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Brian H. Shirts, Ph.D. - Publications

Affiliations: 
2006 University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Genetics, Clinical Psychology, Immunology, Pathology
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Sokolova AO, Shirts BH, Konnick EQ, Tsai GJ, Goulart BHL, Montgomery B, Pritchard CC, Yu EY, Cheng HH. Complexities of Next-Generation Sequencing in Solid Tumors: Case Studies. Journal of the National Comprehensive Cancer Network : Jnccn. 18: 1150-1155. PMID 32886903 DOI: 10.6004/Jnccn.2020.7569  0.328
2020 Makhnoon S, Bowen DJ, Shirts BH, Fullerton SM, Meischke HW, Larson EB, Ralston JD, Leppig K, Crosslin DR, Veenstra D, Jarvik GP. Relationship between genetic knowledge and familial communication of CRC risk and intent to communicate CRCP genetic information: insights from FamilyTalk eMERGE III. Translational Behavioral Medicine. PMID 32579152 DOI: 10.1093/Tbm/Ibaa054  0.329
2020 Tsai GJ, Chen AT, Garrett LT, Burke W, Bowen DJ, Shirts BH. Exploring relatives' perceptions of participation, ethics, and communication in a patient-driven study for hereditary cancer variant reclassification. Journal of Genetic Counseling. PMID 31916645 DOI: 10.1002/Jgc4.1215  0.301
2020 Dines JN, Shirts BH, Slavin TP, Walsh T, King MC, Fowler DM, Pritchard CC. Systematic misclassification of missense variants in BRCA1 and BRCA2 "coldspots". Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 31911673 DOI: 10.1038/S41436-019-0740-6  0.319
2019 Gelman H, Dines JN, Berg J, Berger AH, Brnich S, Hisama FM, James RG, Rubin AF, Shendure J, Shirts B, Fowler DM, Starita LM. Recommendations for the collection and use of multiplexed functional data for clinical variant interpretation. Genome Medicine. 11: 85. PMID 31862013 DOI: 10.1186/S13073-019-0698-7  0.353
2019 Casadei S, Gulsuner S, Shirts BH, Mandell JB, Kortbawi HM, Norquist BS, Swisher EM, Lee MK, Goldberg Y, O'Connor R, Tan Z, Pritchard CC, King MC, Walsh T. Characterization of splice-altering mutations in inherited predisposition to cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 31843900 DOI: 10.1073/Pnas.1915608116  0.322
2019 Niu X, Amendola LM, Hart R, Bennette CS, Heagerty P, Horike-Pyne M, Trinidad SB, Rosenthal EA, Comstock B, Nefcy C, Hisama FM, Bennett RL, Grady WM, Gallego CJ, Tarczy-Hornoch P, ... ... Shirts BH, et al. Clinical exome sequencing vs. usual care for hereditary colorectal cancer diagnosis: A pilot comparative effectiveness study. Contemporary Clinical Trials. 84: 105820. PMID 31400517 DOI: 10.1016/J.Cct.2019.105820  0.351
2019 Amendola LM, Hart MR, Bennett RL, Horike-Pyne M, Dorschner M, Shirts B, Jarvik GP. Insurance coverage does not predict outcomes of genetic testing: The search for meaning in payer decisions for germline cancer tests. Journal of Genetic Counseling. PMID 31317629 DOI: 10.1002/Jgc4.1155  0.356
2019 Ranola JMO, Tsai GJ, Shirts BH. Exploring the effect of ascertainment bias on genetic studies that use clinical pedigrees. European Journal of Human Genetics : Ejhg. PMID 31296927 DOI: 10.1038/S41431-019-0467-5  0.365
2019 Tsai GJ, Garrett LT, Makhnoon S, Bowen DJ, Burke W, Shirts BH. Patient goals, motivations, and attitudes in a patient-driven variant reclassification study. Journal of Genetic Counseling. 28: 558-569. PMID 31163102 DOI: 10.1002/Jgc4.1052  0.315
2019 Makhnoon S, Shirts BH, Bowen DJ. Patients' perspectives of variants of uncertain significance and strategies for uncertainty management. Journal of Genetic Counseling. PMID 30636062 DOI: 10.1002/Jgc4.1075  0.332
2018 Tsai GJ, Rañola JMO, Smith C, Garrett LT, Bergquist T, Casadei S, Bowen DJ, Shirts BH. Outcomes of 92 patient-driven family studies for reclassification of variants of uncertain significance. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 30374176 DOI: 10.1038/S41436-018-0335-7  0.3
2018 Harrison SM, Dolinksy JS, Chen W, Collins CD, Das S, Deignan JL, Garber KB, Garcia J, Jarinova O, Knight Johnson AE, Koskenvuo JW, Lee H, Mao R, Mar-Heyming R, McFaddin AS, ... ... Shirts BH, et al. Scaling resolution of variant classification differences in ClinVar between 41 clinical laboratories through an outlier approach. Human Mutation. 39: 1641-1649. PMID 30311378 DOI: 10.1002/Humu.23643  0.336
2018 Makhnoon S, Garrett LT, Burke W, Bowen DJ, Shirts BH. Experiences of patients seeking to participate in variant of uncertain significance reclassification research. Journal of Community Genetics. PMID 30027524 DOI: 10.1007/S12687-018-0375-3  0.347
2018 Ranola JMO, Pearlman R, Hampel H, Shirts BH. Modified capture-recapture estimates of the number of families with Lynch syndrome in Central Ohio. Familial Cancer. PMID 30019097 DOI: 10.1007/S10689-018-0096-0  0.301
2018 Herman DS, Smith C, Liu C, Vaughn CP, Palaniappan S, Pritchard CC, Shirts BH. Efficient Detection of Copy Number Mutations in PMS2 Exons with Close Homologs: Detection of copy number variants in 3' PMS2 exons. The Journal of Molecular Diagnostics : Jmd. PMID 29792936 DOI: 10.1016/J.Jmoldx.2018.03.010  0.31
2018 Grasso CS, Giannakis M, Wells DK, Hamada T, Mu XJ, Quist M, Nowak JA, Nishihara R, Qian ZR, Inamura K, Morikawa T, Nosho K, Abril-Rodriguez G, Connolly C, Escuin-Ordinas H, ... ... Shirts B, et al. Genetic mechanisms of immune evasion in colorectal cancer. Cancer Discovery. PMID 29510987 DOI: 10.1158/2159-8290.Cd-17-1327  0.312
2018 Makhnoon S, Shirts BH, Bowen DJ, Fullerton SM. Hereditary cancer gene panel test reports: wide heterogeneity suggests need for standardization. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 29493582 DOI: 10.1038/Gim.2018.23  0.378
2018 Lincoln S, Zook J, Truty R, Chowdhury S, Fellowes A, Mahamdallie S, Ferber M, Cleveland M, Huang C, Tomson F, Klee E, DeSilva W, Seal S, Aradhya S, Nussbaum R, ... ... Shirts B, et al. Abstract P4-06-08: An interlaboratory study of complex mutation detection in genes associated with hereditary breast and ovarian cancer highlights both successes and current challenges Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-P4-06-08  0.359
2017 Rañola JMO, Liu Q, Rosenthal EA, Shirts BH. A comparison of cosegregation analysis methods for the clinical setting. Familial Cancer. PMID 28695303 DOI: 10.1007/S10689-017-0017-7  0.337
2017 Lieberman S, Walsh T, Schechter M, Adar T, Goldin E, Beeri R, Sharon N, Baris H, Ben Avi L, Half E, Lerer I, Shirts BH, Pritchard CC, Tomlinson I, King MC, et al. Features of Patients With Hereditary Mixed Polyposis Syndrome Caused by Duplication of GREM1 and Implications for Screening and Surveillance. Gastroenterology. PMID 28242209 DOI: 10.1053/J.Gastro.2017.02.014  0.324
2016 O'Daniel JM, McLaughlin HM, Amendola LM, Bale SJ, Berg JS, Bick D, Bowling KM, Chao EC, Chung WK, Conlin LK, Cooper GM, Das S, Deignan JL, Dorschner MO, Evans JP, ... ... Shirts BH, et al. A survey of current practices for genomic sequencing test interpretation and reporting processes in US laboratories. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 27811861 DOI: 10.1038/Gim.2016.152  0.337
2016 Shirts BH, Pritchard CC, Walsh T. Family-Specific Variants and the Limits of Human Genetics. Trends in Molecular Medicine. PMID 27742414 DOI: 10.1016/J.Molmed.2016.09.007  0.411
2016 Garrett LT, Hickman N, Jacobson A, Bennett RL, Amendola LM, Rosenthal EA, Shirts BH. Family Studies for Classification of Variants of Uncertain Classification: Current Laboratory Clinical Practice and a New Web-Based Educational Tool. Journal of Genetic Counseling. PMID 27422780 DOI: 10.1007/S10897-016-9993-2  0.37
2016 Green RC, Goddard KA, Jarvik GP, Amendola LM, Appelbaum PS, Berg JS, Bernhardt BA, Biesecker LG, Biswas S, Blout CL, Bowling KM, Brothers KB, Burke W, Caga-Anan CF, Chinnaiyan AM, ... ... Shirts B, et al. Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine. American Journal of Human Genetics. PMID 27181682 DOI: 10.1016/J.Ajhg.2016.04.011  0.343
2016 Mather CA, Mooney SD, Salipante SJ, Scroggins S, Wu D, Pritchard CC, Shirts BH. CADD score has limited clinical validity for the identification of pathogenic variants in noncoding regions in a hereditary cancer panel. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 27148939 DOI: 10.1038/Gim.2016.44  0.326
2016 Shirts BH, Casadei S, Jacobson AL, Lee MK, Gulsuner S, Bennett RL, Miller M, Hall SA, Hampel H, Hisama FM, Naylor LV, Goetsch C, Leppig K, Tait JF, Scroggins SM, et al. Improving performance of multigene panels for genomic analysis of cancer predisposition. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 26845104 DOI: 10.1038/Gim.2015.212  0.329
2016 Benson AA, Shirts BH, Jacobson A, Pritchard CC, Walsh T, Jacob H, Goldberg Y. Polyposis Caused by Low APC Mosaicism Journal of Genetic Syndromes & Gene Therapy. 7. DOI: 10.4172/2157-7412.1000281  0.318
2015 Gallego CJ, Perez ML, Burt A, Amendola LM, Shirts BH, Pritchard CC, Hisama FM, Bennett RL, Veenstra DL, Jarvik GP. Next Generation Sequencing in the Clinic: a Patterns of Care Study in a Retrospective Cohort of Subjects Referred to a Genetic Medicine Clinic for Suspected Lynch Syndrome. Journal of Genetic Counseling. PMID 26637299 DOI: 10.1007/S10897-015-9902-0  0.384
2015 Gallego CJ, Shirts BH, Bennette CS, Guzauskas G, Amendola LM, Horike-Pyne M, Hisama FM, Pritchard CC, Grady WM, Burke W, Jarvik GP, Veenstra DL. Next-Generation Sequencing Panels for the Diagnosis of Colorectal Cancer and Polyposis Syndromes: A Cost-Effectiveness Analysis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 33: 2084-91. PMID 25940718 DOI: 10.1200/Jco.2014.59.3665  0.303
2015 Amendola LM, Dorschner MO, Robertson PD, Salama JS, Hart R, Shirts BH, Murray ML, Tokita MJ, Gallego CJ, Kim DS, Bennett JT, Crosslin DR, Ranchalis J, Jones KL, Rosenthal EA, et al. Actionable exomic incidental findings in 6503 participants: challenges of variant classification. Genome Research. 25: 305-15. PMID 25637381 DOI: 10.1101/Gr.183483.114  0.363
2014 Shirts BH, Salipante SJ, Casadei S, Ryan S, Martin J, Jacobson A, Vlaskin T, Koehler K, Livingston RJ, King MC, Walsh T, Pritchard CC. Deep sequencing with intronic capture enables identification of an APC exon 10 inversion in a patient with polyposis. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 16: 783-6. PMID 24675673 DOI: 10.1038/Gim.2014.30  0.311
2014 Dorschner MO, Amendola LM, Shirts BH, Kiedrowski L, Salama J, Gordon AS, Fullerton SM, Tarczy-Hornoch P, Byers PH, Jarvik GP. Refining the structure and content of clinical genomic reports. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. 166: 85-92. PMID 24616401 DOI: 10.1002/Ajmg.C.31395  0.337
2014 Shirts BH, Jacobson A, Jarvik GP, Browning BL. Large numbers of individuals are required to classify and define risk for rare variants in known cancer risk genes. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 16: 529-34. PMID 24357849 DOI: 10.1038/Gim.2013.187  0.373
2013 Cohen DA, Shirts BH, Jackson BR, Parker LS. Laboratory informatics based evaluation of methylene tetrahydrofolate reductase C677T genetic test overutilization. Journal of Pathology Informatics. 4: 33. PMID 24392247 DOI: 10.4103/2153-3539.122389  0.327
2013 Dorschner MO, Amendola LM, Turner EH, Robertson PD, Shirts BH, Gallego CJ, Bennett RL, Jones KL, Tokita MJ, Bennett JT, Kim JH, Rosenthal EA, Kim DS, Tabor HK, et al. Actionable, pathogenic incidental findings in 1,000 participants' exomes. American Journal of Human Genetics. 93: 631-40. PMID 24055113 DOI: 10.1016/J.Ajhg.2013.08.006  0.351
2013 Shirts BH, Bennett ST, Jackson BR. Using patients like my patient for clinical decision support: institution-specific probability of celiac disease diagnosis using simplified near-neighbor classification. Journal of General Internal Medicine. 28: 1565-72. PMID 23645451 DOI: 10.1007/S11606-013-2443-Z  0.302
2012 Shirts BH, Larsen N, Jackson BR. Utilization and utility of clinical laboratory reports with graphical elements. Journal of Pathology Informatics. 3: 26. PMID 23024885 DOI: 10.4103/2153-3539.100145  0.302
2011 Melis R, Fauron C, McMillin G, Lyon E, Shirts B, Hubley LM, Slev PR. Simultaneous genotyping of rs12979860 and rs8099917 variants near the IL28B locus associated with HCV clearance and treatment response. The Journal of Molecular Diagnostics : Jmd. 13: 446-51. PMID 21704279 DOI: 10.1016/J.Jmoldx.2011.03.008  0.323
2011 Shirts BH, Hasstedt SJ, Hopkins PN, Hunt SC. Evaluation of the gene-age interactions in HDL cholesterol, LDL cholesterol, and triglyceride levels: the impact of the SORT1 polymorphism on LDL cholesterol levels is age dependent. Atherosclerosis. 217: 139-41. PMID 21466885 DOI: 10.1016/J.Atherosclerosis.2011.03.008  0.306
2011 Shirts BH, Wilson AR, Jackson BR. Partitioning reference intervals by use of genetic information. Clinical Chemistry. 57: 475-81. PMID 21164036 DOI: 10.1373/Clinchem.2010.154005  0.306
2010 Prasad KM, Bamne MN, Shirts BH, Goradia D, Mannali V, Pancholi KM, Xue B, McClain L, Yolken RH, Keshavan MS, Nimgaonkar VL. Grey matter changes associated with host genetic variation and exposure to Herpes Simplex Virus 1 (HSV1) in first episode schizophrenia. Schizophrenia Research. 118: 232-9. PMID 20138739 DOI: 10.1016/J.Schres.2010.01.007  0.556
2008 Shirts BH, Parker LS. Changing interpretations, stable genes: responsibilities of patients, professionals, and policy makers in the clinical interpretation of complex genetic information. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 10: 778-83. PMID 18941419 DOI: 10.1097/Gim.0B013E31818Bb38F  0.332
2008 Shirts BH, Prasad KM, Pogue-Geile MF, Dickerson F, Yolken RH, Nimgaonkar VL. Antibodies to cytomegalovirus and Herpes Simplex Virus 1 associated with cognitive function in schizophrenia. Schizophrenia Research. 106: 268-74. PMID 18801645 DOI: 10.1016/J.Schres.2008.07.017  0.527
2008 Shirts BH, Wood J, Yolken RH, Nimgaonkar VL. Comprehensive evaluation of positional candidates in the IL-18 pathway reveals suggestive associations with schizophrenia and herpes virus seropositivity. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 147: 343-50. PMID 18092318 DOI: 10.1002/Ajmg.B.30603  0.568
2008 Talkowski ME, Kirov G, Bamne M, Georgieva L, Torres G, Mansour H, Chowdari KV, Milanova V, Wood J, McClain L, Prasad K, Shirts B, Zhang J, O'Donovan MC, Owen MJ, et al. A network of dopaminergic gene variations implicated as risk factors for schizophrenia. Human Molecular Genetics. 17: 747-58. PMID 18045777 DOI: 10.1093/Hmg/Ddm347  0.641
2007 Shirts BH, Kim JJ, Reich S, Dickerson FB, Yolken RH, Devlin B, Nimgaonkar VL. Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk. Schizophrenia Research. 94: 342-53. PMID 17561376 DOI: 10.1016/J.Schres.2007.04.021  0.564
2007 Kim JJ, Shirts BH, Dayal M, Bacanu SA, Wood J, Xie W, Zhang X, Chowdari KV, Yolken R, Devlin B, Nimgaonkar VL. Are exposure to cytomegalovirus and genetic variation on chromosome 6p joint risk factors for schizophrenia? Annals of Medicine. 39: 145-53. PMID 17453677 DOI: 10.1080/07853890601083808  0.558
2007 Prasad KM, Shirts BH, Yolken RH, Keshavan MS, Nimgaonkar VL. Brain morphological changes associated with exposure to HSV1 in first-episode schizophrenia. Molecular Psychiatry. 12: 105-13, 1. PMID 17033628 DOI: 10.1038/Sj.Mp.4001915  0.533
2007 Prasad KMR, Shirts BH, Yolken RH, Keshavan MS, Nimgaonkar VL. HSV1 exposure affects prefrontal cortical structure in schizophrenia patients Molecular Psychiatry. 12: 1. DOI: 10.1038/Sj.Mp.4001942  0.519
2006 Shirts BH, Wood J, Yolken RH, Nimgaonkar VL. Association study of IL10, IL1beta, and IL1RN and schizophrenia using tag SNPs from a comprehensive database: suggestive association with rs16944 at IL1beta. Schizophrenia Research. 88: 235-44. PMID 16905295 DOI: 10.1016/J.Schres.2006.06.037  0.578
2006 Shirts BH, Bamne M, Kim JJ, Talkowski M, Wood J, Yolken R, Nimgaonkar VL. A comprehensive genetic association and functional study of TNF in schizophrenia risk. Schizophrenia Research. 83: 7-13. PMID 16503400 DOI: 10.1016/J.Schres.2005.12.853  0.668
2004 Shirts BH, Nimgaonkar V. The genes for schizophrenia: finally a breakthrough? Current Psychiatry Reports. 6: 303-12. PMID 15260947 DOI: 10.1007/S11920-004-0081-1  0.545
2004 Shirts BH, Nimgaonkar V. The genes for schizophrenia: Finally a breakthrough? Current Psychosis and Therapeutics Reports. 2: 57-66. DOI: 10.1007/s11922-004-0032-7  0.468
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