Julian Knight - Publications

Affiliations: 
University of Oxford, Oxford, United Kingdom 
Area:
HLA, Genetics of inflammation
Website:
http://www.well.ox.ac.uk/jknight/

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Chong AY, Brenner N, Jimenez-Kaufmann A, Cortes A, Hill M, Littlejohns TJ, Gilchrist JJ, Fairfax BP, Knight JC, Hodel F, Fellay J, McVean G, Moreno-Estrada A, Waterboer T, Hill AVS, et al. A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy. American Journal of Human Genetics. PMID 38232728 DOI: 10.1016/j.ajhg.2023.12.013  0.314
2023 Akbari P, Vuckovic D, Stefanucci L, Jiang T, Kundu K, Kreuzhuber R, Bao EL, Collins JH, Downes K, Grassi L, Guerrero JA, Kaptoge S, Knight JC, Meacham S, Sambrook J, et al. A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology. Nature Communications. 14: 5023. PMID 37596262 DOI: 10.1038/s41467-023-40679-y  0.366
2023 Brown AC, Cohen CJ, Mielczarek O, Migliorini G, Costantino F, Allcock A, Davidson C, Elliott KS, Fang H, Lledó Lara A, Martin AC, Osgood JA, Sanniti A, Scozzafava G, Vecellio M, ... ... Knight JC, et al. Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis. Cell Genomics. 3: 100306. PMID 37388915 DOI: 10.1016/j.xgen.2023.100306  0.399
2023 Pairo-Castineira E, Rawlik K, Bretherick AD, Qi T, Wu Y, Nassiri I, McConkey GA, Zechner M, Klaric L, Griffiths F, Oosthuyzen W, Kousathanas A, Richmond A, Millar J, Russell CD, ... ... Knight J, et al. GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. Nature. PMID 37198478 DOI: 10.1038/s41586-023-06034-3  0.346
2022 Gilchrist JJ, Makino S, Naranbhai V, Sharma PK, Koturan S, Tong O, Taylor CA, Watson RA, de Los Aires AV, Cooper R, Lau E, Danielli S, Hameiri-Bowen D, Lee W, Ng E, ... ... Knight JC, et al. Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity. Nature Communications. 13: 4073. PMID 35835762 DOI: 10.1038/s41467-022-31626-4  0.402
2022 Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, ... ... Knight J, et al. Whole genome sequencing reveals host factors underlying critical Covid-19. Nature. PMID 35255492 DOI: 10.1038/s41586-022-04576-6  0.358
2021 Downes DJ, Cross AR, Hua P, Roberts N, Schwessinger R, Cutler AJ, Munis AM, Brown J, Mielczarek O, de Andrea CE, Melero I, Gill DR, Hyde SC, Knight JC, et al. Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus. Nature Genetics. 53: 1606-1615. PMID 34737427 DOI: 10.1038/s41588-021-00955-3  0.331
2021 Võsa U, Claringbould A, Westra HJ, Bonder MJ, Deelen P, Zeng B, Kirsten H, Saha A, Kreuzhuber R, Yazar S, Brugge H, Oelen R, de Vries DH, van der Wijst MGP, Kasela S, ... ... Knight JC, et al. Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nature Genetics. PMID 34475573 DOI: 10.1038/s41588-021-00913-z  0.36
2020 Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Fourman MH, Russell CD, Furniss J, Richmond A, Gountouna E, Wrobel N, Harrison D, ... ... Knight J, et al. Genetic mechanisms of critical illness in Covid-19. Nature. PMID 33307546 DOI: 10.1038/s41586-020-03065-y  0.353
2020 Vuckovic D, Bao EL, Akbari P, Lareau CA, Mousas A, Jiang T, Chen MH, Raffield LM, Tardaguila M, Huffman JE, Ritchie SC, Megy K, Ponstingl H, Penkett CJ, Albers PK, ... ... Knight JC, et al. The Polygenic and Monogenic Basis of Blood Traits and Diseases. Cell. 182: 1214-1231.e11. PMID 32888494 DOI: 10.1016/J.Cell.2020.08.008  0.304
2020 Williams LM, McCann FE, Cabrita MA, Layton T, Cribbs A, Knezevic B, Fang H, Knight J, Zhang M, Fischer R, Bonham S, Steenbeek LM, Yang N, Sood M, Bainbridge C, et al. Identifying collagen VI as a target of fibrotic diseases regulated by CREBBP/EP300. Proceedings of the National Academy of Sciences of the United States of America. PMID 32759223 DOI: 10.1073/pnas.2004281117  0.384
2020 Fairfax BP, Taylor CA, Watson RA, Nassiri I, Danielli S, Fang H, Mahé EA, Cooper R, Woodcock V, Traill Z, Al-Mossawi MH, Knight JC, Klenerman P, Payne M, Middleton MR. Peripheral CD8 T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma. Nature Medicine. PMID 32042196 DOI: 10.1038/s41591-019-0734-6  0.665
2019 Al-Mossawi H, Yager N, Taylor CA, Lau E, Danielli S, de Wit J, Gilchrist J, Nassiri I, Mahe EA, Lee W, Rizvi L, Makino S, Cheeseman J, Neville M, Knight JC, et al. Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele. Nature Communications. 10: 4575. PMID 31594933 DOI: 10.1038/S41467-019-12393-1  0.725
2019 Fang H, De Wolf H, Knezevic B, Burnham KL, Osgood J, Sanniti A, Lledó Lara A, Kasela S, De Cesco S, Wegner JK, Handunnetthi L, McCann FE, Chen L, Sekine T, ... ... Knight JC, et al. A genetics-led approach defines the drug target landscape of 30 immune-related traits. Nature Genetics. PMID 31253980 DOI: 10.1038/S41588-019-0456-1  0.653
2019 Al-Mossawi H, Yager N, Taylor C, Danielli S, Gilchrist J, Nassiri I, Mahe E, Knight J, Fairfax BP, Bowness P. O32 Ankylosing spondylitis associated polymorphism of the IL7R controls expression surface and soluble IL7R-alpha during in inflammation Rheumatology. 58. DOI: 10.1093/RHEUMATOLOGY/KEZ105.031  0.662
2019 Fairfax B, Taylor C, Watson R, Nassiri I, Fang H, Mahe E, Cooper R, Danielli S, Woodcock V, Traill Z, Knight J, Payne M, Middleton M. Early peripheral T-cell responses predict oncological outcome to checkpoint immune blockade in metastatic melanoma Annals of Oncology. 30: v486-v487. DOI: 10.1093/annonc/mdz253.020  0.625
2018 Osgood JA, Knight JC. Translating GWAS in rheumatic disease: approaches to establishing mechanism and function for genetic associations with ankylosing spondylitis. Briefings in Functional Genomics. PMID 29741584 DOI: 10.1093/bfgp/ely015  0.364
2018 Gilchrist JJ, Rautanen A, Fairfax BP, Mills TC, Naranbhai V, Trochet H, Pirinen M, Muthumbi E, Mwarumba S, Njuguna P, Mturi N, Msefula CL, Gondwe EN, MacLennan JM, Chapman SJ, ... ... Knight JC, et al. Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4. Nature Communications. 9: 1014. PMID 29523850 DOI: 10.1038/s41467-017-02398-z  0.693
2018 Al-Mossawi MH, Lau E, Danielli S, Yager N, Wit Jd, Mahe E, Rizvi L, Knight J, Fairfax B, Bowness P. Genotypic Effects Of Ankylosing Spondylitis Associated Il7R Polymorphisms Are Mediated Through Monocytes In Inflammation Annals of the Rheumatic Diseases. 77: 191-191. DOI: 10.1136/Annrheumdis-2018-Eular.3704  0.432
2017 Al-Mossawi MH, Chen L, Fang H, Ridley A, de Wit J, Yager N, Hammitzsch A, Pulyakhina I, Fairfax BP, Simone D, Yi Y, Bandyopadhyay S, Doig K, Gundle R, Kendrick B, ... ... Knight JC, et al. Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis. Nature Communications. 8: 1510. PMID 29142230 DOI: 10.1038/S41467-017-01771-2  0.654
2017 Kasela S, Kisand K, Tserel L, Kaleviste E, Remm A, Fischer K, Esko T, Westra HJ, Fairfax BP, Makino S, Knight JC, Franke L, Metspalu A, Peterson P, Milani L. Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells. Plos Genetics. 13: e1006643. PMID 28248954 DOI: 10.1371/Journal.Pgen.1006643  0.704
2017 Kumar D, Puan KJ, Andiappan AK, Lee B, Westerlaken GH, Haase D, Melchiotti R, Li Z, Yusof N, Lum J, Koh G, Foo S, Yeong J, Alves AC, Pekkanen J, ... ... Knight JC, et al. A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus. Genome Medicine. 9: 18. PMID 28219444 DOI: 10.1186/s13073-017-0404-6  0.436
2016 Vince N, Li H, Ramsuran V, Naranbhai V, Duh FM, Fairfax BP, Saleh B, Knight JC, Anderson SK, Carrington M. HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region. American Journal of Human Genetics. PMID 27817866 DOI: 10.1016/j.ajhg.2016.09.023  0.67
2016 Hore V, Viñuela A, Buil A, Knight J, McCarthy MI, Small K, Marchini J. Tensor decomposition for multiple-tissue gene expression experiments. Nature Genetics. PMID 27479908 DOI: 10.1038/Ng.3624  0.443
2015 Naranbhai V, Fletcher HA, Tanner R, O'Shea MK, McShane H, Fairfax BP, Knight JC, Hill AVS. Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes. Ebiomedicine. 2: 1619-1626. PMID 28958495 DOI: 10.1016/j.ebiom.2015.09.027  0.314
2015 Naranbhai V, Fletcher HA, Tanner R, O'Shea MK, McShane H, Fairfax BP, Knight JC, Hill AV. Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes. Ebiomedicine. 2: 1619-1626. PMID 26870787 DOI: 10.1016/j.ebiom.2015.09.027  0.688
2015 Bentham J, Morris DL, Cunninghame Graham DS, Pinder CL, Tombleson P, Behrens TW, Martín J, Fairfax BP, Knight JC, Chen L, Replogle J, Syvänen AC, Rönnblom L, Graham RR, Wither JE, et al. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nature Genetics. PMID 26502338 DOI: 10.1038/Ng.3434  0.735
2015 Vecellio M, Roberts AR, Cohen CJ, Cortes A, Knight JC, Bowness P, Wordsworth BP. The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression. Annals of the Rheumatic Diseases. PMID 26452539 DOI: 10.1136/annrheumdis-2015-207490  0.368
2015 Gilchrist JJ, Mills TC, Naranbhai V, Chapman SJ, Fairfax BP, Knight JC, Williams TN, Scott JA, MacLennan CA, Rautanen A, Hill AV. Genetic variants associated with non-typhoidal Salmonella bacteraemia in African children. Lancet (London, England). 385: S13. PMID 26312835 DOI: 10.1016/S0140-6736(15)60328-2  0.652
2015 Naranbhai V, Fairfax BP, Makino S, Humburg P, Wong D, Ng E, Hill AV, Knight JC. Genomic modulators of gene expression in human neutrophils. Nature Communications. 6: 7545. PMID 26151758 DOI: 10.1038/Ncomms8545  0.742
2015 Westra HJ, Arends D, Esko T, Peters MJ, Schurmann C, Schramm K, Kettunen J, Yaghootkar H, Fairfax BP, Andiappan AK, Li Y, Fu J, Karjalainen J, Platteel M, Visschedijk M, ... ... Knight JC, et al. Cell Specific eQTL Analysis without Sorting Cells. Plos Genetics. 11: e1005223. PMID 25955312 DOI: 10.1371/Journal.Pgen.1005223  0.709
2015 Naranbhai V, Fairfax BP, Makino S, Humburg P, Wong D, Ng E, Hill AVS, Knight JC. Genomic modulators of gene expression in human neutrophils Nature Communications. 6. DOI: 10.1038/ncomms8545  0.671
2015 Naranbhai V, Fletcher HA, Tanner R, O'Shea MK, McShane H, Fairfax BP, Knight JC, Hill AVS. Distinct Ttranscriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes Ebiomedicine. DOI: 10.1016/j.ebiom.2015.09.027  0.63
2014 Knight JC. Approaches for establishing the function of regulatory genetic variants involved in disease. Genome Medicine. 6: 92. PMID 25473428 DOI: 10.1186/s13073-014-0092-4  0.369
2014 Wong D, Lee W, Humburg P, Makino S, Lau E, Naranbhai V, Fairfax BP, Chan K, Plant K, Knight JC. Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach. Genome Biology. 15: 494. PMID 25366989 DOI: 10.1186/S13059-014-0494-Z  0.729
2014 Fairfax BP, Knight JC. Genetics of gene expression in immunity to infection. Current Opinion in Immunology. 30: 63-71. PMID 25078545 DOI: 10.1016/j.coi.2014.07.001  0.701
2014 Fairfax BP, Humburg P, Makino S, Naranbhai V, Wong D, Lau E, Jostins L, Plant K, Andrews R, McGee C, Knight JC. Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression. Science (New York, N.Y.). 343: 1246949. PMID 24604202 DOI: 10.1126/Science.1246949  0.724
2014 Plant K, Fairfax BP, Makino S, Vandiedonck C, Radhakrishnan J, Knight JC. Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57. European Journal of Human Genetics : Ejhg. 22: 568-71. PMID 24193346 DOI: 10.1038/Ejhg.2013.244  0.722
2014 Simpson NH, Addis L, Brandler WM, Slonims V, Clark A, Watson J, Scerri TS, Hennessy ER, Bolton PF, Conti-Ramsden G, Fairfax BP, Knight JC, Stein J, Talcott JB, O'Hare A, et al. Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia. Developmental Medicine and Child Neurology. 56: 346-53. PMID 24117048 DOI: 10.1111/Dmcn.12294  0.611
2013 Westra HJ, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J, Christiansen MW, Fairfax BP, Schramm K, Powell JE, Zhernakova A, Zhernakova DV, Veldink JH, Van den Berg LH, Karjalainen J, ... ... Knight JC, et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics. 45: 1238-43. PMID 24013639 DOI: 10.1038/Ng.2756  0.728
2013 Trowsdale J, Knight JC. Major histocompatibility complex genomics and human disease. Annual Review of Genomics and Human Genetics. 14: 301-23. PMID 23875801 DOI: 10.1146/annurev-genom-091212-153455  0.334
2013 Bønnelykke K, Matheson MC, Pers TH, Granell R, Strachan DP, Alves AC, Linneberg A, Curtin JA, Warrington NM, Standl M, Kerkhof M, Jonsdottir I, Bukvic BK, Kaakinen M, Sleimann P, ... ... Knight JC, et al. Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nature Genetics. 45: 902-6. PMID 23817571 DOI: 10.1038/Ng.2694  0.701
2013 Knight JC. Genomic modulators of the immune response. Trends in Genetics : Tig. 29: 74-83. PMID 23122694 DOI: 10.1016/j.tig.2012.10.006  0.306
2012 Simpson PD, Moysi E, Wicks K, Sudan K, Rowland-Jones SL, McMichael AJ, Knight J, Gillespie GM. Functional differences exist between TNFα promoters encoding the common -237G SNP and the rarer HLA-B*5701-linked A variant. Plos One. 7: e40100. PMID 22808100 DOI: 10.1371/journal.pone.0040100  0.439
2012 Fairfax BP, Makino S, Radhakrishnan J, Plant K, Leslie S, Dilthey A, Ellis P, Langford C, Vannberg FO, Knight JC. Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nature Genetics. 44: 502-10. PMID 22446964 DOI: 10.1038/Ng.2205  0.722
2011 Vandiedonck C, Taylor MS, Lockstone HE, Plant K, Taylor JM, Durrant C, Broxholme J, Fairfax BP, Knight JC. Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complex. Genome Research. 21: 1042-54. PMID 21628452 DOI: 10.1101/gr.116681.110  0.732
2011 Fairfax BP, Davenport EE, Makino S, Hill AV, Vannberg FO, Knight JC. A common haplotype of the TNF receptor 2 gene modulates endotoxin tolerance. Journal of Immunology (Baltimore, Md. : 1950). 186: 3058-65. PMID 21282507 DOI: 10.4049/Jimmunol.1001791  0.666
2011 Wicks K, Knight JC. Transcriptional repression and DNA looping associated with a novel regulatory element in the final exon of the lymphotoxin-Β gene Genes and Immunity. 12: 126-135. PMID 21248773 DOI: 10.1038/gene.2010.62  0.303
2010 Paracchini S, Monaco AP, Knight JC. An allele-specific gene expression assay to test the functional basis of genetic associations. Journal of Visualized Experiments : Jove. PMID 21085102 DOI: 10.3791/2279  0.314
2010 Maugeri N, Radhakrishnan J, Knight JC. Genetic determinants of HSP70 gene expression following heat shock. Human Molecular Genetics. 19: 4939-47. PMID 20876613 DOI: 10.1093/hmg/ddq418  0.322
2010 Wong SH, Gochhait S, Malhotra D, Pettersson FH, Teo YY, Khor CC, Rautanen A, Chapman SJ, Mills TC, Srivastava A, Rudko A, Freidin MB, Puzyrev VP, Ali S, Aggarwal S, ... ... Knight JC, et al. Leprosy and the adaptation of human toll-like receptor 1. Plos Pathogens. 6: e1000979. PMID 20617178 DOI: 10.1371/Journal.Ppat.1000979  0.703
2010 Fairfax BP, Vannberg FO, Radhakrishnan J, Hakonarson H, Keating BJ, Hill AV, Knight JC. An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6. Human Molecular Genetics. 19: 720-30. PMID 19942621 DOI: 10.1093/Hmg/Ddp530  0.697
2010 Vandiedonck C, Taylor M, Lockstone H, Plant K, Taylor J, Fairfax B, Durrant C, Broxholme J, Knight J. The First Transcriptional Map of the Human Major Histocompatibility Complex Reveals New Transcripts and Haplotype-specific Pattern of Expression Clinical Immunology. 135: S9. DOI: 10.1016/J.Clim.2010.03.035  0.671
2009 Dennis MY, Paracchini S, Scerri TS, Prokunina-Olsson L, Knight JC, Wade-Martins R, Coggill P, Beck S, Green ED, Monaco AP. A common variant associated with dyslexia reduces expression of the KIAA0319 gene. Plos Genetics. 5: e1000436. PMID 19325871 DOI: 10.1371/Journal.Pgen.1000436  0.383
2007 Knight J. Polymorphisms in tumor necrosis factor and other cytokines as risks for infectious diseases and the septic syndrome. Current Infectious Disease Reports. 3: 427-39. PMID 24395481 DOI: 10.1007/s11908-007-1010-3  0.467
2007 Hull J, Campino S, Rowlands K, Chan MS, Copley RR, Taylor MS, Rockett K, Elvidge G, Keating B, Knight J, Kwiatkowski D. Identification of common genetic variation that modulates alternative splicing. Plos Genetics. 3: e99. PMID 17571926 DOI: 10.1371/Journal.Pgen.0030099  0.414
2006 Knight JC. Analysis of allele-specific gene expression. Methods in Molecular Biology (Clifton, N.J.). 338: 153-65. PMID 16888357 DOI: 10.1385/1-59745-097-9:153  0.358
2005 Knight JC. Regulatory polymorphisms underlying complex disease traits. Journal of Molecular Medicine (Berlin, Germany). 83: 97-109. PMID 15592805 DOI: 10.1007/s00109-004-0603-7  0.382
2004 Knight JC, Keating BJ, Kwiatkowski DP. Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1. Nature Genetics. 36: 394-9. PMID 15052269 DOI: 10.1038/ng1331  0.342
2003 Knight JC, Keating BJ, Rockett KA, Kwiatkowski DP. In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading. Nature Genetics. 33: 469-75. PMID 12627232 DOI: 10.1038/ng1124  0.313
2003 Knight JC. Functional implications of genetic variation in non-coding DNA for disease susceptibility and gene regulation. Clinical Science (London, England : 1979). 104: 493-501. PMID 12513691 DOI: 10.1042/CS20020304  0.326
1999 Knight JC, Kwiatkowski D. Inherited variability of tumor necrosis factor production and susceptibility to infectious disease Proceedings of the Association of American Physicians. 111: 290-298. PMID 10417736 DOI: 10.1046/j.1525-1381.1999.99237.x  0.323
1999 Knight JC, Udalova I, Hill AVS, Greenwood BM, Peshu N, Marsh K, Kwiatkowski D. A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria Nature Genetics. 22: 145-150. PMID 10369255 DOI: 10.1038/9649  0.312
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