaf-1 Embo Journal. 18: 167-178. PMID 9878060 DOI: 10.1093/Emboj/18.1.167  0.425
1999 Salvesen GS, Dixit VM. Caspase activation: The induced-proximity model Proceedings of the National Academy of Sciences of the United States of America. 96: 10964-10967. DOI: 10.1073/Pnas.96.20.10964  0.409
1998 Hofmann K, Dixit VM. Ceramide in apoptosis - Does it really matter? Trends in Biochemical Sciences. 23: 374-377. PMID 9810222 DOI: 10.1016/S0968-0004(98)01289-4  0.407
1998 Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. The Journal of Biological Chemistry. 273: 30336-43. PMID 9804796 DOI: 10.1074/Jbc.273.46.30336  0.653
1998 Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM. Caspase-14 is a novel developmentally regulated protease Journal of Biological Chemistry. 273: 29648-29653. PMID 9792675 DOI: 10.1074/Jbc.273.45.29648  0.403
1998 Roche S, Alonso G, Kazlauskas A, Dixit VM, Courtneidge SA, Pandey A. Src-like adaptor protein (Slap) is a negative regulator of mitogenesis. Current Biology : Cb. 8: 975-8. PMID 9742401 DOI: 10.1016/S0960-9822(98)70400-2  0.517
1998 McCarthy JV, Dixit VM. Apoptosis induced by Drosophila reaper and grim in a human system: Attenuation by inhibitor of apoptosis proteins (cIAPs) Journal of Biological Chemistry. 273: 24009-24015. PMID 9727017 DOI: 10.1074/Jbc.273.37.24009  0.431
1998 Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science (New York, N.Y.). 281: 1305-8. PMID 9721089 DOI: 10.1126/Science.281.5381.1305  0.388
1998 Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. Febs Letters. 431: 351-6. PMID 9714541 DOI: 10.1016/S0014-5793(98)00791-1  0.425
1998 Chaudhary D, O'Rourke K, Chinnaiyan AM, Dixit VM. The death inhibitory molecules CED-9 and CED-4L use a common mechanism to inhibit the CED-3 death protease Journal of Biological Chemistry. 273: 17708-17712. PMID 9651369 DOI: 10.1074/Jbc.273.28.17708  0.404
1998 D'Amours D, Germain M, Orth K, Dixit VM, Poirier GG. Proteolysis of poly(ADP-ribose) polymerase by caspase 3: kinetics of cleavage of mono(ADP-ribosyl)ated and DNA-bound substrates. Radiation Research. 150: 3-10. PMID 9650595 DOI: 10.2307/3579638  0.312
1998 McCarthy JV, Ni J, Dixit VM. RIP2 is a novel NF-κB-activating and cell death-inducing kinase Journal of Biological Chemistry. 273: 16968-16975. PMID 9642260 DOI: 10.1074/Jbc.273.27.16968  0.456
1998 Humke EW, Ni J, Dixit VM. ERICE, a novel FLICE-activatable caspase. The Journal of Biological Chemistry. 273: 15702-7. PMID 9624166 DOI: 10.1074/Jbc.273.25.15702  0.774
1998 Pan G, Humke EW, Dixit VM. Activation of caspases triggered by cytochrome c in vitro. Febs Letters. 426: 151-4. PMID 9598997 DOI: 10.1016/S0014-5793(98)00330-5  0.758
1998 Walsh CM, Wen BG, Chinnaiyan AM, O'Rourke K, Dixit VM, Hedrick SM. A role for FADD in T cell activation and development Immunity. 8: 439-449. PMID 9586634 DOI: 10.1016/S1074-7613(00)80549-X  0.408
1998 Gerber HP, Dixit V, Ferrara N. Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells Journal of Biological Chemistry. 273: 13313-13316. PMID 9582377 DOI: 10.1074/Jbc.273.21.13313  0.312
1998 Pan G, Ni J, Yu GL, Wei YF, Dixit VM. TRUNDD, a new member of thr TRAIL receptor family that antagonizes TRAIL signalling Febs Letters. 424: 41-45. PMID 9537512 DOI: 10.1016/S0014-5793(98)00135-5  0.43
1998 Pan G, O'Rourke K, Dixit VM. Caspase-9, Bcl-X(L), and Apaf-1 form a ternary complex Journal of Biological Chemistry. 273: 5841-5845. PMID 9488720 DOI: 10.1074/Jbc.273.10.5841  0.412
1998 Froelich CJ, Dixit VM, Yang X. Lymphocyte granule-mediated apoptosis: Matters of viral mimicry and deadly proteases Immunology Today. 19: 30-36. PMID 9465486 DOI: 10.1016/S0167-5699(97)01184-5  0.429
1998 Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM. An induced proximity model for caspase-8 activation. The Journal of Biological Chemistry. 273: 2926-30. PMID 9446604 DOI: 10.1074/Jbc.273.5.2926  0.439
1998 Pan G, Humke EW, Dixit VM. Corrigendum to: Activation of caspases triggered by cytochrome c in vitro (FEBS 20097) Febs Letters. 428: 309-309. DOI: 10.1016/S0014-5793(98)00465-7  0.743
1997 Salvesen GS, Dixit VM. Caspases: Intracellular signaling by proteolysis Cell. 91: 443-446. PMID 9390553 DOI: 10.1016/S0092-8674(00)80430-4  0.383
1997 Muzio M, Ni J, Feng P, Dixit VM. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL- 1 signaling Science. 278: 1612-1615. PMID 9374458 DOI: 10.1126/Science.278.5343.1612  0.317
1997 Rehemtulla A, Hamilton CA, Chinnaiyan AM, Dixit VM. Ultraviolet radiation-induced apoptosis is mediated by activation of CD- 95 (Fas/APO-1) Journal of Biological Chemistry. 272: 25783-25786. PMID 9325306 DOI: 10.1074/Jbc.272.41.25783  0.366
1997 Chinnaiyan AM, Chaudhary D, O'Rourke K, Koonin EV, Dixit VM. Role of CED-4 in the activation of CED-3 [9] Nature. 388: 728-729. PMID 9285582 DOI: 10.1038/41913  0.438
1997 Pan G, Ni J, Wei YF, Yu GI, Gentz R, Dixit VM. An antagonist decoy receptor and a death domain-containing receptor for TRAIL Science. 277: 815-818. PMID 9242610 DOI: 10.1126/Science.277.5327.815  0.422
1997 Clayton LK, Ghendler Y, Mizoguchi E, Patch RJ, Ocain TD, Orth K, Bhan AK, Dixit VM, Reinherz EL. T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: The molecular basis of negative selection Embo Journal. 16: 2282-2293. PMID 9171343 DOI: 10.1093/Emboj/16.9.2282  0.409
1997 Chinnaiyan AM, Dixit VM. Portrait of an executioner: The molecular mechanism of Fas/APO-1-induced apoptosis Seminars in Immunology. 9: 69-76. PMID 9106309 DOI: 10.1006/Smim.1996.0055  0.425
1997 Hu S, Vincenz C, Buller M, Dixit VM. A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis Journal of Biological Chemistry. 272: 9621-9624. PMID 9092488 DOI: 10.1074/Jbc.272.15.9621  0.413
1997 Orth K, Dixit VM. Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis Journal of Biological Chemistry. 272: 8841-8844. PMID 9082997 DOI: 10.1074/Jbc.272.14.8841  0.407
1997 Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM. The receptor for the cytotoxic ligand TRAIL Science. 276: 111-113. PMID 9082980 DOI: 10.1126/Science.276.5309.111  0.42
1997 Zhou Q, Snipas S, Ortht K, Muzio M, Dixit VM, Salvesen GS. Target protease specificity of the viral serpin CrmA. Analysis of five cascapses Journal of Biological Chemistry. 272: 7797-7800. PMID 9065443 DOI: 10.1074/Jbc.272.12.7797  0.418
1997 Chinnaiyan AM, Woffendin C, Dixit VM, Nabel GJ. The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication Nature Medicine. 3: 333-337. PMID 9055863 DOI: 10.1038/Nm0397-333  0.303
1997 Vincenz C, Dixit VM. Fas-associated death domain protein interleukin-1β-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55- mediated death signaling Journal of Biological Chemistry. 272: 6578-6583. PMID 9045686 DOI: 10.1074/Jbc.272.10.6578  0.395
1997 Chinnaiyan AM, O'Rourke K, Lane BR, Dixit VM. Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death Science. 275: 1122-1126. PMID 9027312 DOI: 10.1126/Science.275.5303.1122  0.389
1997 Muzio M, Salvesen GS, Dixit VM. FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens Journal of Biological Chemistry. 272: 2952-2956. PMID 9006941 DOI: 10.1074/Jbc.272.5.2952  0.443
1997 Duan H, Dixit VM. RAIDD is a new 'death' adaptor molecule Nature. 385: 86-89. PMID 8985253 DOI: 10.1038/385086A0  0.42
1996 Singleton JR, Dixit VM, Feldman EL. Type I insulin-like growth factor receptor activation regulates apoptotic proteins Journal of Biological Chemistry. 271: 31791-31794. PMID 8943217 DOI: 10.1074/Jbc.271.50.31791  0.35
1996 Dixit VM. Role of ice-proteases in apoptosis Advances in Experimental Medicine and Biology. 406: 113-117. PMID 8910676 DOI: 10.1007/978-1-4899-0274-0_11  0.39
1996 Froelich CJ, Orth K, Turbov J, Seth P, Gottlieb R, Babior B, Shah GM, Bleackley RC, Dixit VM, Hanna W. New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. The Journal of Biological Chemistry. 271: 29073-9. PMID 8910561 DOI: 10.1074/Jbc.271.46.29073  0.41
1996 Chinnaiyan AM, O'Rourke K, Yu GL, Lyons RH, Garg M, Duan DR, Xing L, Gentz R, Ni J, Dixit VM. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95 Science. 274: 990-992. PMID 8875942 DOI: 10.1126/Science.274.5289.990  0.425
1996 Chinnaiyan AM, Hanna WL, Orth K, Duan H, Poirier GG, Froelich CJ, Dixit VM. Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3. Current Biology : Cb. 6: 897-9. PMID 8805307 DOI: 10.1016/S0960-9822(02)00614-0  0.391
1996 Chinnaiyan AM, Dixit VM. The cell-death machine Current Biology. 6: 555-562. PMID 8805273 DOI: 10.1016/S0960-9822(02)00541-9  0.383
1996 Tewari M, Dixit VM. Recent advances in tumor necrosis factor and CD40 signaling Current Opinion in Genetics and Development. 6: 39-44. PMID 8791485 DOI: 10.1016/S0959-437X(96)90008-8  0.39
1996 Orth K, O'Rourke K, Salvesen GS, Dixit VM. Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases Journal of Biological Chemistry. 271: 20977-20980. PMID 8702858 DOI: 10.1074/Jbc.271.35.20977  0.335
1996 Vincenz C, Dixit VM. 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules Journal of Biological Chemistry. 271: 20029-20034. PMID 8702721 DOI: 10.1074/Jbc.271.33.20029  0.316
1996 Quan LT, Tewari M, O'Rourke K, Dixit V, Snipas SJ, Poirier GG, Ray C, Pickup DJ, Salvesen GS. Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. Proceedings of the National Academy of Sciences of the United States of America. 93: 1972-6. PMID 8700869 DOI: 10.1073/Pnas.93.5.1972  0.396
1996 Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex Cell. 85: 817-827. PMID 8681377 DOI: 10.1016/S0092-8674(00)81266-0  0.395
1996 Orth K, Chinnaiyan AM, Garg M, Froelich CJ, Dixit VM. The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A Journal of Biological Chemistry. 271: 16443-16446. PMID 8663580 DOI: 10.1074/Jbc.271.28.16443  0.395
1996 Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, Dixit VM. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. The Journal of Biological Chemistry. 271: 16720-4. PMID 8663294 DOI: 10.1074/Jbc.271.28.16720  0.312
1996 Pandey A, Liu X, Dixon JE, Di Fiore PP, Dixit VM. Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7. The Journal of Biological Chemistry. 271: 10607-10. PMID 8631863 DOI: 10.1074/Jbc.271.18.10607  0.507
1996 Chinnaiyan AM, Tepper CG, Seldin MF, O'Rourke K, Kischkel FC, Hellbardt S, Krammer PH, Peter ME, Dixit VM. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis Journal of Biological Chemistry. 271: 4961-4965. PMID 8617770 DOI: 10.1074/Jbc.271.9.4961  0.395
1996 Chinnaiyan AM, Orth K, O'Rourke K, Duan H, Poirier GG, Dixit VM. Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases. The Journal of Biological Chemistry. 271: 4573-6. PMID 8617712 DOI: 10.1074/Jbc.271.9.4573  0.371
1996 Duan H, Chinnaiyan AM, Hudson PL, Wing JP, He WW, Dixit VM. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. The Journal of Biological Chemistry. 271: 1621-5. PMID 8576161 DOI: 10.1074/Jbc.271.3.1621  0.351
1995 Pandey A, Lindberg RA, Dixit VM. Cell signalling. Receptor orphans find a family. Current Biology : Cb. 5: 986-9. PMID 8542290 DOI: 10.1016/S0960-9822(95)00195-3  0.463
1995 Shao H, Pandey A, O'Shea KS, Seldin M, Dixit VM. Characterization of B61, the ligand for the Eck receptor protein-tyrosine kinase. The Journal of Biological Chemistry. 270: 5636-41. PMID 7890684 DOI: 10.1074/Jbc.270.10.5636  0.47
1995 Shao H, Lou L, Pandey A, Verderame MF, Siever DA, Dixit VM. cDNA cloning and characterization of a Cek7 receptor protein-tyrosine kinase ligand that is identical to the ligand (ELF-1) for the Mek-4 and Sek receptor protein-tyrosine kinases. The Journal of Biological Chemistry. 270: 3467-70. PMID 7876076 DOI: 10.1074/Jbc.270.8.3467  0.456
1995 Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 81: 801-9. PMID 7774019 DOI: 10.1016/0092-8674(95)90541-3  0.4
1995 Qabar A, Derick L, Lawler J, Dixit V. Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues. The Journal of Biological Chemistry. 270: 12725-9. PMID 7759526 DOI: 10.1074/Jbc.270.21.12725  0.346
1995 Pandey A, Duan H, Di Fiore PP, Dixit VM. The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10. The Journal of Biological Chemistry. 270: 21461-3. PMID 7665556 DOI: 10.1074/Jbc.270.37.21461  0.495
1995 Tewari M, Telford WG, Miller RA, Dixit VM. CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosis Journal of Biological Chemistry. 270: 22705-22708. PMID 7559394 DOI: 10.1074/Jbc.270.39.22705  0.406
1995 Rothe M, Sarma V, Dixit VM, Goeddel DV. TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science (New York, N.Y.). 269: 1424-7. PMID 7544915 DOI: 10.1126/Science.7544915  0.362
1995 Pandey A, Duan H, Dixit VM. Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. The Journal of Biological Chemistry. 270: 19201-4. PMID 7543898 DOI: 10.1074/Jbc.270.33.19201  0.472
1995 Beidler DR, Tewari M, Friesen PD, Poirier G, Dixit VM. The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis. The Journal of Biological Chemistry. 270: 16526-8. PMID 7542648 DOI: 10.1074/Jbc.270.28.16526  0.4
1995 Sarma V, Lin Z, Clark L, Rust BM, Tewari M, Noelle RJ, Dixit VM. Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. The Journal of Biological Chemistry. 270: 12343-6. PMID 7539000 DOI: 10.1074/Jbc.270.21.12343  0.399
1995 Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM. FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis Cell. 81: 505-512. PMID 7538907 DOI: 10.1016/0092-8674(95)90071-3  0.423
1995 Pandey A, Shao H, Marks RM, Polverini PJ, Dixit VM. Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. Science (New York, N.Y.). 268: 567-9. PMID 7536959 DOI: 10.1126/Science.7536959  0.48
1995 Tewari M, Dixit VM. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. The Journal of Biological Chemistry. 270: 3255-60. PMID 7531702 DOI: 10.1074/Jbc.270.7.3255  0.437
1995 Tewari M, Beidler DR, Dixit VM. CrmA-inhibitable cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein during Fas- and tumor necrosis factor-induced apoptosis Journal of Biological Chemistry. 270: 13738-13741. DOI: 10.1074/Jbc.270.32.18738  0.424
1994 Pandey A, Lazar DF, Saltiel AR, Dixit VM. Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. The Journal of Biological Chemistry. 269: 30154-7. PMID 7982920  0.43
1994 Shao H, Lou L, Pandey A, Pasquale EB, Dixit VM. cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. The Journal of Biological Chemistry. 269: 26606-9. PMID 7929389  0.411
1992 Castle VP, Ou X, O'Shea S, Dixit VM. Induction of thrombospondin 1 by retinoic acid is important during differentiation of neuroblastoma cells Journal of Clinical Investigation. 90: 1857-1863. PMID 1430209 DOI: 10.1172/Jci116062  0.322
1992 Stoof TJ, Mitra RS, Sarma V, Dixit VM, Nickoloff BJ. Keratinocyte activation following T-lymphocyte binding. The Journal of Investigative Dermatology. 98: 92-5. PMID 1345824 DOI: 10.1111/1523-1747.Ep12495676  0.356
1991 Barker JNWN, Griffiths CEM, Nickoloff BJ, Mitra RS, Dixit VM. Keratinocytes as initiators of inflammation The Lancet. 337: 211-214. PMID 1670850 DOI: 10.1016/0140-6736(91)92168-2  0.348
1990 O'Shea KS, Liu LH, Kinnunen LH, Dixit VM. Role of the extracellular matrix protein thrombospondin in the early development of the mouse embryo. The Journal of Cell Biology. 111: 2713-23. PMID 2277082 DOI: 10.1083/Jcb.111.6.2713  0.345
1990 Holzman LB, Marks RM, Dixit VM. A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein. Molecular and Cellular Biology. 10: 5830-8. PMID 2233719 DOI: 10.1128/Mcb.10.11.5830  0.357
1990 Schuger L, Dixit VM, Carey TE, Varani J. Modulation of squamous carcinoma cell growth, morphology, adhesiveness and extracellular matrix production by interferon-gamma and tumor necrosis factor-alpha. Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology. 58: 279-86. PMID 2127530 DOI: 10.1159/000163597  0.308
1990 Riser BL, Varani J, Nickoloff BJ, Mitra RS, Dixit VM. Thrombospondin binding by keratinocytes: modulation under conditions which alter thrombospondin biosynthesis. Dermatologica. 180: 60-5. PMID 2107104 DOI: 10.1159/000247991  0.353
1990 Barker JN, Sarma V, Mitra RS, Dixit VM, Nickoloff BJ. Marked synergism between tumor necrosis factor-alpha and interferon-gamma in regulation of keratinocyte-derived adhesion molecules and chemotactic factors. The Journal of Clinical Investigation. 85: 605-8. PMID 2105343 DOI: 10.1172/Jci114481  0.307
1990 Long M, Dixit V. Thrombospondin functions as a cytoadhesion molecule for human hematopoietic progenitor cells Blood. 75: 2311-2318. DOI: 10.1182/Blood.V75.12.2311.Bloodjournal75122311  0.377
1989 Prochownik EV, O'Rourke K, Dixit VM. Expression and analysis of COOH-terminal deletions of the human thrombospondin molecule. The Journal of Cell Biology. 109: 843-52. PMID 2760115 DOI: 10.1083/Jcb.109.2.843  0.365
1989 Varani J, Riser BL, Hughes LA, Carey TE, Fligiel SE, Dixit VM. Characterization of thrombospondin synthesis, secretion and cell surface expression by human tumor cells. Clinical & Experimental Metastasis. 7: 265-76. PMID 2647330 DOI: 10.1007/Bf01753679  0.329
1988 Riser BL, Varani J, O'Rourke K, Dixit VM. Thrombospondin binding by human squamous carcinoma and melanoma cells: relationship to biological activity. Experimental Cell Research. 174: 319-29. PMID 3338492 DOI: 10.1016/0014-4827(88)90303-5  0.316
1987 Frazier WA, Dixit VM, Galvin NJ, Rotwein PR. Structure of human thrombospondin: complete amino acid sequence derived from cDNA. Seminars in Thrombosis and Hemostasis. 13: 255-60. PMID 3686018 DOI: 10.1055/S-2007-1003500  0.541
1987 Galvin NJ, Vance PM, Dixit VM, Fink B, Frazier WA. Interaction of human thrombospondin with types I-V collagen: direct binding and electron microscopy. The Journal of Cell Biology. 104: 1413-22. PMID 3571333 DOI: 10.1083/Jcb.104.5.1413  0.534
1987 Wikner NE, Dixit VM, Frazier WA, Clark RA. Human keratinocytes synthesize and secrete the extracellular matrix protein, thrombospondin. The Journal of Investigative Dermatology. 88: 207-11. PMID 3543145 DOI: 10.1111/1523-1747.Ep12525350  0.532
1986 Dixit VM, Hennessy SW, Grant GA, Rotwein P, Frazier WA. Characterization of a cDNA encoding the heparin and collagen binding domains of human thrombospondin. Proceedings of the National Academy of Sciences of the United States of America. 83: 5449-53. PMID 3461443 DOI: 10.1073/Pnas.83.15.5449  0.538
1986 Dixit VM, Galvin NJ, O'Rourke KM, Frazier WA. Monoclonal antibodies that recognize calcium-dependent structures of human thrombospondin. Characterization and mapping of their epitopes. The Journal of Biological Chemistry. 261: 1962-8. PMID 2418018  0.518
1985 Dixit VM, Haverstick DM, O'Rourke KM, Hennessy SW, Grant GA, Santoro SA, Frazier WA. Effects of anti-thrombospondin monoclonal antibodies on the agglutination of erythrocytes and fixed, activated platelets by purified thrombospondin. Biochemistry. 24: 4270-5. PMID 4052397 DOI: 10.1021/Bi00337A003  0.59
1985 Haverstick DM, Dixit VM, Grant GA, Frazier WA, Santoro SA. Characterization of the platelet agglutinating activity of thrombospondin. Biochemistry. 24: 3128-34. PMID 4027236 DOI: 10.1021/Bi00334A009  0.575
1985 Roberts DD, Haverstick DM, Dixit VM, Frazier WA, Santoro SA, Ginsburg V. The platelet glycoprotein thrombospondin binds specifically to sulfated glycolipids. The Journal of Biological Chemistry. 260: 9405-11. PMID 3926767  0.536
1985 Dixit VM, Haverstick DM, O'Rourke K, Hennessy SW, Broekelmann TJ, McDonald JA, Grant GA, Santoro SA, Frazier WA. Inhibition of platelet aggregation by a monoclonal antibody against human fibronectin. Proceedings of the National Academy of Sciences of the United States of America. 82: 3844-8. PMID 2582428 DOI: 10.1073/Pnas.82.11.3844  0.583
1985 Dixit VM, Haverstick DM, O'Rourke KM, Hennessy SW, Grant GA, Santoro SA, Frazier WA. A monoclonal antibody against human thrombospondin inhibits platelet aggregation. Proceedings of the National Academy of Sciences of the United States of America. 82: 3472-6. PMID 2582413 DOI: 10.1073/Pnas.82.10.3472  0.59
1985 Roberts DD, Sherwood JA, Spitalnik SL, Panton LJ, Howard RJ, Dixit VM, Frazier WA, Miller LH, Ginsburg V. Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence. Nature. 318: 64-6. PMID 2414670 DOI: 10.1038/318064A0  0.549
1985 Galvin NJ, Dixit VM, O'Rourke KM, Santoro SA, Grant GA, Frazier WA. Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing. The Journal of Cell Biology. 101: 1434-41. PMID 2413043 DOI: 10.1083/Jcb.101.4.1434  0.551
1984 Dixit VM, Grant GA, Frazier WA, Santoro SA. Isolation of the fibrinogen-binding region of platelet thrombospondin. Biochemical and Biophysical Research Communications. 119: 1075-81. PMID 6712666 DOI: 10.1016/0006-291X(84)90884-2  0.573
1984 Haverstick DM, Dixit VM, Grant GA, Frazier WA, Santoro SA. Localization of the hemagglutinating activity of platelet thrombospondin to a 140 000-dalton thermolytic fragment. Biochemistry. 23: 5597-603. PMID 6509039 DOI: 10.1021/Bi00318A033  0.572
1984 Dixit VM, Grant GA, Santoro SA, Frazier WA. Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin. The Journal of Biological Chemistry. 259: 10100-5. PMID 6236212  0.542
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