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Aaron M. Ring, M.D./Ph.D. - Publications

Affiliations: 
2016- Yale University School of Medicine, New Haven, CT 
Area:
Immunology, protein engineering, pharmacology, cancer immunotherapy
Website:
https://medicine.yale.edu/immuno/programs/aaron_ring-2.profile
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53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Pierce CA, Preston-Hurlburt P, Dai Y, Aschner CB, Cheshenko N, Galen B, Garforth SJ, Herrera NG, Jangra RK, Morano NC, Orner E, Sy S, Chandran K, Dziura J, Almo SC, ... Ring A, et al. Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients. Science Translational Medicine. PMID 32958614 DOI: 10.1126/Scitranslmed.Abd5487  0.375
2020 Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, Lu P, Weizman OE, Liu F, Dai Y, Szigeti-Buck K, Yasumoto Y, Wang G, Castaldi C, Heltke J, ... ... Ring A, et al. Neuroinvasion of SARS-CoV-2 in human and mouse brain. Biorxiv : the Preprint Server For Biology. PMID 32935108 DOI: 10.1101/2020.06.25.169946  0.543
2020 Song E, Chow RD, Jiang R, Zamecnik CR, Loudermilk RP, Dai Y, Liu F, Geng B, Chiarella J, Israelow B, Casanovas-Massana A, Ko AI, Ring A, Kleinstein SH, Spudich S, et al. Immunologically distinct responses occur in the CNS of COVID-19 patients. Biorxiv : the Preprint Server For Biology. PMID 32935102 DOI: 10.1101/2020.09.11.293464  0.6
2020 Cao Y, Rosen C, Arora G, Gupta A, Booth CJ, Murfin KE, Cerny J, Marin Lopez A, Chuang YM, Tang X, Pal U, Ring A, Narasimhan S, Fikrig E. An protein disulfide isomerase contributes to colonization of the vector. Infection and Immunity. PMID 32928964 DOI: 10.1128/Iai.00426-20  0.753
2020 Takahashi T, Ellingson MK, Wong P, Israelow B, Lucas C, Klein J, Silva J, Mao T, Oh JE, Tokuyama M, Lu P, Venkataraman A, Park A, Liu F, Meir A, ... ... Ring AM, et al. Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature. PMID 32846427 DOI: 10.1038/S41586-020-2700-3  0.608
2020 Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. The Journal of Experimental Medicine. 217. PMID 32750141 DOI: 10.1084/Jem.20201241  0.597
2020 Goldman-Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer R, Ring A, Wilen C, Iwasaki A. Mouse Model of SARS-CoV-2 Reveals Inflammatory Role of Type I Interferon Signaling. Ssrn. 3628297. PMID 32714125 DOI: 10.2139/ssrn.3628297  0.566
2020 Zhou T, Damsky W, Weizman OE, McGeary MK, Hartmann KP, Rosen CE, Fischer S, Jackson R, Flavell RA, Wang J, Sanmamed MF, Bosenberg MW, Ring AM. IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy. Nature. PMID 32581358 DOI: 10.1038/S41586-020-2422-6  0.794
2020 Takahashi T, Wong P, Ellingson M, Lucas C, Klein J, Israelow B, Silva J, Oh J, Mao T, Tokuyama M, Lu P, Venkataraman A, Park A, Liu F, Meir A, ... ... Ring A, et al. Sex differences in immune responses to SARS-CoV-2 that underlie disease outcomes. Medrxiv : the Preprint Server For Health Sciences. PMID 32577695 DOI: 10.1101/2020.06.06.20123414  0.571
2020 Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. Biorxiv : the Preprint Server For Biology. PMID 32577647 DOI: 10.1101/2020.05.27.118893  0.573
2020 Hosier H, Farhadian SF, Morotti RA, Deshmukh U, Lu-Culligan A, Campbell KH, Yasumoto Y, Vogels CB, Casanovas-Massana A, Vijayakumar P, Geng B, Odio CD, Fournier J, Brito AF, Fauver JR, ... ... Ring AM, et al. SARS-CoV-2 infection of the placenta. The Journal of Clinical Investigation. PMID 32573498 DOI: 10.1172/Jci139569  0.547
2020 Jarret A, Jackson R, Duizer C, Healy ME, Zhao J, Rone JM, Bielecki P, Sefik E, Roulis M, Rice T, Sivanathan KN, Zhou T, Solis AG, Honcharova-Biletska H, Vélez K, ... ... Ring AM, et al. Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity. Cell. 180: 813-814. PMID 32084342 DOI: 10.1016/J.Cell.2020.02.004  0.437
2020 Jarret A, Jackson R, Duizer C, Healy ME, Zhao J, Rone JM, Bielecki P, Sefik E, Roulis M, Rice T, Sivanathan KN, Zhou T, Solis AG, Honcharova-Biletska H, Vélez K, ... ... Ring AM, et al. Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity. Cell. 180: 50-63.e12. PMID 31923399 DOI: 10.1016/J.Cell.2019.12.016  0.465
2020 Wang EY, Rosen CE, Dai Y, Sanmamed MF, Ring AM. Abstract 6292: Novel seroprofiling assay reveals previously undescribed autoantibody responses in immunotherapy treated cancer patients Cancer Research. 80: 6292-6292. DOI: 10.1158/1538-7445.Am2020-6292  0.799
2020 Weizman O, Zhou T, Damsky W, McGeary M, Bosenberg MW, Ring AM. Abstract 3424: IL-18 immunotherapy is efficacious against checkpoint-immunotherapy refractory tumors by promoting the maturation of highly proliferative, polyfunctional NK cells Cancer Research. 80: 3424-3424. DOI: 10.1158/1538-7445.Am2020-3424  0.535
2020 Zhou T, Weizman O, Damsky W, McGeary M, Bosenberg MW, Ring AM. Abstract 2156: IL-18 pathway agonism expands intratumoral PD1+ Tcf1+ stem-like CD8+ cells and their polyfunctional effector progeny to promote anti-tumor immunity Cancer Research. 80: 2156-2156. DOI: 10.1158/1538-7445.Am2020-2156  0.568
2019 Luan H, Wang A, Hilliard B, Carvalho F, Rosen C, Ahasic A, Herzog E, Kang I, Pisani M, Yu S, Zhang C, Ring A, Young L, Medzhitov R. GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance. Cell. PMID 31402172 DOI: 10.1016/J.Cell.2019.07.033  0.748
2019 Anderson KL, Snyder KM, Ito D, Lins DC, Mills LJ, Weiskopf K, Ring NG, Ring AM, Shimizu Y, Mescher MF, Weissman IL, Modiano JF. Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade. Melanoma Research. PMID 31205227 DOI: 10.1097/Cmr.0000000000000629  0.754
2019 Chen H, Nwe PK, Yang Y, Rosen CE, Bielecka AA, Kuchroo M, Cline GW, Kruse AC, Ring AM, Crawford JM, Palm NW. A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology. Cell. PMID 31006530 DOI: 10.1016/J.Cell.2019.03.036  0.754
2019 Anderson KL, Snyder KM, Ito D, Lins DC, Mills LJ, Weiskopf K, Ring NG, Ring AM, Shimizu Y, Mescher MF, Weissman IL, Modiano JF. Abstract A051: Melanoma displays an evolutionarily conserved resistance to upregulation of prophagocytic signals and to CD47 blockade Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A051  0.764
2018 McMahon C, Baier AS, Pascolutti R, Wegrecki M, Zheng S, Ong JX, Erlandson SC, Hilger D, Rasmussen SGF, Ring AM, Manglik A, Kruse AC. Yeast surface display platform for rapid discovery of conformationally selective nanobodies. Nature Structural & Molecular Biology. PMID 29434346 DOI: 10.1038/S41594-018-0028-6  0.325
2018 Barkal AA, Weiskopf K, Kao KS, Gordon SR, Rosental B, Yiu YY, George BM, Markovic M, Ring NG, Tsai JM, McKenna KM, Ho PY, Cheng RZ, Chen JY, Barkal LJ, ... Ring AM, et al. Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy. Nature Immunology. 19: 76-84. PMID 29180808 DOI: 10.1038/S41590-017-0004-Z  0.733
2017 Ring NG, Herndler-Brandstetter D, Weiskopf K, Shan L, Volkmer JP, George BM, Lietzenmayer M, McKenna KM, Naik TJ, McCarty A, Zheng Y, Ring AM, Flavell RA, Weissman IL. Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 29158380 DOI: 10.1073/Pnas.1710877114  0.826
2017 Pierini A, Iliopoulou BP, Peiris H, Pérez-Cruz M, Baker J, Hsu K, Gu X, Zheng PP, Erkers T, Tang SW, Strober W, Alvarez M, Ring A, Velardi A, Negrin RS, et al. T cells expressing chimeric antigen receptor promote immune tolerance. Jci Insight. 2. PMID 29046484 DOI: 10.1172/Jci.Insight.92865  0.386
2017 Gordon SR, Maute RL, Dulken BW, Hutter G, George BM, McCracken MN, Gupta R, Tsai JM, Sinha R, Corey D, Ring AM, Connolly AJ, Weissman IL. PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity. Nature. PMID 28514441 DOI: 10.1038/Nature22396  0.764
2017 Ho CC, Chhabra A, Starkl P, Schnorr PJ, Wilmes S, Moraga I, Kwon HS, Gaudenzio N, Sibilano R, Wehrman TS, Gakovic M, Sockolosky JT, Tiffany MR, Ring AM, Piehler J, et al. Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling. Cell. 168: 1041-1052.e18. PMID 28283060 DOI: 10.1016/J.Cell.2017.02.011  0.678
2016 Mayer AT, Natarajan A, Gordon S, Maute R, McCracken M, Ring A, Weissman I, Gambhir SS. Practical ImmunoPET radiotracer design considerations for human immune checkpoint imaging. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 27980047 DOI: 10.2967/Jnumed.116.177659  0.779
2016 Weiskopf K, Anderson KL, Ito D, Schnorr PJ, Tomiyasu H, Ring AM, Bloink K, Efe J, Rue S, Lowery D, Barkal A, Prohaska S, McKenna KM, Cornax I, O'Brien TD, et al. Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20. Cancer Immunology Research. PMID 27856424 DOI: 10.1158/2326-6066.Cir-16-0105  0.807
2016 Pascolutti R, Sun X, Kao J, Maute RL, Ring AM, Bowman GR, Kruse AC. Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant. Structure (London, England : 1993). PMID 27618663 DOI: 10.1016/J.Str.2016.06.026  0.722
2016 Chhabra A, Ring AM, Weiskopf K, Schnorr PJ, Gordon S, Le AC, Kwon HS, Ring NG, Volkmer J, Ho PY, Tseng S, Weissman IL, Shizuru JA. Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy. Science Translational Medicine. 8: 351ra105. PMID 27510901 DOI: 10.1126/Scitranslmed.Aae0501  0.778
2016 Weiskopf K, Jahchan NS, Schnorr PJ, Cristea S, Ring AM, Maute RL, Volkmer AK, Volkmer JP, Liu J, Lim JS, Yang D, Seitz G, Nguyen T, Wu D, Jude K, et al. CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. The Journal of Clinical Investigation. PMID 27294525 DOI: 10.1172/Jci81603  0.794
2016 Pierini A, Iliopoulou B, Peiris H, Perez Cruz M, Baker J, Hsu K, Strober W, Zheng P, Erkers T, Ring A, Velardi A, Negrin RS, Kim S, Meyer E. The Use of Monoclonal Antibody Directed Chimeric Antigen Receptors to Facilitate Conventional T Cell and Treg Control of GvHD and Tissue Tolerance in Murine Models Blood. 128: 3355-3355. DOI: 10.1182/Blood.V128.22.3355.3355  0.402
2016 Gordon SR, Maute R, Mayer A, McCracken M, Natarajan A, Guo N, Kimura R, Tsai JM, Manglik A, Kruse A, Gambhir S, Weissman IL, Ring AM. Abstract B101: Engineered PD-1 variants as immunotherapies for cancer Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-B101  0.796
2016 Corey D, Ring A, McCracken M, Miyanishi M, Gordon S, Weissman I. Abstract B051: Super cross-presentation of tumor antigens by synthetic design of an anti-phosphatidylserine bridge protein Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B051  0.802
2015 Maute RL, Gordon SR, Mayer AT, McCracken MN, Natarajan A, Ring NG, Kimura R, Tsai JM, Manglik A, Kruse AC, Gambhir SS, Weissman IL, Ring AM. Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging. Proceedings of the National Academy of Sciences of the United States of America. 112: E6506-14. PMID 26604307 DOI: 10.1073/Pnas.1519623112  0.777
2015 Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, et al. Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps. Immunity. 42: 826-38. PMID 25992859 DOI: 10.1016/J.Immuni.2015.04.018  0.768
2015 Spangler JB, Tomala J, Luca VC, Jude KM, Dong S, Ring AM, Votavova P, Pepper M, Kovar M, Garcia KC. Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity. 42: 815-25. PMID 25992858 DOI: 10.1016/J.Immuni.2015.04.015  0.705
2015 Ho CC, Guo N, Sockolosky JT, Ring AM, Weiskopf K, Özkan E, Mori Y, Weissman IL, Garcia KC. "Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein α (SIRPα) antagonists that enhance antibody-dependent cellular phagocytosis. The Journal of Biological Chemistry. 290: 12650-63. PMID 25837251 DOI: 10.1074/Jbc.M115.648220  0.81
2015 Weiskopf K, Ring A, Garcia KC, Weissman I. CD47-blocking therapies stimulate macrophage cytokine secretion and are effective in a model of peritoneal carcinomatosis Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-P248  0.791
2015 Chhabra A, Ring A, Weiskopf K, Schnorr PJ, Gordon S, Le AC, Kwon H, Guo N, Volkmer J, Ho PY, Tseng S, Weissman I, Shizuru J. HSC transplantation in an immunocompetent host without radiation or chemotherapy Experimental Hematology. 43: S57. DOI: 10.1016/J.Exphem.2015.06.101  0.74
2014 Ardolino M, Azimi CS, Iannello A, Trevino TN, Horan L, Zhang L, Deng W, Ring AM, Fischer S, Garcia KC, Raulet DH. Cytokine therapy reverses NK cell anergy in MHC-deficient tumors. The Journal of Clinical Investigation. 124: 4781-94. PMID 25329698 DOI: 10.1172/Jci74337  0.543
2014 Weiskopf K, Ring AM, Guo N, Schnorr PJ, Maute RL, Volkmer J, Weissman IL. Direct SIRPa Blockade Augments Macrophage Responses to Therapeutic Anticancer Antibodies Blood. 124: 2729-2729. DOI: 10.1182/Blood.V124.21.2729.2729  0.816
2014 Chhabra A, Ring AM, Weiskopf K, Weissman IL, Shizuru JA. Successful Engraftment of Hematopoietic Stem Cells into Immunocompetent Recipients Using Only Anti-CD117 Antibody and CD47 Blockade As Conditioning Blood. 124: 2410-2410. DOI: 10.1182/Blood.V124.21.2410.2410  0.782
2014 Weiskopf K, Schnorr PJ, Jahchan N, Ring AM, Maute RL, Volkmer AK, Volkmer J, Garcia KC, Sage J, Weissman IL. Abstract 3629: Overcoming macrophage immunosuppression in small cell lung cancer with high-affinity SIRPa variants Cancer Research. 74: 3629-3629. DOI: 10.1158/1538-7445.Am2014-3629  0.779
2013 Weiskopf K, Ring AM, Schnorr PJ, Volkmer JP, Volkmer AK, Weissman IL, Garcia KC. Improving macrophage responses to therapeutic antibodies by molecular engineering of SIRPα variants. Oncoimmunology. 2: e25773. PMID 24319639 DOI: 10.4161/Onci.25773  0.786
2013 Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, et al. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 504: 101-6. PMID 24256733 DOI: 10.1038/Nature12735  0.458
2013 Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK. Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody. Nature. 502: 575-9. PMID 24056936 DOI: 10.1038/Nature12572  0.458
2013 Weiskopf K, Ring AM, Ho CC, Volkmer JP, Levin AM, Volkmer AK, Ozkan E, Fernhoff NB, van de Rijn M, Weissman IL, Garcia KC. Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Science (New York, N.Y.). 341: 88-91. PMID 23722425 DOI: 10.1126/Science.1238856  0.826
2013 Sitrin J, Ring A, Garcia KC, Benoist C, Mathis D. Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2. The Journal of Experimental Medicine. 210: 1153-65. PMID 23650440 DOI: 10.1084/Jem.20122248  0.526
2013 Garcia KC, Ring A, Lin J, Levin A, Pande V, Bowman G, Craig K, Boyman O, Lin P. Probing the Relationship between Extracellular Ligand Recognition and Cytokine Receptor Activation with Structural Biology and Protein Engineering Biophysical Journal. 104: 45a. DOI: 10.1016/J.Bpj.2012.11.285  0.485
2012 Ring AM, Lin JX, Feng D, Mitra S, Rickert M, Bowman GR, Pande VS, Li P, Moraga I, Spolski R, Ozkan E, Leonard WJ, Garcia KC. Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nature Immunology. 13: 1187-95. PMID 23104097 DOI: 10.1038/Ni.2449  0.696
2012 Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC. Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature. 484: 529-33. PMID 22446627 DOI: 10.1038/Nature10975  0.501
2012 Willingham SB, Volkmer JP, Weiskopf K, Ring AM, Weissman IL. Reply to Soto-Pantoja et al. and Zhao et al.: Targeting CD47 on human solid tumors Proceedings of the National Academy of Sciences of the United States of America. 109: E2844-E2845. DOI: 10.1073/Pnas.1209743109  0.739
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