| Year |
Citation |
Score |
| 2022 |
Kipnis Y, Chaib AO, Vorobieva AA, Cai G, Reggiano G, Basanta B, Kumar E, Mittl PRE, Hilvert D, Baker D. Design and optimization of enzymatic activity in a de novo β-barrel scaffold. Protein Science : a Publication of the Protein Society. 31: e4405. PMID 36305767 DOI: 10.1002/pro.4405 |
0.305 |
|
| 2022 |
Lovelock SL, Crawshaw R, Basler S, Levy C, Baker D, Hilvert D, Green AP. The road to fully programmable protein catalysis. Nature. 606: 49-58. PMID 35650353 DOI: 10.1038/s41586-022-04456-z |
0.638 |
|
| 2021 |
Basler S, Studer S, Zou Y, Mori T, Ota Y, Camus A, Bunzel HA, Helgeson RC, Houk KN, Jiménez-Osés G, Hilvert D. Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold. Nature Chemistry. PMID 33526894 DOI: 10.1038/s41557-020-00628-4 |
0.311 |
|
| 2020 |
Otten R, Pádua RAP, Bunzel HA, Nguyen V, Pitsawong W, Patterson M, Sui S, Perry SL, Cohen AE, Hilvert D, Kern D. How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science (New York, N.Y.). PMID 33214289 DOI: 10.1126/science.abd3623 |
0.305 |
|
| 2020 |
Macdonald DS, Hilvert D. Enhancing promiscuous chemistries of a Schiff-base forming enzyme by divergent evolution. Methods in Enzymology. 644: 95-120. PMID 32943152 DOI: 10.1016/Bs.Mie.2020.06.014 |
0.373 |
|
| 2020 |
Tinzl M, Hilvert D. Trapping transient protein species by genetic code expansion Chembiochem. PMID 32810341 DOI: 10.1002/Cbic.202000523 |
0.412 |
|
| 2020 |
Russ WP, Figliuzzi M, Stocker C, Barrat-Charlaix P, Socolich M, Kast P, Hilvert D, Monasson R, Cocco S, Weigt M, Ranganathan R. An evolution-based model for designing chorismate mutase enzymes. Science (New York, N.Y.). 369: 440-445. PMID 32703877 DOI: 10.1126/Science.Aba3304 |
0.382 |
|
| 2020 |
Macdonald DS, Garrabou X, Klaus C, Verez R, Mori T, Hilvert D. Engineered artificial carboligases facilitate regioselective preparation of enantioenriched aldol adducts. Journal of the American Chemical Society. PMID 32427470 DOI: 10.1021/Jacs.0C02351 |
0.408 |
|
| 2019 |
Tytgat HLP, Lin CW, Levasseur MD, Tomek MB, Rutschmann C, Mock J, Liebscher N, Terasaka N, Azuma Y, Wetter M, Bachmann MF, Hilvert D, Aebi M, Keys TG. Cytoplasmic glycoengineering enables biosynthesis of nanoscale glycoprotein assemblies. Nature Communications. 10: 5403. PMID 31776333 DOI: 10.1038/S41467-019-13283-2 |
0.391 |
|
| 2019 |
Weitzner BD, Kipnis Y, Daniel AG, Hilvert D, Baker D. A computational method for design of connected catalytic networks in proteins. Protein Science : a Publication of the Protein Society. PMID 31642127 DOI: 10.1002/Pro.3757 |
0.356 |
|
| 2019 |
Sasaki E, Dragoman RM, Mantri S, Dirin DN, Kovalenko MV, Hilvert D. Self-Assembly of Proteinaceous Shells Around Positively Charged Gold Nanomaterials Enhances Colloidal Stability in High Ionic Strength Buffers. Chembiochem : a European Journal of Chemical Biology. PMID 31523885 DOI: 10.1002/Cbic.201900469 |
0.32 |
|
| 2019 |
Bunzel HA, Kries H, Marchetti L, Zeymer C, Mittl P, Mulholland AJ, Hilvert D. Emergence of a negative activation heat capacity during evolution of a designed enzyme. Journal of the American Chemical Society. PMID 31282667 DOI: 10.1021/Jacs.9B02731 |
0.378 |
|
| 2019 |
Edwardson TGW, Hilvert D. Virus-Inspired Function in Engineered Protein Cages. Journal of the American Chemical Society. 141: 9432-9443. PMID 31117660 DOI: 10.1021/Jacs.9B03705 |
0.355 |
|
| 2019 |
Sasaki E, Hilvert D. [Structure and Self-assembly of Negatively Supercharged Protein Cages]. Yakugaku Zasshi-Journal of the Pharmaceutical Society of Japan. 139: 199-208. PMID 30713229 DOI: 10.1248/Yakushi.18-00169-2 |
0.376 |
|
| 2019 |
Niquille DL, Hansen DA, Hilvert D. Reprogramming Nonribosomal Peptide Synthesis by Surgical Mutation Synlett. 30: 2123-2130. DOI: 10.1055/S-0039-1690711 |
0.305 |
|
| 2019 |
Grogg M, Hilvert D, Beck AK, Seebach D. Syntheses of Cyanophycin Segments for Investigations of Cell-Penetration Synthesis. 51: 31-39. DOI: 10.1055/S-0037-1610202 |
0.311 |
|
| 2018 |
Studer S, Hansen DA, Pianowski ZL, Mittl PRE, Debon A, Guffy SL, Der BS, Kuhlman B, Hilvert D. Evolution of a highly active and enantiospecific metalloenzyme from short peptides. Science (New York, N.Y.). 362: 1285-1288. PMID 30545884 DOI: 10.1126/Science.Aau3744 |
0.743 |
|
| 2018 |
Edwardson TGW, Mori T, Hilvert D. Rational Engineering of a Designed Protein Cage for siRNA Delivery. Journal of the American Chemical Society. 140: 10439-10442. PMID 30091604 DOI: 10.1021/Jacs.8B06442 |
0.328 |
|
| 2018 |
Azuma Y, Hilvert D. Enzyme Encapsulation in an Engineered Lumazine Synthase Protein Cage Methods of Molecular Biology. 1798: 39-55. PMID 29868950 DOI: 10.1007/978-1-4939-7893-9_4 |
0.434 |
|
| 2018 |
Hayashi T, Hilvert D, Green AP. Engineered Metalloenzymes with Non-Canonical Coordination Environments. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29786902 DOI: 10.1002/Chem.201800975 |
0.636 |
|
| 2018 |
Terasaka N, Azuma Y, Hilvert D. Laboratory evolution of virus-like nucleocapsids from nonviral protein cages. Proceedings of the National Academy of Sciences of the United States of America. 115: 5432-5437. PMID 29735682 DOI: 10.1073/Pnas.1800527115 |
0.332 |
|
| 2018 |
Azuma Y, Edwardson TGW, Hilvert D. Tailoring lumazine synthase assemblies for bionanotechnology Chemical Society Reviews. 47: 3543-3557. PMID 29714396 DOI: 10.1039/C8Cs00154E |
0.377 |
|
| 2018 |
Zeymer C, Hilvert D. Directed Evolution of Protein Catalysts. Annual Review of Biochemistry. 87: 131-157. PMID 29494241 DOI: 10.1146/Annurev-Biochem-062917-012034 |
0.437 |
|
| 2018 |
Niquille DL, Hansen DA, Mori T, Fercher D, Kries H, Hilvert D. Nonribosomal biosynthesis of backbone-modified peptides. Nature Chemistry. 10: 282-287. PMID 29461527 DOI: 10.1038/Nchem.2891 |
0.345 |
|
| 2018 |
Garrabou Pi X, Macdonald DS, Wicky BIM, Hilvert D. Stereodivergent Evolution of Artificial Enzymes for the Michael Reaction. Angewandte Chemie (International Ed. in English). PMID 29446221 DOI: 10.1002/Anie.201712554 |
0.407 |
|
| 2018 |
Bunzel HA, Garrabou X, Pott M, Hilvert D. Speeding up enzyme discovery and engineering with ultrahigh-throughput methods. Current Opinion in Structural Biology. 48: 149-156. PMID 29413955 DOI: 10.1016/J.Sbi.2017.12.010 |
0.353 |
|
| 2018 |
Pott M, Hayashi T, Mori T, Mittl PRE, Green AP, Hilvert D. A Non-Canonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold. Journal of the American Chemical Society. PMID 29309143 DOI: 10.1021/Jacs.7B12621 |
0.666 |
|
| 2018 |
Azuma Y, Edwardson TGW, Terasaka N, Hilvert D. Modular Protein Cages for Size-Selective RNA Packaging in Vivo Journal of the American Chemical Society. 140: 566-569. PMID 29278497 DOI: 10.1021/Jacs.7B10798 |
0.319 |
|
| 2018 |
Azuma Y, Bader DLV, Hilvert D. Substrate Sorting by a Supercharged Nanoreactor Journal of the American Chemical Society. 140: 860-863. PMID 29278496 DOI: 10.1021/Jacs.7B11210 |
0.414 |
|
| 2018 |
Azuma Y, Herger M, Hilvert D. Diversification of Protein Cage Structure Using Circularly Permuted Subunits Journal of the American Chemical Society. 140: 558-561. PMID 29257675 DOI: 10.1021/Jacs.7B10513 |
0.395 |
|
| 2018 |
Hayashi T, Hilvert D, Green AP. Frontispiece: Engineered Metalloenzymes with Non‐Canonical Coordination Environments Chemistry – a European Journal. 24. DOI: 10.1002/Chem.201884661 |
0.557 |
|
| 2017 |
Dragoman RM, Grogg M, Bodnarchuk MI, Tiefenboeck P, Hilvert D, Dirin DN, Kovalenko MV. Surface-Engineered Cationic Nanocrystals Stable in Biological Buffers and High Ionic Strength Solutions. Chemistry of Materials : a Publication of the American Chemical Society. 29: 9416-9428. PMID 29606797 DOI: 10.1021/Acs.Chemmater.7B03504 |
0.302 |
|
| 2017 |
Tetter S, Hilvert D. Enzyme Encapsulation by a Ferritin Cage Angewandte Chemie. 56: 14933-14936. PMID 28902449 DOI: 10.1002/Anie.201708530 |
0.409 |
|
| 2017 |
Obexer R, Pott M, Zeymer C, Griffiths AD, Hilvert D. Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting. Protein Engineering, Design & Selection : Peds. 30: 531. PMID 28873983 DOI: 10.1093/Protein/Gzx032 |
0.36 |
|
| 2017 |
Zeymer C, Zschoche R, Hilvert D. Optimization of Enzyme Mechanism along the Evolutionary Trajectory of a Computationally Designed (Retro-)Aldolase Journal of the American Chemical Society. 139: 12541-12549. PMID 28783336 DOI: 10.1021/Jacs.7B05796 |
0.385 |
|
| 2017 |
Dince CC, Meoded RA, Hilvert D. Synthesis and characterization of catalytically active thiazolium gold(I)-carbenes Chemical Communications. 53: 7585-7587. PMID 28638911 DOI: 10.1039/C7Cc03791K |
0.306 |
|
| 2017 |
Azuma Y, Zschoche R, Hilvert D. The C-terminal peptide of Aquifex aeolicus riboflavin synthase directs encapsulation of native and foreign guests by a cage-forming lumazine synthase Journal of Biological Chemistry. 292: 10321-10327. PMID 28515315 DOI: 10.1074/Jbc.C117.790311 |
0.387 |
|
| 2017 |
Sasaki E, Böhringer D, van de Waterbeemd M, Leibundgut M, Zschoche R, Heck AJ, Ban N, Hilvert D. Structure and assembly of scalable porous protein cages. Nature Communications. 8: 14663. PMID 28281548 DOI: 10.1038/Ncomms14663 |
0.359 |
|
| 2017 |
Václavík J, Zschoche R, Klimánková I, Matoušek V, Beier P, Hilvert D, Togni A. Irreversible Cysteine-Selective Protein Labeling Employing Modular Electrophilic Tetrafluoroethylation Reagents. Chemistry (Weinheim An Der Bergstrasse, Germany). 23: 6490-6494. PMID 28195376 DOI: 10.1002/Chem.201700607 |
0.399 |
|
| 2017 |
Garrabou Pi X, Macdonald DS, Hilvert D. Chemoselective Henry condensations catalyzed by artificial carboligases. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28070900 DOI: 10.1002/Chem.201605757 |
0.408 |
|
| 2017 |
Obexer R, Godina A, Garrabou X, Mittl PR, Baker D, Griffiths AD, Hilvert D. Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase. Nature Chemistry. 9: 50-56. PMID 27995916 DOI: 10.1038/Nchem.2596 |
0.456 |
|
| 2017 |
Garrabou X, Verez R, Hilvert D. Enantiocomplementary Synthesis of γ-Nitroketones Using Designed and Evolved Carboligases. Journal of the American Chemical Society. 139: 103-106. PMID 27992715 DOI: 10.1021/Jacs.6B11928 |
0.364 |
|
| 2017 |
Root K, Frey R, Hilvert D, Zenobi R. High-Mass MALDI-MS Analysis for the Investigation of Protein Encapsulation within an Engineered Capsid Forming Protein Helvetica Chimica Acta. 100. DOI: 10.1002/Hlca.201700166 |
0.338 |
|
| 2017 |
Václavík J, Zschoche R, Klimánková I, Matoušek V, Beier P, Hilvert D, Togni A. Inside Cover: Irreversible Cysteine‐Selective Protein Labeling Employing Modular Electrophilic Tetrafluoroethylation Reagents (Chem. Eur. J. 27/2017) Chemistry: a European Journal. 23: 6462-6462. DOI: 10.1002/Chem.201701036 |
0.314 |
|
| 2016 |
Obexer R, Pott M, Zeymer C, Griffiths AD, Hilvert D. Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting. Protein Engineering, Design & Selection : Peds. PMID 27542390 DOI: 10.1093/Protein/Gzw032 |
0.404 |
|
| 2016 |
Liu Z, Lebrun V, Kitanosono T, Mallin H, Köhler V, Häussinger D, Hilvert D, Kobayashi S, Ward TR. Upregulation of an Artificial Zymogen by Proteolysis. Angewandte Chemie (International Ed. in English). PMID 27529471 DOI: 10.1002/Anie.201605010 |
0.302 |
|
| 2016 |
Green AP, Hayashi T, Mittl PR, Hilvert D. A Chemically Programmed Proximal Ligand Enhances the Catalytic Properties of a Heme Enzyme. Journal of the American Chemical Society. PMID 27500802 DOI: 10.1021/Jacs.6B07029 |
0.665 |
|
| 2016 |
Frey R, Hayashi T, Hilvert D. Enzyme-mediated polymerization inside engineered protein cages. Chemical Communications. 52: 10423-10426. PMID 27484787 DOI: 10.1039/C6Cc05301G |
0.372 |
|
| 2016 |
Frey R, Mantri S, Rocca M, Hilvert D. Bottom-up Construction of a Primordial Carboxysome Mimic. Journal of the American Chemical Society. 138: 10072-10075. PMID 27479274 DOI: 10.1021/Jacs.6B04744 |
0.386 |
|
| 2016 |
MacDonald MJ, Lavis LD, Hilvert D, Gellman SH. Evaluation of the Ser-His Dipeptide, a Putative Catalyst of Amide and Ester Hydrolysis. Organic Letters. PMID 27400366 DOI: 10.1021/Acs.Orglett.6B01279 |
0.543 |
|
| 2016 |
Garrabou X, Wicky BIM, Hilvert D. Fast Knoevenagel Condensations Catalyzed by an Artificial Schiff-Base-Forming Enzyme. Journal of the American Chemical Society. 138: 6972-6974. PMID 27196438 DOI: 10.1021/Jacs.6B00816 |
0.436 |
|
| 2016 |
Heinze K, Sasaki E, King NP, Baker D, Hilvert D, Wuite GJ, Roos WH. Protein Nanocontainers from Nonviral Origin: Testing the Mechanics of Artificial and Natural Protein Cages by AFM. The Journal of Physical Chemistry. B. PMID 27187612 DOI: 10.1021/Acs.Jpcb.6B01464 |
0.312 |
|
| 2016 |
Sasaki E, Hilvert D. Self-Assembly of Proteinaceous Multishell Structures Mediated by a Supercharged Protein Journal of Physical Chemistry B. 120: 6089-6095. PMID 27064167 DOI: 10.1021/Acs.Jpcb.6B02068 |
0.361 |
|
| 2016 |
Torbeev V, Grogg M, Ruiz J, Boehringer R, Schirer A, Hellwig P, Jeschke G, Hilvert D. Chiral recognition in amyloid fiber growth. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 26929241 DOI: 10.1002/Psc.2861 |
0.688 |
|
| 2016 |
Azuma Y, Zschoche R, Tinzl M, Hilvert D. Quantitative Packaging of Active Enzymes into a Protein Cage. Angewandte Chemie (International Ed. in English). 55: 1531-4. PMID 26695342 DOI: 10.1002/Anie.201508414 |
0.443 |
|
| 2015 |
Metanis N, Hilvert D. Harnessing selenocysteine reactivity for oxidative protein folding. Chemical Science. 6: 322-325. PMID 28757941 DOI: 10.1039/C4Sc02379J |
0.705 |
|
| 2015 |
Schulz JD, Patt M, Basler S, Kries H, Hilvert D, Gauthier MA, Leroux JC. Site-Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract. Advanced Materials (Deerfield Beach, Fla.). PMID 26640034 DOI: 10.1002/Adma.201504797 |
0.301 |
|
| 2015 |
Zschoche R, Hilvert D. Diffusion-Limited Cargo Loading of an Engineered Protein Container. Journal of the American Chemical Society. 137: 16121-32. PMID 26637019 DOI: 10.1021/Jacs.5B10588 |
0.333 |
|
| 2015 |
Vandemeulebroucke A, Aldag C, Stiebritz MT, Reiher M, Hilvert D. Kinetic consequences of introducing a proximal selenocysteine ligand into cytochrome P450cam. Biochemistry. 54: 6692-703. PMID 26460790 DOI: 10.1021/Acs.Biochem.5B00939 |
0.33 |
|
| 2015 |
Kries H, Niquille DL, Hilvert D. A Subdomain Swap Strategy for Reengineering Nonribosomal Peptides Chemistry & Biology. 22: 640-648. PMID 26000750 DOI: 10.1016/J.Chembiol.2015.04.015 |
0.373 |
|
| 2015 |
Garrabou X, Beck T, Hilvert D. A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates. Angewandte Chemie (International Ed. in English). 54: 5609-12. PMID 25777153 DOI: 10.1002/Anie.201500217 |
0.38 |
|
| 2015 |
Schulenburg C, Stark Y, Künzle M, Hilvert D. Comparative laboratory evolution of ordered and disordered enzymes. Journal of Biological Chemistry. 290: 9310-9320. PMID 25697360 DOI: 10.1074/Jbc.M115.638080 |
0.397 |
|
| 2015 |
Torbeev V, Ebert MO, Dolenc J, Hilvert D. Substitution of proline32 by α-methylproline preorganizes β2-microglobulin for oligomerization but not for aggregation into amyloids. Journal of the American Chemical Society. 137: 2524-35. PMID 25633201 DOI: 10.1021/Ja510109P |
0.715 |
|
| 2015 |
Beck T, Tetter S, Künzle M, Hilvert D. Construction of Matryoshka-type structures from supercharged protein nanocages. Angewandte Chemie (International Ed. in English). 54: 937-40. PMID 25392947 DOI: 10.1002/Anie.201408677 |
0.365 |
|
| 2014 |
Burschowsky D, Eerde Av, Ökvist M, Kienhöfer A, Kast P, Hilvert D, Krengel U. Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis. Proceedings of the National Academy of Sciences of the United States of America. 111: 17516-17521. PMID 25422475 DOI: 10.1073/Pnas.1408512111 |
0.374 |
|
| 2014 |
Metanis N, Hilvert D. Natural and synthetic selenoproteins. Current Opinion in Chemical Biology. 22: 27-34. PMID 25261915 DOI: 10.1016/J.Cbpa.2014.09.010 |
0.711 |
|
| 2014 |
Kries H, Wachtel R, Pabst A, Wanner B, Niquille D, Hilvert D. Reprogramming nonribosomal peptide synthetases for "clickable" amino acids. Angewandte Chemie (International Ed. in English). 53: 10105-8. PMID 25081643 DOI: 10.1002/Anie.201405281 |
0.36 |
|
| 2014 |
Preiswerk N, Beck T, Schulz JD, Milovník P, Mayer C, Siegel JB, Baker D, Hilvert D. Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase. Proceedings of the National Academy of Sciences of the United States of America. 111: 8013-8. PMID 24847076 DOI: 10.1073/Pnas.1401073111 |
0.404 |
|
| 2014 |
Mayer C, Müller MM, Gellman SH, Hilvert D. Building proficient enzymes with foldamer prostheses. Angewandte Chemie (International Ed. in English). 53: 6978-81. PMID 24828837 DOI: 10.1002/Anie.201400945 |
0.575 |
|
| 2014 |
Bjelic S, Kipnis Y, Wang L, Pianowski Z, Vorobiev S, Su M, Seetharaman J, Xiao R, Kornhaber G, Hunt JF, Tong L, Hilvert D, Baker D. Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design. Journal of Molecular Biology. 426: 256-71. PMID 24161950 DOI: 10.1016/J.Jmb.2013.10.012 |
0.736 |
|
| 2014 |
Butz M, Kast P, Hilvert D. Affinity maturation of a computationally designed binding protein affords a functional but disordered polypeptide. Journal of Structural Biology. 185: 168-177. PMID 23537847 DOI: 10.1016/J.Jsb.2013.03.008 |
0.403 |
|
| 2014 |
Obexer R, Studer S, Giger L, Pinkas DM, Grütter MG, Baker D, Hilvert D. Active site plasticity of a computationally designed retro-aldolase enzyme Chemcatchem. 6: 1043-1050. DOI: 10.1002/Cctc.201300933 |
0.409 |
|
| 2013 |
Torbeev VY, Hilvert D. Both the cis-trans equilibrium and isomerization dynamics of a single proline amide modulate β2-microglobulin amyloid assembly. Proceedings of the National Academy of Sciences of the United States of America. 110: 20051-6. PMID 24262149 DOI: 10.1073/Pnas.1310414110 |
0.7 |
|
| 2013 |
Blomberg R, Kries H, Pinkas DM, Mittl PR, Grütter MG, Privett HK, Mayo SL, Hilvert D. Precision is essential for efficient catalysis in an evolved Kemp eliminase. Nature. 503: 418-21. PMID 24132235 DOI: 10.1038/Nature12623 |
0.426 |
|
| 2013 |
Giger L, Caner S, Obexer R, Kast P, Baker D, Ban N, Hilvert D. Evolution of a designed retro-aldolase leads to complete active site remodeling Nature Chemical Biology. 9: 494-498. PMID 23748672 DOI: 10.1038/Nchembio.1276 |
0.461 |
|
| 2013 |
Hilvert D. Design of Protein Catalysts Annual Review of Biochemistry. 82: 447-470. PMID 23746259 DOI: 10.1146/Annurev-Biochem-072611-101825 |
0.42 |
|
| 2013 |
Schulenburg C, Hilvert D. Protein conformational disorder and enzyme catalysis. Topics in Current Chemistry. 337: 41-67. PMID 23536241 DOI: 10.1007/128_2012_411 |
0.398 |
|
| 2013 |
Kries H, Blomberg R, Hilvert D. De novo enzymes by computational design. Current Opinion in Chemical Biology. 17: 221-228. PMID 23498973 DOI: 10.1016/J.Cbpa.2013.02.012 |
0.39 |
|
| 2013 |
Müller MM, Allison JR, Hongdilokkul N, Gaillon L, Kast P, van Gunsteren WF, Marlière P, Hilvert D. Directed evolution of a model primordial enzyme provides insights into the development of the genetic code. Plos Genetics. 9: e1003187. PMID 23300488 DOI: 10.1371/Journal.Pgen.1003187 |
0.423 |
|
| 2013 |
Mayer C, Hilvert D. A Genetically Encodable Ligand for Transfer Hydrogenation European Journal of Organic Chemistry. 2013: 3427-3431. DOI: 10.1002/Ejoc.201300340 |
0.301 |
|
| 2012 |
Richter F, Blomberg R, Khare SD, Kiss G, Kuzin AP, Smith AJ, Gallaher J, Pianowski Z, Helgeson RC, Grjasnow A, Xiao R, Seetharaman J, Su M, Vorobiev S, Lew S, ... ... Hilvert D, et al. Computational design of catalytic dyads and oxyanion holes for ester hydrolysis. Journal of the American Chemical Society. 134: 16197-206. PMID 22871159 DOI: 10.1021/Ja3037367 |
0.75 |
|
| 2012 |
Metanis N, Hilvert D. Strategic use of non-native diselenide bridges to steer oxidative protein folding. Angewandte Chemie (International Ed. in English). 51: 5585-8. PMID 22454335 DOI: 10.1002/Anie.201109129 |
0.691 |
|
| 2012 |
Althoff EA, Wang L, Jiang L, Giger L, Lassila JK, Wang Z, Smith M, Hari S, Kast P, Herschlag D, Hilvert D, Baker D. Robust design and optimization of retroaldol enzymes. Protein Science : a Publication of the Protein Society. 21: 717-26. PMID 22407837 DOI: 10.1002/Pro.2059 |
0.398 |
|
| 2012 |
Privett HK, Kiss G, Lee TM, Blomberg R, Chica RA, Thomas LM, Hilvert D, Houk KN, Mayo SL. Iterative approach to computational enzyme design. Proceedings of the National Academy of Sciences of the United States of America. 109: 3790-5. PMID 22357762 DOI: 10.1073/Pnas.1118082108 |
0.423 |
|
| 2012 |
Wörsdörfer B, Pianowski Z, Hilvert D. Efficient in vitro encapsulation of protein cargo by an engineered protein container. Journal of the American Chemical Society. 134: 909-11. PMID 22214519 DOI: 10.1021/Ja211011K |
0.735 |
|
| 2012 |
Wang L, Althoff EA, Bolduc J, Jiang L, Moody J, Lassila JK, Giger L, Hilvert D, Stoddard B, Baker D. Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. Journal of Molecular Biology. 415: 615-25. PMID 22075445 DOI: 10.1016/J.Jmb.2011.10.043 |
0.419 |
|
| 2012 |
Burschowsky D, Eerde Av, Ökvist M, Kienhöfer A, Kast P, Hilvert D, Krengel U. Reaction mechanism of chorismate mutase, a model enzyme for pericyclic reactions, finally resolved Acta Crystallographica Section A. 68: 37-37. DOI: 10.1107/S0108767312099291 |
0.305 |
|
| 2012 |
Wörsdörfer B, Henning LM, Obexer R, Hilvert D. Harnessing protein symmetry for enzyme design Acs Catalysis. 2: 982-985. DOI: 10.1021/Cs300076T |
0.434 |
|
| 2012 |
Giger L, Toscano MD, Bouzon M, Marlière P, Hilvert D. A novel genetic selection system for PLP-dependent threonine aldolases Tetrahedron. 68: 7549-7557. DOI: 10.1016/J.Tet.2012.05.097 |
0.423 |
|
| 2012 |
Stouffer A, Bengtsson LH, Sheremet M, Hilvert D. The Interplay of Catalytic Activity and Substrate Promiscuity for an Intrinsically Disordered Staphylococcal Nuclease Biophysical Journal. 102: 634a. DOI: 10.1016/J.Bpj.2011.11.3452 |
0.389 |
|
| 2012 |
Torbeev VY, Fumi E, Ebert MO, Schweizer WB, Hilvert D. Cis-trans peptide-bond isomerization in α-methylproline derivatives Helvetica Chimica Acta. 95: 2411-2420. DOI: 10.1002/Hlca.201200483 |
0.67 |
|
| 2011 |
Kries H, Hilvert D. Tailor-Made Peptide Synthetases Chemistry & Biology. 18: 1206-1207. PMID 22035787 DOI: 10.1016/J.Chembiol.2011.10.006 |
0.331 |
|
| 2011 |
Mayer C, Gillingham DG, Ward TR, Hilvert D. An artificial metalloenzyme for olefin metathesis Chemical Communications. 47: 12068-12070. PMID 21991583 DOI: 10.1039/C1Cc15005G |
0.345 |
|
| 2011 |
Butz M, Neuenschwander M, Kast P, Hilvert D. An N-terminal protein degradation tag enables robust selection of highly active enzymes. Biochemistry. 50: 8594-602. PMID 21916414 DOI: 10.1021/Bi2011338 |
0.416 |
|
| 2011 |
Wörsdörfer B, Woycechowsky KJ, Hilvert D. Directed evolution of a protein container. Science (New York, N.Y.). 331: 589-92. PMID 21292977 DOI: 10.1126/Science.1199081 |
0.753 |
|
| 2011 |
Metanis N, Foletti C, Beld J, Hilvert D. Selenoglutathione-mediated rescue of kinetically trapped intermediates in oxidative protein folding Israel Journal of Chemistry. 51: 953-959. DOI: 10.1002/Ijch.201100105 |
0.795 |
|
| 2011 |
Metanis N, Beld J, Hilvert D. The Chemistry of Selenocysteine Patai's Chemistry of Functional Groups. DOI: 10.1002/9780470682531.Pat0582 |
0.797 |
|
| 2010 |
Gillingham DG, Stallforth P, Adibekian A, Seeberger PH, Hilvert D. Chemoenzymatic synthesis of differentially protected 3-deoxysugars. Nature Chemistry. 2: 102-5. PMID 21124399 DOI: 10.1038/Nchem.504 |
0.356 |
|
| 2010 |
Beld J, Woycechowsky KJ, Hilvert D. Diselenides as universal oxidative folding catalysts of diverse proteins. Journal of Biotechnology. 150: 481-9. PMID 20933552 DOI: 10.1016/J.Jbiotec.2010.09.956 |
0.808 |
|
| 2010 |
Jäckel C, Hilvert D. Biocatalysts by evolution. Current Opinion in Biotechnology. 21: 753-9. PMID 20850962 DOI: 10.1016/J.Copbio.2010.08.008 |
0.371 |
|
| 2010 |
Siegel JB, Zanghellini A, Lovick HM, Kiss G, Lambert AR, St Clair JL, Gallaher JL, Hilvert D, Gelb MH, Stoddard BL, Houk KN, Michael FE, Baker D. Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction. Science (New York, N.Y.). 329: 309-13. PMID 20647463 DOI: 10.1126/Science.1190239 |
0.381 |
|
| 2010 |
Jäckel C, Bloom JD, Kast P, Arnold FH, Hilvert D. Consensus protein design without phylogenetic bias. Journal of Molecular Biology. 399: 541-6. PMID 20433850 DOI: 10.1016/J.Jmb.2010.04.039 |
0.39 |
|
| 2010 |
Müller MM, Kries H, Csuhai E, Kast P, Hilvert D. Design, selection, and characterization of a split chorismate mutase. Protein Science : a Publication of the Protein Society. 19: 1000-10. PMID 20306491 DOI: 10.1002/Pro.377 |
0.414 |
|
| 2010 |
Beld J, Woycechowsky KJ, Hilvert D. Small-molecule diselenides catalyze oxidative protein folding in vivo. Acs Chemical Biology. 5: 177-82. PMID 20052969 DOI: 10.1021/Cb9002688 |
0.8 |
|
| 2010 |
Van Vleet J, Kleeb A, Kast P, Hilvert D, Cleland WW. 13C isotope effect on the reaction catalyzed by prephenate dehydratase. Biochimica Et Biophysica Acta. 1804: 752-4. PMID 19948253 DOI: 10.1016/J.Bbapap.2009.11.018 |
0.383 |
|
| 2009 |
Debler EW, Müller R, Hilvert D, Wilson IA. An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket. Proceedings of the National Academy of Sciences of the United States of America. 106: 18539-44. PMID 19846764 DOI: 10.1073/Pnas.0902700106 |
0.376 |
|
| 2009 |
Aldag C, Gromov IA, García-Rubio I, von Koenig K, Schlichting I, Jaun B, Hilvert D. Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine. Proceedings of the National Academy of Sciences of the United States of America. 106: 5481-6. PMID 19293375 DOI: 10.1073/Pnas.0810503106 |
0.654 |
|
| 2009 |
Stafforst T, Hilvert D. Kinetic characterization of spiropyrans in aqueous media. Chemical Communications. 287-288. PMID 19209304 DOI: 10.1039/B818050D |
0.332 |
|
| 2009 |
Müller MM, Windsor MA, Pomerantz WC, Gellman SH, Hilvert D. A rationally designed aldolase foldamer. Angewandte Chemie (International Ed. in English). 48: 922-5. PMID 19090515 DOI: 10.1002/Anie.200804996 |
0.582 |
|
| 2008 |
Woycechowsky KJ, Choutko A, Vamvaca K, Hilvert D. Relative tolerance of an enzymatic molten globule and its thermostable counterpart to point mutation. Biochemistry. 47: 13489-96. PMID 19053245 DOI: 10.1021/Bi801108A |
0.75 |
|
| 2008 |
Smith AJ, Müller R, Toscano MD, Kast P, Hellinga HW, Hilvert D, Houk KN. Structural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle. Journal of the American Chemical Society. 130: 15361-73. PMID 18939839 DOI: 10.1021/Ja803213P |
0.409 |
|
| 2008 |
Roca M, Messer B, Hilvert D, Warshel A. On the relationship between folding and chemical landscapes in enzyme catalysis. Proceedings of the National Academy of Sciences of the United States of America. 105: 13877-82. PMID 18779576 DOI: 10.1073/Pnas.0803405105 |
0.415 |
|
| 2008 |
Fesko K, Giger L, Hilvert D. Synthesis of β-hydroxy-α-amino acids with a reengineered alanine racemase Bioorganic & Medicinal Chemistry Letters. 18: 5987-5990. PMID 18760921 DOI: 10.1016/J.Bmcl.2008.08.031 |
0.323 |
|
| 2008 |
Verdino P, Aldag C, Hilvert D, Wilson IA. Closely related antibody receptors exploit fundamentally different strategies for steroid recognition Proceedings of the National Academy of Sciences of the United States of America. 105: 11725-11730. PMID 18689687 DOI: 10.1073/Pnas.0801783105 |
0.311 |
|
| 2008 |
Vamvaca K, Jelesarov I, Hilvert D. Kinetics and thermodynamics of ligand binding to a molten globular enzyme and its native counterpart. Journal of Molecular Biology. 382: 971-977. PMID 18680748 DOI: 10.1016/J.Jmb.2008.07.049 |
0.367 |
|
| 2008 |
Jäckel C, Kast P, Hilvert D. Protein design by directed evolution. Annual Review of Biophysics. 37: 153-73. PMID 18573077 DOI: 10.1146/Annurev.Biophys.37.032807.125832 |
0.371 |
|
| 2008 |
Beld J, Woycechowsky KJ, Hilvert D. Catalysis of oxidative protein folding by small-molecule diselenides. Biochemistry. 47: 6985-7. PMID 18553979 DOI: 10.1021/Bi8008906 |
0.796 |
|
| 2008 |
Casi G, Roelfes G, Hilvert D. Selenoglutaredoxin as a glutathione peroxidase mimic. Chembiochem : a European Journal of Chemical Biology. 9: 1623-31. PMID 18548475 DOI: 10.1002/Cbic.200700745 |
0.452 |
|
| 2008 |
Serafimov JM, Gillingham D, Kuster S, Hilvert D. The putative Diels-Alderase macrophomate synthase is an efficient aldolase. Journal of the American Chemical Society. 130: 7798-9. PMID 18512926 DOI: 10.1021/Ja8017994 |
0.33 |
|
| 2008 |
Debler EW, Müller R, Hilvert D, Wilson IA. Conformational isomerism can limit antibody catalysis. The Journal of Biological Chemistry. 283: 16554-60. PMID 18417480 DOI: 10.1074/Jbc.M710256200 |
0.411 |
|
| 2008 |
Jiang L, Althoff EA, Clemente FR, Doyle L, Röthlisberger D, Zanghellini A, Gallaher JL, Betker JL, Tanaka F, Barbas CF, Hilvert D, Houk KN, Stoddard BL, Baker D. De novo computational design of retro-aldol enzymes. Science (New York, N.Y.). 319: 1387-91. PMID 18323453 DOI: 10.1126/Science.1152692 |
0.401 |
|
| 2008 |
Piatesi A, Aldag C, Hilvert D. Switching antibody specificity through minimal mutation. Journal of Molecular Biology. 377: 993-1001. PMID 18295792 DOI: 10.1016/J.Jmb.2008.01.069 |
0.307 |
|
| 2007 |
Pervushin K, Vamvaca K, Vögeli B, Hilvert D. Structure and dynamics of a molten globular enzyme. Nature Structural & Molecular Biology. 14: 1202-1206. PMID 17994104 DOI: 10.1038/Nsmb1325 |
0.431 |
|
| 2007 |
Neuenschwander M, Butz M, Heintz C, Kast P, Hilvert D. A simple selection strategy for evolving highly efficient enzymes. Nature Biotechnology. 25: 1145-7. PMID 17873865 DOI: 10.1038/Nbt1341 |
0.377 |
|
| 2007 |
Casi G, Hilvert D. Reinvestigation of a selenopeptide with purportedly high glutathione peroxidase activity. Journal of Biological Chemistry. 282: 30518-30522. PMID 17724019 DOI: 10.1074/Jbc.M705528200 |
0.384 |
|
| 2007 |
Kleeb AC, Edalat MH, Gamper M, Haugstetter J, Giger L, Neuenschwander M, Kast P, Hilvert D. Metabolic engineering of a genetic selection system with tunable stringency. Proceedings of the National Academy of Sciences of the United States of America. 104: 13907-12. PMID 17715291 DOI: 10.1073/Pnas.0705379104 |
0.369 |
|
| 2007 |
Serafimov JM, Westfeld T, Meier BH, Hilvert D. Trapping and structural elucidation of an intermediate in the macrophomate synthase reaction pathway. Journal of the American Chemical Society. 129: 9580-1. PMID 17636922 DOI: 10.1021/Ja073087Y |
0.34 |
|
| 2007 |
Serafimov JM, Lehmann HC, Oikawa H, Hilvert D. Active site mutagenesis of the putative Diels-Alderase macrophomate synthase. Chemical Communications (Cambridge, England). 1701-3. PMID 17457413 DOI: 10.1039/B703177G |
0.324 |
|
| 2007 |
Toscano MD, Woycechowsky KJ, Hilvert D. Minimalist active-site redesign: teaching old enzymes new tricks. Angewandte Chemie (International Ed. in English). 46: 3212-36. PMID 17450624 DOI: 10.1002/Anie.200604205 |
0.751 |
|
| 2007 |
Beld J, Woycechowsky KJ, Hilvert D. Selenoglutathione: efficient oxidative protein folding by a diselenide. Biochemistry. 46: 5382-90. PMID 17419591 DOI: 10.1021/Bi700124P |
0.79 |
|
| 2007 |
Aemissegger A, Hilvert D. Synthesis and application of an azobenzene amino acid as a light-switchable turn element in polypeptides. Nature Protocols. 2: 161-167. PMID 17401350 DOI: 10.1038/Nprot.2006.488 |
0.305 |
|
| 2007 |
Müller R, Debler EW, Steinmann M, Seebeck FP, Wilson IA, Hilvert D. Bifunctional catalysis of proton transfer at an antibody active site. Journal of the American Chemical Society. 129: 460-1. PMID 17226987 DOI: 10.1021/Ja066578B |
0.312 |
|
| 2007 |
Woycechowsky KJ, Vamvaca K, Hilvert D. Novel enzymes through design and evolution. Advances in Enzymology and Related Areas of Molecular Biology. 75: 241-94, xiii. PMID 17124869 DOI: 10.1002/9780471224464.Ch4 |
0.751 |
|
| 2007 |
Toscano M, Woycechowsky K, Hilvert D. Minimale Umgestaltung aktiver Enzymtaschen – wie man alten Enzymen neue Kunststücke beibringt Angewandte Chemie. 119: 3274-3300. DOI: 10.1002/Ange.200604205 |
0.695 |
|
| 2006 |
Kleeb AC, Kast P, Hilvert D. A monofunctional and thermostable prephenate dehydratase from the archaeon Methanocaldococcus jannaschii. Biochemistry. 45: 14101-14110. PMID 17115705 DOI: 10.1021/Bi061274N |
0.392 |
|
| 2006 |
Besenmatter W, Kast P, Hilvert D. Relative tolerance of mesostable and thermostable protein homologs to extensive mutation Proteins. 66: 500-506. PMID 17096428 DOI: 10.1002/Prot.21227 |
0.431 |
|
| 2006 |
Kikuchi K, Hannak RB, Guo MJ, Kirby AJ, Hilvert D. Toward bifunctional antibody catalysis. Bioorganic & Medicinal Chemistry. 14: 6189-96. PMID 16782349 DOI: 10.1016/J.Bmc.2006.05.071 |
0.372 |
|
| 2006 |
Woycechowsky KJ, Seebeck FP, Hilvert D. Tunnel plasticity and quaternary structural integrity of a pentameric protein ring. Protein Science : a Publication of the Protein Society. 15: 1106-14. PMID 16641488 DOI: 10.1110/Ps.052044606 |
0.74 |
|
| 2006 |
Seebeck FP, Woycechowsky KJ, Zhuang W, Rabe JP, Hilvert D. A simple tagging system for protein encapsulation. Journal of the American Chemical Society. 128: 4516-7. PMID 16594656 DOI: 10.1021/Ja058363S |
0.737 |
|
| 2006 |
Verdino P, Aldag C, Hilvert D, Wilson IA. Antibodies: specificity and promiscuity of ligand recognition Acta Crystallographica Section a Foundations of Crystallography. 62: s38-s38. DOI: 10.1107/S0108767306099247 |
0.345 |
|
| 2005 |
DeClue MS, Baldridge KK, Künzler DE, Kast P, Hilvert D. Isochorismate pyruvate lyase: a pericyclic reaction mechanism? Journal of the American Chemical Society. 127: 15002-3. PMID 16248620 DOI: 10.1021/Ja055871T |
0.302 |
|
| 2005 |
Walter KU, Vamvaca K, Hilvert D. An active enzyme constructed from a 9-amino acid alphabet. The Journal of Biological Chemistry. 280: 37742-6. PMID 16144843 DOI: 10.1074/Jbc.M507210200 |
0.414 |
|
| 2005 |
Künzler DE, Sasso S, Gamper M, Hilvert D, Kast P. Mechanistic insights into the isochorismate pyruvate lyase activity of the catalytically promiscuous PchB from combinatorial mutagenesis and selection. The Journal of Biological Chemistry. 280: 32827-34. PMID 16036918 DOI: 10.1074/Jbc.M506883200 |
0.401 |
|
| 2005 |
Vamvaca K, Butz M, Walter KU, Taylor SV, Hilvert D. Simultaneous optimization of enzyme activity and quaternary structure by directed evolution. Protein Science : a Publication of the Protein Society. 14: 2103-14. PMID 15987889 DOI: 10.1110/Ps.051431605 |
0.426 |
|
| 2005 |
Eletsky A, Kienhöfer A, Hilvert D, Pervushin K. Investigation of ligand binding and protein dynamics in Bacillus subtilis chorismate mutase by transverse relaxation optimized spectroscopy-nuclear magnetic resonance. Biochemistry. 44: 6788-6799. PMID 15865424 DOI: 10.1021/Bi0474259 |
0.353 |
|
| 2005 |
Debler EW, Ito S, Seebeck FP, Heine A, Hilvert D, Wilson IA. Structural origins of efficient proton abstraction from carbon by a catalytic antibody. Proceedings of the National Academy of Sciences of the United States of America. 102: 4984-9. PMID 15788533 DOI: 10.1073/Pnas.0409207102 |
0.415 |
|
| 2005 |
Seebeck FP, Hilvert D. Positional ordering of reacting groups contributes significantly to the efficiency of proton transfer at an antibody active site. Journal of the American Chemical Society. 127: 1307-1312. PMID 15669871 DOI: 10.1021/Ja044647L |
0.365 |
|
| 2004 |
Vamvaca K, Vögeli B, Kast P, Pervushin K, Hilvert D. An enzymatic molten globule: efficient coupling of folding and catalysis. Proceedings of the National Academy of Sciences of the United States of America. 101: 12860-12864. PMID 15322276 DOI: 10.1073/Pnas.0404109101 |
0.43 |
|
| 2004 |
Besenmatter W, Kast P, Hilvert D. New enzymes from combinatorial library modules. Methods in Enzymology. 388: 91-102. PMID 15289064 DOI: 10.1016/S0076-6879(04)88009-1 |
0.38 |
|
| 2004 |
Hu Y, Houk KN, Kikuchi K, Hotta K, Hilvert D. Nonspecific medium effects versus specific group positioning in the antibody and albumin catalysis of the base-promoted ring-opening reactions of benzisoxazoles. Journal of the American Chemical Society. 126: 8197-205. PMID 15225061 DOI: 10.1021/Ja0490727 |
0.59 |
|
| 2004 |
Piatesi A, Hilvert D. Immunological optimization of a generic hydrophobic pocket for high affinity hapten binding and Diels-Alder activity. Chembiochem. 5: 460-466. PMID 15185369 DOI: 10.1002/Cbic.200300806 |
0.373 |
|
| 2004 |
Woycechowsky KJ, Hilvert D. Deciphering enzymes. Genetic selection as a probe of structure and mechanism. European Journal of Biochemistry / Febs. 271: 1630-7. PMID 15096202 DOI: 10.1111/J.1432-1033.2004.04073.X |
0.739 |
|
| 2004 |
Roelfes G, Hilvert D. Incorporation of selenomethionine into proteins through selenohomocysteine-mediated ligation. Angewandte Chemie (International Ed. in English). 42: 2275-7. PMID 12772161 DOI: 10.1002/Anie.200250830 |
0.331 |
|
| 2003 |
Wendt S, McCombie G, Daniel J, Kienhöfer A, Hilvert D, Zenobi R. Quantitative evaluation of noncovalent chorismate mutase-inhibitor binding by ESI-MS. Journal of the American Society For Mass Spectrometry. 14: 1470-1476. PMID 14652193 DOI: 10.1016/J.Jasms.2003.08.003 |
0.333 |
|
| 2003 |
Casi G, Hilvert D. Convergent protein synthesis. Current Opinion in Structural Biology. 13: 589-594. PMID 14568613 DOI: 10.1016/J.Sbi.2003.09.008 |
0.381 |
|
| 2003 |
Seebeck FP, Hilvert D. Conversion of a PLP-dependent racemase into an aldolase by a single active site mutation. Journal of the American Chemical Society. 125: 10158-10159. PMID 12926923 DOI: 10.1021/Ja036707D |
0.398 |
|
| 2003 |
Mandal A, Hilvert D. Charge Optimization Increases the Potency and Selectivity of a Chorismate Mutase Inhibitor Journal of the American Chemical Society. 125: 5598-5599. PMID 12733875 DOI: 10.1021/Ja029447T |
0.336 |
|
| 2003 |
Kienhöfer A, Kast P, Hilvert D. Selective stabilization of the chorismate mutase transition state by a positively charged hydrogen bond donor. Journal of the American Chemical Society. 125: 3206-3207. PMID 12630863 DOI: 10.1021/Ja0341992 |
0.368 |
|
| 2003 |
Ujaque G, Tantillo DJ, Hu Y, Houk KN, Hotta K, Hilvert D. Catalysis on the coastline: theozyme, molecular dynamics, and free energy perturbation analysis of antibody 21D8 catalysis of the decarboxylation of 5-nitro-3-carboxybenzisoxazole. Journal of Computational Chemistry. 24: 98-110. PMID 12483679 DOI: 10.1002/Jcc.10151 |
0.601 |
|
| 2003 |
Backes AC, Hotta K, Hilvert D. Promiscuity in Antibody Catalysis: Esterolytic Activity of the Decarboxylase 21D8 Helvetica Chimica Acta. 86: 1167-1174. DOI: 10.1002/Hlca.200390101 |
0.589 |
|
| 2002 |
Quaderer R, Hilvert D. Selenocysteine-mediated backbone cyclization of unprotected peptides followed by alkylation, oxidative elimination or reduction of the selenol. Chemical Communications. 2620-2621. PMID 12510266 DOI: 10.1039/B208288H |
0.318 |
|
| 2002 |
Eletsky A, Heinz T, Moreira O, Kienhöfer A, Hilvert D, Pervushin K. Direct NMR observation and DFT calculations of a hydrogen bond at the active site of a 44 kDa enzyme. Journal of Biomolecular Nmr. 24: 31-39. PMID 12449416 DOI: 10.1023/A:1020697627485 |
0.324 |
|
| 2002 |
Aemissegger A, Jaun B, Hilvert D. Investigation of the enzymatic and nonenzymatic cope rearrangement of carbaprephenate to carbachorismate. Journal of Organic Chemistry. 67: 6725-6730. PMID 12227803 DOI: 10.1021/Jo026096S |
0.613 |
|
| 2002 |
Chen J, Deng Q, Wang R, Houk K, Hilvert D. Shape complementarity, binding-site dynamics, and transition state stabilization: a theoretical study of Diels-Alder catalysis by antibody 1E9. Chembiochem : a European Journal of Chemical Biology. 1: 255-61. PMID 11828417 DOI: 10.1002/1439-7633(20001117)1:4<255::Aid-Cbic255>3.0.Co;2-S |
0.32 |
|
| 2002 |
Hotta K, Wilson IA, Hilvert D. Probing ligand recognition in the decarboxylase antibody 21D8: implications for the catalytic mechanism. Biochemistry. 41: 772-9. PMID 11790098 DOI: 10.1021/Bi0158167 |
0.596 |
|
| 2002 |
Piatesi A, Hilvert D. Optimized production of the Diels-Alderase antibody 1E9 as a chimeric Fab Canadian Journal of Chemistry. 80: 657-664. DOI: 10.1139/V02-057 |
0.326 |
|
| 2002 |
Gozin Y, Hilvert D. Steric and Electronic Effects on an Antibody‐Catalyzed Diels–Alder Reaction Helvetica Chimica Acta. 85: 4328-4336. DOI: 10.1002/Hlca.200290015 |
0.342 |
|
| 2001 |
Taylor SV, Kast P, Hilvert D. Investigating and Engineering Enzymes by Genetic Selection. Angewandte Chemie. 40: 3310-3335. PMID 11592132 DOI: 10.1002/1521-3773(20010917)40:18<3310::Aid-Anie3310>3.0.Co;2-P |
0.447 |
|
| 2001 |
Taylor SV, Walter KU, Kast P, Hilvert D. Searching sequence space for protein catalysts. Proceedings of the National Academy of Sciences of the United States of America. 98: 10596-601. PMID 11535813 DOI: 10.1073/Pnas.191159298 |
0.457 |
|
| 2000 |
Hotta K, Lange H, Tantillo DJ, Houk KN, Hilvert D, Wilson IA. Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8. Journal of Molecular Biology. 302: 1213-25. PMID 11183784 DOI: 10.1006/Jmbi.2000.4503 |
0.593 |
|
| 2000 |
Hilvert D. Critical Analysis of Antibody Catalysis Annual Review of Biochemistry. 69: 751-793. PMID 10966475 DOI: 10.1146/Annurev.Biochem.69.1.751 |
0.377 |
|
| 2000 |
Kast P, Grisostomi C, Chen IA, Li S, Krengel U, Xue Y, Hilvert D. A strategically positioned cation is crucial for efficient catalysis by chorismate mutase. The Journal of Biological Chemistry. 275: 36832-8. PMID 10960481 DOI: 10.1074/Jbc.M006351200 |
0.384 |
|
| 2000 |
Voordijk S, Hansson T, Hilvert D, van Gunsteren WF. Molecular dynamics simulations highlight mobile regions in proteins: A novel suggestion for converting a murine V(H) domain into a more tractable species. Journal of Molecular Biology. 300: 963-73. PMID 10891281 DOI: 10.1006/Jmbi.2000.3890 |
0.347 |
|
| 2000 |
Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA. Evolution of shape complementarity and catalytic efficiency from a primordial antibody template. Science (New York, N.Y.). 286: 2345-8. PMID 10600746 DOI: 10.1126/Science.286.5448.2345 |
0.339 |
|
| 2000 |
Hollfelder F, Kirby AJ, Tawfik DS, Kikuchi K, Hilvert D. Characterization of proton-transfer catalysis by serum albumins Journal of the American Chemical Society. 122: 1022-1029. DOI: 10.1021/Ja993471Y |
0.387 |
|
| 2000 |
Hotta K, Kikuchi K, Hilvert D. Catalysis of 3‐Carboxy‐1,2‐benzisoxazole Decarboxylation by Hydrophobic Antibody Binding Pockets Helvetica Chimica Acta. 83: 2183-2191. DOI: 10.1002/1522-2675(20000906)83:9<2183::Aid-Hlca2183>3.0.Co;2-C |
0.609 |
|
| 1999 |
Zhou ZS, Flohr A, Hilvert D. An Antibody-Catalyzed Allylic Sulfoxide-Sulfenate Rearrangement. The Journal of Organic Chemistry. 64: 8334-8341. PMID 11674756 DOI: 10.1021/Jo991299A |
0.537 |
|
| 1999 |
Dinakarpandian D, Shenoy BC, Hilvert D, McRee DE, McTigue M, Carey PR. Electric fields in active sites: Substrate switching from null to strong fields in thiol- and selenol-subtilisins Biochemistry. 38: 6659-6667. PMID 10350485 DOI: 10.1021/Bi9902541 |
0.323 |
|
| 1999 |
Mattei P, Kast P, Hilvert D. Bacillus subtilis chorismate mutase is partially diffusion-controlled. Febs Journal. 261: 25-32. PMID 10103029 DOI: 10.1046/J.1432-1327.1999.00169.X |
0.362 |
|
| 1998 |
MacBeath G, Kast P, Hilvert D. Probing enzyme quaternary structure by combinatorial mutagenesis and selection. Protein Science : a Publication of the Protein Society. 7: 1757-67. PMID 10082372 DOI: 10.1002/Pro.5560070810 |
0.638 |
|
| 1998 |
MacBeath G, Kast P, Hilvert D. A small, thermostable, and monofunctional chorismate mutase from the archaeon Methanococcus jannaschii. Biochemistry. 37: 10062-73. PMID 9665711 DOI: 10.1021/Bi980449T |
0.554 |
|
| 1998 |
MacBeath G, Kast P, Hilvert D. Exploring sequence constraints on an interhelical turn using in vivo selection for catalytic activity. Protein Science : a Publication of the Protein Society. 7: 325-35. PMID 9521108 DOI: 10.1002/Pro.5560070212 |
0.621 |
|
| 1998 |
MacBeath G, Kast P, Hilvert D. Redesigning enzyme topology by directed evolution. Science (New York, N.Y.). 279: 1958-61. PMID 9506949 DOI: 10.1126/Science.279.5358.1958 |
0.655 |
|
| 1997 |
Kast P, Hilvert D. 3D structural information as a guide to protein engineering using genetic selection. Current Opinion in Structural Biology. 7: 470-479. PMID 9266167 DOI: 10.1016/S0959-440X(97)80109-1 |
0.377 |
|
| 1997 |
Zhou ZS, Jiang N, Hilvert D. An Antibody-Catalyzed Selenoxide Elimination Journal of the American Chemical Society. 119: 3623-3624. DOI: 10.1021/Ja963748J |
0.492 |
|
| 1997 |
Peterson EB, Hilvert D. Selenosubtilisin's peroxidase activity does not require an intact oxyanion hole Tetrahedron. 53: 12311-12317. DOI: 10.1016/S0040-4020(97)00562-0 |
0.397 |
|
| 1996 |
MacBeath G, Hilvert D. Hydrolytic antibodies: variations on a theme. Chemistry & Biology. 3: 433-45. PMID 8807874 DOI: 10.1016/S1074-5521(96)90091-5 |
0.57 |
|
| 1996 |
Tang Y, Jiang N, Parakh C, Hilvert D. Selection of linkers for a catalytic single-chain antibody using phage display technology. Journal of Biological Chemistry. 271: 15682-15686. PMID 8663068 DOI: 10.1074/Jbc.271.26.15682 |
0.368 |
|
| 1996 |
Kast P, Asif-Ullah M, Jiang N, Hilvert D. Exploring the active site of chorismate mutase by combinatorial mutagenesis and selection: the importance of electrostatic catalysis Proceedings of the National Academy of Sciences of the United States of America. 93: 5043-5048. PMID 8643526 DOI: 10.1073/Pnas.93.10.5043 |
0.418 |
|
| 1996 |
Kast P, Hilvert D. Genetic selection strategies for generating and characterizing catalysts Pure and Applied Chemistry. 68: 2017-2024. DOI: 10.1351/Pac199668112017 |
0.326 |
|
| 1996 |
Na J, Houk KN, Hilvert D. Transition state of the base-promoted ring-opening of isoxazoles. Theoretical prediction of catalytic functionalities and design of haptens for antibody production Journal of the American Chemical Society. 118: 6462-6471. DOI: 10.1021/Ja953550J |
0.34 |
|
| 1996 |
O'Connor MJ, Dunlap RB, Odom JD, Hilvert D, Pusztai-Carey M, Shenoy BC, Carey PR. Probing an acyl enzyme of selenosubtilisin by raman spectroscopy Journal of the American Chemical Society. 118: 239-240. DOI: 10.1021/Ja952981Z |
0.31 |
|
| 1996 |
Kast P, Asif-Ullah M, Hilvert D. Is chorismate mutase a prototypic entropy trap? - Activation parameters for the Bacillus subtilis enzyme Tetrahedron Letters. 37: 2691-2694. DOI: 10.1016/0040-4039(96)00338-3 |
0.337 |
|
| 1996 |
Haynes MR, Lenz M, Taussig MJ, Wilson IA, Hilvert D. Sequence Similarity and Cross-Reactivity of a Diels-Alder Catalyst and an Anti-Progesterone Antibody Israel Journal of Chemistry. 36: 151-159. DOI: 10.1002/Ijch.199600021 |
0.371 |
|
| 1995 |
Thorn SN, Daniels RG, Auditor MM, Hilvert D. Large rate accelerations in antibody catalysis by strategic use of haptenic charge Nature. 373: 228-230. PMID 7816136 DOI: 10.1038/373228A0 |
0.396 |
|
| 1995 |
Peterson EB, Hilvert D. Nonessential active site residues modulate selenosubtilisin's kinetic mechanism. Biochemistry. 34: 6616-20. PMID 7756293 DOI: 10.1021/Bi00020A006 |
0.414 |
|
| 1994 |
Hilvert D. Chemical synthesis of proteins Chemistry & Biology. 1: 201-203. PMID 9383391 DOI: 10.1016/1074-5521(94)90011-6 |
0.378 |
|
| 1994 |
Haynes MR, Stura EA, Hilvert D, Wilson IA. Routes to catalysis: structure of a catalytic antibody and comparison with its natural counterpart. Science (New York, N.Y.). 263: 646-52. PMID 8303271 DOI: 10.1126/Science.8303271 |
0.395 |
|
| 1994 |
MacBeath G, Hilvert D. Monitoring Catalytic Activity by Immunoassay: Implications for Screening Journal of the American Chemical Society. 116: 6101-6106. DOI: 10.1021/Ja00093A006 |
0.526 |
|
| 1993 |
Syed R, Wu ZP, Hogle JM, Hilvert D. Crystal structure of selenosubtilisin at 2.0-A resolution. Biochemistry. 32: 6157-64. PMID 8512925 DOI: 10.1021/Bi00075A007 |
0.458 |
|
| 1993 |
Bell IM, Fisher ML, Wu ZP, Hilvert D. Kinetic studies on the peroxidase activity of selenosubtilisin. Biochemistry. 32: 3754-62. PMID 8385489 DOI: 10.1021/Bi00065A030 |
0.415 |
|
| 1993 |
Campbell AP, Tarasow TM, Massefski W, Wright PE, Hilvert D. Binding of a high-energy substrate conformer in antibody catalysis. Proceedings of the National Academy of Sciences of the United States of America. 90: 8663-7. PMID 8378345 DOI: 10.1073/Pnas.90.18.8663 |
0.373 |
|
| 1993 |
Bell IM, Hilvert D. Peroxide dependence of the semisynthetic enzyme selenosubtilisin. Biochemistry. 32: 13969-13973. PMID 8268174 DOI: 10.1021/Bi00213A029 |
0.395 |
|
| 1993 |
Lewis C, Paneth P, O'Leary MH, Hilvert D. Carbon kinetic isotope effects on the spontaneous and antibody-catalyzed decarboxylation of 5-nitro-3-carboxybenzisoxazole Journal of the American Chemical Society. 115: 1410-1413. DOI: 10.1021/Ja00057A025 |
0.326 |
|
| 1992 |
House KL, Dunlap RB, Odom JD, Wu ZP, Hilvert D. Structural characterization of selenosubtilisin by selenium-77 NMR spectroscopy Journal of the American Chemical Society. 114: 8573-8579. DOI: 10.1021/Ja00048A033 |
0.335 |
|
| 1991 |
Tang Y, Hicks JB, Hilvert D. In vivo catalysis of a metabolically essential reaction by an antibody. Proceedings of the National Academy of Sciences of the United States of America. 88: 8784-8786. PMID 1924339 DOI: 10.1073/Pnas.88.19.8784 |
0.37 |
|
| 1991 |
Hilvert D, Hill KW. Antibody catalysis of concerted, carbon-carbon bond-forming reactions. Methods in Enzymology. 203: 352-369. PMID 1762564 DOI: 10.1016/0076-6879(91)03020-H |
0.407 |
|
| 1990 |
Wu ZP, Hilvert D. Selenosubtilisin as a glutathione peroxidase mimic Journal of the American Chemical Society. 112: 5647-5648. DOI: 10.1021/Ja00170A043 |
0.304 |
|
| 1989 |
Wu ZP, Hilvert D. Conversion of a protease into an acyl transferase: selenolsubtilisin Journal of the American Chemical Society. 111: 4513-4514. DOI: 10.1021/Ja00194A064 |
0.342 |
|
| 1988 |
Hilvert D, Hatanaka Y, Kaiser ET. A highly active thermophilic semisynthetic flavoenzyme Journal of the American Chemical Society. 110: 682-689. DOI: 10.1021/Ja00211A004 |
0.522 |
|
| 1986 |
Hilvert D, Gardell SJ, Rutter WJ, Kaiser ET. Evidence against a crucial role for the phenolic hydroxyl of Tyr-248 in peptide and ester hydrolyses catalyzed by carboxypeptidase A: Comparative studies of the pH dependencies of the native and Phe-248-mutant forms Journal of the American Chemical Society. 108: 5298-5304. DOI: 10.1002/Chin.198652064 |
0.533 |
|
| 1985 |
Hilvert D, Kaiser ET. New semisynthetic flavoenzymes based on a tetrameric protein template, glyceraldehyde-3-phosphate dehydrogenase Journal of the American Chemical Society. 107: 5805-5806. DOI: 10.1021/Ja00306A040 |
0.556 |
|
| 1983 |
Breslow R, Chin J, Hilvert D, Trainor G. Evidence for the general base mechanism in carboxypeptidase A-catalyzed reactions: partitioning studies on nucleophiles and H2(18)O kinetic isotope effects Proceedings of the National Academy of Sciences of the United States of America. 80: 4585-4589. PMID 6576353 DOI: 10.1073/Pnas.80.14.4585 |
0.5 |
|
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