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Nikunj M. Shukla, Ph.D. - Publications

Affiliations: 
2011 Medicinal Chemistry University of Kansas, Lawrence, KS, United States 
Area:
Pharmaceutical Chemistry, Pharmacy, Immunology
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30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Saito T, Shukla NM, Sato-Kaneko F, Sako Y, Hosoya T, Yao S, Lao FS, Messer K, Pu M, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity. Acs Chemical Biology. PMID 34985883 DOI: 10.1021/acschembio.1c00883  0.453
2021 Saito T, Sako Y, Sato-Kaneko F, Hosoya T, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, et al. Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge. Frontiers in Immunology. 12: 701445. PMID 34650551 DOI: 10.3389/fimmu.2021.701445  0.521
2021 Shukla NM, Chan M, Lao FS, Chu PJ, Belsuzarri M, Yao S, Nan J, Sato-Kaneko F, Saito T, Hayashi T, Corr M, Carson DA, Cottam HB. Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-κB activation. Bioorganic & Medicinal Chemistry. 43: 116242. PMID 34274759 DOI: 10.1016/j.bmc.2021.116242  0.492
2021 Sato-Kaneko F, Yao S, Lao FS, Nan J, Shpigelman J, Cheng A, Saito T, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Molina AJ, Corr M, Hayashi T, et al. Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34078669 DOI: 10.1073/pnas.2025718118  0.43
2020 Sato-Kaneko F, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Chu PJ, Burkhart D, Schoener R, Matsutani T, Carson DA, Corr M, et al. A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity. Frontiers in Immunology. 11: 1207. PMID 32636840 DOI: 10.3389/fimmu.2020.01207  0.34
2019 Chan M, Lao FS, Chu PJ, Shpigelman J, Yao S, Nan J, Sato-Kaneko F, Li V, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM. Structure-Activity Relationship Studies to Identify Affinity Probes in Bis-aryl Sulfonamides that Prolong Immune Stimuli. Journal of Medicinal Chemistry. PMID 31603681 DOI: 10.1021/acs.jmedchem.9b00870  0.424
2018 Shukla NM, Chan M, Hayashi T, Carson DA, Cottam HB. Recent Advances and Perspectives in Small-molecule TLR Ligands and Their Modulators. Acs Medicinal Chemistry Letters. 9: 1156-1159. PMID 30613317 DOI: 10.1021/acsmedchemlett.8b00566  0.531
2018 Zhang Z, Ohto U, Shibata T, Taoka M, Yamauchi Y, Sato R, Shukla NM, David SA, Isobe T, Miyake K, Shimizu T. Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands. Cell Reports. 25: 3371-3381.e5. PMID 30566863 DOI: 10.1016/J.Celrep.2018.11.081  0.662
2018 Sato-Kaneko F, Wang X, Yao S, Hosoya T, Lao FS, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Carson DA, Corr M, Hayashi T. Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy. Biomed Research International. 2018: 8091283. PMID 30406141 DOI: 10.1155/2018/8091283  0.332
2018 Yoo E, Salyer ACD, Brush MJH, Li Y, Trautman KL, Shukla NM, De Beuckelaer A, Lienenklaus S, Deswarte K, Lambrecht B, De Geest BG, David SA. Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue. Bioconjugate Chemistry. PMID 29969553 DOI: 10.1021/Acs.Bioconjchem.8B00386  0.638
2018 Shukla NM, Arimoto KI, Yao S, Fan JB, Zhang Y, Sato-Kaneko F, Lao FS, Hosoya T, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T, Zhang DE, Corr M. Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants. Slas Discovery : Advancing Life Sciences R & D. 2472555218774308. PMID 29751735 DOI: 10.1177/2472555218774308  0.403
2017 Chan M, Kakitsubata Y, Hayashi T, Ahmadi A, Yao S, Shukla NM, Oyama SY, Baba A, Nguyen B, Corr M, Suda Y, Carson DA, Cottam HB, Wakao M. Structure-activity relationship studies of pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands. Journal of Medicinal Chemistry. PMID 29049886 DOI: 10.1021/acs.jmedchem.7b00797  0.514
2017 Chan M, Ahmadi A, Yao S, Sato-Kaneko F, Messer K, Pu M, Nguyen B, Hayashi T, Corr M, Carson D, Cottam HB, Shukla N. Identification of Biologically Active Pyrimido[5,4-b] indoles that Prolong NF-κB Activation Without Intrinsic Activity. Acs Combinatorial Science. PMID 28657707 DOI: 10.1021/Acscombsci.7B00080  0.454
2016 Nuhn L, Vanparijs N, De Beuckelaer A, Lybaert L, Verstraete G, Deswarte K, Lienenklaus S, Shukla NM, Salyer AC, Lambrecht BN, Grooten J, David SA, De Koker S, De Geest BG. pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27382168 DOI: 10.1073/Pnas.1600816113  0.665
2016 Beesu M, Caruso G, Salyer AC, Shukla NM, Khetani KK, Smith LJ, Fox LM, Tanji H, Ohto U, Shimizu T, David SA. Identification of a Human Toll-like Receptor (TLR) 8-specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles. Journal of Medicinal Chemistry. PMID 26966993 DOI: 10.1021/Acs.Jmedchem.6B00023  0.686
2015 Ganapathi L, Van Haren S, Dowling DJ, Bergelson I, Shukla NM, Malladi SS, Balakrishna R, Tanji H, Ohto U, Shimizu T, David SA, Levy O. The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes. Plos One. 10: e0134640. PMID 26274907 DOI: 10.1371/Journal.Pone.0134640  0.644
2013 Salunke DB, Connelly SW, Shukla NM, Hermanson AR, Fox LM, David SA. Design and development of stable, water-soluble, human Toll-like receptor 2 specific monoacyl lipopeptides as candidate vaccine adjuvants. Journal of Medicinal Chemistry. 56: 5885-900. PMID 23795818 DOI: 10.1021/Jm400620G  0.706
2012 Shukla NM, Salunke DB, Balakrishna R, Mutz CA, Malladi SS, David SA. Potent adjuvanticity of a pure TLR7-agonistic imidazoquinoline dendrimer. Plos One. 7: e43612. PMID 22952720 DOI: 10.1371/Journal.Pone.0043612  0.725
2012 Shukla NM, Salunke DB, Yoo E, Mutz CA, Balakrishna R, David SA. Antibacterial activities of Groebke-Blackburn-Bienaymé-derived imidazo[1,2-a]pyridin-3-amines. Bioorganic & Medicinal Chemistry. 20: 5850-63. PMID 22925449 DOI: 10.1016/J.Bmc.2012.07.052  0.562
2012 Salunke DB, Yoo E, Shukla NM, Balakrishna R, Malladi SS, Serafin KJ, Day VW, Wang X, David SA. Structure-activity relationships in human Toll-like receptor 8-active 2,3-diamino-furo[2,3-c]pyridines. Journal of Medicinal Chemistry. 55: 8137-51. PMID 22924757 DOI: 10.1021/Jm301066H  0.668
2012 Salunke DB, Shukla NM, Yoo E, Crall BM, Balakrishna R, Malladi SS, David SA. Structure-activity relationships in human Toll-like receptor 2-specific monoacyl lipopeptides. Journal of Medicinal Chemistry. 55: 3353-63. PMID 22385476 DOI: 10.1021/Jm3000533  0.651
2012 Shukla NM, Mutz CA, Malladi SS, Warshakoon HJ, Balakrishna R, David SA. Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines. Journal of Medicinal Chemistry. 55: 1106-16. PMID 22239408 DOI: 10.1021/Jm2010207  0.729
2011 Shukla NM, Malladi SS, Day V, David SA. Preliminary evaluation of a 3H imidazoquinoline library as dual TLR7/TLR8 antagonists. Bioorganic & Medicinal Chemistry. 19: 3801-11. PMID 21620714 DOI: 10.1016/J.Bmc.2011.04.052  0.689
2011 Shukla NM, Lewis TC, Day TP, Mutz CA, Ukani R, Hamilton CD, Balakrishna R, David SA. Toward self-adjuvanting subunit vaccines: model peptide and protein antigens incorporating covalently bound toll-like receptor-7 agonistic imidazoquinolines. Bioorganic & Medicinal Chemistry Letters. 21: 3232-6. PMID 21549593 DOI: 10.1016/J.Bmcl.2011.04.050  0.656
2011 Day TP, Sil D, Shukla NM, Anbanandam A, Day VW, David SA. Imbuing aqueous solubility to amphotericin B and nystatin with a vitamin. Molecular Pharmaceutics. 8: 297-301. PMID 21141891 DOI: 10.1021/Mp100363F  0.498
2010 Shukla NM, Mutz CA, Ukani R, Warshakoon HJ, Moore DS, David SA. Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorganic & Medicinal Chemistry Letters. 20: 6384-6. PMID 20933417 DOI: 10.1016/J.Bmcl.2010.09.093  0.62
2010 Shukla NM, Malladi SS, Mutz CA, Balakrishna R, David SA. Structure-activity relationships in human toll-like receptor 7-active imidazoquinoline analogues. Journal of Medicinal Chemistry. 53: 4450-65. PMID 20481492 DOI: 10.1021/Jm100358C  0.733
2010 Hood JD, Warshakoon HJ, Kimbrell MR, Shukla NM, Malladi SS, Wang X, David SA. Immunoprofiling toll-like receptor ligands: Comparison of immunostimulatory and proinflammatory profiles in ex vivo human blood models. Human Vaccines. 6: 322-35. PMID 20372068 DOI: 10.4161/Hv.6.4.10866  0.735
2009 Shukla NM, Kimbrell MR, Malladi SS, David SA. Regioisomerism-dependent TLR7 agonism and antagonism in an imidazoquinoline. Bioorganic & Medicinal Chemistry Letters. 19: 2211-4. PMID 19285861 DOI: 10.1016/J.Bmcl.2009.02.100  0.714
2009 Warshakoon HJ, Hood JD, Kimbrell MR, Malladi S, Wu WY, Shukla NM, Agnihotri G, Sil D, David SA. Potential adjuvantic properties of innate immune stimuli. Human Vaccines. 5: 381-94. PMID 19270494 DOI: 10.4161/Hv.5.6.8175  0.708
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