Peter A. Jones, PhD - Publications

Affiliations: 
University of Southern California University of Southern California, Los Angeles, CA, United States 
Area:
DNA methylation, cancer, epigenetics

301 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Tiedemann RL, Hrit J, Du Q, Wiseman AK, Eden HE, Dickson BM, Kong X, Chomiak AA, Vaughan RM, Hebert JM, David Y, Zhou W, Baylin SB, Jones PA, Clark SJ, et al. UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation. Biorxiv : the Preprint Server For Biology. PMID 38405904 DOI: 10.1101/2024.02.13.580169  0.446
2023 Thomas SL, Xu TH, Carpenter BL, Pierce SE, Dickson BM, Liu M, Liang G, Jones PA. DNA strand asymmetry generated by CpG hemimethylation has opposing effects on CTCF binding. Nucleic Acids Research. PMID 37094063 DOI: 10.1093/nar/gkad293  0.346
2023 Li HT, Jang HJ, Rohena-Rivera K, Liu M, Gujar H, Kulchycki J, Zhao S, Billet S, Zhou X, Weisenberger DJ, Gill I, Jones PA, Bhowmick NA, Liang G. RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer. Cell Reports. 42: 112016. PMID 36662621 DOI: 10.1016/j.celrep.2023.112016  0.353
2022 Zhang L, Li HT, Shereda R, Lu Q, Weisenberger DJ, O'Connell C, Machida K, An W, Lenz HJ, El-Khoueiry A, Jones PA, Liu M, Liang G. DNMT and EZH2 inhibitors synergize to activate therapeutic targets in hepatocellular carcinoma. Cancer Letters. 215899. PMID 36087682 DOI: 10.1016/j.canlet.2022.215899  0.301
2022 Zhou W, Hinoue T, Barnes B, Mitchell O, Iqbal W, Lee SM, Foy KK, Lee KH, Moyer EJ, VanderArk A, Koeman JM, Ding W, Kalkat M, Spix NJ, Eagleson B, ... ... Jones PA, et al. DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse. Cell Genomics. 2. PMID 35873672 DOI: 10.1016/j.xgen.2022.100144  0.424
2022 Wiseman AK, Tiedemann RL, Fan H, Shen H, Madaj Z, McCabe MT, Pappalardi MB, Jones PA. Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1. Communications Biology. 5: 528. PMID 35654826 DOI: 10.1038/s42003-022-03509-3  0.443
2021 Pappalardi MB, Keenan K, Cockerill M, Kellner WA, Stowell A, Sherk C, Wong K, Pathuri S, Briand J, Steidel M, Chapman P, Groy A, Wiseman AK, McHugh CF, Campobasso N, ... ... Jones PA, et al. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nature Cancer. 2: 1002-1017. PMID 34790902  0.451
2020 Xu TH, Liu M, Zhou XE, Liang G, Zhao G, Xu HE, Melcher K, Jones PA. Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B. Nature. PMID 32968275 DOI: 10.1038/s41586-020-2747-1  0.392
2020 Zhou W, Liang G, Molloy PL, Jones PA. DNA methylation enables transposable element-driven genome expansion. Proceedings of the National Academy of Sciences of the United States of America. PMID 32719115 DOI: 10.1073/Pnas.1921719117  0.45
2020 Ohtani H, Ørskov AD, Helbo AS, Gillberg L, Liu M, Zhou W, Ungerstedt J, Hellström-Lindberg E, Sun W, Liang G, Jones PA, Grønbæk K. Activation of a Subset of Evolutionarily Young Transposable Elements and Innate Immunity are Linked to Clinical Responses to 5-Azacytidine. Cancer Research. PMID 32245794 DOI: 10.1158/0008-5472.Can-19-1696  0.358
2020 Tiedemann RL, Du Q, Dickson BM, Kong X, Chomiak AA, Zhou W, Johnson BK, Baylin SB, Jones PA, Clark SJ, Rothbart SB. High‐resolution Epigenome Mapping Reveals Distinct and Divergent Roles for UHRF1 in the Maintenance of DNA Methylation The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05966  0.457
2019 Jones PA, Ohtani H, Chakravarthy A, De Carvalho DD. Epigenetic therapy in immune-oncology. Nature Reviews. Cancer. PMID 30723290 DOI: 10.1038/S41568-019-0109-9  0.548
2019 Ohtani H, Ørskov AD, Helbo AS, Gillberg L, Liu M, Zhou W, Ungerstedt J, Hellstrom-Lindberg E, Sun W, Liang G, Jones PA, Grønbæk K. Abstract 3092: Activation of evolutionarily young transposable elements and the host innate immune system are linked to clinical response to 5-azacitidine Cancer Research. 79: 3092-3092. DOI: 10.1158/1538-7445.Am2019-3092  0.378
2018 Carpenter BL, Zhou W, Madaj Z, DeWitt AK, Ross JP, Grønbæk K, Liang G, Clark SJ, Molloy PL, Jones PA. Mother-child transmission of epigenetic information by tunable polymorphic imprinting. Proceedings of the National Academy of Sciences of the United States of America. PMID 30509985 DOI: 10.1073/Pnas.1815005115  0.402
2018 Liu M, Thomas SL, DeWitt AK, Zhou W, Madaj ZB, Ohtani H, Baylin SB, Liang G, Jones PA. Dual inhibition of DNA and histone methyltransferases increases viral mimicry in ovarian cancer cells. Cancer Research. PMID 30185548 DOI: 10.1158/0008-5472.Can-17-3953  0.48
2018 Lee V, Wang JS, Zahurak ML, Gootjes EC, Verheul HMW, Parkinson RM, Kerner Z, Sharma A, Rosner GL, De Jesus-Acosta A, Laheru DA, Le DT, Oganesian A, Lilly-Foreman E, Brown T, ... Jones PA, et al. A phase I trial of a guadecitabine (SGI-110) and irinotecan in metastatic colorectal cancer patients previously exposed to irinotecan. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30097434 DOI: 10.1158/1078-0432.Ccr-18-0421  0.347
2018 Ohtani H, Liu M, Zhou W, Liang G, Jones PA. Switching roles for DNA and histone methylation depend on evolutionary ages of human endogenous retroviruses. Genome Research. PMID 29970451 DOI: 10.1101/Gr.234229.118  0.549
2018 Sun W, Triche T, Malvar J, Gaynon P, Sposto R, Yang X, Bittencourt H, Place AE, Messinger Y, Fraser C, Dalla-Pozza L, Salhia B, Jones P, Wayne AS, Gore L, et al. A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from TACL consortium. Blood. PMID 29339403 DOI: 10.1182/Blood-2017-09-803809  0.347
2018 Lay FD, Kelly TK, Jones PA. Nucleosome Occupancy and Methylome Sequencing (NOMe-seq). Methods in Molecular Biology (Clifton, N.J.). 1708: 267-284. PMID 29224149 DOI: 10.1007/978-1-4939-7481-8_14  0.518
2018 Hostetter G, Minmin L, Mustert M, Berghuis B, Turner L, Jones P, Baylin S, Jewell S, Sempere L. Abstract A39: Viral response markers in immune-competent solid tumors by immunohistochemistry Cancer Immunology Research. 6. DOI: 10.1158/2326-6074.Tumimm17-A39  0.312
2018 Ohtani H, Liu M, Zhou W, Liang G, Jones PA. Abstract 2993: A switch in epigenetic silencing mechanisms of endogenous retroviruses during human genome evolution Cancer Research. 78: 2993-2993. DOI: 10.1158/1538-7445.Am2018-2993  0.56
2018 Nishiyama N, Shinkai N, Yi S, Duymich CE, Shindo T, Jones PA, Suzuki H, Masumori N, Liang G. MP54-19 DNA METHYLATION INHIBITORS COULD RE-SENSITIZE DRUG-RESISTANCE BLADDER CANCER CELLS IN VITRO AND IN VIVO Journal of Urology. 199. DOI: 10.1016/J.Juro.2018.02.1710  0.488
2017 Choi SK, Pandiyan K, Eun JW, Yang X, Hong SH, Nam SW, Jones PA, Liang G, You JS. Epigenetic landscape change analysis during human EMT sheds light on a key EMT mediator TRIM29. Oncotarget. 8: 98322-98335. PMID 29228692 DOI: 10.18632/Oncotarget.21681  0.515
2017 Gillberg L, Ørskov AD, Liu M, Harsløf LBS, Jones PA, Grønbæk K. Vitamin C - a new player in regulation of the cancer epigenome. Seminars in Cancer Biology. PMID 29102482 DOI: 10.1016/J.Semcancer.2017.11.001  0.402
2017 Lakshminarasimhan R, Andreu-Vieyra C, Lawrenson K, Duymich CE, Gayther SA, Liang G, Jones PA. Down-regulation of ARID1A is sufficient to initiate neoplastic transformation along with epigenetic reprogramming in non-tumorigenic endometriotic cells. Cancer Letters. PMID 28483516 DOI: 10.1016/J.Canlet.2017.04.040  0.456
2017 Hall LL, Byron M, Carone DM, Whitfield TW, Pouliot GP, Fischer A, Jones P, Lawrence JB. Demethylated HSATII DNA and HSATII RNA Foci Sequester PRC1 and MeCP2 into Cancer-Specific Nuclear Bodies. Cell Reports. 18: 2943-2956. PMID 28329686 DOI: 10.1016/J.Celrep.2017.02.072  0.306
2017 Vincent M, Mundbjerg K, Skou Pedersen J, Liang G, Jones PA, Ørntoft TF, Dalsgaard Sørensen K, Wiuf C. epiG: statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data. Genome Biology. 18: 38. PMID 28222791 DOI: 10.1186/S13059-017-1168-4  0.499
2017 Azad NS, El-Khoueiry A, Yin J, Oberg AL, Flynn P, Adkins D, Sharma A, Weisenberger DJ, Brown T, Medvari P, Jones PA, Easwaran H, Kamel I, Bahary N, Kim G, et al. Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat; a phase 2 consortium/stand Up 2 cancer study. Oncotarget. PMID 28186961 DOI: 10.18632/Oncotarget.15108  0.439
2017 Helbo AS, Lay FD, Jones PA, Liang G, Grønbæk K. Nucleosome Positioning and NDR Structure at RNA Polymerase III Promoters. Scientific Reports. 7: 41947. PMID 28176797 DOI: 10.1038/Srep41947  0.44
2017 Kirsten G, Orskov AD, Ohtani H, Treppendahl M, Liu M, Hansen JW, Saini SK, Baylin SB, O'Connell C, Liang G, Hadrup SR, Jones PA. Modulation of the Immune System by Epigenetic Therapy: A Rationale for Combined Use of DNA Methyltransferase Inhibitors and Immune Checkpoint Inhibitors Annals of Hematology. 96. PMID 28105492 DOI: 10.1007/S00277-017-2921-1  0.327
2017 Mundbjerg K, Chopra S, Alemozaffar M, Duymich C, Lakshminarasimhan R, Nichols PW, Aron M, Siegmund KD, Ukimura O, Aron M, Stern M, Gill P, Carpten JD, Ørntoft TF, Sørensen KD, ... ... Jones PA, et al. Identifying aggressive prostate cancer foci using a DNA methylation classifier. Genome Biology. 18: 3. PMID 28081708 DOI: 10.1186/S13059-016-1129-3  0.36
2017 Jones PA. Abstract IA14: Targeting human endogenous retroviruses for epigenetic therapy Cancer Research. 77. DOI: 10.1158/1538-7445.Newfront17-Ia14  0.392
2017 Ørskov A, Saini S, Bjerregaard A, Otani H, Holmberg S, Treppendahl M, Gang A, Dufva I, Liang G, Eklund A, Jones P, Grønbæk K, Hadrup S. Induction of Antigen-Specific T Cells Targeting Endogenous Retroelements During Epigenetic Treatment of Myelodysplastic Syndrome Leukemia Research. 55: S66-S67. DOI: 10.1016/S0145-2126(17)30220-5  0.302
2017 Shinkai N, Nishiyama N, Yi S, Duymich CE, Shindo T, Jones PA, Suzuki H, Masumori N, Liang G. MP98-02 A POTENTIAL ROLE OF ABERRANT DNA METHYLATION IN THE CHEMORESISTANCE IN BLADDER CANCER CELLS. DNA METHYLATION INHIBITORS COULD RE-SENSITIZE DRUG-RESISTANCE BLADDER CANCER CELLS. Journal of Urology. 197. DOI: 10.1016/J.Juro.2017.02.3067  0.541
2016 Connolly R, Li H, Jankowitz RC, Zhang Z, Rudek MA, Jeter SC, Slater S, Powers P, Wolff AC, Fetting JH, Brufsky AM, Piekarz R, Ahuja N, Laird PW, Shen H, ... ... Jones PA, et al. Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27979916 DOI: 10.1158/1078-0432.Ccr-16-1729  0.381
2016 Jones PA, Issa JJ, Baylin S. Targeting the cancer epigenome for therapy. Nature Reviews. Genetics. 17: 630-641. PMID 27629931 DOI: 10.1038/Nrg.2016.93  0.431
2016 Liu M, Ohtani H, Zhou W, Ørskov AD, Charlet J, Zhang YW, Shen H, Baylin SB, Liang G, Grønbæk K, Jones PA. Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine. Proceedings of the National Academy of Sciences of the United States of America. PMID 27573823 DOI: 10.1073/Pnas.1612262113  0.339
2016 Baylin SB, Jones PA. Epigenetic Determinants of Cancer. Cold Spring Harbor Perspectives in Biology. PMID 27194046 DOI: 10.1101/Cshperspect.A019505  0.5
2016 Charlet J, Duymich CE, Lay FD, Mundbjerg K, Dalsgaard Sørensen K, Liang G, Jones PA. Bivalent Regions of Cytosine Methylation and H3K27 Acetylation Suggest an Active Role for DNA Methylation at Enhancers. Molecular Cell. 62: 422-31. PMID 27153539 DOI: 10.1016/J.Molcel.2016.03.033  0.533
2016 Duymich CE, Charlet J, Yang X, Jones PA, Liang G. DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells. Nature Communications. 7: 11453. PMID 27121154 DOI: 10.1038/Ncomms11453  0.54
2016 Becket E, Chopra S, Duymich CE, Lin JJ, You JS, Pandiyan K, Nichols PW, Siegmund KD, Charlet J, Weisenberger DJ, Jones PA, Liang G. Identification of DNA methylation-independent epigenetic events underlying clear cell renal cell carcinoma. Cancer Research. PMID 26759245 DOI: 10.1158/0008-5472.Can-15-2622  0.585
2016 Jones PA. Abstract IA04: How DNA methylation organizes the cancer epigenome Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-Ia04  0.568
2016 Becket E, Chopra S, Duymich C, Justin LJ, You JS, Pandiyan K, Nichols PW, Siegmund KD, Jones PA, Liang G. Abstract B03: Identification of epigenetic regulated genes through simultaneous analysis of DNA methylation and chromatin structure in uncultured tumors Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-B03  0.581
2016 Lakshminarasimhan R, Andreu-Vieyra C, Lawrenson K, Gayther SA, Jones PA, Liang G. Abstract B02: The role of chromatin remodeler protein ARID1a in ovarian clear cell carcinoma Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-B02  0.526
2016 Nishiyama N, Yi S, Duymich CE, Daneshmand S, Jones PA, Djaladat H, Masumori N, Liang G. MP61-10 DNA METHYLATION INHIBITORS MAY REVERSE DRUG-RESISTANCE IN HUMAN BLADDER CANCER CELLS Journal of Urology. 195. DOI: 10.1016/J.Juro.2016.02.884  0.496
2015 Statham AL, Taberlay PC, Kelly TK, Jones PA, Clark SJ. Genome-wide nucleosome occupancy and DNA methylation profiling of four human cell lines. Genomics Data. 3: 94-6. PMID 26484155 DOI: 10.1016/J.Gdata.2014.11.012  0.564
2015 Roulois D, Loo Yau H, Singhania R, Wang Y, Danesh A, Shen SY, Han H, Liang G, Jones PA, Pugh TJ, O'Brien C, De Carvalho DD. DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts. Cell. 162: 961-73. PMID 26317465 DOI: 10.1016/J.Cell.2015.07.056  0.575
2015 Lay FD, Liu Y, Kelly TK, Witt H, Farnham PJ, Jones PA, Berman BP. The role of DNA methylation in directing the functional organization of the cancer epigenome. Genome Research. 25: 467-77. PMID 25747664 DOI: 10.1101/Gr.183368.114  0.678
2015 Morgan MK, Jones PA, Sobus JR, Chuang JC, Wilson NK. Using urinary biomarkers to evaluate polycyclic aromatic hydrocarbon exposure in 126 preschool children in Ohio. International Journal of Environmental Health Research. 1-12. PMID 25614176 DOI: 10.1080/09603123.2014.1003039  0.496
2015 Becket EC, Duymich C, Chang Y, Pandiyan K, Nichols P, Jones P, Gill I, Liang G. Abstract A1-05: Elucidation of epigenetic driver genes in clear cell renal cell carcinoma using a newly developed assay, AcceSssIble Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A1-05  0.545
2015 Statham AL, Taberlay PC, Kelly TK, Jones PA, Clark SJ. Genome-wide nucleosome occupancy and DNA methylation profiling of four human cell lines Genomics Data. 3: 94-96. DOI: 10.1016/j.gdata.2014.11.012  0.397
2014 Yang X, Han H, De Carvalho DD, Lay FD, Jones PA, Liang G. Gene body methylation can alter gene expression and is a therapeutic target in cancer. Cancer Cell. 26: 577-90. PMID 25263941 DOI: 10.1016/J.Ccr.2014.07.028  0.632
2014 Taberlay PC, Statham AL, Kelly TK, Clark SJ, Jones PA. Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer. Genome Research. 24: 1421-32. PMID 24916973 DOI: 10.1101/Gr.163485.113  0.513
2014 Su SF, de Castro Abreu AL, Chihara Y, Tsai Y, Andreu-Vieyra C, Daneshmand S, Skinner EC, Jones PA, Siegmund KD, Liang G. A panel of three markers hyper- and hypomethylated in urine sediments accurately predicts bladder cancer recurrence. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 1978-89. PMID 24691641 DOI: 10.1158/1078-0432.Ccr-13-2637  0.583
2014 Li H, Chiappinelli KB, Guzzetta AA, Easwaran H, Yen RW, Vatapalli R, Topper MJ, Luo J, Connolly RM, Azad NS, Stearns V, Pardoll DM, Davidson N, Jones PA, Slamon DJ, et al. Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers. Oncotarget. 5: 587-98. PMID 24583822 DOI: 10.18632/Oncotarget.1782  0.5
2014 Lay FD, Triche TJ, Tsai YC, Su SF, Martin SE, Daneshmand S, Skinner EC, Liang G, Chihara Y, Jones PA. Reprogramming of the human intestinal epigenome by surgical tissue transposition. Genome Research. 24: 545-53. PMID 24515120 DOI: 10.1101/Gr.166439.113  0.618
2014 Jones PA. At the tipping point for epigenetic therapies in cancer. The Journal of Clinical Investigation. 124: 14-6. PMID 24382384 DOI: 10.1172/Jci74145  0.507
2014 Pedersen JS, Valen E, Velazquez AM, Parker BJ, Rasmussen M, Lindgreen S, Lilje B, Tobin DJ, Kelly TK, Vang S, Andersson R, Jones PA, Hoover CA, Tikhonov A, Prokhortchouk E, et al. Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome. Genome Research. 24: 454-66. PMID 24299735 DOI: 10.1101/Gr.163592.113  0.438
2014 Jeong KW, Andreu-Vieyra C, You JS, Jones PA, Stallcup MR. Establishment of active chromatin structure at enhancer elements by mixed-lineage leukemia 1 to initiate estrogen-dependent gene expression. Nucleic Acids Research. 42: 2245-56. PMID 24288367 DOI: 10.1093/Nar/Gkt1236  0.471
2014 Sun W, Gaynon PS, Sposto R, Bittencourt H, Place AE, Messinger YH, Fraser C, Dalla-Pozza L, Giessen Jvd, Eckroth E, Yang X, Liang G, Jones PA, Wayne AS, Cooper T. A Phase 1 Study of Azacitidine (AZA) in Combination with Fludarabine and Cytarabine in Relapse/Refractory Childhood Leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study Blood. 124: 3764-3764. DOI: 10.1182/Blood.V124.21.3764.3764  0.353
2014 Becket E, Duymich C, Chang Y, Pandiyan K, Jones PA, Liang G. Abstract LB-130: Simultaneous evaluation of chromatin accessibility and DNA methylation in clear cell renal cell carcinoma by a newly developed assay, AcceSssIble Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-130  0.548
2014 Lay FD, Liu Y, Kelly TK, Witt H, Blattler A, Farnham PJ, Berman BP, Jones PA. Abstract 4780: The effects of the global loss of DNA methylation on the functional organization of the epigenome Cancer Research. 74: 4780-4780. DOI: 10.1158/1538-7445.Am2014-4780  0.679
2014 Jones P. 3: The cancer epigenome European Journal of Cancer. 50. DOI: 10.1016/S0959-8049(14)50003-2  0.345
2013 Wrangle J, Wang W, Koch A, Easwaran H, Mohammad HP, Vendetti F, Vancriekinge W, Demeyer T, Du Z, Parsana P, Rodgers K, Yen RW, Zahnow CA, Taube JM, Brahmer JR, ... ... Jones PA, et al. Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine. Oncotarget. 4: 2067-79. PMID 24162015 DOI: 10.18632/Oncotarget.1542  0.367
2013 Choi IS, Yu K, Kim J, De Guzman E, Weisenberger DJ, Oghamian S, Kim HJ, Lee KH, Carroll C, Trinh BN, Kim M, Houshdaran S, Laird PW, Jones PA, Warburton D, et al. Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model. Urology. 82: 253.e9-15. PMID 23806407 DOI: 10.1016/J.Urology.2013.04.010  0.462
2013 Chihara Y, Kanai Y, Fujimoto H, Sugano K, Kawashima K, Liang G, Jones PA, Fujimoto K, Kuniyasu H, Hirao Y. Diagnostic markers of urothelial cancer based on DNA methylation analysis. Bmc Cancer. 13: 275. PMID 23735005 DOI: 10.1186/1471-2407-13-275  0.484
2013 You JS, De Carvalho DD, Dai C, Liu M, Pandiyan K, Zhou XJ, Liang G, Jones PA. SNF5 is an essential executor of epigenetic regulation during differentiation. Plos Genetics. 9: e1003459. PMID 23637628 DOI: 10.1371/Journal.Pgen.1003459  0.471
2013 Pandiyan K, You JS, Yang X, Dai C, Zhou XJ, Baylin SB, Jones PA, Liang G. Functional DNA demethylation is accompanied by chromatin accessibility. Nucleic Acids Research. 41: 3973-85. PMID 23408854 DOI: 10.1093/Nar/Gkt077  0.585
2013 Morgan GT, Jones P, Bellini M. Association of modified cytosines and the methylated DNA-binding protein MeCP2 with distinctive structural domains of lampbrush chromatin. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 20: 925-42. PMID 23149574 DOI: 10.1007/s10577-012-9324-x  0.335
2013 Jones PA. Genome wide analysis of DNA methylation and nucleosome positioning Epigenetics & Chromatin. 6. DOI: 10.1186/1756-8935-6-S1-O37  0.544
2013 You JS, Carvalho DDD, Dai C, Liu M, Pandiyan K, Zhou X, Liang G, Jones PA. Abstract PR07: SNF5 is an essential executor of epigenetic regulation during differentiation Cancer Research. 73. DOI: 10.1158/1538-7445.Cec13-Pr07  0.485
2013 Jones PA. Abstract IA16: Reactivating epigenetically silenced genes Cancer Research. 73. DOI: 10.1158/1538-7445.Cec13-Ia16  0.521
2013 Zhang HH, Yang X, Carvalho DDD, Jones PA, Liang G. Abstract B56: DNA demethylation in gene bodies is of therapeutic significance Cancer Research. 73. DOI: 10.1158/1538-7445.Cec13-B56  0.524
2013 Duymich CE, Charlet J, Liang G, Jones PA. Abstract A11: Role of chromatin remodeler mutations in urothelial cell carcinoma of the bladder Cancer Research. 73. DOI: 10.1158/1538-7445.Cec13-A11  0.533
2013 Liang G, Han H, Carvalho DDD, Yang X, Jones PA. Abstract 677: Transient exposure to decitabine results in sustained cell growth inhibition and long term DNA demethylation at specific loci. Cancer Research. 73: 677-677. DOI: 10.1158/1538-7445.Am2013-677  0.69
2013 Yang X, Han H, Treppendahl MB, Tsai YC, O'Connell C, Weisenberger D, Lay F, Grønbæk K, Liang G, Jones PA. Abstract 4624: Identification of novel DNA methylation markers to track patient's response to DNA demethylation agents. Cancer Research. 73: 4624-4624. DOI: 10.1158/1538-7445.Am2013-4624  0.662
2013 Wrangle J, Wang W, Koch A, Easwaran H, Mohammad H, Parsana P, Vendetti F, Rodgers K, Pan X, Harbom K, Zahnow C, Taube J, Brahmer J, Jones P, Topalian S, et al. Abstract 4619: Epigenetic therapy and sensitization of lung cancer to immunotherapy. Cancer Research. 73: 4619-4619. DOI: 10.1158/1538-7445.Am2013-4619  0.446
2013 Abreu ALdC, Su S, Siegmund K, Tsai Y, Chihara Y, Skinner E, Daneshmand S, Jones PA, Liang G. 1699 Identifying Novel Dna Methylation Markers To Monitor Bladder Cancer Recurrence In Urine Sediments From Turbt Patients The Journal of Urology. 189. DOI: 10.1016/J.Juro.2013.02.3009  0.552
2012 Beck S, Bernstein BE, Campbell RM, Costello JF, Dhanak D, Ecker JR, Greally JM, Issa JP, Laird PW, Polyak K, Tycko B, Jones PA. A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force. Cancer Research. 72: 6319-24. PMID 23188507 DOI: 10.1158/0008-5472.Can-12-3658  0.36
2012 Kelly TK, Liu Y, Lay FD, Liang G, Berman BP, Jones PA. Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules. Genome Research. 22: 2497-506. PMID 22960375 DOI: 10.1101/Gr.143008.112  0.64
2012 You JS, Jones PA. Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell. 22: 9-20. PMID 22789535 DOI: 10.1016/J.Ccr.2012.06.008  0.498
2012 Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nature Reviews. Genetics. 13: 484-92. PMID 22641018 DOI: 10.1038/Nrg3230  0.544
2012 De Carvalho DD, Sharma S, You JS, Su SF, Taberlay PC, Kelly TK, Yang X, Liang G, Jones PA. DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell. 21: 655-67. PMID 22624715 DOI: 10.1016/J.Ccr.2012.03.045  0.773
2012 Yang X, Noushmehr H, Han H, Andreu-Vieyra C, Liang G, Jones PA. Gene reactivation by 5-aza-2'-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions. Plos Genetics. 8: e1002604. PMID 22479200 DOI: 10.1371/Journal.Pgen.1002604  0.654
2012 Sharma S, Gerke DS, Han HF, Jeong S, Stallcup MR, Jones PA, Liang G. Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells. Epigenetics & Chromatin. 5: 3. PMID 22284370 DOI: 10.1186/1756-8935-5-3  0.709
2012 Treppendahl MB, Qiu X, Søgaard A, Yang X, Nandrup-Bus C, Hother C, Andersen MK, Kjeldsen L, MöllgÃ¥rd L, Möllgaard L, Hellström-Lindberg E, Jendholm J, Porse BT, Jones PA, Liang G, et al. Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML. Blood. 119: 206-16. PMID 22058117 DOI: 10.1182/Blood-2011-06-362541  0.428
2012 Jones PA. Decoding the Chromatin Code Blood. 120: SCI-4-SCI-4. DOI: 10.1182/Blood.V120.21.Sci-4.Sci-4  0.529
2011 Taberlay PC, Kelly TK, Liu CC, You JS, De Carvalho DD, Miranda TB, Zhou XJ, Liang G, Jones PA. Polycomb-repressed genes have permissive enhancers that initiate reprogramming. Cell. 147: 1283-94. PMID 22153073 DOI: 10.1016/J.Cell.2011.10.040  0.399
2011 Andreu-Vieyra C, Lai J, Berman BP, Frenkel B, Jia L, Jones PA, Coetzee GA. Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells. Molecular and Cellular Biology. 31: 4648-62. PMID 21969603 DOI: 10.1128/Mcb.05934-11  0.383
2011 Baylin SB, Jones PA. A decade of exploring the cancer epigenome - biological and translational implications. Nature Reviews. Cancer. 11: 726-34. PMID 21941284 DOI: 10.1038/Nrc3130  0.508
2011 You JS, Kelly TK, De Carvalho DD, Taberlay PC, Liang G, Jones PA. OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes. Proceedings of the National Academy of Sciences of the United States of America. 108: 14497-502. PMID 21844352 DOI: 10.1073/Pnas.1111309108  0.527
2011 Han H, Cortez CC, Yang X, Nichols PW, Jones PA, Liang G. DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter. Human Molecular Genetics. 20: 4299-310. PMID 21835883 DOI: 10.1093/Hmg/Ddr356  0.821
2011 Morgan MK, Jones PA, Calafat AM, Ye X, Croghan CW, Chuang JC, Wilson NK, Clifton MS, Figueroa Z, Sheldon LS. Assessing the quantitative relationships between preschool children's exposures to bisphenol A by route and urinary biomonitoring. Environmental Science & Technology. 45: 5309-16. PMID 21612268 DOI: 10.1021/es200537u  0.483
2011 Molognoni F, Cruz AT, Meliso FM, Morais AS, Souza CF, Xander P, Bischof JM, Costa FF, Soares MB, Liang G, Jones PA, Jasiulionis MG. Epigenetic reprogramming as a key contributor to melanocyte malignant transformation. Epigenetics : Official Journal of the Dna Methylation Society. 6: 450-64. PMID 21343701 DOI: 10.4161/Epi.6.4.14917  0.442
2011 Sharma S, De Carvalho DD, Jeong S, Jones PA, Liang G. Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. Plos Genetics. 7: e1001286. PMID 21304883 DOI: 10.1371/Journal.Pgen.1001286  0.644
2011 Kelly TK, Jones PA. Role of nucleosomes in mitotic bookmarking. Cell Cycle (Georgetown, Tex.). 10: 370-1. PMID 21270523 DOI: 10.4161/Cc.10.3.14734  0.306
2011 Jones P. Out of Africa and into epigenetics: discovering reprogramming drugs. Nature Cell Biology. 13: 2. PMID 21173799 DOI: 10.1038/Ncb0111-2  0.306
2011 Taberlay PC, Jones PA. DNA methylation and cancer. Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progrã¨S Des Recherches Pharmaceutiques. 67: 1-23. PMID 21141722 DOI: 10.1007/978-3-7643-8989-5_1  0.588
2011 Morgan MK, Sheldon LS, Jones PA, Croghan CW, Chuang JC, Wilson NK. The reliability of using urinary biomarkers to estimate children's exposures to chlorpyrifos and diazinon. Journal of Exposure Science & Environmental Epidemiology. 21: 280-90. PMID 20502492 DOI: 10.1038/jes.2010.11  0.501
2011 Jones PA. Abstract IA20: DNA methylation and nucleosome repositioning in cancer Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-Ia20  0.571
2011 Molognoni F, Monteiro AC, Morais AS, Souza CF, Cruz AT, Melisso FM, Liang G, Jones PA, Jasiulionis MG. Abstract 2004: Effect of epigenetic drugs on melanocytes and melanoma cell lines phenotype and aggressiveness Cancer Research. 71: 2004-2004. DOI: 10.1158/1538-7445.Am2011-2004  0.46
2010 Kelly TK, De Carvalho DD, Jones PA. Epigenetic modifications as therapeutic targets. Nature Biotechnology. 28: 1069-78. PMID 20944599 DOI: 10.1038/Nbt.1678  0.448
2010 Qiu X, Hother C, Ralfkiær UM, Søgaard A, Lu Q, Workman CT, Liang G, Jones PA, Grønbæk K. Equitoxic doses of 5-azacytidine and 5-aza-2'deoxycytidine induce diverse immediate and overlapping heritable changes in the transcriptome. Plos One. 5. PMID 20927380 DOI: 10.1371/Journal.Pone.0012994  0.344
2010 Kelly TK, Miranda TB, Liang G, Berman BP, Lin JC, Tanay A, Jones PA. H2A.Z maintenance during mitosis reveals nucleosome shifting on mitotically silenced genes. Molecular Cell. 39: 901-11. PMID 20864037 DOI: 10.1016/J.Molcel.2010.08.026  0.446
2010 Yang X, Lay F, Han H, Jones PA. Targeting DNA methylation for epigenetic therapy. Trends in Pharmacological Sciences. 31: 536-46. PMID 20846732 DOI: 10.1016/J.Tips.2010.08.001  0.662
2010 Wolff EM, Chihara Y, Pan F, Weisenberger DJ, Siegmund KD, Sugano K, Kawashima K, Laird PW, Jones PA, Liang G. Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue. Cancer Research. 70: 8169-78. PMID 20841482 DOI: 10.1158/0008-5472.Can-10-1335  0.71
2010 De Carvalho DD, You JS, Jones PA. DNA methylation and cellular reprogramming. Trends in Cell Biology. 20: 609-17. PMID 20810283 DOI: 10.1016/J.Tcb.2010.08.003  0.502
2010 Chuang JC, Warner SL, Vollmer D, Vankayalapati H, Redkar S, Bearss DJ, Qiu X, Yoo CB, Jones PA. S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth. Molecular Cancer Therapeutics. 9: 1443-50. PMID 20442312 DOI: 10.1158/1535-7163.Mct-09-1048  0.845
2010 Wolff EM, Byun HM, Han HF, Sharma S, Nichols PW, Siegmund KD, Yang AS, Jones PA, Liang G. Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer. Plos Genetics. 6: e1000917. PMID 20421991 DOI: 10.1371/Journal.Pgen.1000917  0.761
2010 Miranda TB, Kelly TK, Bouazoune K, Jones PA. Methylation-sensitive single-molecule analysis of chromatin structure. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 21.17.1-16. PMID 20069538 DOI: 10.1002/0471142727.Mb2117S89  0.436
2010 Sharma S, Kelly TK, Jones PA. Epigenetics in cancer. Carcinogenesis. 31: 27-36. PMID 19752007 DOI: 10.1093/Carcin/Bgp220  0.641
2010 Treppendahl MB, Qiu X, Hother C, Andersen MK, Kjeldsen L, Jones P, Liang G, Gr∅nbæk K. Epigenetic Silencing of a Novel Candidate Tumor Suppressor “miR” Predicts Poor Prognosis In High-Risk MDS and AML. Blood. 116: 3629-3629. DOI: 10.1182/Blood.V116.21.3629.3629  0.472
2010 Cruz AT, Souza CF, Morais AS, Costa FF, Xander P, Melisso FM, Molognoni F, Liang G, Jones PA, Jasiulionis MG. Abstract 4892: Epigenetic reprogramming associated with melanocyte malignant transformation induced by sustained stress condition Cancer Research. 70: 4892-4892. DOI: 10.1158/1538-7445.Am10-4892  0.485
2010 Liang G, Wolff EM, Han HF, Byun H, Sharma S, Nichols P, Siegmund KD, Jones PA. Abstract 4801: Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer Cancer Research. 70: 4801-4801. DOI: 10.1158/1538-7445.Am10-4801  0.738
2009 Ricca TI, Liang G, Suenaga AP, Han SW, Jones PA, Jasiulionis MG. Tissue inhibitor of metalloproteinase 1 expression associated with gene demethylation confers anoikis resistance in early phases of melanocyte malignant transformation. Translational Oncology. 2: 329-40. PMID 19956395 DOI: 10.1593/Tlo.09220  0.388
2009 Jones PA, Liang G. Rethinking how DNA methylation patterns are maintained. Nature Reviews. Genetics. 10: 805-11. PMID 19789556 DOI: 10.1038/Nrg2651  0.502
2009 Friedman JM, Jones PA, Liang G. The tumor suppressor microRNA-101 becomes an epigenetic player by targeting the polycomb group protein EZH2 in cancer. Cell Cycle (Georgetown, Tex.). 8: 2313-4. PMID 19625769 DOI: 10.4161/Cc.8.15.9168  0.368
2009 Jeong S, Liang G, Sharma S, Lin JC, Choi SH, Han H, Yoo CB, Egger G, Yang AS, Jones PA. Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA. Molecular and Cellular Biology. 29: 5366-76. PMID 19620278 DOI: 10.1128/Mcb.00484-09  0.828
2009 Bouazoune K, Miranda TB, Jones PA, Kingston RE. Analysis of individual remodeled nucleosomes reveals decreased histone-DNA contacts created by hSWI/SNF. Nucleic Acids Research. 37: 5279-94. PMID 19567737 DOI: 10.1093/Nar/Gkp524  0.416
2009 Miranda TB, Cortez CC, Yoo CB, Liang G, Abe M, Kelly TK, Marquez VE, Jones PA. DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Molecular Cancer Therapeutics. 8: 1579-88. PMID 19509260 DOI: 10.1158/1535-7163.Mct-09-0013  0.847
2009 Aparicio A, North B, Barske L, Wang X, Bollati V, Weisenberger D, Yoo C, Tannir N, Horne E, Groshen S, Jones P, Yang A, Issa JP. LINE-1 methylation in plasma DNA as a biomarker of activity of DNA methylation inhibitors in patients with solid tumors. Epigenetics. 4: 176-84. PMID 19421002 DOI: 10.4161/Epi.4.3.8694  0.772
2009 Friedman JM, Liang G, Liu CC, Wolff EM, Tsai YC, Ye W, Zhou X, Jones PA. The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2. Cancer Research. 69: 2623-9. PMID 19258506 DOI: 10.1158/0008-5472.CAN-08-3114  0.614
2009 Youssef RF, Mitra AP, Bartsch G, Jones PA, Skinner DG, Cote RJ. Molecular targets and targeted therapies in bladder cancer management. World Journal of Urology. 27: 9-20. PMID 19039591 DOI: 10.1007/S00345-008-0357-X  0.346
2008 Yoo CB, Chuang JC, Byun HM, Egger G, Yang AS, Dubeau L, Long T, Laird PW, Marquez VE, Jones PA. Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice. Cancer Prevention Research (Philadelphia, Pa.). 1: 233-40. PMID 19138966 DOI: 10.1158/1940-6207.Capr-07-0008  0.807
2008 Yoo CB, Valente R, Congiatu C, Gavazza F, Angel A, Siddiqui MA, Jones PA, McGuigan C, Marquez VE. Activation of p16 gene silenced by DNA methylation in cancer cells by phosphoramidate derivatives of 2'-deoxyzebularine. Journal of Medicinal Chemistry. 51: 7593-601. PMID 19006382 DOI: 10.1021/Jm8005965  0.785
2008 Gal-Yam EN, Egger G, Iniguez L, Holster H, Einarsson S, Zhang X, Lin JC, Liang G, Jones PA, Tanay A. Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line. Proceedings of the National Academy of Sciences of the United States of America. 105: 12979-84. PMID 18753622 DOI: 10.1073/Pnas.0806437105  0.581
2008 Cortez CC, Jones PA. Chromatin, cancer and drug therapies. Mutation Research. 647: 44-51. PMID 18691602 DOI: 10.1016/J.Mrfmmm.2008.07.006  0.776
2008 Wolff EM, Liang G, Cortez CC, Tsai YC, Castelao JE, Cortessis VK, Tsao-Wei DD, Groshen S, Jones PA. RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. Cancer Research. 68: 6208-14. PMID 18676844 DOI: 10.1158/0008-5472.CAN-07-6616  0.808
2008 Weisenberger DJ, Trinh BN, Campan M, Sharma S, Long TI, Ananthnarayan S, Liang G, Esteva FJ, Hortobagyi GN, McCormick F, Jones PA, Laird PW. DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight. Nucleic Acids Research. 36: 4689-98. PMID 18628296 DOI: 10.1093/nar/gkn455  0.576
2008 van Rietschoten JG, Gal-Yam EN, Jeong S, Cortez CC, Verweij CL, Jones PA. Epigenetic regulation and nucleosome positioning in the human TATA-less IL-1 alpha promoter. Genes and Immunity. 9: 582-90. PMID 18615092 DOI: 10.1038/Gene.2008.53  0.718
2008 Morgan MK, Sheldon LS, Thomas KW, Egeghy PP, Croghan CW, Jones PA, Chuang JC, Wilson NK. Adult and children's exposure to 2,4-D from multiple sources and pathways. Journal of Exposure Science & Environmental Epidemiology. 18: 486-94. PMID 18167507 DOI: 10.1038/sj.jes.7500641  0.483
2008 Gal-Yam EN, Saito Y, Egger G, Jones PA. Cancer epigenetics: modifications, screening, and therapy. Annual Review of Medicine. 59: 267-80. PMID 17937590 DOI: 10.1146/Annurev.Med.59.061606.095816  0.48
2008 Hother C, Cortez C, Miranda T, Yoo C, Workman C, Jones PA, Grønbæk K. 47 Upregulation of the miR-515 cluster in the MCF7 breast cancer cell line by epigenetic therapy Apmis. 116: 437-437. DOI: 10.1111/J.1600-0463.2008.00Abs1165_54.X  0.705
2007 George B, Datar RH, Wu L, Cai J, Patten N, Beil SJ, Groshen S, Stein J, Skinner D, Jones PA, Cote RJ. p53 gene and protein status: the role of p53 alterations in predicting outcome in patients with bladder cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 25: 5352-8. PMID 18048815 DOI: 10.1200/Jco.2006.10.4125  0.329
2007 Grønbaek K, Hother C, Jones PA. Epigenetic changes in cancer. Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. 115: 1039-59. PMID 18042143 DOI: 10.1111/J.1600-0463.2007.Apm_636.Xml.X  0.562
2007 Lin JC, Jeong S, Liang G, Takai D, Fatemi M, Tsai YC, Egger G, Gal-Yam EN, Jones PA. Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island. Cancer Cell. 12: 432-44. PMID 17996647 DOI: 10.1016/J.Ccr.2007.10.014  0.554
2007 Miranda TB, Jones PA. DNA methylation: the nuts and bolts of repression. Journal of Cellular Physiology. 213: 384-90. PMID 17708532 DOI: 10.1002/Jcp.21224  0.548
2007 Yoo CB, Jeong S, Egger G, Liang G, Phiasivongsa P, Tang C, Redkar S, Jones PA. Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides. Cancer Research. 67: 6400-8. PMID 17616700 DOI: 10.1158/0008-5472.Can-07-0251  0.79
2007 Chuang JC, Jones PA. Epigenetics and microRNAs. Pediatric Research. 61: 24R-29R. PMID 17413852 DOI: 10.1203/Pdr.0B013E3180457684  0.638
2007 Jones PA, Baylin SB. The epigenomics of cancer. Cell. 128: 683-92. PMID 17320506 DOI: 10.1016/J.Cell.2007.01.029  0.42
2007 Morgan MK, Sheldon LS, Croghan CW, Jones PA, Chuang JC, Wilson NK. An observational study of 127 preschool children at their homes and daycare centers in Ohio: environmental pathways to cis- and trans-permethrin exposure. Environmental Research. 104: 266-74. PMID 17258193 DOI: 10.1016/j.envres.2006.11.011  0.482
2007 Egger G, Aparicio AM, Escobar SG, Jones PA. Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2'-deoxycytidine treatment. Cancer Research. 67: 346-53. PMID 17210717 DOI: 10.1158/0008-5472.Can-06-2845  0.505
2006 Gal-Yam EN, Jeong S, Tanay A, Egger G, Lee AS, Jones PA. Constitutive nucleosome depletion and ordered factor assembly at the GRP78 promoter revealed by single molecule footprinting. Plos Genetics. 2: e160. PMID 17002502 DOI: 10.1371/Journal.Pgen.0020160  0.321
2006 Jia L, Shen HC, Wantroba M, Khalid O, Liang G, Wang Q, Gentzschein E, Pinski JK, Stanczyk FZ, Jones PA, Coetzee GA. Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells. Molecular and Cellular Biology. 26: 7331-41. PMID 16980632 DOI: 10.1128/Mcb.00581-06  0.378
2006 Egger G, Jeong S, Escobar SG, Cortez CC, Li TW, Saito Y, Yoo CB, Jones PA, Liang G. Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival. Proceedings of the National Academy of Sciences of the United States of America. 103: 14080-5. PMID 16963560 DOI: 10.1073/Pnas.0604602103  0.846
2006 van Rietschoten JG, Verzijlbergen KF, Gringhuis SI, van der Pouw Kraan TC, Bayley JP, Wierenga EA, Jones PA, Kooter JM, Verweij CL. Differentially methylated alleles in a distinct region of the human interleukin-1alpha promoter are associated with allele-specific expression of IL-1alpha in CD4+ T cells. Blood. 108: 2143-9. PMID 16788102 DOI: 10.1182/Blood-2006-01-021147  0.388
2006 Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA, Jones PA. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell. 9: 435-43. PMID 16766263 DOI: 10.1016/J.Ccr.2006.04.020  0.626
2006 Yoo CB, Jones PA. Epigenetic therapy of cancer: past, present and future. Nature Reviews. Drug Discovery. 5: 37-50. PMID 16485345 DOI: 10.1038/Nrd1930  0.765
2006 Yoo CB, Jones PA. Erratum: Epigenetic therapy of cancer: past, present and future Nature Reviews Drug Discovery. 5: 170-170. DOI: 10.1038/Nrd1981  0.705
2005 Wolff EM, Liang G, Jones PA. Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer. Nature Clinical Practice. Urology. 2: 502-10. PMID 16474624 DOI: 10.1038/Ncpuro0318  0.663
2005 Marquez VE, Kelley JA, Agbaria R, Ben-Kasus T, Cheng JC, Yoo CB, Jones PA. Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy. Annals of the New York Academy of Sciences. 1058: 246-54. PMID 16394141 DOI: 10.1196/Annals.1359.037  0.786
2005 Jones PA, Martienssen R. A blueprint for a Human Epigenome Project: the AACR Human Epigenome Workshop. Cancer Research. 65: 11241-6. PMID 16357125 DOI: 10.1158/0008-5472.Can-05-3865  0.357
2005 Fatemi M, Pao MM, Jeong S, Gal-Yam EN, Egger G, Weisenberger DJ, Jones PA. Footprinting of mammalian promoters: use of a CpG DNA methyltransferase revealing nucleosome positions at a single molecule level. Nucleic Acids Research. 33: e176. PMID 16314307 DOI: 10.1093/Nar/Gni180  0.717
2005 Marquez VE, Barchi JJ, Kelley JA, Rao KV, Agbaria R, Ben-Kasus T, Cheng JC, Yoo CB, Jones PA. Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy. The magic of its chemistry and biology. Nucleosides, Nucleotides & Nucleic Acids. 24: 305-18. PMID 16247946 DOI: 10.1081/Ncn-200059765  0.783
2005 Friedrich MG, Chandrasoma S, Siegmund KD, Weisenberger DJ, Cheng JC, Toma MI, Huland H, Jones PA, Liang G. Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma. European Journal of Cancer (Oxford, England : 1990). 41: 2769-78. PMID 16242928 DOI: 10.1016/J.Ejca.2005.07.019  0.662
2005 Chuang JC, Yoo CB, Kwan JM, Li TW, Liang G, Yang AS, Jones PA. Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine. Molecular Cancer Therapeutics. 4: 1515-20. PMID 16227400 DOI: 10.1158/1535-7163.Mct-05-0172  0.843
2005 Jones PA. Overview of cancer epigenetics. Seminars in Hematology. 42: S3-8. PMID 16015502 DOI: 10.1053/J.Seminhematol.2005.05.001  0.519
2005 Takai N, Kawamata N, Walsh CS, Gery S, Desmond JC, Whittaker S, Said JW, Popoviciu LM, Jones PA, Miyakawa I, Koeffler HP. Discovery of epigenetically masked tumor suppressor genes in endometrial cancer. Molecular Cancer Research : McR. 3: 261-9. PMID 15886297 DOI: 10.1158/1541-7786.Mcr-04-0110  0.514
2005 Morgan MK, Sheldon LS, Croghan CW, Jones PA, Robertson GL, Chuang JC, Wilson NK, Lyu CW. Exposures of preschool children to chlorpyrifos and its degradation product 3,5,6-trichloro-2-pyridinol in their everyday environments. Journal of Exposure Analysis and Environmental Epidemiology. 15: 297-309. PMID 15367928 DOI: 10.1038/sj.jea.7500406  0.483
2004 Friedrich MG, Weisenberger DJ, Cheng JC, Chandrasoma S, Siegmund KD, Gonzalgo ML, Toma MI, Huland H, Yoo C, Tsai YC, Nichols PW, Bochner BH, Jones PA, Liang G. Detection of methylated apoptosis-associated genes in urine sediments of bladder cancer patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 7457-65. PMID 15569975 DOI: 10.1158/1078-0432.Ccr-04-0930  0.846
2004 Yoo CB, Cheng JC, Jones PA. Zebularine: a new drug for epigenetic therapy. Biochemical Society Transactions. 32: 910-2. PMID 15506921 DOI: 10.1042/Bst0320910  0.827
2004 Cheng JC, Yoo CB, Weisenberger DJ, Chuang J, Wozniak C, Liang G, Marquez VE, Greer S, Orntoft TF, Thykjaer T, Jones PA. Preferential response of cancer cells to zebularine. Cancer Cell. 6: 151-8. PMID 15324698 DOI: 10.1016/J.Ccr.2004.06.023  0.851
2004 Chatterjee SJ, George B, Goebell PJ, Alavi-Tafreshi M, Shi SR, Fung YK, Jones PA, Cordon-Cardo C, Datar RH, Cote RJ. Hyperphosphorylation of pRb: a mechanism for RB tumour suppressor pathway inactivation in bladder cancer. The Journal of Pathology. 203: 762-70. PMID 15221935 DOI: 10.1002/Path.1567  0.317
2004 Widschwendter M, Siegmund KD, Müller HM, Fiegl H, Marth C, Müller-Holzner E, Jones PA, Laird PW. Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen. Cancer Research. 64: 3807-13. PMID 15172987 DOI: 10.1158/0008-5472.CAN-03-3852  0.404
2004 Egger G, Liang G, Aparicio A, Jones PA. Epigenetics in human disease and prospects for epigenetic therapy. Nature. 429: 457-63. PMID 15164071 DOI: 10.1038/Nature02625  0.476
2004 Liang G, Lin JC, Wei V, Yoo C, Cheng JC, Nguyen CT, Weisenberger DJ, Egger G, Takai D, Gonzales FA, Jones PA. Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. Proceedings of the National Academy of Sciences of the United States of America. 101: 7357-62. PMID 15123803 DOI: 10.1073/Pnas.0401866101  0.818
2004 Weisenberger DJ, Velicescu M, Cheng JC, Gonzales FA, Liang G, Jones PA. Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation. Molecular Cancer Research : McR. 2: 62-72. PMID 14757847  0.654
2004 Cheng JC, Weisenberger DJ, Gonzales FA, Liang G, Xu GL, Hu YG, Marquez VE, Jones PA. Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells. Molecular and Cellular Biology. 24: 1270-8. PMID 14729971 DOI: 10.1128/Mcb.24.3.1270-1278.2004  0.699
2004 Takai D, Jones PA. Origins of bidirectional promoters: computational analyses of intergenic distance in the human genome. Molecular Biology and Evolution. 21: 463-7. PMID 14660682 DOI: 10.1093/Molbev/Msh040  0.355
2004 Friedrich M, Liang G, Siegmund K, Weisenberger D, Cheng J, Toma M, Jones P, Huland H. 212 Frequent methylation of apoptosis-associated genes in bladder cancer cell lines, tumour samples, and urine samples for diagnosis of bladder cancer European Urology Supplements. 3: 55. DOI: 10.1016/S1569-9056(04)90213-8  0.586
2004 Widschwendter M, Siegmund K, Mueller H, Fiegl H, Marth C, Mueller-Holzner E, Jones P, Laird P. P31 DNA methylation profiles in breast cancer — relation to hormone receptors and role in response to adjuvant endocrine treatment European Journal of Cancer Supplements. 2: 50. DOI: 10.1016/S1359-6349(04)90148-6  0.305
2004 Friedrich MG, Liang G, Toma MI, Weisenberger DJ, Cheng JC, Siegmund KD, Huland H, Jones PA. 743: Methylation of the E-Cadherin and the TIMP-3 Genes are Positive Prognostic Markers for Patients with Non-Muscle Invasive Bladder Carcinoma Journal of Urology. 171: 197-197. DOI: 10.1016/S0022-5347(18)37992-8  0.576
2003 Matsukura S, Jones PA, Takai D. Establishment of conditional vectors for hairpin siRNA knockdowns. Nucleic Acids Research. 31: e77. PMID 12888529 DOI: 10.1093/Nar/Gng077  0.37
2003 Hsieh CL, Jones PA. Meddling with methylation. Nature Cell Biology. 5: 502-4. PMID 12776125 DOI: 10.1038/Ncb0603-502  0.528
2003 Jones PA. Epigenetics in carcinogenesis and cancer prevention. Annals of the New York Academy of Sciences. 983: 213-9. PMID 12724226 DOI: 10.1111/J.1749-6632.2003.Tb05976.X  0.382
2003 Jones PA. An epigenetic approach for finding tumor suppressors. Cell Cycle (Georgetown, Tex.). 2: 25-6. PMID 12695681 DOI: 10.4161/Cc.2.1.251  0.333
2003 Cheng JC, Matsen CB, Gonzales FA, Ye W, Greer S, Marquez VE, Jones PA, Selker EU. Inhibition of DNA methylation and reactivation of silenced genes by zebularine. Journal of the National Cancer Institute. 95: 399-409. PMID 12618505 DOI: 10.1093/Jnci/95.5.399  0.686
2002 Nguyen CT, Weisenberger DJ, Velicescu M, Gonzales FA, Lin JC, Liang G, Jones PA. Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine. Cancer Research. 62: 6456-61. PMID 12438235  0.628
2002 Weisenberger DJ, Velicescu M, Preciado-Lopez MA, Gonzales FA, Tsai YC, Liang G, Jones PA. Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells. Gene. 298: 91-9. PMID 12406579 DOI: 10.1016/S0378-1119(02)00976-9  0.436
2002 Daskalakis M, Nguyen TT, Nguyen C, Guldberg P, Köhler G, Wijermans P, Jones PA, Lübbert M. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment. Blood. 100: 2957-64. PMID 12351408 DOI: 10.1182/Blood.V100.8.2957  0.624
2002 Widschwendter M, Jones PA. DNA methylation and breast carcinogenesis. Oncogene. 21: 5462-82. PMID 12154408 DOI: 10.1038/Sj.Onc.1205606  0.53
2002 Jones PA. DNA methylation and cancer. Oncogene. 21: 5358-60. PMID 12154398 DOI: 10.1038/Sj.Onc.1205597  0.588
2002 Liang G, Gonzalgo ML, Salem C, Jones PA. Identification of DNA methylation differences during tumorigenesis by methylation-sensitive arbitrarily primed polymerase chain reaction. Methods (San Diego, Calif.). 27: 150-5. PMID 12095274 DOI: 10.1016/S1046-2023(02)00068-3  0.71
2002 Gonzalgo ML, Jones PA. Quantitative methylation analysis using methylation-sensitive single-nucleotide primer extension (Ms-SNuPE). Methods (San Diego, Calif.). 27: 128-33. PMID 12095270 DOI: 10.1016/S1046-2023(02)00064-6  0.671
2002 Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nature Reviews. Genetics. 3: 415-28. PMID 12042769 DOI: 10.1038/Nrg816  0.56
2002 Velicescu M, Weisenberger DJ, Gonzales FA, Tsai YC, Nguyen CT, Jones PA. Cell division is required for de novo methylation of CpG islands in bladder cancer cells. Cancer Research. 62: 2378-84. PMID 11956100  0.683
2002 Takai D, Jones PA. Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proceedings of the National Academy of Sciences of the United States of America. 99: 3740-5. PMID 11891299 DOI: 10.1073/Pnas.052410099  0.416
2002 Liang G, Gonzales FA, Jones PA, Orntoft TF, Thykjaer T. Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2'-deoxycytidine. Cancer Research. 62: 961-6. PMID 11861364  0.409
2002 Widschwendter M, Jones PA. The potential prognostic, predictive, and therapeutic values of DNA methylation in cancer. Commentary re: J. Kwong et al., Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. Clin. Cancer Res., 8: 131-137, 2002, and H-Z. Zou et al., Detection of aberrant p16 methylation in the serum of colorectal cancer patients. Clin. Cancer Res., 8: 188-191, 2002. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 17-21. PMID 11801535  0.323
2002 Liang G, Chan MF, Tomigahara Y, Tsai YC, Gonzales FA, Li E, Laird PW, Jones PA. Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Molecular and Cellular Biology. 22: 480-91. PMID 11756544 DOI: 10.1128/Mcb.22.2.480-491.2002  0.721
2001 Takai D, Gonzales FA, Tsai YC, Thayer MJ, Jones PA. Large scale mapping of methylcytosines in CTCF-binding sites in the human H19 promoter and aberrant hypomethylation in human bladder cancer. Human Molecular Genetics. 10: 2619-26. PMID 11726548 DOI: 10.1093/Hmg/10.23.2619  0.431
2001 Nguyen CT, Gonzales FA, Jones PA. Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation. Nucleic Acids Research. 29: 4598-606. PMID 11713309 DOI: 10.1093/Nar/29.22.4598  0.718
2001 Chan MF, van Amerongen R, Nijjar T, Cuppen E, Jones PA, Laird PW. Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells. Molecular and Cellular Biology. 21: 7587-600. PMID 11604495 DOI: 10.1128/Mcb.21.22.7587-7600.2001  0.679
2001 Nguyen C, Liang G, Nguyen TT, Tsao-Wei D, Groshen S, Lübbert M, Zhou JH, Benedict WF, Jones PA. Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells. Journal of the National Cancer Institute. 93: 1465-72. PMID 11584062 DOI: 10.1093/Jnci/93.19.1465  0.73
2001 Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science (New York, N.Y.). 293: 1068-70. PMID 11498573 DOI: 10.1126/Science.1063852  0.539
2001 Markl ID, Cheng J, Liang G, Shibata D, Laird PW, Jones PA. Global and gene-specific epigenetic patterns in human bladder cancer genomes are relatively stable in vivo and in vitro over time. Cancer Research. 61: 5875-84. PMID 11479229  0.839
2001 Xiong Z, Wu AH, Bender CM, Tsao JL, Blake C, Shibata D, Jones PA, Yu MC, Ross RK, Laird PW. Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomas. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 10: 799-803. PMID 11440966  0.413
2001 Pao MM, Tsutsumi M, Liang G, Uzvolgyi E, Gonzales FA, Jones PA. The endothelin receptor B (EDNRB) promoter displays heterogeneous, site specific methylation patterns in normal and tumor cells. Human Molecular Genetics. 10: 903-10. PMID 11309363 DOI: 10.1093/Hmg/10.9.903  0.711
2001 Jones PA. Cancer. Death and methylation. Nature. 409: 141, 143-4. PMID 11196623 DOI: 10.1038/35051677  0.403
2000 Liang G, Robertson KD, Talmadge C, Sumegi J, Jones PA. The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells. Cancer Research. 60: 4907-12. PMID 10987305  0.344
2000 Tsao JL, Yatabe Y, Markl ID, Hajyan K, Jones PA, Shibata D. Bladder cancer genotype stability during clinical progression. Genes, Chromosomes & Cancer. 29: 26-32. PMID 10918390 DOI: 10.1002/1098-2264(2000)9999:9999<::Aid-Gcc1002>3.0.Co;2-X  0.78
2000 Salem CE, Markl ID, Bender CM, Gonzales FA, Jones PA, Liang G. PAX6 methylation and ectopic expression in human tumor cells. International Journal of Cancer. Journal International Du Cancer. 87: 179-85. PMID 10861471 DOI: 10.1002/1097-0215(20000715)87:2<179::Aid-Ijc4>3.0.Co;2-X  0.846
2000 Salem C, Liang G, Tsai YC, Coulter J, Knowles MA, Feng AC, Groshen S, Nichols PW, Jones PA. Progressive increases in de novo methylation of CpG islands in bladder cancer. Cancer Research. 60: 2473-6. PMID 10811126  0.435
2000 Chan MF, Liang G, Jones PA. Relationship between transcription and DNA methylation. Current Topics in Microbiology and Immunology. 249: 75-86. PMID 10802939  0.665
2000 Nguyen TT, Nguyen CT, Gonzales FA, Nichols PW, Yu MC, Jones PA. Analysis of cyclin-dependent kinase inhibitor expression and methylation patterns in human prostate cancers. The Prostate. 43: 233-42. PMID 10797499 DOI: 10.1002/(Sici)1097-0045(20000515)43:3<233::Aid-Pros10>3.0.Co;2-S  0.604
2000 Nguyen TT, Mohrbacher AF, Tsai YC, Groffen J, Heisterkamp N, Nichols PW, Yu MC, Lübbert M, Jones PA. Quantitative measure of c-abl and p15 methylation in chronic myelogenous leukemia: biological implications. Blood. 95: 2990-2. PMID 10779450 DOI: 10.1182/Blood.V95.9.2990.009K08_2990_2992  0.436
2000 Robertson KD, Keyomarsi K, Gonzales FA, Velicescu M, Jones PA. Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells. Nucleic Acids Research. 28: 2108-13. PMID 10773079 DOI: 10.1093/Nar/28.10.2108  0.497
2000 Pao MM, Liang G, Tsai YC, Xiong Z, Laird PW, Jones PA. DNA methylator and mismatch repair phenotypes are not mutually exclusive in colorectal cancer cell lines. Oncogene. 19: 943-52. PMID 10702803 DOI: 10.1038/Sj.Onc.1203414  0.765
2000 Robertson KD, Jones PA. DNA methylation: past, present and future directions. Carcinogenesis. 21: 461-7. PMID 10688866 DOI: 10.1093/Carcin/21.3.461  0.559
1999 Jones PA. DNA methylation in development of bladder cancer. Advances in Experimental Medicine and Biology. 462: 419-23. PMID 10599444 DOI: 10.1007/978-1-4615-4737-2_32  0.48
1999 Bender CM, Gonzalgo ML, Gonzales FA, Nguyen CT, Robertson KD, Jones PA. Roles of cell division and gene transcription in the methylation of CpG islands. Molecular and Cellular Biology. 19: 6690-8. PMID 10490608 DOI: 10.1128/Mcb.19.10.6690  0.677
1999 Robertson KD, Jones PA. Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus. Oncogene. 18: 3810-20. PMID 10445844 DOI: 10.1038/Sj.Onc.1202737  0.354
1999 Robertson KD, Uzvolgyi E, Liang G, Talmadge C, Sumegi J, Gonzales FA, Jones PA. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Research. 27: 2291-8. PMID 10325416 DOI: 10.1093/Nar/27.11.2291  0.511
1999 Jones PA, Ross RK. Prevention of bladder cancer. The New England Journal of Medicine. 340: 1424-6. PMID 10228196 DOI: 10.1056/Nejm199905063401810  0.323
1999 Jones PA. The DNA methylation paradox. Trends in Genetics : Tig. 15: 34-7. PMID 10087932 DOI: 10.1016/S0168-9525(98)01636-9  0.518
1999 Jones PA, Laird PW. Cancer epigenetics comes of age. Nature Genetics. 21: 163-7. PMID 9988266 DOI: 10.1038/5947  0.552
1999 Salem CE, Liang G, Skinner DG, Jones PA. Dna Methylation As A Possible Predictor Of Bladder Cancer Progression The Journal of Urology. 116. DOI: 10.1097/00005392-199904010-00467  0.535
1998 Tsutsumi M, Tsai YC, Gonzalgo ML, Nichols PW, Jones PA. Early acquisition of homozygous deletions of p16/p19 during squamous cell carcinogenesis and genetic mosaicism in bladder cancer. Oncogene. 17: 3021-7. PMID 9881704 DOI: 10.1038/Sj.Onc.1202228  0.337
1998 Markl ID, Jones PA. Presence and location of TP53 mutation determines pattern of CDKN2A/ARF pathway inactivation in bladder cancer. Cancer Research. 58: 5348-53. PMID 9850064  0.799
1998 Liang G, Salem CE, Yu MC, Nguyen HD, Gonzales FA, Nguyen TT, Nichols PW, Jones PA. DNA methylation differences associated with tumor tissues identified by genome scanning analysis. Genomics. 53: 260-8. PMID 9799591 DOI: 10.1006/Geno.1998.5502  0.593
1998 Robertson KD, Jones PA. The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Molecular and Cellular Biology. 18: 6457-73. PMID 9774662 DOI: 10.1128/Mcb.18.11.6457  0.5
1998 Stein JP, Ginsberg DA, Grossfeld GD, Chatterjee SJ, Esrig D, Dickinson MG, Groshen S, Taylor CR, Jones PA, Skinner DG, Cote RJ. Effect of p21WAF1/CIP1 expression on tumor progression in bladder cancer. Journal of the National Cancer Institute. 90: 1072-9. PMID 9672255 DOI: 10.1093/Jnci/90.14.1072  0.369
1998 Schmutte C, Jones PA. Involvement of DNA methylation in human carcinogenesis. Biological Chemistry. 379: 377-88. PMID 9628328  0.442
1998 Jones PA, Gonzalgo ML, Tsutsumi M, Bender CM. DNA methylation in bladder cancer. European Urology. 33: 7-8. PMID 9615197 DOI: 10.1159/000052251  0.534
1998 Hatano N, Eversole-Cire P, Ferguson-Smith AC, Jones PA, Surani MA, Sasaki H. Enhancer-dependent, locus-wide regulation of the imprinted mouse insulin-like growth factor II gene. Journal of Biochemistry. 123: 984-91. PMID 9562635 DOI: 10.1093/Oxfordjournals.Jbchem.A022034  0.311
1998 Bender CM, Zingg JM, Jones PA. DNA methylation as a target for drug design. Pharmaceutical Research. 15: 175-87. PMID 9523301 DOI: 10.1023/A:1011946030404  0.569
1998 Gonzalgo ML, Hayashida T, Bender CM, Pao MM, Tsai YC, Gonzales FA, Nguyen HD, Nguyen TT, Jones PA. The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines. Cancer Research. 58: 1245-52. PMID 9515812  0.745
1998 Bender CM, Pao MM, Jones PA. Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Research. 58: 95-101. PMID 9426064  0.692
1997 Hayashida T, Eversole-Cire P, Jones PA, Sasaki H. Imprinted genes are up-regulated by growth arrest in embryonic fibroblasts. Journal of Biochemistry. 122: 901-3. PMID 9443803 DOI: 10.1093/Oxfordjournals.Jbchem.A021850  0.341
1997 Robertson KD, Jones PA. Dynamic interrelationships between DNA replication, methylation, and repair. American Journal of Human Genetics. 61: 1220-4. PMID 9399916 DOI: 10.1086/301658  0.429
1997 Gonzalgo ML, Bender CM, You EH, Glendening JM, Flores JF, Walker GJ, Hayward NK, Jones PA, Fountain JW. Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors. Cancer Research. 57: 5336-47. PMID 9393758  0.457
1997 Kissil JL, Feinstein E, Cohen O, Jones PA, Tsai YC, Knowles MA, Eydmann ME, Kimchi A. DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene. Oncogene. 15: 403-7. PMID 9242376 DOI: 10.1038/Sj.Onc.1201172  0.37
1997 Gonzalgo ML, Jones PA. Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE). Nucleic Acids Research. 25: 2529-31. PMID 9171109 DOI: 10.1093/Nar/25.12.2529  0.494
1997 Zingg JM, Jones PA. Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis. 18: 869-82. PMID 9163670  0.357
1997 Jones PA, Gonzalgo ML. Altered DNA methylation and genome instability: a new pathway to cancer? Proceedings of the National Academy of Sciences of the United States of America. 94: 2103-5. PMID 9122155 DOI: 10.1073/Pnas.94.6.2103  0.569
1997 Gonzalgo ML, Jones PA. Mutagenic and epigenetic effects of DNA methylation. Mutation Research. 386: 107-18. PMID 9113112 DOI: 10.1016/S1383-5742(96)00047-6  0.579
1997 Gonzalgo ML, Liang G, Spruck CH, Zingg JM, Rideout WM, Jones PA. Identification and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR. Cancer Research. 57: 594-9. PMID 9044832  0.446
1997 Cote RJ, Esrig D, Groshen S, Jones PA, Skinner DG. p53 and treatment of bladder cancer. Nature. 385: 123-5. PMID 8990112 DOI: 10.1038/385123B0  0.325
1996 Simoneau AR, Spruck CH, Gonzalez-Zulueta M, Gonzalgo ML, Chan MF, Tsai YC, Dean M, Steven K, Horn T, Jones PA. Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations. Cancer Research. 56: 5039-43. PMID 8895761  0.559
1996 Zingg JM, Shen JC, Yang AS, Rapoport H, Jones PA. Methylation inhibitors can increase the rate of cytosine deamination by (cytosine-5)-DNA methyltransferase. Nucleic Acids Research. 24: 3267-75. PMID 8774911 DOI: 10.1093/Nar/24.16.3267  0.404
1996 Yang AS, Gonzalgo ML, Zingg JM, Millar RP, Buckley JD, Jones PA. The rate of CpG mutation in Alu repetitive elements within the p53 tumor suppressor gene in the primate germline Journal of Molecular Biology. 258: 240-250. PMID 8627622 DOI: 10.1006/Jmbi.1996.0246  0.332
1996 Shen JC, Zingg JM, Yang AS, Schmutte C, Jones PA. A mutant HpaII methyltransferase functions as a mutator enzyme. Nucleic Acids Research. 23: 4275-82. PMID 7501446 DOI: 10.1093/Nar/23.21.4275  0.322
1996 Yang AS, Jones PA, Shibata A. The Mutational Burden of 5-Methylcytosine Cold Spring Harbor Monograph Archive. 32: 77-94. DOI: 10.1101/087969490.32.77  0.345
1995 Yang AS, Shen JC, Zingg JM, Mi S, Jones PA. HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair. Nucleic Acids Research. 23: 1380-7. PMID 7753629 DOI: 10.1093/Nar/23.8.1380  0.411
1995 Tsai YC, Simoneau AR, Spruck CHI, Nichols PW, Steven K, Buckley JD, Jones PA. Mosaicism in Human Epithelium: Macroscopic Monoclonal Patches Cover the Urothelium The Journal of Urology. 153: 1697-1700. PMID 7715013 DOI: 10.1016/S0022-5347(01)67507-4  0.327
1995 Gonzalez-zulueta M, Shibata A, Ohneseit PF, Spruck CH, Busch C, Shamaa M, Elbaz M, Nichols PW, Gonzalgo ML, Malmström PU, Jones PA. High Frequency of Chromosome 9p Allelic Loss and CDKN2 Tumor Suppressor Gene Alterations in Squamous Cell Carcinoma of the Bladder Journal of the National Cancer Institute. 87: 1383-1393. PMID 7658499 DOI: 10.1093/Jnci/87.18.1383  0.332
1995 Padia Y, Ariatti M, Jones P. 5-Methylcytosine and 5-Azacytosine Containing 25Mer Duplexes: Synthesis and Investigation of their Interaction with HeLa Nuclear Protein Extracts Nucleosides, Nucleotides and Nucleic Acids. 14: 1091-1092. DOI: 10.1080/15257779508012541  0.478
1994 Magewu AN, Jones PA. Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer. Molecular and Cellular Biology. 14: 4225-32. PMID 8196660 DOI: 10.1128/Mcb.14.6.4225  0.502
1994 Shen Jc, Rideout WM, Jones PA. The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA Nucleic Acids Research. 22: 972-976. PMID 8152929 DOI: 10.1093/Nar/22.6.972  0.354
1994 Rideout WM, Eversole-Cire P, Spruck CH, Hustad CM, Coetzee GA, Gonzales FA, Jones PA. Progressive increases in the methylation status and heterochromatinization of the myoD CpG island during oncogenic transformation Molecular and Cellular Biology. 14: 6143-6152. PMID 8065347 DOI: 10.1128/Mcb.14.9.6143  0.538
1994 Shibata A, Ohneseit PF, Tsai YC, Spruck CH, Nichols PW, Chiang HS, Lai MK, Jones PA. Mutational spectrum in the p53 gene in bladder tumors from the endemic area of black foot disease in Taiwan. Carcinogenesis. 15: 1085-7. PMID 8020137 DOI: 10.1093/Carcin/15.6.1085  0.383
1994 Schmutte C, Rideout WM, Shen JC, Jones PA. Mutagenicity of nitric oxide is not caused by deamination of cytosine or 5-methylcytosine in double-stranded DNA Carcinogenesis. 15: 2899-2903. PMID 8001253 DOI: 10.1093/Carcin/15.12.2899  0.413
1994 Esrig D, Elmajian D, Groshen S, Freeman JA, Stein JP, Chen SC, Nichols PW, Skinner DG, Jones PA, Cote RJ. Accumulation of nuclear p53 and tumor progression in bladder cancer. The New England Journal of Medicine. 331: 1259-64. PMID 7935683 DOI: 10.1056/Nejm199411103311903  0.355
1993 Spruck CH, Rideout WM, Jones PA. DNA methylation and cancer Exs. 64: 487-509. PMID 8418957 DOI: 10.1007/978-3-0348-9118-9_22  0.534
1993 Chen J, Maxson R, Jones PA. Direct induction of DNA hypermethylation in sea urchin embryos by microinjection of 5-methyl dCTP stimulates early histone gene expression and leads to developmental arrest. Developmental Biology. 155: 75-86. PMID 8416846 DOI: 10.1006/Dbio.1993.1008  0.544
1993 Eversole-Cire P, Ferguson-Smith AC, Sasaki H, Brown KD, Cattanach BM, Gonzales FA, Surani MA, Jones PA. Activation of an Imprinted Igf 2 Gene in Mouse Somatic Cell Cultures Molecular and Cellular Biology. 13: 4928-4938. PMID 8336727 DOI: 10.1128/mcb.13.8.4928-4938.1993  0.452
1993 Surani MA, Sasaki H, Ferguson-Smith AC, Allen ND, Barton SC, Jones PA, Reik W. The inheritance of germline-specific epigenetic modifications during development. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 339: 165-72. PMID 8097048 DOI: 10.1098/Rstb.1993.0013  0.438
1992 Jones PA, Rideout WM, Shen J‐, Spruck CH, Tsai YC. Methylation, mutation and cancer Bioessays. 14: 33-36. PMID 1546979 DOI: 10.1002/Bies.950140107  0.509
1992 Shen JC, Rideout WM, Jones PA. High frequency mutagenesis by a DNA methyltransferase Cell. 71: 1073-1080. PMID 1473145 DOI: 10.1016/S0092-8674(05)80057-1  0.381
1992 Shen Jc, Creighton S, Jones PA, Goodman MF. A comparison of the fidelity of copying 5-methylcytosine and cytosine at a difined DNA template site Nucleic Acids Research. 20: 5119-5125. PMID 1383939 DOI: 10.1093/Nar/20.19.5119  0.32
1992 Sasaki H, Jones PA, Chaillet JR, Ferguson-Smith AC, Barton SC, Reik W, Surani MA. Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene. Genes & Development. 6: 1843-56. PMID 1383088 DOI: 10.1101/Gad.6.10.1843  0.369
1992 Boukamp P, Chen J, Gonzales F, Jones PA, Fusenig NE. Progressive stages of "transdifferentiation" from epidermal to mesenchymal phenotype induced by MyoD1 transfection, 5-aza-2'-deoxycytidine treatment, and selection for reduced cell attachment in the human keratinocyte line HaCaT. The Journal of Cell Biology. 116: 1257-71. PMID 1371288 DOI: 10.1083/Jcb.116.5.1257  0.312
1992 Fearon ER, Jones PA. Progressing toward a molecular description of colorectal cancer development. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 6: 2783-90. PMID 1321771 DOI: 10.1096/Fasebj.6.10.1321771  0.379
1991 Sidransky D, Eschenbach AV, Tsai YC, Jones P, Summerhayes I, Marshall F, Paul M, Green P, Hamilton SR, Frost P, Vogelstein B. Identification of p53 gene mutations in bladder cancers and urine samples Science. 252: 706-709. PMID 2024123 DOI: 10.1126/Science.2024123  0.369
1991 Hustad CM, Jones PA. Effect of myogenic determination on tumorigenicity of chemically transformed 10T1/2 cells. Molecular Carcinogenesis. 4: 153-61. PMID 1710465 DOI: 10.1002/Mc.2940040211  0.319
1991 Lerner S, Tsai Y, Jones P. Genetic aspects of bladder cancer progression World Journal of Urology. 9. DOI: 10.1007/Bf00184036  0.313
1990 Chandler LA, Jones PA. Hypomethylation of DNA in the regulation of gene expression. Developmental Biology (New York, N.Y. : 1985). 5: 335-49. PMID 2481475 DOI: 10.1007/978-1-4615-6817-9_12  0.466
1990 Jones PA, Buckley JD. The role of DNA methylation in cancer. Advances in Cancer Research. 54: 1-23. PMID 2404377 DOI: 10.1016/S0065-230X(08)60806-4  0.523
1990 Jones PA, Wolkowicz MJ, Rideout WM, Gonzales FA, Marziasz CM, Coetzee GA, Tapscott SJ. De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines Proceedings of the National Academy of Sciences of the United States of America. 87: 6117-6121. PMID 2385586 DOI: 10.1073/Pnas.87.16.6117  0.505
1990 Hiti AL, Rideout WM, Laug WE, Jones PA. Plasminogen activator regulation by transforming growth factor-β in normal and neoplastic human urothelium Cancer Communications. 2: 123-128. PMID 2114167 DOI: 10.3727/095535490820874632  0.312
1990 Jones PA, Wolkowicz MJ, Harrington MA, Gonzales F. Methylation and expression of the Myo D1 determination gene. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 326: 277-84. PMID 1968664 DOI: 10.1098/Rstb.1990.0011  0.441
1990 Rideout WM, Coetzee GA, Olumi AF, Jones PA. 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes Science. 249: 1288-1290. PMID 1697983 DOI: 10.1126/Science.1697983  0.431
1989 Hiti AL, Bogenmann E, Gonzales F, Jones PA. Expression of the MyoD1 muscle determination gene defines differentiation capability but not tumorigenicity of human rhabdomyosarcomas. Molecular and Cellular Biology. 9: 4722-30. PMID 2601695 DOI: 10.1128/Mcb.9.11.4722  0.36
1989 Michalowsky LA, Jones PA. Gene structure and transcription in mouse cells with extensively demethylated DNA. Molecular and Cellular Biology. 9: 885-92. PMID 2471061 DOI: 10.1128/Mcb.9.3.885  0.524
1989 Michalowsky LA, Jones PA. DNA methylation and differentiation. Environmental Health Perspectives. 80: 189-97. PMID 2466640 DOI: 10.1289/ehp.8980189  0.457
1988 Harrington MA, Jones PA. Mesodermal determination genes: evidence from DNA methylation studies Bioessays. 8: 100-103. PMID 3288193 DOI: 10.1002/Bies.950080403  0.414
1988 Harrington MA, Jones PA, Imagawa M, Karin M. Cytosine methylation does not affect binding of transcription factor Sp1 Proceedings of the National Academy of Sciences of the United States of America. 85: 2066-2070. PMID 3281160 DOI: 10.1073/Pnas.85.7.2066  0.44
1988 Harrington MA, Gonzales F, Jones PA. Effect of cellular determination on oncogenic transformation by chemicals and oncogenes Molecular and Cellular Biology. 8: 4322-4327. PMID 2460742 DOI: 10.1128/Mcb.8.10.4322  0.329
1987 Michalowsky LA, Jones PA. Differential nuclear protein binding to 5-azacytosine-containing DNA as a potential mechanism for 5-aza-2'-deoxycytidine resistance. Molecular and Cellular Biology. 7: 3076-83. PMID 2444874 DOI: 10.1128/MCB.7.9.3076  0.305
1987 Chandler LA, Ghazi H, Jones PA, Boukamp P, Fusenig NE. Allele-specific methylation of the human c-Ha-ras-1 gene. Cell. 50: 711-7. PMID 2441871 DOI: 10.1016/0092-8674(87)90329-1  0.438
1986 Kautiainen TL, Jones PA. Effects of DNA binding proteins on DNA methylation in vitro. Biochemistry. 24: 1193-6. PMID 4096900 DOI: 10.1021/Bi00326A021  0.511
1986 Kautiainen TL, Jones PA. DNA methylation in mammalian nuclei. Biochemistry. 24: 5575-81. PMID 4074714 DOI: 10.1021/Bi00341A043  0.505
1986 Terranova VP, Hic S, Diflorio RM, Lyall RM, Jones PA. Tumor cell metastasis. Critical Reviews in Oncology Hematology. 5: 87-114. PMID 3521925 DOI: 10.1016/S1040-8428(86)80022-1  0.302
1986 Nyce J, Liu L, Jones PA. Variable effects of DNA-synthesis inhibitors upon DNA methylation in mammalian cells. Nucleic Acids Research. 14: 4353-67. PMID 3086840 DOI: 10.1093/Nar/14.10.4353  0.473
1985 Jones PA. Altering gene expression with 5-azacytidine. Cell. 40: 485-6. PMID 2578884 DOI: 10.1016/0092-8674(85)90192-8  0.309
1985 Jones PA. Effects of 5-azacytidine and its 2'-deoxyderivative on cell differentiation and DNA methylation. Pharmacology & Therapeutics. 28: 17-27. PMID 2414786 DOI: 10.1016/0163-7258(85)90080-4  0.412
1984 Flatau E, Gonzales FA, Michalowsky LA, Jones PA. DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells. Molecular and Cellular Biology. 4: 2098-102. PMID 6209556 DOI: 10.1128/Mcb.4.10.2098  0.409
1984 Taylor SM, Constantinides PA, Jones PA. 5-Azacytidine, DNA methylation, and differentiation. Current Topics in Microbiology and Immunology. 108: 115-27. PMID 6201321 DOI: 10.1007/978-3-642-69370-0_8  0.398
1984 Riggs AD, Jones PA. 5-methylcytosine, gene regulation, and cancer. Advances in Cancer Research. 40: 1-30. PMID 6197868 DOI: 10.1016/S0065-230X(08)60678-8  0.477
1984 Wilson VL, Jones PA. Chemical carcinogen-mediated decreases in DNA 5-methylcytosine content of BALB/3T3 cells. Carcinogenesis. 5: 1027-31. PMID 6086166 DOI: 10.1093/carcin/5.8.1027  0.366
1983 Wilson VL, Jones PA. DNA methylation decreases in aging but not in immortal cells. Science (New York, N.Y.). 220: 1055-7. PMID 6844925 DOI: 10.1126/Science.6844925  0.468
1983 Wilson VL, Jones PA. Inhibition of DNA methylation by chemical carcinogens in vitro. Cell. 32: 239-46. PMID 6825170 DOI: 10.1016/0092-8674(83)90514-7  0.481
1983 Jones PA, Taylor SM, Wilson V. DNA modification, differentiation, and transformation Journal of Experimental Zoology. 228: 287-295. PMID 6198436 DOI: 10.1002/Jez.1402280212  0.549
1983 Jones PA, Taylor SM, Wilson VL. Inhibition of DNA methylation by 5-azacytidine. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer. 84: 202-11. PMID 6189159 DOI: 10.1007/978-3-642-81947-6_15  0.533
1982 Taylor SM, Jones PA. Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA Journal of Molecular Biology. 162: 679-692. PMID 6187927 DOI: 10.1016/0022-2836(82)90395-3  0.452
1982 Taylor SM, Jones PA. Changes in phenotypic expression in embryonic and adult cells treated with 5-azacytidine Journal of Cellular Physiology. 111: 187-194. PMID 6177706 DOI: 10.1002/Jcp.1041110210  0.332
1981 Jones PA, Taylor SM. Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells Nucleic Acids Research. 9: 2933-2947. PMID 6169003 DOI: 10.1093/Nar/9.12.2933  0.457
1980 Jones PA, Taylor SM. Cellular differentiation, cytidine analogs and DNA methylation Cell. 20: 85-93. PMID 6156004 DOI: 10.1016/0092-8674(80)90237-8  0.483
1979 Taylor SM, Jones PA. Multiple new phenotypes induced in 10T 1 2 and 3T3 cells treated with 5-azacytidine Cell. 17: 771-779. PMID 90553 DOI: 10.1016/0092-8674(79)90317-9  0.311
1976 Jones PA, Laug WE, Benedict WF. Fibrinolytic activity in a human fibrosarcoma cell line and evidence for the induction of plasminogen activator secretion during tumor formation. Cell. 6: 245-52. PMID 1182804 DOI: 10.1016/0092-8674(75)90015-X  0.314
1975 Laug WE, Jones PA, Benedict WF. Relationship between fibrinolysis of cultured cells and malignancy. Journal of the National Cancer Institute. 54: 173-9. PMID 123008 DOI: 10.1093/Jnci/54.1.173  0.309
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