Year |
Citation |
Score |
2023 |
Cook MA, Pallant D, Ejim L, Sutherland AD, Wang X, Johnson JW, McCusker S, Chen X, George M, Chou S, Koteva K, Wang W, Hobson C, Hackenberger D, Waglechner N, ... ... Wright GD, et al. Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory. Journal of Industrial Microbiology & Biotechnology. PMID 38052426 DOI: 10.1093/jimb/kuad042 |
0.555 |
|
2023 |
Schaenzer AJ, Rodriguez Hernandez A, Tsai K, Hobson C, Fujimori DG, Wright GD. Angucyclinones rescue PhLOPS antibiotic activity by inhibiting Cfr-dependent antibiotic resistance. Mbio. 14: e0179123. PMID 38014974 DOI: 10.1128/mbio.01791-23 |
0.721 |
|
2023 |
Bordeleau E, Stogios PJ, Evdokimova E, Koteva K, Savchenko A, Wright GD. Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance. Nature Chemical Biology. 20: 234-242. PMID 37973888 DOI: 10.1038/s41589-023-01483-3 |
0.395 |
|
2023 |
Gómez-Arrebola C, Hernandez SB, Culp EJ, Wright GD, Solano C, Cava F, Lasa I. susceptibility to complestatin and corbomycin depends on the VraSR two-component system. Microbiology Spectrum. 11: e0037023. PMID 37646518 DOI: 10.1128/spectrum.00370-23 |
0.33 |
|
2023 |
Koteva K, Xu M, Wang W, Fiebig-Comyn AA, Cook MA, Coombes BK, Wright GD. Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant . Journal of Medicinal Chemistry. PMID 37315221 DOI: 10.1021/acs.jmedchem.3c00633 |
0.325 |
|
2022 |
Surette MD, Waglechner N, Koteva K, Wright GD. HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics. Molecular Cell. PMID 35907401 DOI: 10.1016/j.molcel.2022.06.019 |
0.371 |
|
2022 |
Stogios PJ, Bordeleau E, Xu Z, Skarina T, Evdokimova E, Chou S, Diorio-Toth L, D'Souza AW, Patel S, Dantas G, Wright GD, Savchenko A. Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family. Communications Biology. 5: 263. PMID 35338238 DOI: 10.1038/s42003-022-03219-w |
0.343 |
|
2021 |
Xu M, Wang W, Wright GD. Glycopeptide antibiotic discovery in the genomic era. Methods in Enzymology. 665: 325-346. PMID 35379441 DOI: 10.1016/bs.mie.2021.11.009 |
0.313 |
|
2021 |
Privalsky TM, Soohoo AM, Wang J, Walsh CT, Wright GD, Gordon EM, Gray NS, Khosla C. Prospects for Antibacterial Discovery and Development. Journal of the American Chemical Society. 143: 21127-21142. PMID 34860516 DOI: 10.1021/jacs.1c10200 |
0.594 |
|
2021 |
Alder A, Struck NS, Xu M, Johnson JW, Wang W, Pallant D, Cook MA, Rambow J, Lemcke S, Gilberger TW, Wright GD. A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity. Cell Chemical Biology. PMID 34710358 DOI: 10.1016/j.chembiol.2021.10.005 |
0.547 |
|
2021 |
Zubyk HL, Wright GD. CrpP is not a Fluoroquinolone Inactivating Enzyme. Antimicrobial Agents and Chemotherapy. PMID 34001507 DOI: 10.1128/AAC.00773-21 |
0.386 |
|
2021 |
Benoit YD, Mitchell RR, Wang W, Orlando L, Boyd AL, Tanasijevic B, Aslostovar L, Shapovalova Z, Doyle M, Bergin CJ, Vojnits K, Casado FL, Di Lu J, Porras DP, García-Rodriguez JL, ... ... Wright GD, et al. Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics. Cell Chemical Biology. PMID 33979648 DOI: 10.1016/j.chembiol.2021.04.014 |
0.647 |
|
2021 |
Surette MD, Spanogiannopoulos P, Wright GD. The Enzymes of the Rifamycin Antibiotic Resistome. Accounts of Chemical Research. PMID 33877820 DOI: 10.1021/acs.accounts.1c00048 |
0.336 |
|
2021 |
Yarlagadda V, Rao VN, Kaur M, Guitor AK, Wright GD. A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent. Acs Infectious Diseases. PMID 33826296 DOI: 10.1021/acsinfecdis.1c00040 |
0.316 |
|
2021 |
Waglechner N, Culp EJ, Wright GD. Ancient Antibiotics, Ancient Resistance. Ecosal Plus. 9. PMID 33734062 DOI: 10.1128/ecosalplus.ESP-0027-2020 |
0.343 |
|
2021 |
Hobson C, Chan AN, Wright GD. The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents. Chemical Reviews. PMID 33606500 DOI: 10.1021/acs.chemrev.0c01214 |
0.343 |
|
2021 |
Bordeleau E, Stogios PJ, Evdokimova E, Koteva K, Savchenko A, Wright GD. ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin. Mbio. 12. PMID 33563840 DOI: 10.1128/mBio.02705-20 |
0.397 |
|
2020 |
Yarlagadda V, Medina R, Johnson TA, Koteva KP, Cox G, Thaker MN, Wright GD. Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity. Acs Infectious Diseases. PMID 33164482 DOI: 10.1021/acsinfecdis.0c00467 |
0.372 |
|
2020 |
Schaenzer AJ, Wright GD. Antibiotic Resistance by Enzymatic Modification of Antibiotic Targets. Trends in Molecular Medicine. PMID 32493628 DOI: 10.1016/J.Molmed.2020.05.001 |
0.467 |
|
2020 |
Yarlagadda V, Medina R, Wright GD. Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics. Scientific Reports. 10: 8134. PMID 32424122 DOI: 10.1038/S41598-020-64756-0 |
0.452 |
|
2020 |
Jacques S, van der Sloot AM, Huard C, Coulombe-Huntington J, Tsao S, Tollis S, Bertomeu T, Culp EJ, Pallant D, Cook MA, Bonneil E, Thibault P, Wright GD, Tyers M. Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development. Genetics. PMID 32094149 DOI: 10.1534/Genetics.119.302851 |
0.359 |
|
2020 |
Culp EJ, Waglechner N, Wang W, Fiebig-Comyn AA, Hsu YP, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV, Wright GD. Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling. Nature. PMID 32051588 DOI: 10.1038/S41586-020-1990-9 |
0.439 |
|
2020 |
Rotondo CM, Sychantha D, Koteva K, Wright GD. Suppression of β-Lactam Resistance by Aspergillomarasmine A is Influenced by Both the Metallo-β-Lactamase Target and the Antibiotic Partner. Antimicrobial Agents and Chemotherapy. PMID 31932375 DOI: 10.1128/Aac.01386-19 |
0.364 |
|
2019 |
Zubyk HL, Cox G, Wright GD. Antibiotic Dereplication Using the Antibiotic Resistance Platform. Journal of Visualized Experiments : Jove. PMID 31680676 DOI: 10.3791/60536 |
0.396 |
|
2019 |
Yarlagadda V, Wright GD. Membrane-Active Rhamnolipids Overcome Aminoglycoside Resistance. Cell Chemical Biology. 26: 1333-1334. PMID 31626780 DOI: 10.1016/J.Chembiol.2019.09.015 |
0.363 |
|
2019 |
Guitor AK, Raphenya AR, Klunk J, Kuch M, Alcock B, Surette MG, McArthur AG, Poinar HN, Wright GD. Capturing the Resistome: A targeted capture method to reveal antibiotic resistance determinants in metagenomes. Antimicrobial Agents and Chemotherapy. PMID 31611361 DOI: 10.1128/Aac.01324-19 |
0.426 |
|
2019 |
Culp EJ, Yim G, Waglechner N, Wang W, Pawlowski AC, Wright GD. Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics. Nature Biotechnology. PMID 31501558 DOI: 10.1038/S41587-019-0241-9 |
0.362 |
|
2019 |
Waglechner N, McArthur AG, Wright GD. Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance. Nature Microbiology. PMID 31406334 DOI: 10.1038/S41564-019-0531-5 |
0.406 |
|
2019 |
Thomy D, Culp E, Adamek M, Cheng EY, Ziemert N, Wright GD, Sass P, Brötz-Oesterhelt H. The ADEP biosynthetic gene cluster in NRRL 15010 reveals an accessory gene as a novel antibiotic resistance factor. Applied and Environmental Microbiology. PMID 31399403 DOI: 10.1128/Aem.01292-19 |
0.435 |
|
2019 |
Wright GD. Environmental and clinical antibiotic resistomes, same only different. Current Opinion in Microbiology. 51: 57-63. PMID 31330416 DOI: 10.1016/J.Mib.2019.06.005 |
0.395 |
|
2019 |
Tyers M, Wright GD. Drug combinations: a strategy to extend the life of antibiotics in the 21st century. Nature Reviews. Microbiology. PMID 30683887 DOI: 10.1038/S41579-018-0141-X |
0.419 |
|
2019 |
Low DE, Kellner JD, Wright GD. Superbugs: How They Evolve and Minimize the Cost of Resistance. Current Infectious Disease Reports. 1: 464-469. PMID 11095825 DOI: 10.1007/S11908-999-0060-0 |
0.392 |
|
2018 |
Yim G, Wang W, Pawlowski AC, Wright GD. Tri-chlorination of a teicoplanin type glycopeptide antibiotic by the halogenase StaI evades resistance. Antimicrobial Agents and Chemotherapy. PMID 30275088 DOI: 10.1128/Aac.01540-18 |
0.427 |
|
2018 |
Guitor AK, Wright GD. Antimicrobial Resistance and Respiratory Infections. Chest. PMID 29959904 DOI: 10.1016/J.Chest.2018.06.019 |
0.447 |
|
2018 |
Cox G, Ejim L, Stogios PJ, Koteva K, Bordeleau E, Evdokimova E, Sieron AO, Savchenko A, Serio AW, Krause KM, Wright GD. Plazomicin retains antibiotic activity against most aminoglycoside modifying enzymes. Acs Infectious Diseases. PMID 29634241 DOI: 10.1021/Acsinfecdis.8B00001 |
0.47 |
|
2018 |
Stogios PJ, Cox G, Zubyk HL, Evdokimova E, Wawrzak Z, Wright GD, Savchenko A. Substrate recognition by a colistin resistance enzyme from Moraxella catarrhalis. Acs Chemical Biology. PMID 29631403 DOI: 10.1021/Acschembio.8B00116 |
0.501 |
|
2018 |
Koteva K, Cox G, Kelso JK, Surette MD, Zubyk HL, Ejim L, Stogios P, Savchenko A, Sørensen D, Wright GD. Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action. Cell Chemical Biology. PMID 29398560 DOI: 10.1016/J.Chembiol.2018.01.009 |
0.511 |
|
2018 |
Pawlowski AC, Stogios PJ, Koteva K, Skarina T, Evdokimova E, Savchenko A, Wright GD. The evolution of substrate discrimination in macrolide antibiotic resistance enzymes. Nature Communications. 9: 112. PMID 29317655 DOI: 10.1038/S41467-017-02680-0 |
0.516 |
|
2017 |
Pawlowski AC, Westman EL, Koteva K, Waglechner N, Wright GD. The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies. The Isme Journal. PMID 29259290 DOI: 10.1038/S41396-017-0017-5 |
0.438 |
|
2017 |
Yan A, Culp E, Perry J, Lau J, MacNeil L, Surette MG, Wright GD. Transformation of the anticancer drug doxorubicin in the human gut microbiome. Acs Infectious Diseases. PMID 29160065 DOI: 10.1021/Acsinfecdis.7B00166 |
0.323 |
|
2017 |
Rotondo CM, Wright GD. Inhibitors of metallo-β-lactamases. Current Opinion in Microbiology. 39: 96-105. PMID 29154026 DOI: 10.1016/J.Mib.2017.10.026 |
0.39 |
|
2017 |
Bergstrom A, Katko A, Adkins ZB, Hill JE, Cheng Z, Burnett ML, Yang H, Aitha M, Mehaffey MR, Brodbelt JS, Tehrani KHME, Martin NI, Bonomo RA, Page RC, Tierney DL, ... ... Wright GD, et al. Probing the interaction of Aspergillomarasmine A (AMA) with metallo-β-lactamases NDM-1, VIM-2, and IMP-7. Acs Infectious Diseases. PMID 29091730 DOI: 10.1021/Acsinfecdis.7B00106 |
0.309 |
|
2017 |
Waglechner N, Wright GD. Antibiotic resistance: it's bad, but why isn't it worse? Bmc Biology. 15: 84. PMID 28915805 DOI: 10.1186/S12915-017-0423-1 |
0.434 |
|
2017 |
Surette M, Wright GD. Lessons from the Environmental Antibiotic Resistome. Annual Review of Microbiology. PMID 28657887 DOI: 10.1146/Annurev-Micro-090816-093420 |
0.409 |
|
2017 |
Wright GD. Opportunities for natural products in 21(st) century antibiotic discovery. Natural Product Reports. PMID 28569300 DOI: 10.1039/C7Np00019G |
0.374 |
|
2017 |
Smith NM, Bulman ZP, Sieron AO, Bulitta JB, Holden PN, Nation RL, Li J, Wright GD, Tsuji BT. Pharmacodynamics of dose-escalated 'front-loading' polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli. The Journal of Antimicrobial Chemotherapy. PMID 28505268 DOI: 10.1093/Jac/Dkx121 |
0.387 |
|
2016 |
Cox G, Sieron A, King AM, De Pascale G, Pawlowski AC, Koteva K, Wright GD. A Common Platform for Antibiotic Dereplication and Adjuvant Discovery. Cell Chemical Biology. PMID 28017602 DOI: 10.1016/J.Chembiol.2016.11.011 |
0.448 |
|
2016 |
Pawlowski AC, Wang W, Koteva K, Barton HA, McArthur AG, Wright GD. A diverse intrinsic antibiotic resistome from a cave bacterium. Nature Communications. 7: 13803. PMID 27929110 DOI: 10.1038/Ncomms13803 |
0.439 |
|
2016 |
Culp E, Wright GD. Bacterial proteases, untapped antimicrobial drug targets. The Journal of Antibiotics. PMID 27899793 DOI: 10.1038/Ja.2016.138 |
0.417 |
|
2016 |
Brieke C, Yim G, Peschke M, Wright GD, Cryle MJ. Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates. Chemical Communications (Cambridge, England). PMID 27812569 DOI: 10.1039/C6Cc06975D |
0.348 |
|
2016 |
Jia B, Raphenya AR, Alcock B, Waglechner N, Guo P, Tsang KK, Lago BA, Dave BM, Pereira S, Sharma AN, Doshi S, Courtot M, Lo R, Williams LE, Frye JG, ... ... Wright GD, et al. CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Research. PMID 27789705 DOI: 10.1093/Nar/Gkw1004 |
0.394 |
|
2016 |
Robbins N, Wright GD, Cowen LE. Antifungal Drugs: The Current Armamentarium and Development of New Agents. Microbiology Spectrum. 4. PMID 27763259 DOI: 10.1128/Microbiolspec.Funk-0002-2016 |
0.314 |
|
2016 |
Yim G, Wang W, Thaker MN, Tan S, Wright GD. How To Make a Glycopeptide: A Synthetic Biology Approach To Expand Antibiotic Chemical Diversity. Acs Infectious Diseases. 2: 642-650. PMID 27759388 DOI: 10.1021/Acsinfecdis.6B00105 |
0.449 |
|
2016 |
Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GD. Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function. Cell Chemical Biology. PMID 27746129 DOI: 10.1016/J.Chembiol.2016.08.015 |
0.339 |
|
2016 |
Wright GD. Empowering Older Antibiotics. Cell. 167: 301. PMID 27716499 DOI: 10.1016/J.Cell.2016.09.032 |
0.377 |
|
2016 |
Albu SA, Koteva K, King AM, Al-Karmi S, Wright GD, Capretta A. Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure-Activity Relationships. Angewandte Chemie (International Ed. in English). PMID 27633338 DOI: 10.1002/Anie.201606657 |
0.346 |
|
2016 |
Wright GD. Antibiotic Adjuvants: Rescuing Antibiotics from Resistance: (Trends in Microbiology 24, First page[en dash]Last page; October 17, 2016). Trends in Microbiology. PMID 27522372 DOI: 10.1016/J.Tim.2016.07.008 |
0.422 |
|
2016 |
Wright GD. Antibiotic Adjuvants: Rescuing Antibiotics from Resistance. Trends in Microbiology. PMID 27430191 DOI: 10.1016/J.Tim.2016.06.009 |
0.449 |
|
2016 |
Spitzer M, Robbins N, Wright GD. Combinatorial Strategies For Combating Invasive Fungal Infections. Virulence. 0. PMID 27268286 DOI: 10.1080/21505594.2016.1196300 |
0.328 |
|
2016 |
Perry J, Waglechner N, Wright G. The Prehistory of Antibiotic Resistance. Cold Spring Harbor Perspectives in Medicine. 6. PMID 27252395 DOI: 10.1101/Cshperspect.A025197 |
0.433 |
|
2016 |
Pawlowski AC, Johnson JW, Wright GD. Evolving medicinal chemistry strategies in antibiotic discovery. Current Opinion in Biotechnology. 42: 108-117. PMID 27116217 DOI: 10.1016/J.Copbio.2016.04.006 |
0.65 |
|
2016 |
Stogios PJ, Cox G, Spanogiannopoulos P, Pillon MC, Waglechner N, Skarina T, Koteva K, Guarné A, Savchenko A, Wright GD. Rifampin phosphotransferase is an unusual antibiotic resistance kinase. Nature Communications. 7: 11343. PMID 27103605 DOI: 10.1038/Ncomms11343 |
0.472 |
|
2016 |
Brown ED, Wright GD. Antibacterial drug discovery in the resistance era. Nature. 529: 336-43. PMID 26791724 DOI: 10.1038/Nature17042 |
0.428 |
|
2016 |
King AM, King DT, French S, Brouillette E, Asli A, Alexander JA, Vuckovic M, Maiti SN, Parr TR, Brown ED, Malouin F, Strynadka NC, Wright GD. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. Acs Chemical Biology. PMID 26731698 DOI: 10.1021/Acschembio.5B00944 |
0.419 |
|
2016 |
Garneau-Tsodikova S, Wright GD. Antibiotic Resistance themed issue Medchemcomm. 7: 10. DOI: 10.1039/C5Md90063H |
0.628 |
|
2016 |
Wright GD. Solving the Antibiotic Crisis Acs Infectious Diseases. 1: 80-84. DOI: 10.1021/id500052s |
0.326 |
|
2016 |
Falconer SB, Reid-Yu SA, King AM, Gehrke SS, Wang W, Britten JF, Coombes BK, Wright GD, Brown ED. Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae Acs Infectious Diseases. 1: 533-543. DOI: 10.1021/acsinfecdis.5b00033 |
0.34 |
|
2015 |
Falconer SB, Reid-Yu SA, King AM, Gehrke SS, Wang W, Britten JF, Coombes BK, Wright GD, Brown ED. Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae. Acs Infectious Diseases. 1: 533-543. PMID 27623408 DOI: 10.1021/Acsinfecdis.5B00033 |
0.449 |
|
2015 |
Frasch HJ, Kalan L, Kilian R, Martin T, Wright GD, Stegmann E. Alternative Pathway to a Glycopeptide-Resistant Cell Wall in the Balhimycin Producer Amycolatopsis balhimycina. Acs Infectious Diseases. 1: 243-52. PMID 27622740 DOI: 10.1021/Acsinfecdis.5B00011 |
0.351 |
|
2015 |
King DT, King AM, Lal SM, Wright GD, Strynadka NC. Molecular Mechanism of Avibactam-Mediated β-Lactamase Inhibition. Acs Infectious Diseases. 1: 175-84. PMID 27622530 DOI: 10.1021/Acsinfecdis.5B00007 |
0.351 |
|
2015 |
Wright GD. Solving the Antibiotic Crisis. Acs Infectious Diseases. 1: 80-4. PMID 27622298 DOI: 10.1021/Id500052S |
0.44 |
|
2015 |
Koteva K, King AM, Capretta A, Wright GD. Total Synthesis and Activity of the Metallo-β-lactamase Inhibitor Aspergillomarasmine A. Angewandte Chemie (International Ed. in English). PMID 26709849 DOI: 10.1002/Anie.201510057 |
0.409 |
|
2015 |
Robbins N, Spitzer M, Yu T, Cerone RP, Averette AK, Bahn YS, Heitman J, Sheppard DC, Tyers M, Wright GD. An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens. Cell Reports. PMID 26549450 DOI: 10.1016/J.Celrep.2015.10.018 |
0.36 |
|
2015 |
Freschi L, Jeukens J, Kukavica-Ibrulj I, Boyle B, Dupont MJ, Laroche J, Larose S, Maaroufi H, Fothergill JL, Moore M, Winsor GL, Aaron SD, Barbeau J, Bell SC, Burns JL, ... ... Wright GD, et al. Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium. Frontiers in Microbiology. 6: 1036. PMID 26483767 DOI: 10.3389/Fmicb.2015.01036 |
0.336 |
|
2015 |
Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Wright GD, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/Nchembio.1890 |
0.746 |
|
2015 |
McArthur AG, Wright GD. Bioinformatics of antimicrobial resistance in the age of molecular epidemiology. Current Opinion in Microbiology. 27: 45-50. PMID 26241506 DOI: 10.1016/J.Mib.2015.07.004 |
0.416 |
|
2015 |
Stogios PJ, Evdokimova E, Morar M, Koteva K, Wright GD, Courvalin P, Savchenko A. Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu(A) and lnu(D). Journal of Molecular Biology. 427: 2229-43. PMID 25900373 DOI: 10.1016/J.Jmb.2015.04.008 |
0.512 |
|
2015 |
Wright GD, Yoshida M. Winners of the 2014 JA Medals for excellence. The Journal of Antibiotics. 68: 1-2. PMID 25623837 DOI: 10.1038/Ja.2014.156 |
0.345 |
|
2015 |
Cox G, Stogios PJ, Savchenko A, Wright GD. Structural and molecular basis for resistance to aminoglycoside antibiotics by the adenylyltransferase ANT(2″)-Ia. Mbio. 6. PMID 25564464 DOI: 10.1128/Mbio.02180-14 |
0.541 |
|
2015 |
Wright G. Antibiotics: An irresistible newcomer Nature. 517: 442-444. PMID 25561172 DOI: 10.1038/Nature14193 |
0.373 |
|
2015 |
Thaker MN, Kalan L, Waglechner N, Eshaghi A, Patel SN, Poutanen S, Willey B, Coburn B, McGeer A, Low DE, Wright GD. Vancomycin-variable enterococci can give rise to constitutive resistance during antibiotic therapy. Antimicrobial Agents and Chemotherapy. 59: 1405-10. PMID 25512425 DOI: 10.1128/Aac.04490-14 |
0.414 |
|
2015 |
Thaker MN, Wright GD. Opportunities for synthetic biology in antibiotics: expanding glycopeptide chemical diversity. Acs Synthetic Biology. 4: 195-206. PMID 23654249 DOI: 10.1021/Sb300092N |
0.426 |
|
2014 |
Hirsch DR, Cox G, D'Erasmo MP, Shakya T, Meck C, Mohd N, Wright GD, Murelli RP. Inhibition of the ANT(2")-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones. Bioorganic & Medicinal Chemistry Letters. 24: 4943-7. PMID 25283553 DOI: 10.1016/J.Bmcl.2014.09.037 |
0.488 |
|
2014 |
Perry JA, Westman EL, Wright GD. The antibiotic resistome: what's new? Current Opinion in Microbiology. 21: 45-50. PMID 25280222 DOI: 10.1016/J.Mib.2014.09.002 |
0.383 |
|
2014 |
Yim G, Kalan L, Koteva K, Thaker MN, Waglechner N, Tang I, Wright GD. Harnessing the synthetic capabilities of glycopeptide antibiotic tailoring enzymes: characterization of the UK-68,597 biosynthetic cluster. Chembiochem : a European Journal of Chemical Biology. 15: 2613-23. PMID 25255985 DOI: 10.1002/Cbic.201402179 |
0.419 |
|
2014 |
Perry JA, Wright GD. Forces shaping the antibiotic resistome. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 1179-84. PMID 25213620 DOI: 10.1002/Bies.201400128 |
0.408 |
|
2014 |
Nguyen UT, Harvey H, Hogan AJ, Afonso AC, Wright GD, Burrows LL. Role of PBPD1 in stimulation of Listeria monocytogenes biofilm formation by subminimal inhibitory β-lactam concentrations. Antimicrobial Agents and Chemotherapy. 58: 6508-17. PMID 25136010 DOI: 10.1128/Aac.03671-14 |
0.334 |
|
2014 |
King AM, Reid-Yu SA, Wang W, King DT, De Pascale G, Strynadka NC, Walsh TR, Coombes BK, Wright GD. Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance. Nature. 510: 503-6. PMID 24965651 DOI: 10.1038/Nature13445 |
0.461 |
|
2014 |
Spanogiannopoulos P, Waglechner N, Koteva K, Wright GD. A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria. Proceedings of the National Academy of Sciences of the United States of America. 111: 7102-7. PMID 24778229 DOI: 10.1073/Pnas.1402358111 |
0.486 |
|
2014 |
Cox G, Koteva K, Wright GD. An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria. The Journal of Antimicrobial Chemotherapy. 69: 1844-55. PMID 24627312 DOI: 10.1093/Jac/Dku057 |
0.447 |
|
2014 |
Wright GD. Something old, something new: revisiting natural products in antibiotic drug discovery. Canadian Journal of Microbiology. 60: 147-54. PMID 24588388 DOI: 10.1139/Cjm-2014-0063 |
0.384 |
|
2014 |
Martin-Laurent F, Marti R, Waglechner N, Wright GD, Topp E. Draft Genome Sequence of the Sulfonamide Antibiotic-Degrading Microbacterium sp. Strain C448. Genome Announcements. 2. PMID 24526651 DOI: 10.1128/Genomea.01113-13 |
0.313 |
|
2014 |
Wright GD. Christopher Walsh: Pioneer and innovator in antibiotic and natural product chemical biology. The Journal of Antibiotics. 67: 5-6. PMID 24463296 DOI: 10.1038/Ja.2013.118 |
0.31 |
|
2014 |
Farha MA, Koteva K, Gale RT, Sewell EW, Wright GD, Brown ED. Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites. Bioorganic & Medicinal Chemistry Letters. 24: 905-10. PMID 24393581 DOI: 10.1016/J.Bmcl.2013.12.069 |
0.423 |
|
2014 |
Falconer SB, Wang W, Gehrke SS, Cuneo JD, Britten JF, Wright GD, Brown ED. Metal-induced isomerization yields an intracellular chelator that disrupts bacterial iron homeostasis. Chemistry & Biology. 21: 136-45. PMID 24361049 DOI: 10.1016/J.Chembiol.2013.11.007 |
0.351 |
|
2014 |
Yim G, Thaker MN, Koteva K, Wright G. Glycopeptide antibiotic biosynthesis Journal of Antibiotics. 67: 31-41. PMID 24220108 DOI: 10.1038/Ja.2013.117 |
0.47 |
|
2013 |
Laxminarayan R, Duse A, Wattal C, Zaidi AK, Wertheim HF, Sumpradit N, Vlieghe E, Hara GL, Gould IM, Goossens H, Greko C, So AD, Bigdeli M, Tomson G, Woodhouse W, ... ... Wright GD, et al. Antibiotic resistance-the need for global solutions. The Lancet. Infectious Diseases. 13: 1057-98. PMID 24252483 DOI: 10.1016/S1473-3099(13)70318-9 |
0.372 |
|
2013 |
Thaker MN, Wang W, Spanogiannopoulos P, Waglechner N, King AM, Medina R, Wright GD. Identifying producers of antibacterial compounds by screening for antibiotic resistance. Nature Biotechnology. 31: 922-7. PMID 24056948 DOI: 10.1038/Nbt.2685 |
0.406 |
|
2013 |
Westman EL, Yan M, Waglechner N, Koteva K, Wright GD. Self resistance to the atypical cationic antimicrobial peptide edeine of Brevibacillus brevis Vm4 by the N-acetyltransferase EdeQ. Chemistry & Biology. 20: 983-90. PMID 23891151 DOI: 10.1016/J.Chembiol.2013.06.010 |
0.401 |
|
2013 |
Frawley ER, Crouch ML, Bingham-Ramos LK, Robbins HF, Wang W, Wright GD, Fang FC. Iron and citrate export by a major facilitator superfamily pump regulates metabolism and stress resistance in Salmonella Typhimurium. Proceedings of the National Academy of Sciences of the United States of America. 110: 12054-9. PMID 23821749 DOI: 10.1073/Pnas.1218274110 |
0.323 |
|
2013 |
Gaze WH, Krone SM, Larsson DG, Li XZ, Robinson JA, Simonet P, Smalla K, Timinouni M, Topp E, Wellington EM, Wright GD, Zhu YG. Influence of humans on evolution and mobilization of environmental antibiotic resistome. Emerging Infectious Diseases. 19. PMID 23764294 DOI: 10.3201/Eid1907.120871 |
0.35 |
|
2013 |
Stogios PJ, Spanogiannopoulos P, Evdokimova E, Egorova O, Shakya T, Todorovic N, Capretta A, Wright GD, Savchenko A. Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance. The Biochemical Journal. 454: 191-200. PMID 23758273 DOI: 10.1042/Bj20130317 |
0.535 |
|
2013 |
Perry JA, Wright GD. The antibiotic resistance "mobilome": searching for the link between environment and clinic. Frontiers in Microbiology. 4: 138. PMID 23755047 DOI: 10.3389/Fmicb.2013.00138 |
0.435 |
|
2013 |
Wright GD. Q&A: antibiotic resistance: what more do we know and what more can we do? Bmc Biology. 11: 51. PMID 23683650 DOI: 10.1186/1741-7007-11-51 |
0.42 |
|
2013 |
Wright GD, Hung DT, Helmann JD. How antibiotics kill bacteria: new models needed? Nature Medicine. 19: 544-5. PMID 23652106 DOI: 10.1038/Nm.3198 |
0.561 |
|
2013 |
McArthur AG, Waglechner N, Nizam F, Yan A, Azad MA, Baylay AJ, Bhullar K, Canova MJ, De Pascale G, Ejim L, Kalan L, King AM, Koteva K, Morar M, Mulvey MR, ... ... Wright GD, et al. The comprehensive antibiotic resistance database. Antimicrobial Agents and Chemotherapy. 57: 3348-57. PMID 23650175 DOI: 10.1128/Aac.00419-13 |
0.405 |
|
2013 |
Cox G, Wright GD. Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions. International Journal of Medical Microbiology : Ijmm. 303: 287-92. PMID 23499305 DOI: 10.1016/J.Ijmm.2013.02.009 |
0.447 |
|
2013 |
Kalan L, Perry J, Koteva K, Thaker M, Wright G. Glycopeptide sulfation evades resistance Journal of Bacteriology. 195: 167-171. PMID 23104813 DOI: 10.1128/Jb.01617-12 |
0.491 |
|
2013 |
Farha MA, Leung A, Sewell EW, D'Elia MA, Allison SE, Ejim L, Pereira PM, Pinho MG, Wright GD, Brown ED. Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams. Acs Chemical Biology. 8: 226-33. PMID 23062620 DOI: 10.1021/Cb300413M |
0.442 |
|
2012 |
Westman EL, Canova MJ, Radhi IJ, Koteva K, Kireeva I, Waglechner N, Wright GD. Bacterial inactivation of the anticancer drug doxorubicin. Chemistry & Biology. 19: 1255-64. PMID 23102220 DOI: 10.1016/J.Chembiol.2012.08.011 |
0.371 |
|
2012 |
Wright GD. The origins of antibiotic resistance. Handbook of Experimental Pharmacology. 13-30. PMID 23090593 DOI: 10.1007/978-3-642-28951-4_2 |
0.441 |
|
2012 |
Wright GD. Back to the future: a new 'old' lead for tuberculosis. Embo Molecular Medicine. 4: 1029-31. PMID 22987753 DOI: 10.1002/Emmm.201201811 |
0.325 |
|
2012 |
Spanogiannopoulos P, Thaker M, Koteva K, Waglechner N, Wright GD. Characterization of a rifampin-inactivating glycosyltransferase from a screen of environmental actinomycetes. Antimicrobial Agents and Chemotherapy. 56: 5061-9. PMID 22802246 DOI: 10.1128/Aac.01166-12 |
0.485 |
|
2012 |
Shi R, Munger C, Kalan L, Sulea T, Wright GD, Cygler M. Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold. Proceedings of the National Academy of Sciences of the United States of America. 109: 11824-9. PMID 22753479 DOI: 10.1073/Pnas.1205377109 |
0.475 |
|
2012 |
Taylor PL, Rossi L, De Pascale G, Wright GD. A forward chemical screen identifies antibiotic adjuvants in Escherichia coli. Acs Chemical Biology. 7: 1547-55. PMID 22698393 DOI: 10.1021/Cb300269G |
0.438 |
|
2012 |
Bhullar K, Waglechner N, Pawlowski A, Koteva K, Banks ED, Johnston MD, Barton HA, Wright GD. Antibiotic resistance is prevalent in an isolated cave microbiome. Plos One. 7: e34953. PMID 22509370 DOI: 10.1371/Journal.Pone.0034953 |
0.476 |
|
2012 |
Drudge CN, Elliott AV, Plach JM, Ejim LJ, Wright GD, Droppo IG, Warren LA. Diversity of integron- and culture-associated antibiotic resistance genes in freshwater floc. Applied and Environmental Microbiology. 78: 4367-72. PMID 22467502 DOI: 10.1128/Aem.00405-12 |
0.395 |
|
2012 |
Morar M, Pengelly K, Koteva K, Wright GD. Mechanism and diversity of the erythromycin esterase family of enzymes. Biochemistry. 51: 1740-51. PMID 22303981 DOI: 10.1021/Bi201790U |
0.515 |
|
2012 |
Wright GD, Poinar H. Antibiotic resistance is ancient: implications for drug discovery. Trends in Microbiology. 20: 157-9. PMID 22284896 DOI: 10.1016/J.Tim.2012.01.002 |
0.435 |
|
2012 |
Wright GD. Antibiotics: a new hope. Chemistry & Biology. 19: 3-10. PMID 22284349 DOI: 10.1016/J.Chembiol.2011.10.019 |
0.408 |
|
2012 |
Nguyen UT, Wenderska IB, Chong MA, Koteva K, Wright GD, Burrows LL. Small-molecule modulators of Listeria monocytogenes biofilm development. Applied and Environmental Microbiology. 78: 1454-65. PMID 22194285 DOI: 10.1128/Aem.07227-11 |
0.349 |
|
2012 |
D'Costa VM, Mukhtar TA, Patel T, Koteva K, Waglechner N, Hughes DW, Wright GD, De Pascale G. Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanisms. Antimicrobial Agents and Chemotherapy. 56: 757-64. PMID 22083474 DOI: 10.1128/Aac.05441-11 |
0.478 |
|
2012 |
Thaker MN, García M, Koteva K, Waglechner N, Sorensen D, Medina R, Wright GD. Biosynthetic gene cluster and antimicrobial activity of the elfamycin antibiotic factumycin Medchemcomm. 3: 1020-1026. DOI: 10.1039/C2Md20038D |
0.46 |
|
2011 |
Shakya T, Stogios PJ, Waglechner N, Evdokimova E, Ejim L, Blanchard JE, McArthur AG, Savchenko A, Wright GD. A small molecule discrimination map of the antibiotic resistance kinome. Chemistry & Biology. 18: 1591-601. PMID 22195561 DOI: 10.1016/J.Chembiol.2011.10.018 |
0.457 |
|
2011 |
Wenderska IB, Chong M, McNulty J, Wright GD, Burrows LL. Palmitoyl-DL-carnitine is a multitarget inhibitor of Pseudomonas aeruginosa biofilm development. Chembiochem : a European Journal of Chemical Biology. 12: 2759-66. PMID 22045628 DOI: 10.1002/Cbic.201100500 |
0.382 |
|
2011 |
D'Costa VM, King CE, Kalan L, Morar M, Sung WW, Schwarz C, Froese D, Zazula G, Calmels F, Debruyne R, Golding GB, Poinar HN, Wright GD. Antibiotic resistance is ancient. Nature. 477: 457-61. PMID 21881561 DOI: 10.1038/Nature10388 |
0.443 |
|
2011 |
Spitzer M, Griffiths E, Blakely KM, Wildenhain J, Ejim L, Rossi L, De Pascale G, Curak J, Brown E, Tyers M, Wright GD. Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole. Molecular Systems Biology. 7: 499. PMID 21694716 DOI: 10.1038/Msb.2011.31 |
0.349 |
|
2011 |
De Pascale G, Griffiths EJ, Shakya T, Nazi I, Wright GD. Identification and characterization of new inhibitors of fungal homoserine kinase. Chembiochem : a European Journal of Chemical Biology. 12: 1179-82. PMID 21538764 DOI: 10.1002/Cbic.201100121 |
0.307 |
|
2011 |
De Pascale G, Nazi I, Harrison PH, Wright GD. β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents. The Journal of Antibiotics. 64: 483-7. PMID 21522158 DOI: 10.1038/Ja.2011.37 |
0.451 |
|
2011 |
Ejim L, Farha MA, Falconer SB, Wildenhain J, Coombes BK, Tyers M, Brown ED, Wright GD. Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nature Chemical Biology. 7: 348-50. PMID 21516114 DOI: 10.1038/Nchembio.559 |
0.397 |
|
2011 |
Volkers G, Palm GJ, Weiss MS, Wright GD, Hinrichs W. Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase. Febs Letters. 585: 1061-6. PMID 21402075 DOI: 10.1016/J.Febslet.2011.03.012 |
0.481 |
|
2011 |
Kalan L, Wright GD. Antibiotic adjuvants: multicomponent anti-infective strategies. Expert Reviews in Molecular Medicine. 13: e5. PMID 21342612 DOI: 10.1017/S1462399410001766 |
0.442 |
|
2011 |
Wright GD. Molecular mechanisms of antibiotic resistance. Chemical Communications (Cambridge, England). 47: 4055-61. PMID 21286630 DOI: 10.1039/C0Cc05111J |
0.448 |
|
2011 |
Stogios PJ, Shakya T, Evdokimova E, Savchenko A, Wright GD. Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme. The Journal of Biological Chemistry. 286: 1966-75. PMID 21084294 DOI: 10.1074/Jbc.M110.194266 |
0.483 |
|
2011 |
Stogios PJ, Shakya T, Evdokimova E, Savchenko A, Wright GD. Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme (Journal of Biological Chemistry (2011) 286, (1966-1975)) Journal of Biological Chemistry. 286: 42786. DOI: 10.1074/jbc.A110.194266 |
0.301 |
|
2010 |
Wright GD. The antibiotic resistome. Expert Opinion On Drug Discovery. 5: 779-88. PMID 22827799 DOI: 10.1517/17460441.2010.497535 |
0.441 |
|
2010 |
Wright GD. Q&A: Antibiotic resistance: where does it come from and what can we do about it? Bmc Biology. 8: 123. PMID 20887638 DOI: 10.1186/1741-7007-8-123 |
0.364 |
|
2010 |
Li DH, Chung YS, Gloyd M, Joseph E, Ghirlando R, Wright GD, Cheng YQ, Maurizi MR, Guarné A, Ortega J. Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP. Chemistry & Biology. 17: 959-69. PMID 20851345 DOI: 10.1016/J.Chembiol.2010.07.008 |
0.386 |
|
2010 |
Wright GD. Antibiotic resistance in the environment: a link to the clinic? Current Opinion in Microbiology. 13: 589-94. PMID 20850375 DOI: 10.1016/J.Mib.2010.08.005 |
0.429 |
|
2010 |
Morar M, Wright GD. The genomic enzymology of antibiotic resistance. Annual Review of Genetics. 44: 25-51. PMID 20822442 DOI: 10.1146/Annurev-Genet-102209-163517 |
0.443 |
|
2010 |
De Pascale G, Wright GD. Antibiotic resistance by enzyme inactivation: from mechanisms to solutions. Chembiochem : a European Journal of Chemical Biology. 11: 1325-34. PMID 20564281 DOI: 10.1002/Cbic.201000067 |
0.451 |
|
2010 |
Koteva K, Hong HJ, Wang XD, Nazi I, Hughes D, Naldrett MJ, Buttner MJ, Wright GD. A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor. Nature Chemical Biology. 6: 327-9. PMID 20383152 DOI: 10.1038/Nchembio.350 |
0.373 |
|
2010 |
Shakya T, Wright GD. Nucleotide selectivity of antibiotic kinases. Antimicrobial Agents and Chemotherapy. 54: 1909-13. PMID 20231391 DOI: 10.1128/Aac.01570-09 |
0.503 |
|
2010 |
McKenzie NL, Thaker M, Koteva K, Hughes DW, Wright GD, Nodwell JR. Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1. The Journal of Antibiotics. 63: 177-82. PMID 20224601 DOI: 10.1038/Ja.2010.13 |
0.406 |
|
2010 |
Wright GD. Antibiotics: inactive but not inert. Nature Chemical Biology. 6: 85-6. PMID 20081820 DOI: 10.1038/Nchembio.299 |
0.461 |
|
2010 |
Taylor PL, Sugiman-Marangos S, Zhang K, Valvano MA, Wright GD, Junop MS. Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coli. Biochemistry. 49: 1033-41. PMID 20050699 DOI: 10.1021/Bi901780J |
0.396 |
|
2010 |
Thaker M, Spanogiannopoulos P, Wright GD. The tetracycline resistome. Cellular and Molecular Life Sciences : Cmls. 67: 419-31. PMID 19862477 DOI: 10.1007/S00018-009-0172-6 |
0.455 |
|
2009 |
Morar M, Bhullar K, Hughes DW, Junop M, Wright GD. Structure and mechanism of the lincosamide antibiotic adenylyltransferase LinB. Structure (London, England : 1993). 17: 1649-59. PMID 20004168 DOI: 10.1016/J.Str.2009.10.013 |
0.494 |
|
2009 |
Wright GD. Making sense of antisense in antibiotic drug discovery. Cell Host & Microbe. 6: 197-8. PMID 19748460 DOI: 10.1016/J.Chom.2009.08.009 |
0.362 |
|
2009 |
Walsh CT, Wright GD. Antimicrobials. Current Opinion in Microbiology. 12: 473-5. PMID 19733112 DOI: 10.1016/j.mib.2009.08.002 |
0.545 |
|
2009 |
Kalan L, Ebert S, Kelly T, Wright GD. Noncanonical vancomycin resistance cluster from Desulfitobacterium hafniense Y51. Antimicrobial Agents and Chemotherapy. 53: 2841-5. PMID 19414574 DOI: 10.1128/Aac.01408-08 |
0.429 |
|
2009 |
Shi R, Lamb SS, Zakeri B, Proteau A, Cui Q, Sulea T, Matte A, Wright GD, Cygler M. Structure and function of the glycopeptide N-methyltransferase MtfA, a tool for the biosynthesis of modified glycopeptide antibiotics. Chemistry & Biology. 16: 401-10. PMID 19389626 DOI: 10.1016/J.Chembiol.2009.02.007 |
0.431 |
|
2008 |
Taylor PL, Wright GD. Novel approaches to discovery of antibacterial agents. Animal Health Research Reviews / Conference of Research Workers in Animal Diseases. 9: 237-46. PMID 19006597 DOI: 10.1017/S1466252308001527 |
0.416 |
|
2008 |
Pereira MP, Schertzer JW, D'Elia MA, Koteva KP, Hughes DW, Wright GD, Brown ED. The wall teichoic acid polymerase TagF efficiently synthesizes poly(glycerol phosphate) on the TagB product lipid III. Chembiochem : a European Journal of Chemical Biology. 9: 1385-90. PMID 18465758 DOI: 10.1002/Cbic.200800026 |
0.324 |
|
2008 |
Zakeri B, Wright GD. Chemical biology of tetracycline antibiotics. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 86: 124-36. PMID 18443626 DOI: 10.1139/O08-002 |
0.311 |
|
2008 |
Baysarowich J, Koteva K, Hughes DW, Ejim L, Griffiths E, Zhang K, Junop M, Wright GD. Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr. Proceedings of the National Academy of Sciences of the United States of America. 105: 4886-91. PMID 18349144 DOI: 10.1073/Pnas.0711939105 |
0.514 |
|
2008 |
Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS. Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants. The Journal of Biological Chemistry. 283: 2835-45. PMID 18056714 DOI: 10.1074/Jbc.M706163200 |
0.431 |
|
2007 |
D'Costa VM, Griffiths E, Wright GD. Expanding the soil antibiotic resistome: exploring environmental diversity. Current Opinion in Microbiology. 10: 481-9. PMID 17951101 DOI: 10.1016/J.Mib.2007.08.009 |
0.4 |
|
2007 |
Korczynska M, Mukhtar TA, Wright GD, Berghuis AM. Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase. Proceedings of the National Academy of Sciences of the United States of America. 104: 10388-93. PMID 17563376 DOI: 10.1073/Pnas.0701809104 |
0.472 |
|
2007 |
Wright GD, Sutherland AD. New strategies for combating multidrug-resistant bacteria. Trends in Molecular Medicine. 13: 260-7. PMID 17493872 DOI: 10.1016/J.Molmed.2007.04.004 |
0.437 |
|
2007 |
Nazi I, Scott A, Sham A, Rossi L, Williamson PR, Kronstad JW, Wright GD. Role of homoserine transacetylase as a new target for antifungal agents. Antimicrobial Agents and Chemotherapy. 51: 1731-6. PMID 17353245 DOI: 10.1128/Aac.01400-06 |
0.411 |
|
2007 |
Wright GD. Biochemistry. A new target for antibiotic development. Science (New York, N.Y.). 315: 1373-4. PMID 17347430 DOI: 10.1126/Science.1140374 |
0.334 |
|
2007 |
Shi R, Lamb SS, Bhat S, Sulea T, Wright GD, Matte A, Cygler M. Crystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensis. The Journal of Biological Chemistry. 282: 13073-86. PMID 17329243 DOI: 10.1074/Jbc.M611912200 |
0.425 |
|
2007 |
Ejim LJ, Blanchard JE, Koteva KP, Sumerfield R, Elowe NH, Chechetto JD, Brown ED, Junop MS, Wright GD. Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function. Journal of Medicinal Chemistry. 50: 755-64. PMID 17300162 DOI: 10.1021/Jm061132R |
0.438 |
|
2007 |
Wright GD. The antibiotic resistome: the nexus of chemical and genetic diversity. Nature Reviews. Microbiology. 5: 175-86. PMID 17277795 DOI: 10.1038/Nrmicro1614 |
0.421 |
|
2007 |
Shakya T, Wright GD. Mechanisms of Aminoglycoside Antibiotic Resistance Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery. 119-140. DOI: 10.1002/9780470149676.ch3 |
0.303 |
|
2006 |
Gao F, Yan X, Shakya T, Baettig OM, Ait-Mohand-Brunet S, Berghuis AM, Wright GD, Auclair K. Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferases. Journal of Medicinal Chemistry. 49: 5273-81. PMID 16913716 DOI: 10.1021/Jm060732N |
0.45 |
|
2006 |
De Leon GP, Elowe NH, Koteva KP, Valvano MA, Wright GD. An in vitro screen of bacterial lipopolysaccharide biosynthetic enzymes identifies an inhibitor of ADP-heptose biosynthesis. Chemistry & Biology. 13: 437-41. PMID 16632256 DOI: 10.1016/J.Chembiol.2006.02.010 |
0.364 |
|
2006 |
Lamb SS, Patel T, Koteva KP, Wright GD. Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaL. Chemistry & Biology. 13: 171-81. PMID 16492565 DOI: 10.1016/J.Chembiol.2005.12.003 |
0.362 |
|
2006 |
D'Costa VM, McGrann KM, Hughes DW, Wright GD. Sampling the antibiotic resistome Science. 311: 374-377. PMID 16424339 DOI: 10.1126/Science.1120800 |
0.422 |
|
2005 |
Mirza IA, Nazi I, Korczynska M, Wright GD, Berghuis AM. Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of α/β-hydrolases Biochemistry. 44: 15768-15773. PMID 16313180 DOI: 10.1021/Bi051951Y |
0.373 |
|
2005 |
Nazi I, Wright GD. Catalytic mechanism of fungal homoserine transacetylase Biochemistry. 44: 13560-13566. PMID 16216079 DOI: 10.1021/Bi0514764 |
0.436 |
|
2005 |
Boehr DD, Farley AR, LaRonde FJ, Murdock TR, Wright GD, Cox JR. Establishing the principles of recognition in the adenine-binding region of an aminoglycoside antibiotic kinase [APH(3')-IIIa]. Biochemistry. 44: 12445-53. PMID 16156657 DOI: 10.1021/Bi051085P |
0.683 |
|
2005 |
Moore IF, Hughes DW, Wright GD. Tigecycline is modified by the flavin-dependent monooxygenase TetX. Biochemistry. 44: 11829-35. PMID 16128584 DOI: 10.1021/Bi0506066 |
0.454 |
|
2005 |
Wright GD. Allostery trumps antibiotic resistance Structure. 13: 1089-1090. PMID 16084378 DOI: 10.1016/J.Str.2005.07.001 |
0.455 |
|
2005 |
Wright GD. Bacterial resistance to antibiotics: Enzymatic degradation and modification Advanced Drug Delivery Reviews. 57: 1451-1470. PMID 15950313 DOI: 10.1016/J.Addr.2005.04.002 |
0.482 |
|
2005 |
Mukhtar TA, Koteva KP, Wright GD. Chimeric streptogramin-tyrocidine antibiotics that overcome streptogramin resistance Chemistry and Biology. 12: 229-235. PMID 15734650 DOI: 10.1016/J.Chembiol.2004.12.009 |
0.433 |
|
2005 |
Brown ED, Wright GD. New targets and screening approaches in antimicrobial drug discovery Chemical Reviews. 105: 759-774. PMID 15700964 DOI: 10.1021/Cr030116O |
0.323 |
|
2005 |
Mukhtar TA, Wright GD. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis Chemical Reviews. 105: 529-542. PMID 15700955 DOI: 10.1021/Cr030110Z |
0.403 |
|
2005 |
Walsh C, Wright G. Introduction: antibiotic resistance. Chemical Reviews. 105: 391-4. PMID 15700949 DOI: 10.1021/Cr030100Y |
0.626 |
|
2005 |
Lamb SS, Wright GD. Accessorizing natural products: Adding to nature's toolbox Proceedings of the National Academy of Sciences of the United States of America. 102: 519-520. PMID 15647344 DOI: 10.1073/Pnas.0408858102 |
0.315 |
|
2004 |
Li X, Zolli-Juran M, Cechetto JD, Daigle DM, Wright GD, Brown ED. Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility. Chemistry & Biology. 11: 1423-30. PMID 15489169 DOI: 10.1016/J.Chembiol.2004.08.014 |
0.758 |
|
2004 |
Yang W, Moore IF, Koteva KP, Bareich DC, Hughes DW, Wright GD. TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics. The Journal of Biological Chemistry. 279: 52346-52. PMID 15452119 DOI: 10.1074/Jbc.M409573200 |
0.832 |
|
2004 |
Boehr DD, Daigle DM, Wright GD. Domain-domain interactions in the aminoglycoside antibiotic resistance enzyme AAC(6')-APH(2''). Biochemistry. 43: 9846-55. PMID 15274639 DOI: 10.1021/Bi049135Y |
0.82 |
|
2004 |
Ejim L, Mirza IA, Capone C, Nazi I, Jenkins S, Chee GL, Berghuis AM, Wright GD. New phenolic inhibitors of yeast homoserine dehydrogenase. Bioorganic & Medicinal Chemistry. 12: 3825-30. PMID 15210149 DOI: 10.1016/J.Bmc.2004.05.009 |
0.418 |
|
2004 |
Ejim LJ, D'Costa VM, Elowe NH, Loredo-Osti JC, Malo D, Wright GD. Cystathionine β-lyase is important for virulence of Salmonella enterica serovar typhimurium Infection and Immunity. 72: 3310-3314. PMID 15155634 DOI: 10.1128/Iai.72.6.3310-3314.2004 |
0.387 |
|
2004 |
Hong HJ, Hutchings MI, Neu JM, Wright GD, Paget MS, Buttner MJ. Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance. Molecular Microbiology. 52: 1107-21. PMID 15130128 DOI: 10.1111/J.1365-2958.2004.04032.X |
0.448 |
|
2004 |
Bareich D, Koteva K, Nazi I, Wright GD. Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine Bioorganic and Medicinal Chemistry. 12: 807-815. PMID 14759741 DOI: 10.1016/J.Bmc.2003.10.042 |
0.789 |
|
2004 |
Draker KA, Wright GD. Molecular mechanism of the enterococcal aminoglycoside 6'-N-acetyltransferase': role of GNAT-conserved residues in the chemistry of antibiotic inactivation. Biochemistry. 43: 446-54. PMID 14717599 DOI: 10.1021/Bi035667N |
0.819 |
|
2004 |
Nazi I, Koteva KP, Wright GD. One-pot chemoenzymatic preparation of coenzyme A analogues Analytical Biochemistry. 324: 100-105. PMID 14654051 DOI: 10.1016/J.Ab.2003.09.005 |
0.384 |
|
2003 |
Bareich DC, Wright GD. Functionally important amino acids in Saccharomyces cerevisiae aspartate kinase. Biochemical and Biophysical Research Communications. 311: 597-603. PMID 14623312 DOI: 10.1016/J.Bbrc.2003.10.042 |
0.781 |
|
2003 |
Jacques SL, Mirza IA, Ejim L, Koteva K, Hughes DW, Green K, Kinach R, Honek JF, Lai HK, Berghuis AM, Wright GD. Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase. Chemistry & Biology. 10: 989-95. PMID 14583265 DOI: 10.1016/J.Chembiol.2003.09.015 |
0.756 |
|
2003 |
Bareich DC, Nazi I, Wright GD. Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor. Chemistry & Biology. 10: 967-73. PMID 14583263 DOI: 10.1016/J.Chembiol.2003.09.016 |
0.798 |
|
2003 |
Wright GD. Mechanisms of resistance to antibiotics Current Opinion in Chemical Biology. 7: 563-569. PMID 14580559 DOI: 10.1016/J.Cbpa.2003.08.004 |
0.479 |
|
2003 |
Draker KA, Northrop DB, Wright GD. Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6')-Ii from Enterococcus faecium: evidence of dimer subunit cooperativity. Biochemistry. 42: 6565-74. PMID 12767240 DOI: 10.1021/Bi034148H |
0.796 |
|
2003 |
Draker KA, Boehr DD, Elowe NH, Noga TJ, Wright GD. Functional annotation of putative aminoglycoside antibiotic modifying proteins in Mycobacterium tuberculosis H37Rv. The Journal of Antibiotics. 56: 135-42. PMID 12715873 DOI: 10.7164/Antibiotics.56.135 |
0.805 |
|
2003 |
Boehr DD, Draker KA, Koteva K, Bains M, Hancock RE, Wright GD. Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes. Chemistry & Biology. 10: 189-96. PMID 12618191 DOI: 10.1016/S1074-5521(03)00026-7 |
0.818 |
|
2003 |
Boehr DD, Jenkins SI, Wright GD. The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6'-aminoglycoside phosphotransferase-2". The role of ASP-99 as an active site base important for acetyl transfer. The Journal of Biological Chemistry. 278: 12873-80. PMID 12566434 DOI: 10.1074/Jbc.M211680200 |
0.754 |
|
2003 |
Wright GD. The “Molecular Logic” Underlying Antibiotic Activity and Structure Chemistry & Biology. 10: 381-382. DOI: 10.1016/S1074-5521(03)00105-4 |
0.432 |
|
2002 |
Boehr DD, Farley AR, Wright GD, Cox JR. Analysis of the pi-pi stacking interactions between the aminoglycoside antibiotic kinase APH(3')-IIIa and its nucleotide ligands. Chemistry & Biology. 9: 1209-17. PMID 12445771 DOI: 10.1016/S1074-5521(02)00245-4 |
0.675 |
|
2002 |
Johnston NJ, Mukhtar TA, Wright GD. Streptogramin antibiotics: Mode of action and resistance Current Drug Targets. 3: 335-344. PMID 12102603 DOI: 10.2174/1389450023347678 |
0.478 |
|
2002 |
Pootoolal J, Thomas MG, Marshall CG, Neu JM, Hubbard BK, Walsh CT, Wright GD. Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009. Proceedings of the National Academy of Sciences of the United States of America. 99: 8962-7. PMID 12060705 DOI: 10.1073/Pnas.102285099 |
0.698 |
|
2002 |
Thompson PR, Boehr DD, Berghuis AM, Wright GD. Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop. Biochemistry. 41: 7001-7. PMID 12033933 DOI: 10.1021/Bi0256680 |
0.755 |
|
2002 |
Neu JM, MacMillan SV, Nodwell JR, Wright GD. StoPK-1, a serine/threonine protein kinase from the glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009, affects oxidative stress response. Molecular Microbiology. 44: 417-30. PMID 11972780 DOI: 10.1046/J.1365-2958.2002.02879.X |
0.373 |
|
2002 |
Pootoolal J, Neu J, Wright GD. Glycopeptide antibiotic resistance Annual Review of Pharmacology and Toxicology. 42: 381-408. PMID 11807177 DOI: 10.1146/Annurev.Pharmtox.42.091601.142813 |
0.437 |
|
2001 |
Boehr DD, Lane WS, Wright GD. Active site labeling of the gentamicin resistance enzyme AAC(6')-APH(2") by the lipid kinase inhibitor wortmannin. Chemistry & Biology. 8: 791-800. PMID 11514228 DOI: 10.1016/S1074-5521(01)00051-5 |
0.738 |
|
2001 |
Mukhtar TA, Koteva KP, Hughes DW, Wright GD. Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis Biochemistry. 40: 8877-8886. PMID 11467949 DOI: 10.1021/Bi0106787 |
0.478 |
|
2001 |
Neu JM, Wright GD. Inhibition of sporulation, glycopeptide antibiotic production and resistance in Streptomyces toyocaensis NRRL 15009 by protein kinase inhibitors Fems Microbiology Letters. 199: 15-20. PMID 11356561 DOI: 10.1111/J.1574-6968.2001.Tb10644.X |
0.373 |
|
2001 |
Jacques SL, Ejim LJ, Wright GD. Homoserine dehydrogenase from Saccharomyces cerevisiae: Kinetic mechanism and stereochemistry of hydride transfer Biochimica Et Biophysica Acta - Protein Structure and Molecular Enzymology. 1544: 42-54. PMID 11341915 DOI: 10.1016/S0167-4838(00)00202-8 |
0.383 |
|
2001 |
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD. Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity. Biochimica Et Biophysica Acta. 1544: 28-41. PMID 11341914 DOI: 10.1016/S0167-4838(00)00203-X |
0.787 |
|
2001 |
Boehr DD, Thompson PR, Wright GD. Molecular mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: roles of conserved active site residues. The Journal of Biological Chemistry. 276: 23929-36. PMID 11279088 DOI: 10.1074/Jbc.M100540200 |
0.752 |
|
2000 |
Wright GD. Resisting resistance: New chemical strategies for battling superbugs Chemistry and Biology. 7. PMID 10873842 DOI: 10.1016/S1074-5521(00)00126-5 |
0.424 |
|
2000 |
DeLaBarre B, Thompson PR, Wright GD, Berghuis AM. Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases. Nature Structural Biology. 7: 238-44. PMID 10700284 DOI: 10.1038/73359 |
0.542 |
|
2000 |
Sucheck SJ, Wong AL, Koeller KM, Boehr DD, Draker KA, Sears P, Wright GD, Wong CH. Design of bifunctional antibiotics that target bacterial rRNA and inhibit resistance-causing enzymes [11] Journal of the American Chemical Society. 122: 5230-5231. DOI: 10.1021/Ja000575W |
0.813 |
|
1999 |
Thompson PR, Schwartzenhauer J, Hughes DW, Berghuis AM, Wright GD. The COOH terminus of aminoglycoside phosphotransferase (3')-IIIa is critical for antibiotic recognition and resistance Journal of Biological Chemistry. 274: 30697-30706. PMID 10521458 DOI: 10.1074/Jbc.274.43.30697 |
0.599 |
|
1999 |
Wright GD. Aminoglycoside-modifying enzymes Current Opinion in Microbiology. 2: 499-503. PMID 10508725 DOI: 10.1016/S1369-5274(99)00007-7 |
0.489 |
|
1999 |
Marshall CG, Zolli M, Wright GD. Molecular mechanism of VanHst, an α-ketoacid dehydrogenase required for glycopeptide antibiotic resistance from a glycopeptide producing organism Biochemistry. 38: 8485-8491. PMID 10387095 DOI: 10.1021/bi982843x |
0.37 |
|
1999 |
Wybenga-Groot LE, Draker Ka, Wright GD, Berghuis AM. Crystal structure of an aminoglycoside 6'-N-acetyltransferase: Defining the GCN5-related N-acetyltransferase superfamily fold Structure. 7: 497-507. PMID 10378269 DOI: 10.1016/S0969-2126(99)80066-5 |
0.815 |
|
1999 |
Daigle DM, Hughes DW, Wright GD. Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci. Chemistry & Biology. 6: 99-110. PMID 10021417 DOI: 10.1016/S1074-5521(99)80006-4 |
0.795 |
|
1999 |
Daigle DM, McKay GA, Thompson PR, Wright GD. Aminoglycoside antibiotic phosphotransferases are also serine protein kinases. Chemistry & Biology. 6: 11-8. PMID 9889150 DOI: 10.1016/S1074-5521(99)80016-7 |
0.802 |
|
1999 |
Wright GD, Thompson PR. Aminoglycoside phosphotransferases: proteins, structure, and mechanism Frontiers in Bioscience : a Journal and Virtual Library. 4. PMID 9872733 DOI: 10.2741/Wright |
0.647 |
|
1998 |
Marshall CG, Wright GD. DdlN from vancomycin-producing Amycolatopsis orientalis C329.2 is a VanA homologue with D-alanyl-D-lactate ligase activity Journal of Bacteriology. 180: 5792-5795. PMID 9791137 DOI: 10.1128/Jb.180.21.5792-5795.1998 |
0.428 |
|
1998 |
Romo D, Harrison PH, Jenkins SI, Riddoch RW, Park K, Yang HW, Zhao C, Wright GD. Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (beta-lactones). Bioorganic & Medicinal Chemistry. 6: 1255-72. PMID 9784867 DOI: 10.1016/S0968-0896(98)00114-X |
0.305 |
|
1998 |
Marshall CG, Lessard IAD, Park IS, Wright GD. Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms Antimicrobial Agents and Chemotherapy. 42: 2215-2220. PMID 9736537 DOI: 10.1128/Aac.42.9.2215 |
0.423 |
|
1998 |
Thompson PR, Hughes DW, Cianciotto NP, Wright GD. Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues. The Journal of Biological Chemistry. 273: 14788-95. PMID 9614079 DOI: 10.1074/Jbc.273.24.14788 |
0.626 |
|
1998 |
DiGiammarino EL, Draker KA, Wright GD, Serpersu EH. Solution studies of isepamicin and conformational comparisons between isepamicin and butirosin A when bound to an aminoglycoside 6'-N-acetyltransferase determined by NMR spectroscopy. Biochemistry. 37: 3638-44. PMID 9521682 DOI: 10.1021/Bi972778B |
0.787 |
|
1998 |
Marshall CG, Wright GD. DdlN from Vancomycin-Producing Amycolatopsis orientalis C329.2 Is a VanA Homologue withd-Alanyl-d-Lactate Ligase Activity Journal of Bacteriology. 180: 5792-5795. DOI: 10.1128/jb.180.21.5792-5795.1998 |
0.329 |
|
1998 |
Marshall CG, Lessard IAD, Park I, Wright GD. Glycopeptide Antibiotic Resistance Genes in Glycopeptide-Producing Organisms Antimicrobial Agents and Chemotherapy. 42: 2215-2220. DOI: 10.1128/aac.42.9.2215 |
0.308 |
|
1997 |
Marshall CG, Wright GD. The glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009 has both D-alanyl-D-alanine and D-alanyl-D-lactate ligases Fems Microbiology Letters. 157: 295-299. PMID 9435111 DOI: 10.1111/J.1574-6968.1997.Tb12788.X |
0.312 |
|
1997 |
Daigle DM, McKay GA, Wright GD. Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors. The Journal of Biological Chemistry. 272: 24755-8. PMID 9312069 DOI: 10.1074/Jbc.272.40.24755 |
0.785 |
|
1997 |
Davies J, Wright GD. Bacterial resistance to aminoglycoside antibiotics Trends in Microbiology. 5: 234-240. PMID 9211644 DOI: 10.1016/S0966-842X(97)01033-0 |
0.471 |
|
1997 |
Hon WC, McKay GA, Thompson PR, Sweet RM, Yang DSC, Wright GD, Berghuis AM. Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases Cell. 89: 887-895. PMID 9200607 DOI: 10.1016/S0092-8674(00)80274-3 |
0.622 |
|
1997 |
Marshall CG, Broadhead G, Leskiw BK, Wright GD. D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB Proceedings of the National Academy of Sciences of the United States of America. 94: 6480-6483. PMID 9177243 DOI: 10.1073/Pnas.94.12.6480 |
0.364 |
|
1997 |
Wright GD, Ladak P. Overexpression and characterization of the chromosomal aminoglycoside 6'-N-acetyltransferase from Enterococcus faecium Antimicrobial Agents and Chemotherapy. 41: 956-960. PMID 9145851 DOI: 10.1128/Aac.41.5.956 |
0.401 |
|
1997 |
Wright GD, Ladak P. Overexpression and characterization of the chromosomal aminoglycoside 6'-N-acetyltransferase from Enterococcus faecium. Antimicrobial Agents and Chemotherapy. 41: 956-960. DOI: 10.1128/aac.41.5.956 |
0.325 |
|
1996 |
Thompson PR, Hughes DW, Wright GD. Mechanism of aminoglycoside 3'-phosphotransferase type IIIa: His188 is not a phosphate-accepting residue Chemistry and Biology. 3: 747-755. PMID 8939691 DOI: 10.1016/S1074-5521(96)90251-3 |
0.58 |
|
1996 |
McKay GA, Roestamadji J, Mobashery S, Wright GD. Recognition of aminoglycoside antibiotics by enterococcal- staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: Role of substrate amino groups Antimicrobial Agents and Chemotherapy. 40: 2648-2650. PMID 8913482 DOI: 10.1128/Aac.40.11.2648 |
0.373 |
|
1996 |
Thompson PR, Hughes DW, Wright GD. Regiospecificity of aminoglycoside phosphotransferase from Enterococci and Staphylococci (APH(3')-IIIa) Biochemistry. 35: 8686-8695. PMID 8679631 DOI: 10.1021/Bi960389W |
0.637 |
|
1996 |
McKay GA, Wright GD. Catalytic mechanism of enterococcal kanamycin kinase (APH(3')-IIIa): Viscosity, thio, and solvent isotope effects support a Theorell-Chance mechanism Biochemistry. 35: 8680-8685. PMID 8679630 DOI: 10.1021/Bi9603884 |
0.415 |
|
1996 |
Marshall GC, Wright GD. Purification and characterization of two haloperoxidases from the glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009 Biochemical and Biophysical Research Communications. 219: 580-583. PMID 8605030 DOI: 10.1006/Bbrc.1996.0276 |
0.436 |
|
1996 |
Hon W-, Wright GD, Yang DS, Berghuis AM. Towards unravelling the structure of an antibiotics-inactivating enzyme – kanamycin kinase Acta Crystallographica Section a Foundations of Crystallography. 52: C204-C204. DOI: 10.1107/S0108767396091179 |
0.445 |
|
1996 |
Cox JR, McKay GA, Wright GD, Serpersu EH. Arrangement of Substrates at the Active Site of an Aminoglycoside Antibiotic 3‘-Phosphotransferase As Determined by NMR Journal of the American Chemical Society. 118: 1295-1301. DOI: 10.1021/Ja952994C |
0.478 |
|
1995 |
Wu Z, Wright GD, Walsh CT. Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147. Biochemistry. 34: 2455-63. PMID 7873524 DOI: 10.1021/Bi00008A008 |
0.549 |
|
1995 |
McKay GA, Wright GD. Kinetic mechanism of aminoglycoside phosphotransferase type IIIa: Evidence for a theorell-chance mechanism Journal of Biological Chemistry. 270: 24686-24692. PMID 7559583 DOI: 10.1074/Jbc.270.42.24686 |
0.408 |
|
1994 |
McKay GA, Thompson PR, Wright GD. Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: Overexpression, purification, and substrate specificity Biochemistry. 33: 6936-6944. PMID 8204627 DOI: 10.1021/Bi00188A024 |
0.569 |
|
1994 |
McKay GA, Robinson RA, Lane WS, Wright GD. Active-site labeling of an aminoglycoside Antibiotic Phosphotransferase (APH(3′)-IIIa) Biochemistry. 33: 14115-14120. PMID 7947822 DOI: 10.1021/Bi00251A021 |
0.439 |
|
1993 |
Wright GD, Holman TR, Walsh CT. Purification and characterization of VanR and the cytosolic domain of VanS: a two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4147. Biochemistry. 32: 5057-63. PMID 8494882 DOI: 10.1021/Bi00070A013 |
0.622 |
|
1993 |
Wright GD, Walsh CT. Identification of a common protease-sensitive region in D-alanyl-D-alanine and D-alanyl-D-lactate ligases and photoaffinity labeling with 8-azido ATP. Protein Science : a Publication of the Protein Society. 2: 1765-9. PMID 8251948 DOI: 10.1002/Pro.5560021020 |
0.511 |
|
1992 |
Wright GD, Molinas C, Arthur M, Courvalin P, Walsh CT. Characterization of vanY, a DD-carboxypeptidase from vancomycin-resistant Enterococcus faecium BM4147. Antimicrobial Agents and Chemotherapy. 36: 1514-8. PMID 1510448 DOI: 10.1128/Aac.36.7.1514 |
0.626 |
|
1992 |
Arthur M, Molinas C, Bugg TD, Wright GD, Walsh CT, Courvalin P. Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci. Antimicrobial Agents and Chemotherapy. 36: 867-9. PMID 1503450 DOI: 10.1128/Aac.36.4.867 |
0.591 |
|
1992 |
Wright GD, Walsh CT. D-Alanyl-D-alanine ligases and the molecular mechanism of vancomycin resistance Accounts of Chemical Research. 25: 468-473. DOI: 10.1021/Ar00022A006 |
0.566 |
|
1992 |
Wright GD, Honek JF. Synthesis and evaluation of photoaffinity probes directed at lanosterol 14α-demethylase (P-45014DM) Bioorganic and Medicinal Chemistry Letters. 2: 383-386. DOI: 10.1016/S0960-894X(00)80151-1 |
0.687 |
|
1991 |
Bugg TD, Wright GD, Dutka-Malen S, Arthur M, Courvalin P, Walsh CT. Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry. 30: 10408-15. PMID 1931965 DOI: 10.1021/Bi00107A007 |
0.589 |
|
1991 |
Wright GD, Honek JF. Induction and substrate specificity of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae Y222. Journal of Bacteriology. 173: 1035-40. PMID 1846852 DOI: 10.1128/Jb.173.3.1035-1040.1991 |
0.708 |
|
1990 |
Wright GD, Parent T, Honek JF. Non-sterol structural probes of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae. Biochimica Et Biophysica Acta. 1040: 95-101. PMID 2198946 DOI: 10.1016/0167-4838(90)90151-5 |
0.731 |
|
1989 |
Wright GD, Honek JF. Effects of iron binding agents on Saccharomyces cerevisiae growth and cytochrome P450 content. Canadian Journal of Microbiology. 35: 945-50. PMID 2531030 DOI: 10.1139/M89-156 |
0.692 |
|
1989 |
Goh CJ, Szczepan EW, Wright G, Menhart N, Honek JF, Viswanatha T. Investigation of lysine: N-hydroxylation in the biosynthesis of the siderophore aerobactin Bioorganic Chemistry. 17: 13-27. DOI: 10.1016/0045-2068(89)90003-5 |
0.731 |
|
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