Cameron C. McIntyre, Ph.D. - Publications

Affiliations: 
Case Western Reserve University, Cleveland Heights, OH, United States 
Area:
Deep brain stimulation, Neuromodulation
Website:
http://mcintyrelab.case.edu/

152 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Seas A, Noor MS, Choi KS, Veerakumar A, Obatusin M, Dahill-Fuchel J, Tiruvadi V, Xu E, Riva-Posse P, Rozell CJ, Mayberg HS, McIntyre CC, Waters AC, Howell B. Subcallosal cingulate deep brain stimulation evokes two distinct cortical responses via differential white matter activation. Proceedings of the National Academy of Sciences of the United States of America. 121: e2314918121. PMID 38527192 DOI: 10.1073/pnas.2314918121  0.359
2024 Johnson KA, Dosenbach NUF, Gordon EM, Welle CG, Wilkins KB, Bronte-Stewart HM, Voon V, Morishita T, Sakai Y, Merner AR, Lázaro-Muñoz G, Williamson T, Horn A, Gilron R, O'Keeffe J, ... ... McIntyre CC, et al. Proceedings of the 11th Annual Deep Brain Stimulation Think Tank: pushing the forefront of neuromodulation with functional network mapping, biomarkers for adaptive DBS, bioethical dilemmas, AI-guided neuromodulation, and translational advancements. Frontiers in Human Neuroscience. 18: 1320806. PMID 38450221 DOI: 10.3389/fnhum.2024.1320806  0.668
2024 Bingham CS, McIntyre CC. Coupled Activation of the Hyperdirect and Cerebellothalamic Pathways with Zona Incerta Deep Brain Stimulation. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 38321526 DOI: 10.1002/mds.29717  0.833
2023 Várkuti B, Halász L, Hagh Gooie S, Miklós G, Smits Serena R, van Elswijk G, McIntyre CC, Lempka SF, Lozano AM, Erōss L. Conversion of a medical implant into a versatile computer-brain interface. Brain Stimulation. 17: 39-48. PMID 38145752 DOI: 10.1016/j.brs.2023.12.011  0.677
2023 Noecker AM, Mlakar J, Bijanki KR, Griswold MA, Pouratian N, Sheth SA, McIntyre CC. Stereo-EEG-guided network modulation for psychiatric disorders: Interactive holographic planning. Brain Stimulation. 16: 1799-1805. PMID 38135359 DOI: 10.1016/j.brs.2023.11.003  0.304
2023 Noor MS, Howell B, McIntyre CC. Role of the volume conductor on simulations of local field potential recordings from deep brain stimulation electrodes. Plos One. 18: e0294512. PMID 38011104 DOI: 10.1371/journal.pone.0294512  0.844
2023 Noetscher GM, Tang D, Nummenmaa AR, Bingham CS, McIntyre CC, Makaroff SN. Estimations of Charge Deposition onto Convoluted Axon Surfaces within Extracellular Electric Fields. Ieee Transactions On Bio-Medical Engineering. PMID 37535481 DOI: 10.1109/TBME.2023.3299734  0.781
2023 Bower KL, Noecker AM, Reich MM, McIntyre CC. Quantifying the Variability Associated with Postoperative Localization of Deep Brain Stimulation Electrodes. Stereotactic and Functional Neurosurgery. 1-8. PMID 37379823 DOI: 10.1159/000530462  0.435
2023 Beylergil SB, Noecker AM, Kilbane C, McIntyre CC, Shaikh AG. Does Vestibular Motion Perception Correlate with Axonal Pathways Stimulated by Subthalamic Deep Brain Stimulation in Parkinson's Disease? Cerebellum (London, England). PMID 37308757 DOI: 10.1007/s12311-023-01576-8  0.812
2023 Ng PR, Bush A, Vissani M, McIntyre CC, Richardson RM. Biophysical Principles and Computational Modeling of Deep Brain Stimulation. Neuromodulation : Journal of the International Neuromodulation Society. PMID 37204360 DOI: 10.1016/j.neurom.2023.04.471  0.397
2023 Agharazi H, Hardin EC, Flannery K, Beylergil SB, Noecker A, Kilbane C, Factor SA, McIntyre C, Shaikh AG. Physiological measures and anatomical correlates of subthalamic deep brain stimulation effect on gait in Parkinson's disease. Journal of the Neurological Sciences. 449: 120647. PMID 37100017 DOI: 10.1016/j.jns.2023.120647  0.799
2023 Bower KL, Noecker AM, Frankemolle-Gilbert AM, McIntyre CC. Model-Based Analysis of Pathway Recruitment During Subthalamic Deep Brain Stimulation. Neuromodulation : Journal of the International Neuromodulation Society. PMID 37097269 DOI: 10.1016/j.neurom.2023.02.084  0.481
2023 Bingham CS, Petersen MV, Parent M, McIntyre CC. Evolving characterization of the human hyperdirect pathway. Brain Structure & Function. PMID 36708394 DOI: 10.1007/s00429-023-02610-5  0.807
2022 Tiruvadi V, James S, Howell B, Obatusin M, Crowell A, Riva-Posse P, Gross RE, McIntyre CC, Mayberg HS, Butera R. Mitigating Mismatch Compression in Differential Local Field Potentials. Ieee Transactions On Neural Systems and Rehabilitation Engineering : a Publication of the Ieee Engineering in Medicine and Biology Society. PMID 36288215 DOI: 10.1109/TNSRE.2022.3217469  0.414
2022 Bingham CS, McIntyre CC. Subthalamic deep brain stimulation of an anatomically detailed model of the human hyperdirect pathway. Journal of Neurophysiology. 127: 1209-1220. PMID 35320026 DOI: 10.1152/jn.00004.2022  0.824
2021 Sheth SA, Bijanki KR, Metzger B, Allawala A, Pirtle V, Adkinson JA, Myers J, Mathura RK, Oswalt D, Tsolaki E, Xiao J, Noecker A, Strutt AM, Cohn JF, McIntyre CC, et al. Deep Brain Stimulation for Depression Informed by Intracranial Recordings. Biological Psychiatry. PMID 35063186 DOI: 10.1016/j.biopsych.2021.11.007  0.335
2021 Frankemolle-Gilbert AM, Howell B, Bower KL, Veltink PH, Heida T, McIntyre CC. Comparison of methodologies for modeling directional deep brain stimulation electrodes. Plos One. 16: e0260162. PMID 34910744 DOI: 10.1371/journal.pone.0260162  0.44
2021 Beylergil SB, Murray J, Noecker AM, Gupta P, Kilbane C, McIntyre CC, Ghasia FF, Shaikh AG. Temporal Patterns of Spontaneous Fixational Eye Movements: The Influence of Basal Ganglia. Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society. PMID 34812763 DOI: 10.1097/WNO.0000000000001452  0.749
2021 Widge AS, Zhang F, Gosai A, Papadimitrou G, Wilson-Braun P, Tsintou M, Palanivelu S, Noecker AM, McIntyre CC, O'Donnell L, McLaughlin NCR, Greenberg BD, Makris N, Dougherty DD, Rathi Y. Patient-specific connectomic models correlate with, but do not reliably predict, outcomes in deep brain stimulation for obsessive-compulsive disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 34621015 DOI: 10.1038/s41386-021-01199-9  0.327
2021 Bingham CS, Parent M, McIntyre CC. Histology-driven model of the macaque motor hyperdirect pathway. Brain Structure & Function. PMID 34091730 DOI: 10.1007/s00429-021-02307-7  0.794
2021 Beylergil SB, Noecker AM, Petersen M, Gupta P, Ozinga S, Walker MF, Kilbane C, McIntyre CC, Shaikh AG. Subthalamic deep brain stimulation affects heading perception in Parkinson's disease. Journal of Neurology. PMID 34003373 DOI: 10.1007/s00415-021-10616-4  0.8
2021 Noor MS, McIntyre CC. Biophysical characterization of local field potential recordings from directional deep brain stimulation electrodes. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. PMID 33867263 DOI: 10.1016/j.clinph.2021.01.027  0.842
2021 Howell B, Isbaine F, Willie JT, Opri E, Gross RE, De Hemptinne C, Starr PA, McIntyre CC, Miocinovic S. Image-Based Biophysical Modeling Predicts Cortical Potentials Evoked with Subthalamic Deep Brain Stimulation. Brain Stimulation. PMID 33757931 DOI: 10.1016/j.brs.2021.03.009  0.738
2021 Yalaz M, Noor S, McIntyre C, Butz M, Schnitzler A, Deuschl G, Höft M. DBS electrode localization and rotational orientation detection using SQUID-based magnetoencephalography. Journal of Neural Engineering. PMID 33503598 DOI: 10.1088/1741-2552/abe099  0.322
2021 Beylergil SB, Murray J, Noecker AM, Gupta P, Kilbane C, McIntyre CC, Shaikh AG, Ghasia FF. Effects of subthalamic deep brain stimulation on fixational eye movements in Parkinson's disease. Journal of Computational Neuroscience. PMID 33464428 DOI: 10.1007/s10827-020-00773-2  0.794
2021 Noecker AM, Frankemolle-Gilbert AM, Howell B, Petersen MV, Beylergil SB, Shaikh AG, McIntyre CC. StimVision v2: Examples and Applications in Subthalamic Deep Brain Stimulation for Parkinson's Disease. Neuromodulation : Journal of the International Neuromodulation Society. PMID 33389779 DOI: 10.1111/ner.13350  0.839
2020 Picillo M, Phokaewvarangkul O, Poon YY, McIntyre CC, Beylergil SB, Munhoz RP, Kalia SK, Hodaie M, Lozano AM, Fasano A. Levodopa Versus Dopamine Agonist After Subthalamic Stimulation in Parkinson's Disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33165964 DOI: 10.1002/mds.28382  0.729
2020 Bower KL, McIntyre CC. Deep brain stimulation of terminating axons. Brain Stimulation. PMID 32919091 DOI: 10.1016/j.brs.2020.09.001  0.52
2020 Ramirez-Zamora A, Giordano J, Gunduz A, Alcantara J, Cagle JN, Cernera S, Difuntorum P, Eisinger RS, Gomez J, Long S, Parks B, Wong JK, Chiu S, Patel B, Grill WM, ... ... McIntyre C, et al. Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology. Frontiers in Human Neuroscience. 14: 54. PMID 32292333 DOI: 10.3389/Fnhum.2020.00054  0.601
2020 Sweet JA, Thyagaraj S, Chen Z, Tatsuoka C, Staudt MD, Calabrese JR, Miller JP, Gao K, McIntyre CC. Connectivity-based identification of a potential neurosurgical target for mood disorders. Journal of Psychiatric Research. 125: 113-120. PMID 32272241 DOI: 10.1016/j.jpsychires.2020.03.011  0.337
2020 Howell B, McIntyre CC. Feasibility of Interferential and Pulsed Transcranial Electrical Stimulation for Neuromodulation at the Human Scale. Neuromodulation : Journal of the International Neuromodulation Society. PMID 32147953 DOI: 10.1111/ner.13137  0.489
2019 Gunalan K, McIntyre CC. Biophysical reconstruction of the signal conduction underlying short-latency cortical evoked potentials generated by subthalamic deep brain stimulation. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. PMID 31757636 DOI: 10.1016/J.Clinph.2019.09.020  0.822
2019 Petersen MV, Mlakar J, Haber SN, Parent M, Smith Y, Strick PL, Griswold MA, McIntyre CC. Holographic Reconstruction of Axonal Pathways in the Human Brain. Neuron. PMID 31708306 DOI: 10.1016/J.Neuron.2019.09.030  0.351
2019 Ramirez-Zamora A, Giordano J, Boyden ES, Gradinaru V, Gunduz A, Starr PA, Sheth SA, McIntyre CC, Fox MD, Vitek J, Vedam-Mai V, Akbar U, Almeida L, Bronte-Stewart HM, Mayberg HS, et al. Proceedings of the Sixth Deep Brain Stimulation Think Tank Modulation of Brain Networks and Application of Advanced Neuroimaging, Neurophysiology, and Optogenetics. Frontiers in Neuroscience. 13: 936. PMID 31572109 DOI: 10.3389/Fnins.2019.00936  0.706
2019 Cagnan H, Denison T, McIntyre C, Brown P. Publisher Correction: Emerging technologies for improved deep brain stimulation. Nature Biotechnology. PMID 31501564 DOI: 10.1038/S41587-019-0274-0  0.405
2019 Cagnan H, Denison T, McIntyre C, Brown P. Emerging technologies for improved deep brain stimulation. Nature Biotechnology. PMID 31477926 DOI: 10.1038/S41587-019-0244-6  0.547
2019 Farokhniaee A, McIntyre CC. Theoretical principles of deep brain stimulation induced synaptic suppression. Brain Stimulation. PMID 31351911 DOI: 10.1016/J.Brs.2019.07.005  0.845
2019 Beylergil SB, Ozinga S, Walker MF, McIntyre CC, Shaikh AG. Vestibular heading perception in Parkinson's disease. Progress in Brain Research. 249: 307-319. PMID 31325990 DOI: 10.1016/Bs.Pbr.2019.03.034  0.777
2019 Sweet JA, Beylergil SB, Thyagaraj S, Herring EZ, Drapekin JE, Gao K, Calabrese JR, Miller JP, McIntyre CC. Clinical Evaluation of Cingulum Bundle Connectivity for Neurosurgical Hypothesis Development. Neurosurgery. PMID 31264700 DOI: 10.1093/neuros/nyz225  0.744
2019 Howell B, Gunalan K, McIntyre CC. A Driving-Force Predictor for Estimating Pathway Activation in Patient-Specific Models of Deep Brain Stimulation. Neuromodulation : Journal of the International Neuromodulation Society. PMID 30775834 DOI: 10.1111/Ner.12929  0.805
2019 Lozano AM, Lipsman N, Bergman H, Brown P, Chabardes S, Chang JW, Matthews K, McIntyre CC, Schlaepfer TE, Schulder M, Temel Y, Volkmann J, Krauss JK. Deep brain stimulation: current challenges and future directions. Nature Reviews. Neurology. PMID 30683913 DOI: 10.1038/S41582-018-0128-2  0.507
2018 Howell B, Choi KS, Gunalan K, Rajendra J, Mayberg HS, McIntyre CC. Quantifying the axonal pathways directly stimulated in therapeutic subcallosal cingulate deep brain stimulation. Human Brain Mapping. PMID 30311317 DOI: 10.1002/Hbm.24419  0.815
2018 Maling N, Lempka SF, Blumenfeld Z, Bronte-Stewart HM, McIntyre CC. Biophysical Basis of Subthalamic Local Field Potentials Recorded from Deep Brain Stimulation Electrodes. Journal of Neurophysiology. PMID 30020838 DOI: 10.1152/Jn.00067.2018  0.844
2018 Anderson RW, Farokhniaee A, Gunalan K, Howell B, McIntyre CC. Action potential initiation, propagation, and cortical invasion in the hyperdirect pathway during subthalamic deep brain stimulation. Brain Stimulation. PMID 29779963 DOI: 10.1016/J.Brs.2018.05.008  0.839
2018 Lempka SF, Howell B, Gunalan K, Machado AG, McIntyre CC. Characterization of the stimulus waveforms generated by implantable pulse generators for deep brain stimulation. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 129: 731-742. PMID 29448149 DOI: 10.1016/J.Clinph.2018.01.015  0.821
2018 Gunalan K, Howell B, McIntyre CC. Quantifying axonal responses in patient-specific models of subthalamic deep brain stimulation. Neuroimage. PMID 29331449 DOI: 10.1016/J.Neuroimage.2018.01.015  0.819
2017 Ramirez-Zamora A, Giordano JJ, Gunduz A, Brown P, Sanchez JC, Foote KD, Almeida L, Starr PA, Bronte-Stewart HM, Hu W, McIntyre C, Goodman W, Kumsa D, Grill WM, Walker HC, et al. Evolving Applications, Technological Challenges and Future Opportunities in Neuromodulation: Proceedings of the Fifth Annual Deep Brain Stimulation Think Tank. Frontiers in Neuroscience. 11: 734. PMID 29416498 DOI: 10.3389/Fnins.2017.00734  0.831
2017 Choi KS, Noecker AM, Riva-Posse P, Rajendra JK, Gross RE, Mayberg HS, McIntyre CC. Impact of brain shift on subcallosal cingulate deep brain stimulation. Brain Stimulation. PMID 29246748 DOI: 10.1016/J.Brs.2017.12.001  0.493
2017 Noecker AM, Choi KS, Riva-Posse P, Gross RE, Mayberg HS, McIntyre CC. StimVision Software: Examples and Applications in Subcallosal Cingulate Deep Brain Stimulation for Depression. Neuromodulation : Journal of the International Neuromodulation Society. PMID 28653482 DOI: 10.1111/ner.12625  0.482
2017 Gunalan K, Chaturvedi A, Howell B, Duchin Y, Lempka SF, Patriat R, Sapiro G, Harel N, McIntyre CC. Creating and parameterizing patient-specific deep brain stimulation pathway-activation models using the hyperdirect pathway as an example. Plos One. 12: e0176132. PMID 28441410 DOI: 10.1371/Journal.Pone.0176132  0.832
2017 Riva-Posse P, Choi KS, Holtzheimer PE, Crowell AL, Garlow SJ, Rajendra JK, McIntyre CC, Gross RE, Mayberg HS. A connectomic approach for subcallosal cingulate deep brain stimulation surgery: prospective targeting in treatment-resistant depression. Molecular Psychiatry. PMID 28397839 DOI: 10.1038/Mp.2017.59  0.435
2017 Choi KS, Noecker A, Posse PR, Rajendra J, Gross R, Mayberg H, McIntyre C. 945. The Effect of Brain Shift in Connectomic Targeting for Subcallosal Cingulate Deep Brain Stimulation Biological Psychiatry. 81. DOI: 10.1016/J.Biopsych.2017.02.671  0.456
2016 Hamel W, Köppen JA, Alesch F, Antonini A, Barcia JA, Bergman H, Chabardes S, Contarino MF, Cornu P, Demmel W, Deuschl G, Fasano A, Kühn AA, Limousin P, McIntyre CC, et al. Targeting of the subthalamic nucleus for deep brain stimulation: a survey among Parkinson's disease specialists. World Neurosurgery. PMID 27838430 DOI: 10.1016/J.Wneu.2016.11.012  0.476
2016 Howell B, McIntyre CC. Role of Soft-Tissue Heterogeneity in Computational Models of Deep Brain Stimulation. Brain Stimulation. PMID 27720186 DOI: 10.1016/j.brs.2016.09.001  0.513
2016 McIntyre CC, Anderson RW. Deep brain stimulation mechanisms: the control of network activity via neurochemistry modulation. Journal of Neurochemistry. PMID 27273305 DOI: 10.1111/jnc.13649  0.546
2016 Howell B, McIntyre CC. Analyzing the tradeoff between electrical complexity and accuracy in patient-specific computational models of deep brain stimulation. Journal of Neural Engineering. 13: 036023. PMID 27172137 DOI: 10.1088/1741-2560/13/3/036023  0.51
2016 Rossi PJ, Gunduz A, Judy J, Wilson L, Machado A, Giordano JJ, Elias WJ, Rossi MA, Butson CL, Fox MD, McIntyre CC, Pouratian N, Swann NC, de Hemptinne C, Gross RE, et al. Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies. Frontiers in Neuroscience. 10: 119. PMID 27092042 DOI: 10.3389/Fnins.2016.00119  0.752
2015 Hartmann CJ, Lujan JL, Chaturvedi A, Goodman WK, Okun MS, McIntyre CC, Haq IU. Tractography Activation Patterns in Dorsolateral Prefrontal Cortex Suggest Better Clinical Responses in OCD DBS. Frontiers in Neuroscience. 9: 519. PMID 26834544 DOI: 10.3389/Fnins.2015.00519  0.784
2015 Butson CR, McIntyre CC. The Use of Stimulation Field Models for Deep Brain Stimulation Programming. Brain Stimulation. 8: 976-8. PMID 26358487 DOI: 10.1016/J.Brs.2015.06.005  0.71
2015 Shamir RR, Dolber T, Noecker AM, Walter BL, McIntyre CC. Machine Learning Approach to Optimizing Combined Stimulation and Medication Therapies for Parkinson's Disease. Brain Stimulation. PMID 26140956 DOI: 10.1016/J.Brs.2015.06.003  0.742
2015 van Dijk KJ, Verhagen R, Chaturvedi A, McIntyre CC, Bour LJ, Heida C, Veltink PH. A novel lead design enables selective deep brain stimulation of neural populations in the subthalamic region. Journal of Neural Engineering. 12: 046003. PMID 26020096 DOI: 10.1088/1741-2560/12/4/046003  0.688
2015 Reich MM, Steigerwald F, Sawalhe AD, Reese R, Gunalan K, Johannes S, Nickl R, Matthies C, McIntyre CC, Volkmann J. Short pulse width widens the therapeutic window of subthalamic neurostimulation. Annals of Clinical and Translational Neurology. 2: 427-32. PMID 25909087 DOI: 10.1002/Acn3.168  0.743
2015 Lempka SF, McIntyre CC, Kilgore KL, Machado AG. Computational analysis of kilohertz frequency spinal cord stimulation for chronic pain management. Anesthesiology. 122: 1362-76. PMID 25822589 DOI: 10.1097/Aln.0000000000000649  0.634
2015 Gunduz A, Morita H, Rossi PJ, Allen WL, Alterman RL, Bronte-Stewart H, Butson CR, Charles D, Deckers S, de Hemptinne C, DeLong M, Dougherty D, Ellrich J, Foote KD, Giordano J, ... ... McIntyre C, et al. Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What's in the Pipeline. The International Journal of Neuroscience. 1-11. PMID 25526555 DOI: 10.3109/00207454.2014.999268  0.826
2015 Bronstein JM, Tagliati M, McIntyre C, Chen R, Cheung T, Hargreaves EL, Israel Z, Moffitt M, Montgomery EB, Stypulkowski P, Shils J, Denison T, Vitek J, Volkman J, Wertheimer J, et al. The rationale driving the evolution of deep brain stimulation to constant-current devices. Neuromodulation : Journal of the International Neuromodulation Society. 18: 85-8; discussion 88-. PMID 25171762 DOI: 10.1111/Ner.12227  0.836
2015 McIntyre CC, Chaturvedi A, Shamir RR, Lempka SF. Engineering the next generation of clinical deep brain stimulation technology. Brain Stimulation. 8: 21-6. PMID 25161150 DOI: 10.1016/J.Brs.2014.07.039  0.824
2014 Shamir RR, Dolbert T, Noecker AM, Frankemolle AM, Walter BL, McIntyre CC. A method for predicting the outcomes of combined pharmacologic and deep brain stimulation therapy for Parkinson's disease. Medical Image Computing and Computer-Assisted Intervention : Miccai ... International Conference On Medical Image Computing and Computer-Assisted Intervention. 17: 188-95. PMID 25485378 DOI: 10.1007/978-3-319-10470-6_24  0.82
2014 Sweet JA, Walter BL, Miller JP, McIntyre CC. Response. Journal of Neurosurgery. 121: 495. PMID 25221808 DOI: 10.3171/2014.3.JNS14544  0.477
2014 Cooper SE, Driesslein KG, Noecker AM, McIntyre CC, Machado AM, Butson CR. Anatomical targets associated with abrupt versus gradual washout of subthalamic deep brain stimulation effects on bradykinesia. Plos One. 9: e99663. PMID 25098453 DOI: 10.1371/Journal.Pone.0099663  0.755
2014 Cheung T, Noecker AM, Alterman RL, McIntyre CC, Tagliati M. Defining a therapeutic target for pallidal deep brain stimulation for dystonia. Annals of Neurology. 76: 22-30. PMID 24852850 DOI: 10.1002/ana.24187  0.561
2014 Riva-Posse P, Choi KS, Holtzheimer PE, McIntyre CC, Gross RE, Chaturvedi A, Crowell AL, Garlow SJ, Rajendra JK, Mayberg HS. Defining critical white matter pathways mediating successful subcallosal cingulate deep brain stimulation for treatment-resistant depression. Biological Psychiatry. 76: 963-9. PMID 24832866 DOI: 10.1016/J.Biopsych.2014.03.029  0.608
2014 Sweet JA, Walter BL, Gunalan K, Chaturvedi A, McIntyre CC, Miller JP. Fiber tractography of the axonal pathways linking the basal ganglia and cerebellum in Parkinson disease: implications for targeting in deep brain stimulation. Journal of Neurosurgery. 120: 988-96. PMID 24484226 DOI: 10.3171/2013.12.Jns131537  0.831
2014 Shamir RR, Noecker A, McIntyre CC. Deep Brain Stimulation Frontiers For Young Minds. 2. DOI: 10.3389/Frym.2014.00012  0.683
2013 Gorniak SL, McIntyre CC, Alberts JL. Bimanual force coordination in Parkinson's disease patients with bilateral subthalamic deep brain stimulation. Plos One. 8: e78934. PMID 24244388 DOI: 10.1371/Journal.Pone.0078934  0.508
2013 McIntyre CC, Foutz TJ. Computational modeling of deep brain stimulation. Handbook of Clinical Neurology. 116: 55-61. PMID 24112884 DOI: 10.1016/B978-0-444-53497-2.00005-X  0.84
2013 Chaturvedi A, Luján JL, McIntyre CC. Artificial neural network based characterization of the volume of tissue activated during deep brain stimulation. Journal of Neural Engineering. 10: 056023. PMID 24060691 DOI: 10.1088/1741-2560/10/5/056023  0.795
2013 Arlow RL, Foutz TJ, McIntyre CC. Theoretical principles underlying optical stimulation of myelinated axons expressing channelrhodopsin-2. Neuroscience. 248: 541-51. PMID 23811392 DOI: 10.1016/J.Neuroscience.2013.06.031  0.752
2013 Lujan JL, Chaturvedi A, Choi KS, Holtzheimer PE, Gross RE, Mayberg HS, McIntyre CC. Tractography-activation models applied to subcallosal cingulate deep brain stimulation. Brain Stimulation. 6: 737-9. PMID 23602025 DOI: 10.1016/J.Brs.2013.03.008  0.81
2013 Lempka SF, McIntyre CC. Theoretical analysis of the local field potential in deep brain stimulation applications. Plos One. 8: e59839. PMID 23555799 DOI: 10.1371/Journal.Pone.0059839  0.775
2013 Cooper SE, McIntyre CC, Fernandez HH, Vitek JL. Association of deep brain stimulation washout effects with Parkinson disease duration. Jama Neurology. 70: 95-9. PMID 23070397 DOI: 10.1001/Jamaneurol.2013.581  0.682
2013 Dietz J, Noecker AM, McIntyre CC, Mikos A, Bowers D, Foote KD, Okun MS. Stimulation region within the globus pallidus does not affect verbal fluency performance. Brain Stimulation. 6: 248-53. PMID 22766102 DOI: 10.1016/J.Brs.2012.05.011  0.478
2012 Foutz TJ, Ackermann DM, Kilgore KL, McIntyre CC. Energy efficient neural stimulation: coupling circuit design and membrane biophysics. Plos One. 7: e51901. PMID 23272188 DOI: 10.1371/Journal.Pone.0051901  0.784
2012 Rubin JE, McIntyre CC, Turner RS, Wichmann T. Basal ganglia activity patterns in parkinsonism and computational modeling of their downstream effects. The European Journal of Neuroscience. 36: 2213-28. PMID 22805066 DOI: 10.1111/J.1460-9568.2012.08108.X  0.434
2012 Johnson MD, Zhang J, Ghosh D, McIntyre CC, Vitek JL. Neural targets for relieving parkinsonian rigidity and bradykinesia with pallidal deep brain stimulation. Journal of Neurophysiology. 108: 567-77. PMID 22514292 DOI: 10.1152/jn.00039.2012  0.788
2012 Foutz TJ, Arlow RL, McIntyre CC. Theoretical principles underlying optical stimulation of a channelrhodopsin-2 positive pyramidal neuron. Journal of Neurophysiology. 107: 3235-45. PMID 22442566 DOI: 10.1152/Jn.00501.2011  0.775
2012 Chaturvedi A, Foutz TJ, McIntyre CC. Current steering to activate targeted neural pathways during deep brain stimulation of the subthalamic region. Brain Stimulation. 5: 369-77. PMID 22277548 DOI: 10.1016/J.Brs.2011.05.002  0.853
2012 Lujan JL, Chaturvedi A, Malone DA, Rezai AR, Machado AG, McIntyre CC. Axonal pathways linked to therapeutic and nontherapeutic outcomes during psychiatric deep brain stimulation. Human Brain Mapping. 33: 958-68. PMID 21520343 DOI: 10.1002/Hbm.21262  0.777
2012 Lujan JL, McIntyre CC. Mechanisms of action of deep brain stimulation for the treatment of psychiatric disorders Deep Brain Stimulation: a New Frontier in Psychiatry. 21-33. DOI: 10.1007/978-3-642-30991-5_3  0.683
2011 Taljan K, McIntyre C, Sakaie K. Anatomical connectivity between subcortical structures. Brain Connectivity. 1: 111-8. PMID 22433007 DOI: 10.1089/Brain.2011.0011  0.775
2011 McIntyre CC, Richardson SJ, Frankemolle AM, Varga G, Noecker AM, Alberts JL. Improving postural stability via computational modeling approach to deep brain stimulation programming. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2011: 675-6. PMID 22254399 DOI: 10.1109/IEMBS.2011.6090151  0.845
2011 Lempka SF, Johnson MD, Moffitt MA, Otto KJ, Kipke DR, McIntyre CC. Theoretical analysis of intracortical microelectrode recordings. Journal of Neural Engineering. 8: 045006. PMID 21775783 DOI: 10.1088/1741-2560/8/4/045006  0.81
2011 Lehman JF, Greenberg BD, McIntyre CC, Rasmussen SA, Haber SN. Rules ventral prefrontal cortical axons use to reach their targets: implications for diffusion tensor imaging tractography and deep brain stimulation for psychiatric illness. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10392-402. PMID 21753016 DOI: 10.1523/Jneurosci.0595-11.2011  0.356
2011 Cooper SE, Noecker AM, Abboud H, Vitek JL, McIntyre CC. Return of bradykinesia after subthalamic stimulation ceases: relationship to electrode location. Experimental Neurology. 231: 207-13. PMID 21736878 DOI: 10.1016/j.expneurol.2011.06.010  0.725
2011 Lee KH, Hitti FL, Chang SY, Lee DC, Roberts DW, McIntyre CC, Leiter JC. High frequency stimulation abolishes thalamic network oscillations: an electrophysiological and computational analysis. Journal of Neural Engineering. 8: 046001. PMID 21623007 DOI: 10.1088/1741-2560/8/4/046001  0.617
2011 Butson CR, Cooper SE, Henderson JM, Wolgamuth B, McIntyre CC. Probabilistic analysis of activation volumes generated during deep brain stimulation. Neuroimage. 54: 2096-104. PMID 20974269 DOI: 10.1016/J.Neuroimage.2010.10.059  0.767
2011 Xu W, Miocinovic S, Zhang J, Baker KB, McIntyre CC, Vitek JL. Dissociation of motor symptoms during deep brain stimulation of the subthalamic nucleus in the region of the internal capsule. Experimental Neurology. 228: 294-7. PMID 20713049 DOI: 10.1016/J.Expneurol.2010.08.007  0.8
2011 Mikos A, Bowers D, Noecker AM, McIntyre CC, Won M, Chaturvedi A, Foote KD, Okun MS. Patient-specific analysis of the relationship between the volume of tissue activated during DBS and verbal fluency. Neuroimage. 54: S238-46. PMID 20362061 DOI: 10.1016/J.Neuroimage.2010.03.068  0.652
2010 Foutz TJ, McIntyre CC. Evaluation of novel stimulus waveforms for deep brain stimulation. Journal of Neural Engineering. 7: 066008. PMID 21084732 DOI: 10.1088/1741-2560/7/6/066008  0.81
2010 Alberts JL, Hallahan K, Thota A, Noecker AM, Vitek JL, McIntyre CC. Reducing cognitive-motor declines associated with bilateral subthalamic deep brain stimulation through computational modelling in a Parkinson's disease patient. Journal of Neurology, Neurosurgery, and Psychiatry. 81: 1170-2. PMID 20802213 DOI: 10.1136/jnnp.2008.160093  0.708
2010 Chaturvedi A, Butson CR, Lempka SF, Cooper SE, McIntyre CC. Patient-specific models of deep brain stimulation: influence of field model complexity on neural activation predictions. Brain Stimulation. 3: 65-7. PMID 20607090 DOI: 10.1016/J.Brs.2010.01.003  0.845
2010 Lempka SF, Johnson MD, Miocinovic S, Vitek JL, McIntyre CC. Current-controlled deep brain stimulation reduces in vivo voltage fluctuations observed during voltage-controlled stimulation. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 121: 2128-33. PMID 20493764 DOI: 10.1016/J.Clinph.2010.04.026  0.828
2010 Hahn PJ, McIntyre CC. Modeling shifts in the rate and pattern of subthalamopallidal network activity during deep brain stimulation. Journal of Computational Neuroscience. 28: 425-41. PMID 20309620 DOI: 10.1007/S10827-010-0225-8  0.75
2010 Frankemolle AM, Wu J, Noecker AM, Voelcker-Rehage C, Ho JC, Vitek JL, McIntyre CC, Alberts JL. Reversing cognitive-motor impairments in Parkinson's disease patients using a computational modelling approach to deep brain stimulation programming. Brain : a Journal of Neurology. 133: 746-61. PMID 20061324 DOI: 10.1093/brain/awp315  0.83
2010 McIntyre CC, Hahn PJ. Network perspectives on the mechanisms of deep brain stimulation. Neurobiology of Disease. 38: 329-37. PMID 19804831 DOI: 10.1016/J.Nbd.2009.09.022  0.76
2009 McIntyre CC, Frankenmolle AM, Wu J, Noecker AM, Alberts JL. Customizing deep brain stimulation to the patient using computational models. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 4228-9. PMID 19965023 DOI: 10.1109/IEMBS.2009.5334592  0.33
2009 Luján JL, Noecker AM, Butson CR, Cooper SE, Walter BL, Vitek JL, McIntyre CC. Automated 3-dimensional brain atlas fitting to microelectrode recordings from deep brain stimulation surgeries. Stereotactic and Functional Neurosurgery. 87: 229-40. PMID 19556832 DOI: 10.1159/000225976  0.834
2009 Lempka SF, Miocinovic S, Johnson MD, Vitek JL, McIntyre CC. In vivo impedance spectroscopy of deep brain stimulation electrodes. Journal of Neural Engineering. 6: 046001. PMID 19494421 DOI: 10.1088/1741-2560/6/4/046001  0.835
2009 Johnson MD, Vitek JL, McIntyre CC. Pallidal stimulation that improves parkinsonian motor symptoms also modulates neuronal firing patterns in primary motor cortex in the MPTP-treated monkey. Experimental Neurology. 219: 359-62. PMID 19409895 DOI: 10.1016/j.expneurol.2009.04.022  0.751
2009 Miocinovic S, Lempka SF, Russo GS, Maks CB, Butson CR, Sakaie KE, Vitek JL, McIntyre CC. Experimental and theoretical characterization of the voltage distribution generated by deep brain stimulation. Experimental Neurology. 216: 166-76. PMID 19118551 DOI: 10.1016/J.Expneurol.2008.11.024  0.843
2009 Maks CB, Butson CR, Walter BL, Vitek JL, McIntyre CC. Deep brain stimulation activation volumes and their association with neurophysiological mapping and therapeutic outcomes. Journal of Neurology, Neurosurgery, and Psychiatry. 80: 659-66. PMID 18403440 DOI: 10.1136/Jnnp.2007.126219  0.861
2009 McIntyre CC. Chapter 16 – Computational Modeling of Deep Brain Stimulation Neuromodulation. 171-178. DOI: 10.1016/B978-0-12-374248-3.00017-3  0.544
2008 Butson CR, McIntyre CC. Current steering to control the volume of tissue activated during deep brain stimulation. Brain Stimulation. 1: 7-15. PMID 19142235 DOI: 10.1016/J.Brs.2007.08.004  0.753
2008 Johnson MD, McIntyre CC. Quantifying the neural elements activated and inhibited by globus pallidus deep brain stimulation. Journal of Neurophysiology. 100: 2549-63. PMID 18768645 DOI: 10.1152/jn.90372.2008  0.719
2008 Lujan JL, Chaturvedi A, McIntyre CC. Tracking the mechanisms of deep brain stimulation for neuropsychiatric disorders. Frontiers in Bioscience : a Journal and Virtual Library. 13: 5892-904. PMID 18508630 DOI: 10.2741/3124  0.794
2008 Johnson MD, Miocinovic S, McIntyre CC, Vitek JL. Mechanisms and targets of deep brain stimulation in movement disorders. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 5: 294-308. PMID 18394571 DOI: 10.1016/J.Nurt.2008.01.010  0.859
2008 Hahn PJ, Russo GS, Hashimoto T, Miocinovic S, Xu W, McIntyre CC, Vitek JL. Pallidal burst activity during therapeutic deep brain stimulation. Experimental Neurology. 211: 243-51. PMID 18355810 DOI: 10.1016/J.Expneurol.2008.01.032  0.837
2008 Guo Y, Rubin JE, McIntyre CC, Vitek JL, Terman D. Thalamocortical relay fidelity varies across subthalamic nucleus deep brain stimulation protocols in a data-driven computational model. Journal of Neurophysiology. 99: 1477-92. PMID 18171706 DOI: 10.1152/Jn.01080.2007  0.707
2008 Nair DR, Burgess R, McIntyre CC, Lüders H. Chronic subdural electrodes in the management of epilepsy. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 119: 11-28. PMID 18035590 DOI: 10.1016/J.Clinph.2007.09.117  0.387
2007 McIntyre CC, Miocinovic S, Butson CR. Computational analysis of deep brain stimulation. Expert Review of Medical Devices. 4: 615-22. PMID 17850196 DOI: 10.1586/17434440.4.5.615  0.833
2007 Butson CR, Noecker AM, Maks CB, McIntyre CC. StimExplorer: deep brain stimulation parameter selection software system. Acta Neurochirurgica. Supplement. 97: 569-74. PMID 17691349 DOI: 10.1007/978-3-211-33081-4_66  0.741
2007 Miocinovic S, Noecker AM, Maks CB, Butson CR, McIntyre CC. Cicerone: stereotactic neurophysiological recording and deep brain stimulation electrode placement software system. Acta Neurochirurgica. Supplement. 97: 561-7. PMID 17691348 DOI: 10.1007/978-3-211-33081-4_65  0.811
2007 Butson CR, McIntyre CC. Differences among implanted pulse generator waveforms cause variations in the neural response to deep brain stimulation. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 118: 1889-94. PMID 17581776 DOI: 10.1016/J.Clinph.2007.05.061  0.747
2007 Miocinovic S, Zhang J, Xu W, Russo GS, Vitek JL, McIntyre CC. Stereotactic neurosurgical planning, recording, and visualization for deep brain stimulation in non-human primates. Journal of Neuroscience Methods. 162: 32-41. PMID 17275094 DOI: 10.1016/J.Jneumeth.2006.12.007  0.809
2007 Butson CR, Cooper SE, Henderson JM, McIntyre CC. Patient-specific analysis of the volume of tissue activated during deep brain stimulation. Neuroimage. 34: 661-70. PMID 17113789 DOI: 10.1016/J.Neuroimage.2006.09.034  0.779
2006 Lempka SF, Johnson MD, Barnett DW, Moffitt MA, Otto KJ, Kipke DR, McIntyre CC. Optimization of microelectrode design for cortical recording based on thermal noise considerations. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 1: 3361-4. PMID 17947023 DOI: 10.1109/IEMBS.2006.259432  0.804
2006 McIntyre CC, Butson CR, Maks CB, Noecker AM. Optimizing deep brain stimulation parameter selection with detailed models of the electrode-tissue interface. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 1: 893-5. PMID 17946871 DOI: 10.1109/IEMBS.2006.260844  0.724
2006 Chaturvedi A, Butson CR, Cooper SE, McIntyre CC. Subthalamic nucleus deep brain stimulation: accurate axonal threshold prediction with diffusion tensor based electric field models. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 1: 1240-3. PMID 17946452 DOI: 10.1109/IEMBS.2006.260502  0.782
2006 Butson CR, Cooper SE, Henderson JM, McIntyre CC. Predicting the effects of deep brain stimulation with diffusion tensor based electric field models. Medical Image Computing and Computer-Assisted Intervention : Miccai ... International Conference On Medical Image Computing and Computer-Assisted Intervention. 9: 429-37. PMID 17354801  0.738
2006 Miocinovic S, Parent M, Butson CR, Hahn PJ, Russo GS, Vitek JL, McIntyre CC. Computational analysis of subthalamic nucleus and lenticular fasciculus activation during therapeutic deep brain stimulation. Journal of Neurophysiology. 96: 1569-80. PMID 16738214 DOI: 10.1152/Jn.00305.2006  0.842
2006 Butson CR, McIntyre CC. Role of electrode design on the volume of tissue activated during deep brain stimulation. Journal of Neural Engineering. 3: 1-8. PMID 16510937 DOI: 10.1088/1741-2560/3/1/001  0.739
2006 Butson CR, Maks CB, McIntyre CC. Sources and effects of electrode impedance during deep brain stimulation. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 117: 447-54. PMID 16376143 DOI: 10.1016/J.Clinph.2005.10.007  0.719
2005 Butson CR, McIntyre CC. Tissue and electrode capacitance reduce neural activation volumes during deep brain stimulation. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 116: 2490-500. PMID 16125463 DOI: 10.1016/J.Clinph.2005.06.023  0.739
2005 Moffitt MA, McIntyre CC. Model-based analysis of cortical recording with silicon microelectrodes. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 116: 2240-50. PMID 16055377 DOI: 10.1016/J.Clinph.2005.05.018  0.775
2005 Butson CR, McIntyre CC. DEEP brain stimulation of the subthalamic nucleus: Model-based analysis of the effects of electrode capacitance on the volume of activation 2nd International Ieee Embs Conference On Neural Engineering. 2005: 196-197. DOI: 10.1109/CNE.2005.1419589  0.715
2005 Moffitt MA, McIntyre CC. Cortical recording with silicon microelectrodes: Model-based analysis of contact dimension and encapsulation changes on recorded waveforms 2nd International Ieee Embs Conference On Neural Engineering. 2005: 149-150. DOI: 10.1109/CNE.2005.1419575  0.702
2004 McIntyre CC, Savasta M, Kerkerian-Le Goff L, Vitek JL. Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 115: 1239-48. PMID 15134690 DOI: 10.1016/j.clinph.2003.12.024  0.726
2004 McIntyre CC, Savasta M, Walter BL, Vitek JL. How does deep brain stimulation work? Present understanding and future questions. Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society. 21: 40-50. PMID 15097293 DOI: 10.2217/EBO.13.564  0.788
2004 McIntyre CC, Mori S, Sherman DL, Thakor NV, Vitek JL. Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 115: 589-95. PMID 15036055 DOI: 10.1016/J.Clinph.2003.10.033  0.743
2004 Moffitt MA, McIntyre CC, Grill WM. Prediction of myelinated nerve fiber stimulation thresholds: limitations of linear models. Ieee Transactions On Bio-Medical Engineering. 51: 229-36. PMID 14765695 DOI: 10.1109/Tbme.2003.820382  0.754
2004 McIntyre CC, Grill WM, Sherman DL, Thakor NV. Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition. Journal of Neurophysiology. 91: 1457-69. PMID 14668299 DOI: 10.1152/Jn.00989.2003  0.655
2002 McIntyre CC, Thakor NV. Uncovering the mechanisms of deep brain stimulation for Parkinson's disease through functional imaging, neural recording, and neural modeling. Critical Reviews in Biomedical Engineering. 30: 249-81. PMID 12739751 DOI: 10.1615/Critrevbiomedeng.V30.I456.20  0.42
2002 McIntyre CC, Grill WM. Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal output. Journal of Neurophysiology. 88: 1592-604. PMID 12364490 DOI: 10.1152/Jn.2002.88.4.1592  0.575
2002 McIntyre CC, Richardson AG, Grill WM. Modeling the excitability of mammalian nerve fibers: influence of afterpotentials on the recovery cycle. Journal of Neurophysiology. 87: 995-1006. PMID 11826063 DOI: 10.1152/Jn.00353.2001  0.501
2002 McIntyre CC, Grill WM, Sherman DL, Thakor NV. Model-based analysis of deep brain stimulation of the thalamus Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 3: 2047-2048.  0.402
2001 McIntyre CC, Grill WM. Finite element analysis of the current-density and electric field generated by metal microelectrodes. Annals of Biomedical Engineering. 29: 227-35. PMID 11310784 DOI: 10.1114/1.1352640  0.561
2001 Grill WM, McIntyre CC. Extracellular excitation of central neurons: Implications for the mechanisms of deep brain stimulation Thalamus and Related Systems. 1: 269-277. DOI: 10.1016/S1472-9288(01)00025-5  0.653
2001 McIntyre CC, Grill WM. Model-based design of stimulus trains for selective microstimulation of targeted neuronal populations Annual Reports of the Research Reactor Institute, Kyoto University. 1: 806-809.  0.387
2000 Richardson AG, McIntyre CC, Grill WM. Modelling the effects of electric fields on nerve fibres: influence of the myelin sheath. Medical & Biological Engineering & Computing. 38: 438-46. PMID 10984943 DOI: 10.1007/BF02345014  0.527
2000 McIntyre CC, Grill WM. Selective microstimulation of central nervous system neurons. Annals of Biomedical Engineering. 28: 219-33. PMID 10784087 DOI: 10.1114/1.262  0.578
2000 McIntyre CC, Grill WM. Current density and electric field analysis of microelectrodes using finite element modeling Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 3: 2010-2011.  0.392
1999 McIntyre CC, Grill WM. Excitation of central nervous system neurons by nonuniform electric fields. Biophysical Journal. 76: 878-88. PMID 9929489 DOI: 10.1016/S0006-3495(99)77251-6  0.546
1998 McIntyre CC, Grill WM. Sensitivity analysis of a model of mammalian neural membrane. Biological Cybernetics. 79: 29-37. PMID 9742675 DOI: 10.1007/S004220050455  0.469
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