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Christopher N. LaRock, Ph.D. - Publications

Affiliations: 
Microbiology & Immunology Emory University, Atlanta, GA 
 2012 Microbiology University of Washington, Seattle, Seattle, WA 
 2017 Pediatrics University of California, San Diego, La Jolla, CA 
Area:
Microbiology Biology, Immunology, Biochemistry
Website:
larocklab.com
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Do H, Li ZR, Tripathi PK, Mitra S, Guerra S, Dash A, Weerasekera D, Makthal N, Shams S, Aggarwal S, Singh BB, Gu D, Du Y, Olsen RJ, LaRock C, et al. Engineered probiotic overcomes pathogen defences using signal interference and antibiotic production to treat infection in mice. Nature Microbiology. PMID 38228859 DOI: 10.1038/s41564-023-01583-9  0.317
2024 Guerra S, LaRock C. Group A Streptococcus interactions with the host across time and space. Current Opinion in Microbiology. 77: 102420. PMID 38219421 DOI: 10.1016/j.mib.2023.102420  0.369
2023 Wilde S, Dash A, Johnson A, Mackey K, Okumura CYM, LaRock CN. Detoxification of reactive oxygen species by the hyaluronic acid capsule of group A . Infection and Immunity. 91: e0025823. PMID 37874162 DOI: 10.1128/iai.00258-23  0.804
2023 LaRock DL, LaRock CN. Assessing Interleukin-1β Activation During Pyroptosis. Methods in Molecular Biology (Clifton, N.J.). 2641: 163-169. PMID 37074649 DOI: 10.1007/978-1-0716-3040-2_13  0.805
2023 Johnson AF, Sands JS, Trivedi KM, Russell R, LaRock DL, LaRock CN. Constitutive secretion of pro-IL-18 allows keratinocytes to initiate inflammation during bacterial infection. Plos Pathogens. 19: e1011321. PMID 37068092 DOI: 10.1371/journal.ppat.1011321  0.823
2023 Everett MJ, Davies DT, Leiris S, Sprynski N, Llanos A, Castandet JM, Lozano C, LaRock CN, LaRock DL, Corsica G, Docquier JD, Pallin TD, Cridland A, Blench T, Zalacain M, et al. Chemical Optimization of Selective LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models. Acs Infectious Diseases. PMID 36669138 DOI: 10.1021/acsinfecdis.2c00418  0.808
2022 LaRock DL, Johnson AF, Wilde S, Sands JS, Monteiro MP, LaRock CN. Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes. Nature. 605: 527-531. PMID 35545676 DOI: 10.1038/s41586-022-04717-x  0.794
2021 Johnson AF, LaRock CN. Antibiotic Treatment, Mechanisms for Failure, and Adjunctive Therapies for Infections by Group A . Frontiers in Microbiology. 12: 760255. PMID 34803985 DOI: 10.3389/fmicb.2021.760255  0.382
2021 Wilde S, Johnson AF, LaRock CN. Playing With Fire: Proinflammatory Virulence Mechanisms of Group A . Frontiers in Cellular and Infection Microbiology. 11: 704099. PMID 34295841 DOI: 10.3389/fcimb.2021.704099  0.333
2021 Atashgah RB, Ghasemi A, Raoufi M, Abdollahifar MA, Zanganeh S, Nejadnik H, Abdollahi A, Sharifi S, Lea B, Cuerva M, Akbarzadeh M, Alvarez-Lorenzo C, Ostad SN, Theus AS, LaRock DL, ... LaRock CN, et al. Restoring Endogenous Repair Mechanisms to Heal Chronic Wounds with a Multifunctional Wound Dressing. Molecular Pharmaceutics. PMID 34279974 DOI: 10.1021/acs.molpharmaceut.1c00400  0.727
2020 Sun J, LaRock DL, Skowronski EA, Kimmey JM, Olson J, Jiang Z, O'Donoghue AJ, Nizet V, LaRock CN. The Pseudomonas aeruginosa protease LasB directly activates IL-1β. Ebiomedicine. 60: 102984. PMID 32979835 DOI: 10.1016/j.ebiom.2020.102984  0.74
2020 Wilde S, Olivares KL, Nizet V, Hoffman HM, Radhakrishna S, LaRock CN. Opportunistic Invasive Infection by Group A Streptococcus During Anti-Interleukin-6 Immunotherapy. The Journal of Infectious Diseases. PMID 32808035 DOI: 10.1093/Infdis/Jiaa511  0.629
2020 LaRock DL, Russell R, Johnson AF, Wilde S, LaRock CN. Group A Streptococcus Infection of the Nasopharynx Requires Proinflammatory Signaling Through the Interleukin-1 Receptor. Infection and Immunity. PMID 32719155 DOI: 10.1128/Iai.00356-20  0.839
2019 Wierzbicki IH, Campeau A, Dehaini D, Holay M, Wei X, Greene T, Ying M, Sands JS, Lamsa A, Zuniga E, Pogliano K, Fang RH, LaRock CN, Zhang L, Gonzalez DJ. Group A Streptococcal S Protein Utilizes Red Blood Cells as Immune Camouflage and Is a Critical Determinant for Immune Evasion. Cell Reports. 29: 2979-2989.e15. PMID 31801066 DOI: 10.1016/J.Celrep.2019.11.001  0.532
2019 LaRock DL, Sands JS, Ettouati E, Richard M, Bushway PJ, Adler ED, Nizet V, LaRock CN. Inflammasome inhibition blocks cardiac glycoside cell toxicity. The Journal of Biological Chemistry. PMID 31300552 DOI: 10.1074/Jbc.Ra119.008330  0.78
2019 Dan JM, Havenar-Daughton C, Kendric K, Al-Kolla R, Kaushik K, Rosales SL, Anderson EL, LaRock CN, Vijayanand P, Seumois G, Layfield D, Cutress RI, Ottensmeier CH, Lindestam Arlehamn CS, Sette A, et al. Recurrent group A tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant T cells. Science Translational Medicine. 11. PMID 30728285 DOI: 10.1126/Scitranslmed.Aau3776  0.75
2017 Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, Zanotto PMA, Beltrão-Braga PCB, Nizet V, Muotri AR. Modeling neuro-immune interactions during Zika virus infection. Human Molecular Genetics. PMID 29048558 DOI: 10.1093/Hmg/Ddx382  0.529
2017 Valderrama JA, Riestra AM, Gao NJ, LaRock CN, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V. Group A streptococcal M protein activates the NLRP3 inflammasome. Nature Microbiology. PMID 28784982 DOI: 10.1038/S41564-017-0005-6  0.768
2017 Döhrmann S, LaRock CN, Anderson EL, Cole JN, Ryali B, Stewart C, Nonejuie P, Pogliano J, Corriden R, Ghosh P, Nizet V. Group A Streptococcal M1 Protein Provides Resistance against the Antimicrobial Activity of Histones. Scientific Reports. 7: 43039. PMID 28220899 DOI: 10.1038/Srep43039  0.722
2016 LaRock CN, Todd J, LaRock DL, Olson J, O'Donoghue AJ, Robertson AAB, Cooper MA, Hoffman HM, Nizet V. IL-1β is an innate immune sensor of microbial proteolysis. Science Immunology. 1: eaah3539. PMID 28783696 DOI: 10.1126/sciimmunol.aah3539  0.827
2016 LaRock CN, Todd J, LaRock DL, Olson J, O'Donoghue AJ, Robertson AA, Cooper MA, Hoffman HM, Nizet V. IL-1β is an innate immune sensor of microbial proteolysis. Science Immunology. 1. PMID 28331908 DOI: 10.1126/Sciimmunol.Aah3539  0.825
2015 LaRock CN, Nizet V. Inflammasome/IL-1β Responses to Streptococcal Pathogens. Frontiers in Immunology. 6: 518. PMID 26500655 DOI: 10.3389/Fimmu.2015.00518  0.682
2015 LaRock CN, Döhrmann S, Todd J, Corriden R, Olson J, Johannssen T, Lepenies B, Gallo RL, Ghosh P, Nizet V. Group A Streptococcal M1 Protein Sequesters Cathelicidin to Evade Innate Immune Killing. Cell Host & Microbe. 18: 471-7. PMID 26468750 DOI: 10.1016/J.Chom.2015.09.004  0.783
2015 LaRock CN, Nizet V. Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens. Biochimica Et Biophysica Acta. 1848: 3047-54. PMID 25701232 DOI: 10.1016/J.Bbamem.2015.02.010  0.535
2013 LaRock CN, Cookson BT. Burning down the house: cellular actions during pyroptosis. Plos Pathogens. 9: e1003793. PMID 24367258 DOI: 10.1371/Journal.Ppat.1003793  0.725
2013 Barnett TC, Liebl D, Seymour LM, Gillen CM, Lim JY, Larock CN, Davies MR, Schulz BL, Nizet V, Teasdale RD, Walker MJ. The globally disseminated M1T1 clone of group A Streptococcus evades autophagy for intracellular replication. Cell Host & Microbe. 14: 675-82. PMID 24331465 DOI: 10.1016/J.Chom.2013.11.003  0.586
2012 LaRock CN, Cookson BT. The Yersinia virulence effector YopM binds caspase-1 to arrest inflammasome assembly and processing. Cell Host & Microbe. 12: 799-805. PMID 23245324 DOI: 10.1016/J.Chom.2012.10.020  0.621
2009 Livny J, Larock CN, Friedman DI. Identification and isolation of lysogens with induced prophage. Methods in Molecular Biology (Clifton, N.J.). 501: 253-65. PMID 19066826 DOI: 10.1007/978-1-60327-164-6_22  0.318
2007 Held KG, LaRock CN, D'Argenio DA, Berg CA, Collins CM. A metalloprotease secreted by the insect pathogen Photorhabdus luminescens induces melanization. Applied and Environmental Microbiology. 73: 7622-8. PMID 17933944 DOI: 10.1128/Aem.01000-07  0.724
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