Hui-Lin Pan, Ph.D., M.D. - Publications

Affiliations: 
University of Texas MD Anderson Cancer Center, Houston, TX, United States 

73 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Huang Y, Chen H, Chen SR, Pan HL. Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via α1- and α2-Adrenergic Receptors. Acs Chemical Neuroscience. PMID 36930958 DOI: 10.1021/acschemneuro.2c00780  0.303
2022 Ghosh K, Zhang GF, Chen H, Chen SR, Pan HL. Cannabinoid CB2 receptors are upregulated via bivalent histone modifications and control primary afferent input to the spinal cord in neuropathic pain. The Journal of Biological Chemistry. 101999. PMID 35500651 DOI: 10.1016/j.jbc.2022.101999  0.311
2021 Huang Y, Chen SR, Pan HL. Calcineurin Regulates Synaptic Plasticity and Nociceptive Transmissionat the Spinal Cord Level. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 10738584211046888. PMID 34791930 DOI: 10.1177/10738584211046888  0.313
2020 Huang Y, Chen SR, Chen H, Luo Y, Pan HL. Calcineurin inhibition causes α2δ-1-mediated tonic activation of synaptic NMDA receptors and pain hypersensitivity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32269108 DOI: 10.1523/JNEUROSCI.0282-20.2020  0.314
2020 Zhou J, Shao J, Chen S, Li D, Pan H. Chronic Stress Induces Persistent Hypertension and Increases NMDA Receptor Activity in the Paraventricular Nucleus in Borderline Hypertensive Rats The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03968  0.329
2019 Zou G, Chen Q, Chen K, Zuo X, Ge Y, Hou Y, Pan T, Pan H, Liu D, Zhang L, Xiong W. Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABA Receptors. Iscience. 19: 634-646. PMID 31450193 DOI: 10.1016/J.Isci.2019.08.018  0.301
2019 Ma H, Chen SR, Chen H, Pan HL. Endogenous AT1 receptor-protein kinase C activity in the hypothalamus augments glutamatergic input and sympathetic outflow in hypertension. The Journal of Physiology. PMID 31241170 DOI: 10.1113/Jp278427  0.365
2019 Deng M, Chen SR, Pan HL. Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain. Cellular and Molecular Life Sciences : Cmls. PMID 30788514 DOI: 10.1007/S00018-019-03047-Y  0.407
2019 Huang Y, Chen SR, Chen H, Pan HL. Endogenous TRPA1 and TRPV1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain. Journal of Neurochemistry. PMID 30716174 DOI: 10.1111/jnc.14677  0.351
2019 Ganugula R, Deng M, Arora M, Pan HL, Kumar MNVR. Polyester nanoparticle encapsulation mitigates paclitaxel-induced peripheral neuropathy. Acs Chemical Neuroscience. PMID 30609902 DOI: 10.1021/Acschemneuro.8B00703  0.339
2018 Deng M, Chen SR, Chen H, Luo Y, Dong Y, Pan HL. Mitogen-Activated Protein Kinase Signaling Mediates Opioid-induced Presynaptic NMDA Receptor Activation and Analgesic Tolerance. Journal of Neurochemistry. PMID 30444263 DOI: 10.1111/Jnc.14628  0.399
2018 Chen Y, Chen SR, Chen H, Zhang J, Pan HL. Increased α2δ-1-NMDA receptor coupling potentiates glutamatergic input to spinal dorsal horn neurons in chemotherapy-induced neuropathic pain. Journal of Neurochemistry. PMID 30431158 DOI: 10.1111/jnc.14627  0.313
2018 Dampney RA, Michelini LC, Li DP, Pan HL. Regulation of sympathetic vasomotor activity by the hypothalamic paraventricular nucleus in normotensive and hypertensive states. American Journal of Physiology. Heart and Circulatory Physiology. PMID 30095973 DOI: 10.1152/Ajpheart.00216.2018  0.37
2017 Xie JD, Chen SR, Pan HL. Presynaptic mGluR5 receptor controls glutamatergic input through protein kinase C-NMDA receptors in paclitaxel-induced neuropathic pain. The Journal of Biological Chemistry. PMID 29074619 DOI: 10.1074/jbc.M117.818476  0.334
2017 Zhang X, Chen S, Chen H, Pan H, Zhao Y. Inhibition of β-ARK1 Ameliorates Morphine-induced Tolerance and Hyperalgesia Via Modulating the Activity of Spinal NMDA Receptors. Molecular Neurobiology. PMID 28975565 DOI: 10.1007/S12035-017-0780-3  0.35
2017 Li DP, Zhou JJ, Zhang J, Pan HL. CaMKII Regulates Synaptic NMDA Receptor Activity of Hypothalamic Presympathetic Neurons and Sympathetic Outflow in Hypertension. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28972129 DOI: 10.1523/JNEUROSCI.2141-17.2017  0.321
2017 Chen SR, Jin XG, Pan HL. Endogenous nitric oxide inhibits spinal NMDA receptor activity pain hypersensitivity induced by nerve injury. Neuropharmacology. PMID 28754372 DOI: 10.1016/j.neuropharm.2017.07.023  0.327
2017 Xie JD, Chen SR, Chen H, Pan HL. Bortezomib induces neuropathic pain through protein kinase C-mediated activation of presynaptic NMDA receptors in the spinal cord. Neuropharmacology. PMID 28663117 DOI: 10.1016/j.neuropharm.2017.06.027  0.331
2017 Guan X, Zhang J, Li Q, Pan H, Yan J. Functional Coupling of BK Channels to NMDA Receptors in Hippocampal Dentate Gyrus Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.634  0.311
2016 Xie JD, Chen SR, Chen H, Zeng WA, Pan HL. Presynaptic N-Methyl-D-Aspartate (NMDA) Receptor Activity Is Increased Through Protein Kinase C in Paclitaxel-Induced Neuropathic Pain. The Journal of Biological Chemistry. PMID 27458019 DOI: 10.1074/jbc.M116.732347  0.335
2016 Pan H, Chen S, Laumet G, Zhang Y. Transcriptional Regulation of Potassium Channel Expression by G9a in Neuropathic Pain Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.3237  0.327
2016 Zhou M, Bavencoffe A, Pan H. Nitric Oxide Inhibits High Voltage-Activated Calcium Channels through S-Nitrosylation Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.2371  0.326
2015 Zhang Y, Laumet G, Chen SR, Hittelman WN, Pan HL. Pannexin-1 Up-regulation in the Dorsal Root Ganglion Contributes to Neuropathic Pain Development. The Journal of Biological Chemistry. 290: 14647-55. PMID 25925949 DOI: 10.1074/Jbc.M115.650218  0.37
2015 Wu Z, Kim ER, Sun H, Xu Y, Mangieri LR, Li DP, Pan HL, Xu Y, Arenkiel BR, Tong Q. GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 3312-8. PMID 25716832 DOI: 10.1523/Jneurosci.3720-14.2015  0.317
2014 Chen SR, Zhou HY, Byun HS, Chen H, Pan HL. Casein kinase II regulates N-methyl-D-aspartate receptor activity in spinal cords and pain hypersensitivity induced by nerve injury. The Journal of Pharmacology and Experimental Therapeutics. 350: 301-12. PMID 24898266 DOI: 10.1124/jpet.114.215855  0.307
2014 Li DP, Zhu LH, Pachuau J, Lee HA, Pan HL. mGluR5 Upregulation increases excitability of hypothalamic presympathetic neurons through NMDA receptor trafficking in spontaneously hypertensive rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 4309-17. PMID 24647951 DOI: 10.1523/JNEUROSCI.4295-13.2014  0.311
2014 Hu YM, Chen SR, Chen H, Pan HL. Casein kinase II inhibition reverses pain hypersensitivity and potentiated spinal N-methyl-D-aspartate receptor activity caused by calcineurin inhibitor. The Journal of Pharmacology and Experimental Therapeutics. 349: 239-47. PMID 24610957 DOI: 10.1124/jpet.113.212563  0.324
2014 Chen SR, Hu YM, Chen H, Pan HL. Calcineurin inhibitor induces pain hypersensitivity by potentiating pre- and postsynaptic NMDA receptor activity in spinal cords. The Journal of Physiology. 592: 215-27. PMID 24081160 DOI: 10.1113/jphysiol.2013.263814  0.346
2014 Pan H, Chen S, Hu Y, Chen H. 301) CK2 mediates increased synaptic NMDA receptor activity and pain hypersensitivity induced by calcineurin inhibitor The Journal of Pain. 15. DOI: 10.1016/J.Jpain.2014.01.211  0.341
2013 Chen SR, Zhou HY, Byun HS, Pan HL. Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 347: 765-72. PMID 24030012 DOI: 10.1124/jpet.113.208363  0.321
2013 Ye ZY, Li DP, Pan HL. Regulation of Hypothalamic Presympathetic Neurons and Sympathetic Outflow by Group II Metabotropic Glutamate Receptors in Spontaneously Hypertensive Rats. Hypertension. 62: 255-62. PMID 23716583 DOI: 10.1161/HYPERTENSIONAHA.113.01466  0.472
2013 Ye ZY, Li DP, Pan HL. Response to glutamate receptors and presympathetic neuronal hyperactivity of the central nervous system in hypertension Hypertension. 62: e34. DOI: 10.1161/HYPERTENSIONAHA.113.02127  0.417
2012 Zhou HY, Chen SR, Byun HS, Chen H, Li L, Han HD, Lopez-Berestein G, Sood AK, Pan HL. N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain. The Journal of Biological Chemistry. 287: 33853-64. PMID 22854961 DOI: 10.1074/Jbc.M112.395830  0.301
2012 Ye ZY, Li DP, Byun HS, Li L, Pan HL. NKCC1 upregulation disrupts chloride homeostasis in the hypothalamus and increases neuronal activity-sympathetic drive in hypertension. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8560-8. PMID 22723696 DOI: 10.1523/JNEUROSCI.1346-12.2012  0.406
2012 Zhao YL, Chen SR, Chen H, Pan HL. Chronic opioid potentiates presynaptic but impairs postsynaptic N-methyl-D-aspartic acid receptor activity in spinal cords: implications for opioid hyperalgesia and tolerance. The Journal of Biological Chemistry. 287: 25073-85. PMID 22679016 DOI: 10.1074/Jbc.M112.378737  0.407
2012 Ye ZY, Li L, Li DP, Pan HL. Casein kinase 2-mediated synaptic GluN2A up-regulation increases N-methyl-D-aspartate receptor activity and excitability of hypothalamic neurons in hypertension. The Journal of Biological Chemistry. 287: 17438-46. PMID 22474321 DOI: 10.1074/jbc.M111.331165  0.469
2012 Li DP, Byan HS, Pan HL. Switch to glutamate receptor 2-lacking AMPA receptors increases neuronal excitability in hypothalamus and sympathetic drive in hypertension. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 372-80. PMID 22219297 DOI: 10.1523/JNEUROSCI.3222-11.2012  0.315
2012 Li L, Cao XH, Chen SR, Han HD, Lopez-Berestein G, Sood AK, Pan HL. Up-regulation of Cavβ3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain. The Journal of Biological Chemistry. 287: 6002-13. PMID 22187436 DOI: 10.1074/Jbc.M111.310110  0.327
2012 Chen Z, Yoo SH, Park YS, Kim KH, Wei S, Buhr E, Ye ZY, Pan HL, Takahashi JS. Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening. Proceedings of the National Academy of Sciences of the United States of America. 109: 101-6. PMID 22184224 DOI: 10.1073/Pnas.1118034108  0.33
2012 Pan H, Chen S, Zhao Y. Chronic morphine treatment induces differential changes in presynaptic and postsynaptic NMDA receptor activity in the spinal cord The Journal of Pain. 13. DOI: 10.1016/J.Jpain.2012.01.223  0.367
2011 Jin XG, Chen SR, Cao XH, Li L, Pan HL. Nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons. The Journal of Biological Chemistry. 286: 33190-202. PMID 21813646 DOI: 10.1074/jbc.M111.270967  0.317
2011 Ye ZY, Li DP, Li L, Pan HL. Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 8271-9. PMID 21632948 DOI: 10.1523/JNEUROSCI.1147-11.2011  0.468
2011 Zhou HY, Chen SR, Chen H, Pan HL. Functional plasticity of group II metabotropic glutamate receptors in regulating spinal excitatory and inhibitory synaptic input in neuropathic pain. The Journal of Pharmacology and Experimental Therapeutics. 336: 254-64. PMID 20923868 DOI: 10.1124/jpet.110.173112  0.317
2010 Cao XH, Byun HS, Chen SR, Cai YQ, Pan HL. Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor. Journal of Neurochemistry. 114: 1460-75. PMID 20557422 DOI: 10.1111/J.1471-4159.2010.06863.X  0.359
2010 Li DP, Chen SR, Pan HL. Adenosine inhibits paraventricular pre-sympathetic neurons through ATP-dependent potassium channels. Journal of Neurochemistry. 113: 530-42. PMID 20096091 DOI: 10.1111/j.1471-4159.2010.06618.x  0.302
2009 Zhang HM, Chen SR, Cai YQ, Richardson TE, Driver LC, Lopez-Berestein G, Pan HL. Signaling mechanisms mediating muscarinic enhancement of GABAergic synaptic transmission in the spinal cord. Neuroscience. 158: 1577-88. PMID 19110040 DOI: 10.1016/J.Neuroscience.2008.11.039  0.337
2009 Yuan WX, Chen SR, Chen H, Pan HL. Stimulation of alpha(1)-adrenoceptors reduces glutamatergic synaptic input from primary afferents through GABA(A) receptors and T-type Ca(2+) channels. Neuroscience. 158: 1616-24. PMID 19068225 DOI: 10.1016/J.Neuroscience.2008.11.022  0.392
2009 Zhang HM, Chen SR, Pan HL. Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain. Neuroscience. 158: 875-84. PMID 19017536 DOI: 10.1016/J.Neuroscience.2008.10.042  0.414
2009 Zhou HY, Chen SR, Chen H, Pan HL. The glutamatergic nature of TRPV1-expressing neurons in the spinal dorsal horn. Journal of Neurochemistry. 108: 305-18. PMID 19012737 DOI: 10.1111/j.1471-4159.2008.05772.x  0.308
2008 Zhou HY, Chen SR, Chen H, Pan HL. Sustained inhibition of neurotransmitter release from nontransient receptor potential vanilloid type 1-expressing primary afferents by mu-opioid receptor activation-enkephalin in the spinal cord. The Journal of Pharmacology and Experimental Therapeutics. 327: 375-82. PMID 18669865 DOI: 10.1124/jpet.108.141226  0.317
2008 Li DP, Yang Q, Pan HM, Pan HL. Pre- and postsynaptic plasticity underlying augmented glutamatergic inputs to hypothalamic presympathetic neurons in spontaneously hypertensive rats. The Journal of Physiology. 586: 1637-47. PMID 18238817 DOI: 10.1113/Jphysiol.2007.149732  0.306
2008 Zhou HY, Zhang HM, Chen SR, Pan HL. Increased C-fiber nociceptive input potentiates inhibitory glycinergic transmission in the spinal dorsal horn. The Journal of Pharmacology and Experimental Therapeutics. 324: 1000-10. PMID 18079355 DOI: 10.1124/jpet.107.133470  0.333
2007 Yang Q, Chen SR, Li DP, Pan HL. Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleus. Neuroscience. 149: 315-27. PMID 17869444 DOI: 10.1016/J.Neuroscience.2007.08.007  0.379
2007 Chen SR, Prunean A, Pan HM, Welker KL, Pan HL. Resistance to morphine analgesic tolerance in rats with deleted transient receptor potential vanilloid type 1-expressing sensory neurons. Neuroscience. 145: 676-85. PMID 17239544 DOI: 10.1016/J.Neuroscience.2006.12.016  0.357
2007 Zhou HY, Zhang HM, Chen SR, Pan HL. Increased nociceptive input rapidly modulates spinal GABAergic transmission through endogenously released glutamate. Journal of Neurophysiology. 97: 871-82. PMID 17108089 DOI: 10.1152/jn.00964.2006  0.334
2005 Chen YP, Chen SR, Pan HL. Effect of morphine on deep dorsal horn projection neurons depends on spinal GABAergic and glycinergic tone: implications for reduced opioid effect in neuropathic pain. The Journal of Pharmacology and Experimental Therapeutics. 315: 696-703. PMID 16033910 DOI: 10.1124/jpet.105.091314  0.302
2005 Wu ZZ, Chen SR, Pan HL. Transient receptor potential vanilloid type 1 activation down-regulates voltage-gated calcium channels through calcium-dependent calcineurin in sensory neurons. The Journal of Biological Chemistry. 280: 18142-51. PMID 15746091 DOI: 10.1074/Jbc.M501229200  0.32
2005 Chen SR, Pan HL. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. The Journal of Pharmacology and Experimental Therapeutics. 312: 120-6. PMID 15375175 DOI: 10.1124/jpet.104.073817  0.32
2004 Li DP, Chen SR, Pan HL. VR1 receptor activation induces glutamate release and postsynaptic firing in the paraventricular nucleus. Journal of Neurophysiology. 92: 1807-16. PMID 15115794 DOI: 10.1152/jn.00171.2004  0.332
2004 Chen SR, Pan HL. Activation of muscarinic receptors inhibits spinal dorsal horn projection neurons: role of GABAB receptors. Neuroscience. 125: 141-8. PMID 15051153 DOI: 10.1016/j.neuroscience.2004.01.015  0.319
2004 Finnegan TF, Li DP, Chen SR, Pan HL. Activation of mu-opioid receptors inhibits synaptic inputs to spinally projecting rostral ventromedial medulla neurons. The Journal of Pharmacology and Experimental Therapeutics. 309: 476-83. PMID 14724227 DOI: 10.1124/jpet.103.064808  0.314
2002 Pan YZ, Li DP, Chen SR, Pan HL. Activation of delta-opioid receptors excites spinally projecting locus coeruleus neurons through inhibition of GABAergic inputs. Journal of Neurophysiology. 88: 2675-83. PMID 12424303 DOI: 10.1152/jn.00298.2002  0.3
2002 Li DP, Chen SR, Pan YZ, Levey AI, Pan HL. Role of presynaptic muscarinic and GABA(B) receptors in spinal glutamate release and cholinergic analgesia in rats. The Journal of Physiology. 543: 807-18. PMID 12231640 DOI: 10.1113/jphysiol.2002.020644  0.336
2001 Li X, Zhao Z, Pan H, Eisenach JC, Paqueron X. Basic Science (24) Pain Practice. 1: 92-92. DOI: 10.1111/J.1533-2500.2001.1011-24.X  0.372
2000 Chen SR, Eisenach JC, Pan HL. Intrathecal S-nitroso-N-acetylpenicillamine and L-cysteine attenuate nerve injury-induced allodynia through noradrenergic activation in rats. Neuroscience. 101: 759-65. PMID 11113324 DOI: 10.1016/S0306-4522(00)00415-2  0.372
2000 Zhao Z, Chen SR, Eisenach JC, Busija DW, Pan HL. Spinal cyclooxygenase-2 is involved in development of allodynia after nerve injury in rats. Neuroscience. 97: 743-8. PMID 10842019 DOI: 10.1016/S0306-4522(00)00052-X  0.354
1999 Eisenach JC, Lavand'homme P, Tong C, Cheng JK, Pan HL, Virtanen R, Nikkanen H, James R. Antinociceptive and hemodynamic effects of a novel alpha2-adrenergic agonist, MPV-2426, in sheep. Anesthesiology. 91: 1425-36. PMID 10551595 DOI: 10.1097/00000542-199911000-00036  0.33
1998 Lavand'homme PM, Pan H, Eisenach JC. Sex differences in spinal cholinergic analgesia following capsaicin Anesthesiology. 89. DOI: 10.1097/00000542-199809190-00099  0.324
1998 Lavand'homme PM, Pan H, Eisenach JC. Exogenous and endogenous adenosine enhances spinal morphine analgesia Anesthesiology. 89. DOI: 10.1097/00000542-199809190-00069  0.327
1997 Xu Z, Tong C, Pan HL, Cerda SE, Eisenach JC. Intravenous morphine increases release of nitric oxide from spinal cord by an alpha-adrenergic and cholinergic mechanism. Journal of Neurophysiology. 78: 2072-8. PMID 9325374 DOI: 10.1152/Jn.1997.78.4.2072  0.327
1995 Pan HL, Longhurst JC. Lack of a role of adenosine in activation of ischemically sensitive cardiac sympathetic afferents. The American Journal of Physiology. 269: H106-13. PMID 7631838 DOI: 10.1152/Ajpheart.1995.269.1.H106  0.314
1995 Pan HL, Bonham AC, Longhurst JC. Role of spinal NK1 receptors in cardiovascular responses to chemical stimulation of the gallbladder. The American Journal of Physiology. 268: H526-34. PMID 7532372 DOI: 10.1152/Ajpheart.1995.268.2.H526  0.321
1994 Pan HL, Stahl GL, Rendig SV, Carretero OA, Longhurst JC. Endogenous BK stimulates ischemically sensitive abdominal visceral C fiber afferents through kinin B2 receptors. The American Journal of Physiology. 267: H2398-406. PMID 7810739 DOI: 10.1152/Ajpheart.1994.267.6.H2398  0.307
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